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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DCK Gene

protein-coding GIFtS: 68
GCID: GC04P071816

deoxycytidine kinase

Explore 45 diseases affiliated with
DCK via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Deoxycytidine Kinase¹ ²
EC 2.7.1.74³ ⁸
Deoxynucleoside Kinase²
DCK¹
EC 2.7.1⁸

External Ids:	HGNC: 2704¹	Entrez Gene: 1633²	Ensembl: ENSG00000156136⁷	OMIM: 125450⁵	UniProtKB: P27707³

Export aliases for DCK gene to outside databases

Previous GC identifers: GC04P072099 GC04P072259 GC04P072325 GC04P072224 GC04P072078 GC04P067664

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCK:

Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside

analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.

Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to

cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug

resistance and sensitivity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DCK_HUMAN, P27707

Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and

deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the

substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as

antiviral and chemotherapeutic agents

Gene Wiki entry for DCK (Deoxycytidine kinase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000004.11 NC_018915.1 NT_022778.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DCK gene promoter:
STAT5B AML1a p53 POU3F1 CUTL1 HNF-3beta POU2F1 HFH-1 POU2F1a ZIC2/Zic2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DCK promoter sequence

Search SABiosciences Chromatin IP Primers for DCK

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCK

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3-q21.1 Ensembl cytogenetic band: 4q13.3 HGNC cytogenetic band: 4q13.3-q21.1

DCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCK gene location

GeneLoc information about chromosome 4 GeneLoc Exon Structure

GeneLoc location for GC04P071816: view genomic region (about GC identifiers)

Start:	71,858,255 bp from pter	End:	71,896,631 bp from pter
Size:	38,377 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DCK_HUMAN, P27707 (See protein sequence)

Recommended Name: Deoxycytidine kinase

Size: 260 amino acids; 30519 Da

Subunit: Homodimer

Subcellular location: Nucleus

Caution: Was shown to be phosphorylated and activated by CSNK1D/CK1 in vitro but probably not in vivo (PubMed:20637175)

6/30 PDB 3D structures from and Proteopedia for DCK (see all 30):

1P5Z (3D)

1P60 (3D)

1P61 (3D)

1P62 (3D)

2A2Z (3D)

2A30 (3D)

Secondary accessions: B2R8V6 Q5TZY7 Q6FI11

Explore the universe of human proteins at neXtProt for DCK: NX_P27707

Post-translational modifications:

Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK1¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P27707

3 DME Specific Peptides for DCK (P27707)

KKISIEGNI

FERSVYSDRYIFA

EDWEVVPEPVARWCNVQSTQ

DCK Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000779.1

ENSEMBL proteins:

ENSP00000422971 ENSP00000286648 ENSP00000426389 ENSP00000425578 ENSP00000421508

Reactome Protein details: P27707
Human Recombinant Protein Products for DCK:

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	Novus Biologicals DCK Proteins Novus Biologicals DCK Lysates
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	ProSpec Recombinant Protein for DCK
	Uscn Proteins for DCK

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005829	cytosol	TAS	--

DCK for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for DCK

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DCK for domains About GeneDecksing

1 InterPro domain/family:

IPR002624 Deoxynucleoside_kinase

Graphical View of Domain Structure for InterPro Entry P27707

ProtoNet protein and cluster: P27707

1 Blocks protein family: IPB002624 Deoxynucleoside kinase

UniProtKB/Swiss-Prot: DCK_HUMAN, P27707

Similarity: Belongs to the DCK/DGK family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DCK_HUMAN, P27707

Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and

deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the

substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as

antiviral and chemotherapeutic agents

Catalytic activity: NTP + deoxycytidine = NDP + dCMP

Biophysicochemical properties: Kinetic parameters: KM=6.2 uM for deoxycytidine (dC); KM=15.5 uM for cytarabine (araC);

KM=22 uM for gemcitabine (dC);

Genatlas biochemistry entry for DCK:

deoxycytidine kinase,pyrimidine salvage pathway

Enzyme Numbers (IUBMB): EC 2.7.1.74¹ ² EC 2.7.1²

Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000287	magnesium ion binding	--	--
GO:0004137	deoxycytidine kinase activity	IDA	12808445
GO:0005524	ATP binding	IEA	--
GO:0008144	drug binding	IDA	12808445
GO:0016773	phosphotransferase activity, alcohol group as acceptor	IEA	--

DCK for ontologies About GeneDecksing

Phenotypes:
5 GenomeRNAi human phenotypes for DCK:

Decreased 12E8 and total tau p	Decreased telomerase activity	Gemcitabine induced cell-death	Increased cell death HMECs cel
Increased gamma-H2AX phosphory

4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dck):

cellular

hematopoietic system

immune system

normal

DCK for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Dck^tm1.1Radu for DCK

