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DCK Gene

protein-coding   GIFtS: 70
GCID: GC04P071816

Deoxycytidine Kinase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deoxycytidine Kinase1 2
EC 2.7.1.743 8
Deoxynucleoside Kinase2
dCK3
EC 2.7.18

External Ids:    HGNC: 27041   Entrez Gene: 16332   Ensembl: ENSG000001561367   OMIM: 1254505   UniProtKB: P277073   

Export aliases for DCK gene to outside databases

Previous GC identifers: GC04P072099 GC04P072259 GC04P072325 GC04P072224 GC04P072078 GC04P067664


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCK Gene:
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their
nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic
agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these
compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its
relationship to drug resistance and sensitivity. (provided by RefSeq, Jul 2008)

GeneCards Summary for DCK Gene:
DCK (deoxycytidine kinase) is a protein-coding gene. Diseases associated with DCK include purine nucleoside phosphorylase deficiency, and neurofibrosarcoma. GO annotations related to this gene include protein homodimerization activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is TK2.

UniProtKB/Swiss-Prot: DCK_HUMAN, P27707
Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and
deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of
the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely
employed as antiviral and chemotherapeutic agents

Gene Wiki entry for DCK (Deoxycytidine kinase) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000004.12  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCK gene promoter:
         STAT5B   AML1a   p53   POU3F1   CUTL1   HNF-3beta   POU2F1   HFH-1   POU2F1a   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCK promoter sequence
   Search Chromatin IP Primers for DCK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3-q21.1   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3-q21.1

DCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCK gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P071816:  view genomic region     (about GC identifiers)

Start:
71,858,255 bp from pter      End:
71,896,631 bp from pter
Size:
38,377 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCK_HUMAN, P27707 (See protein sequence)
Recommended Name: Deoxycytidine kinase  
Size: 260 amino acids; 30519 Da
Subunit: Homodimer
Caution: Was shown to be phosphorylated and activated by CSNK1D/CK1 in vitro but probably not in vivo
(PubMed:20637175)
Selected PDB 3D structures from and Proteopedia for DCK (see all 35):
1P5Z (3D)        1P60 (3D)        1P61 (3D)        1P62 (3D)        2A2Z (3D)        2A30 (3D)    
Secondary accessions: B2R8V6 Q5TZY7 Q6FI11

Explore the universe of human proteins at neXtProt for DCK: NX_P27707

Explore proteomics data for DCK at MOPED

Post-translational modifications: 

  • Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK11
  • Ubiquitination2 at Lys34, Lys88, Lys117, Lys211, Lys254
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for DCK (P27707)
     KKISIEGNI  FERSVYSDRYIFA  EDWEVVPEPVARWCNVQSTQ 


    See DCK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000779.1  
    ENSEMBL proteins: 
     ENSP00000422971   ENSP00000286648   ENSP00000426389   ENSP00000425578   ENSP00000421508  
    Reactome Protein details: P27707

    DCK Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for DCK


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR002624 Deoxynucleoside_kinase

    Graphical View of Domain Structure for InterPro Entry P27707

    ProtoNet protein and cluster: P27707

    1 Blocks protein domain: IPB002624 Deoxynucleoside kinase

    UniProtKB/Swiss-Prot: DCK_HUMAN, P27707
    Similarity: Belongs to the DCK/DGK family


    DCK for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCK_HUMAN, P27707
    Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and
    deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of
    the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely
    employed as antiviral and chemotherapeutic agents
    Catalytic activity: NTP + deoxycytidine = NDP + dCMP
    Biophysicochemical properties: Kinetic parameters: KM=6.2 uM for deoxycytidine (dC); KM=15.5 uM for cytarabine
    (araC); KM=22 uM for gemcitabine (dC);

         Genatlas biochemistry entry for DCK:
    deoxycytidine kinase,pyrimidine salvage pathway

         Enzyme Numbers (IUBMB): EC 2.7.1.741 2 EC 2.7.12

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004137deoxycytidine kinase activity IDA12808445
    GO:0005524ATP binding IEA--
    GO:0008144drug binding IDA12808445
    GO:0016773phosphotransferase activity, alcohol group as acceptor IEA--
    GO:0019206nucleoside kinase activity EXP--
         
    DCK for ontologies           About GeneDecksing


    Phenotypes:
         5 GenomeRNAi human phenotypes for DCK:
     Decreased 12E8 and total tau p  Decreased telomerase activity  Gemcitabine induced cell-death  Increased cell death HMECs cel 
     Increased gamma-H2AX phosphory 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dck):
     cellular  hematopoietic system  immune system  normal 

