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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCK Gene

protein-coding   GIFtS: 68
GCID: GC04P071816

deoxycytidine kinase
 Explore 45 diseases affiliated with
DCK via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DCK    

Aliases
for DCK gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Deoxycytidine Kinase1 2
EC 2.7.1.743 8
Deoxynucleoside Kinase2
DCK1
EC 2.7.18

External Ids:    HGNC: 27041   Entrez Gene: 16332   Ensembl: ENSG000001561367   OMIM: 1254505   UniProtKB: P277073   

Export aliases for DCK gene to outside databases

Previous GC identifers: GC04P072099 GC04P072259 GC04P072325 GC04P072224 GC04P072078 GC04P067664


Summaries
for DCK gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DCK:
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside
analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.
Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to
cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug
resistance and sensitivity. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DCK_HUMAN, P27707
Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and
deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the
substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as
antiviral and chemotherapeutic agents

Gene Wiki entry for DCK (Deoxycytidine kinase)


Genomic Views
for DCK gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DCK gene promoter:
         STAT5B   AML1a   p53   POU3F1   CUTL1   HNF-3beta   POU2F1   HFH-1   POU2F1a   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DCK promoter sequence
   Search SABiosciences Chromatin IP Primers for DCK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.3-q21.1   Ensembl cytogenetic band:  4q13.3   HGNC cytogenetic band: 4q13.3-q21.1

DCK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCK gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P071816:  view genomic region     (about GC identifiers)

Start:
 71,858,255 bp from pter      End:
 71,896,631 bp from pter
Size:
 38,377 bases      Orientation:
 plus strand

Proteins
for DCK gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DCK_HUMAN, P27707 (See protein sequence)
Recommended Name: Deoxycytidine kinase  
Size: 260 amino acids; 30519 Da
Subunit: Homodimer
Subcellular location: Nucleus
Caution: Was shown to be phosphorylated and activated by CSNK1D/CK1 in vitro but probably not in vivo (PubMed:20637175)
6/30 PDB 3D structures from and Proteopedia for DCK (see all 30):
1P5Z (3D)        1P60 (3D)        1P61 (3D)        1P62 (3D)        2A2Z (3D)        2A30 (3D)    
Secondary accessions: B2R8V6 Q5TZY7 Q6FI11

Explore the universe of human proteins at neXtProt for DCK: NX_P27707

Post-translational modifications:

  • Phosphorylated and activated in vitro upon phosphorylation at Ser-74 by CSNK1D/CK11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P27707

    • 3 DME Specific Peptides for DCK (P27707)
     KKISIEGNI  FERSVYSDRYIFA  EDWEVVPEPVARWCNVQSTQ 

    DCK Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_000779.1  
    ENSEMBL proteins: 
     ENSP00000422971   ENSP00000286648   ENSP00000426389   ENSP00000425578   ENSP00000421508  
    Reactome Protein details: P27707
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Proteins (see all 3): DCK
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    Novus Biologicals DCK Proteins
    Novus Biologicals DCK Lysates
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    ProSpec Recombinant Protein for DCK
    Uscn Proteins for DCK

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005829cytosol TAS--


    DCK for ontologies           About GeneDecksing



    DCK Antibody Products: 
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    ThermoFisher Antibody for DCK

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    Uscn ELISAs and CLIAs for DCK

    Protein Domains /
    Families
    for DCK gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DCK for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002624 Deoxynucleoside_kinase

    Graphical View of Domain Structure for InterPro Entry P27707

    ProtoNet protein and cluster: P27707

    1 Blocks protein family: IPB002624 Deoxynucleoside kinase

    UniProtKB/Swiss-Prot: DCK_HUMAN, P27707
    Similarity: Belongs to the DCK/DGK family


    Function
    for DCK gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DCK_HUMAN, P27707
    Function: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and
    deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the
    substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as
    antiviral and chemotherapeutic agents
    Catalytic activity: NTP + deoxycytidine = NDP + dCMP
    Biophysicochemical properties: Kinetic parameters: KM=6.2 uM for deoxycytidine (dC); KM=15.5 uM for cytarabine (araC);
    KM=22 uM for gemcitabine (dC);

         Genatlas biochemistry entry for DCK:
    deoxycytidine kinase,pyrimidine salvage pathway

    Enzyme Numbers (IUBMB): EC 2.7.1.741 2 EC 2.7.12

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DCK
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DCK
    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DCK (see all 13):
    hsa-miR-411* hsa-miR-3164 hsa-miR-361-5p hsa-miR-548am hsa-miR-379* hsa-miR-148b hsa-miR-3065-5p hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmid: DCK 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCK (see all 7)
    OriGene shRNA RFP: DCK
    OriGene siRNA: DCK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCK

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DCK

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCK (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCK (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DCK (NM_000788)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCK
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCK 

    Cell Line
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    Search LifeMap BioReagents cell lines for DCK

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCK

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding ----
    GO:0004137deoxycytidine kinase activity IDA12808445
    GO:0005524ATP binding IEA--
    GO:0008144drug binding IDA12808445
    GO:0016773phosphotransferase activity, alcohol group as acceptor IEA--


    DCK for ontologies           About GeneDecksing


    5 GenomeRNAi human phenotypes for DCK:
     Decreased 12E8 and total tau p  Decreased telomerase activity  Gemcitabine induced cell-death  Increased cell death HMECs cel 
     Increased gamma-H2AX phosphory 

    Animal Models:
         Mouse knock-out Dcktm1.1Radu for DCK
         4 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dck):
     cellular  hematopoietic system  immune system  normal 

    DCK for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DCK gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Purine metabolism
    		Purine metabolism1.00
    		Purine salvage0.39
    		Metabolism of nucleotides0.42
    2Pyrimidine metabolism
    		Pyrimidine metabolism1.00
    		Pyrimidine salvage reactions0.38
    3Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    4Purine metabolism
    		Purine metabolism1.00
    		Pyrimidine metabolism0.38
    5Gemcitabine Pathway, Pharmacodynamics
    		Gemcitabine Pathway, Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/6        Reactome Pathways for DCK (see all 6)
        Metabolism of nucleotides
    Metabolism
    Purine salvage
    Purine metabolism
    Pyrimidine salvage reactions

    2 PharmGKB Pathways for DCK
        Gemcitabine Pathway, Pharmacodynamics
    Lamivudine Pathway, Pharmacokinetics/Pharmacodynamics

    3         Kegg Pathways  (Kegg details for DCK):
        Purine metabolism
    Pyrimidine metabolism
    Metabolic pathways


    DCK for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DCK

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/51 Interacting proteins for DCK (P277072, 3 ENSP000002866484) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLM1Q8NBJ42, 3MINT-64962 I2D: score=5 
    MED19A0JLT22, 3MINT-64896 I2D: score=5 
    RXRGP484432, 3, ENSP000003529004MINT-8254089 I2D: score=2 STRING: ENSP00000352900
    DDX19BQ9UMR23I2D: score=4 
    DCKP277072MINT-8254078
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006139nucleobase-containing compound metabolic process ----
    GO:0006144purine nucleobase metabolic process TAS--
    GO:0006206pyrimidine nucleobase metabolic process TAS--
    GO:0006220pyrimidine nucleotide metabolic process IDA12808445
    GO:0009165nucleotide biosynthetic process EXP--


    DCK for ontologies           About GeneDecksing



    Drugs & Compounds
    for DCK gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DCK for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCK

    6 HMDB Compounds for DCK    About this table
    CompoundSynonyms CAS #PubMed Ids
    Deoxycytidine1-(2-Deoxy-b-D-ribofuranosyl)cytosine (see all 15)951-77-917296311
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine1-(6-amino-9H-purin-9-yl)-1-deoxy-beta-D-Ribofuranose (see all 32)58-61-7--
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    dCMP2'-Deoxycytidine 5'-monophosphate (see all 12)1032-65-1--

    10/12 DrugBank Compounds for DCK (see all 12)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Cladribine2-CdA (see all 5)4291-63-8enzymesubstrate19463072 19576186 19715446 20634380 20689698 17852710
    NelarabineGW-506U78 (see all 2)121032-29-9enzymesubstrate17344466 20616909 18516261 18035189 19825456
    Clofarabine-- 123318-82-1enzymesubstrate19576186 20631817 17852710
    FludarabineFAMP (see all 4)75607-67-9targetagonist15820918 16421443 20137114
    CytarabineAra-C (see all 26)147-94-4enzymesubstrate19842938 15492802
    Gemcitabine-- 95058-81-4enzymesubstrate19514966 20669326
    ZalcitabineDDC (see all 3)7481-89-2enzymesubstrate7763311 10585881
    Decitabine5-aza-2'-deoxycytidine (see all 3)2353-33-5enzyme--21127859
    Emtricitabine-- 143491-57-0enzymesubstrate17517847
    PemetrexedLY231514 (see all 2)150399-23-8enzymeinducer21336182

