Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DCHS1 Gene

protein-coding   GIFtS: 54
GCID: GC11M006642

Dachsous Cadherin-Related 1

(Previous names: protocadherin 16, dachsous 1 (Drosophila))
(Previous symbols: CDH25, PCDH16)
  See DCHS1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dachsous Cadherin-Related 11 2     CDHR62
PCDH161 2 3 5     cadherin-192
CDH251 2 3     cadherin-252
CDH192 3 5     Fibroblast Cadherin 12
FIB12 3 5     Fibroblast Cadherin FIB12
Cadherin-Related Family Member 61 2     protocadherin-162
Protein Dachsous Homolog 12 3     Cadherin-193
VMLDS12 5     Cadherin-253
Dachsous 1 (Drosophila)1     KIAA17733
Protocadherin 161     Fibroblast Cadherin-13

External Ids:    HGNC: 136811   Entrez Gene: 86422   Ensembl: ENSG000001663417   OMIM: 6030575   UniProtKB: Q96JQ03   

Export aliases for DCHS1 gene to outside databases

Previous GC identifers: GC11M006599 GC11M006301


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DCHS1 Gene:
This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion
molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region.
This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The
cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. (provided by RefSeq, Jul 2008)

GeneCards Summary for DCHS1 Gene:
DCHS1 (dachsous cadherin-related 1) is a protein-coding gene. Diseases associated with DCHS1 include van maldergem syndrome 1. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is DCHS2.

UniProtKB/Swiss-Prot: PCD16_HUMAN, Q96JQ0
Function: Calcium-dependent cell-adhesion protein (Potential)

Gene Wiki entry for DCHS1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_009237.19  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCHS1 gene promoter:
         AML1a   AP-1   HTF   E47   Egr-4   Max   FOXO4   PPAR-gamma2   ATF6   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCHS1 promoter sequence
   Search Chromatin IP Primers for DCHS1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCHS1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

DCHS1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCHS1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M006642:  view genomic region     (about GC identifiers)

Start:
6,642,556 bp from pter      End:
6,677,085 bp from pter
Size:
34,530 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: PCD16_HUMAN, Q96JQ0 (See protein sequence)
Recommended Name: Protocadherin-16 precursor  
Size: 3298 amino acids; 346181 Da
Sequence caution: Sequence=BAB61903.2; Type=Erroneous initiation;
Secondary accessions: O15098

Explore the universe of human proteins at neXtProt for DCHS1: NX_Q96JQ0

Explore proteomics data for DCHS1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn217, Asn256, Asn402, Asn584, Asn1249, Asn1521, Asn1718, Asn1996, Asn2361, Asn2428,
                                 Asn2569, Asn2761, Asn2792, Asn2862
  • Modification sites at PhosphoSitePlus

  • See DCHS1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003728.1  
    ENSEMBL proteins: 
     ENSP00000299441  

    DCHS1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DCHS1
    GenScript Custom Purified and Recombinant Proteins Services for DCHS1
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCHS1

     
    Search eBioscience for Proteins for DCHS1 

    DCHS1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DCHS1
    Novus Biologicals DCHS1 Antibodies
    Abcam antibodies for DCHS1
    Cloud-Clone Corp. Antibodies for DCHS1
    Search ThermoFisher Antibodies for DCHS1
    Search LSBio for Antibodies for DCHS1

    DCHS1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DCHS1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DCHS1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCHS1
    Cloud-Clone Corp. CLIAs for DCHS1
    Search eBioscience for ELISAs for DCHS1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CDHR: Cadherins / Cadherin-related

    3 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q96JQ0

    ProtoNet protein and cluster: Q96JQ0

    1 Blocks protein domain: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: PCD16_HUMAN, Q96JQ0
    Similarity: Contains 27 cadherin domains


    Find genes that share domains with DCHS1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCD16_HUMAN, Q96JQ0
    Function: Calcium-dependent cell-adhesion protein (Potential)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509calcium ion binding IEA--
         
    Find genes that share ontologies with DCHS1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DCHS1:
     G0/1 arrest  Increased G1 DNA content 

         12 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dchs1):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size/body  hearing/vestibular/ear 
     limbs/digits/tail  mortality/aging  nervous system  no phenotypic analysis  renal/urinary system 
     respiratory system  skeleton 

    Find genes that share phenotypes with DCHS1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dchs1tm1.2Irv for DCHS1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCHS1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCHS1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCHS1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCHS1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DCHS1:
    hsa-mir-335-5p (MIRT018515)

    Block miRNA regulation of human, mouse, rat DCHS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCHS1 (see all 21):
    hsa-miR-142-5p hsa-miR-485-5p hsa-miR-2110 hsa-miR-1285 hsa-miR-520a-5p hsa-miR-759 hsa-miR-3150a-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidDCHS1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DCHS1
    Predesigned siRNA for gene silencing in human, mouse, rat DCHS1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DCHS1

    Clone
    Products:
         