    DCK for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dcktm1.1Radu for DCK

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCK
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCK
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCK

    miRNA
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    hsa-mir-128-3p (MIRT021886), hsa-mir-148b-3p (MIRT019296)

    Block miRNA regulation of human, mouse, rat DCK using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCK (see all 13):
    hsa-miR-411* hsa-miR-3164 hsa-miR-361-5p hsa-miR-548am hsa-miR-379* hsa-miR-148b hsa-miR-3065-5p hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidDCK 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DCK

    Gene Editing
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    Sino Biological Human cDNA Clone for DCK
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCK


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCK_HUMAN, P27707: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    mitochondrion2
    extracellular1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--

    DCK for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCK About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Purine metabolism (KEGG)
    Purine metabolism0.38
    purine deoxyribonucleosides salvage0.00
    Pyrimidine metabolism0.38
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Purine metabolism (REACTOME)
    Purine metabolism0.42
    Purine salvage0.00
    Metabolism of nucleotides0.42
    4superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
    superpathway of pyrimidine deoxyribonucleoside salvage0.46
    pyrimidine deoxyribonucleosides salvage0.00
    5Pyrimidine metabolism
    Pyrimidine metabolism0.33
    Pyrimidine salvage reactions0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    4 BioSystems Pathways for DCK
        purine deoxyribonucleosides salvage
    RB in Cancer
    pyrimidine deoxyribonucleosides salvage
    superpathway of pyrimidine deoxyribonucleoside salvage


    2 Reactome Pathways for DCK
        Purine salvage
    Pyrimidine salvage reactions

    2 PharmGKB Pathways for DCK
        Gemcitabine Pathway, Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics

    3 Kegg Pathways  (Kegg details for DCK):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways


    DCK for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCK
    Interactions:

        GeneGlobe Interaction Network for DCK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCK (P277072, 3 ENSP000002866484) via UniProtKB, MINT, STRING, and/or I2D (see all 56)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLM1Q8NBJ42, 3MINT-64962 I2D: score=5 
    MED19A0JLT22, 3MINT-64896 I2D: score=5 
    RXRGP484432, 3, ENSP000003529004MINT-8254089 I2D: score=2 STRING: ENSP00000352900
    DDX19BQ9UMR23I2D: score=4 
    DCKP277072MINT-8254078
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006220pyrimidine nucleotide metabolic process IDA12808445
    GO:0009157deoxyribonucleoside monophosphate biosynthetic process TAS1996353

    DCK for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCK

    6 HMDB Compounds for DCK    About this table
    CompoundSynonyms CAS #PubMed Ids
    Deoxycytidine1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)951-77-917296311
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    dCMP2'-Deoxycytidine 5'-monophosphate (see all 12)1032-65-1--

    Selected DrugBank Compounds for DCK (see all 13)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cladribine2-CdA (see all 5)4291-63-8enzymesubstrate19463072 19576186 19715446 20634380 20689698 17852710
    NelarabineGW-506U78 (see all 2)121032-29-9enzymesubstrate17344466 20616909 18516261 18035189 19825456
    Clofarabine-- 123318-82-1enzymesubstrate19576186 20631817 17852710
    FludarabineFAMP (see all 4)75607-67-9targetagonist15820918 16421443 20137114
    CytarabineAra-C (see all 26)147-94-4enzymesubstrate19842938 15492802
    GemcitabinedFdC (see all 4)95058-81-4enzymesubstrate19514966 20669326
    Lamivudine-- 134678-17-4enzymesubstrate19887088 15963349
    ZalcitabineDDC (see all 3)7481-89-2enzymesubstrate7763311 10585881
    Decitabine5-aza-2'-deoxycytidine (see all 3)2353-33-5enzyme--21127859
    Emtricitabine-- 143491-57-0enzymesubstrate17517847

    Selected Novoseek inferred chemical compound relationships for DCK gene (see all 97)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxycytidine 99.2 1059 8356916 (7), 9345319 (5), 7980770 (5), 9342341 (5) (see all 99)
    deoxynucleoside 94.6 40 11440177 (2), 12535661 (1), 15104248 (1), 11000580 (1) (see all 23)
    2-chlorodeoxyadenosine 91.8 133 8094016 (6), 7718326 (4), 9802328 (4), 9776315 (4) (see all 48)
    ara-ctp 91.3 22 7475275 (3), 19428333 (3), 2249330 (1), 7654012 (1) (see all 15)
    gemcitabine 90 298 12477049 (8), 16638857 (7), 15471562 (6), 11595723 (5) (see all 88)
    nucleoside 89.8 166 18377927 (4), 8625309 (3), 15950950 (3), 9598144 (3) (see all 78)
    deoxyguanosine 89.7 104 8962060 (4), 10575360 (3), 17897085 (3), 9593124 (3) (see all 50)
    cdamp 89.6 4 9533533 (1), 15135110 (1), 17065053 (1)
    cytarabine 89.5 156 11830489 (7), 10995016 (4), 12406011 (3), 10942400 (3) (see all 64)
    dctp 87.5 22 1406603 (2), 8962060 (2), 1917159 (1), 9215860 (1) (see all 16)