    10/97 Novoseek chemical compound relationships for DCK gene (see all 97)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    deoxycytidine 99.2 1059 8356916 (7), 9345319 (5), 7980770 (5), 9342341 (5) (see all 99)
    deoxynucleoside 94.6 40 11440177 (2), 12535661 (1), 15104248 (1), 11000580 (1) (see all 23)
    2-chlorodeoxyadenosine 91.8 133 8094016 (6), 7718326 (4), 9802328 (4), 9776315 (4) (see all 48)
    ara-ctp 91.3 22 7475275 (3), 19428333 (3), 2249330 (1), 7654012 (1) (see all 15)
    gemcitabine 90 298 12477049 (8), 16638857 (7), 15471562 (6), 11595723 (5) (see all 88)
    nucleoside 89.8 166 18377927 (4), 8625309 (3), 15950950 (3), 9598144 (3) (see all 78)
    deoxyguanosine 89.7 104 8962060 (4), 10575360 (3), 17897085 (3), 9593124 (3) (see all 50)
    cdamp 89.6 4 9533533 (1), 15135110 (1), 17065053 (1)
    cytarabine 89.5 156 11830489 (7), 10995016 (4), 12406011 (3), 10942400 (3) (see all 64)
    dctp 87.5 22 1406603 (2), 8962060 (2), 1917159 (1), 9215860 (1) (see all 16)

    Search CenterWatch for drugs/clinical trials and news about DCK 

    Transcripts
    for DCK gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DCK gene: 
    NM_000788.2  

    Unigene Cluster for DCK:

    Deoxycytidine kinase
    Hs.709  [show with all ESTs]
    Unigene Representative Sequence: CD014015
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000509617 ENST00000286648(uc003hfx.3) ENST00000503359(uc011cbb.2)
    ENST00000504730 ENST00000504952 ENST00000509764

    miRNA
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    8/13 QIAGEN miScript miRNA Assays for microRNAs that regulate DCK (see all 13):
    hsa-miR-411* hsa-miR-3164 hsa-miR-361-5p hsa-miR-548am hsa-miR-379* hsa-miR-148b hsa-miR-3065-5p hsa-miR-500a
    SwitchGear 3'UTR luciferase reporter plasmid: DCK 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCK (see all 7)
    OriGene shRNA RFP: DCK
    OriGene siRNA: DCK
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCK
    Clone
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    GenScript: all cDNA clones in your preferred vector: DCK (NM_000788)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCK

    Additional cDNA sequence: 

    AK303292.1 AK313523.1 BC103764.1 BC114617.1 BT019941.1 BT019942.1 CR536527.1 CR541876.1 
    JF806429.1 M60527.1 

    6 DOTS entries:

    DT.214721  DT.100649306  DT.99994300  DT.101981862  DT.91750417  DT.100720128 

    24/143 AceView cDNA sequences (see all 143):

    CR541876 BQ083320 BQ221914 BG779403 AW161391 CK904730 CD014015 BG149683 
    BQ220213 CR536527 BG389564 CD014016 CA310016 BM720582 BQ069129 BM918952 
    BQ879026 BM987644 AU154063 CK904729 BQ420469 CD014014 AI275599 BI601939 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DCK    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8
    SP1:        -                                   -         
    SP2:        -                                             
    SP3:                                            -         
    SP4:        -                       -           -         


    ECgene alternative splicing isoforms for DCK

    Expression
    for DCK gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ACTCAAAAAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DCK expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DCK Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCK

    SOURCE GeneReport for Unigene cluster: Hs.709
        SABiosciences Custom PCR Arrays for DCK
    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCK
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCK

    Orthologs
    for DCK gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCK gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dck1 , 5 deoxycytidine kinase1, 5 88.33(n)1
    93.46(a)1    		   5 (43.96 cM)5
    131781  NM_007832.41  NP_031858.11 
     887649965 
    chicken
    (Gallus gallus)    		 Aves DCK1 deoxycytidine kinase 78.39(n)
    81.82(a)    		   422648  NM_001006451.1  NP_001006451.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DCK6
    		 --
    		 80(a)
    		 1 ↔ 1
    		 5(147222016-147233290)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.68392 Xenopus laevis transcribed sequence with moderate similarity more 78.71(n)    CA981505.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.248582 Transcribed sequence with weak similarity to protein more 73.91(n)    57071408 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G720406
    		 P-loop containing nucleoside triphosphate hydrolas...
    		 15(a)
    		 1 → many
    		 1(27111894-27114342)
    rice
    (Oryza sativa)    		 Liliopsida Os05g04302001 hypothetical protein 54.89(n)
    45.65(a)    		   4338875  NM_001062157.1  NP_001055622.1 


    ENSEMBL Gene Tree for DCK (if available)
    TreeFam Gene Tree for DCK (if available) 

    Paralogs
    for DCK gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCK gene
    TK22  DGUOK2  
    7 SIMAP similar genes for DCK using alignment to 5 protein entries:     DCK_HUMAN (see all proteins):
    SPATS2L    ZNF212    ZNF564    NF2    DNAPTP3    DGUOK
    TK2

