DCD Gene
protein-coding GIFtS: 47
GCID: GC12M055038
|
|
dermcidin
| |
Aliases
for DCD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dermcidin1 | | Diffusible Survival/Evasion Peptide2 | | AIDD1 2 3 | | Preproteolysin3 | | DSEP1 2 3 | | Proteolysis Inducing Factor2 | | DCD-11 2 | | Survival Promoting Peptide2 | | HCAP1 2 | | EC 3.4.-.-3 | | PIF1 2 | | Preproteolysin3 |
Export aliases for DCD gene to outside databasesPrevious GC identifers: GC12P049932 GC12M055152 GC12M054755 GC12M053324 GC12M052076 |
Summaries
for DCD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DCD:
This gene encodes a secreted protein that is subsequently processed into mature peptides of distinct biologicalactivities. The C-terminal peptide is constitutively expressed in sweat and has antibacterial and antifungalactivities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survivalunder conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated withcachexia (muscle wasting) in cancer patients. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DCD_HUMAN, P81605Function: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first fewhours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pHand salt concentration resemble the conditions in sweat. Also exhibits proteolytic activityFunction: Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG
Gene Wiki entry for DCD (Dermcidin)
|
Genomic Views
for DCD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCD gene promoter:
TBP STAT5B HFH-3 AML1a LCR-F1 HNF-3beta Evi-1 FOXI1 POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.1 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.1DCD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M055038: view genomic region
(about GC identifiers)
Start:
|
55,038,375 bp from pter |
End:
|
55,042,277 bp from pter |
Size:
|
3,903 bases |
Orientation:
|
minus strand |
|
Proteins
for DCD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCD_HUMAN, P81605 (See
protein sequence)Recommended Name: Dermcidin precursor Size: 110 amino acids; 11284 Da
Cofactor: Manganese. Required for survival-promoting peptide
Subcellular location: Secreted
Mass spectrometry: Mass=4702.57; Method=Electrospray; Range=63-109; Source=PubMed:11694882;
2 PDB 3D structures from  and Proteopedia  for DCD:2KSG (3D)
2YMK (3D)
Secondary accessions: A5JHP2 A5JHP3 P58461 Q53YJ2Alternative splicing: 3 isoforms: P81605-1 P81605-2 P81605-3 Explore the universe of human proteins at neXtProt for DCD: NX_P81605
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P81605
DCD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_444513.1
ENSEMBL proteins: ENSP00000293371 ENSP00000450415 ENSP00000406773
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
DCD for ontologies About GeneDecksing
DCD Antibody Products:
Assay Products for DCD: |
Protein
Domains /
Families
for DCD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: P81605 |
Function
for DCD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DCD_HUMAN, P81605Function: DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first fewhours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pHand salt concentration resemble the conditions in sweat. Also exhibits proteolytic activityFunction: Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgGCatalytic activity: Preferential cleavage: Arg- -Xaa, Lys- -XaaEnzyme Number (IUBMB): EC 3.4.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCD
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DCD (NM_005018) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCD |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008233 | peptidase activity |
IEA | -- |
DCD for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for DCD:
|
Pathways & Interactions
for DCD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DCD
STRING Interaction
Network Preview (showing 5 interactants - click image to see 23)
5/54 Interacting proteins for DCD (P816053 ENSP000002933714) via UniProtKB, MINT, STRING, and/or I2D (see all 54)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- | | GO:0031640 | killing of cells of other organism |
IEA | -- | | GO:0042742 | defense response to bacterium |
IEA | -- | | GO:0050832 | defense response to fungus |
IEA | -- |
DCD for ontologies About GeneDecksing
|
Drugs & Compounds
for DCD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCD
1 HMDB Compound for DCD About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| Manganese | manganese | 7439-96-5 | -- |
Search CenterWatch for drugs/clinical trials and news about DCD
|
Transcripts
for DCD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCD gene: NM_053283.2 Unigene Cluster for DCD: Dermcidin Hs.350570 [show with all ESTs]Unigene Representative Sequence: CB9992283 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000293371(uc001sgj.3) ENST00000546807(uc009znu.3) ENST00000456047(uc009znt.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCD
