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Aliases for DCDC5 Gene

Aliases for DCDC5 Gene

  • Doublecortin Domain Containing 5 2 3
  • Doublecortin Domain Containing 1 5
  • KIAA1493 4
  • DCDC1 5

External Ids for DCDC5 Gene

Previous GeneCards Identifiers for DCDC5 Gene

  • GC11M030809

Summaries for DCDC5 Gene

Entrez Gene Summary for DCDC5 Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found, but the full-length nature of some variants is not determined. [provided by RefSeq, Feb 2011]

GeneCards Summary for DCDC5 Gene

DCDC5 (Doublecortin Domain Containing 5) is a Protein Coding gene. Diseases associated with DCDC5 include iris disease.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC5 Gene

Genomics for DCDC5 Gene

Regulatory Elements for DCDC5 Gene

Promoters for DCDC5 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCDC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCDC5 Gene

Chromosome:
11
Start:
30,830,369 bp from pter
End:
31,369,810 bp from pter
Size:
539,442 bases
Orientation:
Minus strand

Genomic View for DCDC5 Gene

Genes around DCDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC5 Gene

Proteins for DCDC5 Gene

  • Protein details for DCDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRR9-DCDC5_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 5
    Protein Accession:
    Q6ZRR9
    Secondary Accessions:
    • B1AL47

    Protein attributes for DCDC5 Gene

    Size:
    648 amino acids
    Molecular mass:
    72753 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=CAO03425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DCDC5 Gene

Proteomics data for DCDC5 Gene at MOPED

Post-translational modifications for DCDC5 Gene

No Post-translational modifications

Other Protein References for DCDC5 Gene

No data available for DME Specific Peptides for DCDC5 Gene

Domains & Families for DCDC5 Gene

Protein Domains for DCDC5 Gene

Suggested Antigen Peptide Sequences for DCDC5 Gene

Graphical View of Domain Structure for InterPro Entry

Q6ZRR9

UniProtKB/Swiss-Prot:

DCDC5_HUMAN :
  • Contains 2 doublecortin domains.
Domain:
  • Contains 2 doublecortin domains.
genes like me logo Genes that share domains with DCDC5: view

No data available for Gene Families for DCDC5 Gene

Function for DCDC5 Gene

genes like me logo Genes that share phenotypes with DCDC5: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC5 Gene

Localization for DCDC5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCDC5 Gene COMPARTMENTS Subcellular localization image for DCDC5 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCDC5 Gene

Pathways & Interactions for DCDC5 Gene

SuperPathways for DCDC5 Gene

No Data Available

Interacting Proteins for DCDC5 Gene

Gene Ontology (GO) - Biological Process for DCDC5 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCDC5 Gene

Drugs & Compounds for DCDC5 Gene

No Compound Related Data Available

Transcripts for DCDC5 Gene

mRNA/cDNA for DCDC5 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCDC5 Gene

Doublecortin domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2:
SP3:

Relevant External Links for DCDC5 Gene

GeneLoc Exon Structure for
DCDC5
ECgene alternative splicing isoforms for
DCDC5

Expression for DCDC5 Gene

mRNA expression in normal human tissues for DCDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCDC5 Gene

This gene is overexpressed in Amniocyte (52.4) and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCDC5 Gene



SOURCE GeneReport for Unigene cluster for DCDC5 Gene Hs.530438

genes like me logo Genes that share expression patterns with DCDC5: view

Protein tissue co-expression partners for DCDC5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCDC5 Gene

Orthologs for DCDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCDC5 35
  • 85.49 (n)
  • 80.05 (a)
DCDC1 36
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC475957 35
  • 87.26 (n)
  • 82.99 (a)
DCDC1 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcdc5 35
  • 76.64 (n)
  • 67.14 (a)
Dcdc5 16
chimpanzee
(Pan troglodytes)
Mammalia DCDC5 35
  • 99.38 (n)
  • 99.42 (a)
DCDC1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcdc5 35
  • 74.3 (n)
  • 65.67 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC1 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC1 36
  • 58 (a)
OneToOne
Species with no ortholog for DCDC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC5 Gene

ENSEMBL:
Gene Tree for DCDC5 (if available)
TreeFam:
Gene Tree for DCDC5 (if available)

Paralogs for DCDC5 Gene

(2) SIMAP similar genes for DCDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCDC5: view

No data available for Paralogs for DCDC5 Gene

Variants for DCDC5 Gene

Sequence variations from dbSNP and Humsavar for DCDC5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs192648 -- 30,943,636(+) AGAGT(A/G)AGAAA intron-variant
rs151457 -- 30,969,557(+) gtttg(A/C)ggcag intron-variant
rs156398 -- 30,936,671(+) agtag(A/G)aacac intron-variant
rs156399 -- 30,934,400(+) gttat(A/G)gaagt intron-variant
rs158505 -- 30,959,701(-) TCTGG(A/G)TTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC5 Gene

Variant ID Type Subtype PubMed ID
nsv897173 CNV Loss 21882294
nsv897174 CNV Loss 21882294
nsv507588 CNV Insertion 20534489
esv2540017 CNV Loss 19546169
nsv513309 CNV Insertion 21212237
esv1245858 CNV Insertion 17803354
nsv897175 CNV Gain 21882294
essv17950 CNV CNV 17122850
nsv516888 CNV Loss 19592680
nsv897176 CNV Gain 21882294
nsv529004 CNV Loss 19592680

Relevant External Links for DCDC5 Gene

HapMap Linkage Disequilibrium report
DCDC5
Human Gene Mutation Database (HGMD)
DCDC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for DCDC5 Gene

Disorders for DCDC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCDC5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
iris disease
  • iris diseases
- elite association - COSMIC cancer census association via MalaCards
Search DCDC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCDC5

Genetic Association Database (GAD)
DCDC5
Human Genome Epidemiology (HuGE) Navigator
DCDC5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCDC5
genes like me logo Genes that share disorders with DCDC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCDC5 Gene

Publications for DCDC5 Gene

  1. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 48 67
  2. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 2 3
  3. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PMID: 22504420) Estrada K. … Rivadeneira F. (Nat. Genet. 2012) 3
  4. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PMID: 22797727) Okada Y. … Tanaka T. (Nat. Genet. 2012) 3
  5. Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein. (PMID: 22159412) Kaplan A. … Reiner O. (J. Cell. Sci. 2011) 3

Products for DCDC5 Gene

Sources for DCDC5 Gene

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