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DCC Gene

protein-coding   GIFtS: 69
GCID: GC18P049802

Deleted In Colorectal Carcinoma

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deleted In Colorectal Carcinoma1 2     Member 11
Colorectal Cancer Suppressor2 3     CRC182
Immunoglobulin Superfamily DCC Subclass Member 12 3     CRCR12
Tumor Suppressor Protein DCC2 3     Colorectal Tumor Suppressor2
IGDCC12 3     Deleted In Colorectal Cancer Protein2
MRMV12 5     Immunoglobulin Superfamily, DCC Subclass, Member 12
DCC Subclass1     Netrin Receptor DCC2
Immunoglobulin Superfamily1     

External Ids:    HGNC: 27011   Entrez Gene: 16302   Ensembl: ENSG000001873237   OMIM: 1204705   UniProtKB: P431463   

Export aliases for DCC gene to outside databases

Previous GC identifers: GC18P050053 GC18P048119 GC18P048121 GC18P046722


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCC Gene:
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of
cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand.
The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2)
to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence
of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal
cancer and esophageal carcinoma. (provided by RefSeq, Oct 2009)

GeneCards Summary for DCC Gene:
DCC (deleted in colorectal carcinoma) is a protein-coding gene. Diseases associated with DCC include mirror movements 1, and esophageal cancer, somatic. GO annotations related to this gene include transmembrane signaling receptor activity and identical protein binding. An important paralog of this gene is CHL1.

UniProtKB/Swiss-Prot: DCC_HUMAN, P43146
Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the
developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon
repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin
ligand. Implicated as a tumor suppressor gene

Gene Wiki entry for DCC (Deleted in Colorectal Cancer) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NT_010966.15  NC_018929.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DCC gene promoter:
         ISGF-3   RP58   p53   Arnt   Evi-1   C/EBPalpha   HEN1   Nkx6-1   Sox9   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DCC promoter sequence
   Search Chromatin IP Primers for DCC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18q21.3   Ensembl cytogenetic band:  18q21.2   HGNC cytogenetic band: 18q21.1

DCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCC gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P049802:  view genomic region     (about GC identifiers)

Start:
49,866,542 bp from pter      End:
51,062,273 bp from pter
Size:
1,195,732 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DCC_HUMAN, P43146 (See protein sequence)
Recommended Name: Netrin receptor DCC precursor  
Size: 1447 amino acids; 158457 Da
Subunit: Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with DSCAM.
Interacts with PTK2/FAK1 and MAPK1. Interacts with NTN1 (By similarity). Interacts with MYO10. Interacts with
CBLN4; this interaction can be competed by NTN1 (By similarity)
Miscellaneous: Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and
hematogenous metastatic tumor dissemination
Sequence caution: Sequence=AAA52175.1; Type=Erroneous gene model prediction; Sequence=AAA52177.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=AAA52179.1; Type=Erroneous initiation;
Note=Translation N-terminally extended; Sequence=AAA52180.1; Type=Erroneous initiation; Note=Translation
N-terminally extended;
Selected PDB 3D structures from and Proteopedia for DCC (see all 7):
2ED7 (3D)        2ED8 (3D)        2ED9 (3D)        2EDB (3D)        2EDD (3D)        2EDE (3D)    

Explore the universe of human proteins at neXtProt for DCC: NX_P43146

Explore proteomics data for DCC at MOPED

Post-translational modifications: 

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation (Probable)1
  • Glycosylation2 at Asn94, Asn299, Asn318, Asn478, Asn628, Asn702
  • Modification sites at PhosphoSitePlus

  • See DCC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005206.2  
    ENSEMBL proteins: 
     ENSP00000389140   ENSP00000463699   ENSP00000463131   ENSP00000304146   ENSP00000464277  
     ENSP00000463463   ENSP00000464582   ENSP00000463766   ENSP00000464292   ENSP00000397322  
    Reactome Protein details: P43146

    DCC Human Recombinant Protein Products:

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    Novus Biologicals DCC Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCC

    DCC Antibody Products:

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    Novus Biologicals DCC Antibodies
    Abcam antibodies for DCC
    Cloud-Clone Corp. Antibodies for DCC
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    LSBio Antibodies in human, mouse, rat for DCC

    DCC Assay Products:

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    GenScript Custom Assay Services for DCC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCC
    Cloud-Clone Corp. CLIAs for DCC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    Selected InterPro protein domains (see all 7):
     IPR003598 Ig_sub2
     IPR010560 Neogenin_C
     IPR003961 Fibronectin_type3
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry P43146

