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Aliases for DCP1A Gene

Aliases for DCP1A Gene

  • Decapping MRNA 1A 2 3 5
  • Smad4-Interacting Transcriptional Co-Activator 3 4
  • Transcription Factor SMIF 3 4
  • SMIF 3 4
  • DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) 2
  • Putative Protein Product Of Nbla00360 3
  • DCP1 Decapping Enzyme-Like Protein A 3
  • DCP1 Decapping Enzyme Homolog A 3
  • MRNA-Decapping Enzyme 1A 3
  • Decapping Enzyme HDcp1a 3
  • EC 3.-.-.- 4
  • HSA275986 3
  • Nbla00360 3
  • SMAD4IP1 3

External Ids for DCP1A Gene

Previous GeneCards Identifiers for DCP1A Gene

  • GC03M053297
  • GC03M053319
  • GC03M053285
  • GC03M053288
  • GC03M053289
  • GC03M053290
  • GC03M053291

Summaries for DCP1A Gene

Entrez Gene Summary for DCP1A Gene

  • Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for DCP1A Gene

DCP1A (Decapping MRNA 1A) is a Protein Coding gene. Among its related pathways are Deadenylation-dependent mRNA decay and Gene Expression. GO annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is DCP1B.

UniProtKB/Swiss-Prot for DCP1A Gene

  • Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Gene Wiki entry for DCP1A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCP1A Gene

Genomics for DCP1A Gene

Regulatory Elements for DCP1A Gene

Enhancers for DCP1A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G053345 1.5 FANTOM5 ENCODE 11.2 +0.3 302 2.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC ENSG00000271976 DCP1A ENSG00000212608 PRKCD NT5DC2 TKT TMEM110 ENSG00000207109
GH03G053233 2 FANTOM5 Ensembl ENCODE dbSUPER 7 +108.2 108233 10.9 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 PRKCD ENSG00000207109 TKT DCP1A ITIH4 GNL3 TMEM110
GH03G053354 1.2 Ensembl ENCODE 10 -7.7 -7689 1.1 ATF1 ZNF133 TCF12 ZNF766 ELK1 GATA2 FOS KLF13 CAVIN1 ZNF592 ENSG00000207109 ENSG00000212608 DCP1A TKT LOC105377094
GH03G053140 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.2 +206.5 206526 1.4 HDGF ZSCAN4 ZNF133 ZNF143 ZNF207 EGR2 ZNF263 USF2 ZNF398 ZNF148 RFT1 PRKCD ACTR8 NEK4 TMEM110 ITIH4 DCP1A ITIH3 PBRM1 TKT
GH03G052890 1.5 FANTOM5 Ensembl ENCODE 5.2 +455.0 455003 4.3 HDGF ATF1 FOXA2 MLX ARID4B DMAP1 YY1 ZNF207 FOS MXD4 ITIH4 ENSG00000243696 ITIH4-AS1 PBRM1 MUSTN1 SNORD69 SNORD19 SNORD19B ENSG00000252787 ENSG00000222345
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCP1A on UCSC Golden Path with GeneCards custom track

Promoters for DCP1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152668 427 2401 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF416 ZNF143 SP3 NFYC

Genomic Location for DCP1A Gene

Chromosome:
3
Start:
53,283,423 bp from pter
End:
53,347,627 bp from pter
Size:
64,205 bases
Orientation:
Minus strand

Genomic View for DCP1A Gene

Genes around DCP1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCP1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP1A Gene

Proteins for DCP1A Gene

  • Protein details for DCP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI6-DCP1A_HUMAN
    Recommended name:
    mRNA-decapping enzyme 1A
    Protein Accession:
    Q9NPI6
    Secondary Accessions:
    • B4DHN9
    • U3KQM8

    Protein attributes for DCP1A Gene

    Size:
    582 amino acids
    Molecular mass:
    63309 Da
    Quaternary structure:
    • Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3 (PubMed:16364915). Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1 (PubMed:12515382). Interacts with DCP1B (PubMed:12417715). Interacts with DCP2 (PubMed:12417715). Interacts with DDX17 in an RNA-independent manner (PubMed:21876179). Interacts with PNRC2 (PubMed:19150429). Interacts with SMAD4 (PubMed:11836524). Interacts with UPF1 (PubMed:12417715). Interacts with ZC3HAV1 (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258). Interacts with NBDY (PubMed:27918561).

    Three dimensional structures from OCA and Proteopedia for DCP1A Gene

    Alternative splice isoforms for DCP1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP1A Gene

Post-translational modifications for DCP1A Gene

  • Ubiquitination at Lys17
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCP1A Gene

Domains & Families for DCP1A Gene

Protein Domains for DCP1A Gene

Suggested Antigen Peptide Sequences for DCP1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPI6

UniProtKB/Swiss-Prot:

DCP1A_HUMAN :
  • Belongs to the DCP1 family.
Family:
  • Belongs to the DCP1 family.
genes like me logo Genes that share domains with DCP1A: view

No data available for Gene Families for DCP1A Gene

Function for DCP1A Gene

Molecular function for DCP1A Gene

UniProtKB/Swiss-Prot Function:
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Enzyme Numbers (IUBMB) for DCP1A Gene

Gene Ontology (GO) - Molecular Function for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003729 mRNA binding IBA --
GO:0005515 protein binding IPI 12417715
GO:0008047 enzyme activator activity IEA --
GO:0016787 hydrolase activity IEA --
GO:0019894 kinesin binding IEA --
genes like me logo Genes that share ontologies with DCP1A: view
genes like me logo Genes that share phenotypes with DCP1A: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCP1A

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCP1A Gene

Localization for DCP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP1A Gene

Cytoplasm, P-body. Nucleus. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524). {ECO:0000250 UniProtKB:Q91YD3, ECO:0000269 PubMed:11836524, ECO:0000269 PubMed:16364915}.