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DCK

miRNA Products:		OriGene 3'-UTR Clone: DCK Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCK
		8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DCK (see all 13):
		hsa-miR-411* hsa-miR-3164 hsa-miR-361-5p hsa-miR-548am hsa-miR-379* hsa-miR-148b hsa-miR-3065-5p hsa-miR-500a

		SwitchGear 3'UTR luciferase reporter plasmid: DCK 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCK (see all 7) OriGene shRNA RFP: DCK OriGene siRNA: DCK
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DCK
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCK

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Purine metabolism

	Purine metabolism	1.00			Purine salvage	0.39
	Metabolism of nucleotides	0.42

Pyrimidine metabolism

Pyrimidine metabolism

1.00

Pyrimidine salvage reactions

0.38

Metabolism

Metabolism

1.00

Metabolic pathways

0.38

Purine metabolism

Purine metabolism

1.00

Pyrimidine metabolism

0.38

Gemcitabine Pathway, Pharmacodynamics

Gemcitabine Pathway, Pharmacodynamics

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/6 Reactome Pathways for DCK (see all 6)

	Metabolism of nucleotides
	Metabolism
	Purine salvage
	Purine metabolism
	Pyrimidine salvage reactions

2 PharmGKB Pathways for DCK

	Gemcitabine Pathway, Pharmacodynamics
	Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics

3 Kegg Pathways (Kegg details for DCK):

	Purine metabolism
	Pyrimidine metabolism
	Metabolic pathways

DCK for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DCK

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/51 Interacting proteins for DCK (P27707^{2, 3} ENSP00000286648⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 51)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GOLM1	Q8NBJ4²^,³	MINT-64962 I2D: score=5
MED19	A0JLT2²^,³	MINT-64896 I2D: score=5
RXRG	P48443²^,³, ENSP00000352900⁴	MINT-8254089 I2D: score=2 STRING: ENSP00000352900
DDX19B	Q9UMR2³	I2D: score=4
DCK	P27707²	MINT-8254078

About this table

Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006139	nucleobase-containing compound metabolic process	--	--
GO:0006144	purine nucleobase metabolic process	TAS	--
GO:0006206	pyrimidine nucleobase metabolic process	TAS	--
GO:0006220	pyrimidine nucleotide metabolic process	IDA	12808445
GO:0009165	nucleotide biosynthetic process	EXP	--

DCK for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DCK for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DCK

6 HMDB Compounds for DCK About this table

Compound	Synonyms	CAS #	PubMed Ids
Deoxycytidine	1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)	951-77-9	17296311
ADP	adenosindiphosphorsaeure (see all 8)	58-64-0	--
Adenosine	1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)	58-61-7	--
Adenosine monophosphate	5'-AMP (see all 28)	61-19-8	--
Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine (see all 24)	56-65-5	--
dCMP	2'-Deoxycytidine 5'-monophosphate (see all 12)	1032-65-1	--

10/12 DrugBank Compounds for DCK (see all 12) About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Cladribine	2-CdA (see all 5)	4291-63-8	enzyme	substrate	19463072 19576186 19715446 20634380 20689698 17852710
Nelarabine	GW-506U78 (see all 2)	121032-29-9	enzyme	substrate	17344466 20616909 18516261 18035189 19825456
Clofarabine	--	123318-82-1	enzyme	substrate	19576186 20631817 17852710
Fludarabine	FAMP (see all 4)	75607-67-9	target	agonist	15820918 16421443 20137114
Cytarabine	Ara-C (see all 26)	147-94-4	enzyme	substrate	19842938 15492802
Gemcitabine	--	95058-81-4	enzyme	substrate	19514966 20669326
Zalcitabine	DDC (see all 3)	7481-89-2	enzyme	substrate	7763311 10585881
Decitabine	5-aza-2'-deoxycytidine (see all 3)	2353-33-5	enzyme	--	21127859
Emtricitabine	--	143491-57-0	enzyme	substrate	17517847
Pemetrexed	LY231514 (see all 2)	150399-23-8	enzyme	inducer	21336182

10/97 Novoseek chemical compound relationships for DCK gene (see all 97) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
deoxycytidine	99.2	1059	8356916 (7), 9345319 (5), 7980770 (5), 9342341 (5) (see all 99)
deoxynucleoside	94.6	40	11440177 (2), 12535661 (1), 15104248 (1), 11000580 (1) (see all 23)
2-chlorodeoxyadenosine	91.8	133	8094016 (6), 7718326 (4), 9802328 (4), 9776315 (4) (see all 48)
ara-ctp	91.3	22	7475275 (3), 19428333 (3), 2249330 (1), 7654012 (1) (see all 15)
gemcitabine	90	298	12477049 (8), 16638857 (7), 15471562 (6), 11595723 (5) (see all 88)
nucleoside	89.8	166	18377927 (4), 8625309 (3), 15950950 (3), 9598144 (3) (see all 78)
deoxyguanosine	89.7	104	8962060 (4), 10575360 (3), 17897085 (3), 9593124 (3) (see all 50)
cdamp	89.6	4	9533533 (1), 15135110 (1), 17065053 (1)
cytarabine	89.5	156	11830489 (7), 10995016 (4), 12406011 (3), 10942400 (3) (see all 64)
dctp	87.5	22	1406603 (2), 8962060 (2), 1917159 (1), 9215860 (1) (see all 16)