    DCK for paralogs           About GeneDecksing



    Genomic Variants
    for DCK gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Human Gene Mutation Database (HGMD): DCK
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCK
    DNA2.0 Custom Variant and Variant Library Synthesis for DCK

    Disorders / Diseases
    for DCK gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DCK for disorders           About GeneDecksing

    OMIM gene information: 125450    OMIM disorders: --

    20/45 diseases for DCK (see all 45):    About MalaCards
    purine nucleoside phosphorylase deficiency    nucleoside phosphorylase deficiency    mitochondrial dna depletion myopathy    adenosine deaminase deficiency
    herpes simplex    neurofibrosarcoma    lymphoblastic leukemia    lymphocytic leukemia
    leukemia    uterine sarcoma    papillary thyroid carcinoma    acute lymphoblastic leukemia
    leiomyosarcoma    chronic lymphocytic leukemia    acute myeloid leukemia    myeloid leukemia
    follicular lymphoma    carcinoma    acute leukemia    adenocarcinoma

    1 disease from the University of Copenhagen DISEASES database for DCK:
    Leukemia

    10/46 Novoseek disease relationships for DCK gene (see all 46)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 61.3 29 19099730 (2), 11896543 (2), 10961690 (1), 15037202 (1) (see all 17)
    leukemia lymphocytic chronic 56.7 13 12566084 (2), 11275369 (1), 20137114 (1), 7942271 (1) (see all 7)
    pancreatic cancer 54.5 32 18751396 (5), 19487279 (3), 16638857 (3), 20043109 (3) (see all 11)
    solid tumor 53.9 16 10961690 (3), 15276067 (2), 12477049 (1), 12604712 (1) (see all 7)
    leukemia hairy cell 51.7 1 7942271 (1)
    lymphocytic leukemia chronic b-cell 43.6 5 15202025 (1), 7942271 (1), 16778146 (1)
    nsclc 42.1 26 15471562 (4), 19500405 (2), 20211060 (2), 20436341 (2) (see all 7)
    acute leukemia 37.3 3 15571257 (1), 19099730 (1)
    hematologic malignancies 36.5 5 19099730 (2), 11896543 (1)
    aml adult 32 1 12628850 (1)

    Genetic Association Database (GAD): DCK
    Human Genome Epidemiology (HuGE) Navigator: DCK (12 documents)

    Export disorders for DCK gene to outside databases

    Publications
    for DCK gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCK gene, integrated from 9 sources (see all 455):
    (articles sorted by number of sources associating them with DCK)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase. (PubMed id 19159229)1, 2, 9 Hazra S....Lavie A. (2009)
    2. The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. (PubMed id 16421443)2, 7, 9 Zhang Y....Ealick S.E. (2006)
    3. [Correlation of deoxycytidine kinase gene expression with fludarabine resistance in patients with chronic lymphocytic leukemia] (PubMed id 20137114)1, 7, 9 Yao L....Li J.Y. (2010)
    4. Association between single nucleotide polymorphisms in deoxycytidine kinase and treatment response among acute myeloid leukaemia patients. (PubMed id 15564883)1, 4, 9 Shi J.Y....Chen S.J. (2004)
    5. Structure of human dCK suggests strategies to improve anticancer and antiviral therapy. (PubMed id 12808445)1, 2, 9 Sabini E.... Lavie A. (2003)
    6. Characterization of human deoxycytidine kinase. Correlation with cDNA sequences. (PubMed id 2013338)1, 2, 9 Eriksson S.... Bohman C. (1991)
    7. Human deoxycytidine kinase is located in the cell nucleus. (PubMed id 9342341)1, 2, 9 Johansson M.... Karlsson A. (1997)
    8. Optimizing pemetrexed-gemcitabine combination in pati ents with advanced non-small cell lung cancer: a pharmacogenetic approach. (PubMed id 21336182)1, 7 De Pas T.M....De Braud F. (2011)
    9. Casein kinase 1delta activates human recombinant deox ycytidine kinase by Ser-74 phosphorylation, but is not involved in the in vivo regulation of its activity. (PubMed id 20637175)1, 2 Smal C....Bontemps F. (2010)
    10. Structural and kinetic characterization of human deox ycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analogues . (PubMed id 20614893)1, 2 Hazra S....Lavie A. (2010)

    External Searches for DCK gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
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    Genome Databases showing DCK gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1633 HGNC: 2704 AceView: DCK Ensembl:ENSG00000156136 euGenes: HUgn1633
    ECgene: DCK Kegg: 1633 H-InvDB: DCK

    Other Databases showing DCK gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DCK gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCK Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DCK Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DCK gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DCK gene:
    Search GeneIP for patents involving DCK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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