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DCLK3 Gene

protein-coding   GIFtS: 47
GCID: GC03M036731

Doublecortin-Like Kinase 3

(Previous name: doublecortin and CaM kinase-like 3)
(Previous symbol: DCAMKL3)
  Search for DCLK3
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Doublecortin-Like Kinase 31 2 3     CLR2 5
DCAMKL31 2 3     DCK32 5
Doublecortin And CaM Kinase-Like 31 2     CLICK-I,II-related2
Doublecortin Domain-Containing Protein 3C2 3     Serine/Threonine-Protein Kinase DCLK32
Doublecortin-Like And CAM Kinase-Like 32 3     KIAA17653
DCDC3C2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 190051   Entrez Gene: 854432   Ensembl: ENSG000001636737   OMIM: 6131675   UniProtKB: Q9C0983   

Export aliases for DCLK3 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DCLK3 Gene:
DCLK3 (doublecortin-like kinase 3) is a protein-coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is PNCK.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCLK3 gene promoter:
         GR   Elk-1   AML1a   GR-beta   Pax-2   Pax-2a   Evi-1   Pax-2b   GR-alpha   Ik-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DCLK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCLK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p22.3

DCLK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCLK3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M036731:  view genomic region     (about GC identifiers)

Start:
36,753,913 bp from pter      End:
36,781,352 bp from pter
Size:
27,440 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCLK3_HUMAN, Q9C098 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase DCLK3  
Size: 648 amino acids; 73814 Da

Explore the universe of human proteins at neXtProt for DCLK3: NX_Q9C098

Explore proteomics data for DCLK3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DCLK3 (Q9C098) (see all 8)
     GVILYIL  LADFGLA  VHRDLKP  QVLQHPW 


    See DCLK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_208382.1  
    ENSEMBL proteins: 
     ENSP00000394484  

    DCLK3 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DCLK3

     
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    Cloud-Clone Corp. ELISAs for DCLK3
    Cloud-Clone Corp. CLIAs for DCLK3
    Search eBioscience for ELISAs for DCLK3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: doublecortin-like kinase 3
    DCAMKL family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9C098

    ProtoNet protein and cluster: Q9C098

    UniProtKB/Swiss-Prot: DCLK3_HUMAN, Q9C098
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with DCLK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCLK3_HUMAN, Q9C098
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    Find genes that share ontologies with DCLK3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DCLK3:
     Increased cell death HMECs cel  Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCLK3
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    Selected qRT-PCR Assays for microRNAs that regulate DCLK3 (see all 23):
    hsa-miR-623 hsa-miR-1226 hsa-miR-300 hsa-miR-3660 hsa-miR-29a hsa-miR-29c hsa-miR-216b hsa-miR-3162-5p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCLK3_HUMAN, Q9C098: Cytoplasm (By similarity). Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    extracellular2
    nucleus2
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DCLK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCLK3
    Interactions:

        Search GeneGlobe Interaction Network for DCLK3

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----

    Find genes that share ontologies with DCLK3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCLK3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCLK3 gene: 
    NM_033403.1  

    Unigene Cluster for DCLK3:

    Doublecortin-like kinase 3
    Hs.631907  [show with all ESTs]
    Unigene Representative Sequence: NM_033403
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000416516(uc003cgi.2) ENST00000498047
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DCLK3 (see all 23):
    hsa-miR-623 hsa-miR-1226 hsa-miR-300 hsa-miR-3660 hsa-miR-29a hsa-miR-29c hsa-miR-216b hsa-miR-3162-5p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DCLK3
      QuantiFast Probe-based Assays in human, mouse, rat DCLK3

    Additional mRNA sequence: 

    AB051552.1 AK122988.1 

    1 DOTS entry:

    DT.40204529 

    1 AceView cDNA sequence:

    BG292531 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCLK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DCLK3 Expression
    About this image


    DCLK3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)
             Blimp1- mVenus and stella-ECFP genetically modified stem cells
     
