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Aliases for DCP1A Gene

Aliases for DCP1A Gene

  • Decapping MRNA 1A 2 3
  • SMIF 3 4 6
  • Smad4-Interacting Transcriptional Co-Activator 3 4
  • Transcription Factor SMIF 3 4
  • DCP1 Decapping Enzyme Homolog A (S. Cerevisiae) 2
  • Putative Protein Product Of Nbla00360 3
  • DCP1 Decapping Enzyme Homolog A 3
  • MRNA-Decapping Enzyme 1A 3
  • Decapping Enzyme HDcp1a 3
  • EC 3.-.-.- 4
  • HSA275986 3
  • Nbla00360 3
  • SMAD4IP1 3

External Ids for DCP1A Gene

Previous GeneCards Identifiers for DCP1A Gene

  • GC03M053297
  • GC03M053319

Summaries for DCP1A Gene

Entrez Gene Summary for DCP1A Gene

  • Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for DCP1A Gene

DCP1A (Decapping MRNA 1A) is a Protein Coding gene. Among its related pathways are Gene Expression and Regulation of nuclear SMAD2/3 signaling. GO annotations related to this gene include identical protein binding and hydrolase activity.

UniProtKB/Swiss-Prot for DCP1A Gene

  • Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Gene Wiki entry for DCP1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCP1A Gene

Genomics for DCP1A Gene

Regulatory Elements for DCP1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCP1A Gene

Start:
53,283,423 bp from pter
End:
53,347,627 bp from pter
Size:
64,205 bases
Orientation:
Minus strand

Genomic View for DCP1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCP1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCP1A Gene

Proteins for DCP1A Gene

  • Protein details for DCP1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPI6-DCP1A_HUMAN
    Recommended name:
    mRNA-decapping enzyme 1A
    Protein Accession:
    Q9NPI6
    Secondary Accessions:
    • B4DHN9
    • U3KQM8

    Protein attributes for DCP1A Gene

    Size:
    582 amino acids
    Molecular mass:
    63309 Da
    Quaternary structure:
    • Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 and LSM1. Interacts with PNRC2. Interacts with DDX17 in an RNA-independent manner. Interacts with ZC3HAV1.

    Three dimensional structures from OCA and Proteopedia for DCP1A Gene

    Alternative splice isoforms for DCP1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCP1A Gene

Proteomics data for DCP1A Gene at MOPED

Post-translational modifications for DCP1A Gene

  • Ubiquitination at Lys17
  • Modification sites at PhosphoSitePlus

Other Protein References for DCP1A Gene

No data available for DME Specific Peptides for DCP1A Gene

Domains for DCP1A Gene

Protein Domains for DCP1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCP1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NPI6

UniProtKB/Swiss-Prot:

DCP1A_HUMAN :
  • Q9NPI6
Family:
  • Belongs to the DCP1 family.
genes like me logo Genes that share domains with DCP1A: view

No data available for Gene Families for DCP1A Gene

Function for DCP1A Gene

Molecular function for DCP1A Gene

UniProtKB/Swiss-Prot Function: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.

Enzyme Numbers (IUBMB) for DCP1A Gene

Gene Ontology (GO) - Molecular Function for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12417715
GO:0016787 hydrolase activity IEA --
GO:0042802 identical protein binding IPI 16364915
genes like me logo Genes that share ontologies with DCP1A: view

Animal Model Products

CRISPR Products

miRNA for DCP1A Gene

miRTarBase miRNAs that target DCP1A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCP1A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCP1A Gene

Localization for DCP1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCP1A Gene

Cytoplasm, P-body. Nucleus. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCP1A Gene COMPARTMENTS Subcellular localization image for DCP1A gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DCP1A: view

Pathways for DCP1A Gene

genes like me logo Genes that share pathways with DCP1A: view

Gene Ontology (GO) - Biological Process for DCP1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA --
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0010467 gene expression TAS --
GO:0016070 RNA metabolic process --
GO:0016071 mRNA metabolic process --
genes like me logo Genes that share ontologies with DCP1A: view

