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DCP1A Gene

protein-coding   GIFtS: 58
GCID: GC03M053319

Decapping MRNA 1A

(Previous name: DCP1 decapping enzyme homolog A (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Decapping MRNA 1A1 2     SMAD4IP12
SMIF2 3 5     DCP1 Decapping Enzyme Homolog A2
Transcription Factor SMIF2 3     Decapping Enzyme HDcp1a2
Smad4-Interacting Transcriptional Co-Activator2 3     MRNA-Decapping Enzyme 1A2
DCP1 Decapping Enzyme Homolog A (S. Cerevisiae)1     Putative Protein Product Of Nbla003602
HSA2759862     EC 3.-.-.-3
Nbla003602     

External Ids:    HGNC: 187141   Entrez Gene: 558022   Ensembl: ENSG000001622907   OMIM: 6070105   UniProtKB: Q9NPI63   

Export aliases for DCP1A gene to outside databases

Previous GC identifer: GC03M053297


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCP1A Gene:
Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping
enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the
nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This
protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in
multiple transcript variants. (provided by RefSeq, Feb 2014)

GeneCards Summary for DCP1A Gene:
DCP1A (decapping mRNA 1A) is a protein-coding gene. GO annotations related to this gene include hydrolase activity and identical protein binding. An important paralog of this gene is DCP1B.

UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6
Function: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA
decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment
and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1

Gene Wiki entry for DCP1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCP1A gene promoter:
         GR   p53   FOXD3   POU2F1   POU2F1a   POU2F1b   FOXO1a   POU2F1c   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCP1A promoter sequence
   Search Chromatin IP Primers for DCP1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCP1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.1   Ensembl cytogenetic band:  3p21.1   HGNC cytogenetic band: 3p21.1

DCP1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCP1A gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M053319:  view genomic region     (about GC identifiers)

Start:
53,317,443 bp from pter      End:
53,381,654 bp from pter
Size:
64,212 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6 (See protein sequence)
Recommended Name: mRNA-decapping enzyme 1A  
Size: 582 amino acids; 63309 Da
Subunit: Forms a complex with EDC3, DCP2, DDX6 and EDC4/HEDLS, within this complex directly interacts with EDC3.
Binds DCP1B, UPF1 and SMAD4. Part of a cytoplasmic complex containing proteins involved in mRNA decay, including
XRN1 and LSM1. Interacts with PNRC2. Interacts with DDX17 in an RNA-independent manner. Interacts with ZC3HAV1
2 PDB 3D structures from and Proteopedia for DCP1A:
2WX3 (3D)        4B6H (3D)    

Explore the universe of human proteins at neXtProt for DCP1A: NX_Q9NPI6

Explore proteomics data for DCP1A at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys17
  • Modification sites at PhosphoSitePlus

  • See DCP1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001277133.1  NP_001277134.1  NP_001277135.1  NP_001277136.1  NP_060873.4  

    ENSEMBL proteins: 
     ENSP00000475920   ENSP00000476046   ENSP00000476219  
    Reactome Protein details: Q9NPI6

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR011993 PH_like_dom
     IPR010334 DCP1

    Graphical View of Domain Structure for InterPro Entry Q9NPI6

    ProtoNet protein and cluster: Q9NPI6

    UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6
    Similarity: Belongs to the DCP1 family


    Find genes that share domains with DCP1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCP1A_HUMAN, Q9NPI6
    Function: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA
    decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment
    and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1

         Enzyme Number (IUBMB): EC 3.-.-.-1

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI12417715
    GO:0016787hydrolase activity IEA--
    GO:0042802identical protein binding IPI16364915
         
    Find genes that share ontologies with DCP1A           About GenesLikeMe


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCP1A_HUMAN, Q9NPI6: Cytoplasm, P-body. Nucleus. Note=Co-localizes with NANOS3 in the processing bodies (By
    similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation
    to the nucleus depends on interaction with SMAD4
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    Find genes that share ontologies with DCP1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCP1A About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    mRNA Decay by 5 to 3' Exoribonuclease0.00
    RNA degradation0.48
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    Destabilization of mRNA by Tristetraprolin (TTP)0.00
    Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)0.00
    3Gene Expression
    Gene Expression0.40
    4TGF-beta Receptor Signaling Pathway
    TGF-beta Receptor Signaling Pathway
    5Regulation of nuclear SMAD2/3 signaling
    Regulation of nuclear SMAD2/3 signaling