    ProtoNet protein and cluster: P43146

    3 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB003962 Fibronectin type III repeat signature
    IPB010560 Neogenin


    UniProtKB/Swiss-Prot: DCC_HUMAN, P43146
    Similarity: Belongs to the immunoglobulin superfamily. DCC family
    Similarity: Contains 6 fibronectin type-III domains
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    DCC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCC_HUMAN, P43146
    Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the
    developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon
    repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin
    ligand. Implicated as a tumor suppressor gene

         Genatlas biochemistry entry for DCC:
    netrin-1 receptor,expressed on spinal commissural axons and processing netrin-1 binding activity,inducing
    attraction in axon guidance through its cytoplasmic tail,inducing apoptosis in the absence of its ligand,homolog
    of C elegans UNC-40

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IEA--
    GO:0004888transmembrane signaling receptor activity TAS8861902
    GO:0005042netrin receptor activity IEA--
    GO:0005515protein binding IPI11527412
    GO:0042802identical protein binding IEA--
         
    DCC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DCC:
     Synthetic lethal with c-Myc af 

         9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Dcc):
     behavior/neurological  cellular  digestive/alimentary  mortality/aging  nervous system 
     pigmentation  respiratory system  tumorigenesis  vision/eye 

    DCC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DCC: Dcctm1Wbg Dcctm1.1Nki

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCC

    miRNA
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    miRTarBase miRNAs that target DCC:
    hsa-mir-124-3p (MIRT022668)

    Block miRNA regulation of human, mouse, rat DCC using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCC (see all 138):
    hsa-miR-100* hsa-miR-1224-3p hsa-miR-128 hsa-miR-502-3p hsa-miR-92b hsa-miR-509-3-5p hsa-miR-32 hsa-miR-3139
    SwitchGear 3'UTR luciferase reporter plasmidDCC 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DCC
    Predesigned siRNA for gene silencing in human, mouse, rat DCC

    Gene Editing
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    OriGene ORF clones in mouse, rat for DCC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCC (NM_005215)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCC

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCC_HUMAN, P43146: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    extracellular1
    lysosome1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0030424axon IEA--
    GO:0032584growth cone membrane IEA--

    DCC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DCC About   (see all 13)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Netrin-1 signaling
    Netrin-1 signaling
    Netrin mediated repulsion signals0.00
    DCC mediated attractive signaling0.00
    Role of second messengers in netrin-1 signaling0.00
    2CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Role of DCC in regulating apoptosis0.00
    Apoptosis0.38
    3Cell junction organization
    Cell-Cell communication0.64
    DSCAM interactions0.00
    4L1CAM interactions
    Axon guidance0.63
    Developmental Biology0.63
    5Activation of cAMP-Dependent PKA
    cAMP Pathway0.77

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DCC
        Guidance Cues and Growth Cone Motility
    Netrin Signaling
    cAMP Pathway
    Colorectal Cancer Metastasis
    Signaling by Slit

    1 BioSystems Pathway for DCC
        Integrated Pancreatic Cancer Pathway

    Selected Reactome Pathways for DCC (see all 6)
        Netrin mediated repulsion signals
    Netrin-1 signaling
    Role of DCC in regulating apoptosis
    Role of second messengers in netrin-1 signaling
    DCC mediated attractive signaling


    3 Kegg Pathways  (Kegg details for DCC):
        Axon guidance
    Pathways in cancer
    Colorectal cancer


    DCC for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DCC: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DCC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCC (P431461, 2, 3 ENSP000003891404) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYO10Q9HD671, 2, 3, ENSP000003911064EBI-1222919,EBI-307061 MINT-8199123 MINT-8199598 MINT-8199637 MINT-8199109 MINT-8199139 MINT-8199557 MINT-8199615 MINT-8199775 I2D: score=1 STRING: ENSP00000391106
    RPL5P467771, 3, ENSP000003593454EBI-1222919,EBI-358018 I2D: score=3 STRING: ENSP00000359345
    RPS23P622661, 3, ENSP000002966744EBI-1222919,EBI-353072 I2D: score=1 STRING: ENSP00000296674
    MAZP562701, 3, ENSP000002197824EBI-1222919,EBI-1809742 I2D: score=3 STRING: ENSP00000219782
    RPL28P467791, 3, ENSP000004014504EBI-1222919,EBI-366357 I2D: score=2 STRING: ENSP00000401450
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006915apoptotic process TAS--
    GO:0007409axonogenesis TAS8861902
    GO:0007411axon guidance TAS--

    DCC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCC gene: 
    NM_005215.3  

