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Aliases for DCDC1 Gene

Aliases for DCDC1 Gene

  • Doublecortin Domain Containing 1 2 3 5

External Ids for DCDC1 Gene

Previous GeneCards Identifiers for DCDC1 Gene

  • GC00U900980
  • GC11M031248
  • GC11M031240
  • GC11M030964

Summaries for DCDC1 Gene

Entrez Gene Summary for DCDC1 Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCDC1 Gene

DCDC1 (Doublecortin Domain Containing 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC1 Gene

Genomics for DCDC1 Gene

Regulatory Elements for DCDC1 Gene

Enhancers for DCDC1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCDC1 on UCSC Golden Path with GeneCards custom track

Promoters for DCDC1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCDC1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCDC1 Gene

30,830,369 bp from pter
31,369,810 bp from pter
539,442 bases
Minus strand

Genomic View for DCDC1 Gene

Genes around DCDC1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCDC1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC1 Gene

Proteins for DCDC1 Gene

  • Protein details for DCDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Doublecortin domain-containing protein 1
    Protein Accession:
    Secondary Accessions:
    • A6PVL6
    • B7WNX6
    • Q6ZU04

    Protein attributes for DCDC1 Gene

    354 amino acids
    Molecular mass:
    39859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCDC1 Gene


neXtProt entry for DCDC1 Gene

Proteomics data for DCDC1 Gene at MOPED

Post-translational modifications for DCDC1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCDC1 Gene

No data available for DME Specific Peptides for DCDC1 Gene

Domains & Families for DCDC1 Gene

Protein Domains for DCDC1 Gene


Graphical View of Domain Structure for InterPro Entry



  • Contains 1 doublecortin domain.
  • Contains 1 doublecortin domain.
genes like me logo Genes that share domains with DCDC1: view

No data available for Gene Families for DCDC1 Gene

Function for DCDC1 Gene

Phenotypes for DCDC1 Gene

genes like me logo Genes that share phenotypes with DCDC1: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCDC1 Gene

Localization for DCDC1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DCDC1 Gene

Pathways & Interactions for DCDC1 Gene

SuperPathways for DCDC1 Gene

No Data Available

Interacting Proteins for DCDC1 Gene

Gene Ontology (GO) - Biological Process for DCDC1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCDC1 Gene

Drugs & Compounds for DCDC1 Gene

No Compound Related Data Available

Transcripts for DCDC1 Gene

mRNA/cDNA for DCDC1 Gene

Unigene Clusters for DCDC1 Gene

Doublecortin domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -

Relevant External Links for DCDC1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCDC1 Gene

mRNA expression in normal human tissues for DCDC1 Gene

mRNA differential expression in normal tissues according to GTEx for DCDC1 Gene

This gene is overexpressed in Pituitary (x8.3), Testis (x6.8), Brain - Hippocampus (x5.4), and Liver (x5.3).

Protein differential expression in normal tissues from HIPED for DCDC1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCDC1 Gene

SOURCE GeneReport for Unigene cluster for DCDC1 Gene Hs.592000

mRNA Expression by UniProt/SwissProt for DCDC1 Gene

Tissue specificity: Highly expressed in testis. Lower levels of expression in lung, kidney, and pancreas. Higher expression in fetal brain than in adult brain.
genes like me logo Genes that share expression patterns with DCDC1: view

Protein tissue co-expression partners for DCDC1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DCDC1 Gene

Orthologs for DCDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCDC1 35
  • 88.56 (n)
  • 80.67 (a)
DCDC1 36
  • 78 (a)
(Canis familiaris)
Mammalia DCDC1 35
  • 90.75 (n)
  • 85.27 (a)
DCDC1 36
  • 69 (a)
(Pan troglodytes)
Mammalia DCDC1 35
  • 99.06 (n)
  • 98.31 (a)
DCDC1 36
  • 98 (a)
(Ornithorhynchus anatinus)
Mammalia DCDC1 36
  • 62 (a)
(Anolis carolinensis)
Reptilia DCDC1 36
  • 58 (a)
Species with no ortholog for DCDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC1 Gene

Gene Tree for DCDC1 (if available)
Gene Tree for DCDC1 (if available)

Paralogs for DCDC1 Gene

(2) SIMAP similar genes for DCDC1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DCDC1: view

No data available for Paralogs for DCDC1 Gene

Variants for DCDC1 Gene

Sequence variations from dbSNP and Humsavar for DCDC1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2761591 - 31,307,826(-) GACTC(A/C/G)TGCAT reference, missense
rs11031357 - 31,328,261(+) GATCT(C/T)CTGCT reference, missense
rs593837 -- 31,362,686(+) TCATG(A/G)TGCTT intron-variant
rs672396 -- 31,364,618(+) AAAAA(A/G)TATTT intron-variant
rs687276 -- 31,363,659(+) TCATT(A/G)TACTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC1 Gene

Variant ID Type Subtype PubMed ID
nsv529004 CNV Loss 19592680
esv2751022 CNV Loss 17911159
nsv832106 CNV Gain 17160897
nsv897177 CNV Loss 21882294
nsv897178 CNV Loss 21882294
esv2658686 CNV Deletion 23128226
nsv7725 CNV Loss 18451855
nsv508621 CNV Loss 20534489
nsv467784 CNV Loss 19166990

Variation tolerance for DCDC1 Gene

Residual Variation Intolerance Score: 37.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.46; 88.67% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DCDC1 Gene

Disorders for DCDC1 Gene

Relevant External Links for DCDC1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCDC1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCDC1 Gene

Publications for DCDC1 Gene

  1. Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis. (PMID: 12820024) Zeng L. … Mao Y. (J. Hum. Genet. 2003) 2 3 4 23 67
  2. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3
  3. A 556 kb deletion in the downstream region of the PAX6 gene causes familial aniridia and other eye anomalies in a Chinese family. (PMID: 21321669) Cheng F. … Yuan H. (Mol. Vis. 2011) 3
  4. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3
  5. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3

Products for DCDC1 Gene

Sources for DCDC1 Gene