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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCLK1 Gene

protein-coding   GIFtS: 64
GCID: GC13M036343

Doublecortin-Like Kinase 1

(Previous name: doublecortin and CaM kinase-like 1)
(Previous symbol: DCAMKL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Doublecortin-Like Kinase 11 2 3     CL12 5
DCAMKL11 2 3 5     CLICK12 5
Doublecortin And CaM Kinase-Like 11 2     KIAA03693 5
Doublecortin Domain-Containing Protein 3A2 3     DCLK2
Doublecortin-Like And CAM Kinase-Like 12 3     Serine/Threonine-Protein Kinase DCLK12
DCDC3A2 3     EC 2.7.118
EC 2.7.11.13 8     

External Ids:    HGNC: 27001   Entrez Gene: 92012   Ensembl: ENSG000001330837   OMIM: 6047425   UniProtKB: O150753   

Export aliases for DCLK1 gene to outside databases

Previous GC identifers: GC13M035244 GC13M017156


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCLK1 Gene:
This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by
this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule
polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to
Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the
protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing
activity of the encoded protein is independent of its protein kinase activity. The encoded protein is involved in
several different cellular processes, including neuronal migration, retrograde transport, neuronal apoptosis and
neurogenesis. This gene is up-regulated by brain-derived neurotrophic factor and associated with memory and
general cognitive abilities. Multiple transcript variants generated by two alternative promoter usage and
alternative splicing have been reported, but the full-length nature and biological validity of some variants have
not been defined. These variants encode different isoforms, which are differentially expressed and have different
kinase activities.(provided by RefSeq, Sep 2010)

GeneCards Summary for DCLK1 Gene: 
DCLK1 (doublecortin-like kinase 1) is a protein-coding gene. Diseases associated with DCLK1 include neuronal migration disorders, and zellweger syndrome. GO annotations related to this gene include protein serine/threonine kinase activity and receptor signaling protein activity. An important paralog of this gene is DCLK3.

UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
Function: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in
the developing brain. May also participate in functions of the mature nervous system

Gene Wiki entry for DCLK1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCLK1 gene promoter:
         STAT5B   SRF   Pax-5   Tal-1   SRF (504 AA)   C/EBPalpha   E47   CHOP-10   AREB6   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DCLK1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCLK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCLK1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q13   Ensembl cytogenetic band:  13q13.3   HGNC cytogenetic band: 13q13.3

DCLK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCLK1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M036343:  view genomic region     (about GC identifiers)

Start:
36,342,789 bp from pter      End:
36,705,514 bp from pter
Size:
362,726 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase DCLK1  
Size: 740 amino acids; 82224 Da
Sequence caution: Sequence=BAA20824.2; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for DCLK1:
1MFW (3D)        1MG4 (3D)        1UF0 (3D)    
Secondary accessions: B7Z3E9 Q5VZY8 Q5VZZ0 Q5VZZ1
Alternative splicing: 4 isoforms:  O15075-1   O15075-2   O15075-3   O15075-4   

Explore the universe of human proteins at neXtProt for DCLK1: NX_O15075

Explore proteomics data for DCLK1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15075

  • 4/7 DME Specific Peptides for DCLK1 (O15075) (see all 7)
     GNFAVVK  LGDFGLA  HRDIKPEN  GVITYILL 

    DCLK1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCLK1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001182344.1  NP_001182345.1  NP_001182359.1  NP_004725.1  

    ENSEMBL proteins: 
     ENSP00000369223   ENSP00000255448   ENSP00000353846   ENSP00000369222  

    Human Recombinant Protein Products for DCLK1: 
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    Cloud-Clone Corp. Proteins for DCLK1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS10036192

    DCLK1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for DCLK1 
    Cloud-Clone Corp. CLIAs for DCLK1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: doublecortin-like kinase 1 
    DCAMKL family

    5/7 InterPro protein domains (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry O15075

    ProtoNet protein and cluster: O15075

    1 Blocks protein domain: IPB003533 Doublecortin

    UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily
    Similarity: Contains 2 doublecortin domains
    Similarity: Contains 1 protein kinase domain


    DCLK1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCLK1_HUMAN, O15075
    Function: Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in
    the developing brain. May also participate in functions of the mature nervous system
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity TAS9747029
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005057receptor signaling protein activity TAS10036192
    GO:0005524ATP binding IEA--
         
    DCLK1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DCLK1:
     Upregulation of Wnt/beta-caten  Wnt reporter downregulated 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dclk1):
     cellular  digestive/alimentary  endocrine/exocrine gland  mortality/aging  nervous system 
     no phenotypic analysis  reproductive system  tumorigenesis 

    DCLK1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DCLK1: Dclk1tm1Caw Dclk1tm1.1Jgg

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DCLK1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DCLK1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCLK1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCLK1 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCLK1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCLK1

