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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCLK1 Gene

protein-coding   GIFtS: 62
GCID: GC13M036343

doublecortin-like kinase 1

(Previous name: doublecortin and CaM kinase-like 1 )
(Previous symbol: DCAMKL1)
 Explore 10 diseases affiliated with
DCLK1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DCLK1    

Aliases
for DCLK1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Doublecortin-Like Kinase 11 2 3     Doublecortin-Like And CAM Kinase-Like 12 3
DCAMKL11 2 3 5     EC 2.7.11.13 8
DCDC3A1 2 3     CL12 5
KIAA03691 3 5     CLICK12 5
DCLK1 2     Serine/Threonine-Protein Kinase DCLK12
Doublecortin And CaM Kinase-Like 11 2     EC 2.7.118
Doublecortin Domain-Containing Protein 3A2 3     

External Ids:    HGNC: 27001   Entrez Gene: 92012   Ensembl: ENSG000001330837   OMIM: 6047425   UniProtKB: O150753   

Export aliases for DCLK1 gene to outside databases

Previous GC identifers: GC13M035244 GC13M017156


Summaries
for DCLK1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DCLK1:
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this
gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a
C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent
protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which
mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is
independent of its protein kinase activity. The encoded protein is involved in several different cellular processes,
including neuronal migration, retrograde transport, neuronal apoptosis and neurogenesis. This gene is up-regulated by
brain-derived neurotrophic factor and associated with memory and general cognitive abilities. Multiple transcript
variants generated by two alternative promoter usage and alternative splicing have been reported, but the full-length
nature and biological validity of some variants have not been defined. These variants encode different isoforms, which
are differentially expressed and have different kinase activities.(provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
Function: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the
developing brain. May also participate in functions of the mature nervous system

Gene Wiki entry for DCLK1


Genomic Views
for DCLK1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCLK1 gene promoter:
         STAT5B   SRF   Pax-5   Tal-1   SRF (504 AA)   C/EBPalpha   E47   CHOP-10   AREB6   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DCLK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCLK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCLK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.3

DCLK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCLK1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M036343:  view genomic region     (about GC identifiers)

Start:
 36,343,122 bp from pter      End:
 36,705,464 bp from pter
Size:
 362,343 bases      Orientation:
 minus strand

Proteins
for DCLK1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase DCLK1  
Size: 740 amino acids; 82224 Da
Sequence caution: Sequence=BAA20824.2; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for DCLK1:
1MFW (3D)        1MG4 (3D)        1UF0 (3D)    
Secondary accessions: B7Z3E9 Q5VZY8 Q5VZZ0 Q5VZZ1
Alternative splicing: 4 isoforms:  O15075-1   O15075-2   O15075-3   O15075-4   

Explore the universe of human proteins at neXtProt for DCLK1: NX_O15075

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O15075

    • 4/7 DME Specific Peptides for DCLK1 (O15075) (see all 7)
     GNFAVVK  LGDFGLA  HRDIKPEN  GVITYILL 

    DCLK1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_001182344.1  NP_001182345.1  NP_001182359.1  NP_004725.1  

    ENSEMBL proteins: 
     ENSP00000255448   ENSP00000353846   ENSP00000369223   ENSP00000369222  

    Human Recombinant Protein Products: 
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    Uscn Proteins for DCLK1

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005887integral to plasma membrane TAS10036192


    DCLK1 for ontologies           About GeneDecksing



    DCLK1 Antibody Products: 
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    Uscn ELISAs and CLIAs for DCLK1

    Protein Domains /
    Families
    for DCLK1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DCLK1 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O15075

    ProtoNet protein and cluster: O15075

    1 Blocks protein family: IPB003533 Doublecortin

    UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 2 doublecortin domains
    Similarity: Contains 1 protein kinase domain


    Function
    for DCLK1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
    Function: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the
    developing brain. May also participate in functions of the mature nervous system
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    8/169 QIAGEN miScript miRNA Assays for microRNAs that regulate DCLK1 (see all 169):
    hsa-miR-124* hsa-miR-640 hsa-miR-3938 hsa-miR-199a-3p hsa-miR-1260b hsa-miR-3074-3p hsa-miR-3921 hsa-miR-502-3p
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    Inhib. RNA
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    OriGene shRNA RFP: DCLK1
    OriGene siRNA: DCLK1
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for DCLK1

    In Situ Assay
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         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCLK1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9747029
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0005057receptor signaling protein activity TAS10036192
    GO:0005524ATP binding IEA--
    GO:0016301kinase activity ----


    DCLK1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DCLK1:
     Upregulation of Wnt/beta-caten  Wnt reporter downregulated 

    Animal Models:
         Mouse knock-outs for DCLK1: Dclk1tm1Caw Dclk1tm1.1Jgg
         5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dclk1):
     cellular  mortality/aging  nervous system  no phenotypic analysis  reproductive system 

    DCLK1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DCLK1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCLK1

