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Aliases for DCHS1 Gene

Aliases for DCHS1 Gene

  • Dachsous Cadherin-Related 1 2 3
  • PCDH16 3 4 6
  • CDH19 3 4 6
  • FIB1 3 4 6
  • Cadherin-Related Family Member 6 2 3
  • Protein Dachsous Homolog 1 3 4
  • Cadherin-19 3 4
  • Cadherin-25 3 4
  • VMLDS1 3 6
  • CDH25 3 4
  • Fibroblast Cadherin FIB1 3
  • Dachsous 1 (Drosophila) 2
  • Fibroblast Cadherin 1 3
  • Fibroblast Cadherin-1 4
  • Protocadherin 16 2
  • Protocadherin-16 3
  • KIAA1773 4
  • CDHR6 3

External Ids for DCHS1 Gene

Previous HGNC Symbols for DCHS1 Gene

  • CDH25
  • PCDH16

Previous GeneCards Identifiers for DCHS1 Gene

  • GC11M006599
  • GC11M006301

Summaries for DCHS1 Gene

Entrez Gene Summary for DCHS1 Gene

  • This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCHS1 Gene

DCHS1 (Dachsous Cadherin-Related 1) is a Protein Coding gene. Diseases associated with DCHS1 include van maldergem syndrome 1 and van maldergem syndrome. Among its related pathways are ERK Signaling and ERK Signaling. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is FAT4.

UniProtKB/Swiss-Prot for DCHS1 Gene

  • Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation

Gene Wiki entry for DCHS1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCHS1 Gene

Genomics for DCHS1 Gene

Regulatory Elements for DCHS1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCHS1 Gene

6,621,323 bp from pter
6,664,089 bp from pter
42,767 bases
Minus strand

Genomic View for DCHS1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCHS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCHS1 Gene

Proteins for DCHS1 Gene

  • Protein details for DCHS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • O15098

    Protein attributes for DCHS1 Gene

    3298 amino acids
    Molecular mass:
    346181 Da
    Quaternary structure:
    • Heterophilic interaction with FAT4; this interaction affects their respective protein levels.
    • Sequence=BAB61903.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DCHS1 Gene

Proteomics data for DCHS1 Gene at MOPED

Post-translational modifications for DCHS1 Gene

  • Glycosylation at Asn217, Asn256, Asn402, Asn584, Asn1249, Asn1521, Asn1718, Asn1996, Asn2361, Asn2428, Asn2569, Asn2761, Asn2792, and Asn2862
  • Modification sites at PhosphoSitePlus

Other Protein References for DCHS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCHS1 Gene

Domains for DCHS1 Gene

Gene Families for DCHS1 Gene

  • CDHR :Cadherins / Cadherin-related

Protein Domains for DCHS1 Gene


Suggested Antigen Peptide Sequences for DCHS1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96JQ0
  • Contains 27 cadherin domains.
genes like me logo Genes that share domains with DCHS1: view

Function for DCHS1 Gene

Molecular function for DCHS1 Gene

UniProtKB/Swiss-Prot Function:
Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation

Gene Ontology (GO) - Molecular Function for DCHS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with DCHS1: view
genes like me logo Genes that share phenotypes with DCHS1: view

Animal Models for DCHS1 Gene

MGI Knock Outs for DCHS1:

Animal Model Products

miRNA for DCHS1 Gene

miRTarBase miRNAs that target DCHS1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCHS1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DCHS1 Gene

Localization for DCHS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCHS1 Gene

Cell membrane; Single-pass type I membrane protein. Note=In the embryonic cortex, FAT4 and DCHS1 accumulated at the cell-cell boundaries located apical to the adherens junction. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for DCHS1 Gene COMPARTMENTS Subcellular localization image for DCHS1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DCHS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane NAS 9199196
GO:0016021 integral component of membrane IEA --
GO:0045177 apical part of cell IEA --
genes like me logo Genes that share ontologies with DCHS1: view

Pathways for DCHS1 Gene

genes like me logo Genes that share pathways with DCHS1: view

Gene Ontology (GO) - Biological Process for DCHS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001658 branching involved in ureteric bud morphogenesis IEA --
GO:0001822 kidney development --
GO:0003007 heart morphogenesis IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ISS --
genes like me logo Genes that share ontologies with DCHS1: view

Compounds for DCHS1 Gene

(1) HMDB Compounds for DCHS1 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with DCHS1: view

Transcripts for DCHS1 Gene

mRNA/cDNA for DCHS1 Gene

(676) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCHS1 Gene

Dachsous 1 (Drosophila):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCHS1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCHS1 Gene

