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Aliases for DCLK2 Gene

Aliases for DCLK2 Gene

  • Doublecortin Like Kinase 2 2 3 5
  • Doublecortin-Like Kinase 2 2 3 4
  • Doublecortin Domain-Containing Protein 3B 3 4
  • Doublecortin-Like And CAM Kinase-Like 2 3 4
  • Doublecortin And CaM Kinase-Like 2 2 3
  • CaMK-Like CREB Regulatory Kinase 2 3 4
  • EC 2.7.11.1 4 61
  • CLICK-II 3 4
  • DCAMKL2 3 4
  • CLICK2 3 4
  • DCDC3B 3 4
  • DCK2 3 4
  • CL2 3 4
  • Serine/Threonine-Protein Kinase DCLK2 3
  • EC 2.7.11 61
  • CLIK2 3
  • DCDC3 3

External Ids for DCLK2 Gene

Previous HGNC Symbols for DCLK2 Gene

  • DCAMKL2

Previous GeneCards Identifiers for DCLK2 Gene

  • GC04P151219
  • GC04P150999
  • GC04P146723

Summaries for DCLK2 Gene

Entrez Gene Summary for DCLK2 Gene

  • This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCLK2 Gene

DCLK2 (Doublecortin Like Kinase 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK1.

UniProtKB/Swiss-Prot for DCLK2 Gene

  • Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK2 Gene

Genomics for DCLK2 Gene

Regulatory Elements for DCLK2 Gene

Enhancers for DCLK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DCLK2 on UCSC Golden Path with GeneCards custom track

Promoters for DCLK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCLK2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCLK2 Gene

Chromosome:
4
Start:
150,078,274 bp from pter
End:
150,257,457 bp from pter
Size:
179,184 bases
Orientation:
Plus strand

Genomic View for DCLK2 Gene

Genes around DCLK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCLK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK2 Gene

Proteins for DCLK2 Gene

  • Protein details for DCLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N568-DCLK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase DCLK2
    Protein Accession:
    Q8N568
    Secondary Accessions:
    • C9J5Q9
    • Q59GC8
    • Q8N399

    Protein attributes for DCLK2 Gene

    Size:
    766 amino acids
    Molecular mass:
    83606 Da
    Quaternary structure:
    • Binds to and stabilizes microtubules. Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin.
    SequenceCaution:
    • Sequence=BAD92418.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCLK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCLK2 Gene

Post-translational modifications for DCLK2 Gene

Other Protein References for DCLK2 Gene

Domains & Families for DCLK2 Gene

Gene Families for DCLK2 Gene

Suggested Antigen Peptide Sequences for DCLK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N568

UniProtKB/Swiss-Prot:

DCLK2_HUMAN :
  • The doublecortin domains are involved in the colocalization with microtubules.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The doublecortin domains are involved in the colocalization with microtubules.
  • Contains 2 doublecortin domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with DCLK2: view

Function for DCLK2 Gene

Molecular function for DCLK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).

Enzyme Numbers (IUBMB) for DCLK2 Gene

Gene Ontology (GO) - Molecular Function for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DCLK2: view
genes like me logo Genes that share phenotypes with DCLK2: view

Animal Models for DCLK2 Gene

MGI Knock Outs for DCLK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for DCLK2

CRISPR Products

miRNA for DCLK2 Gene

miRTarBase miRNAs that target DCLK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCLK2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCLK2 Gene

Localization for DCLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCLK2 Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCLK2 Gene COMPARTMENTS Subcellular localization image for DCLK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
genes like me logo Genes that share ontologies with DCLK2: view

Pathways & Interactions for DCLK2 Gene

SuperPathways for DCLK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IEA --
GO:0021766 hippocampus development IEA --
GO:0021860 pyramidal neuron development IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCLK2: view

No data available for Pathways by source and SIGNOR curated interactions for DCLK2 Gene

Drugs & Compounds for DCLK2 Gene

(1) Drugs for DCLK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DCLK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DCLK2: view

Transcripts for DCLK2 Gene

Unigene Clusters for DCLK2 Gene

Doublecortin-like kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCLK2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -

Relevant External Links for DCLK2 Gene

GeneLoc Exon Structure for
DCLK2
ECgene alternative splicing isoforms for
DCLK2

Expression for DCLK2 Gene

mRNA expression in normal human tissues for DCLK2 Gene

Protein differential expression in normal tissues from HIPED for DCLK2 Gene

This gene is overexpressed in Fetal Brain (23.9), Brain (12.4), Frontal cortex (7.4), Cervix (6.9), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCLK2 Gene