    DCK for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCK gene: 
    NM_000788.2  

    Unigene Cluster for DCK:

    Deoxycytidine kinase
    Hs.709  [show with all ESTs]
    Unigene Representative Sequence: CD014015
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509617 ENST00000286648(uc003hfx.3) ENST00000503359(uc011cbb.2)
    ENST00000504730 ENST00000504952 ENST00000509764
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DCK (see all 13):
    hsa-miR-411* hsa-miR-3164 hsa-miR-361-5p hsa-miR-548am hsa-miR-379* hsa-miR-148b hsa-miR-3065-5p hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmidDCK 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DCK (NM_000788)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCK
    Primer
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    OriGene qPCR primer pairs and template standards for DCK
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCK
      QuantiTect SYBR Green Assays in human, mouse, rat DCK
      QuantiFast Probe-based Assays in human, mouse, rat DCK

    Additional mRNA sequence: 

    AK303292.1 AK313523.1 BC103764.1 BC114617.1 BT019941.1 BT019942.1 CR536527.1 CR541876.1 
    JF806429.1 M60527.1 

    6 DOTS entries:

    DT.214721  DT.100649306  DT.99994300  DT.101981862  DT.91750417  DT.100720128 

    Selected AceView cDNA sequences (see all 143):

    CD014016 BQ879026 BM987644 CK904729 AW161391 BQ220213 CK904730 CD014015 
    BQ221914 BG779403 CD014014 BQ420469 BQ083320 CR541876 AU154063 CR536527 
    BG149683 BM918952 BM720582 AI275599 BG389564 BQ069129 CA310016 BI601939 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DCK    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:        -                                   -         
    SP2:        -                                             
    SP3:                                            -         
    SP4:        -                       -           -         


    ECgene alternative splicing isoforms for DCK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DCK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCAAAAAA
    DCK Expression
    About this image


    DCK expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
    DCK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.709
        Custom PCR Arrays for DCK
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCK gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dck1 , 5 deoxycytidine kinase1, 5 88.33(n)1
    93.46(a)1
      5 (43.96 cM)5
    131781  NM_007832.41  NP_031858.11 
     887649965 
    chicken
    (Gallus gallus)
    Aves DCK1 deoxycytidine kinase 78.39(n)
    81.82(a)
      422648  NM_001006451.1  NP_001006451.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCK6
    deoxycytidine kinase
    80(a)
    1 ↔ 1
    5(147222016-147234889)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68392 Xenopus laevis transcribed sequence with moderate similarity more 78.71(n)    CA981505.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.248582 Transcribed sequence with weak similarity to protein more 73.91(n)    57071408 
    fruit fly
    (Drosophila melanogaster)
    Insecta dnk6
    deoxyribonucleoside kinase
    27(a)
    1 → many
    3R(14806684-14808471)
    rice
    (Oryza sativa)
    Liliopsida Os05g04302001 Os05g0430200 54.71(n)
    45.11(a)
      4338875  NM_001062157.1  NP_001055622.1 


    ENSEMBL Gene Tree for DCK (if available)
    TreeFam Gene Tree for DCK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCK gene
    TK22  DGUOK2  
    7 SIMAP similar genes for DCK using alignment to 5 protein entries:     DCK_HUMAN (see all proteins):
    SPATS2L    ZNF212    ZNF564    NF2    DNAPTP3    DGUOK
    TK2

    DCK for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCK (see all 809)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1390060201,2
    --71732166(+) GAACTA/GGTGTT 1 -- us2k10--------
    rs1851374081,2
    --71732172(+) GTGTTC/TGAAAT 1 -- us2k10--------
    rs764598951,2
    --71732210(+) CATCAC/TTGTAA 1 -- us2k10--------
    rs1826481301,2
    --71732251(+) AACCAC/TACTTG 1 -- us2k10--------
    rs1181620671,2
    F--71732278(+) AACCCC/TAAGCC 1 -- us2k11Minor allele frequency- T:0.01EA 120
    rs758606981,2
    C--71732310(+) ACCAGC/TTCTGC 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs726464341,2
    C,F--71732482(+) TCTTCA/GGGCCT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs728541631,2
    C,F--71732499(+) TTCCTA/CGGATC 1 -- us2k12Minor allele frequency- C:0.13WA 120
    rs765672241,2
    C,F--71732652(+) CTGCTC/GTTTAT 1 -- us2k11Minor allele frequency- G:0.02NA 120
    rs1497320691,2
    C--71732692(+) TCTGG-/CTACAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCK (71858255 - 71896631 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DCK: --
    Human Gene Mutation Database (HGMD): DCK
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCK
    DNA2.0 Custom Variant and Variant Library Synthesis for DCK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 125450    OMIM disorders: --

