Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCLK1 Gene

Aliases for DCLK1 Gene

  • Doublecortin Like Kinase 1 2 3 5
  • Doublecortin Domain-Containing Protein 3A 3 4
  • Doublecortin-Like And CAM Kinase-Like 1 3 4
  • Doublecortin-Like Kinase 1 2 4
  • EC 2.7.11.1 4 58
  • DCAMKL1 3 4
  • DCDC3A 3 4
  • Serine/Threonine-Protein Kinase DCLK1 3
  • Doublecortin And CaM Kinase-Like 1 2
  • EC 2.7.11 58
  • KIAA0369 4
  • CLICK1 3
  • DCLK 3
  • CL1 3

External Ids for DCLK1 Gene

Previous HGNC Symbols for DCLK1 Gene

  • DCAMKL1

Previous GeneCards Identifiers for DCLK1 Gene

  • GC13M035244
  • GC13M036343
  • GC13M017156

Summaries for DCLK1 Gene

Entrez Gene Summary for DCLK1 Gene

  • This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length nature and biological validity of some variants have not been defined. These variants encode different isoforms, which are differentially expressed and have different kinase activities.[provided by RefSeq, Sep 2010]

GeneCards Summary for DCLK1 Gene

DCLK1 (Doublecortin Like Kinase 1) is a Protein Coding gene. Among its related pathways are B Cell Receptor Signaling Pathway (sino) and Neuroscience. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is DCLK2.

UniProtKB/Swiss-Prot for DCLK1 Gene

  • Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.

Gene Wiki entry for DCLK1 Gene

Additional gene information for DCLK1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCLK1 Gene

Genomics for DCLK1 Gene

Regulatory Elements for DCLK1 Gene

Enhancers for DCLK1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H036154 1.2 FANTOM5 Ensembl ENCODE dbSUPER 16.3 -23.0 -22997 1 POLR2A PRDM4 DCLK1 CCDC169 SOHLH2 SPART
GH13H036163 1.1 ENCODE dbSUPER 12 -31.9 -31943 1 PKNOX1 FEZF1 RFX5 ZNF366 OVOL3 CEBPB TSHZ1 ZEB2 ZNF843 NFIC DCLK1 RNU6-71P SOHLH2
GH13H035978 1.2 Ensembl ENCODE dbSUPER 10.6 +152.2 152215 2 CTCF MXI1 RAD21 GATA3 SMC3 ZNF143 FOS MAFK ZNF362 ZNF654 RNU6-71P DCLK1 MAB21L1 GC13P036065 LOC105370163
GH13H036156 0.9 ENCODE dbSUPER 12 -26.1 -26095 2 CEBPB KLF17 FEZF1 EP300 PRDM6 JUND MAFF ZNF366 FOXP2 MAFK DCLK1 CCDC169 SOHLH2 RNU6-71P
GH13H036096 0.4 ENCODE 11.7 +35.5 35451 0 NR2F1 DCLK1 RFXAP NMTRQ-TTG10-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCLK1 on UCSC Golden Path with GeneCards custom track

Promoters for DCLK1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000061273 920 1001 MXI1 KLF1 ZNF777 ZSCAN4 SIN3A ZNF140 HIC1 E2F1 ZNF121 ZFHX2

Genomic Location for DCLK1 Gene

Chromosome:
13
Start:
35,768,652 bp from pter
End:
36,132,020 bp from pter
Size:
363,369 bases
Orientation:
Minus strand

Genomic View for DCLK1 Gene

Genes around DCLK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCLK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCLK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCLK1 Gene

Proteins for DCLK1 Gene

  • Protein details for DCLK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15075-DCLK1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase DCLK1
    Protein Accession:
    O15075
    Secondary Accessions:
    • B7Z3E9
    • Q5VZY8
    • Q5VZZ0
    • Q5VZZ1

    Protein attributes for DCLK1 Gene

    Size:
    740 amino acids
    Molecular mass:
    82224 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20824.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCLK1 Gene

