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Aliases for DCD Gene

Aliases for DCD Gene

  • Dermcidin 2 3 5
  • Preproteolysin 2 3 4
  • Diffusible Survival/Evasion Peptide 2 3
  • Proteolysis Inducing Factor 2 3
  • Survival Promoting Peptide 2 3
  • AIDD 3 4
  • DSEP 3 4
  • EC 3.4.-.- 4
  • DCD-1 3
  • HCAP 3
  • PIF 3

External Ids for DCD Gene

Previous GeneCards Identifiers for DCD Gene

  • GC12P049932
  • GC12M055152
  • GC12M054755
  • GC12M053324
  • GC12M055038
  • GC12M052076

Summaries for DCD Gene

Entrez Gene Summary for DCD Gene

  • This antimicrobial gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GeneCards Summary for DCD Gene

DCD (Dermcidin) is a Protein Coding gene. Diseases associated with DCD include skin conditions and angiomyoma. GO annotations related to this gene include poly(A) RNA binding and peptidase activity.

UniProtKB/Swiss-Prot for DCD Gene

  • DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.

  • Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

Gene Wiki entry for DCD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCD Gene

Genomics for DCD Gene

Regulatory Elements for DCD Gene

Genomic Location for DCD Gene

Chromosome:
12
Start:
54,644,591 bp from pter
End:
54,648,493 bp from pter
Size:
3,903 bases
Orientation:
Minus strand

Genomic View for DCD Gene

Genes around DCD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCD Gene

Proteins for DCD Gene

  • Protein details for DCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P81605-DCD_HUMAN
    Recommended name:
    Dermcidin
    Protein Accession:
    P81605
    Secondary Accessions:
    • A5JHP2
    • A5JHP3
    • P58461
    • Q53YJ2

    Protein attributes for DCD Gene

    Size:
    110 amino acids
    Molecular mass:
    11284 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for DCD Gene

    Alternative splice isoforms for DCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCD Gene

Proteomics data for DCD Gene at MOPED

Post-translational modifications for DCD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCD Gene

Antibody Products

No data available for DME Specific Peptides for DCD Gene

Domains & Families for DCD Gene

Protein Domains for DCD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCD: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DCD Gene

Function for DCD Gene

Molecular function for DCD Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Arg- -Xaa, Lys- -Xaa.
UniProtKB/Swiss-Prot Function:
DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.
UniProtKB/Swiss-Prot Function:
Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.

Enzyme Numbers (IUBMB) for DCD Gene

Gene Ontology (GO) - Molecular Function for DCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DCD: view
genes like me logo Genes that share phenotypes with DCD: view

Animal Model Products

miRNA for DCD Gene

miRTarBase miRNAs that target DCD

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCD Gene

Localization for DCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCD Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCD Gene COMPARTMENTS Subcellular localization image for DCD gene
Compartment Confidence
extracellular 5
cytoskeleton 1
cytosol 1
lysosome 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,IDA 9736629
genes like me logo Genes that share ontologies with DCD: view

Pathways & Interactions for DCD Gene

SuperPathways for DCD Gene

No Data Available

Gene Ontology (GO) - Biological Process for DCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042742 defense response to bacterium IEA --
genes like me logo Genes that share ontologies with DCD: view

No data available for Pathways by source and SIGNOR curated interactions for DCD Gene

Drugs & Compounds for DCD Gene

(4) Drugs for DCD Gene - From: ClinicalTrials and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Daclizumab Approved, Investigational Pharma 96,129
Immunologic Factors Pharma 18483
Immunosuppressive Agents Pharma 10422
Manganese Pharma 32
genes like me logo Genes that share compounds with DCD: view

Transcripts for DCD Gene

mRNA/cDNA for DCD Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCD Gene

Dermcidin:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCD Gene

No ASD Table

Relevant External Links for DCD Gene

GeneLoc Exon Structure for
DCD
ECgene alternative splicing isoforms for
DCD

Expression for DCD Gene

mRNA expression in normal human tissues for DCD Gene

mRNA differential expression in normal tissues according to GTEx for DCD Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x29.6) and Skin - Not Sun Exposed (Suprapubic) (x21.8).

Protein differential expression in normal tissues from HIPED for DCD Gene

This gene is overexpressed in Brain (19.2), Pancreatic juice (12.4), and Serum (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCD Gene



SOURCE GeneReport for Unigene cluster for DCD Gene Hs.350570

mRNA Expression by UniProt/SwissProt for DCD Gene

P81605-DCD_HUMAN
Tissue specificity: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat at a concentration of 1-10 micrograms/ml.
genes like me logo Genes that share expression patterns with DCD: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for DCD Gene

Orthologs for DCD Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCD 35
  • 99.7 (n)
  • 100 (a)
DCD 36
  • 83 (a)
OneToOne
Species with no ortholog for DCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCD Gene

ENSEMBL:
Gene Tree for DCD (if available)
TreeFam:
Gene Tree for DCD (if available)

Paralogs for DCD Gene

No data available for Paralogs for DCD Gene

Variants for DCD Gene

Sequence variations from dbSNP and Humsavar for DCD Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs903768 -- 54,647,295(-) TTGTG(A/T)AGCAG intron-variant
rs868690 -- 54,647,491(-) TAGAG(C/T)AGGTG intron-variant
rs1495928 -- 54,646,721(-) TCAGG(A/G)TATCC intron-variant
rs2222876 -- 54,645,737(+) AATAA(A/C/T)AGCTA intron-variant
rs2029851 -- 54,647,653(-) acact(A/G)tctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCD Gene

Variant ID Type Subtype PubMed ID
nsv832421 CNV Gain 17160897

Variation tolerance for DCD Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.93; 35.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCD Gene

HapMap Linkage Disequilibrium report
DCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCD Gene

Disorders for DCD Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCD Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
skin conditions
  • dermatologic disorders
angiomyoma
  • vascular leiomyoma
- elite association - COSMIC cancer census association via MalaCards
Search DCD in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCD

Genetic Association Database (GAD)
DCD
Human Genome Epidemiology (HuGE) Navigator
DCD
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCD
genes like me logo Genes that share disorders with DCD: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCD Gene

Publications for DCD Gene

  1. Dermcidin: a novel human antibiotic peptide secreted by sweat glands. (PMID: 11694882) Schittek B. … Garbe C. (Nat. Immunol. 2001) 2 3 4 23 67
  2. Analysis of the solution structure of the human antibiotic peptide dermcidin and its interaction with phospholipid vesicles. (PMID: 20510021) Jung H.H. … Kim J.I. (BMB Rep. 2010) 3 23
  3. The dermcidin gene in cancer: role in cachexia, carcinogenesis and tumour cell survival. (PMID: 18403914) Stewart G.D. … Baracos V.E. (Curr Opin Clin Nutr Metab Care 2008) 3 23
  4. Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines. (PMID: 18594538) Stewart G.D. … Ross J.A. (Br. J. Cancer 2008) 3 23
  5. Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. (PMID: 17448443) Lee Motoyama J.P. … Suzuki K. (Biochem. Biophys. Res. Commun. 2007) 3 23

Products for DCD Gene

Sources for DCD Gene

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