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Aliases for DCDC2 Gene

Aliases for DCDC2 Gene

  • Doublecortin Domain Containing 2 2 3
  • RU2 3 4 6
  • KIAA1154 4 6
  • Doublecortin Domain-Containing Protein 2 3
  • Protein RU2S 4
  • DCDC2A 3
  • NPHP19 3
  • RU2S 3

External Ids for DCDC2 Gene

Previous GeneCards Identifiers for DCDC2 Gene

  • GC06M024233
  • GC06M024254
  • GC06M024277

Summaries for DCDC2 Gene

Entrez Gene Summary for DCDC2 Gene

  • This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for DCDC2 Gene

DCDC2 (Doublecortin Domain Containing 2) is a Protein Coding gene. Diseases associated with DCDC2 include nephronophthisis 19 and writing disorder. An important paralog of this gene is DCDC2B.

UniProtKB/Swiss-Prot for DCDC2 Gene

  • May be involved in neuronal migration during development of the cerebral neocortex.

Gene Wiki entry for DCDC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC2 Gene

Genomics for DCDC2 Gene

Regulatory Elements for DCDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCDC2 Gene

24,171,755 bp from pter
24,383,292 bp from pter
211,538 bases
Minus strand

Genomic View for DCDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC2 Gene

Proteins for DCDC2 Gene

  • Protein details for DCDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublecortin domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • Q5VTR8
    • Q5VTR9
    • Q86W35
    • Q9UFD1
    • Q9UHG1
    • Q9ULR6

    Protein attributes for DCDC2 Gene

    476 amino acids
    Molecular mass:
    52834 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAB61371.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCDC2 Gene

    Alternative splice isoforms for DCDC2 Gene


neXtProt entry for DCDC2 Gene

Proteomics data for DCDC2 Gene at MOPED

Post-translational modifications for DCDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC2 Gene

Antibody Products

No data available for DME Specific Peptides for DCDC2 Gene

Domains for DCDC2 Gene

Protein Domains for DCDC2 Gene


Suggested Antigen Peptide Sequences for DCDC2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 doublecortin domains.
  • Contains 2 doublecortin domains.
genes like me logo Genes that share domains with DCDC2: view

No data available for Gene Families for DCDC2 Gene

Function for DCDC2 Gene

Molecular function for DCDC2 Gene

UniProtKB/Swiss-Prot Function:
May be involved in neuronal migration during development of the cerebral neocortex.

Gene Ontology (GO) - Molecular Function for DCDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21698230
genes like me logo Genes that share ontologies with DCDC2: view

Phenotypes for DCDC2 Gene

MGI mutant phenotypes for DCDC2:
inferred from 2 alleles
GenomeRNAi human phenotypes for DCDC2:
genes like me logo Genes that share phenotypes with DCDC2: view

Animal Models for DCDC2 Gene

MGI Knock Outs for DCDC2:

Animal Model Products

CRISPR Products

miRNA for DCDC2 Gene

miRTarBase miRNAs that target DCDC2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCDC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DCDC2 Gene

Localization for DCDC2 Gene

Subcellular locations from

Jensen Localization Image for DCDC2 Gene COMPARTMENTS Subcellular localization image for DCDC2 gene
Compartment Confidence
mitochondrion 3
peroxisome 2
cytoskeleton 1
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DCDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21698230
GO:0072372 primary cilium IDA 21698230
genes like me logo Genes that share ontologies with DCDC2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCDC2 Gene

Pathways for DCDC2 Gene

SuperPathways for DCDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration NAS 16278297
GO:0006968 cellular defense response TAS 10601354
GO:0008542 visual learning IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0045880 positive regulation of smoothened signaling pathway IMP 21698230
genes like me logo Genes that share ontologies with DCDC2: view

No data available for Pathways by source for DCDC2 Gene

Transcripts for DCDC2 Gene

Unigene Clusters for DCDC2 Gene

Doublecortin domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCDC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC2 Gene

No ASD Table

Relevant External Links for DCDC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCDC2 Gene

mRNA expression in normal human tissues for DCDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCDC2 Gene

This gene is overexpressed in Kidney - Cortex (16.8) and Pancreas (10.9).