Transcripts for DCP1A Gene

Unigene Clusters for DCP1A Gene

DCP1 decapping enzyme homolog A (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCP1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCP1A Gene

No ASD Table

Relevant External Links for DCP1A Gene

GeneLoc Exon Structure for
DCP1A
ECgene alternative splicing isoforms for
DCP1A

Expression for DCP1A Gene

mRNA expression in normal human tissues for DCP1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DCP1A Gene

SOURCE GeneReport for Unigene cluster for DCP1A Gene Hs.476353

mRNA Expression by UniProt/SwissProt for DCP1A Gene

Q9NPI6-DCP1A_HUMAN
Tissue specificity: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
genes like me logo Genes that share expressions with DCP1A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DCP1A Gene

Orthologs for DCP1A Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCP1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCP1A 35
  • 99.66 (n)
  • 99.66 (a)
cow
(Bos Taurus)
Mammalia DCP1A 35
  • 90.16 (n)
  • 89.98 (a)
dog
(Canis familiaris)
Mammalia DCP1A 35
  • 90.17 (n)
  • 90.69 (a)
mouse
(Mus musculus)
Mammalia Dcp1a 35
  • 88.41 (n)
  • 89.5 (a)
Dcp1a 16
rat
(Rattus norvegicus)
Mammalia Dcp1a 35
  • 87.64 (n)
  • 87.93 (a)
chicken
(Gallus gallus)
Aves DCP1A 35
  • 68.07 (n)
  • 61.23 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcp1a 35
  • 57.96 (n)
  • 52.44 (a)
Str.19526 35
zebrafish
(Danio rerio)
Actinopterygii dcp1a 35
  • 61.44 (n)
  • 56.31 (a)
mitc1 35
Species with no ortholog for DCP1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCP1A Gene

ENSEMBL:
Gene Tree for DCP1A (if available)
TreeFam:
Gene Tree for DCP1A (if available)

Paralogs for DCP1A Gene

Selected SIMAP similar genes for DCP1A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCP1A: view

No data available for Paralogs for DCP1A Gene

Variants for DCP1A Gene

Sequence variations from dbSNP and Humsavar for DCP1A Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs687346 -- 53,339,290(-) ATTTC(A/G)TTAGG intron-variant
rs922958 -- 53,326,523(+) AGCAG(A/G)AGGTG intron-variant
rs1001222 -- 53,318,072(+) GCCAA(A/G)GTGGG intron-variant
rs1038395 -- 53,340,660(-) TAATT(A/G)GCATC intron-variant
rs1552207 -- 53,305,952(-) AATTC(A/G)TAACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCP1A Gene

Variant ID Type Subtype PubMed ID
nsv834699 CNV Loss 17160897
nsv517233 CNV Loss 19592680
nsv3825 CNV Insertion 18451855
dgv5139n71 CNV Gain 21882294

Relevant External Links for DCP1A Gene

HapMap Linkage Disequilibrium report
DCP1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCP1A Gene

Disorders for DCP1A Gene

Relevant External Links for DCP1A

Genetic Association Database (GAD)
DCP1A
Human Genome Epidemiology (HuGE) Navigator
DCP1A
genes like me logo Genes that share disorders with DCP1A: view

No data available for UniProtKB/Swiss-Prot for DCP1A Gene

Publications for DCP1A Gene

  1. New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. (PMID: 18513389) Penco S. … Grossi E. (BMC Bioinformatics 2008) 3 48
  2. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PMID: 19150429) Cho H. … Kim Y.K. (Mol. Cell 2009) 3 4
  3. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. (PMID: 11836524) Bai R.-Y. … Duyster J. (Nat. Cell Biol. 2002) 3 4
  4. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PMID: 12417715) Lykke-Andersen J. (Mol. Cell. Biol. 2002) 3 4
  5. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PMID: 12515382) Ingelfinger D. … Achsel T. (RNA 2002) 3 4

Products for DCP1A Gene

  • Addgene plasmids for DCP1A

Sources for DCP1A Gene

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