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Aliases for DCN Gene

Aliases for DCN Gene

  • Decorin 2 3
  • Decorin Proteoglycan 2 3
  • Bone Proteoglycan II 3 4
  • SLRR1B 3 4
  • PG-S2 3 4
  • PG40 3 4
  • Dermatan Sulphate Proteoglycans II 3
  • Small Leucine-Rich Protein 1B 3
  • Proteoglycan Core Protein 3
  • DSPG2 3
  • PGII 3
  • CSCD 3
  • PGS2 3

External Ids for DCN Gene

Previous GeneCards Identifiers for DCN Gene

  • GC12M090861
  • GC12M091986
  • GC12M091472
  • GC12M090041
  • GC12M088606

Summaries for DCN Gene

Entrez Gene Summary for DCN Gene

  • This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for DCN Gene

DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include corneal dystrophy, congenital stromal and posterior amorphous corneal dystrophy. Among its related pathways are Infectious disease and Degradation of the extracellular matrix. GO annotations related to this gene include poly(A) RNA binding and collagen binding. An important paralog of this gene is ECM2.

UniProtKB/Swiss-Prot for DCN Gene

  • May affect the rate of fibrils formation

Gene Wiki entry for DCN Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCN Gene

Genomics for DCN Gene

Regulatory Elements for DCN Gene

Transcription factor binding sites by QIAGEN in the DCN gene promoter:

Genomic Location for DCN Gene

Chromosome:
12
Start:
91,140,484 bp from pter
End:
91,183,123 bp from pter
Size:
42,640 bases
Orientation:
Minus strand

Genomic View for DCN Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCN Gene

Proteins for DCN Gene

  • Protein details for DCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07585-PGS2_HUMAN
    Recommended name:
    Decorin
    Protein Accession:
    P07585
    Secondary Accessions:
    • Q9P0Z0
    • Q9P0Z1
    • Q9Y5N8
    • Q9Y5N9

    Protein attributes for DCN Gene

    Size:
    359 amino acids
    Molecular mass:
    39747 Da
    Quaternary structure:
    • Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).

    Alternative splice isoforms for DCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCN Gene

Proteomics data for DCN Gene at MOPED

Post-translational modifications for DCN Gene

  • The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin
  • Glycosylation at Ser 34, Asn 211, Asn 262, and Asn 303
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DCN Gene

Domains & Families for DCN Gene

Gene Families for DCN Gene

Suggested Antigen Peptide Sequences for DCN Gene

Graphical View of Domain Structure for InterPro Entry

P07585

UniProtKB/Swiss-Prot:

PGS2_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
  • Contains 12 LRR (leucine-rich) repeats.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Similarity:
  • Contains 12 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with DCN: view

Function for DCN Gene

Molecular function for DCN Gene

GENATLAS Biochemistry:
decorin,small collagen-binding proteoglycan of the extracellular matrix,leucine-rich repeats (LRR) family,involved in the differentiation of retinal glanglion cells
UniProtKB/Swiss-Prot Function:
May affect the rate of fibrils formation

Gene Ontology (GO) - Molecular Function for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005518 collagen binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0047485 protein N-terminus binding IEA --
genes like me logo Genes that share ontologies with DCN: view
genes like me logo Genes that share phenotypes with DCN: view

Animal Models for DCN Gene

MGI Knock Outs for DCN:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCN

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for DCN Gene

Localization for DCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCN Gene COMPARTMENTS Subcellular localization image for DCN gene
Compartment Confidence
extracellular 5
golgi apparatus 4
lysosome 4
vacuole 4
cytoskeleton 2
plasma membrane 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix --
GO:0005589 collagen type VI trimer IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with DCN: view

Pathways & Interactions for DCN Gene

genes like me logo Genes that share pathways with DCN: view

Pathways by source for DCN Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0001890 placenta development IEA --
GO:0005975 carbohydrate metabolic process TAS --
GO:0007519 skeletal muscle tissue development IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with DCN: view

No data available for SIGNOR curated interactions for DCN Gene

Drugs & Compounds for DCN Gene

(25) Drugs for DCN Gene - From: NovoSeek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bleomycin Approved Pharma 142
Carboplatin Approved Pharma Antitumor agent that forms platinum-DNA adducts., Platinum 1812
Chloramphenicol Approved Pharma 6
Chlorpromazine Approved Pharma Channel blocker 13
Dexamethasone Approved, Investigational Pharma Agonist 1806

(46) Additional Compounds for DCN Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AG 1478
Agarose
ALGINATE
aspartate
beta-D-Xyloside
genes like me logo Genes that share compounds with DCN: view