    Unigene Cluster for DCC:

    Deleted in colorectal carcinoma
    Hs.162025  [show with all ESTs]
    Unigene Representative Sequence: NM_005215
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000442544(uc002lfe.2 uc010dpf.2) ENST00000578080 ENST00000580024
    ENST00000582875 ENST00000304775 ENST00000579349 ENST00000581559 ENST00000579666
    ENST00000582595 ENST00000584710 ENST00000579883 ENST00000581580 ENST00000578949
    ENST00000580146 ENST00000579941 ENST00000579702 ENST00000577224 ENST00000412726(uc010xdr.1)


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    Selected qRT-PCR Assays for microRNAs that regulate DCC (see all 138):
    hsa-miR-100* hsa-miR-1224-3p hsa-miR-128 hsa-miR-502-3p hsa-miR-92b hsa-miR-509-3-5p hsa-miR-32 hsa-miR-3139
    SwitchGear 3'UTR luciferase reporter plasmidDCC 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: DCC (NM_005215)
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      QuantiFast Probe-based Assays in human, mouse, rat DCC

    Additional mRNA sequence: 

    AK302643.1 AK310385.1 BC036524.1 M32292.1 S81335.1 X76132.1 

    10 DOTS entries:

    DT.309434  DT.436610  DT.91645250  DT.432979  DT.91652132  DT.203961  DT.40292346  DT.121087434 
    DT.75188988  DT.75191285 

    Selected AceView cDNA sequences (see all 27):

    AL705537 AI656183 AA904417 BX101501 M32292 AI990787 AI990038 BG771778 
    BI463685 AI425016 BV169651 AA889035 AL044757 BX108694 AI677901 AI138281 
    BI562450 BG193887 AI911162 BG189543 AA888969 BG208261 NM_005215 X76132 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DCC    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
    SP1:                                                                                                                                      -                     
    SP2:                                                                                                        -                                                   

    ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29
    SP1:                              
    SP2:                              


    ECgene alternative splicing isoforms for DCC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCC expression in normal human tissues (normalized intensities)      DCC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTAACAAAAA
    DCC Expression
    About this image


    DCC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 5 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     NULL (Uncategorized)
             Neural rosettes
     
     Eye (Sensory Organs)
             Retina
    DCC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.162025

    UniProtKB/Swiss-Prot: DCC_HUMAN, P43146
    Tissue specificity: Found in axons of the central and peripheral nervous system and in differentiated cell types
    of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus
    producing cells

        Pathway & Disease-focused RT2 Profiler PCR Array including DCC: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DCC gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcc1 , 5 deleted in colorectal carcinoma1, 5 89.68(n)1
    96.48(a)1
      18 (45.24 cM)5
    131761  NM_007831.31  NP_031857.21 
     712587385 
    lizard
    (Anolis carolinensis)
    Reptilia DCC6
    deleted in colorectal carcinoma
    88(a)
    1 ↔ 1
    GL343289.1(568803-1445397)
    African clawed frog
    (Xenopus laevis)
    Amphibia dcca-A2 deleted in colorectal cancer tumor suppressor 76.53(n)    U10986.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dcc1 deleted in colorectal carcinoma 66.24(n)
    73.13(a)
      569360  NM_001034985.1  NP_001030157.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fra3 motor axon guidance netrin receptor 34(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea unc-401 , 3 membrane protein3
    unc-401
    33(a)3
    46.82(n)1
    36.34(a)1
      I(5680370-5691444)3
    1722331  NM_059263.71  NP_491664.11 


    ENSEMBL Gene Tree for DCC (if available)
    TreeFam Gene Tree for DCC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCC gene
    CHL12  NEO12  ROBO12  CNTN52  CNTN42  IGDCC42  NRCAM2  L1CAM2  
    ROBO22  CNTN22  CNTN62  NFASC2  CNTN32  PRTG2  IGDCC32  ROBO32  
    CNTN12  
    16 SIMAP similar genes for DCC using alignment to 14 protein entries:     DCC_HUMAN (see all proteins):
    NEO1    OBSCN    CNTN4    ROBO2    MUSK    PTPRF
    HMCN2    MDGA1    IGDCC3    L1CAM    CDON    NCAM1
    PALLD    PRTG    IGSF9B    KIAA0992

