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Aliases for DCLK2 Gene

Aliases for DCLK2 Gene

  • Doublecortin Like Kinase 2 2 3 5
  • Doublecortin Domain-Containing Protein 3B 3 4
  • Doublecortin-Like And CAM Kinase-Like 2 3 4
  • Doublecortin And CaM Kinase-Like 2 2 3
  • CaMK-Like CREB Regulatory Kinase 2 3 4
  • Doublecortin-Like Kinase 2 2 4
  • EC 2.7.11.1 4 58
  • CLICK-II 3 4
  • DCAMKL2 3 4
  • CLICK2 3 4
  • DCDC3B 3 4
  • DCK2 3 4
  • CL2 3 4
  • Serine/Threonine-Protein Kinase DCLK2 3
  • EC 2.7.11 58
  • CLIK2 3
  • DCDC3 3

External Ids for DCLK2 Gene

Previous HGNC Symbols for DCLK2 Gene

  • DCAMKL2

Previous GeneCards Identifiers for DCLK2 Gene

  • GC04P151219
  • GC04P150999
  • GC04P146723

Summaries for DCLK2 Gene

Entrez Gene Summary for DCLK2 Gene

  • This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCLK2 Gene

DCLK2 (Doublecortin Like Kinase 2) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK1.

UniProtKB/Swiss-Prot for DCLK2 Gene

  • Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).

Additional gene information for DCLK2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK2 Gene

Genomics for DCLK2 Gene

Regulatory Elements for DCLK2 Gene

Enhancers for DCLK2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H150126 0.9 Ensembl ENCODE 34 +48.7 48682 1 CBFB JUNB EBF1 BATF JUND POLR2A CREM RUNX3 DCLK2 GC04P150129
GH04H150175 1 VISTA ENCODE 25.8 +98.5 98461 2 JUND POLR2A RCOR1 DCLK2 RNU7-194P GC04P150129
GH04H150077 0.9 ENCODE 18.8 +0.3 258 1 ZNF2 GLIS2 ELK4 SP3 OVOL3 ZEB2 ZNF398 KLF16 GLIS1 ZBTB26 DCLK2 GC04P150129
GH04H150130 0.4 ENCODE 34 +52.9 52902 1 JUND POLR2A DCLK2 GC04P150129 RNU7-194P
GH04H150180 0.5 ENCODE 24.9 +103.5 103489 1 MXI1 RFX1 POLR2A BMI1 DCLK2 RNU7-194P GC04P150129
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCLK2 on UCSC Golden Path with GeneCards custom track

Promoters for DCLK2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000174638 526 2001 ZNF2 GLIS2 ELK4 OVOL3 ZEB2 ZNF398 KLF16 GLIS1 ZBTB26 CTCF

Genomic Location for DCLK2 Gene

Chromosome:
4
Start:
150,078,274 bp from pter
End:
150,257,457 bp from pter
Size:
179,184 bases
Orientation:
Plus strand

Genomic View for DCLK2 Gene

Genes around DCLK2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCLK2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCLK2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK2 Gene

Proteins for DCLK2 Gene

  • Protein details for DCLK2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N568-DCLK2_HUMAN
    Recommended name:
    Serine/threonine-protein kinase DCLK2
    Protein Accession:
    Q8N568
    Secondary Accessions:
    • C9J5Q9
    • Q59GC8
    • Q8N399

    Protein attributes for DCLK2 Gene

    Size:
    766 amino acids
    Molecular mass:
    83606 Da
    Quaternary structure:
    • Binds to and stabilizes microtubules. Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin.
    SequenceCaution:
    • Sequence=BAD92418.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCLK2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCLK2 Gene

Selected DME Specific Peptides for DCLK2 Gene

Q8N568:
  • GVITYILL
  • GPLYTVCGTPTYVAPEIIAETGYGLKVD
  • LGDFGLA
  • NEVSILRRVKHPNI
  • GNFAVVK
  • HRDIKPEN
  • LVMELVKGGDLFDAITS

Post-translational modifications for DCLK2 Gene

Domains & Families for DCLK2 Gene

Gene Families for DCLK2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for DCLK2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N568

UniProtKB/Swiss-Prot:

DCLK2_HUMAN :
  • The doublecortin domains are involved in the colocalization with microtubules.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • The doublecortin domains are involved in the colocalization with microtubules.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with DCLK2: view

Function for DCLK2 Gene

Molecular function for DCLK2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).

Enzyme Numbers (IUBMB) for DCLK2 Gene

Phenotypes From GWAS Catalog for DCLK2 Gene

Gene Ontology (GO) - Molecular Function for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA --
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with DCLK2: view
genes like me logo Genes that share phenotypes with DCLK2: view

Animal Models for DCLK2 Gene

MGI Knock Outs for DCLK2:

Animal Model Products

  • Taconic Biosciences Mouse Models for DCLK2

CRISPR Products

miRNA for DCLK2 Gene

miRTarBase miRNAs that target DCLK2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCLK2
  • Applied Biological Materials Clones for DCLK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCLK2 Gene

Localization for DCLK2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCLK2 Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCLK2 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 2
plasma membrane 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule IEA --
GO:0015630 microtubule cytoskeleton IBA --
genes like me logo Genes that share ontologies with DCLK2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCLK2 Gene

Pathways & Interactions for DCLK2 Gene

SuperPathways for DCLK2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCLK2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA,IEA --
GO:0006468 protein phosphorylation IEA --
GO:0016310 phosphorylation IEA --
GO:0018105 peptidyl-serine phosphorylation IBA,IEA --
GO:0018107 peptidyl-threonine phosphorylation IBA --
genes like me logo Genes that share ontologies with DCLK2: view

