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DCLK2 Gene

protein-coding   GIFtS: 54
GCID: GC04P150999

Doublecortin-Like Kinase 2

(Previous name: doublecortin and CaM kinase-like 2)
(Previous symbol: DCAMKL2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Doublecortin-Like Kinase 21 2 3     CLICK22 3
DCAMKL21 2 3     DCDC3B2 3
CL22 3 5     CaMK-Like CREB Regulatory Kinase 22 3
DCK22 3 5     EC 2.7.11.13 8
Doublecortin And CaM Kinase-Like 21 2     CLIK22 5
Doublecortin Domain-Containing Protein 3B2 3     DCDC32
Doublecortin-Like And CAM Kinase-Like 22 3     Serine/Threonine-Protein Kinase DCLK22
CLICK-II2 3     EC 2.7.118

External Ids:    HGNC: 190021   Entrez Gene: 1666142   Ensembl: ENSG000001703907   OMIM: 6131665   UniProtKB: Q8N5683   

Export aliases for DCLK2 gene to outside databases

Previous GC identifers: GC04P151219 GC04P146723


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCLK2 Gene:
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by
this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule
polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to
Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the
protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing
activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX
gene, another family member, and this gene share function in the establishment of hippocampal organization and
that their absence results in a severe epileptic phenotype and lethality, as described in human patients with
lissencephaly. Multiple alternatively spliced transcript variants have been identified. (provided by RefSeq, Sep
2010)

GeneCards Summary for DCLK2 Gene:
DCLK2 (doublecortin-like kinase 2) is a protein-coding gene. Diseases associated with DCLK2 include lissencephaly, and quadriplegia. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is PNCK.

UniProtKB/Swiss-Prot: DCLK2_HUMAN, Q8N568
Function: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members
of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by
phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NT_016354.20  NC_018915.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCLK2 gene promoter:
         Bach2   STAT1beta   Pax-2   Pax-2a   LCR-F1   C/EBPalpha   AREB6   HEN1   IRF-2   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCLK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q31.3   Ensembl cytogenetic band:  4q31.23   HGNC cytogenetic band: 4q31.3

DCLK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCLK2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P150999:  view genomic region     (about GC identifiers)

Start:
150,999,426 bp from pter      End:
151,178,609 bp from pter
Size:
179,184 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCLK2_HUMAN, Q8N568 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase DCLK2  
Size: 766 amino acids; 83606 Da
Subunit: Binds to and stabilizes microtubules (By similarity). Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2,
MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin (By similarity)
Developmental stage: Expressed in fetal brain, and, to a lower extent, in fetal kidney
Sequence caution: Sequence=BAD92418.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9J5Q9 Q59GC8 Q8N399
Alternative splicing: 3 isoforms:  Q8N568-1   Q8N568-2   Q8N568-3   (By homology to mouse isoform 2)

Explore the universe of human proteins at neXtProt for DCLK2: NX_Q8N568

Explore proteomics data for DCLK2 at MOPED

Post-translational modifications: 

  • Autophosphorylated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DCLK2 (Q8N568) (see all 7)
     GNFAVVK  LGDFGLA  HRDIKPEN  GVITYILL 


    See DCLK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001035350.2  NP_001035351.4  

    ENSEMBL proteins: 
     ENSP00000296550   ENSP00000401916   ENSP00000427235   ENSP00000303887  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: doublecortin-like kinase 2
    DCAMKL family

    Selected InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q8N568

    ProtoNet protein and cluster: Q8N568

    1 Blocks protein domain: IPB003533 Doublecortin

    UniProtKB/Swiss-Prot: DCLK2_HUMAN, Q8N568
    Domain: The doublecortin domains are involved in the colocalization with microtubules (By similarity)
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 2 doublecortin domains
    Similarity: Contains 1 protein kinase domain


    DCLK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCLK2_HUMAN, Q8N568
    Function: Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members
    of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by
    phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By
    similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005524ATP binding IEA--
    GO:0016772transferase activity, transferring phosphorus-containing groups ----
         
    DCLK2 for ontologies           About GeneDecksing


    Phenotypes:
         7 GenomeRNAi human phenotypes for DCLK2:
     Decreased focal adhesion (FA)   Decreased influenza A H1N1 (A/  Decreased influenza A/WSN/33 r  Decreased substrate adherent c 
     Increased cilium length after   Synthetic lethal with Ras  Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dclk2):
     behavior/neurological  mortality/aging  nervous system  no phenotypic analysis 