    5/18 Interacting proteins for DCLK1 (O150753) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC39A7Q925043I2D: score=5 
    FBLN1P231423I2D: score=4 
    LMNB2Q032523I2D: score=4 
    MAPRE1Q156913I2D: score=4 
    OLA1Q9NTK53I2D: score=4 
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006468protein phosphorylation TAS9747029
    GO:0007399nervous system development TAS10036192
    GO:0007409axonogenesis ----
    GO:0007417central nervous system development TAS10051403


    DCLK1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DCLK1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCLK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCLK1

    1 HMDB Compound for DCLK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    1 Novoseek chemical compound relationship for DCLK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 4 14741399 (1), 10550327 (1), 11473121 (1)

    Search CenterWatch for drugs/clinical trials and news about DCLK1 

    Transcripts
    for DCLK1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DCLK1 gene (4 alternative transcripts): 
    NM_001195415.1  NM_001195416.1  NM_001195430.1  NM_004734.4  

    Unigene Cluster for DCLK1:

    Doublecortin-like kinase 1
    Hs.507755  [show with all ESTs]
    Unigene Representative Sequence: NM_004734
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000255448(uc001uvf.3) ENST00000360631 ENST00000379893(uc001uve.4 uc010teh.2 uc010abk.3)
    ENST00000477664 ENST00000486239 ENST00000460982(uc001uvh.4) ENST00000379892


    miRNA
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    8/169 QIAGEN miScript miRNA Assays for microRNAs that regulate DCLK1 (see all 169):
    hsa-miR-124* hsa-miR-640 hsa-miR-3938 hsa-miR-199a-3p hsa-miR-1260b hsa-miR-3074-3p hsa-miR-3921 hsa-miR-502-3p
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: DCLK1
    OriGene siRNA: DCLK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCLK1
    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCLK1

    Additional cDNA sequence: 

    AB002367.1 AF052152.1 AF070534.1 AK123427.1 AK295777.1 AK299059.1 AK299829.1 AK308925.1 
    AK311183.1 AK311195.1 AK311434.1 AK311438.1 AK311459.1 BC152456.1 CR627093.1 

    6 DOTS entries:

    DT.212699  DT.105227  DT.97793316  DT.100729376  DT.91686214  DT.120769111 

    24/111 AceView cDNA sequences (see all 111):

    AI419597 BQ719452 BU147508 AL157652 AB002367 AL157657 NM_004734 BM729248 
    AI359804 AA360492 BX451944 CR618189 AA033625 AA829556 AW264475 AI656707 
    BX451943 BI598267 AU128204 AU125252 BU733351 CD652985 BF593665 CB269320 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DCLK1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                -           -                                                                                 
    SP2:                                                                                                                              
    SP3:                                                                                                              -               


    ECgene alternative splicing isoforms for DCLK1

    Expression
    for DCLK1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCLK1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTATTCCTCT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DCLK1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeVisceral White AdiposeVisceral White AdipocytesAdipose
    Reproductive SystemEarly GonadTestis Somatic CellsTestis
    AdiposeVisceral White AdiposeAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    ES04(HES-4) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H7 (WA07) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Line H9 (WA09) (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Matrigel embedded cells (Derivation of cardio...)

    See DCLK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCLK1

    SOURCE GeneReport for Unigene cluster: Hs.507755

    UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
    Tissue specificity: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney. In
    adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate, testis,
    ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain whereas type B
    isoforms are expressed abundantly in both fetal and adult brain

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    In Situ
    Assay Products:     
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    Orthologs
    for DCLK1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCLK1 gene from 7/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DCLK11 doublecortin-like kinase 1 86.1(n)
    96.71(a)    		   418903  XM_417099.3  XP_417099.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DCLK16
    		 --
    		 81(a)
    		 1 ↔ 1
    		 3(182065511-182107198)
    zebrafish
    (Danio rerio)    		 Actinopterygii dckl1b6
    dclk1a6
    		 doublecortin-like kinase 1a
    		 77(a)
    76(a)
    		 1 ↔ many
    1 ↔ many
    		 15(32988827-33052209)
    10(35765475-35895175)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG175286
    		 --
    		 33(a)
    		 1 → many
    		 2R(704674-711821)
    worm
    (Caenorhabditis elegans)    		 Secernentea F32D8.16
    zyg-86
    		 Serine/threonine-protein kinase zyg-8
    		 28(a)
    15(a)
    		 many ↔ many
    many ↔ many
    		 V(10880818-10883292)
    III(12061639-12071897)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PEPKR21 serine/threonine-protein kinase PEPKR2 49.73(n)
    40.4(a)    		   837824  NM_101138.3  NP_172728.1 
    rice
    (Oryza sativa)    		 Liliopsida Os.44652 Oryza sativa (japonica cultivar-group) cDNA clone0 more 77.64(n)    NM_185473.1 


    ENSEMBL Gene Tree for DCLK1 (if available)
    TreeFam Gene Tree for DCLK1 (if available) 

