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Aliases for DCK Gene

Aliases for DCK Gene

  • Deoxycytidine Kinase 2 3 5
  • EC 2.7.1.74 4 63
  • EC 2.7.1 63
  • DCK 4

External Ids for DCK Gene

Previous GeneCards Identifiers for DCK Gene

  • GC04P071816
  • GC04P072099
  • GC04P072259
  • GC04P072325
  • GC04P072224
  • GC04P072078
  • GC04P067664

Summaries for DCK Gene

Entrez Gene Summary for DCK Gene

  • Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCK Gene

DCK (Deoxycytidine Kinase) is a Protein Coding gene. Diseases associated with DCK include neurofibrosarcoma and lymphoblastic lymphoma. Among its related pathways are Metabolism and Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include protein homodimerization activity and nucleoside kinase activity. An important paralog of this gene is TK2.

UniProtKB/Swiss-Prot for DCK Gene

  • Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Gene Wiki entry for DCK Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCK Gene

Genomics for DCK Gene

Regulatory Elements for DCK Gene

Promoters for DCK Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCK on UCSC Golden Path with GeneCards custom track

Genomic Location for DCK Gene

Chromosome:
4
Start:
70,992,538 bp from pter
End:
71,030,914 bp from pter
Size:
38,377 bases
Orientation:
Plus strand

Genomic View for DCK Gene

Genes around DCK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCK Gene

Proteins for DCK Gene

  • Protein details for DCK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P27707-DCK_HUMAN
    Recommended name:
    Deoxycytidine kinase
    Protein Accession:
    P27707
    Secondary Accessions:
    • B2R8V6
    • Q5TZY7
    • Q6FI11

    Protein attributes for DCK Gene

    Size:
    260 amino acids
    Molecular mass:
    30519 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DCK Gene

neXtProt entry for DCK Gene

Proteomics data for DCK Gene at MOPED

Selected DME Specific Peptides for DCK Gene

Post-translational modifications for DCK Gene

  • Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1.
  • Ubiquitination at Lys 34, Lys 88, Lys 117, Lys 211, and Lys 254
  • Modification sites at PhosphoSitePlus

Other Protein References for DCK Gene

Antibody Products

Domains & Families for DCK Gene

Protein Domains for DCK Gene

Suggested Antigen Peptide Sequences for DCK Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P27707

UniProtKB/Swiss-Prot:

DCK_HUMAN :
  • Belongs to the DCK/DGK family.
Family:
  • Belongs to the DCK/DGK family.
genes like me logo Genes that share domains with DCK: view

No data available for Gene Families for DCK Gene

Function for DCK Gene

Molecular function for DCK Gene

GENATLAS Biochemistry:
deoxycytidine kinase,pyrimidine salvage pathway
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=6.2 uM for deoxycytidine (dC) {ECO:0000269 PubMed:12808445}; KM=15.5 uM for cytarabine (araC) {ECO:0000269 PubMed:12808445}; KM=22 uM for gemcitabine (dC) {ECO:0000269 PubMed:12808445};
UniProtKB/Swiss-Prot CatalyticActivity:
NTP + deoxycytidine = NDP + dCMP.
UniProtKB/Swiss-Prot Function:
Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Enzyme Numbers (IUBMB) for DCK Gene

genes like me logo Genes that share phenotypes with DCK: view

Animal Models for DCK Gene

MGI Knock Outs for DCK:
  • Dck tm1.1Radu

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCK Gene

Localization for DCK Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCK Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCK Gene COMPARTMENTS Subcellular localization image for DCK gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for DCK Gene

Pathways & Interactions for DCK Gene

genes like me logo Genes that share pathways with DCK: view

Gene Ontology (GO) - Biological Process for DCK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006206 pyrimidine nucleobase metabolic process TAS --
GO:0006220 pyrimidine nucleotide metabolic process IDA 12808445
GO:0009165 nucleotide biosynthetic process IEA --
GO:0016310 phosphorylation IEA --
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with DCK: view

No data available for SIGNOR curated interactions for DCK Gene

Drugs & Compounds for DCK Gene

(61) Drugs for DCK Gene - From: Novoseek, HMDB, DrugBank, FDA Approved Drugs, PharmGKB, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cytarabine Approved, Investigational Pharma Enzyme, substrate 1035
Fludarabine Approved Pharma inhibitor, Target, agonist DNA synthsis inhibitor 1059
Gemcitabine Approved Pharma Enzyme, substrate Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1881
Clofarabine Approved, Investigational Pharma Enzyme, substrate Antimetabolite,inhibit DNA polymerase and ribonucleotide reductase 153
Emtricitabine Approved, Investigational Pharma Enzyme, substrate 394