    Selected diseases for DCK (see all 43):    
    About MalaCards
    purine nucleoside phosphorylase deficiency    neurofibrosarcoma    adenosine deaminase deficiency    uterine sarcoma
    pancreatic cancer    leiomyosarcoma    chronic lymphocytic leukemia    acute leukemia
    follicular lymphoma    colon adenocarcinoma    macroglobulinemia    herpes simplex
    acute myeloid leukemia    b-cell chronic lymphocytic leukemia    lymphoblastic leukemia    papillary thyroid carcinoma
    neutropenia    adenocarcinoma    ovarian cancer    pulmonary function

    2 diseases from the University of Copenhagen DISEASES database for DCK:
    Leukemia     Pancreatic cancer

    DCK for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for DCK gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 61.3 29 19099730 (2), 11896543 (2), 10961690 (1), 15037202 (1) (see all 17)
    leukemia lymphocytic chronic 56.7 13 12566084 (2), 11275369 (1), 20137114 (1), 7942271 (1) (see all 7)
    pancreatic cancer 54.5 32 18751396 (5), 19487279 (3), 16638857 (3), 20043109 (3) (see all 11)
    solid tumor 53.9 16 10961690 (3), 15276067 (2), 12477049 (1), 12604712 (1) (see all 7)
    leukemia hairy cell 51.7 1 7942271 (1)
    lymphocytic leukemia chronic b-cell 43.6 5 15202025 (1), 7942271 (1), 16778146 (1)
    nsclc 42.1 26 15471562 (4), 19500405 (2), 20211060 (2), 20436341 (2) (see all 7)
    acute leukemia 37.3 3 15571257 (1), 19099730 (1)
    hematologic malignancies 36.5 5 19099730 (2), 11896543 (1)
    aml adult 32 1 12628850 (1)

    Genetic Association Database (GAD): DCK
    Human Genome Epidemiology (HuGE) Navigator: DCK (12 documents)

    Export disorders for DCK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCK gene, integrated from 10 sources (see all 462):
    (articles sorted by number of sources associating them with DCK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK). (PubMed id 18974616)1, 4, 9 Kim S.R....Sawada J. (Drug Metab. Pharmacokinet. 2008)
    2. Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. (PubMed id 19159229)1, 2, 9 Hazra S.... Lavie A. (Biochemistry 2009)
    3. The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. (PubMed id 16421443)2, 7, 9 Zhang Y.... Ealick S.E. (Acta Crystallogr. D 2006)
    4. [Correlation of deoxycytidine kinase gene expression with fludarabine resistance in patients with chronic lymphocytic leukemia]. (PubMed id 20137114)1, 7, 9 Yao L....Li J.Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010)
    5. Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. (PubMed id 15564883)1, 4, 9 Shi J.Y....Chen S.J. (Pharmacogenetics 2004)
    6. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. (PubMed id 12808445)1, 2, 9 Sabini E.... Lavie A. (Nat. Struct. Biol. 2003)
    7. Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers. (PubMed id 16799820)1, 4, 9 Joerger M....Schellens J.H. (Eur. J. Clin. Pharmacol. 2006)
    8. Characterization of human deoxycytidine kinase. Correlation with cDNA sequences. (PubMed id 2013338)1, 2, 9 Eriksson S.... Bohman C. (FEBS Lett. 1991)
    9. Single nucleotide polymorphisms of gemcitabine metabolic genes and pancreatic cancer survival and drug toxicity. (PubMed id 20028759)1, 4, 9 Okazaki T....Li D. (Clin. Cancer Res. 2010)
    10. An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients. (PubMed id 17602053)1, 4, 9 Rha S.Y....Chung H.C. (Oncologist 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1633 HGNC: 2704 AceView: DCK Ensembl:ENSG00000156136 euGenes: HUgn1633
    ECgene: DCK Kegg: 1633 H-InvDB: DCK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DCK Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCK gene:
    Search GeneIP for patents involving DCK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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