    OriGene clones in human, mouse for DCHS1 (see all 5)
    OriGene ORF clones in mouse, rat for DCHS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCHS1 (NM_003737)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCHS1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DCHS1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DCHS1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DCHS1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCHS1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    PCD16_HUMAN, Q96JQ0: Cell membrane; Single-pass type I membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane NAS9199196
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DCHS1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DCHS1
        S-1P Stimulated Signaling
    ILK Signaling
    GSK3 Signaling
    G12-G13 in Cellular Signaling
    WNT Signaling


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCHS1
    Interactions:

        Search GeneGlobe Interaction Network for DCHS1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCHS1 (Q96JQ03 ENSP000002994414) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LIX1LQ8IVB53, ENSP000003583144I2D: score=5 STRING: ENSP00000358314
    FAT4Q6V0I73, ENSP000003778624I2D: score=1 STRING: ENSP00000377862
    FJX1Q86VR83, ENSP000004002234I2D: score=1 STRING: ENSP00000400223
    FZD1Q9UP383, ENSP000002879344I2D: score=1 STRING: ENSP00000287934
    RYKP349253, ENSP000002960844I2D: score=1 STRING: ENSP00000296084
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007156homophilic cell adhesion IEA--
    GO:0016339calcium-dependent cell-cell adhesion NAS9199196

    Find genes that share ontologies with DCHS1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCHS1 (PCD16)

    1 HMDB Compound for DCHS1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DCHS1 gene (2 alternative transcripts): 
    NM_003737.3  NM_024542.1  

    Unigene Cluster for DCHS1:

    Dachsous 1 (Drosophila)
    Hs.199850  [show with all ESTs]
    Unigene Representative Sequence: AB053446
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000299441(uc001mem.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DCHS1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCHS1 (see all 21):
    hsa-miR-142-5p hsa-miR-485-5p hsa-miR-2110 hsa-miR-1285 hsa-miR-520a-5p hsa-miR-759 hsa-miR-3150a-3p hsa-miR-4314
    SwitchGear 3'UTR luciferase reporter plasmidDCHS1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DCHS1
    Predesigned siRNA for gene silencing in human, mouse, rat DCHS1
    Clone
    Products:
         
    OriGene clones in human, mouse for DCHS1 (see all 5)
    OriGene ORF clones in mouse, rat for DCHS1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCHS1 (NM_003737)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCHS1
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DCHS1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DCHS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCHS1
      QuantiTect SYBR Green Assays in human, mouse, rat DCHS1
      QuantiFast Probe-based Assays in human, mouse, rat DCHS1

    Additional mRNA sequence: 

    AB000895.1 AB053446.1 AK021852.1 AL831828.1 BC038382.1 

    6 DOTS entries:

    DT.442759  DT.92421739  DT.95168984  DT.100750224  DT.99952741  DT.120751357 

    Selected AceView cDNA sequences (see all 676):

    BM971099 BQ219066 BQ681772 N39806 AA861148 AA191412 BG427285 AW590772 
    CD251679 CB107021 AI242164 BM720013 CR591640 BQ003496 AW806802 BM684582 
    BM931118 BQ267771 AA035798 BF904079 BE349985 AI824389 N45929 BU069411 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DCHS1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGACCCA
    DCHS1 Expression
    About this image


    DCHS1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Placenta-derived mesenchymal stem cells (family)
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
    DCHS1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCHS1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.199850

    UniProtKB/Swiss-Prot: PCD16_HUMAN, Q96JQ0
    Tissue specificity: Fibroblast specific

        Custom PCR Arrays for DCHS1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DCHS1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCHS1
    QuantiTect SYBR Green Assays in human, mouse, rat DCHS1
    QuantiFast Probe-based Assays in human, mouse, rat DCHS1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCHS1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DCHS1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dchs11 , 5 dachsous 1 (Drosophila)1, 5 87.35(n)1
    92.71(a)1
      7 (55.98 cM)5
    2336511  NM_001162943.11  NP_001156415.11 
     1057529905 
    chicken
    (Gallus gallus)
    Aves DCHS11 dachsous 1 (Drosophila) 64.18(n)
    61.04(a)
      419073  XM_417264.4  XP_417264.4 
    lizard
    (Anolis carolinensis)
    Reptilia DCHS16
    dachsous cadherin-related 1
    54(a)
    1 ↔ 1
    GL344198.1(35744-64918)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ072271.12   -- 70.05(n)    BJ072271.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dchs1b1 dachsous 1b (Drosophila) 56.71(n)
    52.99(a)
      553300  XM_001921249.3  XP_001921284.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta ds1 dachsous 46.92(n)
    39.65(a)
      33245  NM_078722.2  NP_523446.2 
    worm
    (Caenorhabditis elegans)
    Secernentea cdh-11 cdh-1 40.93(n)
    29.61(a)
      187783  NM_065240.2  NP_497641.2 