(51) Additional Compounds for DCK Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
NTP
genes like me logo Genes that share compounds with DCK: view

Transcripts for DCK Gene

Unigene Clusters for DCK Gene

Deoxycytidine kinase:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCK Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
SP1: - -
SP2: -
SP3: -
SP4: - - -

Relevant External Links for DCK Gene

GeneLoc Exon Structure for
DCK
ECgene alternative splicing isoforms for
DCK

Expression for DCK Gene

mRNA expression in normal human tissues for DCK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCK Gene

This gene is overexpressed in Bone (49.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCK Gene



SOURCE GeneReport for Unigene cluster for DCK Gene Hs.709

genes like me logo Genes that share expression patterns with DCK: view

Protein tissue co-expression partners for DCK Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCK Gene

Orthologs for DCK Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCK 36
  • 79 (a)
OneToOne
DCK 35
  • 99.36 (n)
  • 98.46 (a)
cow
(Bos Taurus)
Mammalia DCK 36
  • 94 (a)
OneToOne
DCK 35
  • 92.82 (n)
  • 94.23 (a)
dog
(Canis familiaris)
Mammalia DCK 35
  • 89.87 (n)
  • 86.92 (a)
DCK 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dck 16
Dck 35
  • 88.33 (n)
  • 93.46 (a)
Dck 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCK 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCK 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dck 35
  • 89.45 (n)
  • 91.89 (a)
chicken
(Gallus gallus)
Aves DCK 35
  • 78.39 (n)
  • 81.82 (a)
DCK 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCK 36
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6839 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dck.1 35
  • 72.69 (n)
  • 81.54 (a)
Str.15187 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10686 35
zebrafish
(Danio rerio)
Actinopterygii dck 36
  • 70 (a)
OneToOne
dck 35
  • 66.67 (n)
  • 71.54 (a)
Dr.24858 35
fruit fly
(Drosophila melanogaster)
Insecta dnk 36
  • 27 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os05g0430200 35
  • 54.71 (n)
  • 45.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for DCK:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCK Gene

ENSEMBL:
Gene Tree for DCK (if available)
TreeFam:
Gene Tree for DCK (if available)

Paralogs for DCK Gene

Paralogs for DCK Gene

(7) SIMAP similar genes for DCK Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DCK: view

Variants for DCK Gene

Sequence variations from dbSNP and Humsavar for DCK Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs936868 -- 71,026,418(-) AACAA(A/C/G/T)TAGCA intron-variant
rs936869 -- 71,026,319(-) CACAC(A/G)CCAGT intron-variant
rs1580469 -- 70,998,362(-) CAATC(C/T)GAAAC intron-variant
rs1906021 -- 70,992,507(-) TGGTC(A/G)CAGGC upstream-variant-2KB
rs1803484 -- 71,030,626(+) ATTAA(A/G)TATTT utr-variant-3-prime

Variation tolerance for DCK Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCK Gene

HapMap Linkage Disequilibrium report
DCK
Human Gene Mutation Database (HGMD)
DCK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCK Gene

Disorders for DCK Gene

MalaCards: The human disease database

(10) MalaCards diseases for DCK Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
neurofibrosarcoma
  • neurosarcoma [obs]
lymphoblastic lymphoma
  • lymphoma, lymphoblastic
uterine sarcoma
  • uterine corpus sarcoma
periampullary adenocarcinoma
pancreatic cancer
  • pancreatic carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards
Search DCK in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCK

Genetic Association Database (GAD)
DCK
Human Genome Epidemiology (HuGE) Navigator
DCK
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCK
genes like me logo Genes that share disorders with DCK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCK Gene

Publications for DCK Gene

  1. [Correlation of deoxycytidine kinase gene expression with fludarabine resistance in patients with chronic lymphocytic leukemia]. (PMID: 20137114) Yao L. … Li J.Y. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2010) 3 23 25 26
  2. Twenty novel genetic variations and haplotype structures of the DCK gene encoding human deoxycytidine kinase (dCK). (PMID: 18974616) Kim S.R. … Sawada J. (Drug Metab. Pharmacokinet. 2008) 3 23 48 67
  3. Optimizing pemetrexed-gemcitabine combination in patients with advanced non-small cell lung cancer: a pharmacogenetic approach. (PMID: 21336182) De Pas T.M. … De Braud F. (J Thorac Oncol 2011) 3 25 26
  4. Genetic factors influencing cytarabine therapy. (PMID: 19842938) Lamba J.K. (Pharmacogenomics 2009) 23 25 26
  5. In vitro interactions between apricitabine and other deoxycytidine analogues. (PMID: 17517847) Bethell R. … Collins P. (Antimicrob. Agents Chemother. 2007) 23 25 26

Products for DCK Gene

Sources for DCK Gene

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