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Aliases for DCDC2C Gene

Aliases for DCDC2C Gene

  • Doublecortin Domain Containing 2C 2 3 5
  • Doublecortin Domain Containing 2C Pseudogene 2

External Ids for DCDC2C Gene

Previous GeneCards Identifiers for DCDC2C Gene

  • GC00U922108
  • GC02U901141

Summaries for DCDC2C Gene

GeneCards Summary for DCDC2C Gene

DCDC2C (Doublecortin Domain Containing 2C) is a Protein Coding gene. An important paralog of this gene is DCDC2B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC2C Gene

Genomics for DCDC2C Gene

Genomic Location for DCDC2C Gene

Chromosome:
2
Start:
3,703,592 bp from pter
End:
3,847,411 bp from pter
Size:
143,820 bases
Orientation:
Plus strand

Genomic View for DCDC2C Gene

Genes around DCDC2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC2C Gene

No data available for Regulatory Elements for DCDC2C Gene

Proteins for DCDC2C Gene

  • Protein details for DCDC2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYV0-DCD2C_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 2C
    Protein Accession:
    A8MYV0

    Protein attributes for DCDC2C Gene

    Size:
    355 amino acids
    Molecular mass:
    40425 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCDC2C Gene

Proteomics data for DCDC2C Gene at MOPED

Post-translational modifications for DCDC2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCDC2C Gene

Domains & Families for DCDC2C Gene

Protein Domains for DCDC2C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCDC2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A8MYV0

UniProtKB/Swiss-Prot:

DCD2C_HUMAN :
  • Contains 2 doublecortin domains.
Domain:
  • Contains 2 doublecortin domains.
genes like me logo Genes that share domains with DCDC2C: view

No data available for Gene Families for DCDC2C Gene

Function for DCDC2C Gene

Phenotypes for DCDC2C Gene

genes like me logo Genes that share phenotypes with DCDC2C: view

Animal Models for DCDC2C Gene

MGI Knock Outs for DCDC2C:

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC2C Gene

Localization for DCDC2C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCDC2C Gene COMPARTMENTS Subcellular localization image for DCDC2C gene
Compartment Confidence
cytosol 2
nucleus 2
cytoskeleton 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCDC2C Gene

Pathways & Interactions for DCDC2C Gene

SuperPathways for DCDC2C Gene

No Data Available

Interacting Proteins for DCDC2C Gene

Gene Ontology (GO) - Biological Process for DCDC2C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCDC2C Gene

Drugs & Compounds for DCDC2C Gene

No Compound Related Data Available

Transcripts for DCDC2C Gene

mRNA/cDNA for DCDC2C Gene

(9) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC2C Gene

No ASD Table

Relevant External Links for DCDC2C Gene

GeneLoc Exon Structure for
DCDC2C
ECgene alternative splicing isoforms for
DCDC2C

Expression for DCDC2C Gene

mRNA expression in normal human tissues for DCDC2C Gene

mRNA differential expression in normal tissues according to GTEx for DCDC2C Gene

This gene is overexpressed in Testis (x29.1) and Nerve - Tibial (x6.5).
genes like me logo Genes that share expression patterns with DCDC2C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DCDC2C Gene

Orthologs for DCDC2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCDC2C 35
  • 99.07 (n)
  • 98.61 (a)
DCDC2C 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCDC2C 36
  • 68 (a)
OneToOne
DCDC2C 35
  • 82.2 (n)
  • 76.27 (a)
dog
(Canis familiaris)
Mammalia DCDC2C 35
  • 84.93 (n)
  • 77.1 (a)
DCDC2C 36
  • 47 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcdc2c 16
Dcdc2c 36
  • 63 (a)
OneToOne
Dcdc2c 35
  • 78.18 (n)
  • 69.09 (a)
oppossum
(Monodelphis domestica)
Mammalia DCDC2C 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC2C 36
  • 35 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcdc2c 35
  • 80.04 (n)
  • 74.93 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8501 36
  • 11 (a)
OneToMany
Species with no ortholog for DCDC2C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC2C Gene

ENSEMBL:
Gene Tree for DCDC2C (if available)
TreeFam:
Gene Tree for DCDC2C (if available)

Paralogs for DCDC2C Gene

Paralogs for DCDC2C Gene

(1) SIMAP similar genes for DCDC2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCDC2C: view

Variants for DCDC2C Gene

Sequence variations from dbSNP and Humsavar for DCDC2C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs357943 -- 3,727,528(+) CCCTC(A/G)TGGGC intron-variant
rs357944 -- 3,728,676(+) ACAAA(A/T)AAACC intron-variant, downstream-variant-500B
rs357957 -- 3,736,098(+) CTTTG(A/G)TTAAA intron-variant
rs357963 -- 3,760,387(-) gcaat(A/G)aacat intron-variant
rs357964 -- 3,760,369(-) catgt(A/G)tcttt intron-variant

Variation tolerance for DCDC2C Gene

Gene Damage Index Score: 6.90; 79.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCDC2C Gene

HapMap Linkage Disequilibrium report
DCDC2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCDC2C Gene

Disorders for DCDC2C Gene

Relevant External Links for DCDC2C

Genetic Association Database (GAD)
DCDC2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCDC2C

No disorders were found for DCDC2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCDC2C Gene

Publications for DCDC2C Gene

  1. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 48 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3
  4. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 3
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3

Products for DCDC2C Gene

Sources for DCDC2C Gene

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