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Aliases for DCK Gene

Aliases for DCK Gene

  • Deoxycytidine Kinase 2 3
  • EC 2.7.1.74 4 63
  • EC 2.7.1 63
  • DCK 4

External Ids for DCK Gene

Previous GeneCards Identifiers for DCK Gene

  • GC04P071816
  • GC04P072099
  • GC04P072259
  • GC04P072325
  • GC04P072224
  • GC04P072078
  • GC04P067664

Summaries for DCK Gene

Entrez Gene Summary for DCK Gene

  • Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCK Gene

DCK (Deoxycytidine Kinase) is a Protein Coding gene. Diseases associated with DCK include neurofibrosarcoma and pancreatic cancer. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include protein homodimerization activity and phosphotransferase activity, alcohol group as acceptor. An important paralog of this gene is TK2.

UniProtKB/Swiss-Prot for DCK Gene

  • Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Gene Wiki entry for DCK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCK Gene

Genomics for DCK Gene

Regulatory Elements for DCK Gene

Genomic Location for DCK Gene

Start:
70,992,538 bp from pter
End:
71,030,914 bp from pter
Size:
38,377 bases
Orientation:
Plus strand

Genomic View for DCK Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCK Gene

Proteins for DCK Gene

  • Protein details for DCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27707-DCK_HUMAN
    Recommended name:
    Deoxycytidine kinase
    Protein Accession:
    P27707
    Secondary Accessions:
    • B2R8V6
    • Q5TZY7
    • Q6FI11

    Protein attributes for DCK Gene

    Size:
    260 amino acids
    Molecular mass:
    30519 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DCK Gene

neXtProt entry for DCK Gene

Proteomics data for DCK Gene at MOPED

Selected DME Specific Peptides for DCK Gene

Post-translational modifications for DCK Gene

  • Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
  • Ubiquitination at Lys34, Lys88, Lys117, Lys211, and Lys254
  • Modification sites at PhosphoSitePlus

Other Protein References for DCK Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for DCK Gene

Protein Domains for DCK Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DCK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27707

UniProtKB/Swiss-Prot:

DCK_HUMAN :
  • P27707
Family:
  • Belongs to the DCK/DGK family.
genes like me logo Genes that share domains with DCK: view

No data available for Gene Families for DCK Gene

Function for DCK Gene

Molecular function for DCK Gene

GENATLAS Biochemistry: deoxycytidine kinase,pyrimidine salvage pathway
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=6.2 uM for deoxycytidine (dC) {ECO:0000269 PubMed:12808445}; KM=15.5 uM for cytarabine (araC) {ECO:0000269 PubMed:12808445}; KM=22 uM for gemcitabine (dC) {ECO:0000269 PubMed:12808445};
UniProtKB/Swiss-Prot CatalyticActivity: NTP + deoxycytidine = NDP + dCMP.
UniProtKB/Swiss-Prot Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Enzyme Numbers (IUBMB) for DCK Gene

Gene Ontology (GO) - Molecular Function for DCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004137 deoxycytidine kinase activity IDA 12808445
GO:0005524 ATP binding IEA --
GO:0008144 drug binding IDA 12808445
GO:0019206 nucleoside kinase activity EXP --
GO:0042803 protein homodimerization activity IPI 12808445
genes like me logo Genes that share ontologies with DCK: view
genes like me logo Genes that share phenotypes with DCK: view

Animal Models for DCK Gene

MGI Knock Outs for DCK:
  • Dck tm1.1Radu

miRNA for DCK Gene

miRTarBase miRNAs that target DCK

No data available for Transcription Factor Targeting and HOMER Transcription for DCK Gene

Localization for DCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCK Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCK Gene COMPARTMENTS Subcellular localization image for DCK gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DCK: view

Pathways for DCK Gene

genes like me logo Genes that share pathways with DCK: view

Gene Ontology (GO) - Biological Process for DCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process --
GO:0006144 purine nucleobase metabolic process TAS --
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006220 pyrimidine nucleotide metabolic process IDA 12808445
GO:0009157 deoxyribonucleoside monophosphate biosynthetic process TAS 1996353
genes like me logo Genes that share ontologies with DCK: view

Compounds for DCK Gene

(6) HMDB Compounds for DCK Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine
  • 1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose
58-61-7
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
dCMP
  • 2'-Deoxycytidine 5'-monophosphate
1032-65-1

(15) Drugbank Compounds for DCK Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2'-Deoxycytidine
951-77-9 target
2'-Deoxycytidine
951-77-9 enzyme
Adenosine-5'-Diphosphate
20398-34-9 target
Adenosine-5'-Diphosphate
20398-34-9 enzyme
Cladribine
  • 2-CdA
4291-63-8 enzyme substrate