No data available for Pathways by source and SIGNOR curated interactions for DCLK2 Gene

Drugs & Compounds for DCLK2 Gene

(1) Drugs for DCLK2 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ATP Nutra Agonist 0

(1) Additional Compounds for DCLK2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DCLK2: view

Transcripts for DCLK2 Gene

Unigene Clusters for DCLK2 Gene

Doublecortin-like kinase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DCLK2
  • Applied Biological Materials Clones for DCLK2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: - -

Relevant External Links for DCLK2 Gene

GeneLoc Exon Structure for
DCLK2
ECgene alternative splicing isoforms for
DCLK2

Expression for DCLK2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCLK2 Gene

Protein differential expression in normal tissues from HIPED for DCLK2 Gene

This gene is overexpressed in Fetal Brain (23.9), Brain (12.4), Frontal cortex (7.4), Cervix (6.9), and Retina (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCLK2 Gene



Protein tissue co-expression partners for DCLK2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCLK2 Gene:

DCLK2

SOURCE GeneReport for Unigene cluster for DCLK2 Gene:

Hs.591683

mRNA Expression by UniProt/SwissProt for DCLK2 Gene:

Q8N568-DCLK2_HUMAN
Tissue specificity: Expressed in the brain, heart and eyes.

Evidence on tissue expression from TISSUES for DCLK2 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with DCLK2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCLK2 Gene

Orthologs for DCLK2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCLK2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCLK2 33 34
  • 99.7 (n)
dog
(Canis familiaris)
Mammalia DCLK2 33 34
  • 93.26 (n)
oppossum
(Monodelphis domestica)
Mammalia DCLK2 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCLK2 33 34
  • 90.97 (n)
mouse
(Mus musculus)
Mammalia Dclk2 33 16 34
  • 89.02 (n)
rat
(Rattus norvegicus)
Mammalia Dclk2 33
  • 88.47 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCLK2 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCLK2 33 34
  • 81.24 (n)
lizard
(Anolis carolinensis)
Reptilia DCLK2 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487296 33
  • 75.48 (n)
zebrafish
(Danio rerio)
Actinopterygii BX005047.1 34
  • 78 (a)
OneToMany
dclk2 33 34
  • 71.21 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009034 33
  • 53.71 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17528 33 34
  • 51.39 (n)
worm
(Caenorhabditis elegans)
Secernentea zyg-8 34
  • 31 (a)
OneToMany
Species where no ortholog for DCLK2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCLK2 Gene

ENSEMBL:
Gene Tree for DCLK2 (if available)
TreeFam:
Gene Tree for DCLK2 (if available)

Paralogs for DCLK2 Gene

Paralogs for DCLK2 Gene

genes like me logo Genes that share paralogs with DCLK2: view

Variants for DCLK2 Gene

Sequence variations from dbSNP and Humsavar for DCLK2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000013072 -- 150,247,634(+) TCGAC(C/G)AGATC nc-transcript-variant, reference, missense
rs1000023961 -- 150,208,045(+) GATAG(A/G)CTTAT intron-variant
rs1000025310 -- 150,163,449(+) AAATA(C/T)CATTC intron-variant
rs1000041695 -- 150,121,721(+) CCATC(A/G)GAAGA intron-variant
rs1000045844 -- 150,115,698(+) TGACC(A/G)GGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCLK2 Gene

Variant ID Type Subtype PubMed ID
dgv2918n106 CNV deletion 24896259
esv1001185 CNV insertion 20482838
esv2673603 CNV deletion 23128226
esv3569747 CNV loss 25503493
esv3602651 CNV loss 21293372
esv3602652 CNV loss 21293372
esv3602654 CNV loss 21293372
esv3894052 CNV gain 25118596
nsv1022132 CNV gain 25217958
nsv1074223 CNV deletion 25765185
nsv1123855 CNV deletion 24896259
nsv1149616 CNV insertion 26484159
nsv261 CNV insertion 15895083
nsv292617 CNV deletion 16902084
nsv4546 CNV insertion 18451855
nsv507204 OTHER sequence alteration 20534489
nsv509018 CNV insertion 20534489
nsv830111 CNV gain 17160897
nsv949829 CNV deletion 24416366
nsv949830 CNV deletion 24416366

Variation tolerance for DCLK2 Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCLK2 Gene

Human Gene Mutation Database (HGMD)
DCLK2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCLK2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCLK2 Gene

Disorders for DCLK2 Gene

Relevant External Links for DCLK2

Genetic Association Database (GAD)
DCLK2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCLK2

No disorders were found for DCLK2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCLK2 Gene

Publications for DCLK2 Gene

  1. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans TF … Vreugdenhil E (Central nervous system agents in medicinal chemistry 2010) 3 4 60
  2. Alternative transcripts of Dclk1 and Dclk2 and their expression in doublecortin knockout mice. (PMID: 18075264) Tuy FP … Francis F (Developmental neuroscience 2008) 3 4 60
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O … Bergmann S (BMC genomics 2006) 3 4 60
  4. Doublecortin kinase-2, a novel doublecortin-related protein kinase associated with terminal segments of axons and dendrites. (PMID: 15611072) Edelman AM … Sigurdson W (The Journal of biological chemistry 2005) 3 22 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for DCLK2 Gene

  • Addgene plasmids for DCLK2

Sources for DCLK2 Gene

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