Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCLK1 Gene

Aliases for DCLK1 Gene

  • Doublecortin Like Kinase 1 2 3 5
  • Doublecortin-Like Kinase 1 2 3 4
  • Doublecortin Domain-Containing Protein 3A 3 4
  • Doublecortin-Like And CAM Kinase-Like 1 3 4
  • EC 2.7.11.1 4 63
  • DCAMKL1 3 4
  • DCDC3A 3 4
  • Doublecortin And CaM Kinase-Like 1 2
  • EC 2.7.11 63
  • KIAA0369 4
  • CLICK1 3
  • DCLK 3
  • CL1 3

External Ids for DCLK1 Gene

Previous HGNC Symbols for DCLK1 Gene

  • DCAMKL1

Previous GeneCards Identifiers for DCLK1 Gene

  • GC13M035244
  • GC13M036343
  • GC13M017156

Summaries for DCLK1 Gene

Entrez Gene Summary for DCLK1 Gene

  • This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

GeneCards Summary for DCLK1 Gene

DCLK1 (Doublecortin Like Kinase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK33.

UniProtKB/Swiss-Prot for DCLK1 Gene

  • Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Gene Wiki entry for DCLK1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK1 Gene

Genomics for DCLK1 Gene

Regulatory Elements for DCLK1 Gene

Promoters for DCLK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCLK1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCLK1 Gene

Chromosome:
13
Start:
35,768,652 bp from pter
End:
36,132,020 bp from pter
Size:
363,369 bases
Orientation:
Minus strand

Genomic View for DCLK1 Gene

Genes around DCLK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCLK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK1 Gene

Proteins for DCLK1 Gene

  • Protein details for DCLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15075-DCLK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase DCLK1
    Protein Accession:
    O15075
    Secondary Accessions:
    • B7Z3E9
    • Q5VZY8
    • Q5VZZ0
    • Q5VZZ1

    Protein attributes for DCLK1 Gene

    Size:
    740 amino acids
    Molecular mass:
    82224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20824.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCLK1 Gene

    Alternative splice isoforms for DCLK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCLK1 Gene

Proteomics data for DCLK1 Gene at MOPED

Post-translational modifications for DCLK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DCLK1 (DCAMKL1)

Domains & Families for DCLK1 Gene

Gene Families for DCLK1 Gene

Suggested Antigen Peptide Sequences for DCLK1 Gene

Graphical View of Domain Structure for InterPro Entry

O15075

UniProtKB/Swiss-Prot:

DCLK1_HUMAN :
  • Contains 2 doublecortin domains.
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Domain:
  • Contains 2 doublecortin domains.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with DCLK1: view

Function for DCLK1 Gene

Molecular function for DCLK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Numbers (IUBMB) for DCLK1 Gene

Gene Ontology (GO) - Molecular Function for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,TAS 9747029
genes like me logo Genes that share ontologies with DCLK1: view
genes like me logo Genes that share phenotypes with DCLK1: view

Animal Models for DCLK1 Gene

MGI Knock Outs for DCLK1:

Animal Model Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCLK1 Gene

Localization for DCLK1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCLK1 Gene COMPARTMENTS Subcellular localization image for DCLK1 gene
Compartment Confidence
plasma membrane 4
cytosol 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCLK1 Gene

Pathways & Interactions for DCLK1 Gene

SuperPathways for DCLK1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006468 protein phosphorylation IEA --
GO:0007409 axonogenesis IEA --
GO:0007417 central nervous system development TAS 10051403
GO:0009615 response to virus IEP 16548883
genes like me logo Genes that share ontologies with DCLK1: view

No data available for Pathways by source and SIGNOR curated interactions for DCLK1 Gene

Drugs & Compounds for DCLK1 Gene

(1) Drugs for DCLK1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with DCLK1: view

Transcripts for DCLK1 Gene

Unigene Clusters for DCLK1 Gene

Doublecortin-like kinase 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: - -
SP2:
SP3: -

Relevant External Links for DCLK1 Gene

GeneLoc Exon Structure for
DCLK1
ECgene alternative splicing isoforms for
DCLK1

Expression for DCLK1 Gene

mRNA expression in normal human tissues for DCLK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCLK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Hypothalamus (x4.1), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for DCLK1 Gene

This gene is overexpressed in Fetal Brain (31.4), Frontal cortex (13.1), and Brain (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCLK1 Gene