    ENSEMBL Gene Tree for DCHS1 (if available)
    TreeFam Gene Tree for DCHS1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DCHS1 gene
    DCHS22  CELSR32  CELSR12  FAT22  PCDH152  FAT42  FAT32  CELSR22  
    FAT12  
    5 SIMAP similar genes for DCHS1 using alignment to 1 protein entry:     PCD16_HUMAN:
    DCHS2    PCDHB18    PCDHB11    PCDHB16    PCDHB17

    Find genes that share paralogs with DCHS1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DCHS1 (see all 1027)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0361104
    A colorectal cancer sample4--see VAR_0361102 R W mis40--------
    rs617353291,2
    F--6642745(+) GGGCAG/CGGATC 1 -- ut312Minor allele frequency- C:0.38NS NA 192
    rs1442676221,2
    C--6642758(+) TCACT-/GAGGAGAA 1 -- cds10--------
    rs773077731,2
    C--6642835(+) CAGGGC/TTTCTG 1 -- ut310--------
    rs2014367861,2
    C--6643073(+) GAGGCC/TGAGGG 2 S syn10--------
    rs617353311,2
    C,F--6643110(+) CAACGG/AGTGAG 2 /P /L mis12Minor allele frequency- A:0.00NS NA 4494
    rs2009635311,2
    --6643117(+) TGAGCA/GAGCAG 2 R C mis10--------
    rs1397630431,2
    C--6643120(+) GCGAGC/TAGCCA 2 T A mis11Minor allele frequency- T:0.00NA 4430
    rs1882981001,2
    C--6643162(+) CATGGA/CAGCTG 2 A S mis10--------
    rs1807723211,2
    --6643163(+) ATGGCA/GGCTGA 2 A syn10--------

    HapMap Linkage Disequilibrium report for DCHS1 (6642556 - 6677085 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCHS1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24387CNV Gain19812545
    nsv825755CNV Gain20364138

    Human Gene Mutation Database (HGMD): DCHS1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCHS1
    DNA2.0 Custom Variant and Variant Library Synthesis for DCHS1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 603057   
    OMIM disorders: 601390  
    1 disease for DCHS1:    
    About MalaCards
    van maldergem syndrome 1


    Find genes that share disorders with DCHS1           About GenesLikeMe

    Genetic Association Database (GAD): DCHS1
    Human Genome Epidemiology (HuGE) Navigator: DCHS1 (1 document)

    Export disorders for DCHS1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DCHS1 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DCHS1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Multiple cadherins are expressed in human fibroblasts. (PubMed id 9199196)1, 2, 3 Matsuyoshi N. and Imamura S. (Biochem. Biophys. Res. Commun. 1997)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs. (PubMed id 11597768)1, 2 Nakajima D.... Ohara O. (Brain Res. Mol. Brain Res. 2001)
    4. Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. (PubMed id 24056717)1 Cappello S....Robertson S.P. (Nat. Genet. 2013)
    5. Mindbomb 1, an E3 ubiquitin ligase, forms a complex with RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (J. Cell Biol. 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PubMed id 17903297)4 Seshadri S....Wolf P.A. (BMC Med. Genet. 2007)
    8. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. Cadherin-19 expression is restricted to myelin-forming cells in the chicken embryo. (PubMed id 19850111)9 Lin J....Redies C. (Neuroscience 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8642 HGNC: 13681 AceView: CLN2andDCHS1 Ensembl:ENSG00000166341 euGenes: HUgn8642
    ECgene: DCHS1 H-InvDB: DCHS1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA1773

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DCHS1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DCHS1 gene:
    Search GeneIP for patents involving DCHS1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DCHS1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DCHS1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DCHS1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DCHS1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DCHS1   OriGene Custom Protein Services for DCHS1  

     
     
     Block miRNA regulation of human, mouse, rat DCHS1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DCHS1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCHS1 Predesigned siRNA for gene silencing in human, mouse, rat DCHS1
     QuantiFast Probe-based Assays in human, mouse, rat DCHS1 QuantiTect SYBR Green Assays in human, mouse, rat DCHS1
     Custom PCR Arrays for DCHS1 Search Chromatin IP Primers for DCHS1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCHS1  Search GeneGlobe Interaction Network for DCHS1
     Regulatory tfbs in DCHS1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DCHS1 GenScript cDNA clones with any tag delivered in your preferred vector for DCHS1
     GenScript Custom Assay Services for DCHS1 GenScript Custom overexpressing Cell Line Services for DCHS1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DCHS1 (PCD16)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DCHS1 antibodies
     Antibodies for DCHS1
     See all of Abcam's Antibodies, Kits and Proteins for DCHS1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DCHS1
     Antibodies for DCHS1
     ELISAs for DCHS1
     CLIAs for DCHS1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DCHS1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCHS1
     SwitchGear 3'UTR luciferase reporter plasmids for DCHS1
     SwitchGear Promoter luciferase reporter plasmids for DCHS1
     Search ThermoFisher Antibodies for DCHS1
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DCHS1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCHS1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCHS1
     Search LSBio for Antibodies for DCHS1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DCHS1
      Search eBioscience for proteins for DCHS1
      Search eBioscience for elisas for DCHS1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DCHS1 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4