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Aliases for DCC Gene

Aliases for DCC Gene

  • DCC Netrin 1 Receptor 2 3
  • Immunoglobulin Superfamily DCC Subclass Member 1 3 4
  • Deleted In Colorectal Carcinoma 2 3
  • Colorectal Cancer Suppressor 3 4
  • Tumor Suppressor Protein DCC 3 4
  • IGDCC1 3 4
  • MRMV1 3 6
  • Immunoglobulin Superfamily, DCC Subclass, Member 1 3
  • Deleted In Colorectal Cancer Protein 3
  • Colorectal Tumor Suppressor 3
  • Immunoglobulin Superfamily 2
  • Netrin Receptor DCC 3
  • DCC Subclass 2
  • Member 1 2
  • NTN1R1 3
  • CRC18 3
  • CRCR1 3

External Ids for DCC Gene

Summaries for DCC Gene

Entrez Gene Summary for DCC Gene

  • This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

GeneCards Summary for DCC Gene

DCC (DCC Netrin 1 Receptor) is a Protein Coding gene. Diseases associated with DCC include mirror movements 1 and colorectal cancer. Among its related pathways are Pathways in cancer and L1CAM interactions. GO annotations related to this gene include identical protein binding and transmembrane signaling receptor activity. An important paralog of this gene is PRTG.

UniProtKB/Swiss-Prot for DCC Gene

  • Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Gene Wiki entry for DCC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCC Gene

Genomics for DCC Gene

Genomic Location for DCC Gene

Start:
52,340,172 bp from pter
End:
53,535,903 bp from pter
Size:
1,195,732 bases
Orientation:
Plus strand

Genomic View for DCC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCC Gene

Regulatory Elements for DCC Gene

Proteins for DCC Gene

  • Protein details for DCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43146-DCC_HUMAN
    Recommended name:
    Netrin receptor DCC
    Protein Accession:
    P43146
    Secondary Accessions:

    Protein attributes for DCC Gene

    Size:
    1447 amino acids
    Molecular mass:
    158457 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with DSCAM. Interacts with PTK2/FAK1 and MAPK1. Interacts with NTN1 (By similarity). Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity).
    Miscellaneous:
    • Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and hematogenous metastatic tumor dissemination
    SequenceCaution:
    • Sequence=AAA52175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAA52177.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA52179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA52180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCC Gene

neXtProt entry for DCC Gene

Proteomics data for DCC Gene at MOPED

Post-translational modifications for DCC Gene

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn94, Asn299, Asn318, Asn478, Asn628, and Asn702

Other Protein References for DCC Gene

No data available for DME Specific Peptides for DCC Gene

Domains for DCC Gene

Gene Families for DCC Gene

HGNC:
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • FN3 :Fibronectin type III domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

UniProtKB/Swiss-Prot:

DCC_HUMAN
Domain:
  • Contains 6 fibronectin type-III domains.:
    • P43146
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.:
    • P43146
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.:
    • P43146
genes like me logo Genes that share domains with DCC: view

Function for DCC Gene

Molecular function for DCC Gene

GENATLAS Biochemistry: netrin-1 receptor,expressed on spinal commissural axons and processing netrin-1 binding activity,inducing attraction in axon guidance through its cytoplasmic tail,inducing apoptosis in the absence of its ligand,homolog of C elegans UNC-40
UniProtKB/Swiss-Prot Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Gene Ontology (GO) - Molecular Function for DCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IEA --
GO:0004888 transmembrane signaling receptor activity TAS 8861902
GO:0005042 netrin receptor activity IEA --
GO:0005515 protein binding IPI 11527412
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with DCC: view
genes like me logo Genes that share phenotypes with DCC: view

Animal Models for DCC Gene

MGI Knock Outs for DCC:

miRNA for DCC Gene

miRTarBase miRNAs that target DCC

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DCC Gene

Localization for DCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCC Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCC Gene COMPARTMENTS Subcellular localization image for DCC gene
Compartment Confidence
cytosol 4
plasma membrane 4
extracellular 1
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
GO:0030424 axon IEA --
GO:0032584 growth cone membrane IEA --
genes like me logo Genes that share ontologies with DCC: view

