Aliases for DCN Gene
External Ids for DCN Gene
Previous GeneCards Identifiers for DCN Gene
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]
GeneCards Summary for DCN Gene
DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include Corneal Dystrophy, Congenital Stromal and Stromal Dystrophy. Among its related pathways are ECM proteoglycans and BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation. GO annotations related to this gene include poly(A) RNA binding and collagen binding. An important paralog of this gene is BGN.
UniProtKB/Swiss-Prot for DCN Gene
May affect the rate of fibrils formation.