    5/23 Interacting proteins for DCLK1 (O150753) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206288Q925043I2D: score=5 
    ENSG00000224399Q925043I2D: score=5 
    ENSG00000226614Q925043I2D: score=5 
    ENSG00000227402Q925043I2D: score=5 
    ENSG00000229802Q925043I2D: score=5 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0006468protein phosphorylation TAS9747029
    GO:0007399nervous system development TAS10036192
    GO:0007409axonogenesis ----
    GO:0007417central nervous system development TAS10051403

    DCLK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCLK1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCLK1

    1 HMDB Compound for DCLK1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for DCLK1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    calcium 0 4 14741399 (1), 10550327 (1), 11473121 (1)

    Search CenterWatch for drugs/clinical trials and news about DCLK1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCLK1 gene (4 alternative transcripts): 
    NM_001195415.1  NM_001195416.1  NM_001195430.1  NM_004734.4  

    Unigene Cluster for DCLK1:

    Doublecortin-like kinase 1
    Hs.507755  [show with all ESTs]
    Unigene Representative Sequence: NM_004734
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379893(uc001uve.4 uc010teh.2 uc010abk.3) ENST00000255448(uc001uvf.3)
    ENST00000360631 ENST00000477664 ENST00000486239 ENST00000460982(uc001uvh.4)
    ENST00000379892
    miRNA
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    hsa-miR-124* hsa-miR-640 hsa-miR-3938 hsa-miR-199a-3p hsa-miR-1260b hsa-miR-3074-3p hsa-miR-3921 hsa-miR-502-3p
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    Additional mRNA sequence: 

    AB002367.1 AF052152.1 AF070534.1 AK123427.1 AK295777.1 AK299059.1 AK299829.1 AK308925.1 
    AK311183.1 AK311195.1 AK311434.1 AK311438.1 AK311459.1 BC152456.1 CR627093.1 

    6 DOTS entries:

    DT.212699  DT.105227  DT.97793316  DT.100729376  DT.91686214  DT.120769111 

    24/111 AceView cDNA sequences (see all 111):

    AI419597 AA829556 AL157657 AI656707 AA360492 AA033625 BX451944 BQ719452 
    AL157652 AW264475 AI359804 BM729248 BU147508 NM_004734 CR618189 AB002367 
    AI379505 BF196172 CR627093 CD105965 AI860075 BE857363 AI088788 AI206625 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DCLK1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
    SP1:                                -           -                                                                                 
    SP2:                                                                                                                              
    SP3:                                                                                                              -               


    ECgene alternative splicing isoforms for DCLK1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCLK1 expression in normal human tissues (normalized intensities)      DCLK1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTCCTCT
    DCLK1 Expression
    About this image


    DCLK1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 12 entries
             Cerebral Cortex
             Subthalamic Nucleus   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Mandibular Process
             Human Calvarial Osteoblasts (HCO)   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Line H7 (WA07)
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
             ovary ; follicle cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             colon ; peripheral nerve/ganglion   

    See DCLK1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCLK1

    SOURCE GeneReport for Unigene cluster: Hs.507755

    UniProtKB/Swiss-Prot: DCLK1_HUMAN, O15075
    Tissue specificity: In fetal tissues, highly expressed in brain, detectable in lung and liver, but not in kidney.
    In adult tissues, expressed ubiquitously in the brain, detectable in the heart, liver, spleen, thymus, prostate,
    testis, ovary, small intestine and colon. The type A isoforms seem to be expressed predominantly in fetal brain
    whereas type B isoforms are expressed abundantly in both fetal and adult brain

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCLK1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCLK1 gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dclk11 , 5 doublecortin-like kinase 11, 5 89.89(n)1
    98.4(a)1
      3 (26.53 cM)5
    131751  NM_001195538.11  NP_001182467.11 
     552425265 
    chicken
    (Gallus gallus)
    Aves DCLK11 doublecortin-like kinase 1 86.1(n)
    96.71(a)
      418903  XM_417099.3  XP_417099.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    93(a)
    80(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    3(181840400-182046029)
    3(182065511-182107198)
    zebrafish
    (Danio rerio)
    Actinopterygii dckl1b6
    dclk1a6
    doublecortin-like kinase 1a
    77(a)
    75(a)
    1 ↔ many
    1 ↔ many
    15(32988827-33052209)
    10(35765475-35895175)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG175286
    CG101776
    --
    36(a)
    30(a)
    1 ↔ many
    possible ortholog
    2R(704674-711821)
    3R(19345868-19347305)
    worm
    (Caenorhabditis elegans)
    Secernentea zyg-86
    Serine/threonine-protein kinase zyg-8
    31(a)
    1 → many
    III(12061739-12071997)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PEPKR21 serine/threonine-protein kinase PEPKR2 49.73(n)
    40.4(a)
      837824  NM_101138.3  NP_172728.1 
    rice
    (Oryza sativa)
    Liliopsida Os.44652 Oryza sativa (japonica cultivar-group) cDNA clone0 more 77.64(n)    NM_185473.1 


