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Aliases for DCDC2B Gene

Aliases for DCDC2B Gene

  • Doublecortin Domain Containing 2B 2 3 5

External Ids for DCDC2B Gene

Previous GeneCards Identifiers for DCDC2B Gene

  • GC01P032447
  • GC01P032675
  • GC01P030791

Summaries for DCDC2B Gene

Entrez Gene Summary for DCDC2B Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCDC2B Gene

DCDC2B (Doublecortin Domain Containing 2B) is a Protein Coding gene. An important paralog of this gene is DCDC2C.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC2B Gene

Genomics for DCDC2B Gene

Regulatory Elements for DCDC2B Gene

Enhancers for DCDC2B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCDC2B on UCSC Golden Path with GeneCards custom track

Genomic Location for DCDC2B Gene

Chromosome:
1
Start:
32,209,094 bp from pter
End:
32,216,196 bp from pter
Size:
7,103 bases
Orientation:
Plus strand

Genomic View for DCDC2B Gene

Genes around DCDC2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC2B Gene

Proteins for DCDC2B Gene

  • Protein details for DCDC2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A2VCK2-DCD2B_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 2B
    Protein Accession:
    A2VCK2
    Secondary Accessions:
    • B7ZBC6

    Protein attributes for DCDC2B Gene

    Size:
    349 amino acids
    Molecular mass:
    37665 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCDC2B Gene

Proteomics data for DCDC2B Gene at MOPED

Post-translational modifications for DCDC2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCDC2B Gene

Domains & Families for DCDC2B Gene

Protein Domains for DCDC2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCDC2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A2VCK2

UniProtKB/Swiss-Prot:

DCD2B_HUMAN :
  • Contains 2 doublecortin domains.
Domain:
  • Contains 2 doublecortin domains.
genes like me logo Genes that share domains with DCDC2B: view

No data available for Gene Families for DCDC2B Gene

Function for DCDC2B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC2B Gene

Localization for DCDC2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCDC2B Gene COMPARTMENTS Subcellular localization image for DCDC2B gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCDC2B Gene

Pathways & Interactions for DCDC2B Gene

SuperPathways for DCDC2B Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCDC2B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCDC2B Gene

Drugs & Compounds for DCDC2B Gene

No Compound Related Data Available

Transcripts for DCDC2B Gene

mRNA/cDNA for DCDC2B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCDC2B Gene

Doublecortin domain containing 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC2B Gene

No ASD Table

Relevant External Links for DCDC2B Gene

GeneLoc Exon Structure for
DCDC2B
ECgene alternative splicing isoforms for
DCDC2B

Expression for DCDC2B Gene

mRNA expression in normal human tissues for DCDC2B Gene

mRNA differential expression in normal tissues according to GTEx for DCDC2B Gene

This gene is overexpressed in Fallopian Tube (x6.0), Cervix - Endocervix (x4.9), and Testis (x4.3).

Protein differential expression in normal tissues from HIPED for DCDC2B Gene

This gene is overexpressed in Cerebrospinal fluid (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCDC2B Gene



SOURCE GeneReport for Unigene cluster for DCDC2B Gene Hs.424588

genes like me logo Genes that share expression patterns with DCDC2B: view

Protein tissue co-expression partners for DCDC2B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DCDC2B Gene

Orthologs for DCDC2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC2B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCDC2B 35
  • 86.41 (n)
  • 82.11 (a)
DCDC2B 36
  • 62 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCDC2B 35
  • 84.22 (n)
  • 77.81 (a)
DCDC2B 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcdc2b 35
  • 79.14 (n)
  • 74.13 (a)
Dcdc2b 16
Dcdc2b 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCDC2B 35
  • 99.43 (n)
  • 99.43 (a)
DCDC2B 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcdc2b 35
  • 82 (n)
  • 74.25 (a)
oppossum
(Monodelphis domestica)
Mammalia DCDC2B 36
  • 61 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC2B 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCDC2B 36
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC2B 36
  • 37 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcdc2b 35
  • 51.78 (n)
  • 44.97 (a)
zebrafish
(Danio rerio)
Actinopterygii dcdc2b 36
  • 28 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8501 36
  • 15 (a)
OneToMany
Species with no ortholog for DCDC2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCDC2B Gene

ENSEMBL:
Gene Tree for DCDC2B (if available)
TreeFam:
Gene Tree for DCDC2B (if available)

Paralogs for DCDC2B Gene

Paralogs for DCDC2B Gene

(1) SIMAP similar genes for DCDC2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCDC2B: view

Variants for DCDC2B Gene

Structural Variations from Database of Genomic Variants (DGV) for DCDC2B Gene

Variant ID Type Subtype PubMed ID
nsv300 CNV Insertion 18451855

Variation tolerance for DCDC2B Gene

Residual Variation Intolerance Score: 83.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCDC2B Gene

HapMap Linkage Disequilibrium report
DCDC2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DCDC2B Gene

Disorders for DCDC2B Gene

Relevant External Links for DCDC2B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCDC2B

No disorders were found for DCDC2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCDC2B Gene

Publications for DCDC2B Gene

  1. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 67
  2. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for DCDC2B Gene

Sources for DCDC2B Gene

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