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Aliases for DCN Gene

Aliases for DCN Gene

  • Decorin 2 3 3 5
  • Bone Proteoglycan II 3 4
  • SLRR1B 3 4
  • PG40 3 4
  • Dermatan Sulphate Proteoglycans II 3
  • Small Leucine-Rich Protein 1B 3
  • Proteoglycan Core Protein 3
  • Decorin Proteoglycan 2
  • DSPG2 3
  • PG-S2 4
  • CSCD 3
  • PGII 3
  • PGS2 3

External Ids for DCN Gene

Previous GeneCards Identifiers for DCN Gene

  • GC12M090861
  • GC12M091986
  • GC12M091472
  • GC12M090041
  • GC12M088606

Summaries for DCN Gene

Entrez Gene Summary for DCN Gene

  • This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

GeneCards Summary for DCN Gene

DCN (Decorin) is a Protein Coding gene. Diseases associated with DCN include Corneal Dystrophy, Congenital Stromal and Stromal Dystrophy. Among its related pathways are Degradation of the extracellular matrix and Validated transcriptional targets of AP1 family members Fra1 and Fra2. GO annotations related to this gene include poly(A) RNA binding and collagen binding. An important paralog of this gene is BGN.

UniProtKB/Swiss-Prot for DCN Gene

  • May affect the rate of fibrils formation.

Gene Wiki entry for DCN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCN Gene

Genomics for DCN Gene

Regulatory Elements for DCN Gene

Enhancers for DCN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G091138 1.1 Ensembl ENCODE dbSUPER 11.3 +42.4 42352 5.4 JUN CEBPB FEZF1 ZNF384 EP300 ZNF507 STAT3 FOS FOXP2 MAFK LUM DCN KERA LOC105369897
GH12G091216 0.4 ENCODE 20.8 -33.9 -33936 0.2 RAD51 DCN LUM ENSG00000258148 LOC105369897
GH12G091272 0.8 Ensembl ENCODE 10.1 -91.1 -91115 3.7 GATA3 PKNOX1 RFX1 POLR2A SMARCA4 RAD21 NR2F2 DCN LOC105369897 ENSG00000258148
GH12G091249 0.6 ENCODE 10.3 -67.0 -66977 2.2 MAFF ZNF316 CEBPB CEBPG KDM1A EMSY MAFK DCN ENSG00000258148 LOC105369897
GH12G091357 0.6 ENCODE 10.2 -174.5 -174480 1.1 ELF3 PKNOX1 NFYC EP300 CTBP1 JUND HNF4G HNF4A HOMEZ LUM DCN LOC105369898 GC12M091347
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCN on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DCN gene promoter:

Genomic Location for DCN Gene

Chromosome:
12
Start:
91,140,484 bp from pter
End:
91,183,123 bp from pter
Size:
42,640 bases
Orientation:
Minus strand

Genomic View for DCN Gene

Genes around DCN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCN Gene

Proteins for DCN Gene

  • Protein details for DCN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07585-PGS2_HUMAN
    Recommended name:
    Decorin
    Protein Accession:
    P07585
    Secondary Accessions:
    • Q9P0Z0
    • Q9P0Z1
    • Q9Y5N8
    • Q9Y5N9

    Protein attributes for DCN Gene

    Size:
    359 amino acids
    Molecular mass:
    39747 Da
    Quaternary structure:
    • Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT (By similarity).

    Alternative splice isoforms for DCN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCN Gene

Post-translational modifications for DCN Gene

  • The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
  • Glycosylation at Ser34, Asn211, isoforms=2, 3262, and Asn303
  • Modification sites at PhosphoSitePlus

Antibody Products

Protein Products

Assay Products

  • Cloud-Clone Corp. Assay Kits for DCN

No data available for DME Specific Peptides for DCN Gene

Domains & Families for DCN Gene

Gene Families for DCN Gene

Suggested Antigen Peptide Sequences for DCN Gene

Graphical View of Domain Structure for InterPro Entry

P07585

UniProtKB/Swiss-Prot:

PGS2_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.
genes like me logo Genes that share domains with DCN: view

Function for DCN Gene

Molecular function for DCN Gene

GENATLAS Biochemistry:
decorin,small collagen-binding proteoglycan of the extracellular matrix,leucine-rich repeats (LRR) family,involved in the differentiation of retinal glanglion cells
UniProtKB/Swiss-Prot Function:
May affect the rate of fibrils formation.

Gene Ontology (GO) - Molecular Function for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0004860 protein kinase inhibitor activity IBA --
GO:0005515 protein binding IPI 1747115
GO:0005518 collagen binding IEA --
GO:0005539 glycosaminoglycan binding IEA --
genes like me logo Genes that share ontologies with DCN: view
genes like me logo Genes that share phenotypes with DCN: view

Human Phenotype Ontology for DCN Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DCN Gene

MGI Knock Outs for DCN:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for DCN Gene

Localization for DCN Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCN Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCN gene
Compartment Confidence
extracellular 5
lysosome 5
golgi apparatus 4
plasma membrane 2
cytoskeleton 2
mitochondrion 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005589 collagen type VI trimer IEA --
GO:0005615 extracellular space IDA 20551380
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DCN: view

Pathways & Interactions for DCN Gene

genes like me logo Genes that share pathways with DCN: view

Gene Ontology (GO) - Biological Process for DCN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001822 kidney development IEA --
GO:0001890 placenta development IEA --
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0007519 skeletal muscle tissue development IEA --
GO:0007568 aging IEA --
genes like me logo Genes that share ontologies with DCN: view

No data available for SIGNOR curated interactions for DCN Gene

Drugs & Compounds for DCN Gene

(28) Drugs for DCN Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tris Approved Pharma Target 0

