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DCDC5 Gene

protein-coding   GIFtS: 41
GCID: GC11M030885

Doublecortin Domain Containing 5

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Doublecortin Domain Containing 51 2
KIAA14933 5
Doublecortin Domain-Containing Protein 52

External Ids:    HGNC: 247991   Entrez Gene: 1005066272   OMIM: 6123215   UniProtKB: Q6ZRR93   

Export aliases for DCDC5 gene to outside databases

Previous GC identifer: GC11M030809


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCDC5 Gene:
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin
domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization.
Alternatively spliced transcript variants encoding distinct isoforms have been found, but the full-length nature
of some variants is not determined. (provided by RefSeq, Feb 2011)

GeneCards Summary for DCDC5 Gene:
DCDC5 (doublecortin domain containing 5) is a protein-coding gene. Diseases associated with DCDC5 include neuronitis.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCDC5 gene promoter:
         LHX3b/Lhx3b   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   Cdc5   POU3F2   Arnt   E47   POU2F1   POU2F1a   LHX3a/Lhx3a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DCDC5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCDC5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.1   HGNC cytogenetic band: 11p14.1

DCDC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCDC5 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M030885:  view genomic region     (about GC identifiers)

Start:
30,885,150 bp from pter      End:
31,014,233 bp from pter
Size:
129,084 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DCDC5_HUMAN, Q6ZRR9 (See protein sequence)
Recommended Name: Doublecortin domain-containing protein 5  
Size: 648 amino acids; 72753 Da
Sequence caution: Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Sequence=CAO03425.1; Type=Erroneous gene
model prediction;
Secondary accessions: B1AL47

Explore the universe of human proteins at neXtProt for DCDC5: NX_Q6ZRR9

Explore proteomics data for DCDC5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DCDC5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065920.2  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR000772 Ricin_B_lectin
     IPR003533 Doublecortin_dom

    Graphical View of Domain Structure for InterPro Entry Q6ZRR9

    ProtoNet protein and cluster: Q6ZRR9

    1 Blocks protein domain: IPB000772 Ricin B lectin domain

    UniProtKB/Swiss-Prot: DCDC5_HUMAN, Q6ZRR9
    Similarity: Contains 2 doublecortin domains


    DCDC5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for DCDC5:
     Decreased homologous recombina 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    golgi apparatus1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCDC5
    Interactions:

        Search GeneGlobe Interaction Network for DCDC5

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035556intracellular signal transduction IEA--

    DCDC5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCDC5



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCDC5 gene (2 alternative transcripts): 
    NM_198462.2  NM_020869.3  

    Unigene Cluster for DCDC5:

    Doublecortin domain containing 5
    Hs.530438  [show with all ESTs]
    Unigene Representative Sequence: NM_020869
    miRNA
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    4 DOTS entries:

    DT.430080  DT.101978078  DT.92013273  DT.307316 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCDC5 expression in normal human tissues (normalized intensities)      DCDC5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DCDC5 Expression
    About this image


    DCDC5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Telencephalon
     
     Brain (Nervous System)
             Medulla Oblongata
    DCDC5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCDC5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.530438
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCDC5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for DCDC5 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcdc51 , 5 doublecortin domain containing 51, 5 76.64(n)1
    67.14(a)1
      2 (55.58 cM)5
    3294821  XM_006500500.11  XP_006500563.11 
     1060033365 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCDC5 gene
    2 SIMAP similar genes for DCDC5 using alignment to 1 protein entry:     DCDC5_HUMAN:
    DCDC1    KIAA1493

    DCDC5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCDC5 (see all 2315)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447685161,2
    C--30884718(+) CTGAAC/TGCTTG 1 -- int10--------
    rs1478972491,2
    --30884798(+) AACCCA/CAGGTG 1 -- int10--------
    rs1415784241,2
    --30884943(+) GGAAAA/GCAGTA 1 -- int10--------
    rs1909355381,2
    --30885238(+) GACGCA/GTATTT 1 -- ut310--------
    rs1428111231,2
    C--30885254(+) TCATCC/TATTTG 1 -- ut310--------
    rs1830800381,2
    --30885301(+) TTATGA/GAAATG 1 -- ut310--------
    rs1879632231,2
    --30885535(+) TGGGTA/GTGGTG 1 -- ut310--------
    rs1906496411,2
    --30885766(+) GAACTC/GCTTCA 1 -- ut310--------
    rs1176641671,2
    F--30885783(+) CCTGTC/TGAAGT 1 -- ut311Minor allele frequency- T:0.04EA 120
    rs1510283491,2
    --30885791(+) AGTCTC/GAAATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DCDC5 (30885150 - 31014233 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DCDC5 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1245858CNV Insertion17803354
    nsv507588CNV Insertion20534489
    nsv513309CNV Insertion21212237
    nsv897174CNV Loss21882294
    esv2540017CNV Loss19546169
    nsv529004CNV Loss19592680
    nsv516888CNV Loss19592680
    nsv897173CNV Loss21882294
    nsv897176CNV Gain21882294
    nsv897175CNV Gain21882294

    Human Gene Mutation Database (HGMD): DCDC5
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DCDC5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612321    OMIM disorders: --

    1 disease for DCDC5:    About MalaCards
    neuronitis


    DCDC5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DCDC5
    Human Genome Epidemiology (HuGE) Navigator: DCDC5 (3 documents)

    Export disorders for DCDC5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCDC5 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with DCDC5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1, 4 Rivadeneira F....Uitterlinden A.G. (Nat. Genet. 2009)
    2. The evolving doublecortin (DCX) superfamily. (PubMed id 16869982)1, 3 Reiner O.... Bergmann S. (BMC Genomics 2006)
    3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. (PubMed id 22504420)1 Estrada K....Rivadeneira F. (Nat. Genet. 2012)
    6. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PubMed id 22797727)1 Okada Y....Tanaka T. (Nat. Genet. 2012)
    7. Linking cytoplasmic dynein and transport of Rab8 vesicles to the midbody during cytokinesis by the doublecortin domain-containing 5 protein. (PubMed id 22159412)1 Kaplan A. and Reiner O. (J. Cell. Sci. 2011)
    8. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    9. The doublecortin gene family and disorders of neuronal structure. (PubMed id 20236041)1 Dijkmans T.F.... Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010)
    10. Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels. (PubMed id 20700443)1 Meyer T.E.... . (PLoS Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 100506627 HGNC: 24799 euGenes: HUgn100506627 ECgene: DCDC5 H-InvDB: DCDC5

    (According to HUGE)
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    HUGE: KIAA1493

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCDC5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCDC5 gene:
    Search GeneIP for patents involving DCDC5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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