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Aliases for DCDC5 Gene

Aliases for DCDC5 Gene

  • Doublecortin Domain Containing 5 2 3
  • KIAA1493 4 6

External Ids for DCDC5 Gene

Previous GeneCards Identifiers for DCDC5 Gene

  • GC11M030809

Summaries for DCDC5 Gene

Entrez Gene Summary for DCDC5 Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found, but the full-length nature of some variants is not determined. [provided by RefSeq, Feb 2011]

GeneCards Summary for DCDC5 Gene

DCDC5 (Doublecortin Domain Containing 5) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC5 Gene

Genomics for DCDC5 Gene

Genomic Location for DCDC5 Gene

30,830,369 bp from pter
31,369,810 bp from pter
539,442 bases
Minus strand

Genomic View for DCDC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC5 Gene

Proteins for DCDC5 Gene

  • Protein details for DCDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublecortin domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B1AL47

    Protein attributes for DCDC5 Gene

    648 amino acids
    Molecular mass:
    72753 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=CAO03425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DCDC5 Gene

Proteomics data for DCDC5 Gene at MOPED

Post-translational modifications for DCDC5 Gene

No Post-translational modifications

Other Protein References for DCDC5 Gene

No data available for DME Specific Peptides for DCDC5 Gene

Domains for DCDC5 Gene

Protein Domains for DCDC5 Gene

Suggested Antigen Peptide Sequences for DCDC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6ZRR9
  • Contains 2 doublecortin domains.
genes like me logo Genes that share domains with DCDC5: view

No data available for Gene Families for DCDC5 Gene

Function for DCDC5 Gene

Phenotypes for DCDC5 Gene

GenomeRNAi human phenotypes for DCDC5:
genes like me logo Genes that share phenotypes with DCDC5: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DCDC5 Gene

Localization for DCDC5 Gene

Subcellular locations from

Jensen Localization Image for DCDC5 Gene COMPARTMENTS Subcellular localization image for DCDC5 gene
Compartment Confidence
cytosol 2
nucleus 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCDC5 Gene

Pathways for DCDC5 Gene

SuperPathways for DCDC5 Gene

No Data Available

Interacting Proteins for DCDC5 Gene

Gene Ontology (GO) - Biological Process for DCDC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC5: view

No data available for Pathways by source for DCDC5 Gene

Transcripts for DCDC5 Gene

mRNA/cDNA for DCDC5 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCDC5 Gene

Doublecortin domain containing 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -

Relevant External Links for DCDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCDC5 Gene

mRNA expression in normal human tissues for DCDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DCDC5 Gene

This gene is overexpressed in Amniocyte (52.4) and Platelet (10.1).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DCDC5 Gene

SOURCE GeneReport for Unigene cluster for DCDC5 Gene Hs.530438

genes like me logo Genes that share expressions with DCDC5: view

Expression partners for DCDC5 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCDC5 Gene

Orthologs for DCDC5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCDC5 35
  • 85.49 (n)
  • 80.05 (a)
DCDC1 36
  • 78 (a)
(Canis familiaris)
Mammalia LOC475957 35
  • 87.26 (n)
  • 82.99 (a)
DCDC1 36
  • 69 (a)
(Mus musculus)
Mammalia Dcdc5 35
  • 76.64 (n)
  • 67.14 (a)
Dcdc5 16
(Pan troglodytes)
Mammalia DCDC5 35
  • 99.38 (n)
  • 99.42 (a)
DCDC1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dcdc5 35
  • 74.3 (n)
  • 65.67 (a)
(Ornithorhynchus anatinus)
Mammalia DCDC1 36
  • 62 (a)
(Anolis carolinensis)
Reptilia DCDC1 36
  • 58 (a)
Species with no ortholog for DCDC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC5 Gene

Gene Tree for DCDC5 (if available)
Gene Tree for DCDC5 (if available)

Paralogs for DCDC5 Gene

Selected SIMAP similar genes for DCDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCDC5: view

No data available for Paralogs for DCDC5 Gene

Variants for DCDC5 Gene

Sequence variations from dbSNP and Humsavar for DCDC5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs151457 -- 30,969,557(+) gtttg(A/C)ggcag intron-variant
rs156398 -- 30,936,671(+) agtag(A/G)aacac intron-variant
rs156399 -- 30,934,400(+) gttat(A/G)gaagt intron-variant
rs158505 -- 30,959,701(-) TCTGG(A/G)TTATA intron-variant
rs158581 -- 30,974,350(-) aattt(G/T)gggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC5 Gene

Variant ID Type Subtype PubMed ID
nsv897173 CNV Loss 21882294
nsv897174 CNV Loss 21882294
nsv507588 CNV Insertion 20534489
esv2540017 CNV Loss 19546169
nsv513309 CNV Insertion 21212237
esv1245858 CNV Insertion 17803354
nsv897175 CNV Gain 21882294
essv17950 CNV CNV 17122850
nsv516888 CNV Loss 19592680
nsv897176 CNV Gain 21882294
nsv529004 CNV Loss 19592680

Relevant External Links for DCDC5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC5 Gene

Disorders for DCDC5 Gene

Relevant External Links for DCDC5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DCDC5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DCDC5 Gene

Publications for DCDC5 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 2 3
  4. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 48
  5. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3

Products for DCDC5 Gene

Sources for DCDC5 Gene

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