Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCLK2 Gene

Aliases for DCLK2 Gene

  • Doublecortin-Like Kinase 2 2 3 4
  • DCK2 3 4 6
  • CL2 3 4 6
  • Doublecortin Domain-Containing Protein 3B 3 4
  • Doublecortin-Like And CAM Kinase-Like 2 3 4
  • Doublecortin And CaM Kinase-Like 2 2 3
  • CaMK-Like CREB Regulatory Kinase 2 3 4
  • EC 2.7.11.1 4 64
  • CLICK-II 3 4
  • DCAMKL2 3 4
  • CLICK2 3 4
  • DCDC3B 3 4
  • CLIK2 3 6
  • Serine/Threonine-Protein Kinase DCLK2 3
  • EC 2.7.11 64
  • DCDC3 3

External Ids for DCLK2 Gene

Previous Symbols for DCLK2 Gene

  • DCAMKL2

Summaries for DCLK2 Gene

Entrez Gene Summary for DCLK2 Gene

  • This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCLK2 Gene

DCLK2 (Doublecortin-Like Kinase 2) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for DCLK2 Gene

  • Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK2 Gene

Genomics for DCLK2 Gene

Genomic Location for DCLK2 Gene

Start:
150,078,274 bp from pter
End:
150,257,457 bp from pter
Size:
179,184 bases
Orientation:
Plus strand

Genomic View for DCLK2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK2 Gene

Regulatory Elements for DCLK2 Gene

Proteins for DCLK2 Gene

  • Protein details for DCLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N568-DCLK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase DCLK2
    Protein Accession:
    Q8N568
    Secondary Accessions:
    • C9J5Q9
    • Q59GC8
    • Q8N399

    Protein attributes for DCLK2 Gene

    Size:
    766 amino acids
    Molecular mass:
    83606 Da
    Quaternary structure:
    • Binds to and stabilizes microtubules. Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin.
    SequenceCaution:
    • Sequence=BAD92418.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCLK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCLK2 Gene

Proteomics data for DCLK2 Gene at MOPED

Post-translational modifications for DCLK2 Gene

Other Protein References for DCLK2 Gene

Domains for DCLK2 Gene

Gene Families for DCLK2 Gene

UniProtKB/Swiss-Prot:

DCLK2_HUMAN
Domain:
  • The doublecortin domains are involved in the colocalization with microtubules.:
    • Q8N568
  • Contains 2 doublecortin domains.:
    • Q8N568
  • Contains 1 protein kinase domain.:
    • Q8N568
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.:
    • Q8N568
genes like me logo Genes that share domains with DCLK2: view

Function for DCLK2 Gene

Molecular function for DCLK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).

Enzyme Numbers (IUBMB) for DCLK2 Gene

Gene Ontology (GO) - Molecular Function for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005524 ATP binding IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups --
genes like me logo Genes that share ontologies with DCLK2: view
genes like me logo Genes that share phenotypes with DCLK2: view

Animal Models for DCLK2 Gene

MGI Knock Outs for DCLK2:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for DCLK2 Gene

Localization for DCLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCLK2 Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCLK2 Gene COMPARTMENTS Subcellular localization image for DCLK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with DCLK2: view

Pathways for DCLK2 Gene

SuperPathways for DCLK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCLK2: view

No data available for Pathways by source for DCLK2 Gene

Compounds for DCLK2 Gene

(2) HMDB Compounds for DCLK2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with DCLK2: view

Transcripts for DCLK2 Gene

Unigene Clusters for DCLK2 Gene

Doublecortin-like kinase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -

Relevant External Links for DCLK2 Gene

GeneLoc Exon Structure for
DCLK2
ECgene alternative splicing isoforms for
DCLK2

Expression for DCLK2 Gene

mRNA expression in normal human tissues for DCLK2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCLK2 Gene

SOURCE GeneReport for Unigene cluster for DCLK2 Gene Hs.591683

mRNA Expression by UniProt/SwissProt for DCLK2 Gene

Q8N568-DCLK2_HUMAN
Tissue specificity: Expressed in the brain, heart and eyes.
genes like me logo Genes that share expressions with DCLK2: view

Orthologs for DCLK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCLK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCLK2 36
  • 99.7 (n)
  • 99.49 (a)
DCLK2 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCLK2 36
  • 90.97 (n)
  • 97.3 (a)
DCLK2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCLK2 36
  • 93.26 (n)
  • 97.6 (a)
DCLK2 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dclk2 36
  • 89.02 (n)
  • 94.29 (a)
Dclk2 16
Dclk2 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCLK2 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCLK2 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dclk2 36
  • 88.47 (n)
  • 94.36 (a)
chicken
(Gallus gallus)
Aves DCLK2 36
  • 81.24 (n)
  • 89.1 (a)
DCLK2 37
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCLK2 37
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487296 36
  • 75.48 (n)
  • 83.82 (a)
zebrafish
(Danio rerio)
Actinopterygii BX005047.1 37
  • 78 (a)
OneToMany
dclk2 36
  • 71.21 (n)
  • 77.17 (a)
dclk2 37
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009034 36
  • 53.71 (n)
  • 49.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17528 36
  • 51.39 (n)
  • 47.68 (a)
CG17528 37
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zyg-8 37
  • 31 (a)
OneToMany
Species with no ortholog for DCLK2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCLK2 Gene

ENSEMBL:
Gene Tree for DCLK2 (if available)
TreeFam:
Gene Tree for DCLK2 (if available)

Paralogs for DCLK2 Gene

genes like me logo Genes that share paralogs with DCLK2: view

Variants for DCLK2 Gene

Sequence variations from dbSNP and Humsavar for DCLK2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs727426 -- 150,221,063(-) ATTGA(C/G)AGAAA intron-variant
rs922121 -- 150,234,118(+) CACCT(C/G)CATTG intron-variant
rs922122 -- 150,234,441(+) CTGAC(C/T)ACTGA intron-variant
rs966120 -- 150,226,088(+) GGAAC(C/T)CCTAA intron-variant
rs996958 -- 150,226,931(+) GCCAC(C/G)TATGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCLK2 Gene

Variant ID Type Subtype PubMed ID
nsv830111 CNV Gain 17160897
esv2673603 CNV Deletion 23128226
nsv292617 CNV Loss 16902084
nsv880256 CNV Gain 21882294
nsv509018 CNV Insertion 20534489
nsv261 CNV Insertion 15895083
nsv4546 CNV Insertion 18451855
nsv507204 CNV Insertion 20534489
nsv880257 CNV Gain 21882294
esv1001185 CNV Insertion 20482838
nsv880258 CNV Gain 21882294

Relevant External Links for DCLK2 Gene

HapMap Linkage Disequilibrium report
DCLK2

Disorders for DCLK2 Gene

(1) University of Copenhagen DISEASES for DCLK2 Gene

Relevant External Links for DCLK2

Genetic Association Database (GAD)
DCLK2
genes like me logo Genes that share disorders with DCLK2: view

No data available for UniProtKB/Swiss-Prot for DCLK2 Gene

Publications for DCLK2 Gene

  1. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. (PMID: 15611072) Edelman A.M. … Sigurdson W. (J. Biol. Chem. 2005) 3 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 3 4
  4. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. (PMID: 18075264) Tuy F.P.D. … Francis F. (Dev. Neurosci. 2008) 3 4
  5. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3 4

Products for DCLK2 Gene

  • Addgene plasmids for DCLK2

Sources for DCLK2 Gene

Back to Top

Content