Transcripts for DCN Gene

Unigene Clusters for DCN Gene

Decorin:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCN

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: -
SP17: - -

ExUns: 12d · 12e ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c · 16d · 16e
SP1:
SP2:
SP3:
SP4:
SP5: - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DCN Gene

GeneLoc Exon Structure for
DCN
ECgene alternative splicing isoforms for
DCN

Expression for DCN Gene

mRNA expression in normal human tissues for DCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCN Gene

This gene is overexpressed in Urinary Bladder (8.0) and Nasopharynx (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCN Gene



SOURCE GeneReport for Unigene cluster for DCN Gene Hs.156316

genes like me logo Genes that share expression patterns with DCN: view

Protein tissue co-expression partners for DCN Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCN Gene

Orthologs for DCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCN Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCN 35
  • 88.83 (n)
  • 90.78 (a)
DCN 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCN 35
  • 90.41 (n)
  • 93.58 (a)
DCN 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcn 35
  • 80.7 (n)
  • 81.64 (a)
Dcn 16
Dcn 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCN 35
  • 99.81 (n)
  • 100 (a)
DCN 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcn 35
  • 78.91 (n)
  • 79.1 (a)
oppossum
(Monodelphis domestica)
Mammalia DCN 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCN 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCN 35
  • 75.35 (n)
  • 78.15 (a)
DCN 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCN 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcn 35
  • 70.76 (n)
  • 75.7 (a)
Str.8982 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24505 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
dcn 35
  • 66.85 (n)
  • 67.69 (a)
dcn 36
  • 65 (a)
OneToOne
Species with no ortholog for DCN:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCN Gene

ENSEMBL:
Gene Tree for DCN (if available)
TreeFam:
Gene Tree for DCN (if available)

Paralogs for DCN Gene

Paralogs for DCN Gene

genes like me logo Genes that share paralogs with DCN: view

Variants for DCN Gene

Sequence variations from dbSNP and Humsavar for DCN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs3343 -- 91,145,685(-) TTAGC(C/T)CATTT utr-variant-3-prime
rs7441 -- 91,145,898(-) AATTG(C/T)CTACA utr-variant-3-prime
rs12310 -- 91,146,212(-) TGGAT(C/T)AAGTG reference, missense, utr-variant-3-prime
rs491181 -- 91,170,575(-) GAGCA(C/G)TTTTT intron-variant
rs491237 -- 91,152,736(-) GAATT(A/T)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCN Gene

Variant ID Type Subtype PubMed ID
nsv899425 CNV Gain 21882294
nsv899429 CNV Loss 21882294
dgv210n27 CNV Loss 19166990
nsv832484 CNV Gain+Loss 17160897
nsv899430 CNV Gain 21882294

Variation tolerance for DCN Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCN Gene

HapMap Linkage Disequilibrium report
DCN
Human Gene Mutation Database (HGMD)
DCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCN Gene

Disorders for DCN Gene

MalaCards: The human disease database

(28) MalaCards diseases for DCN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
corneal dystrophy, congenital stromal
  • congenital stromal corneal dystrophy
posterior amorphous corneal dystrophy
  • pacd
interstitial keratitis
neonatal marfan syndrome
  • neonatal mfs
localized scleroderma
  • circumscribed scleroderma
- elite association
Search DCN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PGS2_HUMAN
  • Corneal dystrophy, congenital stromal (CSCD) [MIM:610048]: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DCN

Genetic Association Database (GAD)
DCN
Human Genome Epidemiology (HuGE) Navigator
DCN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCN
genes like me logo Genes that share disorders with DCN: view

No data available for Genatlas for DCN Gene

Publications for DCN Gene

  1. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. (PMID: 8432526) Danielson K.G. … Iozzo R.V. (Genomics 1993) 2 23 67
  2. Decreased gene expression of fibrillin-1 in stress urinary incontinence. (PMID: 19358237) SAPderberg M.W. … Ekman-Ordeberg G. (Neurourol. Urodyn. 2010) 23 67
  3. Involvement of a cysteine protease in the secretion process of human xylosyltransferase I. (PMID: 20198421) PAPnighaus C. … GAPtting C. (Glycoconj. J. 2010) 23 67
  4. Micromass culture of human anulus cells: morphology and extracellular matrix production. (PMID: 20139802) Gruber H.E. … Hanley E.N. (Spine 2010) 23 67
  5. Syndecan-2 and decorin: proteoglycans with a difference--implications in keloid pathogenesis. (PMID: 20386290) Mukhopadhyay A. … Phan T.T. (J Trauma 2010) 23 67

Products for DCN Gene

Sources for DCN Gene

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