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Aliases for DCDC5 Gene

Aliases for DCDC5 Gene

  • Doublecortin Domain Containing 5 2
  • KIAA1493 4

External Ids for DCDC5 Gene

Previous GeneCards Identifiers for DCDC5 Gene

  • GC11M030809

Summaries for DCDC5 Gene

GeneCards Summary for DCDC5 Gene

DCDC5 (Doublecortin Domain Containing 5) is a Protein Coding gene. Diseases associated with DCDC5 include Iris Disease.

Additional gene information for DCDC5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC5 Gene

Genomics for DCDC5 Gene

Regulatory Elements for DCDC5 Gene

Enhancers for DCDC5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H030991 0.8 ENCODE 0.7 +0.2 184 1 SOX13 SAP130 ARID4B ZNF644 YY1 NFE2 HOMEZ MAFK NFE2L2 SOX5 MPPED2 DCDC5 GC11P030983
GH11H030983 0.6 ENCODE 0.4 +7.7 7701 2 SOX13 JUND GATA3 POLR2A USF2 SIN3A FOS MPPED2 GC11P030983 DCDC5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCDC5 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCDC5 Gene

30,863,603 bp from pter
30,992,686 bp from pter
129,084 bases
Minus strand

Genomic View for DCDC5 Gene

Genes around DCDC5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

No data available for RefSeq DNA sequence for DCDC5 Gene

Proteins for DCDC5 Gene

  • Protein details for DCDC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublecortin domain-containing protein 5
    Protein Accession:
    Secondary Accessions:
    • B1AL47

    Protein attributes for DCDC5 Gene

    648 amino acids
    Molecular mass:
    72753 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC87240.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305}; Sequence=CAO03425.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for DCDC5 Gene

Post-translational modifications for DCDC5 Gene

No Post-translational modifications

No data available for DME Specific Peptides for DCDC5 Gene

Domains & Families for DCDC5 Gene

Gene Families for DCDC5 Gene

Protein Domains for DCDC5 Gene

Suggested Antigen Peptide Sequences for DCDC5 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCDC5: view

No data available for UniProtKB/Swiss-Prot for DCDC5 Gene

Function for DCDC5 Gene

Phenotypes From GWAS Catalog for DCDC5 Gene

genes like me logo Genes that share phenotypes with DCDC5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCDC5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC5 Gene

Localization for DCDC5 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCDC5 gene
Compartment Confidence
nucleus 2
cytosol 2
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for DCDC5 Gene

Pathways & Interactions for DCDC5 Gene

SuperPathways for DCDC5 Gene

No Data Available

Interacting Proteins for DCDC5 Gene

Gene Ontology (GO) - Biological Process for DCDC5 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCDC5 Gene

Drugs & Compounds for DCDC5 Gene

No Compound Related Data Available

Transcripts for DCDC5 Gene

mRNA/cDNA for DCDC5 Gene

(0) Additional mRNA sequences :

Unigene Clusters for DCDC5 Gene

Doublecortin domain containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCDC5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -

Relevant External Links for DCDC5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCDC5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCDC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCDC5 Gene

This gene is overexpressed in Amniocyte (52.4) and Platelet (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCDC5 Gene

Protein tissue co-expression partners for DCDC5 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCDC5 Gene:


SOURCE GeneReport for Unigene cluster for DCDC5 Gene:


Evidence on tissue expression from TISSUES for DCDC5 Gene

  • Nervous system(4.1)
  • Kidney(3.5)
genes like me logo Genes that share expression patterns with DCDC5: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCDC5 Gene

Orthologs for DCDC5 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DCDC5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCDC5 33
  • 99.38 (n)
(Canis familiaris)
Mammalia LOC475957 33
  • 87.26 (n)
(Bos Taurus)
Mammalia DCDC5 33
  • 85.49 (n)
(Mus musculus)
Mammalia Dcdc5 33 16
  • 76.64 (n)
(Rattus norvegicus)
Mammalia Dcdc5 33
  • 74.3 (n)
Species where no ortholog for DCDC5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

No data available for Evolution for DCDC5 Gene

Paralogs for DCDC5 Gene

(2) SIMAP similar genes for DCDC5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCDC5: view

No data available for Paralogs for DCDC5 Gene

Variants for DCDC5 Gene

Structural Variations from Database of Genomic Variants (DGV) for DCDC5 Gene

Variant ID Type Subtype PubMed ID
dgv1088n100 CNV loss 25217958
esv1245858 CNV insertion 17803354
esv2540017 CNV loss 19546169
esv2759814 CNV loss 17122850
esv3411357 CNV insertion 20981092
esv3625821 CNV gain 21293372
nsv1035755 CNV gain 25217958
nsv1122602 CNV deletion 24896259
nsv1147322 CNV duplication 26484159
nsv473260 CNV novel sequence insertion 20440878
nsv480627 CNV novel sequence insertion 20440878
nsv507588 OTHER sequence alteration 20534489
nsv513309 CNV insertion 21212237
nsv516888 CNV loss 19592680
nsv529004 CNV loss 19592680
nsv553947 CNV gain 21841781
nsv553948 CNV loss 21841781

Relevant External Links for DCDC5 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Variation tolerance for DCDC5 Gene

Disorders for DCDC5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCDC5 Gene - From: HGMD and DISEASES

Disorder Aliases PubMed IDs
iris disease
  • iris diseases
- elite association - COSMIC cancer census association via MalaCards
Search DCDC5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCDC5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DCDC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCDC5 Gene

Publications for DCDC5 Gene

  1. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F … Genetic Factors for Osteoporosis (GEFOS) Consortium (Nature genetics 2009) 45 60
  2. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PMID: 17903299) Kathiresan S … Cupples LA (BMC medical genetics 2007) 45 60
  3. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 60
  4. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O … Bergmann S (BMC genomics 2006) 2 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 60

Products for DCDC5 Gene

Sources for DCDC5 Gene

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