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Aliases for DCHS2 Gene

Aliases for DCHS2 Gene

  • Dachsous Cadherin-Related 2 2 3
  • PCDHJ 3 4 6
  • CDHJ 3 4 6
  • Cadherin-Related Family Member 7 2 3
  • Cadherin-Like Protein CDHJ 3 4
  • Protein Dachsous Homolog 2 3 4
  • Cadherin-Like Protein VR8 3 4
  • Protocadherin PCDHJ 3 4
  • Cadherin-Like 27 2 3
  • Cadherin-27 3 4
  • PCDH23 3 4
  • CDH27 3 4
  • Dachsous 2 (Drosophila) 2
  • Protocadherin 23 3
  • Protocadherin-23 3
  • CDHR7 3

External Ids for DCHS2 Gene

Previous Symbols for DCHS2 Gene

  • CDH27
  • PCDH23

Summaries for DCHS2 Gene

GeneCards Summary for DCHS2 Gene

DCHS2 (Dachsous Cadherin-Related 2) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAT4.

UniProtKB/Swiss-Prot for DCHS2 Gene

  • Calcium-dependent cell-adhesion protein.

Gene Wiki entry for DCHS2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCHS2 Gene

Genomics for DCHS2 Gene

Genomic Location for DCHS2 Gene

Start:
154,232,037 bp from pter
End:
154,491,778 bp from pter
Size:
259,742 bases
Orientation:
Minus strand

Genomic View for DCHS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCHS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCHS2 Gene

Regulatory Elements for DCHS2 Gene

Proteins for DCHS2 Gene

  • Protein details for DCHS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6V1P9-PCD23_HUMAN
    Recommended name:
    Protocadherin-23
    Protein Accession:
    Q6V1P9
    Secondary Accessions:
    • B2RU14
    • E9PC11
    • Q4W5P9
    • Q6ZS61
    • Q9NXU8

    Protein attributes for DCHS2 Gene

    Size:
    2916 amino acids
    Molecular mass:
    322234 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAY41019.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA90911.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCHS2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCHS2 Gene

Proteomics data for DCHS2 Gene at MOPED

Post-translational modifications for DCHS2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn220, Asn245, Asn406, Asn467, Asn539, Asn673, Asn820, Asn1032, Asn1140, Asn1209, Asn1443, Asn1599, Asn1615, Asn1874, Asn2024, Asn2042, Asn2100, Asn2209, Asn2474, Asn2522, and Asn2635

Other Protein References for DCHS2 Gene

No data available for DME Specific Peptides for DCHS2 Gene

Domains for DCHS2 Gene

Gene Families for DCHS2 Gene

HGNC:
  • CDHR :Cadherins / Cadherin-related

Protein Domains for DCHS2 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

PCD23_HUMAN
Domain:
  • Contains 22 cadherin domains.:
    • Q6V1P9
genes like me logo Genes that share domains with DCHS2: view

Function for DCHS2 Gene

Molecular function for DCHS2 Gene

UniProtKB/Swiss-Prot Function: Calcium-dependent cell-adhesion protein.

Gene Ontology (GO) - Molecular Function for DCHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding --
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with DCHS2: view

miRNA for DCHS2 Gene

miRTarBase miRNAs that target DCHS2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCHS2 Gene

Localization for DCHS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCHS2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCHS2 Gene COMPARTMENTS Subcellular localization image for DCHS2 gene
Compartment Confidence
plasma membrane 2
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DCHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCHS2: view

Pathways for DCHS2 Gene

SuperPathways for DCHS2 Gene

No Data Available

Interacting Proteins for DCHS2 Gene

Gene Ontology (GO) - Biological Process for DCHS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with DCHS2: view

No data available for Pathways by source for DCHS2 Gene

Compounds for DCHS2 Gene

(1) HMDB Compounds for DCHS2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with DCHS2: view

Transcripts for DCHS2 Gene

Unigene Clusters for DCHS2 Gene

Dachsous 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCHS2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - -
SP2: - - - - - - - - - -
SP3: - - -
SP4: - -

ExUns: 23 ^ 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:
SP3:
SP4:

Relevant External Links for DCHS2 Gene

GeneLoc Exon Structure for
DCHS2
ECgene alternative splicing isoforms for
DCHS2

Expression for DCHS2 Gene

mRNA expression in normal human tissues for DCHS2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DCHS2 Gene

SOURCE GeneReport for Unigene cluster for DCHS2 Gene Hs.655664

mRNA Expression by UniProt/SwissProt for DCHS2 Gene

Q6V1P9-PCD23_HUMAN
Tissue specificity: Cerebral cortex and testis.
genes like me logo Genes that share expressions with DCHS2: view

Orthologs for DCHS2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCHS2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCHS2 37
  • 98 (a)
OneToOne
LOC100614431 36
  • 98.93 (n)
  • 98.17 (a)
cow
(Bos Taurus)
Mammalia DCHS2 36
  • 79.65 (n)
  • 73.42 (a)
DCHS2 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCHS2 36
  • 84.09 (n)
  • 80.23 (a)
DCHS2 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCHS2 37
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCHS2 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dchs2 36
  • 77.56 (n)
  • 72.56 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 19 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia DCHS2 37
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dchs2 36
  • 58.64 (n)
  • 49.06 (a)
zebrafish
(Danio rerio)
Actinopterygii DCHS2 37
  • 25 (a)
OneToOne
LOC100004458 36
  • 53.03 (n)
  • 44.2 (a)
fruit fly
(Drosophila melanogaster)
Insecta ds 37
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cdh-1 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 26 (a)
OneToMany
Species with no ortholog for DCHS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCHS2 Gene

ENSEMBL:
Gene Tree for DCHS2 (if available)
TreeFam:
Gene Tree for DCHS2 (if available)

Paralogs for DCHS2 Gene

Paralogs for DCHS2 Gene

Selected SIMAP similar genes for DCHS2 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCHS2: view

Variants for DCHS2 Gene

Sequence variations from dbSNP and Humsavar for DCHS2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs4150 -- 154,484,767(-) CAGAT(A/G)TCTAT intron-variant
rs867942 -- 154,394,721(+) TGTTT(C/G)GTGCT intron-variant
rs871540 -- 154,487,878(-) CTTAT(C/T)TGATG intron-variant
rs871541 -- 154,487,452(-) TAACA(C/T)TGTCA intron-variant
rs884011 -- 154,416,060(-) AAGTT(G/T)TGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCHS2 Gene

Variant ID Type Subtype PubMed ID
nsv880812 CNV Gain 21882294
esv2658770 CNV Deletion 23128226
esv28468 CNV Loss 19812545
nsv461692 CNV Gain 19166990
nsv510924 CNV Complex 20534489
nsv507205 CNV Insertion 20534489
nsv507206 CNV Insertion 20534489
nsv830119 CNV Gain 17160897
nsv822780 CNV Gain 20364138
nsv822781 CNV Gain 20364138

Relevant External Links for DCHS2 Gene

HapMap Linkage Disequilibrium report
DCHS2
Human Gene Mutation Database (HGMD)
DCHS2

Disorders for DCHS2 Gene

Relevant External Links for DCHS2

Genetic Association Database (GAD)
DCHS2
genes like me logo Genes that share disorders with DCHS2: view

No data available for UniProtKB/Swiss-Prot for DCHS2 Gene

Publications for DCHS2 Gene

  1. Identification of new human cadherin genes using a combination of protein motif search and gene finding methods. (PMID: 15003449) Hoeng J.C. … Liu Y. (J. Mol. Biol. 2004) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Assessment of genetic determinants of the association of I^' fibrinogen in relation to cardiovascular disease. (PMID: 21757653) Lovely R.S. … Farrell D.H. (Arterioscler. Thromb. Vasc. Biol. 2011) 3 49
  4. Genome-wide association analysis of age-at-onset in Alzheimer's disease. (PMID: 22005931) Kamboh M.I. … Lopez O.L. (Mol. Psychiatry 2012) 3 49
  5. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3

Products for DCHS2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate DCHS2
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for DCHS2
    • Block miRNA regulation of DCHS2 using miScript Target Protectors

    Sources for DCHS2 Gene

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