DCDC1 Gene
protein-coding GIFtS: 40
GCID: GC11M030964
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doublecortin domain containing 1
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Aliases
for DCDC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Doublecortin Domain Containing 11 2 | | Doublecortin Domain-Containing Protein 12 |
Export aliases for DCDC1 gene to outside databasesPrevious GC identifers: GC00U900980 GC11M031248 GC11M031240 |
Summaries
for DCDC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DCDC1:
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellularprotein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubulepolymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. (provided by RefSeq,Sep 2010)
|
Genomic Views
for DCDC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCDC1 gene promoter:
Sox5 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 FOXL1 POU2F1 POU2F1a Pax-4a TGIF
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCDC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCDC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p13 Ensembl cytogenetic band: 11p13 HGNC cytogenetic band: 11p14.1DCDC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M030964: view genomic region
(about GC identifiers)
Start:
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30,964,749 bp from pter |
End:
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31,391,357 bp from pter |
Size:
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426,609 bases |
Orientation:
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minus strand |
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Proteins
for DCDC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCDC1_HUMAN, P59894 (See
protein sequence)Recommended Name: Doublecortin domain-containing protein 1 Size: 354 amino acids; 39859 Da
Secondary accessions: A6PVL6Explore the universe of human proteins at neXtProt for DCDC1: NX_P59894
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P59894
DCDC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_861523.2
ENSEMBL proteins: ENSP00000343496 ENSP00000389792
Human Recombinant Protein Products for DCDC1:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
-- | -- |
DCDC1 for ontologies About GeneDecksing
DCDC1 Antibody Products:
Assay Products for DCDC1: |
Protein
Domains /
Families
for DCDC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCDC1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P59894ProtoNet protein and cluster: P59894 UniProtKB/Swiss-Prot: DCDC1_HUMAN, P59894Similarity: Contains 1 doublecortin domain |
Function
for DCDC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DCDC1 (NM_181807) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCDC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCDC1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCDC1 |
|
Pathways & Interactions
for DCDC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCDC1
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035556 | intracellular signal transduction |
IEA | -- |
DCDC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for DCDC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCDC1
Search CenterWatch for drugs/clinical trials and news about DCDC1
|
Transcripts
for DCDC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCDC1 gene: NM_181807.3 Unigene Cluster for DCDC1: Doublecortin domain containing 1 Hs.592000 [show with all ESTs]Unigene Representative Sequence: NM_1818074 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000342355(uc001msu.2) ENST00000534722 ENST00000534021 ENST00000452803(uc001msv.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCDC1 (NM_181807) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCDC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCDC1 |
Additional cDNA sequence: AY247970.1 3 DOTS entries: DT.40126928 DT.40125715 DT.101955217 24/29 AceView cDNA sequences (see all 29): AA833549 BX097338 AI056882 NM_198462 BX117620 AW340116 AK128035 AA004887 AA005095 BX647348 AA846321 BX116244 AB040926 AI040110 AK126066 BF957112 AI684432 AY247970 NM_181807 AA954541 AI150472 AI243215 AA680369 T55429
GeneLoc Exon Structure
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Expression
for DCDC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCDC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAAGCATT
About this image
See DCDC1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.592000
UniProtKB/Swiss-Prot: DCDC1_HUMAN, P59894Tissue specificity: Highly expressed in testis. Lower levels of expression in lung, kidney, and pancreas. Higherexpression in fetal brain than in adult brain
SABiosciences Custom PCR Arrays for DCDC1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCDC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DCDC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCDC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCDC1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCDC1 |
Orthologs
for DCDC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DCDC1 (if available)
TreeFam Gene Tree for DCDC1 (if available) |
Paralogs
for DCDC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DCDC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCDC1 (30964749 - 31214749 bp, first 250kb of DCDC1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DCDC1
3 CNVs: 4733 9180 34958 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCDC1 |
|
Disorders
/ Diseases
for DCDC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DCDC1 for disorders About GeneDecksing
OMIM gene information: 608062
OMIM disorders: --
2  diseases for DCDC1: About MalaCardsaniridia lissencephaly
1 disease from the University of Copenhagen DISEASES database for DCDC1:Aniridia Export disorders for DCDC1 gene to outside databases
|
Publications
for DCDC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCDC1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DCDC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis. (PubMed id 12820024)1, 2, 3, 9 Zeng L....Mao Y. (2003)
- A 556 kb deletion in the downstream region of the PAX 6 gene causes familial aniridia and other eye anomalies in a Chinese family. (PubMed id 21321669)1 Cheng F....Yuan H. (2011)
- The doublecortin gene family and disorders of neurona l structure. (PubMed id 20236041)1 Dijkmans T.F....Vreugdenhil E. (2010)
- Twenty bone-mineral-density loci identified by large- scale meta-analysis of genome-wide association studies. (PubMed id 19801982)1 Rivadeneira F....Uitterlinden A.G. (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The evolving doublecortin (DCX) superfamily. (PubMed id 16869982)1 Reiner O....Bergmann S. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
|
External Searches for DCDC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCDC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCDC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCDC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCDC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCDC1 gene:
Search GeneIP for patents involving DCDC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCDC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DCDC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCDC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCDC1 | | | OriGene Protein Over-expression Lysate for DCDC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DCDC1 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCDC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | DCDC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCDC1 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DCDC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCDC1 |
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