Aliases for DCLRE1A Gene
External Ids for DCLRE1A Gene
Previous GeneCards Identifiers for DCLRE1A Gene
This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
GeneCards Summary for DCLRE1A Gene
DCLRE1A (DNA Cross-Link Repair 1A) is a Protein Coding gene. Diseases associated with DCLRE1A include intestinal volvulus and fanconi anemia, complementation group a. Among its related pathways are Chks in Checkpoint Regulation and DNA Double-Strand Break Repair. GO annotations related to this gene include 5-3 exodeoxyribonuclease activity. An important paralog of this gene is DCLRE1B.
UniProtKB/Swiss-Prot for DCLRE1A Gene
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.