    DCC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCC (see all 28288)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0039094
    A esophageal carcinoma4--see VAR_0039092 M T mis40--------
    VAR_0355114
    A colorectal cancer sample4--see VAR_0355112 F S mis40--------
    VAR_0039114
    A colorectal carcinoma4--see VAR_0039112 P H mis40--------
    rs1810879051,2
    Cuntested150315506(+) TTAAAC/G/TTATGT 1 -- int10--------
    rs1409982731,2
    Cuntested150450290(+) GTTACG/AAGGCG 2 /Q /R mis11Minor allele frequency- A:0.00NA 4538
    rs631659601,2
    C--46726661(+) CAGTA-/GCCTGT 1 -- int10--------
    rs58249301,2
    C--46735998(+) ACTCAG/-TATAA 1 -- int11Minor allele frequency- -:0.50NA 2
    rs725322411,2
    C--46735998(+) ACTCA-/GATATA 1 -- int10--------
    rs356785881,2
    C--46748236(+) TTGGGG/-TGGGG 1 -- int11Minor allele frequency- -:0.00CSA 2
    rs357060801,2
    C--46751971(+) GTGGG-/TTTTTT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DCC (49866542 - 50116542 bp, first 250kb of DCC)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DCC (see all 75):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2717118CNV Deletion23290073
    esv2717113CNV Deletion23290073
    esv2717107CNV Deletion23290073
    esv2717115CNV Deletion23290073
    esv2938CNV Deletion18987735
    esv995021CNV Deletion20482838
    esv2717109CNV Deletion23290073
    esv2717112CNV Deletion23290073
    esv2592738CNV Deletion19546169
    esv2496857CNV Deletion19546169

    Human Gene Mutation Database (HGMD): DCC
    1 Site Specific Mutation Identification with PCR Assay for DCC:
    Cosmic IdAA Change
    106533p.G55E
    SeqTarget long-range PCR primers for resequencing DCC
    DNA2.0 Custom Variant and Variant Library Synthesis for DCC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 120470   
    OMIM disorders: 157600  114500  133239  
    UniProtKB/Swiss-Prot: DCC_HUMAN, P43146
  • Mirror movements 1 (MRMV1) [MIM:157600]: A disorder characterized by contralateral involuntary movements
    that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond
    the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Note=The disease is
    caused by mutations affecting the gene represented in this entry

  • Selected diseases for DCC (see all 36):    About MalaCards
    mirror movements 1    esophageal cancer, somatic    colorectal cancer    colorectal cancer, somatic
    esophagitis    h. pylori infection    balanitis    nephroblastoma
    gallbladder cancer    narcolepsy    diabetic nephropathy    endometrial carcinoma
    bipolar disorder    esophageal squamous cell carcinoma    inflammatory bowel disease    myocardial infarction
    breast and colorectal cancer    parkinson's disease    adenoma    squamous cell carcinoma

    1 disease from the University of Copenhagen DISEASES database for DCC:
    Colorectal cancer

    DCC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genatlas disease: DCC
    colorectal carcinoma,deleted in (see TSG18A) in endometrial carcinoma with lymph node metastasis,and in
    pancreatic carcinomas

    Genetic Association Database (GAD): DCC
    Human Genome Epidemiology (HuGE) Navigator: DCC (21 documents)
    Tumor Gene Database (TGDB): DCC

    Export disorders for DCC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for DCC gene, integrated from 10 sources (see all 104):
    (articles sorted by number of sources associating them with DCC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a chromosome 18q gene that is altered in colorectal cancers. (PubMed id 2294591)1, 2, 3 Fearon E.R....Vogelstein B. (Science 1990)
    2. A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population. (PubMed id 22318345)1, 4 Cha P.C....Nakamura Y. (J. Hum. Genet. 2012)
    3. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PubMed id 21529783)1, 4 Heath A.C....Montgomery G.W. (Biol. Psychiatry 2011)
    4. Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain. (PubMed id 21642953)1, 2 Hirano Y....Hakoshima T. (EMBO J. 2011)
    5. Mutations in DCC cause congenital mirror movements. (PubMed id 20431009)1, 2 Srour M....Rouleau G.A. (Science 2010)
    6. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Genetic analysis of diabetic nephropathy on chromosome 18 in African Americans: linkage analysis and dense SNP mapping. (PubMed id 19690890)1, 4 McDonough C.W....Bowden D.W. (Hum. Genet. 2009)
    10. Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)1, 4 Luke M.M....Psaty B.M. ( a journal of cerebral circulation 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1630 HGNC: 2701 AceView: DCC Ensembl:ENSG00000187323 euGenes: HUgn1630
    ECgene: DCC Kegg: 1630 H-InvDB: DCC

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DCC Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DCC Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DCC gene:
    Search GeneIP for patents involving DCC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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