DCP1A Gene
protein-coding GIFtS: 52
GCID: GC03M053319
|
|
DCP1 decapping enzyme homolog A (S. cerevisiae)
| |
Aliases for DCP1A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| DCP1 Decapping Enzyme Homolog A (S. Cerevisiae)1 2 | | Nbla003602 | | SMIF1 2 3 5 | | Decapping Enzyme HDcp1a2 | | HSA2759861 2 | | MRNA-Decapping Enzyme 1A2 | | SMAD4IP11 2 | | Putative Protein Product Of Nbla003602 | | Transcription Factor SMIF2 3 | | EC 3.-.-.-3 | | Smad4-Interacting Transcriptional Co-Activator2 3 | | |
Export aliases for DCP1A gene to outside databasesPrevious GC identifer: GC03M053297 |
Summaries for DCP1A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for DCP1A: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme.This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decayfactor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates inthe TGF-beta signaling pathway. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6Function: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay.Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP.Contributes to the transactivation of target genes after stimulation by TGFB1 Gene Wiki entry for DCP1A
|
Genomic Views for DCP1A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DCP1A gene promoter: GR p53 FOXD3 POU2F1 POU2F1a POU2F1b FOXO1a POU2F1c GR-alpha FOXO1 Other transcription factors
Search SABiosciences Chromatin IP Primers for DCP1A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCP1A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p21.1 Ensembl cytogenetic band: 3p21.1 HGNC cytogenetic band: 3p21.1DCP1A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M053319: view genomic region
(about GC identifiers)
Start:
|
53,317,443 bp from pter |
End:
|
53,381,654 bp from pter |
Size:
|
64,212 bases |
Orientation:
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minus strand |
|
Proteins for DCP1A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6 (See
protein sequence)Recommended Name: mRNA-decapping enzyme 1A Size: 582 amino acids; 63309 Da
Subunit: Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3. BindsDCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including XRN1 andLSM1. Interacts with PNRC2. Interacts with DDX17 in an RNA-independent manner. Interacts with ZC3HAV1
Subcellular location: Cytoplasm, P-body. Nucleus. Note=Co-localizes with NANOS3 in the processing bodies (Bysimilarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation tothe nucleus depends on interaction with SMAD4
1 PDB 3D structure from and Proteopedia for DCP1A:2WX3 (3D)
 Explore the universe of human proteins at neXtProt for DCP1A: NX_Q9NPI6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NPI6 DCP1A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060873.4 Reactome Protein details: Q9NPI6 Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
DCP1A for ontologies About GeneDecksing
DCP1A Antibody Products: Assay Products for DCP1A: |
Protein
Domains / Families for DCP1A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCP1A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9NPI6ProtoNet protein and cluster: Q9NPI6 UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6Similarity: Belongs to the DCP1 family |
Function for DCP1A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6Function: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay.Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP.Contributes to the transactivation of target genes after stimulation by TGFB1Enzyme Number (IUBMB): EC 3.-.-.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCP1A (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCP1A (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1A |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
DCP1A for ontologies About GeneDecksing
|
Pathways & Interactions for DCP1A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Deadenylation-dependent mRNA decay | | | 2 | Metabolism of mRNA | | | 3 | Destabilization of mRNA by Tristetraprolin (TTP) | | | 4 | TGF-beta Receptor Signaling Pathway | | | 5 | Regulation of nuclear SMAD2/3 signaling | |
Pathway sources See GeneCards unified pathways Show all pathways
2 BioSystems Pathways for DCP1A 
5/8
Reactome Pathways for DCP1A (see all 8)
1
Kegg Pathway (Kegg details for DCP1A):
DCP1A for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DCP1A
5/22 Interacting proteins for DCP1A (Q9NPI61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 22)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
IEA | -- | | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0010467 | gene expression |
TAS | -- | | GO:0016070 | RNA metabolic process |
TAS | -- | | GO:0016071 | mRNA metabolic process |
TAS | -- |
DCP1A for ontologies About GeneDecksing
|
Drugs & Compounds for DCP1A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for DCP1A Search CenterWatch for drugs/clinical trials and news about DCP1A 
|
Transcripts for DCP1A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for DCP1A gene: NM_018403.5 Unigene Cluster for DCP1A: DCP1 decapping enzyme homolog A (S. cerevisiae) Hs.476353 [show with all ESTs]Unigene Representative Sequence: NM_0184037 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000480258(uc021wzi.1 uc021wzk.1) ENST00000558034 ENST00000494659 ENST00000560624 ENST00000559748 ENST00000560076 ENST00000294241
