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Aliases for DCLK3 Gene

Aliases for DCLK3 Gene

  • Doublecortin-Like Kinase 3 2 3 4
  • Doublecortin Domain-Containing Protein 3C 3 4
  • Doublecortin-Like And CAM Kinase-Like 3 3 4
  • Doublecortin And CaM Kinase-Like 3 2 3
  • EC 2.7.11.1 4 64
  • DCAMKL3 3 4
  • DCDC3C 3 4
  • DCK3 3 6
  • CLR 3 6
  • Serine/Threonine-Protein Kinase DCLK3 3
  • CLICK-I,II-Related 3
  • EC 2.7.11 64
  • KIAA1765 4

External Ids for DCLK3 Gene

Previous Symbols for DCLK3 Gene

  • DCAMKL3

Summaries for DCLK3 Gene

GeneCards Summary for DCLK3 Gene

DCLK3 (Doublecortin-Like Kinase 3) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is DCX.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK3 Gene

Genomics for DCLK3 Gene

Genomic Location for DCLK3 Gene

Start:
36,712,422 bp from pter
End:
36,739,861 bp from pter
Size:
27,440 bases
Orientation:
Minus strand

Genomic View for DCLK3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCLK3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK3 Gene

Regulatory Elements for DCLK3 Gene

Proteins for DCLK3 Gene

  • Protein details for DCLK3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C098-DCLK3_HUMAN
    Recommended name:
    Serine/threonine-protein kinase DCLK3
    Protein Accession:
    Q9C098
    Secondary Accessions:

    Protein attributes for DCLK3 Gene

    Size:
    648 amino acids
    Molecular mass:
    73814 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCLK3 Gene

Proteomics data for DCLK3 Gene at MOPED

Selected DME Specific Peptides for DCLK3 Gene

Post-translational modifications for DCLK3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCLK3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for DCLK3 Gene

Gene Families for DCLK3 Gene

UniProtKB/Swiss-Prot:

DCLK3_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • Q9C098
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.:
    • Q9C098
genes like me logo Genes that share domains with DCLK3: view

Function for DCLK3 Gene

Molecular function for DCLK3 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein

Enzyme Numbers (IUBMB) for DCLK3 Gene

Gene Ontology (GO) - Molecular Function for DCLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with DCLK3: view

Phenotypes for DCLK3 Gene

GenomeRNAi human phenotypes for DCLK3:
genes like me logo Genes that share phenotypes with DCLK3: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DCLK3 Gene

Localization for DCLK3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCLK3 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCLK3 Gene COMPARTMENTS Subcellular localization image for DCLK3 gene
Compartment Confidence
cytosol 3
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DCLK3: view

Pathways for DCLK3 Gene

SuperPathways for DCLK3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCLK3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with DCLK3: view

No data available for Pathways by source for DCLK3 Gene

Transcripts for DCLK3 Gene

mRNA/cDNA for DCLK3 Gene

(4) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCLK3 Gene

Doublecortin-like kinase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK3 Gene

No ASD Table

Relevant External Links for DCLK3 Gene

GeneLoc Exon Structure for
DCLK3
ECgene alternative splicing isoforms for
DCLK3

Expression for DCLK3 Gene

mRNA expression in normal human tissues for DCLK3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCLK3 Gene

This gene is overexpressed in Nerve - Tibial (18.6), Brain - Nucleus accumbens (basal ganglia) (7.9), Brain - Putamen (basal ganglia) (5.0), and Brain - Caudate (basal ganglia) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DCLK3 Gene

SOURCE GeneReport for Unigene cluster for DCLK3 Gene Hs.631907

genes like me logo Genes that share expressions with DCLK3: view

Orthologs for DCLK3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DCLK3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCLK3 36
  • 99.64 (n)
  • 99.54 (a)
DCLK3 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCLK3 36
  • 80.65 (n)
  • 78.79 (a)
DCLK3 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCLK3 36
  • 78.9 (n)
  • 76.69 (a)
DCLK3 37
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dclk3 36
  • 78.1 (n)
  • 75.57 (a)
Dclk3 16
Dclk3 37
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCLK3 37
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCLK3 37
  • 47 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dclk3 36
  • 79.42 (n)
  • 77.95 (a)
chicken
(Gallus gallus)
Aves DCLK3 36
  • 62.11 (n)
  • 55.79 (a)
DCLK3 37
  • 52 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCLK3 37
  • 50 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dclk3 37
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F32D8.1 36
  • 49.68 (n)
  • 42.02 (a)
F32D8.1 37
  • 35 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 37
  • 26 (a)
ManyToMany
CMK2 37
  • 25 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6667 36
Species with no ortholog for DCLK3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DCLK3 Gene

ENSEMBL:
Gene Tree for DCLK3 (if available)
TreeFam:
Gene Tree for DCLK3 (if available)

Paralogs for DCLK3 Gene

genes like me logo Genes that share paralogs with DCLK3: view

Variants for DCLK3 Gene

Sequence variations from dbSNP and Humsavar for DCLK3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs885461 -- 36,718,356(+) GGACT(C/G)TACAC intron-variant
rs906477 -- 36,718,887(+) aaaat(G/T)tttat intron-variant
rs1507873 -- 36,729,914(+) gctca(A/G)gcctg intron-variant
rs1507874 -- 36,730,076(+) tggga(A/G)gctaa intron-variant
rs1507875 -- 36,730,082(+) gctaa(A/G)gtggg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCLK3 Gene

Variant ID Type Subtype PubMed ID
nsv876703 CNV Loss 21882294
nsv834660 CNV Loss 17160897
esv2665523 CNV Deletion 23128226

Relevant External Links for DCLK3 Gene

HapMap Linkage Disequilibrium report
DCLK3

Disorders for DCLK3 Gene

Relevant External Links for DCLK3

Genetic Association Database (GAD)
DCLK3
Human Genome Epidemiology (HuGE) Navigator
DCLK3
genes like me logo Genes that share disorders with DCLK3: view

No data available for UniProtKB/Swiss-Prot for DCLK3 Gene

Publications for DCLK3 Gene

  1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for DCLK3 Gene

Sources for DCLK3 Gene

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