DCDC2B Gene
protein-coding GIFtS: 35
GCID: GC01P032675
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doublecortin domain containing 2B
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Aliases
for DCDC2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Doublecortin Domain Containing 2B1 2 | | Doublecortin Domain-Containing Protein 2B2 |
Export aliases for DCDC2B gene to outside databasesPrevious GC identifers: GC01P032447 GC01P030791 |
Summaries
for DCDC2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DCDC2B:
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortindomains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization.(provided by RefSeq, Sep 2010)
|
Genomic Views
for DCDC2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCDC2B gene promoter:
Sox5 Pbx1a HSF1 (long) STAT5A E4BP4 E47 Pax-3 Hand1 HSF1short STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCDC2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCDC2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p35.1 Ensembl cytogenetic band: 1p35.1 HGNC cytogenetic band: 1p35.1DCDC2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P032675: view genomic region
(about GC identifiers)
Start:
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32,674,695 bp from pter |
End:
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32,681,797 bp from pter |
Size:
|
7,103 bases |
Orientation:
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plus strand |
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Proteins
for DCDC2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCD2B_HUMAN, A2VCK2 (See
protein sequence)Recommended Name: Doublecortin domain-containing protein 2B Size: 349 amino acids; 37665 Da
Secondary accessions: B7ZBC6Explore the universe of human proteins at neXtProt for DCDC2B: NX_A2VCK2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A2VCK2
DCDC2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001092904.1
ENSEMBL proteins: ENSP00000386870
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
DCDC2B for ontologies About GeneDecksing
DCDC2B Antibody Products:
Assay Products for DCDC2B: |
Protein
Domains /
Families
for DCDC2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCDC2B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A2VCK2ProtoNet protein and cluster: A2VCK2 UniProtKB/Swiss-Prot: DCD2B_HUMAN, A2VCK2Similarity: Contains 2 doublecortin domains |
Function
for DCDC2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCDC2B |
|
Pathways & Interactions
for DCDC2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCDC2B
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035556 | intracellular signal transduction |
IEA | -- |
DCDC2B for ontologies About GeneDecksing
|
Drugs & Compounds
for DCDC2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCDC2B
Search CenterWatch for drugs/clinical trials and news about DCDC2B / DCD2B
|
Transcripts
for DCDC2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCDC2B gene: NM_001099434.1 Unigene Cluster for DCDC2B: Doublecortin domain containing 2B Hs.424588 [show with all ESTs]Unigene Representative Sequence: NM_0010994342 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000409358(uc001bun.2) ENST00000487056
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCDC2B (NM_001099434) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCDC2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCDC2B |
Additional cDNA sequence: BC128073.1 3 DOTS entries: DT.121372620 DT.97826916 DT.121372637
GeneLoc Exon Structure
|
Expression
for DCDC2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCDC2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCACCCTGT
About this image
See DCDC2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCDC2B
SOURCE GeneReport for Unigene cluster: Hs.424588
SABiosciences Custom PCR Arrays for DCDC2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCDC2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DCDC2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCDC2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCDC2B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCDC2B |
Orthologs
for DCDC2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for DCDC2B gene from 3/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DCDC2B1 |
doublecortin domain containing 2B |
62.77(n)
59.9(a) |
|
770841 XM_001234163.2 XP_001234164.1 |
lizard
(Anolis carolinensis) |
Reptilia |
DCDC2B6 |
-- |
41(a) |
1 ↔ 1 |
GL343706.1(116497-126886) |
zebrafish
(Danio rerio) |
Actinopterygii |
dcdc2b6 |
doublecortin domain containing 2B |
29(a) |
possible ortholog |
13(33527789-33538360) |
ENSEMBL Gene Tree for DCDC2B (if available)
TreeFam Gene Tree for DCDC2B (if available) |
Paralogs
for DCDC2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DCDC2B gene
- DCDC22 DCDC2C2
1 SIMAP similar gene for DCDC2B using alignment to 1 protein entry: DCD2B_HUMAN:DCDC2
DCDC2B for paralogs About GeneDecksing
|
Genomic Variants
for DCDC2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCDC2B (32674695 - 32681797 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DCDC2B: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCDC2B |
|
Disorders
/ Diseases
for DCDC2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DCDC2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCDC2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with DCDC2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The doublecortin gene family and disorders of neurona l structure. (PubMed id 20236041)1 Dijkmans T.F....Vreugdenhil E. (2010)
- The evolving doublecortin (DCX) superfamily. (PubMed id 16869982)1 Reiner O....Bergmann S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for DCDC2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCDC2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCDC2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCDC2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCDC2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCDC2B gene:
Search GeneIP for patents involving DCDC2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCDC2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCDC2B |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCDC2B |
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