    Alternative splice isoforms for DCLK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCLK1 Gene

Selected DME Specific Peptides for DCLK1 Gene

O15075:
  • LVMELVKGGDLFDAITS
  • GVITYILL
  • GPLYTVCGTPTYVAPEIIAETGYGLKVD
  • LGDFGLA
  • NEVSILRRVKHPNI
  • GNFAVVK
  • HRDIKPEN

Post-translational modifications for DCLK1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DCLK1 (DCAMKL1)

Domains & Families for DCLK1 Gene

Gene Families for DCLK1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for DCLK1 Gene

Graphical View of Domain Structure for InterPro Entry

O15075

UniProtKB/Swiss-Prot:

DCLK1_HUMAN :
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.
genes like me logo Genes that share domains with DCLK1: view

Function for DCLK1 Gene

Molecular function for DCLK1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot Function:
Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Enzyme Numbers (IUBMB) for DCLK1 Gene

Phenotypes From GWAS Catalog for DCLK1 Gene

Gene Ontology (GO) - Molecular Function for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 9747029
GO:0004674 protein serine/threonine kinase activity IBA --
GO:0005057 signal transducer activity, downstream of receptor TAS 10036192
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with DCLK1: view
genes like me logo Genes that share phenotypes with DCLK1: view

Animal Models for DCLK1 Gene

MGI Knock Outs for DCLK1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCLK1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCLK1 Gene

Localization for DCLK1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCLK1 gene
Compartment Confidence
plasma membrane 4
cytosol 3
cytoskeleton 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005887 integral component of plasma membrane TAS 10036192
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with DCLK1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCLK1 Gene

Pathways & Interactions for DCLK1 Gene

genes like me logo Genes that share pathways with DCLK1: view

Pathways by source for DCLK1 Gene

2 Sino Biological pathways for DCLK1 Gene
1 Cell Signaling Technology pathway for DCLK1 Gene

Gene Ontology (GO) - Biological Process for DCLK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006468 protein phosphorylation TAS 9747029
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development TAS 10036192
GO:0007409 axonogenesis IEA --
genes like me logo Genes that share ontologies with DCLK1: view

No data available for SIGNOR curated interactions for DCLK1 Gene

Drugs & Compounds for DCLK1 Gene

(1) Drugs for DCLK1 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with DCLK1: view

Transcripts for DCLK1 Gene

Unigene Clusters for DCLK1 Gene

Doublecortin-like kinase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCLK1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DCLK1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: - -
SP2:
SP3: -

Relevant External Links for DCLK1 Gene

GeneLoc Exon Structure for
DCLK1
ECgene alternative splicing isoforms for
DCLK1

Expression for DCLK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCLK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCLK1 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Hypothalamus (x4.1), and Brain - Cortex (x4.1).

Protein differential expression in normal tissues from HIPED for DCLK1 Gene

This gene is overexpressed in Fetal Brain (31.4), Frontal cortex (13.1), and Brain (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCLK1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DCLK1 Gene:

DCLK1

SOURCE GeneReport for Unigene cluster for DCLK1 Gene:

Hs.507755

mRNA Expression by UniProt/SwissProt for DCLK1 Gene:

O15075-DCLK1_HUMAN
Tissue specificity: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B isoforms are expressed abundantly in both fetal and adult brain.

Evidence on tissue expression from TISSUES for DCLK1 Gene

  • Nervous system(5)
  • Intestine(2.6)
  • Stomach(2)
genes like me logo Genes that share expression patterns with DCLK1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCLK1 Gene

Orthologs for DCLK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCLK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCLK1 33 34
  • 99.73 (n)
oppossum
(Monodelphis domestica)
Mammalia DCLK1 34
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCLK1 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCLK1 33 34
  • 93.73 (n)
mouse
(Mus musculus)
Mammalia Dclk1 33 16 34
  • 89.89 (n)
cow
(Bos Taurus)
Mammalia DCLK1 34
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCLK1 33 34
  • 86.1 (n)
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 93 (a)
OneToMany
-- 34
  • 82 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii dckl1b 34
  • 77 (a)
OneToMany
dclk1a 34
  • 67 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17528 34
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea zyg-8 33 34
  • 49.81 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes NNK1 36
rice
(Oryza sativa)
Liliopsida Os.4465 33
Species where no ortholog for DCLK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DCLK1 Gene

