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DCN Gene

protein-coding   GIFtS: 69
GCID: GC12M091472

Decorin

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
decorin1 2     DSPG22
Decorin Proteoglycan1 2     PGII2
Bone Proteoglycan II2 3     PGS22
PG-S22 3     Dermatan Sulphate Proteoglycans II2
PG402 3     Proteoglycan Core Protein2
SLRR1B2 3     Small Leucine-Rich Protein 1B2
CSCD2 5     

External Ids:    HGNC: 27051   Entrez Gene: 16342   Ensembl: ENSG000000114657   OMIM: 1252555   UniProtKB: P075853   

Export aliases for DCN gene to outside databases

Previous GC identifers: GC12M090861 GC12M091986 GC12M090041 GC12M088606


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCN Gene:
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related
in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene
duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role
in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the
growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this
gene. This gene is a candidate gene for Marfan syndrome. (provided by RefSeq, Jul 2008)

GeneCards Summary for DCN Gene:
DCN (decorin) is a protein-coding gene. Diseases associated with DCN include burn scar, and congenital stromal corneal dystrophy. GO annotations related to this gene include glycosaminoglycan binding and protein N-terminus binding. An important paralog of this gene is PODN.

UniProtKB/Swiss-Prot: PGS2_HUMAN, P07585
Function: May affect the rate of fibrils formation

Gene Wiki entry for DCN (Decorin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCN gene promoter:
         AP-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DCN promoter sequence
   Search Chromatin IP Primers for DCN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q21.33   Ensembl cytogenetic band:  12q21.33   HGNC cytogenetic band: 12q23

DCN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCN gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M091472:  view genomic region     (about GC identifiers)

Start:
91,539,025 bp from pter      End:
91,576,900 bp from pter
Size:
37,876 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PGS2_HUMAN, P07585 (See protein sequence)
Recommended Name: Decorin precursor  
Size: 359 amino acids; 39747 Da
Subunit: Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and
ELN. Interacts with DPT (By similarity)
Secondary accessions: Q9P0Z0 Q9P0Z1 Q9Y5N8 Q9Y5N9
Alternative splicing: 5 isoforms:  P07585-1   P07585-2   P07585-3   P07585-4   P07585-5   

Explore the universe of human proteins at neXtProt for DCN: NX_P07585

Explore proteomics data for DCN at MOPED

Post-translational modifications: 

  • The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the
    tissue of origin1
  • Glycosylation2 at Ser34, Asn211, Asn262, Asn303
  • Modification sites at PhosphoSitePlus

  • See DCN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001911.1  NP_598010.1  NP_598011.1  NP_598012.1  NP_598013.1  NP_598014.1  

    ENSEMBL proteins: 
     ENSP00000052754   ENSP00000448853   ENSP00000447654   ENSP00000413723   ENSP00000399815  
     ENSP00000447674   ENSP00000446530   ENSP00000398514   ENSP00000449408   ENSP00000449782  
     ENSP00000447886   ENSP00000449014   ENSP00000449438   ENSP00000446527   ENSP00000448857  
     ENSP00000448057   ENSP00000448274   ENSP00000228329   ENSP00000302031   ENSP00000376862  
     ENSP00000401021  
    Reactome Protein details: P07585

    DCN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
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    OriGene MassSpec for DCN
    OriGene Custom Protein Services for DCN
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    Novus Biologicals DCN Lysates
    Sino Biological Recombinant Protein for DCN
    Sino Biological Cell Lysate for DCN
    ProSpec Recombinant Protein for DCN
    Cloud-Clone Corp. Proteins for DCN

    DCN Antibody Products:

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    LSBio Antibodies in human, mouse, rat for DCN

    DCN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DCN
    Cloud-Clone Corp. CLIAs for DCN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    SLRR: Proteoglycans / Extracellular Matrix : Small leucine-rich repeats

    5 InterPro protein domains:
     IPR001611 Leu-rich_rpt
     IPR003591 Leu-rich_rpt_typical-subtyp
     IPR028549 Decorin
     IPR000372 LRR-contain_N
     IPR016352 SLRP_I_decor/aspor/byglycan

    Graphical View of Domain Structure for InterPro Entry P07585

    ProtoNet protein and cluster: P07585

    2 Blocks protein domains:
    IPB000372 Cysteine-rich flanking region
    IPB001611 Leucine-rich repeat signature


    UniProtKB/Swiss-Prot: PGS2_HUMAN, P07585
    Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily
    Similarity: Contains 12 LRR (leucine-rich) repeats