Protein tissue co-expression partners for DCLK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCLK2 Gene:

DCLK2

SOURCE GeneReport for Unigene cluster for DCLK2 Gene:

Hs.591683

mRNA Expression by UniProt/SwissProt for DCLK2 Gene:

Q8N568-DCLK2_HUMAN
Tissue specificity: Expressed in the brain, heart and eyes.
genes like me logo Genes that share expression patterns with DCLK2: view

Primer Products

No data available for mRNA differential expression in normal tissues for DCLK2 Gene

Orthologs for DCLK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCLK2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCLK2 34
  • 90.97 (n)
  • 97.3 (a)
DCLK2 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCLK2 34
  • 93.26 (n)
  • 97.6 (a)
DCLK2 35
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dclk2 34
  • 89.02 (n)
  • 94.29 (a)
Dclk2 16
Dclk2 35
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCLK2 34
  • 99.7 (n)
  • 99.49 (a)
DCLK2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dclk2 34
  • 88.47 (n)
  • 94.36 (a)
oppossum
(Monodelphis domestica)
Mammalia DCLK2 35
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCLK2 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCLK2 34
  • 81.24 (n)
  • 89.1 (a)
DCLK2 35
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCLK2 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487296 34
  • 75.48 (n)
  • 83.82 (a)
zebrafish
(Danio rerio)
Actinopterygii dclk2 34
  • 71.21 (n)
  • 77.17 (a)
BX005047.1 35
  • 78 (a)
OneToMany
dclk2 35
  • 70 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009034 34
  • 53.71 (n)
  • 49.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG17528 34
  • 51.39 (n)
  • 47.68 (a)
CG17528 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zyg-8 35
  • 31 (a)
OneToMany
Species where no ortholog for DCLK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCLK2 Gene

ENSEMBL:
Gene Tree for DCLK2 (if available)
TreeFam:
Gene Tree for DCLK2 (if available)

Paralogs for DCLK2 Gene

Paralogs for DCLK2 Gene

genes like me logo Genes that share paralogs with DCLK2: view

Variants for DCLK2 Gene

Sequence variations from dbSNP and Humsavar for DCLK2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs56327537 - 150,079,382(+) CCCAG(G/T)GTGTC nc-transcript-variant, reference, missense
rs34386880 - 150,220,761(+) TGACC(A/G)TTGCA nc-transcript-variant, reference, missense
rs35745104 - 150,240,445(+) CATAC(A/G)TACTT nc-transcript-variant, reference, missense
rs759398144 - 150,102,690(+) AAGCC(A/G)TGCGG nc-transcript-variant, reference, missense
rs727426 -- 150,221,063(-) ATTGA(C/G)AGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCLK2 Gene

Variant ID Type Subtype PubMed ID
dgv2918n106 CNV deletion 24896259
esv1001185 CNV insertion 20482838
esv2673603 CNV deletion 23128226
esv3569747 CNV loss 25503493
esv3602651 CNV loss 21293372
esv3602652 CNV loss 21293372
esv3602654 CNV loss 21293372
esv3894052 CNV gain 25118596
nsv1022132 CNV gain 25217958
nsv1074223 CNV deletion 25765185
nsv1123855 CNV deletion 24896259
nsv1149616 CNV insertion 26484159
nsv261 CNV insertion 15895083
nsv292617 CNV deletion 16902084
nsv4546 CNV insertion 18451855
nsv507204 OTHER sequence alteration 20534489
nsv509018 CNV insertion 20534489
nsv830111 CNV gain 17160897
nsv949829 CNV deletion 24416366
nsv949830 CNV deletion 24416366

Variation tolerance for DCLK2 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCLK2 Gene

Human Gene Mutation Database (HGMD)
DCLK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCLK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCLK2 Gene

Disorders for DCLK2 Gene

Relevant External Links for DCLK2

Genetic Association Database (GAD)
DCLK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCLK2

No disorders were found for DCLK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCLK2 Gene

Publications for DCLK2 Gene

  1. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3 4 65
  2. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. (PMID: 18075264) Tuy F.P.D. … Francis F. (Dev. Neurosci. 2008) 3 4 65
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 3 4 65
  4. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. (PMID: 15611072) Edelman A.M. … Sigurdson W. (J. Biol. Chem. 2005) 3 22 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65

Products for DCLK2 Gene

Sources for DCLK2 Gene

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