Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCDC1 Gene

Aliases for DCDC1 Gene

  • Doublecortin Domain Containing 1 2 3 5

External Ids for DCDC1 Gene

Previous GeneCards Identifiers for DCDC1 Gene

  • GC00U900980
  • GC11M031248
  • GC11M031240
  • GC11M030964

Summaries for DCDC1 Gene

Entrez Gene Summary for DCDC1 Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCDC1 Gene

DCDC1 (Doublecortin Domain Containing 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC1 Gene

Genomics for DCDC1 Gene

Regulatory Elements for DCDC1 Gene

Enhancers for DCDC1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DCDC1 on UCSC Golden Path with GeneCards custom track

Promoters for DCDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DCDC1 Gene

Chromosome:
11
Start:
30,830,369 bp from pter
End:
31,369,810 bp from pter
Size:
539,442 bases
Orientation:
Minus strand

Genomic View for DCDC1 Gene

Genes around DCDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC1 Gene

Proteins for DCDC1 Gene

  • Protein details for DCDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59894-DCDC1_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 1
    Protein Accession:
    P59894
    Secondary Accessions:
    • A6PVL6
    • B7WNX6
    • Q6ZU04

    Protein attributes for DCDC1 Gene

    Size:
    354 amino acids
    Molecular mass:
    39859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCDC1 Gene

Post-translational modifications for DCDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC1 Gene

No data available for DME Specific Peptides for DCDC1 Gene

Domains & Families for DCDC1 Gene

Protein Domains for DCDC1 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P59894

UniProtKB/Swiss-Prot:

DCDC1_HUMAN :
  • Contains 1 doublecortin domain.
Domain:
  • Contains 1 doublecortin domain.
genes like me logo Genes that share domains with DCDC1: view

No data available for Gene Families for DCDC1 Gene

Function for DCDC1 Gene

Phenotypes for DCDC1 Gene

genes like me logo Genes that share phenotypes with DCDC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC1 Gene

Localization for DCDC1 Gene

Gene Ontology (GO) - Cellular Components for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with DCDC1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for DCDC1 Gene

Pathways & Interactions for DCDC1 Gene

SuperPathways for DCDC1 Gene

No Data Available

Interacting Proteins for DCDC1 Gene

Gene Ontology (GO) - Biological Process for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC1: view

No data available for Pathways by source and SIGNOR curated interactions for DCDC1 Gene

Drugs & Compounds for DCDC1 Gene

No Compound Related Data Available

Transcripts for DCDC1 Gene

mRNA/cDNA for DCDC1 Gene

Unigene Clusters for DCDC1 Gene

Doublecortin domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2:
SP3:

Relevant External Links for DCDC1 Gene

GeneLoc Exon Structure for
DCDC1
ECgene alternative splicing isoforms for
DCDC1

Expression for DCDC1 Gene

mRNA expression in normal human tissues for DCDC1 Gene

mRNA differential expression in normal tissues according to GTEx for DCDC1 Gene

This gene is overexpressed in Pituitary (x8.3), Testis (x6.8), Brain - Hippocampus (x5.4), and Liver (x5.3).

Protein differential expression in normal tissues from HIPED for DCDC1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCDC1 Gene



Protein tissue co-expression partners for DCDC1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCDC1 Gene:

DCDC1

SOURCE GeneReport for Unigene cluster for DCDC1 Gene:

Hs.592000

mRNA Expression by UniProt/SwissProt for DCDC1 Gene:

P59894-DCDC1_HUMAN
Tissue specificity: Highly expressed in testis. Lower levels of expression in lung, kidney, and pancreas. Higher expression in fetal brain than in adult brain.
genes like me logo Genes that share expression patterns with DCDC1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DCDC1 Gene

Orthologs for DCDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCDC1 34
  • 88.56 (n)
  • 80.67 (a)
DCDC1 35
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCDC1 34
  • 90.75 (n)
  • 85.27 (a)
DCDC1 35
  • 69 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCDC1 34
  • 99.06 (n)
  • 98.31 (a)
DCDC1 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC1 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC1 35
  • 58 (a)
OneToOne
Species where no ortholog for DCDC1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC1 Gene

ENSEMBL:
Gene Tree for DCDC1 (if available)
TreeFam:
Gene Tree for DCDC1 (if available)

Paralogs for DCDC1 Gene

(2) SIMAP similar genes for DCDC1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DCDC1: view

No data available for Paralogs for DCDC1 Gene

Variants for DCDC1 Gene

Sequence variations from dbSNP and Humsavar for DCDC1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2761591 - 31,307,826(-) GACTC(A/C/G)TGCAT reference, missense
rs11031357 - 31,328,261(+) GATCT(C/T)CTGCT reference, missense
rs1023118 -- 31,275,436(+) TAGGT(A/G)TACAC intron-variant
rs1073994 -- 31,367,714(+) tgtaa(A/T)gtatc intron-variant
rs1323737 -- 31,342,064(-) TTGGT(A/G)CTGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC1 Gene

Variant ID Type Subtype PubMed ID
dgv1734n54 CNV loss 21841781
esv2658686 CNV deletion 23128226
esv2751022 CNV loss 17911159
esv3579461 CNV loss 25503493
esv3625826 CNV loss 21293372
nsv1040432 CNV loss 25217958
nsv1042013 CNV loss 25217958
nsv1046329 CNV loss 25217958
nsv1139547 CNV duplication 24896259
nsv467784 CNV loss 19166990
nsv478430 CNV novel sequence insertion 20440878
nsv508621 CNV deletion 20534489
nsv529004 CNV loss 19592680
nsv553949 CNV loss 21841781
nsv553950 CNV loss 21841781
nsv7725 CNV deletion 18451855
nsv832106 CNV gain 17160897
nsv975898 CNV duplication 23825009

Variation tolerance for DCDC1 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.46; 88.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCDC1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCDC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCDC1 Gene

Disorders for DCDC1 Gene

Relevant External Links for DCDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCDC1

No disorders were found for DCDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCDC1 Gene

Publications for DCDC1 Gene

  1. Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis. (PMID: 12820024) Zeng L. … Mao Y. (J. Hum. Genet. 2003) 2 3 4 22 65
  2. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3 65
  3. A 556 kb deletion in the downstream region of the PAX6 gene causes familial aniridia and other eye anomalies in a Chinese family. (PMID: 21321669) Cheng F. … Yuan H. (Mol. Vis. 2011) 3 65
  4. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3 65
  5. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3 65

Products for DCDC1 Gene

Sources for DCDC1 Gene

Content
Loading form....