     Bone (Muscoskeletal System)
             Zeugopod Growth Plate
    DCLK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCLK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631907
        Custom PCR Arrays for DCLK3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCLK3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCLK3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dclk31 , 5 doublecortin-like kinase 31, 5 78.1(n)1
    75.57(a)1
      9 (61.33 cM)5
    2450381  NM_172928.51  NP_766516.21 
     1114390815 
    chicken
    (Gallus gallus)
    Aves DCLK31 doublecortin-like kinase 3 62.11(n)
    55.79(a)
      776499  XM_001236016.3  XP_001236017.3 
    lizard
    (Anolis carolinensis)
    Reptilia DCLK36
    doublecortin-like kinase 3
    50(a)
    1 ↔ 1
    6(43423759-43429967)
    zebrafish
    (Danio rerio)
    Actinopterygii dclk36
    doublecortin-like kinase 3
    36(a)
    1 ↔ 1
    19(44541645-44548860) ENSDARG00000078997
    worm
    (Caenorhabditis elegans)
    Secernentea F32D8.11 F32D8.1 49.68(n)
    42.02(a)
      185203  NM_073369.3  NP_505770.3 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CMK16
    CMK26
    Calmodulin-dependent protein kinase; may play a ro...
    Calmodulin-dependent protein kinase; may play a ro...
    26(a)
    25(a)
    many ↔ many
    many ↔ many
    VI(172537-173877) YFR014C
    XV(294777-296120) YOL016C
    rice
    (Oryza sativa)
    Liliopsida AK105102.12   -- 76.27(n)    AK105102.1 


    ENSEMBL Gene Tree for DCLK3 (if available)
    TreeFam Gene Tree for DCLK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCLK3 gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  DCLK12  
    PSKH12  CAMK42  CAMK2D2  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    Selected SIMAP similar genes for DCLK3 using alignment to 1 protein entry:     DCLK3_HUMAN(see all similar genes):
    DCLK1    RPS6KA1    DCLK2    MGC45428    CAMK1G    CAMK1
    KIN27    RPS6KA3    CAMK2G    CAMK1D    CAMK2A    CAMK4
    CAMK2D    PRKACB    DAPK3    MARK4    PNCK    PRKAA1

    Find genes that share paralogs with DCLK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCLK3 (see all 616)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0404474
    A lung large cell carcinoma sample4--see VAR_0404472 S N mis40--------
    VAR_0404484
    A lung squamous cell carcinoma sample4--see VAR_0404482 R C mis40--------
    VAR_0404454
    A breast infiltrating ductal carcinoma sample4--see VAR_0404452 P L mis40--------
    VAR_0404464
    A colorectal adenocarcinoma sample4--see VAR_0404462 E K mis40--------
    VAR_0404494
    A renal clear cell carcinoma sample4--see VAR_0404492 G R mis40--------
    VAR_0404504
    A colorectal adenocarcinoma sample4--see VAR_0404502 V A mis40--------
    rs722578161,2
    C--36713680(+) GCGTG-/CACA  
            
    CACAC
    1 -- int10--------
    rs795924911,2
    --36753599(+) GAGGTA/GTCAAG 1 -- ds50010--------
    rs1130807571,2
    F--36753644(+) CCATTC/TCCTGA 1 -- ds50012Minor allele frequency- T:0.03CSA WA 120
    rs738244601,2
    C,F--36753683(+) TTGGAG/AGTGAT 1 -- ds50012Minor allele frequency- A:0.09WA 120

    HapMap Linkage Disequilibrium report for DCLK3 (36753913 - 36781352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DCLK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2665523CNV Deletion23128226
    nsv834660CNV Loss17160897
    nsv876703CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613167    OMIM disorders: --


    Find genes that share disorders with DCLK3           About GenesLikeMe

    Genetic Association Database (GAD): DCLK3
    Human Genome Epidemiology (HuGE) Navigator: DCLK3 (1 document)

    Export disorders for DCLK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCLK3 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with DCLK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The evolving doublecortin (DCX) superfamily. (PubMed id 16869982)1, 3 Reiner O.... Bergmann S. (BMC Genomics 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    6. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    7. The doublecortin gene family and disorders of neuronal structure. (PubMed id 20236041)1 Dijkmans T.F.... Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010)
    8. Patterns of somatic mutation in human cancer genomes. (PubMed id 17344846)2 Greenman C.... Stratton M.R. (Nature 2007)
    9. A diagnostic marker set for invasion, proliferation, and aggressiveness of prolactin pituitary tumors. (PubMed id 17914117)1 Wierinckx A....Trouillas J. (Endocr. Relat. Cancer 2007)
    10. Molecular identification and characterization of a family of kinases with homology to Ca2+/calmodulin-dependent protein kinases I/IV. (PubMed id 16684769)1 Ohmae S....Bito H. (J. Biol. Chem. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 85443 HGNC: 19005 AceView: KIAA1765.1 Ensembl:ENSG00000163673 euGenes: HUgn85443
    ECgene: DCLK3 H-InvDB: DCLK3

    (According to HUGE)
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    HUGE: KIAA1765

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCLK3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCLK3 gene:
    Search GeneIP for patents involving DCLK3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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