Search CenterWatch for drugs/clinical trials and news about DCK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DCK gene:

NM_000788.2

Unigene Cluster for DCK:

Deoxycytidine kinase

Hs.709 [show with all ESTs]

Unigene Representative Sequence: CD014015

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000509617 ENST00000286648(uc003hfx.3) ENST00000503359(uc011cbb.2)

ENST00000504730 ENST00000504952 ENST00000509764

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		hsa-miR-411* hsa-miR-3164 hsa-miR-361-5p hsa-miR-548am hsa-miR-379* hsa-miR-148b hsa-miR-3065-5p hsa-miR-500a

		SwitchGear 3'UTR luciferase reporter plasmid: DCK 3' UTR sequence

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		GenScript: all cDNA clones in your preferred vector: DCK (NM_000788)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCK

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCK
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCK

Additional cDNA sequence:

AK303292.1 AK313523.1 BC103764.1 BC114617.1 BT019941.1 BT019942.1 CR536527.1 CR541876.1

JF806429.1 M60527.1

6 DOTS entries:

DT.214721 DT.100649306 DT.99994300 DT.101981862 DT.91750417 DT.100720128

24/143 AceView cDNA sequences (see all 143):

CR541876 BQ083320 BQ221914 BG779403 AW161391 CK904730 CD014015 BG149683

BQ220213 CR536527 BG389564 CD014016 CA310016 BM720582 BQ069129 BM918952

BQ879026 BM987644 AU154063 CK904729 BQ420469 CD014014 AI275599 BI601939

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DCK About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8
SP1:			-												-
SP2:			-
SP3:															-
SP4:			-								-				-

ECgene alternative splicing isoforms for DCK

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DCK expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTCAAAAAA

About this image

DCK expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Lung

Lung Bud

Lung

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DCK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCK

SOURCE GeneReport for Unigene cluster: Hs.709

SABiosciences Custom PCR Arrays for DCK

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCK Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCK

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCK

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCK gene from 7/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dck^{1 , 5}	deoxycytidine kinase^{1, 5}	88.33(n)¹ 93.46(a)¹		5 (43.96 cM)⁵ 13178¹ NM_007832.4¹ NP_031858.1¹ 88764996⁵
chicken (Gallus gallus)	Aves	DCK¹	deoxycytidine kinase	78.39(n) 81.82(a)		422648 NM_001006451.1 NP_001006451.1
lizard (Anolis carolinensis)	Reptilia	DCK⁶	--	80(a)	1 ↔ 1	5(147222016-147233290)
African clawed frog (Xenopus laevis)	Amphibia	Xl.6839²	Xenopus laevis transcribed sequence with moderate similarity more	78.71(n)		CA981505.1
zebrafish (Danio rerio)	Actinopterygii	Dr.24858²	Transcribed sequence with weak similarity to protein more	73.91(n)		57071408
thale cress (Arabidopsis thaliana)	eudicotyledons	AT1G72040⁶	P-loop containing nucleoside triphosphate hydrolas...	15(a)	1 → many	1(27111894-27114342)
rice (Oryza sativa)	Liliopsida	Os05g0430200¹	hypothetical protein	54.89(n) 45.65(a)		4338875 NM_001062157.1 NP_001055622.1

ENSEMBL Gene Tree for DCK (if available)
TreeFam Gene Tree for DCK (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DCK gene