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCD
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCD (NM_005018) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCD |
Additional cDNA sequence: AF144011.1 AY590150.1 BC062682.1 BC069108.1 EF503687.1 EF503688.1 EF503689.1 1 DOTS entry: DT.99945647 8 AceView cDNA sequences: BC069108 NM_053283 CD103709 AF144011 BC062682 AL598959 AY590150 CD000439
GeneLoc Exon Structure
|
Expression
for DCD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACGTTAAAGA
About this image
See DCD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCD
SOURCE GeneReport for Unigene cluster: Hs.350570
UniProtKB/Swiss-Prot: DCD_HUMAN, P81605Tissue specificity: Specifically and constitutively expressed in eccrine sweat gland cells. Secreted into the sweat ata concentration of 1-10 micrograms/ml
SABiosciences Custom PCR Arrays for DCD
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DCD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCD |
Orthologs
for DCD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DCD (if available)
TreeFam Gene Tree for DCD (if available) |
Paralogs
for DCD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DCD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCD (55038375 - 55042277 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DCD: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCD |
|
Disorders
/ Diseases
for DCD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DCD for disorders About GeneDecksing
OMIM gene information: 606634
OMIM disorders: --
20/24  diseases for DCD (see all 24): About MalaCardsspinal stenosis clear cell hidradenoma root caries angiomyoma
skin conditions myocardial infarction hidrocystoma acute myocardial infarction
hidradenoma hidradenitis atopic dermatitis muscular atrophy
skin disease squamous cell carcinoma dermatitis vaginitis
breast cancer lung cancer prostatitis prostate cancer
2 diseases from the University of Copenhagen DISEASES database for DCD:Spinal stenosis Muscular atrophy 4 Novoseek disease relationships for DCD gene About this table
Human Genome Epidemiology (HuGE) Navigator: DCD (8 documents)
Export disorders for DCD gene to outside databases
|
Publications
for DCD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCD gene, integrated from 9 sources (see all 81):
(articles sorted by number of sources associating them with DCD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Dermcidin: a novel human antibiotic peptide secreted by sweat glands. (PubMed id 11694882)1, 2, 3, 9 Schittek B.... Garbe C. (2001)
- Analysis of the solution structure of the human antib iotic peptide dermcidin and its interaction with phospholipid vesicles. (PubMed id 20510021)1, 2, 9 Jung H.H....Kim J.I. (2010)
- Identification of dermcidin in human gestational tissue and characterization of its proteolytic activity. (PubMed id 17448443)1, 2, 9 Lee Motoyama J.P....Suzuki K. (2007)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a survival-promoting peptide in medium conditioned by oxidatively stressed cell lines of nervous system origin. (PubMed id 9736629)1, 2 Cunningham T.J.... Wang Y. (1998)
- Variation in dermcidin expression in a range of primary human tumours and in hypoxic/oxidatively stressed human cell lines. (PubMed id 18594538)1, 9 Stewart G.D....Ross J.A. (2008)
- The cachectic mediator proteolysis inducing factor activates NF-kappaB and STAT3 in human Kupffer cells and monocytes. (PubMed id 16142329)1, 9 Watchorn T.M....Ross J.A. (2005)
- Dermcidin expression in hepatic cells improves survival without N-glycosylation, but requires asparagine residues. (PubMed id 16685272)1, 9 Lowrie A.G....Ross J.A. (2006)
- The dermcidin gene in cancer: role in cachexia, carcinogenesis and tumour cell survival. (PubMed id 18403914)1, 9 Stewart G.D....Baracos V.E. (2008)
|
External Searches for DCD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCD | Pharmacogenomics, SNPs, Pathways | | Protein Spotlight | http://web.expasy.org/spotlight/back_issues/sptlt018.shtml |
|
| | |
About This Section
| Patent Information for DCD gene:
Search GeneIP for patents involving DCD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DCD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCD | | | OriGene Protein Over-expression Lysate for DCD | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DCD | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DCD | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DCD | | OriGene Custom Protein Services for DCD | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCD |
| |
 |  |  |  | |
| | | | Search Tocris compounds for DCD |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DCD Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for DCD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCD |
|
|
|
|