Pathways for DCC Gene

genes like me logo Genes that share pathways with DCC: view

Gene Ontology (GO) - Biological Process for DCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0001975 response to amphetamine IEA --
GO:0006915 apoptotic process TAS --
GO:0007409 axonogenesis TAS 8861902
GO:0007411 axon guidance TAS --
genes like me logo Genes that share ontologies with DCC: view

Transcripts for DCC Gene

Unigene Clusters for DCC Gene

Deleted in colorectal carcinoma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCC Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:

Relevant External Links for DCC Gene

GeneLoc Exon Structure for
DCC
ECgene alternative splicing isoforms for
DCC

Expression for DCC Gene

mRNA expression in normal human tissues for DCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCC Gene

This gene is overexpressed in Testis (18.0) and Brain - Nucleus accumbens (basal ganglia) (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DCC Gene

SOURCE GeneReport for Unigene cluster for DCC Gene Hs.162025

mRNA Expression by UniProt/SwissProt for DCC Gene

P43146-DCC_HUMAN
Tissue specificity: Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
genes like me logo Genes that share expressions with DCC: view

Orthologs for DCC Gene

This gene was present in the common ancestor of animals.

Orthologs for DCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCC 36
  • 99.59 (n)
  • 99.86 (a)
DCC 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCC 36
  • 90.92 (n)
  • 96.68 (a)
dog
(Canis familiaris)
Mammalia DCC 36
  • 93.01 (n)
  • 97.53 (a)
DCC 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcc 36
  • 89.68 (n)
  • 96.48 (a)
Dcc 16
Dcc 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCC 37
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 88 (a)
OneToMany
-- 37
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dcc 36
  • 89.53 (n)
  • 96.54 (a)
lizard
(Anolis carolinensis)
Reptilia DCC 37
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dcca-A 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dcc 36
  • 75.71 (n)
  • 82.63 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01100973.1 37
  • 78 (a)
OneToMany
dcc 36
  • 66.24 (n)
  • 73.13 (a)
DCC (2 of 2) 37
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta fra 37
  • 30 (a)
OneToMany
fra 38
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-40 36
  • 46.82 (n)
  • 36.34 (a)
unc-40 37
  • 30 (a)
OneToMany
unc-40 38
  • 33 (a)
Species with no ortholog for DCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCC Gene

ENSEMBL:
Gene Tree for DCC (if available)
TreeFam:
Gene Tree for DCC (if available)

Paralogs for DCC Gene

genes like me logo Genes that share paralogs with DCC: view

Variants for DCC Gene

Sequence variations from dbSNP and Humsavar for DCC Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs714 -- 52,992,904(+) AACCC(A/G)GGAGG intron-variant
rs2256 -- 52,348,434(-) AGAGG(A/C)CTTTC intron-variant
rs16920 -- 52,680,797(-) AGAGA(C/T)TTTTT intron-variant
rs168332 -- 52,456,421(+) AGCAG(A/C)CCCTT intron-variant
rs186984 -- 52,448,691(+) TGGTA(A/G)CAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCC Gene

