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Aliases for DCDC2C Gene

Aliases for DCDC2C Gene

  • Doublecortin Domain Containing 2C 2 3 5
  • Doublecortin Domain Containing 2C Pseudogene 2

External Ids for DCDC2C Gene

Previous GeneCards Identifiers for DCDC2C Gene

  • GC00U922108
  • GC02U901141

Summaries for DCDC2C Gene

GeneCards Summary for DCDC2C Gene

DCDC2C (Doublecortin Domain Containing 2C) is a Protein Coding gene. An important paralog of this gene is DCDC2.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC2C Gene

Genomics for DCDC2C Gene

Regulatory Elements for DCDC2C Gene

Enhancers for DCDC2C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G003758 0.4 ENCODE 11.4 +55.9 55945 1.2 CEBPB DCDC2C LOC105373393 GC02M003908
GH02G003712 0.6 ENCODE 6.4 +9.3 9314 1.6 CEBPA HLF CEBPB CEBPG ATF2 NR2F2 DCDC2C LOC105373393 GC02M003908
GH02G003702 0.4 Ensembl 5.2 +0.3 276 1.9 EZH2 ALLC DCDC2C LOC105373393
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCDC2C on UCSC Golden Path with GeneCards custom track

Genomic Location for DCDC2C Gene

Chromosome:
2
Start:
3,703,592 bp from pter
End:
3,847,411 bp from pter
Size:
143,820 bases
Orientation:
Plus strand

Genomic View for DCDC2C Gene

Genes around DCDC2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC2C Gene

Proteins for DCDC2C Gene

  • Protein details for DCDC2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYV0-DCD2C_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 2C
    Protein Accession:
    A8MYV0

    Protein attributes for DCDC2C Gene

    Size:
    355 amino acids
    Molecular mass:
    40425 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCDC2C Gene

Post-translational modifications for DCDC2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC2C Gene

No data available for DME Specific Peptides for DCDC2C Gene

Domains & Families for DCDC2C Gene

Gene Families for DCDC2C Gene

Protein Domains for DCDC2C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCDC2C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCDC2C: view

No data available for UniProtKB/Swiss-Prot for DCDC2C Gene

Function for DCDC2C Gene

Phenotypes for DCDC2C Gene

genes like me logo Genes that share phenotypes with DCDC2C: view

Animal Models for DCDC2C Gene

MGI Knock Outs for DCDC2C:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC2C Gene

Localization for DCDC2C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCDC2C gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DCDC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with DCDC2C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCDC2C Gene

Pathways & Interactions for DCDC2C Gene

SuperPathways for DCDC2C Gene

No Data Available

Interacting Proteins for DCDC2C Gene

Gene Ontology (GO) - Biological Process for DCDC2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC2C: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC2C Gene

Drugs & Compounds for DCDC2C Gene

No Compound Related Data Available

Transcripts for DCDC2C Gene

mRNA/cDNA for DCDC2C Gene

(7) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC2C Gene

No ASD Table

Relevant External Links for DCDC2C Gene

GeneLoc Exon Structure for
DCDC2C
ECgene alternative splicing isoforms for
DCDC2C

Expression for DCDC2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCDC2C Gene

mRNA differential expression in normal tissues according to GTEx for DCDC2C Gene

This gene is overexpressed in Testis (x29.1) and Nerve - Tibial (x6.5).

NURSA nuclear receptor signaling pathways regulating expression of DCDC2C Gene:

DCDC2C
genes like me logo Genes that share expression patterns with DCDC2C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCDC2C Gene

Orthologs for DCDC2C Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC2C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCDC2C 34 35
  • 99.07 (n)
dog
(Canis familiaris)
Mammalia DCDC2C 34 35
  • 84.93 (n)
cow
(Bos Taurus)
Mammalia DCDC2C 34 35
  • 82.2 (n)
rat
(Rattus norvegicus)
Mammalia Dcdc2c 34
  • 80.04 (n)
mouse
(Mus musculus)
Mammalia Dcdc2c 34 16 35
  • 78.18 (n)
oppossum
(Monodelphis domestica)
Mammalia DCDC2C 35
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC2C 35
  • 35 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8501 35
  • 11 (a)
OneToMany
Species where no ortholog for DCDC2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC2C Gene

ENSEMBL:
Gene Tree for DCDC2C (if available)
TreeFam:
Gene Tree for DCDC2C (if available)