Gene Ontology (GO) - Cellular Components for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body ISS,IDA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 24965446
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DCP1A: view

No data available for Subcellular locations from COMPARTMENTS for DCP1A Gene

Pathways & Interactions for DCP1A Gene

genes like me logo Genes that share pathways with DCP1A: view

Gene Ontology (GO) - Biological Process for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IBA,IEA --
GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA IBA --
GO:0043085 positive regulation of catalytic activity IEA --
GO:0043488 regulation of mRNA stability TAS --
genes like me logo Genes that share ontologies with DCP1A: view

No data available for SIGNOR curated interactions for DCP1A Gene

Drugs & Compounds for DCP1A Gene

No Compound Related Data Available

Transcripts for DCP1A Gene

Unigene Clusters for DCP1A Gene

DCP1 decapping enzyme homolog A (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCP1A

Alternative Splicing Database (ASD) splice patterns (SP) for DCP1A Gene

No ASD Table

Relevant External Links for DCP1A Gene

GeneLoc Exon Structure for
DCP1A
ECgene alternative splicing isoforms for
DCP1A

Expression for DCP1A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCP1A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.9), CD8 Tcells (10.3), Lymph node (7.9), and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCP1A Gene



Protein tissue co-expression partners for DCP1A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCP1A Gene:

DCP1A

SOURCE GeneReport for Unigene cluster for DCP1A Gene:

Hs.476353

mRNA Expression by UniProt/SwissProt for DCP1A Gene:

Q9NPI6-DCP1A_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
genes like me logo Genes that share expression patterns with DCP1A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCP1A Gene

Orthologs for DCP1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCP1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCP1A 34
  • 99.66 (n)
dog
(Canis familiaris)
Mammalia DCP1A 34
  • 90.17 (n)
cow
(Bos Taurus)
Mammalia DCP1A 34
  • 90.16 (n)
mouse
(Mus musculus)
Mammalia Dcp1a 34 16
  • 88.41 (n)
rat
(Rattus norvegicus)
Mammalia Dcp1a 34
  • 87.64 (n)
chicken
(Gallus gallus)
Aves DCP1A 34
  • 68.07 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp1a 34
  • 57.96 (n)
Str.19526 34
zebrafish
(Danio rerio)
Actinopterygii dcp1a 34
  • 61.44 (n)
mitc1 34
Species where no ortholog for DCP1A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCP1A Gene

ENSEMBL:
Gene Tree for DCP1A (if available)
TreeFam:
Gene Tree for DCP1A (if available)

Paralogs for DCP1A Gene

Paralogs for DCP1A Gene

(1) SIMAP similar genes for DCP1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCP1A: view

Variants for DCP1A Gene

Sequence variations from dbSNP and Humsavar for DCP1A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000001319 -- 53,296,170(+) GATTA(C/T)AGGCA intron-variant
rs1000168137 -- 53,331,366(+) GTGAC(A/T)GACTG intron-variant
rs1000266445 -- 53,317,139(+) CAACA(A/G)CCCTG intron-variant
rs1000379307 -- 53,323,195(+) CAGAA(G/T)CAAAC intron-variant, nc-transcript-variant
rs1000385577 -- 53,322,997(+) CTTTT(C/T)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCP1A Gene

Variant ID Type Subtype PubMed ID
nsv3825 CNV insertion 18451855
nsv517233 CNV loss 19592680
nsv834699 CNV loss 17160897

Variation tolerance for DCP1A Gene

Gene Damage Index Score: 2.77; 47.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCP1A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCP1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP1A Gene

Disorders for DCP1A Gene

Relevant External Links for DCP1A

Genetic Association Database (GAD)
DCP1A
Human Genome Epidemiology (HuGE) Navigator
DCP1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCP1A

No disorders were found for DCP1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCP1A Gene

Publications for DCP1A Gene

  1. Zinc-finger antiviral protein inhibits HIV-1 infection by selectively targeting multiply spliced viral mRNAs for degradation. (PMID: 21876179) Zhu Y. … Gao G. (Proc. Natl. Acad. Sci. U.S.A. 2011) 3 4 64
  2. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PMID: 19150429) Cho H. … Kim Y.K. (Mol. Cell 2009) 3 4 64
  3. New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. (PMID: 18513389) Penco S. … Grossi E. (BMC Bioinformatics 2008) 3 46 64
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  5. Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. (PMID: 15687258) Lykke-Andersen J. … Wagner E. (Genes Dev. 2005) 3 4 64

Products for DCP1A Gene

  • Addgene plasmids for DCP1A

Sources for DCP1A Gene

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