Variant ID Type Subtype PubMed ID
esv275550 CNV Loss 21479260
esv22158 CNV Loss 19812545
esv1534314 CNV Insertion 17803354
nsv833657 CNV Loss 17160897
nsv2308 CNV Insertion 18451855
esv272016 CNV Insertion 20981092
nsv521063 CNV Loss 19592680
esv2672905 CNV Deletion 23128226
esv267489 CNV Insertion 20981092
nsv515816 CNV Gain 19592680
nsv458076 CNV Gain 19166990
esv2717105 CNV Deletion 23290073
nsv909650 CNV Loss 21882294
esv270128 CNV Insertion 20981092
esv273444 CNV Insertion 20981092
esv2657510 CNV Deletion 23128226
nsv458079 CNV Loss 19166990
nsv516994 CNV Loss 19592680
nsv521932 CNV Loss 19592680
esv2717107 CNV Deletion 23290073
esv2938 CNV Deletion 18987735
esv2717108 CNV Deletion 23290073
esv273869 CNV Insertion 20981092
esv269222 CNV Insertion 20981092
esv2717109 CNV Deletion 23290073
esv2717110 CNV Deletion 23290073
esv2592738 CNV Deletion 19546169
esv2108318 CNV Deletion 18987734
esv23617 CNV Loss 19812545
esv1007284 CNV Loss 20482838
nsv828236 CNV Loss 20364138
esv2717111 CNV Deletion 23290073
esv6032 CNV Loss 19470904
esv2675658 CNV Deletion 23128226
nsv131400 CNV Loss 16902084
esv2518546 CNV Deletion 19546169
nsv2309 CNV Insertion 18451855
esv2251611 CNV Deletion 18987734
esv2717112 CNV Deletion 23290073
esv4836 CNV Deletion 18987735
esv9355 CNV Loss 19470904
nsv130811 CNV Loss 16902084
nsv458080 CNV Loss 19166990
nsv909651 CNV Gain 21882294
esv275215 CNV Loss 21479260
esv2666866 CNV Deletion 23128226
esv1388943 CNV Deletion 17803354
nsv528217 CNV Loss 19592680
esv2717113 CNV Deletion 23290073
esv2252212 CNV Deletion 18987734
esv2717114 CNV Deletion 23290073
esv1146191 CNV Insertion 17803354
esv2717115 CNV Deletion 23290073
nsv909652 CNV Gain 21882294
esv2653679 CNV Deletion 19546169
nsv828237 CNV Gain 20364138
nsv828238 CNV Loss 20364138
esv1010861 CNV Loss 20482838
nsv507872 CNV Insertion 20534489
esv2496857 CNV Deletion 19546169
esv2111490 CNV Deletion 18987734
esv4954 CNV Deletion 18987735
esv7831 CNV Loss 19470904
esv995021 CNV Deletion 20482838
esv1682692 CNV Deletion 17803354
esv2717116 CNV Deletion 23290073
esv2717118 CNV Deletion 23290073
nsv507873 CNV Insertion 20534489
esv2675439 CNV Deletion 23128226
nsv510457 CNV Loss 20534489
esv268292 CNV Insertion 20981092
esv274482 CNV Insertion 20981092
esv1008613 CNV Insertion 20482838
nsv510741 CNV Loss 20534489
nsv2311 CNV Insertion 18451855

Relevant External Links for DCC Gene

HapMap Linkage Disequilibrium report
DCC
Human Gene Mutation Database (HGMD)
DCC

Disorders for DCC Gene

(3) OMIM Diseases for DCC Gene (120470)

UniProtKB/Swiss-Prot

DCC_HUMAN
  • Mirror movements 1 (MRMV1) [MIM:157600]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. {ECO:0000269 PubMed:20431009}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for DCC Gene

Genatlas disease for DCC Gene

colorectal carcinoma,deleted in (see TSG18A) in endometrial carcinoma with lymph node metastasis,and in pancreatic carcinomas

Relevant External Links for DCC

Genetic Association Database (GAD)
DCC
Human Genome Epidemiology (HuGE) Navigator
DCC
Tumor Gene Database (TGDB):
DCC
genes like me logo Genes that share disorders with DCC: view

Publications for DCC Gene

  1. Identification of a chromosome 18q gene that is altered in colorectal cancers. (PMID: 2294591) Fearon E.R. … Vogelstein B. (Science 1990) 2 3 4
  2. The DCC gene product in cellular differentiation and colorectal tumorigenesis. (PMID: 7926722) Hedrick L. … Vogelstein B. (Genes Dev. 1994) 3 4
  3. The deleted in colorectal carcinoma (DCC) gene 201 R --> G polymorphism: no evidence for genetic association with autoimmune disease. (PMID: 14571268) Hall R.J. … Merriman T.R. (Eur. J. Hum. Genet. 2003) 3 49
  4. No association between the Arg201Gly polymorphism of the DCC gene and colorectal cancer. (PMID: 15646429) de Jong M.M. … Kleibeuker J.H. (Dig Liver Dis 2004) 3 49
  5. Deleted in colorectal cancer (DCC) encodes a netrin receptor. (PMID: 8861902) Keino-Masu K. … Tessier-Lavigne M. (Cell 1996) 3 4

Products for DCC Gene

  • Addgene plasmids for DCC

Sources for DCC Gene

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