Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCDC2B Gene

Aliases for DCDC2B Gene

  • Doublecortin Domain Containing 2B 2 3 5

External Ids for DCDC2B Gene

Previous GeneCards Identifiers for DCDC2B Gene

  • GC01P032447
  • GC01P032675
  • GC01P030791

Summaries for DCDC2B Gene

Entrez Gene Summary for DCDC2B Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCDC2B Gene

DCDC2B (Doublecortin Domain Containing 2B) is a Protein Coding gene. Diseases associated with DCDC2B include Deafness, Autosomal Recessive 66. An important paralog of this gene is DCDC2.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC2B Gene

Genomics for DCDC2B Gene

Regulatory Elements for DCDC2B Gene

Enhancers for DCDC2B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G032988 2.1 FANTOM5 Ensembl ENCODE dbSUPER 18.3 +782.2 782185 6.6 HDGF PKNOX1 ARNT ZFP64 SIN3A YBX1 ZNF766 FOS KLF13 DEK RNF19B ZBTB8B EIF3I DCDC2B ENSG00000239670 KPNA6 TSSK3 AK2 AZIN2 MTMR9LP
GH01G031711 2 FANTOM5 Ensembl ENCODE dbSUPER 14.1 -495.3 -495288 4.8 CREB3L1 AGO1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC ADGRB2 ENSG00000224066 SNRNP40 DCDC2B TSSK3 IQCC PEF1 ENSG00000235790 KPNA6 EIF3I
GH01G032141 1.2 Ensembl ENCODE 21.1 -66.4 -66374 2.2 ZNF493 ZFP64 ZNF133 ARID4B SIN3A KLF7 REST ZNF623 ZNF518A ZNF292 SNRNP40 EIF3I ENSG00000229447 KPNA6 DCDC2B CCDC28B IQCC TSSK3 ENSG00000224066 TMEM234
GH01G032350 1.5 ENCODE dbSUPER 14.2 +143.6 143637 4.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF548 TSSK3 EIF3I KPNA6 ENSG00000224066 DCDC2B IQCC ENSG00000235790 LOC105378629 FAM229A
GH01G031951 2.1 FANTOM5 Ensembl ENCODE dbSUPER 10 -253.0 -253024 9.1 CREB3L1 DMAP1 YBX1 YY1 TBX21 MEF2D GLIS1 RCOR2 NBN NR2C1 IQCC ENSG00000224066 SNRNP40 KHDRBS1 ENSG00000235790 LOC105378626 DCDC2B MTMR9LP PTP4A2 TMEM234
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCDC2B on UCSC Golden Path with GeneCards custom track

Genomic Location for DCDC2B Gene

Chromosome:
1
Start:
32,209,094 bp from pter
End:
32,216,196 bp from pter
Size:
7,103 bases
Orientation:
Plus strand

Genomic View for DCDC2B Gene

Genes around DCDC2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC2B Gene

Proteins for DCDC2B Gene

  • Protein details for DCDC2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VCK2-DCD2B_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 2B
    Protein Accession:
    A2VCK2
    Secondary Accessions:
    • B7ZBC6

    Protein attributes for DCDC2B Gene

    Size:
    349 amino acids
    Molecular mass:
    37665 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCDC2B Gene

Post-translational modifications for DCDC2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DCDC2B
  • Santa Cruz Biotechnology (SCBT) Antibodies for DCDC2B

No data available for DME Specific Peptides for DCDC2B Gene

Domains & Families for DCDC2B Gene

Gene Families for DCDC2B Gene

Protein Domains for DCDC2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCDC2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCDC2B: view

No data available for UniProtKB/Swiss-Prot for DCDC2B Gene

Function for DCDC2B Gene

Gene Ontology (GO) - Molecular Function for DCDC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCDC2B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC2B Gene

Localization for DCDC2B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCDC2B gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCDC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with DCDC2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCDC2B Gene

Pathways & Interactions for DCDC2B Gene

SuperPathways for DCDC2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCDC2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC2B: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC2B Gene

Transcripts for DCDC2B Gene

mRNA/cDNA for DCDC2B Gene

(3) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCDC2B Gene

Doublecortin domain containing 2B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC2B Gene

No ASD Table

Relevant External Links for DCDC2B Gene

GeneLoc Exon Structure for
DCDC2B
ECgene alternative splicing isoforms for
DCDC2B

Expression for DCDC2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCDC2B Gene

mRNA differential expression in normal tissues according to GTEx for DCDC2B Gene

This gene is overexpressed in Fallopian Tube (x6.0), Cervix - Endocervix (x4.9), and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for DCDC2B Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCDC2B Gene



Protein tissue co-expression partners for DCDC2B Gene

NURSA nuclear receptor signaling pathways regulating expression of DCDC2B Gene:

DCDC2B

SOURCE GeneReport for Unigene cluster for DCDC2B Gene:

Hs.424588
genes like me logo Genes that share expression patterns with DCDC2B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCDC2B Gene

Orthologs for DCDC2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCDC2B 34 35
  • 99.43 (n)
cow
(Bos Taurus)
Mammalia DCDC2B 34 35
  • 86.41 (n)
dog
(Canis familiaris)
Mammalia DCDC2B 34 35
  • 84.22 (n)
rat
(Rattus norvegicus)
Mammalia Dcdc2b 34
  • 82 (n)
mouse
(Mus musculus)
Mammalia Dcdc2b 34 16 35
  • 79.14 (n)
oppossum
(Monodelphis domestica)
Mammalia DCDC2B 35
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC2B 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCDC2B 35
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC2B 35
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcdc2b 34
  • 51.78 (n)
zebrafish
(Danio rerio)
Actinopterygii dcdc2b 35
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8501 35
  • 15 (a)
OneToMany
Species where no ortholog for DCDC2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCDC2B Gene

ENSEMBL:
Gene Tree for DCDC2B (if available)
TreeFam:
Gene Tree for DCDC2B (if available)

Paralogs for DCDC2B Gene

Paralogs for DCDC2B Gene

(1) SIMAP similar genes for DCDC2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCDC2B: view

Variants for DCDC2B Gene

Sequence variations from dbSNP and Humsavar for DCDC2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000142594 -- 32,210,524(+) AAAAG(-/A)AAAAA intron-variant, upstream-variant-2KB
rs1000174145 -- 32,210,326(+) CATCT(-/AAAAAAAAAAAA)AAAAA intron-variant, upstream-variant-2KB
rs1000506821 -- 32,208,946(+) GGGAT(A/G)AAACC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime
rs1000713531 -- 32,216,362(+) TTTCC(C/T)GCATC intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1000992739 -- 32,209,678(+) TGGAC(C/G)CCCTA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DCDC2B Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV insertion 18451855

Variation tolerance for DCDC2B Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCDC2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCDC2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC2B Gene

Disorders for DCDC2B Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCDC2B Gene - From: DISEASES

Disorder Aliases PubMed IDs
deafness, autosomal recessive 66
  • autosomal recessive nonsyndromic deafness 66
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DCDC2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCDC2B
genes like me logo Genes that share disorders with DCDC2B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCDC2B Gene

Publications for DCDC2B Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  2. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3 64
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 3 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for DCDC2B Gene

Sources for DCDC2B Gene

Content
Loading form....