    Paralogs
    for DCLK1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCLK1 gene
    PNCK2  CAMK1G2  PSKH22  DCX2  DCLK22  CAMK2A2  CAMK1D2  PSKH12  
    CAMK42  CAMK2D2  DCLK32  CAMKV2  CAMK2G2  CAMK2B2  CAMK12  
    18/30 SIMAP similar genes for DCLK1 using alignment to 2 protein entries:     DCLK1_HUMAN (see all proteins) (see all similar genes):
    DCX    MGC45428    DCLK2    DCLK3    CAMK1D    PRKAA1
    CAMK1    PNCK    DAPK2    CAMK2D    PSKH1    PRKY
    CDK4    DAPK3    PHKG1    PHKG2    CAMK1G    CAMK4

    DCLK1 for paralogs           About GeneDecksing



    Genomic Variants
    for DCLK1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6125 NCBI SNPs in DCLK1 are shown (see all 6125)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 13 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs731761531,2
    		C,--36342291(+) TTCACA/GCCAAG 3 -- ds50010--------
    rs1475596411,2
    		--36342340(+) AGCCTC/GGTAAA 3 -- ds50010--------
    rs2003376421,2
    		C,--36342608(+) GAAAA-/GCTCGA 3 -- ds50010--------
    rs1420076561,2
    		--36342650(+) TGCAAC/TTTTCT 3 -- ds50010--------
    rs79903031,2
    		C,F,H,--36342854(+) TATGAA/CAAGGG 3 -- ut3115Minor allele frequency- C:0.01NS EA NA WA CSA 674
    rs1852266621,2
    		--36342987(+) TCCCCC/TTAAGA 3 -- ut310--------
    rs1911145981,2
    		--36343084(+) CTGAGC/GAGCGT 3 -- ut310--------
    rs128656801,2
    		C,F,H,--36343088(+) GGAGCG/ATACCC 3 -- ut317Minor allele frequency- A:0.01NS EA NA 544
    rs1458456731,2
    		--36343295(+) TCTCAC/TTCCAC 3 -- ut310--------
    rs1475216701,2
    		C,--36343349(+) TTCTG-/AAAAAT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for DCLK1 (36343122 - 36593122 bp, first 250kb of DCLK1)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for DCLK1
         5 CNVs: 86785 86786 66418 86784 66419
         5 Indels: 42842 39968 101704 41260 11666
    Human Gene Mutation Database (HGMD): DCLK1

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    Disorders / Diseases
    for DCLK1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DCLK1 for disorders           About GeneDecksing

    OMIM gene information: 604742    OMIM disorders: --

    10 diseases for DCLK1:    About MalaCards
    neuronal migration disorders    neuronitis    zellweger syndrome    lissencephaly
    hepatitis c    rhabdomyosarcoma    hepatitis    cerebritis
    pancreatitis    prostatitis

    1 disease from the University of Copenhagen DISEASES database for DCLK1:
    Lissencephaly
    Human Genome Epidemiology (HuGE) Navigator: DCLK1 (2 documents)

    Export disorders for DCLK1 gene to outside databases

    Publications
    for DCLK1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCLK1 gene, integrated from 9 sources (see all 64):
    (articles sorted by number of sources associating them with DCLK1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. (PubMed id 9747029)1, 2, 3, 9 Omori Y....Fujiwara T. (1998)
    2. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). (PubMed id 10036192)1, 2, 3 Sossey-Alaoui K. and Srivastava A.K. (1999)
    3. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
    4. Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). (PubMed id 10051403)1, 2 Matsumoto N.... Ledbetter D.H. (1999)
    5. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
    6. Cleavage of doublecortin-like kinase by calpain releases an active kinase fragment from a microtubule anchorage domain. (PubMed id 11473121)1, 9 Burgess H.A. and Reiner O. (2001)
    7. Alternative splice variants of doublecortin-like kinase are differentially expressed and have different kinase activities. (PubMed id 11884394)1, 9 Burgess H.A. and Reiner O. (2002)
    8. The DCX-domain tandems of doublecortin and doublecortin-like kinase. (PubMed id 12692530)1, 9 Kim M.H....Derewenda Z.S. (2003)
    9. Purification and crystallization of the N-terminal domain from the human doublecortin-like kinase. (PubMed id 12595708)1, 9 Kim M.H....Derewenda Z.S. (2003)
    10. Functional differences between two DCLK splice variants. (PubMed id 14741399)1, 9 Engels B.M....Vreugdenhil E. (2004)

    External Searches for DCLK1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DCLK1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9201 HGNC: 2700 AceView: DCAMKL1 Ensembl:ENSG00000133083 euGenes: HUgn9201
    ECgene: DCLK1 H-InvDB: DCLK1

    Other Databases showing DCLK1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0369

    Specialized Databases showing DCLK1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCLK1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DCLK1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DCLK1 gene:
    Search GeneIP for patents involving DCLK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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