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Aliases for DCLRE1A Gene

Aliases for DCLRE1A Gene

  • DNA Cross-Link Repair 1A 2 3
  • SNM1A 3 4 6
  • SNM1 3 4 6
  • SNM1 Homolog A 3 4
  • KIAA0086 4 6
  • DNA Cross-Link Repair 1A (PSO2 Homolog, S. Cerevisiae) 2
  • DNA Cross-Link Repair 1A Protein 3
  • DNA-Crosslink Repair Gene SNM1 3
  • PSO2 Homolog (S. Cerevisiae) 2
  • HSNM1A 4
  • HSNM1 4
  • PSO2 3

External Ids for DCLRE1A Gene

Previous GeneCards Identifiers for DCLRE1A Gene

  • GC10M114501
  • GC10M114828
  • GC10M115725
  • GC10M115259
  • GC10M115584
  • GC10M109221

Summaries for DCLRE1A Gene

Entrez Gene Summary for DCLRE1A Gene

  • This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

GeneCards Summary for DCLRE1A Gene

DCLRE1A (DNA Cross-Link Repair 1A) is a Protein Coding gene. Among its related pathways are Chks in Checkpoint Regulation. GO annotations related to this gene include hydrolase activity. An important paralog of this gene is DCLRE1B.

UniProtKB/Swiss-Prot for DCLRE1A Gene

  • May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.

Gene Wiki entry for DCLRE1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLRE1A Gene

Genomics for DCLRE1A Gene

Regulatory Elements for DCLRE1A Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCLRE1A Gene

Start:
113,834,724 bp from pter
End:
113,854,404 bp from pter
Size:
19,681 bases
Orientation:
Minus strand

Genomic View for DCLRE1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCLRE1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLRE1A Gene

Proteins for DCLRE1A Gene

  • Protein details for DCLRE1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJP8-DCR1A_HUMAN
    Recommended name:
    DNA cross-link repair 1A protein
    Protein Accession:
    Q6PJP8
    Secondary Accessions:
    • D3DRC1
    • Q14701
    • Q6P5Y3
    • Q6PKL4

    Protein attributes for DCLRE1A Gene

    Size:
    1040 amino acids
    Molecular mass:
    116400 Da
    Quaternary structure:
    • Binds constitutively to TP53BP1. Binds CDC27, which is itself a component of the anaphase promoting complex (APC). Binds PIAS1
    SequenceCaution:
    • Sequence=BAA07646.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCLRE1A Gene

neXtProt entry for DCLRE1A Gene

Proteomics data for DCLRE1A Gene at MOPED

Post-translational modifications for DCLRE1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCLRE1A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCLRE1A Gene

Domains for DCLRE1A Gene

Protein Domains for DCLRE1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCLRE1A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PJP8

UniProtKB/Swiss-Prot:

DCR1A_HUMAN :
  • Q6PJP8
Family:
  • Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.
genes like me logo Genes that share domains with DCLRE1A: view

No data available for Gene Families for DCLRE1A Gene

Function for DCLRE1A Gene

Molecular function for DCLRE1A Gene

UniProtKB/Swiss-Prot Function: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.
UniProtKB/Swiss-Prot Induction: During mitosis. The mRNA encoding this protein contains an internal ribosome entry site (IRES) in its 5-UTR. This 5-UTR generally suppresses translation while specifically promoting expression during mitosis, when cap-dependent translation may be impaired.

Gene Ontology (GO) - Molecular Function for DCLRE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035312 5-3 exodeoxyribonuclease activity IDA 22692201
genes like me logo Genes that share ontologies with DCLRE1A: view
genes like me logo Genes that share phenotypes with DCLRE1A: view

Animal Models for DCLRE1A Gene

MGI Knock Outs for DCLRE1A:

Animal Model Products

CRISPR Products

miRNA for DCLRE1A Gene

miRTarBase miRNAs that target DCLRE1A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DCLRE1A Gene

Localization for DCLRE1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCLRE1A Gene

Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11A, RAD50 and NBN) and BRCA1.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCLRE1A Gene COMPARTMENTS Subcellular localization image for DCLRE1A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for DCLRE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with DCLRE1A: view

Pathways for DCLRE1A Gene

SuperPathways for DCLRE1A Gene

Superpath Contained pathways
1 Chks in Checkpoint Regulation
genes like me logo Genes that share pathways with DCLRE1A: view

Pathways by source for DCLRE1A Gene

1 Qiagen pathway for DCLRE1A Gene

Gene Ontology (GO) - Biological Process for DCLRE1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006289 nucleotide-excision repair IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0051301 cell division IEA --
GO:0090305 nucleic acid phosphodiester bond hydrolysis IDA 22692201
genes like me logo Genes that share ontologies with DCLRE1A: view

Transcripts for DCLRE1A Gene

Unigene Clusters for DCLRE1A Gene

DNA cross-link repair 1A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCLRE1A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCLRE1A Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2: -

Relevant External Links for DCLRE1A Gene

GeneLoc Exon Structure for
DCLRE1A
ECgene alternative splicing isoforms for
DCLRE1A

