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Aliases for DCDC2 Gene

Aliases for DCDC2 Gene

  • Doublecortin Domain Containing 2 2 3
  • Ru2 3 4
  • Protein RU2S 4
  • KIAA1154 4
  • DCDC2A 3
  • DFNB66 3
  • NPHP19 3
  • RU2S 3

External Ids for DCDC2 Gene

Previous GeneCards Identifiers for DCDC2 Gene

  • GC06M024233
  • GC06M024254
  • GC06M024277

Summaries for DCDC2 Gene

Entrez Gene Summary for DCDC2 Gene

  • This gene encodes a doublecortin domain-containing family member. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. This family member is thought to function in neuronal migration where it may affect the signaling of primary cilia. Mutations in this gene have been associated with reading disability (RD) type 2, also referred to as developmental dyslexia. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2013]

GeneCards Summary for DCDC2 Gene

DCDC2 (Doublecortin Domain Containing 2) is a Protein Coding gene. Diseases associated with DCDC2 include nephronophthisis 19 and deafness, autosomal recessive 66. An important paralog of this gene is DCDC2B.

UniProtKB/Swiss-Prot for DCDC2 Gene

  • Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex.

Gene Wiki entry for DCDC2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC2 Gene

Genomics for DCDC2 Gene

Regulatory Elements for DCDC2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCDC2 Gene

Chromosome:
6
Start:
24,171,755 bp from pter
End:
24,383,292 bp from pter
Size:
211,538 bases
Orientation:
Minus strand

Genomic View for DCDC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCDC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC2 Gene

Proteins for DCDC2 Gene

  • Protein details for DCDC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHG0-DCDC2_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 2
    Protein Accession:
    Q9UHG0
    Secondary Accessions:
    • Q5VTR8
    • Q5VTR9
    • Q86W35
    • Q9UFD1
    • Q9UHG1
    • Q9ULR6

    Protein attributes for DCDC2 Gene

    Size:
    476 amino acids
    Molecular mass:
    52834 Da
    Quaternary structure:
    • Interacts with DVL1, DVL2 and DVL3.
    SequenceCaution:
    • Sequence=CAB61371.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCDC2 Gene

    Alternative splice isoforms for DCDC2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCDC2 Gene

Proteomics data for DCDC2 Gene at MOPED

Post-translational modifications for DCDC2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC2 Gene

Antibody Products

No data available for DME Specific Peptides for DCDC2 Gene

Domains & Families for DCDC2 Gene

Protein Domains for DCDC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCDC2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHG0

UniProtKB/Swiss-Prot:

DCDC2_HUMAN :
  • Contains 2 doublecortin domains.
Domain:
  • Contains 2 doublecortin domains.
genes like me logo Genes that share domains with DCDC2: view

No data available for Gene Families for DCDC2 Gene

Function for DCDC2 Gene

Molecular function for DCDC2 Gene

UniProtKB/Swiss-Prot Function:
Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex.

Gene Ontology (GO) - Molecular Function for DCDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21698230
genes like me logo Genes that share ontologies with DCDC2: view

Phenotypes for DCDC2 Gene

genes like me logo Genes that share phenotypes with DCDC2: view

Animal Models for DCDC2 Gene

MGI Knock Outs for DCDC2:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCDC2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DCDC2 Gene

Localization for DCDC2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCDC2 Gene

Cytoplasm, cytoskeleton, cilium axoneme. Note=Localizes to the ciliary axoneme and to mitotic spindle fibers in a cell-cycle-dependent manner. {ECO:0000269 PubMed:25557784}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCDC2 Gene COMPARTMENTS Subcellular localization image for DCDC2 gene
Compartment Confidence
cytoskeleton 3
nucleus 1

Gene Ontology (GO) - Cellular Components for DCDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 21698230
GO:0005856 cytoskeleton IEA --
GO:0005930 axoneme IDA 25557784
GO:0072372 primary cilium IDA 21698230
genes like me logo Genes that share ontologies with DCDC2: view

Pathways & Interactions for DCDC2 Gene

SuperPathways for DCDC2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCDC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration NAS 16278297
GO:0006968 cellular defense response TAS 10601354
GO:0008542 visual learning IEA --
GO:0030111 regulation of Wnt signaling pathway IMP 25557784
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC2: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC2 Gene

Drugs & Compounds for DCDC2 Gene

No Compound Related Data Available

Transcripts for DCDC2 Gene

Unigene Clusters for DCDC2 Gene

Doublecortin domain containing 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCDC2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC2 Gene

No ASD Table

Relevant External Links for DCDC2 Gene

GeneLoc Exon Structure for
DCDC2
ECgene alternative splicing isoforms for
DCDC2

Expression for DCDC2 Gene

mRNA expression in normal human tissues for DCDC2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCDC2 Gene

This gene is overexpressed in Kidney - Cortex (x16.8) and Pancreas (x10.9).

