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Aliases for DCDC5 Gene

Aliases for DCDC5 Gene

  • Doublecortin Domain Containing 5 2 3
  • Doublecortin Domain Containing 1 5
  • KIAA1493 4
  • DCDC1 5

External Ids for DCDC5 Gene

Previous GeneCards Identifiers for DCDC5 Gene

  • GC11M030809

Summaries for DCDC5 Gene

Entrez Gene Summary for DCDC5 Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found, but the full-length nature of some variants is not determined. [provided by RefSeq, Feb 2011]

GeneCards Summary for DCDC5 Gene

DCDC5 (Doublecortin Domain Containing 5) is a Protein Coding gene. Diseases associated with DCDC5 include Iris Disease.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC5 Gene

Genomics for DCDC5 Gene

Regulatory Elements for DCDC5 Gene


Promoters for DCDC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000560517 -291 2199 HDGF PKNOX1 ATF1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF48 ZNF2

Genomic Location for DCDC5 Gene

Chromosome:
11
Start:
30,830,369 bp from pter
End:
31,369,810 bp from pter
Size:
539,442 bases
Orientation:
Minus strand

Genomic View for DCDC5 Gene

Genes around DCDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC5 Gene

Proteins for DCDC5 Gene

  • Protein details for DCDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRR9-DCDC5_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 5
    Protein Accession:
    Q6ZRR9
    Secondary Accessions:
    • B1AL47

    Protein attributes for DCDC5 Gene

    Size:
    648 amino acids
    Molecular mass:
    72753 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=CAO03425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DCDC5 Gene

Post-translational modifications for DCDC5 Gene

No Post-translational modifications

Other Protein References for DCDC5 Gene

No data available for DME Specific Peptides for DCDC5 Gene

Domains & Families for DCDC5 Gene

Gene Families for DCDC5 Gene

Protein Domains for DCDC5 Gene

Suggested Antigen Peptide Sequences for DCDC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZRR9

UniProtKB/Swiss-Prot:

DCDC5_HUMAN :
  • Contains 2 doublecortin domains.
Domain:
  • Contains 2 doublecortin domains.
genes like me logo Genes that share domains with DCDC5: view

Function for DCDC5 Gene

genes like me logo Genes that share phenotypes with DCDC5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC5 Gene

Localization for DCDC5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCDC5 Gene COMPARTMENTS Subcellular localization image for DCDC5 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DCDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with DCDC5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCDC5 Gene

Pathways & Interactions for DCDC5 Gene

SuperPathways for DCDC5 Gene

No Data Available

Interacting Proteins for DCDC5 Gene

Gene Ontology (GO) - Biological Process for DCDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC5: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC5 Gene

Transcripts for DCDC5 Gene

mRNA/cDNA for DCDC5 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCDC5 Gene

Doublecortin domain containing 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2:
SP3:

Relevant External Links for DCDC5 Gene

GeneLoc Exon Structure for
DCDC5
ECgene alternative splicing isoforms for
DCDC5

Expression for DCDC5 Gene

mRNA expression in normal human tissues for DCDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCDC5 Gene

This gene is overexpressed in Amniocyte (52.4) and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCDC5 Gene



Protein tissue co-expression partners for DCDC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCDC5 Gene:

DCDC5

SOURCE GeneReport for Unigene cluster for DCDC5 Gene:

Hs.530438
genes like me logo Genes that share expression patterns with DCDC5: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCDC5 Gene

Orthologs for DCDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCDC5 34
  • 99.38 (n)
DCDC1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475957 34
  • 87.26 (n)
DCDC1 35
  • 69 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCDC5 34
  • 85.49 (n)
DCDC1 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcdc5 34 16
  • 76.64 (n)
rat
(Rattus norvegicus)
Mammalia Dcdc5 34
  • 74.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC1 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC1 35
  • 58 (a)
OneToOne
Species where no ortholog for DCDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC5 Gene

ENSEMBL:
Gene Tree for DCDC5 (if available)
TreeFam:
Gene Tree for DCDC5 (if available)

Paralogs for DCDC5 Gene

(2) SIMAP similar genes for DCDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCDC5: view

No data available for Paralogs for DCDC5 Gene

Variants for DCDC5 Gene

Sequence variations from dbSNP and Humsavar for DCDC5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10566619 -- 30,945,747(+) ATCTA(-/TCTG)TCTGT intron-variant
rs10573154 -- 30,969,093(+) AAAAC(-/AA)AGAGT intron-variant
rs10637054 -- 30,923,416(+) CTCCT(-/TT)TTTTT intron-variant
rs10676261 -- 30,923,417(+) TTTTT(-/TT)GCTTA intron-variant
rs10688130 -- 30,879,979(+) CACAC(-/AT)GTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC5 Gene

Variant ID Type Subtype PubMed ID
dgv1088n100 CNV loss 25217958
esv1245858 CNV insertion 17803354
esv2540017 CNV loss 19546169
esv2759814 CNV loss 17122850
esv3411357 CNV insertion 20981092
esv3625821 CNV gain 21293372
nsv1035755 CNV gain 25217958
nsv1122602 CNV deletion 24896259
nsv1147322 CNV duplication 26484159
nsv473260 CNV novel sequence insertion 20440878
nsv480627 CNV novel sequence insertion 20440878
nsv507588 OTHER sequence alteration 20534489
nsv513309 CNV insertion 21212237
nsv516888 CNV loss 19592680
nsv529004 CNV loss 19592680
nsv553947 CNV gain 21841781
nsv553948 CNV loss 21841781

Relevant External Links for DCDC5 Gene

Human Gene Mutation Database (HGMD)
DCDC5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCDC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DCDC5 Gene

Disorders for DCDC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCDC5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
iris disease
  • iris diseases
- elite association - COSMIC cancer census association via MalaCards
Search DCDC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCDC5

Genetic Association Database (GAD)
DCDC5
Human Genome Epidemiology (HuGE) Navigator
DCDC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCDC5
genes like me logo Genes that share disorders with DCDC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCDC5 Gene

Publications for DCDC5 Gene

  1. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 46 64
  2. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 2 3 64
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K. … Rivadeneira F. (Nat. Genet. 2012) 3 64

Products for DCDC5 Gene

Sources for DCDC5 Gene

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