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DCDC5 Gene

protein-coding   GIFtS: 43

GC11M030809
doublecortin domain containing 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
FLJ46154 1, 2
KIAA1493 2, 3, 5
Descriptions
doublecortin domain containing 5 2
External Ids
HGNC: 247991
Entrez Gene: 1962962
UniProtKB: Q6ZRR93
Ensembl: ENSG000001709597
Search outside databases for aliases for DCDC5 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p14.1-p13   Ensembl cytogenetic band:  11p14.1   HGNC cytogenetic band: 11p14.1

DCDC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M030809:     (about GC identifiers)

Start:
30,841,730 bp from pter
End:
31,105,751 bp from pter
Size:
264,022 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_009237.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DCDC5_HUMAN, Q6ZRR9 (See protein sequence)
Recommended Name: Doublecortin domain-containing protein 5  
Size: 648 amino acids; 72753 Da
Sequence caution: Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Sequence=CAO03425.1;
Type=Erroneous gene model prediction;
Secondary accessions: B1AL47

REFSEQ proteins: NP_940864.2  

ENSEMBL proteins: 
ENSP00000385936 ENSP00000306898 ENSP00000341700 


Human Recombinant Proteins 
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                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for DCDC5: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for DCDC5

Assays for DCDC5: 
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Browse Kits and Assays available from Millipore
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Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR003533 DCX


   GeneDecks  DCDC5 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry Q6ZRR9

ProtoNet protein and cluster: Q6ZRR9

1 Blocks protein family: IPB000772 Ricin B lectin domain

UniProtKB/Swiss-Prot: DCDC5_HUMAN, Q6ZRR9
Similarity: Contains 2 doublecortin domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_198462

              Applied Biosystems Silencer® siRNAs for DCDC5

              Sigma-Aldrich siRNA for DCDC5  
                     Sigma-Aldrich shRNA for DCDC5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_198462
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_198462
                                 untagged cDNA clone in CMV expression vector: NM_198462 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_198462

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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  --

1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007242 intracellular signaling cascade IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DCDC5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene)
About This Section

Inhib.
RNA:
Browse Invitrogen for RNAi
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_198462

              Sigma-Aldrich siRNA for DCDC5  
                     Sigma-Aldrich shRNA for DCDC5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

REFSEQ mRNAs for DCDC5 gene: 

NM_198462.2   


              OriGene GFP tagged cDNA clone in CMV expression vector: NM_198462
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_198462
                                 untagged cDNA clone in CMV expression vector: NM_198462 

Additional cDNA sequence: AK128035.1 

4 DOTS entries:

DT.75168958  DT.101978078  DT.430080  DT.92013273 

24/29 AceView cDNA sequences (see all 29 ):

BX117620 NM_198462 AA833549 BX097338 AI056882 BX116244 AK128035 AA005095 
AI040110 AW340116 AK126066 AB040926 BX647348 AA846321 AA004887 AI243215 
AY247970 BF957112 AA954541 AI684432 NM_181807 AI150472 AA680369 T55506 

highest scoring ESTs for DCDC5:

AI056882 AK128035 BX647348 W04903 CN429222 DB061478 AA004887 AA005095 AA680369 AA833549 

Unigene Cluster for DCDC5:

Doublecortin domain containing 5
Hs.530438  [show with all ESTs]
Unigene Representative Sequence: AK128035


GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DCDC5

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1:                                                              -           -                                             
SP2:                                                                                                                        
SP3:                                                                                                                        

About this scheme

ECgene alternative splicing isoforms for DCDC5

3 Ensembl transcripts including schematic representations:
ENST00000406071  ENST00000303697  ENST00000339794  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DCDC5 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for DCDC5

1 / 2 / 3

4 probe-sets matching DCDC5 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
47355_at2, 3 U95-B 1 1.00 1.00 0.79 1.16 AI056882 0.80 0.88 0.84 1
79499_at2, 3 U95-D 1 1.00 1.00 0.98 0.88 W04903 0.80 0.88 0.84 1

232603_at2, 3 U133-B 1 1.00 1.00 -- -- T55506 0.60 0.83 0.73 1

232603_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  DCDC5 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: GCAACTGGTC

SOURCE GeneReport for Unigene cluster: Hs.530438
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for DCDC5 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
DCDC51   -- doublecortin domain containing 5 86.82(n)
82.32(a)
475957  XM_533167.2  XP_533167.2 
chimpanzee
(Pan troglodytes)
DCDC51   -- doublecortin domain containing 5 99.36(n)
99.4(a)
451101  XM_508349.2  XP_508349.2 
cow
(Bos taurus)
DCDC51   -- doublecortin domain containing 5 84.28(n)
78.51(a)
529596  XM_608048.3  XP_608048.3 
rat
(Rattus norvegicus)
Dcdc51   -- doublecortin domain containing 5 73.7(n)
64.13(a)
295980  XM_230359.4  XP_230359.4 
mouse
(Mus musculus)
Dcdc55 2 doublecortin domain containing 5   -- BX649317 
About this table        Species with no ortholog for DCDC5

ENSEMBL Gene Tree for DCDC5
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
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  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/1000 NCBI SNPs in DCDC5 are shown (see all 1000 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 460)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs2890801,2
A,C,F,H31042691(+) AATGGG/TTGTCT 1 T/N mis18Minor allele frequency- T:0.03EU EA WA 836
rs1586331,2
A,C,F,H30930691(-) TTTAGG/TTGGGC 1 R/S mis14Minor allele frequency- T:0.09EU EA WA 390
rs6244531,2
C,F,H30842971(-) TAATCG/AAGAGC 1 -- ng51 ese38Minor allele frequency- A:0.01EU EA WA 838
rs341106611,2
C,F30881634(-) TGGAAA/GAGAAC 1 K/R mis15Minor allele frequency- G:0.02NA EU EA WA 496
rs2080691,2
A,C31106878(-) CATCTA/CATTTA 1 -- ng310--------
rs79314631,2
H31107540(+) tgtttT/Aaaaaa 1 -- ng314Minor allele frequency- A:0.00EU EA WA 418
rs116049451,2
H31107284(+) TATTAC/TTCATA 1 -- ng314Minor allele frequency- T:0.00EU EA WA 420
rs79477321,2
A,C,F,H30877719(+) CTGTCC/TTTTTT 1 K/K syn1 ese38Minor allele frequency- T:0.01EU EA WA 838
rs1638701,2
H30930658(+) TGGCCT/CGGCTT 1 P/P syn14Minor allele frequency- C:0.00EU EA WA 420
rs1638791,2
A,C,F,H,O30908250(+) TAATGT/CAAGTA 1 -- int17Minor allele frequency- C:0.45EU EA WA NA 552
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HapMap Linkage Disequilibrium images for DCDC5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 612321

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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4 PubMed articles for DCDC5 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 196296 HGNC: 24799 AceView: DCDC1 Ensembl:ENSG00000170959 euGenes: HUgn196296
ECgene: DCDC5 H-InvDB: DCDC5
(According to HUGE)
About This Section

HUGE: KIAA1493
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for DCDC5:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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