    DCN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PGS2_HUMAN, P07585
    Function: May affect the rate of fibrils formation

         Genatlas biochemistry entry for DCN:
    decorin,small collagen-binding proteoglycan of the extracellular matrix,leucine-rich repeats (LRR) family,involved
    in the differentiation of retinal glanglion cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0005518collagen binding IEA--
    GO:0005539glycosaminoglycan binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0047485protein N-terminus binding IEA--
         
    DCN for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DCN:
     Increased gamma-H2AX phosphory 

         Selected MGI mutant phenotypes (inferred from 1 allele(MGI details for Dcn) (see all 18):
     behavior/neurological  cellular  craniofacial  digestive/alimentary  endocrine/exocrine gland 
     growth/size/body  hematopoietic system  homeostasis/metabolism  immune system  integument 
     mortality/aging  muscle  renal/urinary system  reproductive system  respiratory system 

    DCN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dcntm1Ioz for DCN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCN

    miRNA
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    Block miRNA regulation of human, mouse, rat DCN using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DCN:
    hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidDCN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DCN
    Predesigned siRNA for gene silencing in human, mouse, rat DCN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DCN

    Clone
    Products:
         
    OriGene clones in human, mouse for DCN (see all 35)
    OriGene ORF clones in mouse, rat for DCN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): DCN (NM_133507)
    Sino Biological Human cDNA Clone for DCN
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCN

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DCN
    ESI BIO PureStem Progenitors for DCN: 
    PureStem 7PEND24, NCr-fac & Meso-prx Progenitor, PureStem MEL2, NCr-fac Progenitor,
    PureStem SK11, NCr-fac & Meso-prx Progenitor, PureStem Z11, Meso Progenitor
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PGS2_HUMAN, P07585: Secreted, extracellular space, extracellular matrix
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus4
    lysosome4
    vacuole4
    cytoskeleton2
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005578proteinaceous extracellular matrix ----
    GO:0005589collagen type VI IEA--
    GO:0005615extracellular space IDA--
    GO:0005796Golgi lumen TAS--

    DCN for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCN About   (see all 12)                                                                                              See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1MPS VI - Maroteaux-Lamy syndrome
    MPS VI - Maroteaux-Lamy syndrome0.45
    MPS IIIB - Sanfilippo syndrome B0.45
    MPS IIIC - Sanfilippo syndrome C0.45
    MPS II - Hunter syndrome0.45
    MPS IV - Morquio syndrome A0.45
    Glycosaminoglycan metabolism0.45
    Mucopolysaccharidoses0.45
    MPS IV - Morquio syndrome B0.45
    2Chondroitin sulfate/dermatan sulfate metabolism
    Chondroitin sulfate/dermatan sulfate metabolism0.51
    CS/DS degradation0.00
    A tetrasaccharide linker sequence is required for GAG synthesis0.51
    Dermatan sulfate biosynthesis0.00
    Chondroitin sulfate biosynthesis0.41
    3Degradation of the extracellular matrix
    Degradation of the extracellular matrix0.43
    Extracellular matrix organization0.34
    4Heparan sulfate/heparin (HS-GAG) metabolism
    Heparan sulfate/heparin (HS-GAG) metabolism0.57
    5Metabolism
    Metabolism0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DCN
        Articular Cartilage Extracellular Matrix


    1 BioSystems Pathway for DCN
        Validated transcriptional targets of AP1 family members Fra1 and Fra2

    1 Sino Biological Pathway for DCN
        TGF-beta Signaling Pathway

    Selected Reactome Pathways for DCN (see all 6)
        Dermatan sulfate biosynthesis
    ECM proteoglycans
    Degradation of the extracellular matrix
    CS/DS degradation
    A tetrasaccharide linker sequence is required for GAG synthesis


