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Aliases for DCLK3 Gene

Aliases for DCLK3 Gene

  • Doublecortin Like Kinase 3 2 3 5
  • Doublecortin-Like Kinase 3 2 3 4
  • Doublecortin Domain-Containing Protein 3C 3 4
  • Doublecortin-Like And CAM Kinase-Like 3 3 4
  • Doublecortin And CaM Kinase-Like 3 2 3
  • EC 4 63
  • DCAMKL3 3 4
  • DCDC3C 3 4
  • CLICK-I,II-Related 3
  • EC 2.7.11 63
  • KIAA1765 4
  • DCK3 3
  • CLR 3

External Ids for DCLK3 Gene

Previous HGNC Symbols for DCLK3 Gene


Summaries for DCLK3 Gene

GeneCards Summary for DCLK3 Gene

DCLK3 (Doublecortin Like Kinase 3) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK33.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK3 Gene

Genomics for DCLK3 Gene

Regulatory Elements for DCLK3 Gene

Enhancers for DCLK3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCLK3 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCLK3 Gene

36,712,422 bp from pter
36,764,204 bp from pter
51,783 bases
Minus strand

Genomic View for DCLK3 Gene

Genes around DCLK3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCLK3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCLK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK3 Gene

Proteins for DCLK3 Gene

  • Protein details for DCLK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein kinase DCLK3
    Protein Accession:

    Protein attributes for DCLK3 Gene

    648 amino acids
    Molecular mass:
    73814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCLK3 Gene

Proteomics data for DCLK3 Gene at MOPED

Selected DME Specific Peptides for DCLK3 Gene

Post-translational modifications for DCLK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCLK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DCLK3

Domains & Families for DCLK3 Gene

Gene Families for DCLK3 Gene

Suggested Antigen Peptide Sequences for DCLK3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with DCLK3: view

Function for DCLK3 Gene

Molecular function for DCLK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.

Enzyme Numbers (IUBMB) for DCLK3 Gene

genes like me logo Genes that share phenotypes with DCLK3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DCLK3

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCLK3 Gene

Localization for DCLK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCLK3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Jensen Localization Image for DCLK3 Gene COMPARTMENTS Subcellular localization image for DCLK3 gene
Compartment Confidence
nucleus 4
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DCLK3 Gene

Pathways & Interactions for DCLK3 Gene

SuperPathways for DCLK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCLK3 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCLK3 Gene

Drugs & Compounds for DCLK3 Gene

No Compound Related Data Available

Transcripts for DCLK3 Gene

mRNA/cDNA for DCLK3 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCLK3 Gene

Doublecortin-like kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK3 Gene

No ASD Table

Relevant External Links for DCLK3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCLK3 Gene

mRNA expression in normal human tissues for DCLK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCLK3 Gene

This gene is overexpressed in Nerve - Tibial (x18.6), Brain - Nucleus accumbens (basal ganglia) (x7.9), Brain - Putamen (basal ganglia) (x5.0), and Brain - Caudate (basal ganglia) (x4.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCLK3 Gene

SOURCE GeneReport for Unigene cluster for DCLK3 Gene Hs.631907

genes like me logo Genes that share expression patterns with DCLK3: view

Protein tissue co-expression partners for DCLK3 Gene

Primer Products

No data available for Protein differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCLK3 Gene

Orthologs for DCLK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCLK3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCLK3 35
  • 80.65 (n)
  • 78.79 (a)
DCLK3 36
  • 79 (a)
(Canis familiaris)
Mammalia DCLK3 35
  • 78.9 (n)
  • 76.69 (a)
DCLK3 36
  • 74 (a)
(Mus musculus)
Mammalia Dclk3 35
  • 78.1 (n)
  • 75.57 (a)
Dclk3 16
Dclk3 36
  • 59 (a)
(Pan troglodytes)
Mammalia DCLK3 35
  • 99.64 (n)
  • 99.54 (a)
DCLK3 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dclk3 35
  • 79.42 (n)
  • 77.95 (a)
(Monodelphis domestica)
Mammalia DCLK3 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia DCLK3 36
  • 47 (a)
(Gallus gallus)
Aves DCLK3 35
  • 62.11 (n)
  • 55.79 (a)
DCLK3 36
  • 52 (a)
(Anolis carolinensis)
Reptilia DCLK3 36
  • 50 (a)
(Danio rerio)
Actinopterygii dclk3 36
  • 36 (a)
(Caenorhabditis elegans)
Secernentea F32D8.1 35
  • 49.68 (n)
  • 42.02 (a)
F32D8.1 36
  • 35 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 36
  • 26 (a)
CMK2 36
  • 25 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6667 35
Species with no ortholog for DCLK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DCLK3 Gene

Gene Tree for DCLK3 (if available)
Gene Tree for DCLK3 (if available)

Paralogs for DCLK3 Gene

Paralogs for DCLK3 Gene

genes like me logo Genes that share paralogs with DCLK3: view

Variants for DCLK3 Gene

Sequence variations from dbSNP and Humsavar for DCLK3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs56070233 - 36,738,589(+) GGGCC(C/T)GGGCT reference, missense
VAR_040445 A breast infiltrating ductal carcinoma sample
VAR_040446 A colorectal adenocarcinoma sample
VAR_040447 A lung large cell carcinoma sample
VAR_040448 A lung squamous cell carcinoma sample

Structural Variations from Database of Genomic Variants (DGV) for DCLK3 Gene

Variant ID Type Subtype PubMed ID
nsv876703 CNV Loss 21882294
nsv834660 CNV Loss 17160897
esv2665523 CNV Deletion 23128226

Variation tolerance for DCLK3 Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.97; 36.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DCLK3 Gene

Disorders for DCLK3 Gene

Relevant External Links for DCLK3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCLK3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCLK3 Gene

Publications for DCLK3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 2 3
  3. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3
  4. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for DCLK3 Gene

Sources for DCLK3 Gene