    Find genes that share SuperPaths with DCP1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for DCP1A
        TGF-beta Receptor Signaling Pathway
    Regulation of nuclear SMAD2/3 signaling


    3 Reactome Pathways for DCP1A
        Tristetraprolin (TTP) destabilizes mRNA
    Butyrate Response Factor 1 (BRF1) destabilizes mRNA
    mRNA decay by 5' to 3' exoribonuclease


    1 Kegg Pathway  (Kegg details for DCP1A):
        RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCP1A
    Interactions:

        GeneGlobe Interaction Network for DCP1A

    Selected Interacting proteins for DCP1A (Q9NPI61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCP2Q8IU601, 3EBI-374238,EBI-521577 I2D: score=3 
    SMAD4Q134852, 3MINT-61961 I2D: score=3 
    UPF1Q929001, 3EBI-374238,EBI-373471 I2D: score=2 
    DDX6P261961, 3EBI-374238,EBI-351257 I2D: score=1 
    TIA1P314832, 3MINT-7711192 I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0010467gene expression TAS--
    GO:0016070RNA metabolic process TAS--
    GO:0016071mRNA metabolic process TAS--

    Find genes that share ontologies with DCP1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DCP1A



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCP1A gene (5 alternative transcripts): 
    NM_001290204.1  NM_001290205.1  NM_001290206.1  NM_001290207.1  NM_018403.6  

    Unigene Cluster for DCP1A:

    DCP1 decapping enzyme homolog A (S. cerevisiae)
    Hs.476353  [show with all ESTs]
    Unigene Representative Sequence: NM_018403
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000480258(uc021wzi.1 uc021wzk.1) ENST00000558034 ENST00000494659
    ENST00000560624 ENST00000559748 ENST00000560076 ENST00000607628 ENST00000294241
    ENST00000606822
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    hsa-miR-520f hsa-miR-376b hsa-miR-128 hsa-miR-92b hsa-miR-3622a-5p hsa-miR-34c-5p hsa-miR-32 hsa-miR-548y
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    Additional mRNA sequence: 

    AB075507.1 AJ275986.1 AK001969.1 AK025344.1 AK295205.1 AY146651.1 BC007439.2 BC016729.1 

    16 DOTS entries:

    DT.212116  DT.95368399  DT.411082  DT.40203816  DT.95205735  DT.95205738  DT.100023689  DT.120906399 
    DT.40215942  DT.75120120  DT.92433512  DT.92433513  DT.120906364  DT.97843732  DT.435402  DT.99972833 

    Selected AceView cDNA sequences (see all 181):

    CR625787 AA908493 BG765088 BQ955536 AU121794 AI674264 BE047971 BF378804 
    CF552214 BP345308 CA390869 BX091268 CB961072 CR602138 BG393512 BI760514 
    BI769171 CB131324 AJ275986 AA872623 BG944389 BC007439 AA346447 BM477910 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DCP1A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11
    SP1:                                                              -     -               
    SP2:                                      -                                             
    SP3:                                                                                    


    ECgene alternative splicing isoforms for DCP1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCP1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTAAAATG
    DCP1A Expression
    About this image


    DCP1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Epithelial Cells
             Fetal Matrix Cells Hair Follicle
     
     Hair (Integumentary System)
             Fetal Matrix Cells Hair Follicle
    DCP1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCP1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.476353