    2 Kegg Pathways  (Kegg details for DCN):
        TGF-beta signaling pathway
    Proteoglycans in cancer


    DCN for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DCN: 
              Fibrosis in human mouse rat
              Cell Lineage Identification in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DCN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCN (P075853 ENSP000000527544) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228321P013753, ENSP000003928584I2D: score=2 STRING: ENSP00000392858
    TNFP013753, ENSP000003986984I2D: score=2 STRING: ENSP00000398698
    ENSG00000204490P013753I2D: score=2 
    ENSG00000206439P013753I2D: score=2 
    ENSG00000223952P013753I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEA--
    GO:0001890placenta development IEA--
    GO:0005975carbohydrate metabolic process TAS--
    GO:0007519skeletal muscle tissue development IEA--
    GO:0007568aging IEA--

    DCN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCN (PGS2)

    1 DrugBank Compound for DCN    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Tris(Hydroxymethyl)Aminomethane-- --target--17139284 17016423 10592235

    Selected Novoseek inferred chemical compound relationships for DCN gene (see all 70)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glycosaminoglycan 90.2 116 9726998 (5), 12372409 (4), 2108171 (3), 17651433 (3) (see all 73)
    dermatan sulfate 89.5 90 10536375 (4), 12531251 (2), 10749870 (2), 9727420 (2) (see all 61)
    chondroitin 89.3 60 1605630 (3), 1711290 (2), 19557760 (2), 1744124 (2) (see all 46)
    chondroitin sulfate 86.1 76 17286067 (6), 12531251 (3), 16498599 (3), 10536375 (3) (see all 50)
    dermatan 83.7 17 9168858 (2), 10749870 (1), 7741696 (1), 9148753 (1) (see all 12)
    keratan sulfate 82.8 11 8546427 (2), 20139802 (2), 1376375 (1), 8760363 (1) (see all 8)
    galactosaminoglycan 80.3 7 12495820 (1), 19444760 (1), 8635597 (1), 12668676 (1) (see all 5)
    dspg 79.3 11 8457255 (2), 16902402 (2), 1599405 (1), 10648661 (1) (see all 7)
    l-iduronate 78.8 1 12207034 (1)
    heparan sulfate 70.3 20 10585870 (2), 1639087 (1), 8397099 (1), 9328841 (1) (see all 16)



    DCN for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCN gene (6 alternative transcripts): 
    NM_001920.3  NM_133503.2  NM_133504.2  NM_133505.2  NM_133506.2  NM_133507.2  

    Unigene Cluster for DCN:

    Decorin
    Hs.156316  [show with all ESTs]
    Unigene Representative Sequence: NM_001920
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000052754(uc001tbo.3 uc001tbp.3 uc001tbq.3 uc001tbr.3 uc001tbu.3)
    ENST00000548218 ENST00000552962 ENST00000420120 ENST00000441303 ENST00000547568
    ENST00000546391 ENST00000456569 ENST00000550758 ENST00000547937 ENST00000552145
    ENST00000550563 ENST00000549513 ENST00000546370 ENST00000546745 ENST00000550099
    ENST00000551354 ENST00000548768
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate DCN:
    hsa-miR-374c hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmidDCN 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DCN
    Clone
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    OriGene clones in human, mouse for DCN (see all 35)
    OriGene ORF clones in mouse, rat for DCN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): DCN (NM_133507)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCN
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DCN
    OriGene qSTAR qPCR primer pairs in human, mouse for DCN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCN
      QuantiTect SYBR Green Assays in human, mouse, rat DCN
      QuantiFast Probe-based Assays in human, mouse, rat DCN

    Additional mRNA sequence: 

    AF138300.1 AF138301.1 AF138302.1 AF138303.1 AF138304.1 AK291309.1 AL355731.1 BC005322.1 
    BT019800.1 BX571756.1 CR407676.1 CR541946.1 

    Selected DOTS entries (see all 66):

    DT.92468924  DT.99954679  DT.100891103  DT.100042199  DT.95305589  DT.100806878  DT.100032839  DT.100891123 
    DT.100723534  DT.92468934  DT.100733720  DT.100042195  DT.100891111  DT.100042205  DT.95305581  DT.100891114 
    DT.92468931  DT.95305642  DT.121111226  DT.405392  DT.100891081  DT.92468868  DT.100891126  DT.100042193 

    Selected AceView cDNA sequences (see all 2381):

