Aliases for DCP1A Gene
External Ids for DCP1A Gene
Previous GeneCards Identifiers for DCP1A Gene
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
GeneCards Summary for DCP1A Gene
DCP1A (Decapping MRNA 1A) is a Protein Coding gene. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Regulation of nuclear SMAD2/3 signaling. GO annotations related to this gene include identical protein binding and hydrolase activity. An important paralog of this gene is DCP1B.
UniProtKB/Swiss-Prot for DCP1A Gene
Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.