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCP1A (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCP1A (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DCP1A (NM_018403) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCP1A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCP1A  |
Additional cDNA sequence: AB075507.1 AJ275986.1 AK001969.1 AK025344.1 AK295205.1 AY146651.1 BC007439.2 BC016729.1 16 DOTS entries: DT.212116 DT.95368399 DT.411082 DT.40203816 DT.95205735 DT.95205738 DT.100023689 DT.120906399 DT.40215942 DT.75120120 DT.92433512 DT.92433513 DT.120906364 DT.97843732 DT.435402 DT.99972833 24/181 AceView cDNA sequences (see all 181): BE550771 BG765088 AJ275986 BP345308 BI769171 BC007439 BP372052 CA390869 AA908493 BM695656 AI305162 BQ955536 AA872623 NM_018403 BP345417 CR625787 BI760514 AU121794 BX091268 BG393512 CB131324 BG944389 BF378804 BE047971 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for DCP1A About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for DCP1A
|
Expression for DCP1A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCP1A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TTTTAAAATG
About this image See DCP1A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DCP1A
SOURCE GeneReport for Unigene cluster: Hs.476353 UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6Tissue specificity: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas SABiosciences Custom PCR Arrays for DCP1A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCP1A Browse OriGene validated miRNA SYBR primer pairs
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| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1A |
Orthologs for DCP1A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DCP1A gene from 5/9 species (see all 9) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
mouse (Mus musculus) |
Mammalia |
Dcp1a1 , 5 |
DCP1 decapping enzyme homolog A (S. cerevisiae)1, 5 |
88.41(n)1 89.5(a)1 |
  |
14 (18.75 cM)5 759011 NM_133761.31 NP_598522.31 304795655 |
chicken (Gallus gallus) |
Aves |
DCP1A1 |
DCP1 decapping enzyme homolog A (S. cerevisiae) |
68.9(n) 62.26(a) |
  |
415992 XM_001233130.2 XP_001233131.2 |
tropical clawed frog (Xenopus tropicalis) |
Amphibia |
Str.195262 |
Transcribed sequence with moderate similarity to protein more |
79.31(n) |
  |
AL846059.2 |
zebrafish (Danio rerio) |
Actinopterygii |
mitc12 |
MAD homolog 4 interacting transcription coactivator more |
74.91(n) |
  |
360153 AJ344448.1 |
mosquito (Anopheles gambiae) |
Insecta |
AgaP_AGAP0126451 |
AGAP012645-PA |
43.88(n) 29.22(a) |
  |
4397654 XM_001230449.2 XP_001230450.2 |
ENSEMBL Gene Tree for DCP1A (if available) TreeFam Gene Tree for DCP1A (if available)  |
Paralogs for DCP1A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| -- |
Genomic Variants for DCP1A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 3 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for DCP1A (53317443 - 53381654 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for DCP1A 1 CNV: 36156  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCP1A |
|
Disorders
/ Diseases for DCP1A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DCP1A for disorders About GeneDecksing
OMIM gene information: 607010
OMIM disorders: --
3 diseases for DCP1A: About MalaCardsprimary biliary cirrhosis amyotrophic lateral sclerosis lateral sclerosis Human Genome Epidemiology (HuGE) Navigator: DCP1A (1 document) Export disorders for DCP1A gene to outside databases
|
Publications for DCP1A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCP1A gene, integrated from 9 sources (see all 40): (articles sorted by number of sources associating them with DCP1A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PubMed id 19150429)1, 2 Cho H.... Kim Y.K. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)1, 2 Fenger-Groen M.... Lykke-Andersen J. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PubMed id 12417715)1, 2 Lykke-Andersen J. (2002)
- The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)1, 2 Ingelfinger D....Achsel T. (2002)
- SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. (PubMed id 11836524)1, 2 Bai R.-Y.... Duyster J. (2002)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Retroviral GAG proteins recruit AGO2 on viral RNAs wit hout affecting RNA accumulation and translation. (PubMed id 21948796)1 Bouttier M....Lecellier C.H. (2012)
|
External Searches for DCP1A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DCP1A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCP1A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCP1A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for DCP1A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCP1A gene: Search GeneIP for patents involving DCP1A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for DCP1A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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