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Aliases for DCDC1 Gene

Aliases for DCDC1 Gene

  • Doublecortin Domain Containing 1 2 3

External Ids for DCDC1 Gene

Summaries for DCDC1 Gene

Entrez Gene Summary for DCDC1 Gene

  • This gene encodes a member of the doublecortin family. The protein encoded by this gene is a hydrophilic, intracellular protein. It contains a single doublecortin domain and is unable to bind microtubules and to regulate microtubule polymerization. This gene is mainly expressed in adult testis. It does not have a mouse homolog. [provided by RefSeq, Sep 2010]

GeneCards Summary for DCDC1 Gene

DCDC1 (Doublecortin Domain Containing 1) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCDC1 Gene

Genomics for DCDC1 Gene

Genomic Location for DCDC1 Gene

Start:
30,830,369 bp from pter
End:
31,369,810 bp from pter
Size:
539,442 bases
Orientation:
Minus strand

Genomic View for DCDC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCDC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCDC1 Gene

Regulatory Elements for DCDC1 Gene

Proteins for DCDC1 Gene

  • Protein details for DCDC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59894-DCDC1_HUMAN
    Recommended name:
    Doublecortin domain-containing protein 1
    Protein Accession:
    P59894
    Secondary Accessions:
    • A6PVL6
    • B7WNX6
    • Q6ZU04

    Protein attributes for DCDC1 Gene

    Size:
    354 amino acids
    Molecular mass:
    39859 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCDC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCDC1 Gene

Proteomics data for DCDC1 Gene at MOPED

Post-translational modifications for DCDC1 Gene

No Post-translational modifications

Other Protein References for DCDC1 Gene

No data available for DME Specific Peptides for DCDC1 Gene

Domains for DCDC1 Gene

Protein Domains for DCDC1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DCDC1_HUMAN
Domain:
  • Contains 1 doublecortin domain.:
    • P59894
genes like me logo Genes that share domains with DCDC1: view

No data available for Gene Families for DCDC1 Gene

Function for DCDC1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DCDC1 Gene

Localization for DCDC1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCDC1 Gene COMPARTMENTS Subcellular localization image for DCDC1 gene
Compartment Confidence
nucleus 3
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for DCDC1 Gene

Pathways for DCDC1 Gene

SuperPathways for DCDC1 Gene

No Data Available

Interacting Proteins for DCDC1 Gene

Gene Ontology (GO) - Biological Process for DCDC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with DCDC1: view

No data available for Pathways by source for DCDC1 Gene

Transcripts for DCDC1 Gene

mRNA/cDNA for DCDC1 Gene

Unigene Clusters for DCDC1 Gene

Doublecortin domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCDC1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2:
SP3:

Relevant External Links for DCDC1 Gene

GeneLoc Exon Structure for
DCDC1
ECgene alternative splicing isoforms for
DCDC1

Expression for DCDC1 Gene

mRNA expression in normal human tissues for DCDC1 Gene

mRNA differential expression in normal tissues according to GTEx for DCDC1 Gene

This gene is overexpressed in Pituitary (8.3), Testis (6.8), Brain - Hippocampus (5.4), and Liver (5.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DCDC1 Gene

SOURCE GeneReport for Unigene cluster for DCDC1 Gene Hs.592000

mRNA Expression by UniProt/SwissProt for DCDC1 Gene

P59894-DCDC1_HUMAN
Tissue specificity: Highly expressed in testis. Lower levels of expression in lung, kidney, and pancreas. Higher expression in fetal brain than in adult brain.
genes like me logo Genes that share expressions with DCDC1: view

Orthologs for DCDC1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCDC1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCDC1 36
  • 99.06 (n)
  • 98.31 (a)
DCDC1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCDC1 36
  • 88.56 (n)
  • 80.67 (a)
DCDC1 37
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCDC1 36
  • 90.75 (n)
  • 85.27 (a)
DCDC1 37
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCDC1 37
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCDC1 37
  • 58 (a)
OneToOne
Species with no ortholog for DCDC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCDC1 Gene

ENSEMBL:
Gene Tree for DCDC1 (if available)
TreeFam:
Gene Tree for DCDC1 (if available)

Paralogs for DCDC1 Gene

Selected SIMAP similar genes for DCDC1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DCDC1: view

No data available for Paralogs for DCDC1 Gene

Variants for DCDC1 Gene

Sequence variations from dbSNP and Humsavar for DCDC1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs494464 -- 31,364,603(+) AAGTG(C/T)GGTGC intron-variant
rs593837 -- 31,362,686(+) TCATG(A/G)TGCTT intron-variant
rs672396 -- 31,364,618(+) AAAAA(A/G)TATTT intron-variant
rs687276 -- 31,363,659(+) TCATT(A/G)TACTC intron-variant
rs768734 -- 31,341,104(-) CCCTA(C/G)TAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCDC1 Gene

Variant ID Type Subtype PubMed ID
nsv529004 CNV Loss 19592680
esv2751022 CNV Loss 17911159
nsv832106 CNV Gain 17160897
nsv897177 CNV Loss 21882294
nsv897178 CNV Loss 21882294
esv2658686 CNV Deletion 23128226
nsv7725 CNV Loss 18451855
nsv508621 CNV Loss 20534489
nsv467784 CNV Loss 19166990

Relevant External Links for DCDC1 Gene

HapMap Linkage Disequilibrium report
DCDC1

Disorders for DCDC1 Gene

(1) University of Copenhagen DISEASES for DCDC1 Gene

genes like me logo Genes that share disorders with DCDC1: view

No data available for UniProtKB/Swiss-Prot for DCDC1 Gene

Publications for DCDC1 Gene

  1. Identification of a novel human doublecortin-domain-containing gene (DCDC1) expressed mainly in testis. (PMID: 12820024) Zeng L. … Mao Y. (J. Hum. Genet. 2003) 2 3 4 23
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. The evolving doublecortin (DCX) superfamily. (PMID: 16869982) Reiner O. … Bergmann S. (BMC Genomics 2006) 3
  4. Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. (PMID: 19801982) Rivadeneira F. … Uitterlinden A.G. (Nat. Genet. 2009) 3
  5. The doublecortin gene family and disorders of neuronal structure. (PMID: 20236041) Dijkmans T.F. … Vreugdenhil E. (Cent. Nerv. Syst. Agents Med. Chem. 2010) 3

Products for DCDC1 Gene

Sources for DCDC1 Gene

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