TK2² DGUOK²

7 SIMAP similar genes for DCK using alignment to 5 protein entries: DCK_HUMAN (see all proteins):

SPATS2L ZNF212 ZNF564 NF2 DNAPTP3 DGUOK

TK2

DCK for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 4 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs139006020^1,2		--	71857294(+)	`GAACTA/GGTGTT`	1	--	us2k¹		0	--	--	--	--
rs185137408^1,2		--	71857300(+)	`GTGTTC/TGAAAT`	1	--	us2k¹		0	--	--	--	--
rs76459895^1,2		--	71857338(+)	`CATCAC/TTGTAA`	1	--	us2k¹		0	--	--	--	--
rs182648130^1,2		--	71857379(+)	`AACCAC/TACTTG`	1	--	us2k¹		0	--	--	--	--
rs118162067^1,2		--	71857406(+)	`AACCCC/TAAGCC`	1	--	us2k¹		1		EA	120
rs75860698^1,2	C	--	71857438(+)	`ACCAGC/TTCTGC`	1	--	us2k¹		2		CSA WA	120
rs72646434^1,2	C,F	--	71857610(+)	`TCTTCA/GGGCCT`	1	--	us2k¹		1		NA	120
rs72854163^1,2	C	--	71857627(+)	`TTCCTA/CGGATC`	1	--	us2k¹		2		WA	120
rs76567224^1,2	C,F	--	71857780(+)	`CTGCTC/GTTTAT`	1	--	us2k¹		1		NA	120
rs149732069^1,2		--	71857820(+)	`TCTGG-/CTACAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DCK (71858255 - 71896631 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DCK: --
Human Gene Mutation Database (HGMD): DCK

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCK

DNA2.0 Custom Variant and Variant Library Synthesis for DCK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DCK for disorders           About GeneDecksing

OMIM gene information: 125450    OMIM disorders: --

20/45 diseases for DCK (see all 45):    About MalaCards

purine nucleoside phosphorylase deficiency nucleoside phosphorylase deficiency mitochondrial dna depletion myopathy adenosine deaminase deficiency

herpes simplex neurofibrosarcoma lymphoblastic leukemia lymphocytic leukemia

leukemia uterine sarcoma papillary thyroid carcinoma acute lymphoblastic leukemia

leiomyosarcoma chronic lymphocytic leukemia acute myeloid leukemia myeloid leukemia

follicular lymphoma carcinoma acute leukemia adenocarcinoma

1 disease from the University of Copenhagen DISEASES database for DCK:

Leukemia

10/46 Novoseek disease relationships for DCK gene (see all 46) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	61.3	29	19099730 (2), 11896543 (2), 10961690 (1), 15037202 (1) (see all 17)
leukemia lymphocytic chronic	56.7	13	12566084 (2), 11275369 (1), 20137114 (1), 7942271 (1) (see all 7)
pancreatic cancer	54.5	32	18751396 (5), 19487279 (3), 16638857 (3), 20043109 (3) (see all 11)
solid tumor	53.9	16	10961690 (3), 15276067 (2), 12477049 (1), 12604712 (1) (see all 7)
leukemia hairy cell	51.7	1	7942271 (1)
lymphocytic leukemia chronic b-cell	43.6	5	15202025 (1), 7942271 (1), 16778146 (1)
nsclc	42.1	26	15471562 (4), 19500405 (2), 20211060 (2), 20436341 (2) (see all 7)
acute leukemia	37.3	3	15571257 (1), 19099730 (1)
hematologic malignancies	36.5	5	19099730 (2), 11896543 (1)
aml adult	32	1	12628850 (1)

Genetic Association Database (GAD): DCK
Human Genome Epidemiology (HuGE) Navigator: DCK (12 documents)

Export disorders for DCK gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DCK gene, integrated from 9 sources (see all 455):
(articles sorted by number of sources associating them with DCK)

Utopia: connect your pdf to the dynamic
world of online information

Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. (PubMed id 19159229)^{1, 2, 9} Hazra S....Lavie A. (2009)
The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. (PubMed id 16421443)^{2, 7, 9} Zhang Y....Ealick S.E. (2006)
[Correlation of deoxycytidine kinase gene expression with fludarabine resistance in patients with chronic lymphocytic leukemia] (PubMed id 20137114)^{1, 7, 9} Yao L....Li J.Y. (2010)
Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. (PubMed id 15564883)^{1, 4, 9} Shi J.Y....Chen S.J. (2004)
Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. (PubMed id 12808445)^{1, 2, 9} Sabini E.... Lavie A. (2003)
Characterization of human deoxycytidine kinase. Correlation with cDNA sequences. (PubMed id 2013338)^{1, 2, 9} Eriksson S.... Bohman C. (1991)
Human deoxycytidine kinase is located in the cell nucleus. (PubMed id 9342341)^{1, 2, 9} Johansson M.... Karlsson A. (1997)
Optimizing pemetrexed-gemcitabine combination in pati ents with advanced non-small cell lung cancer: a pharmacogenetic approach. (PubMed id 21336182)^{1, 7} De Pas T.M....De Braud F. (2011)
Casein kinase 1delta activates human recombinant deox ycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. (PubMed id 20637175)^{1, 2} Smal C....Bontemps F. (2010)
Structural and kinetic characterization of human deox ycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . (PubMed id 20614893)^{1, 2} Hazra S....Lavie A. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1633	HGNC: 2704	AceView: DCK	Ensembl:ENSG00000156136	euGenes: HUgn1633
ECgene: DCK	Kegg: 1633	H-InvDB: DCK

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DCK	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DCK	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DCK gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DCK gene:
Search GeneIP for patents involving DCK

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

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deoxycytidine kinase

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