Paralogs for DCDC2C Gene

Paralogs for DCDC2C Gene

(1) SIMAP similar genes for DCDC2C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCDC2C: view

Variants for DCDC2C Gene

Sequence variations from dbSNP and Humsavar for DCDC2C Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000012832 -- 3,747,170(+) CATGT(A/G)TGTTC intron-variant
rs1000025294 -- 3,810,153(+) AGATC(C/T)TTGAG intron-variant
rs1000034565 -- 3,755,492(+) ACACA(A/G)GAGTA intron-variant
rs1000048449 -- 3,726,793(+) AGACC(A/C)CCTCG intron-variant
rs1000102758 -- 3,791,191(+) AATAA(C/T)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC2C Gene

Variant ID Type Subtype PubMed ID
dgv1850n106 CNV deletion 24896259
dgv2047e59 CNV duplication 20981092
dgv3702n100 CNV gain 25217958
dgv3703n100 CNV loss 25217958
dgv583e201 CNV deletion 23290073
esv1004556 CNV deletion 20482838
esv1008461 CNV deletion 20482838
esv1340410 CNV deletion 17803354
esv1348299 CNV deletion 17803354
esv1568450 CNV deletion 17803354
esv1607144 CNV deletion 17803354
esv1753884 CNV deletion 17803354
esv1775252 CNV deletion 17803354
esv2055557 CNV deletion 18987734
esv2163054 CNV deletion 18987734
esv2185351 CNV deletion 18987734
esv2482665 CNV deletion 19546169
esv2607811 CNV deletion 19546169
esv2660453 CNV deletion 23128226
esv2668654 CNV deletion 23128226
esv2670253 CNV deletion 23128226
esv2719528 CNV deletion 23290073
esv2719530 CNV deletion 23290073
esv2719532 CNV deletion 23290073
esv2719534 CNV deletion 23290073
esv2719535 CNV deletion 23290073
esv2719536 CNV deletion 23290073
esv2719537 CNV deletion 23290073
esv2719538 CNV deletion 23290073
esv2743354 CNV deletion 23290073
esv275260 CNV gain+loss 21479260
esv2759019 CNV gain 17122850
esv2762239 CNV gain 21179565
esv2763276 CNV gain+loss 21179565
esv2777 CNV loss 18987735
esv2845791 CNV deletion 24192839
esv3008670 CNV deletion 24192839
esv3343878 CNV duplication 20981092
esv3551733 CNV deletion 23714750
esv3589668 CNV loss 21293372
esv4287 CNV loss 18987735
esv4379 CNV loss 18987735
esv4544 CNV loss 18987735
esv5118 CNV loss 18987735
nsv1004469 CNV gain 25217958
nsv1007039 CNV gain 25217958
nsv1008961 CNV loss 25217958
nsv1013223 CNV gain 25217958
nsv1069847 CNV deletion 25765185
nsv1115554 CNV duplication 24896259
nsv1115555 CNV duplication 24896259
nsv1121561 CNV deletion 24896259
nsv1125624 CNV deletion 24896259
nsv1129979 CNV deletion 24896259
nsv1135534 CNV deletion 24896259
nsv1146744 CNV duplication 26484159
nsv214960 CNV deletion 16902084
nsv468961 CNV gain 19166990
nsv506993 OTHER sequence alteration 20534489
nsv511763 CNV loss 21212237
nsv580822 CNV gain 21841781
nsv580825 CNV gain 21841781
nsv821189 CNV duplication 20802225
nsv828175 CNV gain 20364138
nsv954753 CNV deletion 24416366
nsv999394 CNV gain 25217958

Variation tolerance for DCDC2C Gene

Gene Damage Index Score: 6.90; 79.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCDC2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCDC2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC2C Gene

Disorders for DCDC2C Gene

Relevant External Links for DCDC2C

Genetic Association Database (GAD)
DCDC2C
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCDC2C

No disorders were found for DCDC2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCDC2C Gene

Publications for DCDC2C Gene

  1. Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia. (PMID: 21490949) Sim X. … Tai E.S. (PLoS Genet. 2011) 3 46 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  4. Genome-wide association study of lung function decline in adults with and without asthma. (PMID: 22424883) Imboden M. … Probst-Hensch N.M. (J. Allergy Clin. Immunol. 2012) 46 64
  5. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3 64

Products for DCDC2C Gene

Sources for DCDC2C Gene

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