Expression for DCLRE1A Gene

mRNA expression in normal human tissues for DCLRE1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCLRE1A Gene

SOURCE GeneReport for Unigene cluster for DCLRE1A Gene Hs.1560

mRNA Expression by UniProt/SwissProt for DCLRE1A Gene

Q6PJP8-DCR1A_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.
genes like me logo Genes that share expressions with DCLRE1A: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DCLRE1A Gene

Orthologs for DCLRE1A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCLRE1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCLRE1A 35
  • 99.2 (n)
  • 98.85 (a)
DCLRE1A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCLRE1A 35
  • 83.85 (n)
  • 74.28 (a)
DCLRE1A 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCLRE1A 35
  • 82.56 (n)
  • 73.6 (a)
DCLRE1A 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dclre1a 35
  • 73.16 (n)
  • 65.9 (a)
Dclre1a 16
Dclre1a 36
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCLRE1A 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCLRE1A 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dclre1a 35
  • 71.57 (n)
  • 63.34 (a)
chicken
(Gallus gallus)
Aves DCLRE1A 35
  • 60.06 (n)
  • 51.57 (a)
DCLRE1A 36
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCLRE1A 36
  • 38 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.25638 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dclre1a 35
  • 56.94 (n)
  • 53.22 (a)
Str.16944 35
zebrafish
(Danio rerio)
Actinopterygii dclre1a 35
  • 53.03 (n)
  • 48.91 (a)
dclre1a 36
  • 37 (a)
OneToOne
wufc49f05 35
fruit fly
(Drosophila melanogaster)
Insecta Snm1 37
  • 37 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PSO2 36
  • 21 (a)
OneToMany
PSO2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons SNM1 35
  • 52.55 (n)
  • 48.47 (a)
rice
(Oryza sativa)
Liliopsida Os04g0401800 35
  • 48.48 (n)
  • 44.09 (a)
Species with no ortholog for DCLRE1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCLRE1A Gene

ENSEMBL:
Gene Tree for DCLRE1A (if available)
TreeFam:
Gene Tree for DCLRE1A (if available)

Paralogs for DCLRE1A Gene

Paralogs for DCLRE1A Gene

genes like me logo Genes that share paralogs with DCLRE1A: view

Variants for DCLRE1A Gene

Sequence variations from dbSNP and Humsavar for DCLRE1A Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs10567 -- 113,834,966(-) TCAAG(A/G)ATAAC utr-variant-3-prime
rs1126734 -- 113,848,996(-) CCATT(C/G)TATAA reference, missense
rs3179765 -- 113,834,725(-) aattt(A/G)CTCTG utr-variant-3-prime
rs3750898 - 113,850,156(-) AACCG(C/G)ATGAT missense, reference
rs4463806 -- 113,838,234(+) CCTAG(C/T)TAATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCLRE1A Gene

Variant ID Type Subtype PubMed ID
nsv7211 OTHER Inversion 18451855
nsv831995 CNV Gain+Loss 17160897
nsv896016 CNV Loss 21882294
nsv507578 CNV Insertion 20534489

Relevant External Links for DCLRE1A Gene

HapMap Linkage Disequilibrium report
DCLRE1A
Human Gene Mutation Database (HGMD)
DCLRE1A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCLRE1A Gene

Disorders for DCLRE1A Gene

(1) University of Copenhagen DISEASES for DCLRE1A Gene

Relevant External Links for DCLRE1A

Genetic Association Database (GAD)
DCLRE1A
Human Genome Epidemiology (HuGE) Navigator
DCLRE1A
genes like me logo Genes that share disorders with DCLRE1A: view

No data available for UniProtKB/Swiss-Prot for DCLRE1A Gene

Publications for DCLRE1A Gene

  1. Genomic organization of a potential human DNA-crosslink repair gene, KIAA0086. (PMID: 9806498) Demuth I. … Digweed M. (Mutat. Res. 1998) 2 3 23
  2. Disruption of mouse SNM1 causes increased sensitivity to the DNA interstrand cross-linking agent mitomycin C. (PMID: 10848582) Dronkert M.L.G. … Kanaar R. (Mol. Cell. Biol. 2000) 3 4 23
  3. hSnm1 colocalizes and physically associates with 53BP1 before and after DNA damage. (PMID: 12446782) Richie C.T. … Legerski R.J. (Mol. Cell. Biol. 2002) 3 4 23
  4. The hSNM1 protein is a DNA 5'-exonuclease. (PMID: 17804464) Hejna J. … Moses R. (Nucleic Acids Res. 2007) 2 3 23
  5. Mammalian SNM1 is required for genome stability. (PMID: 18180189) Hemphill A.W. … Moses R.E. (Mol. Genet. Metab. 2008) 3 23

Products for DCLRE1A Gene

  • antibodies-online peptides for DCLRE1A
  • antibodies-online antibodies for DCLRE1A
  • antibodies-online kits for DCLRE1A

Sources for DCLRE1A Gene

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