Protein differential expression in normal tissues for DCDC2 Gene

This gene is overexpressed in Islet of Langerhans (27.8), Pancreas (20.8), Amniocyte (12.1), and Kidney (8.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCDC2 Gene

SOURCE GeneReport for Unigene cluster for DCDC2 Gene Hs.61345

mRNA Expression by UniProt/SwissProt for DCDC2 Gene

Tissue specificity: Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus.
genes like me logo Genes that share expressions with DCDC2: view

Expression partners for DCDC2 Gene

* - Elite partner

Primer Products

In Situ Assay Products

Orthologs for DCDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCDC2 35
  • 86.95 (n)
  • 84.89 (a)
DCDC2 36
  • 84 (a)
(Canis familiaris)
Mammalia DCDC2 35
  • 87.32 (n)
  • 86.34 (a)
DCDC2 36
  • 87 (a)
(Mus musculus)
Mammalia Dcdc2a 35
  • 82.81 (n)
  • 83.37 (a)
Dcdc2a 16
Dcdc2a 36
  • 83 (a)
(Rattus norvegicus)
Mammalia Dcdc2 35
  • 83.58 (n)
  • 83.16 (a)
(Monodelphis domestica)
Mammalia DCDC2 36
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia DCDC2 36
  • 68 (a)
(Pan troglodytes)
Mammalia DCDC2 36
  • 100 (a)
(Gallus gallus)
Aves DCDC2 35
  • 69.16 (n)
  • 63.89 (a)
DCDC2 36
  • 59 (a)
(Anolis carolinensis)
Reptilia DCDC2 36
  • 61 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcdc2 35
  • 66.39 (n)
  • 67.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52970 35
(Danio rerio)
Actinopterygii dcdc2b 35
  • 53.71 (n)
  • 47.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8501 36
  • 20 (a)
Species with no ortholog for DCDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCDC2 Gene

Gene Tree for DCDC2 (if available)
Gene Tree for DCDC2 (if available)

Paralogs for DCDC2 Gene

Paralogs for DCDC2 Gene

(2) SIMAP similar genes for DCDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCDC2: view

Variants for DCDC2 Gene

Sequence variations from dbSNP and Humsavar for DCDC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6922811 -- 24,362,189(+) aattg(C/T)atatt intron-variant
rs6922164 -- 24,260,277(+) GTTCC(C/T)ACCTC intron-variant
rs6922023 -- 24,347,889(+) AAATC(A/G)GAATA intron-variant
rs6922004 -- 24,290,370(+) ATTTC(A/C)TGGAG intron-variant
rs6921861 -- 24,225,068(+) GCAAT(A/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC2 Gene

Variant ID Type Subtype PubMed ID
esv1324202 CNV Insertion 17803354
esv2456318 CNV Insertion 19546169
nsv512869 CNV Insertion 21212237
nsv511339 CNV Loss 21212237
dgv1081e199 CNV Deletion 23128226
nsv511857 CNV Loss 21212237
dgv1003n67 CNV Loss 20364138
esv23337 CNV Loss 19812545
esv2731711 CNV Deletion 23290073
esv9426 CNV Loss 19470904
esv2671001 CNV Deletion 23128226
esv32656 CNV Loss 17666407
esv33852 CNV Loss 17666407
esv33412 CNV Loss 17666407
esv269112 CNV Insertion 20981092

Relevant External Links for DCDC2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC2 Gene

Disorders for DCDC2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for DCDC2 Gene in MalaCards »

(3) Diseases for DCDC2 Gene


  • Dyslexia 2 (DYX2) [MIM:600202]: A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. {ECO:0000269 PubMed:16278297}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for DCDC2 Gene

Relevant External Links for DCDC2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DCDC2: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for DCDC2 Gene

Publications for DCDC2 Gene

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 3 4
  2. A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription. (PMID: 10601354) Van den Eynde B.J. … Boon T. (J. Exp. Med. 1999) 2 3 4
  3. Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample. (PMID: 19018237) Ludwig K.U. … Hoffmann P. (Psychiatr. Genet. 2008) 3 23 48
  4. Strong genetic evidence of DCDC2 as a susceptibility gene for dyslexia. (PMID: 16385449) Schumacher J. … Kere J. (Am. J. Hum. Genet. 2006) 3 48
  5. DCDC2 is associated with reading disability and modulates neuronal development in the brain. (PMID: 16278297) Meng H. … Gruen J.R. (Proc. Natl. Acad. Sci. U.S.A. 2005) 3 4

Products for DCDC2 Gene

Sources for DCDC2 Gene

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