Protein differential expression in normal tissues from HIPED for DCDC2 Gene

This gene is overexpressed in Islet of Langerhans (27.8), Pancreas (20.8), Amniocyte (12.1), and Kidney (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCDC2 Gene



SOURCE GeneReport for Unigene cluster for DCDC2 Gene Hs.61345

mRNA Expression by UniProt/SwissProt for DCDC2 Gene

Q9UHG0-DCDC2_HUMAN
Tissue specificity: Ubiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus.
genes like me logo Genes that share expression patterns with DCDC2: view

Protein tissue co-expression partners for DCDC2 Gene

Primer Products

In Situ Assay Products

Orthologs for DCDC2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCDC2 35
  • 86.95 (n)
  • 84.89 (a)
DCDC2 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCDC2 35
  • 87.32 (n)
  • 86.34 (a)
DCDC2 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcdc2a 35
  • 82.81 (n)
  • 83.37 (a)
Dcdc2a 16
Dcdc2a 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcdc2 35
  • 83.58 (n)
  • 83.16 (a)
oppossum
(Monodelphis domestica)
Mammalia DCDC2 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC2 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCDC2 36
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCDC2 35
  • 69.16 (n)
  • 63.89 (a)
DCDC2 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC2 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcdc2 35
  • 66.39 (n)
  • 67.04 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC52970 35
zebrafish
(Danio rerio)
Actinopterygii dcdc2b 35
  • 53.71 (n)
  • 47.77 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8501 36
  • 20 (a)
OneToMany
Species with no ortholog for DCDC2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCDC2 Gene

ENSEMBL:
Gene Tree for DCDC2 (if available)
TreeFam:
Gene Tree for DCDC2 (if available)

Paralogs for DCDC2 Gene

Paralogs for DCDC2 Gene

(2) SIMAP similar genes for DCDC2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCDC2: view

Variants for DCDC2 Gene

Sequence variations from dbSNP and Humsavar for DCDC2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs793664 -- 24,370,130(+) TCATA(C/T)GGAAG intron-variant
rs793665 -- 24,363,053(+) CTTCA(C/G)ATGGA intron-variant
rs793666 -- 24,364,694(+) AAAAA(C/T)TGGAA intron-variant
rs793674 -- 24,347,655(-) GAGGA(C/T)ACCAA intron-variant
rs793675 -- 24,350,193(-) GAAAT(G/T)CTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC2 Gene

Variant ID Type Subtype PubMed ID
esv1324202 CNV Insertion 17803354
esv2456318 CNV Insertion 19546169
nsv512869 CNV Insertion 21212237
nsv511339 CNV Loss 21212237
dgv1081e199 CNV Deletion 23128226
nsv511857 CNV Loss 21212237
dgv1003n67 CNV Loss 20364138
esv23337 CNV Loss 19812545
esv2731711 CNV Deletion 23290073
esv9426 CNV Loss 19470904
esv2671001 CNV Deletion 23128226
esv32656 CNV Loss 17666407
esv33852 CNV Loss 17666407
esv33412 CNV Loss 17666407
esv269112 CNV Insertion 20981092

Variation tolerance for DCDC2 Gene

Residual Variation Intolerance Score: 67.82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.01; 84.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCDC2 Gene

HapMap Linkage Disequilibrium report
DCDC2
Human Gene Mutation Database (HGMD)
DCDC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC2 Gene

Disorders for DCDC2 Gene

MalaCards: The human disease database

(12) MalaCards diseases for DCDC2 Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
nephronophthisis 19
  • nphp19
deafness, autosomal recessive 66
  • deafness, autosomal recessive, 66
nonsyndromic deafness
  • nonsyndromic hearing loss
hermansky-pudlak syndrome 5
  • hps 5
dyslexia
- elite association
Search DCDC2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DCDC2_HUMAN
  • Dyslexia 2 (DYX2) [MIM:600202]: A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. {ECO:0000269 PubMed:16278297}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
  • Nephronophthisis 19 (NPHP19) [MIM:616217]: A form of nephronophthisis, an autosomal recessive disorder characterized by chronic tubulointerstitial nephritis resulting in end-stage renal disease. NPHP19 patients also manifest hepatosplenomegaly, hepatic fibrosis, destruction of the bile ducts, focal bile ductal proliferation, ductal plate malformation, and cholestasis. {ECO:0000269 PubMed:25557784}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DCDC2

Genetic Association Database (GAD)
DCDC2
Human Genome Epidemiology (HuGE) Navigator
DCDC2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCDC2
genes like me logo Genes that share disorders with DCDC2: view

No data available for Genatlas for DCDC2 Gene

Publications for DCDC2 Gene

  1. DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling. (PMID: 25557784) Schueler M. … Hildebrandt F. (Am. J. Hum. Genet. 2015) 2 67
  2. Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample. (PMID: 19018237) Ludwig K.U. … Hoffmann P. (Psychiatr. Genet. 2008) 23 67
  3. Breakthroughs in the search for dyslexia candidate genes. (PMID: 16781891) McGrath L.M. … Pennington B.F. (Trends Mol Med 2006) 23 67
  4. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 2 67
  5. A new antigen recognized by cytolytic T lymphocytes on a human kidney tumor results from reverse strand transcription. (PMID: 10601354) Van den Eynde B.J. … Boon T. (J. Exp. Med. 1999) 2 67

Products for DCDC2 Gene

Sources for DCDC2 Gene

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