    AF138301 AA383731 CF528270 CA412018 AI754467 AA360149 CD679089 AA327690 
    BM994416 BQ950228 AA334020 BQ183116 BM919883 BX454280 CK820454 BQ719555 
    BQ181242 BM769289 CB857927 CA437201 CA414726 CN479883 AU136256 BQ445836 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCN (see all 17)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ·
    SP1:                          -     -     -     -     -     -     -     -     -     -                             -     -     -                                 
    SP2:                                                                                -                             -     -     -                                 
    SP3:                                                                                                              -     -     -                                 
    SP4:                                                                                                              -     -     -     -     -                     
    SP5:                          -     -     -     -     -     -     -     -     -     -                             -     -     -     -     -     -     -     -   

    ExUns: 12d · 12e ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c · 16d · 16e
    SP1:                                                                                    
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                                    
    SP5:  -     -     -     -                                                               


    ECgene alternative splicing isoforms for DCN

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCN expression in normal human tissues (normalized intensities)      DCN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTATTATG
    DCN Expression
    About this image


    DCN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 39) fully expand
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Bone (Muscoskeletal System)    fully expand to see all 10 entries
             Endochondral Osteoblasts Rostral Endochondral Facial Bones
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Dermis (Integumentary System)    fully expand to see all 6 entries
             Dermal Fibroblasts Dorsal Dermis
             Human Dermal Fibroblasts-adult (HDF-a)   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 7 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             HyStem+TGFbeta3+GDF5-induced 4D20.8 cells
     
     Tendon & Ligament (Muscoskeletal System)    fully expand to see all 4 entries
             Early Tenocyte Cells Limb Tendon Primordia
    DCN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.156316
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DCN: 
              Fibrosis in human mouse rat
              Cell Lineage Identification in human mouse rat
              TGFB/BMP Signaling Pathway in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for DCN
    OriGene qSTAR qPCR primer pairs in human, mouse for DCN
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    QuantiFast Probe-based Assays in human, mouse, rat DCN
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for DCN gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcn1 , 5 decorin1, 5 80.7(n)1
    81.64(a)1
      10 (50.27 cM)5
    131791  NM_007833.51  NP_031859.11 
     974795005 
    chicken
    (Gallus gallus)
    Aves DCN1 decorin 75.35(n)
    78.15(a)
      417892  NM_001030747.2  NP_001025918.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCN6
    decorin
    79(a)
    1 ↔ 1
    5(32290281-32332514)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.245052 Xenopus laevis transcribed sequence with moderate similarity more 73.75(n)    CB564863.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC044206.12   -- 75.07(n)   64698  BC044206.1 


    ENSEMBL Gene Tree for DCN (if available)
    TreeFam Gene Tree for DCN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCN gene
    PODN2  FLRT12  PODNL12  FMOD2  KERA2  PRELP2  FLRT32  OMD2  
    ASPN2  BGN2  FLRT22  ECM22  LOC1005090912  LUM2  
    Selected SIMAP similar genes for DCN using alignment to 12 protein entries:     PGS2_HUMAN (see all proteins) (see all similar genes):
    LRIG1    SLIT2    LGR5    ASPN    BGN    SLIT1
    PXDNL    LRRC3B    LGR6    AMIGO1    LRRC70    PXDN
    ZSCAN2    AMIGO3    SLIT3    PODN    LGR4    TRIL

    DCN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for DCN (see all 839)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1485726521,2
    --91381181(+) TCCACA/TGCACT 6 -- ds50010--------
    rs31382911,2
    C,F,H--91381588(-) TAGATG/ATATTA 6 -- ds500113Minor allele frequency- A:0.12NS EA NA WA 1324
    rs1467061151,2
    --91381723(+) TATAAG/TCTTAC 6 -- ut310--------
    rs1402988201,2
    --91381900(+) AGTAAC/TTTTGA 6 -- ut310--------
    rs353798121,2
    C,F--91382052(+) TCTCAA/GATGAG 6 -- ut311Minor allele frequency- G:0.03NA 120
    rs1832407981,2
    --91382081(+) ACAGAA/CGACTC 6 -- ut310--------
    rs31382901,2
    C,F,H--91382109(-) AATTTC/TCAGGA 6 -- ut31 ese37Minor allele frequency- T:0.02NS EA 556
    rs31382891,2
    C,F,H--91382239(-) GCCATT/CTTCAG 6 -- ut317Minor allele frequency- C:0.01NS EA NA 426
    rs74411,2
    C,F,A,H--91382269(-) AATTGC/TCTACA 6 -- ut31 ese322Minor allele frequency- T:0.08NS MN EA NA WA 2672
    rs1914347781,2
    --91382324(+) TAAAAC/TATCCA 6 -- ut310--------