    DCLK2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dclk2tm1.2Jgg for DCLK2

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    hsa-miR-3194-5p hsa-miR-137 hsa-miR-657 hsa-miR-3614-3p hsa-miR-25 hsa-miR-944 hsa-miR-520a-5p hsa-miR-548a-3p
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCLK2_HUMAN, Q8N568: Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--

    DCLK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCLK2
    Interactions:

        Search GeneGlobe Interaction Network for DCLK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for DCLK2 (Q8N5683 ENSP000002965504) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583I2D: score=1 
    KIAA1432ENSP000004022404STRING: ENSP00000402240
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL2ENSP000000053404STRING: ENSP00000005340
    DVL3ENSP000003160544STRING: ENSP00000316054
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation ----
    GO:0035556intracellular signal transduction IEA--

    DCLK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCLK2

    2 HMDB Compounds for DCLK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCLK2 gene (3 alternative transcripts): 
    NM_001040260.3  NM_001040261.4  NM_152619.1  

    Unigene Cluster for DCLK2:

    Doublecortin-like kinase 2
    Hs.591683  [show with all ESTs]
    Unigene Representative Sequence: NR_036614
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296550(uc003ilo.4 uc003ilp.4 uc003ilm.4 uc003iln.4)
    ENST00000411937 ENST00000506325 ENST00000302176 ENST00000507694
    miRNA
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    hsa-miR-3194-5p hsa-miR-137 hsa-miR-657 hsa-miR-3614-3p hsa-miR-25 hsa-miR-944 hsa-miR-520a-5p hsa-miR-548a-3p
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    Additional mRNA sequence: 

    AB209181.1 AL359602.1 AL834498.1 BC019831.1 NR_036614.1 

    4 DOTS entries:

    DT.211642  DT.91752298  DT.100745025  DT.102827244 

    Selected AceView cDNA sequences (see all 61):

    BC019831 CB128836 CD637914 AI364264 BM467980 BI035543 BQ100931 AI653271 
    AI523594 BU625832 AI417436 AA877100 CB116909 AI023291 AI637797 AI074351 
    AI218564 AI499806 BU623925 BX478015 BU628135 BQ723527 AA452367 C04167 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DCLK2    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
    SP1:                          -                 -           -                                                                                 
    SP2:                          -                             -                                                                       -         
    SP3:                          -                 -           -                                                                       -         
    SP4:                                            -     -                                                                                       


    ECgene alternative splicing isoforms for DCLK2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCLK2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DCLK2 Expression
    About this image


    DCLK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Epiblast (Early Embryonic Tissues)
             Epiblast-like cells
     
     Eye (Sensory Organs)
             Retinal Pigmented Epithelium
    DCLK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCLK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591683

    UniProtKB/Swiss-Prot: DCLK2_HUMAN, Q8N568
    Tissue specificity: Expressed in the brain, heart and eyes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DCLK2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dclk21 , 5 doublecortin-like kinase 21, 5 89.02(n)1
    94.29(a)1
      3 (37.88 cM)5
    707621  NM_001195496.11  NP_001182425.11 
     867861505 
    chicken
    (Gallus gallus)
    Aves DCLK21 doublecortin-like kinase 2 81.24(n)
    89.1(a)
      422473  XM_003641161.2  XP_003641209.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCLK26
    doublecortin-like kinase 2
    78(a)
    1 ↔ 1
    5(132979442-133090561)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004872961 serine/threonine-protein kinase DCLK2-like 75.48(n)
    83.82(a)
      100487296  XM_002933500.2  XP_002933546.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dclk21 doublecortin-like kinase 2 71.21(n)
    77.17(a)
      572548  NM_001135121.1  NP_001128593.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175281 CG17528 51.39(n)
    47.68(a)
      3355134  NM_001042998.2  NP_001036463.1 
    worm
    (Caenorhabditis elegans)
    Secernentea zyg-86
    Protein ZYG-8 (zyg-8) mRNA, complete cds
    31(a)
    1 → many
    III(12061739-12072276) WBGene00006993


