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DCDC1 Gene

protein-coding   GIFtS: 43

GC11M031240
doublecortin domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Descriptions
doublecortin domain containing 1 2
External Ids
HGNC: 206251
Entrez Gene: 3410192
UniProtKB: P598943
Ensembl: ENSG000001866887
Search outside databases for aliases for DCDC1 gene

Previous GC identifers: GC00U900980 GC11M031248

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DCDC1 gene  

Entrez Gene cytogenetic band: 11p13   Ensembl cytogenetic band:  11p13   HGNC cytogenetic band: 11p14.1

DCDC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M031240:     (about GC identifiers)

Start:
31,240,747 bp from pter
End:
31,347,933 bp from pter
Size:
107,187 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000011.8  NT_009237.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DCDC1_HUMAN, P59894 (See protein sequence)
Recommended Name: Doublecortin domain-containing protein 1  
Size: 354 amino acids; 39859 Da
Secondary accessions: A6PVL6

REFSEQ proteins: NP_861523.2  

ENSEMBL proteins: 
ENSP00000335085 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
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Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for DCDC1: 
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Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for DCDC1

Assays for DCDC1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro domain/family:
 IPR003533 DCX


   GeneDecks  DCDC1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P59894

ProtoNet protein and cluster: P59894

UniProtKB/Swiss-Prot: DCDC1_HUMAN, P59894
Similarity: Contains 1 doublecortin domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (DCDC1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181807

              Applied Biosystems Silencer® siRNAs for DCDC1

              Sigma-Aldrich siRNA for DCDC1  
                     Sigma-Aldrich shRNA for DCDC1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_181807
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_181807
                                 untagged cDNA clone in CMV expression vector: NM_181807 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_181807

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for DCDC1 (ENSP000003350853) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
DCXENSP000003507763STRING (score=.724)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007242 intracellular signaling cascade IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DCDC1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (DCDC1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_181807

              Sigma-Aldrich siRNA for DCDC1  
                     Sigma-Aldrich shRNA for DCDC1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_181807  

REFSEQ mRNAs for DCDC1 gene: 

NM_181807.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_181807  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_181807
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_181807
                                 untagged cDNA clone in CMV expression vector: NM_181807 

Additional cDNA sequence: AY247970.1 

3 DOTS entries:

DT.40126928  DT.40125715  DT.101955217 

24/29 AceView cDNA sequences (see all 29 ):

NM_198462 BX097338 AA833549 BX117620 AI056882 AK126066 AA004887 AA005095 
AA846321 AI040110 AB040926 AW340116 BX116244 BX647348 AK128035 NM_181807 
AI150472 AA954541 AY247970 AI243215 BF957112 AI684432 AA680369 AL713024 

highest scoring ESTs for DCDC1:

AY247970 DB090201 AA846321 AA954541 CD693370 NM_181807 DB301632 AI684432 BX097338 AL713024 

Unigene Cluster for DCDC1:

Doublecortin domain containing 1
Hs.592000  [show with all ESTs]
Unigene Representative Sequence: AY247970


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000354034  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DCDC1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for DCDC1

1 / 2 / 3

2 probe-sets matching DCDC1 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

66533_at2, 3 U95-C 2 0.94 0.50 0.01 0.40 AA846321 0.60 0.83 0.73 1

52942_at2, 3 U95-C 1 0.88 1.00 1.00 1.00 AA954541 0.60 0.83 0.73 1
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TGGAAGCATT

SOURCE GeneReport for Unigene cluster: Hs.592000

UniProtKB/Swiss-Prot: DCDC1_HUMAN, P59894
Tissue specificity: Highly expressed in testis. Lower levels of expression in lung, kidney, and
pancreas. Higher expression in fetal brain than in adult brain

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for DCDC1 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
DCDC11   -- doublecortin domain containing 1 91.04(n)
86.13(a)
483443  XM_540561.2  XP_540561.2 
chimpanzee
(Pan troglodytes)
DCDC11   -- doublecortin domain containing 1 99.06(n)
98.31(a)
737064  XM_001140322.1  XP_001140322.1 
cow
(Bos taurus)
DCDC11   -- doublecortin domain containing 1 88.56(n)
80.67(a)
616832  NM_001076434.1  NP_001069902.1 
About this table        Species with no ortholog for DCDC1

ENSEMBL Gene Tree for DCDC1
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --
(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/390 NCBI SNPs in DCDC1 are shown (see all 390 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 130)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs27615911,2
A,C,F,H,O31285949(-) GACTCG/ATGCAT 1 M/V mis1 ese311Minor allele frequency- A:0.10EU EA WA NA 980
rs110313571,2
C,F,H31306384(+) GATCTT/CCTGCT 1 G/E mis1 ese38Minor allele frequency- C:0.26EU EA WA 838
--
rs71172861,2
A,C31240386(+) ccttgA/Tctcag 1 -- ng510--------
rs26168151,2
A,C,F,H31283892(-) CTGGAA/GGAGTG 1 E/E syn1 ese38Minor allele frequency- G:0.39EA NA EU WA 632
rs169220661,2
F,H31284412(+) TTGTAA/CGCTGT 1 A/A syn1 ese37Minor allele frequency- C:0.03NA EU EA WA 560
rs13237381,2
A,C,F,H,O31301474(-) CACGAG/ATATGA 1 -- int15Minor allele frequency- A:0.42MN EU EA WA 594
rs15357411,2
A,C,F,H,O31331648(-) CACATG/ATTTAG 1 -- int111Minor allele frequency- A:0.45NA EA MN EU WA 992
rs27615931,2
A,C,F,H,O31283328(-) TTTTTA/CAGATA 1 -- int17Minor allele frequency- C:0.40EU EA WA NA 558
rs26168211,2
A,C,F,H,O31282996(-) TTGGTA/GTCTAG 1 -- int111Minor allele frequency- G:0.29EU EA WA NA 978
--
rs15471311,2
A,C,F,H,O31343175(-) TACTAT/CGCCAG 1 -- int18Minor allele frequency- C:0.31MN NA EU EA WA 744
About this table

HapMap Linkage Disequilibrium images for DCDC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 608062

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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2 PubMed articles for DCDC1 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 341019 HGNC: 20625 AceView: DCDC1 Ensembl:ENSG00000186688 euGenes: HUgn341019
ECgene: DCDC1 H-InvDB: DCDC1
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for DCDC1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Predesigned and custom siRNAs for DCDC1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for DCDC1 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for DCDC1

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