SOURCE GeneReport for Unigene cluster for DCLK1 Gene Hs.507755

mRNA Expression by UniProt/SwissProt for DCLK1 Gene

O15075-DCLK1_HUMAN
Tissue specificity: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.
genes like me logo Genes that share expression patterns with DCLK1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for DCLK1 Gene

Orthologs for DCLK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCLK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCLK1 36
  • 94 (a)
OneToOne
DCLK1 35
  • 99.73 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia DCLK1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCLK1 36
  • 94 (a)
OneToOne
DCLK1 35
  • 93.73 (n)
  • 99.85 (a)
mouse
(Mus musculus)
Mammalia Dclk1 16
Dclk1 36
  • 91 (a)
OneToOne
Dclk1 35
  • 89.89 (n)
  • 98.4 (a)
oppossum
(Monodelphis domestica)
Mammalia DCLK1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCLK1 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCLK1 35
  • 86.1 (n)
  • 96.71 (a)
DCLK1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
-- 36
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dckl1b 36
  • 77 (a)
OneToMany
dclk1a 36
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17528 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zyg-8 35
  • 49.81 (n)
  • 45.35 (a)
zyg-8 36
  • 33 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NNK1 38
rice
(Oryza sativa)
Liliopsida Os.4465 35
Species with no ortholog for DCLK1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DCLK1 Gene

ENSEMBL:
Gene Tree for DCLK1 (if available)
TreeFam:
Gene Tree for DCLK1 (if available)

Paralogs for DCLK1 Gene

Paralogs for DCLK1 Gene

genes like me logo Genes that share paralogs with DCLK1: view

Variants for DCLK1 Gene

Sequence variations from dbSNP and Humsavar for DCLK1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_045673 A gastric adenocarcinoma sample
VAR_045674 A gastric adenocarcinoma sample
VAR_045675 A gastric adenocarcinoma sample
VAR_045676 A gastric adenocarcinoma sample
VAR_045677 -

Structural Variations from Database of Genomic Variants (DGV) for DCLK1 Gene

Variant ID Type Subtype PubMed ID
nsv832580 CNV Loss 17160897
esv4657 CNV Deletion 18987735
esv2747262 CNV Deletion 23290073
esv2670454 CNV Deletion 23128226
nsv64246 CNV Loss 16902084
nsv524786 CNV Loss 19592680
nsv510948 CNV Complex 20534489
nsv509501 CNV Insertion 20534489
esv3500 CNV Duplication 18987735
esv2674324 CNV Deletion 23128226
esv4059 CNV Complex 18987735
esv2772 CNV Deletion 18987735
esv2429709 CNV Insertion 19546169
esv2671550 CNV Deletion 23128226
esv22934 CNV Loss 19812545
esv27255 CNV Loss 19812545
nsv518674 CNV Loss 19592680
nsv522911 CNV Loss 19592680
esv267546 CNV Insertion 20981092
nsv899992 CNV Loss 21882294
nsv899993 CNV Gain 21882294

Variation tolerance for DCLK1 Gene

Residual Variation Intolerance Score: 7.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCLK1 Gene

HapMap Linkage Disequilibrium report
DCLK1
Human Gene Mutation Database (HGMD)
DCLK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCLK1 Gene

Disorders for DCLK1 Gene

Relevant External Links for DCLK1

Genetic Association Database (GAD)
DCLK1
Human Genome Epidemiology (HuGE) Navigator
DCLK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCLK1

No disorders were found for DCLK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCLK1 Gene

Publications for DCLK1 Gene

  1. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. (PMID: 9747029) Omori Y. … Fujiwara T. (J. Hum. Genet. 1998) 2 3 4 23 67
  2. Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells. (PMID: 20228126) Verissimo C.S. … Vreugdenhil E. (Endocr. Relat. Cancer 2010) 3 23
  3. Functional differences between two DCLK splice variants. (PMID: 14741399) Engels B.M. … Vreugdenhil E. (Brain Res. Mol. Brain Res. 2004) 3 23
  4. The DCX-domain tandems of doublecortin and doublecortin-like kinase. (PMID: 12692530) Kim M.H. … Derewenda Z.S. (Nat. Struct. Biol. 2003) 3 23
  5. Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase. (PMID: 12595708) Kim M.H. … Derewenda Z.S. (Acta Crystallogr. D Biol. Crystallogr. 2003) 3 23

Products for DCLK1 Gene

Sources for DCLK1 Gene

Back to Top

Content