    ENSEMBL Gene Tree for DCLK2 (if available)
    TreeFam Gene Tree for DCLK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCLK2 gene
    PNCK2  CAMK1G2  PSKH22  DCX2  CAMK2A2  CAMK1D2  DCLK12  PSKH12  
    CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    Selected SIMAP similar genes for DCLK2 using alignment to 2 protein entries:     DCLK2_HUMAN (see all proteins) (see all similar genes):
    MGC45428    DCLK1    DCX    DCLK3    CAMK1D    DAPK3
    PNCK    PHKG1    PHKG2    PSKH1    CAMK1    CAMK4
    KIN27    PRKAA1    CAMK2D    DAPK2    PAK4    MKNK1

    DCLK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCLK2 (see all 3615)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs341607351,2
    C--146730697(+) TTTTT-/T/TT  
            
    GAGAC
    3 -- int11NA 2
    rs1120669031,2
    C--150858289(+) GAAAA-/ACACACA 3 -- int11Minor allele frequency- AC:0.50CSA 2
    rs1476814951,2
    --150997542(+) CCAACC/TGACAA 3 -- us2k10--------
    rs1129006521,2
    F--150997562(+) ACACTT/CAAGCA 3 -- us2k12Minor allele frequency- C:0.02CSA WA 120
    rs795800191,2
    F--150997565(+) CTTAAA/GCAACT 3 -- us2k10--------
    rs783071741,2
    C,F--150997583(+) AAGGTA/GCTCAT 3 -- us2k11Minor allele frequency- G:0.03EA 120
    rs1864685771,2
    --150997631(+) GGGCTC/GTCTTG 3 -- us2k10--------
    rs1917670491,2
    --150997662(+) AGTCAA/GGCCTT 3 -- us2k10--------
    rs1839374621,2
    --150997809(+) ATTTGC/TTTCTA 3 -- us2k10--------
    rs283742051,2
    C,F--150997822(+) GCAATA/GGTTTA 3 -- us2k17Minor allele frequency- G:0.12NA WA CSA EA 366

    HapMap Linkage Disequilibrium report for DCLK2 (150999426 - 151178609 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DCLK2 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673603CNV Deletion23128226
    nsv507204CNV Insertion20534489
    nsv509018CNV Insertion20534489
    nsv4546CNV Insertion18451855
    nsv261CNV Insertion15895083
    esv1001185CNV Insertion20482838
    nsv292617CNV Loss16902084
    nsv880256CNV Gain21882294
    nsv880258CNV Gain21882294
    nsv830111CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCLK2
    DNA2.0 Custom Variant and Variant Library Synthesis for DCLK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613166    OMIM disorders: --

    7 diseases for DCLK2:    
    About MalaCards
    lissencephaly    quadriplegia    labyrinthitis    retinitis
    cerebritis    neuronitis    malaria

    1 disease from the University of Copenhagen DISEASES database for DCLK2:
    Lissencephaly

    DCLK2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DCLK2

    Export disorders for DCLK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCLK2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DCLK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The doublecortin gene family and disorders of neuronal structure. (PubMed id 20236041)1, 2 Dijkmans T.F.... Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010)
    2. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. (PubMed id 18075264)1, 2 Tuy F.P.D.... Francis F. (Dev. Neurosci. 2008)
    3. The evolving doublecortin (DCX) superfamily. (PubMed id 16869982)1, 2 Reiner O.... Bergmann S. (BMC Genomics 2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. (PubMed id 15611072)1, 9 Edelman A.M....Sigurdson W. (J. Biol. Chem. 2005)
    6. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    7. Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. (PubMed id 22589738)1 Fox C.S....Borecki I.B. (PLoS Genet. 2012)
    8. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    9. Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. (PubMed id 19342486)1 Kerjan G....Gleeson J.G. (Proc. Natl. Acad. Sci. U.S.A. 2009)
    10. Gene trapping: an antibody-dependent approach for verifying integration in your favorite gene. (PubMed id 18618084)1 Gorelik A....Reiner O. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 166614 HGNC: 19002 AceView: MGC45428 Ensembl:ENSG00000170390 euGenes: HUgn166614
    ECgene: DCLK2 H-InvDB: DCLK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCLK2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCLK2 gene:
    Search GeneIP for patents involving DCLK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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