(97) Novoseek inferred chemical compound relationships for DCK Gene

Compound -log(P) Hits PubMed IDs
deoxycytidine 99.2 262
deoxynucleoside 94.6 24
2-chlorodeoxyadenosine 91.8 75
ara-ctp 91.3 19
gemcitabine 90 158

(3) PharmGKB related drug/compound annotations for DCK Gene

Drug/compound Annotation
cytarabine CA
gemcitabine CA
idarubicin CA
genes like me logo Genes that share compounds with DCK: view

Transcripts for DCK Gene

Unigene Clusters for DCK Gene

Deoxycytidine kinase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for DCK Gene

GeneLoc Exon Structure for
DCK
ECgene alternative splicing isoforms for
DCK

Expression for DCK Gene

mRNA expression in normal human tissues for DCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCK Gene

SOURCE GeneReport for Unigene cluster for DCK Gene Hs.709

genes like me logo Genes that share expressions with DCK: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCK Gene

Orthologs for DCK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCK 35
  • 99.36 (n)
  • 98.46 (a)
DCK 36
  • 79 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCK 35
  • 92.82 (n)
  • 94.23 (a)
DCK 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCK 35
  • 89.87 (n)
  • 86.92 (a)
DCK 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dck 35
  • 88.33 (n)
  • 93.46 (a)
Dck 16
Dck 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCK 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCK 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dck 35
  • 89.45 (n)
  • 91.89 (a)
chicken
(Gallus gallus)
Aves DCK 35
  • 78.39 (n)
  • 81.82 (a)
DCK 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCK 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6839 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dck.1 35
  • 72.69 (n)
  • 81.54 (a)
Str.15187 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10686 35
zebrafish
(Danio rerio)
Actinopterygii dck 35
  • 66.67 (n)
  • 71.54 (a)
dck 36
  • 70 (a)
OneToOne
Dr.24858 35
fruit fly
(Drosophila melanogaster)
Insecta dnk 36
  • 27 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os05g0430200 35
  • 54.71 (n)
  • 45.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for DCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCK Gene

ENSEMBL:
Gene Tree for DCK (if available)
TreeFam:
Gene Tree for DCK (if available)

Paralogs for DCK Gene

Paralogs for DCK Gene

Selected SIMAP similar genes for DCK Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DCK: view

Variants for DCK Gene

Sequence variations from dbSNP and Humsavar for DCK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs936868 -- 71,026,418(-) AACAA(A/C/G/T)TAGCA intron-variant
rs936869 -- 71,026,319(-) CACAC(A/G)CCAGT intron-variant
rs1385986 -- 71,027,394(-) GAATA(C/T)AGTCA intron-variant
rs1385987 -- 71,010,648(-) attta(C/T)attac intron-variant
rs1486271 -- 71,026,796(-) TTTTT(A/T)AGAAA intron-variant

Relevant External Links for DCK Gene

HapMap Linkage Disequilibrium report
DCK
Human Gene Mutation Database (HGMD)
DCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCK Gene

Disorders for DCK Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for DCK Gene including...

Search for DCK Gene in MalaCards »

(2) University of Copenhagen DISEASES for DCK Gene

(46) Novoseek inferred disease relationships for DCK Gene

Disease -log(P) Hits PubMed IDs
leukemia 61.3 19
leukemia lymphocytic chronic 56.7 8
pancreatic cancer 54.5 23
solid tumor 53.9 10
leukemia hairy cell 51.7 1

Relevant External Links for DCK

Genetic Association Database (GAD)
DCK
Human Genome Epidemiology (HuGE) Navigator
DCK
genes like me logo Genes that share disorders with DCK: view

No data available for UniProtKB/Swiss-Prot for DCK Gene

Publications for DCK Gene

  1. Characterization of human deoxycytidine kinase. Correlation with cDNA sequences. (PMID: 2013338) Eriksson S. … Bohman C. (FEBS Lett. 1991) 3 4 23
  2. Human deoxycytidine kinase is located in the cell nucleus. (PMID: 9342341) Johansson M. … Karlsson A. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  3. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. (PMID: 12808445) Sabini E. … Lavie A. (Nat. Struct. Biol. 2003) 3 4 23
  4. Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. (PMID: 15564883) Shi J.Y. … Chen S.J. (Pharmacogenetics 2004) 3 23 48
  5. Novel deoxycytidine kinase gene polymorphisms: a population screening study in Caucasian healthy volunteers. (PMID: 16799820) Joerger M. … Schellens J.H. (Eur. J. Clin. Pharmacol. 2006) 3 23 48

Products for DCK Gene

  • Addgene plasmids for DCK

Sources for DCK Gene

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