    HapMap Linkage Disequilibrium report for DCN (91539025 - 91576900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DCN:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv210n27CNV Loss19166990
    nsv899429CNV Loss21882294
    nsv899430CNV Gain21882294
    nsv899425CNV Gain21882294
    nsv832484CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): DCN
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCN
    DNA2.0 Custom Variant and Variant Library Synthesis for DCN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 125255   
    OMIM disorders: 610048  
    UniProtKB/Swiss-Prot: PGS2_HUMAN, P07585
  • Corneal dystrophy, congenital stromal (CSCD) [MIM:610048]: A corneal dystrophy characterized by
    congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the
    stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. Note=The
    disease is caused by mutations affecting the gene represented in this entry

  • Selected diseases for DCN (see all 116):    About MalaCards
    burn scar    congenital stromal corneal dystrophy    marfan syndrome    neonatal marfan syndrome
    hypertrophic scars    posterior amorphous corneal dystrophy    keratopathy    gingival overgrowth
    crouzon syndrome    nephrogenic systemic fibrosis    localized scleroderma    bullous keratopathy
    odontogenic myxoma    myoma    peyronie's disease    peyronies disease
    tendinosis    keloids    pseudoachondroplasia    pseudoxanthoma elasticum

    3 diseases from the University of Copenhagen DISEASES database for DCN:
    Lyme disease     Ehlers-Danlos syndrome     Osteoarthritis

    DCN for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for DCN gene (see all 89)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    collagen fibril 82.8 67 18622092 (4), 17530890 (3), 2059554 (3), 17651433 (3) (see all 50)
    scars hypertrophic 61.1 23 9682679 (5), 19167828 (4), 17374457 (3), 10692030 (2) (see all 8)
    osteoarthritis 42.2 4 11406617 (1), 18620607 (1), 8456642 (1), 11597178 (1)
    scar 41.2 28 15312466 (5), 10692030 (3), 7544762 (2), 11039776 (2) (see all 13)
    ehlers-danlos syndrome 39 4 11532373 (1), 16583246 (1), 15859521 (1), 17651433 (1)
    bullous keratopathy 36.3 1 9727420 (1)
    psach 36 1 11691584 (1)
    osteosarcoma 34 16 18497961 (4), 18661352 (3), 18505923 (2), 2254344 (2) (see all 9)
    crouzon syndrome 33.9 1 10384983 (1)
    keloid 27.9 17 20386290 (6), 19268470 (6), 8949432 (1), 8262136 (1)

    GeneTests: DCN
    GeneReviews: DCN
    Genetic Association Database (GAD): DCN
    Human Genome Epidemiology (HuGE) Navigator: DCN (13 documents)

    Export disorders for DCN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCN gene, integrated from 10 sources (see all 811):
    (articles sorted by number of sources associating them with DCN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. (PubMed id 8432526)1, 2, 3, 9 Danielson K.G.... Iozzo R.V. (Genomics 1993)
    2. The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PubMed id 16902402)1, 4, 9 Wang I.J....Lin L.L. (Mol. Vis. 2006)
    3. The association of haplotype at the lumican gene with high myopia susceptibility in Taiwanese patients. (PubMed id 19616852)1, 4, 9 Chen Z.T....Lin L.L. (Ophthalmology 2009)
    4. Congenital stromal dystrophy of the cornea caused by a mutation in the decorin gene. (PubMed id 15671264)1, 2, 9 Bredrup C.... Boman H. (Invest. Ophthalmol. Vis. Sci. 2005)
    5. The Decorin gene 179 allelic variant is associated with a slower progression of renal disease in patients with type 1 diabetes. (PubMed id 12187087)1, 4, 9 De Cosmo S....Viberti G.C. (Nephron 2002)
    6. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PubMed id 21658281)1, 4 Aouizerat B.E....Tseng Z.H. (BMC Cardiovasc Disord 2011)
    7. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    10. Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter. (PubMed id 19590686)1, 4 Wilker E....Schwartz J. (Environ. Health Perspect. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1634 HGNC: 2705 AceView: DCN Ensembl:ENSG00000011465 euGenes: HUgn1634
    ECgene: DCN Kegg: 1634 H-InvDB: DCN

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCN Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DCN Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/dcn/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCN gene:
    Search GeneIP for patents involving DCN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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