(43) Additional Compounds for DCN Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DCN: view

Transcripts for DCN Gene

Unigene Clusters for DCN Gene

Decorin:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCN Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - - - - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP5: - - - - - - - - - - - - - - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - - - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - -
SP12: - - - - - - - - - - - - - - - - - - - - -
SP13: - - - - - -
SP14: - - - -
SP15: - - - - - - - - - - -
SP16: -
SP17: - -

ExUns: 12d · 12e ^ 13a · 13b ^ 14 ^ 15a · 15b · 15c · 15d ^ 16a · 16b · 16c · 16d · 16e
SP1:
SP2:
SP3:
SP4:
SP5: - - - -
SP6:
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12: - - - - - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DCN Gene

GeneLoc Exon Structure for
DCN
ECgene alternative splicing isoforms for
DCN

Expression for DCN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCN Gene

This gene is overexpressed in Urinary Bladder (8.0) and Nasopharynx (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCN Gene



Protein tissue co-expression partners for DCN Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCN Gene:

DCN

SOURCE GeneReport for Unigene cluster for DCN Gene:

Hs.156316

Evidence on tissue expression from TISSUES for DCN Gene

  • Lung(4.9)
  • Bone(4.8)
  • Eye(4.8)
  • Liver(4.8)
  • Nervous system(4.7)
  • Heart(4.6)
  • Muscle(4.4)
  • Intestine(4.2)
  • Pancreas(4.1)
  • Skin(4)
  • Stomach(3.7)
  • Kidney(3.4)
  • Gall bladder(2.9)
  • Adrenal gland(2.8)
  • Lymph node(2.2)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DCN Gene

Germ Layers:
  • ectoderm
Systems:
  • nervous
Organs:
Head and neck:
  • brain
  • cranial nerve
  • eye
  • head
General:
  • peripheral nervous system
genes like me logo Genes that share expression patterns with DCN: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCN Gene

Orthologs for DCN Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCN 34 35
  • 99.81 (n)
dog
(Canis familiaris)
Mammalia DCN 34 35
  • 90.41 (n)
cow
(Bos Taurus)
Mammalia DCN 34 35
  • 88.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCN 35
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCN 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcn 34 16 35
  • 80.7 (n)
rat
(Rattus norvegicus)
Mammalia Dcn 34
  • 78.91 (n)
chicken
(Gallus gallus)
Aves DCN 34 35
  • 75.35 (n)
lizard
(Anolis carolinensis)
Reptilia DCN 35
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcn 34
  • 70.76 (n)
Str.8982 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24505 34
zebrafish
(Danio rerio)
Actinopterygii dcn 34 35
  • 66.85 (n)
-- 34
Species where no ortholog for DCN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCN Gene

ENSEMBL:
Gene Tree for DCN (if available)
TreeFam:
Gene Tree for DCN (if available)

Paralogs for DCN Gene

Variants for DCN Gene

Sequence variations from dbSNP and Humsavar for DCN Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs397515545 Pathogenic 91,146,191(-) ACCTG(-/G)ACACA reference, utr-variant-3-prime, frameshift-variant
rs587777258 Pathogenic 91,146,176(+) AAGCC(-/T)TTTTG reference, utr-variant-3-prime, frameshift-variant
rs80338741 Pathogenic 91,146,171(-) AGGCT(-/T)CTTAT reference, utr-variant-3-prime, frameshift-variant
rs80338742 Pathogenic 91,146,197(-) CTGCC(-/C)ACCTG reference, utr-variant-3-prime, frameshift-variant
rs141738168 Likely benign 91,178,520(+) ACTTG(C/T)GCAAG reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DCN Gene

Variant ID Type Subtype PubMed ID
dgv210n27 CNV loss 19166990
dgv2784n54 CNV loss 21841781
nsv559751 CNV loss 21841781
nsv559754 CNV loss 21841781
nsv832484 CNV gain+loss 17160897

Variation tolerance for DCN Gene

Residual Variation Intolerance Score: 20.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCN Gene

Human Gene Mutation Database (HGMD)
DCN
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCN Gene

Disorders for DCN Gene

MalaCards: The human disease database

(26) MalaCards diseases for DCN Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
corneal dystrophy, congenital stromal
  • congenital stromal corneal dystrophy
stromal dystrophy
interstitial keratitis
localized scleroderma
  • circumscribed scleroderma
neonatal marfan syndrome
  • neonatal mfs
- elite association - COSMIC cancer census association via MalaCards
Search DCN in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

PGS2_HUMAN
  • Corneal dystrophy, congenital stromal (CSCD) [MIM:610048]: A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent. {ECO:0000269 PubMed:15671264}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DCN

Genetic Association Database (GAD)
DCN
Human Genome Epidemiology (HuGE) Navigator
DCN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCN
genes like me logo Genes that share disorders with DCN: view

No data available for Genatlas for DCN Gene

Publications for DCN Gene

  1. The human decorin gene: intron-exon organization, discovery of two alternatively spliced exons in the 5' untranslated region, and mapping of the gene to chromosome 12q23. (PMID: 8432526) Danielson K.G. … Iozzo R.V. (Genomics 1993) 2 3 4 22 64
  2. The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan. (PMID: 16902402) Wang I.J. … Lin L.L. (Mol. Vis. 2006) 3 22 46 64
  3. GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease. (PMID: 21658281) Aouizerat B.E. … Tseng Z.H. (BMC Cardiovasc Disord 2011) 3 46 64
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  5. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". (PMID: 20628624) Johnatty S.E. … . (PLoS Genet. 2010) 3 46 64

Products for DCN Gene

Sources for DCN Gene

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