No ASD Table

Relevant External Links for DCHS1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCHS1 Gene

mRNA expression in normal human tissues for DCHS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DCHS1 Gene

This gene is overexpressed in Fetal Brain (31.3) and Liver, secretome (7.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DCHS1 Gene

SOURCE GeneReport for Unigene cluster for DCHS1 Gene Hs.199850

mRNA Expression by UniProt/SwissProt for DCHS1 Gene

Tissue specificity: Expressed in fibroblasts but not in melanocytes or keratinocytes.
genes like me logo Genes that share expressions with DCHS1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Expression partners for DCHS1 Gene

Orthologs for DCHS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCHS1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCHS1 35
  • 89.32 (n)
  • 93.78 (a)
DCHS1 36
  • 94 (a)
(Canis familiaris)
Mammalia DCHS1 35
  • 90.41 (n)
  • 94.42 (a)
DCHS1 36
  • 90 (a)
(Mus musculus)
Mammalia Dchs1 35
  • 87.35 (n)
  • 92.71 (a)
Dchs1 16
Dchs1 36
  • 93 (a)
(Pan troglodytes)
Mammalia DCHS1 35
  • 98.26 (n)
  • 97.96 (a)
DCHS1 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dchs1 35
  • 87.15 (n)
  • 92.1 (a)
(Monodelphis domestica)
Mammalia DCHS1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 23 (a)
(Gallus gallus)
Aves DCHS1 35
  • 64.18 (n)
  • 61.04 (a)
DCHS1 36
  • 60 (a)
(Anolis carolinensis)
Reptilia DCHS1 36
  • 54 (a)
(Danio rerio)
Actinopterygii dchs1b 35
  • 56.71 (n)
  • 52.99 (a)
dchs1a 36
  • 51 (a)
dchs1b 36
  • 51 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007905 35
  • 47.73 (n)
  • 37.18 (a)
fruit fly
(Drosophila melanogaster)
Insecta ds 35
  • 46.92 (n)
  • 39.65 (a)
ds 36
  • 33 (a)
(Caenorhabditis elegans)
Secernentea cdh-1 35
  • 40.93 (n)
  • 29.61 (a)
cdh-1 36
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 33 (a)
Species with no ortholog for DCHS1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DCHS1 Gene

Gene Tree for DCHS1 (if available)
Gene Tree for DCHS1 (if available)

Paralogs for DCHS1 Gene

Paralogs for DCHS1 Gene

Selected SIMAP similar genes for DCHS1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCHS1: view

Variants for DCHS1 Gene

Sequence variations from dbSNP and Humsavar for DCHS1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs937850 -- 6,647,944(-) CCTTC(A/C)CCTCC intron-variant
rs937851 -- 6,646,122(-) GTGTG(C/T)GTATG intron-variant
rs937852 -- 6,645,859(-) ATGTG(A/C)ATCTG intron-variant
rs937855 -- 6,665,299(-) GGATA(C/T)ACTTT upstream-variant-2KB
rs937856 -- 6,662,311(-) GAGCC(A/C)AATCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCHS1 Gene

Variant ID Type Subtype PubMed ID
nsv825755 CNV Gain 20364138
esv24387 CNV Gain 19812545

Relevant External Links for DCHS1 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCHS1 Gene

Disorders for DCHS1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DCHS1 Gene in MalaCards »

(2) Diseases for DCHS1 Gene including...

(1) OMIM Diseases for DCHS1 Gene (603057)


  • Van Maldergem syndrome 1 (VMLDS1) [MIM:601390]: An autosomal recessive disorder characterized by intellectual disability, typical craniofacial features, auditory malformations resulting in hearing loss, and skeletal and limb malformations. Some patients have renal hypoplasia. Brain MRI typically shows periventricular nodular heterotopia. {ECO:0000269 PubMed:24056717}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DCHS1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DCHS1: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DCHS1 Gene

Publications for DCHS1 Gene

  1. Multiple cadherins are expressed in human fibroblasts. (PMID: 9199196) Matsuyoshi N. … Imamura S. (Biochem. Biophys. Res. Commun. 1997) 2 3 4
  2. Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs. (PMID: 11597768) Nakajima D. … Ohara O. (Brain Res. Mol. Brain Res. 2001) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development. (PMID: 24056717) Cappello S. … Robertson S.P. (Nat. Genet. 2013) 3 4
  5. Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study. (PMID: 17903297) Seshadri S. … Wolf P.A. (BMC Med. Genet. 2007) 48

Products for DCHS1 Gene

Sources for DCHS1 Gene

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