    UniProtKB/Swiss-Prot: DCP1A_HUMAN, Q9NPI6
    Tissue specificity: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCP1A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DCP1A gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcp1a1 , 5 DCP1 decapping enzyme homolog A (S. cerevisiae)1, 5 88.41(n)1
    89.5(a)1
      14 (18.75 cM)5
    759011  NM_133761.31  NP_598522.31 
     304795655 
    chicken
    (Gallus gallus)
    Aves DCP1A1 DCP1 decapping enzyme homolog A (S. cerevisiae) 68.07(n)
    61.23(a)
      415992  XM_004944566.1  XP_004944623.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCP1A6
    decapping mRNA 1A
    51(a)
    1 ↔ 1
    2(160094840-160140404)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.195262 Transcribed sequence with moderate similarity to protein more 79.31(n)    AL846059.2 
    zebrafish
    (Danio rerio)
    Actinopterygii mitc12 MAD homolog 4 interacting transcription coactivator more 74.91(n)   360153  AJ344448.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dcp16
    Decapping protein 1
    29(a)
    1 → many
    2R(19776465-19777788)
    worm
    (Caenorhabditis elegans)
    Secernentea dcap-16
    Protein DCAP-1 (dcap-1) mRNA, complete cds
    19(a)
    1 → many
    IV(1052511-1054794) WBGene00021929


    ENSEMBL Gene Tree for DCP1A (if available)
    TreeFam Gene Tree for DCP1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCP1A gene
    DCP1B2  
    1 SIMAP similar gene for DCP1A using alignment to 4 protein entries:     DCP1A_HUMAN (see all proteins):
    Nbla00360

    Find genes that share paralogs with DCP1A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCP1A (see all 1300)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1470113961,2
    C--53249411(+) AAGGTC/TGGGTA 1 -- ds50010--------
    rs1382441261,2
    C--53249444(+) GGGCCA/GCTGTC 1 -- ds50010--------
    rs561251651,2
    C--53249462(+) TGGTCC/TGTTGT 1 -- ds50013Minor allele frequency- T:0.21NA EA 242
    rs1906208191,2
    --53249605(+) GACATC/TGTAGC 1 -- ds50010--------
    rs1495347431,2
    --53249725(+) ATCCCA/GTTTCA 1 -- ds50010--------
    rs1438951431,2
    C--53250004(+) CTTGCG/TGTAAT 1 -- ut310--------
    rs1481879251,2
    C--53250114(+) CATTTA/GGAACA 1 -- ut310--------
    rs1822266651,2
    --53250423(+) TTCCAC/GAAGAT 1 -- ut310--------
    rs1847625091,2
    --53250437(+) CTGAAC/TGCAAC 1 -- ut310--------
    rs1412167911,2
    --53250518(+) GCGCAA/CCCTAG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DCP1A (53317443 - 53381654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DCP1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3825CNV Insertion18451855
    nsv834699CNV Loss17160897
    nsv517233CNV Loss19592680
    dgv5139n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607010    OMIM disorders: --


    Find genes that share disorders with DCP1A           About GenesLikeMe

    Genetic Association Database (GAD): DCP1A
    Human Genome Epidemiology (HuGE) Navigator: DCP1A (1 document)

    Export disorders for DCP1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCP1A gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with DCP1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human proline-rich nuclear receptor coregulatory protein 2 mediates an interaction between mRNA surveillance machinery and decapping complex. (PubMed id 19150429)1, 2 Cho H.... Kim Y.K. (Mol. Cell 2009)
    2. New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background. (PubMed id 18513389)1, 4 Penco S....Grossi E. (BMC Bioinformatics 2008)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    4. Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. (PubMed id 16364915)1, 2 Fenger-Groen M.... Lykke-Andersen J. (Mol. Cell 2005)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. (PubMed id 12417715)1, 2 Lykke-Andersen J. (Mol. Cell. Biol. 2002)
    8. The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci. (PubMed id 12515382)1, 2 Ingelfinger D.... Achsel T. (RNA 2002)
    9. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFbeta signalling. (PubMed id 11836524)1, 2 Bai R.-Y.... Duyster J. (Nat. Cell Biol. 2002)
    10. Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. (PubMed id 23583979)1 den Hoed M....Loos R.J. (Nat. Genet. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55802 HGNC: 18714 AceView: HSA275986 Ensembl:ENSG00000162290 euGenes: HUgn55802
    ECgene: DCP1A Kegg: 55802 H-InvDB: DCP1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCP1A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCP1A gene:
    Search GeneIP for patents involving DCP1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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