ENSEMBL:
Gene Tree for DCLK1 (if available)
TreeFam:
Gene Tree for DCLK1 (if available)

Paralogs for DCLK1 Gene

Paralogs for DCLK1 Gene

genes like me logo Genes that share paralogs with DCLK1: view

Variants for DCLK1 Gene

Sequence variations from dbSNP and Humsavar for DCLK1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_045673 A gastric adenocarcinoma sample
VAR_045674 A gastric adenocarcinoma sample
VAR_045675 A gastric adenocarcinoma sample
VAR_045676 A gastric adenocarcinoma sample
rs1000002557 -- 35,920,805(+) GCTGC(A/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCLK1 Gene

Variant ID Type Subtype PubMed ID
dgv3117n54 CNV loss 21841781
dgv3118n54 CNV loss 21841781
dgv948n106 CNV tandem duplication 24896259
esv22934 CNV loss 19812545
esv2429709 CNV insertion 19546169
esv2670454 CNV deletion 23128226
esv2671550 CNV deletion 23128226
esv2674324 CNV deletion 23128226
esv27255 CNV loss 19812545
esv2747262 CNV deletion 23290073
esv2772 CNV loss 18987735
esv3303266 CNV mobile element insertion 20981092
esv3327110 CNV insertion 20981092
esv3500 OTHER sequence alteration 18987735
esv3550313 CNV deletion 23714750
esv3631771 CNV loss 21293372
esv3631772 CNV loss 21293372
esv3631773 CNV loss 21293372
esv4059 OTHER complex 18987735
esv4657 CNV loss 18987735
nsv1070582 CNV deletion 25765185
nsv1132855 CNV insertion 24896259
nsv1138213 CNV deletion 24896259
nsv1138214 CNV deletion 24896259
nsv1147365 CNV deletion 26484159
nsv1152524 CNV insertion 26484159
nsv479188 CNV novel sequence insertion 20440878
nsv509501 CNV insertion 20534489
nsv510948 OTHER complex 20534489
nsv518674 CNV loss 19592680
nsv522911 CNV loss 19592680
nsv524786 CNV loss 19592680
nsv561489 CNV loss 21841781
nsv561492 CNV loss 21841781
nsv64246 CNV deletion 16902084
nsv832580 CNV loss 17160897
nsv952537 CNV duplication 24416366
nsv976103 CNV duplication 23825009
nsv977225 CNV duplication 23825009

Variation tolerance for DCLK1 Gene

Residual Variation Intolerance Score: 7.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.00; 20.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCLK1 Gene

Human Gene Mutation Database (HGMD)
DCLK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCLK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCLK1 Gene

Disorders for DCLK1 Gene

Relevant External Links for DCLK1

Genetic Association Database (GAD)
DCLK1
Human Genome Epidemiology (HuGE) Navigator
DCLK1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCLK1

No disorders were found for DCLK1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCLK1 Gene

Publications for DCLK1 Gene

  1. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. (PMID: 9747029) Omori Y … Fujiwara T (Journal of human genetics 1998) 2 3 4 22 60
  2. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). (PMID: 10036192) Sossey-Alaoui K … Srivastava AK (Genomics 1999) 2 3 4 60
  3. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PMID: 21998595) N'Diaye A … Haiman CA (PLoS genetics 2011) 3 45 60
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  5. Silencing of the microtubule-associated proteins doublecortin-like and doublecortin-like kinase-long induces apoptosis in neuroblastoma cells. (PMID: 20228126) Verissimo CS … Vreugdenhil E (Endocrine-related cancer 2010) 3 22 60

Products for DCLK1 Gene

Sources for DCLK1 Gene

Content
Loading form....