    ENSEMBL Gene Tree for DCLK1 (if available)
    TreeFam Gene Tree for DCLK1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCLK1 gene
    DCLK32  DCX2  PRKD32  PRKD22  DCLK22  STK332  PRKD12  
    18/30 SIMAP similar genes for DCLK1 using alignment to 2 protein entries:     DCLK1_HUMAN (see all proteins) (see all similar genes):
    DCX    MGC45428    DCLK2    DCLK3    CAMK1D    PRKAA1
    CAMK1    PNCK    DAPK2    CAMK2D    PSKH1    PRKY
    CDK4    DAPK3    PHKG1    PHKG2    CAMK1G    CAMK4

    DCLK1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7158 SNPs in DCLK1 are shown (see all 7158)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0456744
    A gastric adenocarcinoma sample4--see VAR_0456742 T M mis40--------
    VAR_0456764
    A gastric adenocarcinoma sample4--see VAR_0456762 S F mis40--------
    VAR_0456734
    A gastric adenocarcinoma sample4--see VAR_0456732 G C mis40--------
    VAR_0456754
    A gastric adenocarcinoma sample4--see VAR_0456752 R Q mis40--------
    rs105918401,2
    C--17586966(+) TTTTT-/T/TT  
            
    AACAA
    1 -- int1 trp31NA 2
    rs731761531,2
    C--36342291(+) TTCACA/GCCAAG 3 -- ds50010--------
    rs1475596411,2
    --36342340(+) AGCCTC/GGTAAA 3 -- ds50010--------
    rs2003376421,2
    C--36342608(+) GAAAA-/GCTCGA 3 -- ds50010--------
    rs1420076561,2
    --36342650(+) TGCAAC/TTTTCT 3 -- ds50010--------
    rs79903031,2
    C,F,H--36342854(+) TATGAA/CAAGGG 3 -- ut3115Minor allele frequency- C:0.01NS EA NA WA CSA 674

    HapMap Linkage Disequilibrium report for DCLK1 (36342789 - 36592789 bp, first 250kb of DCLK1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for DCLK1 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2671550CNV Deletion23128226
    esv4657CNV Deletion18987735
    esv2674324CNV Deletion23128226
    esv2772CNV Deletion18987735
    esv2747262CNV Deletion23290073
    esv2670454CNV Deletion23128226
    esv3500CNV Duplication18987735
    nsv509501CNV Insertion20534489
    esv267546CNV Insertion20981092
    esv2429709CNV Insertion19546169


    Human Gene Mutation Database (HGMD): DCLK1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DCLK1
    DNA2.0 Custom Variant and Variant Library Synthesis for DCLK1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604742    OMIM disorders: --

    16 diseases for DCLK1:    About MalaCards
    neuronal migration disorders    zellweger syndrome    lissencephaly    attention deficit hyperactivity disorder
    neuronitis    barrett's esophagus    rhabdomyosarcoma    asthma
    hepatitis c    cerebritis    esophagitis    schizophrenia
    hepatitis    pancreatitis    prostatitis    breast cancer

    1 disease from the University of Copenhagen DISEASES database for DCLK1:
    Lissencephaly

    DCLK1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DCLK1
    Human Genome Epidemiology (HuGE) Navigator: DCLK1 (2 documents)

    Export disorders for DCLK1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCLK1 gene, integrated from 9 sources (see all 68):
    (articles sorted by number of sources associating them with DCLK1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression and chromosomal localization of KIAA0369, a putative kinase structurally related to Doublecortin. (PubMed id 9747029)1, 2, 3, 9 Omori Y....Fujiwara T. (1998)
    2. DCAMKL1, a brain-specific transmembrane protein on 13q12.3 that is similar to doublecortin (DCX). (PubMed id 10036192)1, 2, 3 Sossey-Alaoui K. and Srivastava A.K. (1999)
    3. Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. (PubMed id 21998595)1, 4 N'Diaye A....Haiman C.A. (2011)
    4. A genome-wide association study of optic disc paramet ers. (PubMed id 20548946)1, 4 Ramdas W.D....van Duijn C.M. (2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. Variants in doublecortin- and calmodulin kinase like 1, a gene up-regulated by BDNF, are associated with memory and general cognitiv e abilities. (PubMed id 19844571)1, 4 Le Hellard S....Steen V.M. (2009)
    7. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)1, 4 Newton-Cheh C....Larson M.G. (2007)
    8. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (2006)
    9. Genomic structure, chromosomal mapping, and expression pattern of human DCAMKL1 (KIAA0369), a homologue of DCX (XLIS). (PubMed id 10051403)1, 2 Matsumoto N.... Ledbetter D.H. (1999)
    10. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9201 HGNC: 2700 AceView: DCAMKL1 Ensembl:ENSG00000133083 euGenes: HUgn9201
    ECgene: DCLK1 H-InvDB: DCLK1

    (According to HUGE)
    About This Section
    HUGE: KIAA0369

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCLK1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCLK1 gene:
    Search GeneIP for patents involving DCLK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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