V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

DCC Gene

protein-coding GIFtS: 69

GC18P048121

deleted in colorectal carcinoma
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CRC18 ^²
CRCR1 ^²
IGDCC1 ^¹, ², ³

Descriptions
Colorectal cancer suppressor ^³
Immunoglobulin superfamily DCC subclass member 1 ^³
Tumor suppressor protein DCC ^³
deleted in colorectal cancer protein ^²
deleted in colorectal carcinoma ^²
immunoglobulin superfamily, DCC subclass, member 1 ^²

External Ids
HGNC: 2701¹
Entrez Gene: 1630²
UniProtKB: P43146³
Ensembl: ENSG00000187323⁷

Search outside databases for aliases for DCC gene

Previous GC identifers: GC18P050053 GC18P049802 GC18P048119

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DCC_HUMAN, P43146

Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal

growth cones in the developing nervous system upon ligand binding. Its association with UNC5

proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required

for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor

gene

Gene Wiki entry for DCC (Deleted_in_Colorectal_Cancer)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DCC gene

Entrez Gene cytogenetic band: 18q21.3 Ensembl cytogenetic band: 18q21.2 HGNC cytogenetic band: 18q21.1

DCC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18P048121: (about GC identifiers)

Start:	48,120,569 bp from pter
End:	49,311,780 bp from pter
Size:	1,191,212 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000018.8 NT_010966.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DCC_HUMAN, P43146 (See protein sequence)

Recommended Name: Netrin receptor DCC precursor

Size: 1447 amino acids; 158457 Da

Subunit: Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D (By

similarity)

Subcellular location: Membrane; Single-pass type I membrane protein

PDB structures from and Proteopedia :

2ED7 (3D)

2ED8 (3D)

2ED9 (3D)

2EDB (3D)

2EDD (3D)

2EDE (3D)

Post-translational modifications:

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation

(Probable)¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005206.2

ENSEMBL proteins:

ENSP00000304146

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DCC)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--
GO:0030424	axon	IEA	--

About this table

Antibodies for DCC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for DCC
	Antibodies from Abcam (DCC), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for DCC

Assays for DCC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P43146

ProtoNet protein and cluster: P43146

3 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB003962 Fibronectin type III repeat signature

IPB010560 Neogenin

UniProtKB/Swiss-Prot: DCC_HUMAN, P43146

Similarity: Belongs to the immunoglobulin superfamily. DCC family

Similarity: Contains 6 fibronectin type-III domains

Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DCC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DCC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005215

Applied Biosystems Silencer® siRNAs for DCC

Sigma-Aldrich siRNA and siRNA Panels for DCC

Sigma-Aldrich shRNA Panels and shRNA for DCC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_005215
Myc/DDK tagged cDNA clone in CMV expression vector: NM_005215
untagged cDNA clone in CMV expression vector: NM_005215

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_005215

UniProtKB/Swiss-Prot: DCC_HUMAN, P43146

Function: Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal

growth cones in the developing nervous system upon ligand binding. Its association with UNC5

proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required

for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor

gene

Genatlas biochemistry entry for DCC:

netrin-1 receptor,expressed on spinal commissural axons and processing netrin-1 binding

activity,inducing attraction in axon guidance through its cytoplasmic tail,inducing apoptosis in

the absence of its ligand,homolog of C elegans UNC-40

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dcc):

behavior/neurological	lethality-prenatal/perinatal	nervous system	pigmentation	respiratory system
tumorigenesis	vision/eye

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003713	transcription coactivator activity	IEA	--
GO:0005042	netrin receptor activity	IEA	--
GO:0005515	protein binding	IPI	12011067

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for DCC (Your Favorite Gene powered by Ingenuity)

Axonal Guidance Signaling

GeneDecks DCC for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for DCC

5/27 Interacting proteins for DCC (P43146¹ ENSP00000304146³) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAZ	P56270¹, ENSP00000313362³	EBI-1222919, EBI-1809742 STRING (score=.917)
NTN1	ENSP00000173229³	STRING (score=.999)
PTK2	ENSP00000341189³	STRING (score=.979)
UNC5B	ENSP00000334329³	STRING (score=.964)
CASP3	ENSP00000311032³	STRING (score=.948)

About this table

5/7 Gene Ontology (GO) biological process terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001764	neuron migration	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0006917	induction of apoptosis	TAS	9796814
GO:0007275	multicellular organismal development	IEA	--
GO:0007411	axon guidance	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DCC

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DCC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DCC)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005215

Sigma-Aldrich siRNA and siRNA Panels for DCC

Sigma-Aldrich shRNA Panels and shRNA for DCC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_005215

REFSEQ mRNAs for DCC gene:

NM_005215.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_005215

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005215
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_005215
                                 untagged cDNA clone in CMV expression vector: NM_005215

Additional cDNA sequence:

AK302643.1 AK310385.1 BC036524.1 M32292.1 S81335.1 X76132.1

7 DOTS entries:

DT.309434 DT.91645250 DT.432979 DT.91652132 DT.121087434 DT.75188988 DT.75191285

24/27 AceView cDNA sequences (see all 27 ):

AA904417 AI656183 AL705537 M32292 BX101501 AI990787 BI463685 AI425016

AI138281 BX108694 BG771778 BV169651 AL044757 AI677901 AA889035 AI990038

AI911162 BI562450 BG193887 AA888969 BG189543 BG208261 AA609059 CO249615

highest scoring ESTs for DCC:

AA907540 AI377843 AW188046 AW873579 X76132 AL044757 AW949550 AW949555 BG771778 BI463685

Unigene Cluster for DCC:

Deleted in colorectal carcinoma

Hs.579550 [show with all ESTs]

Unigene Representative Sequence: NM_005215

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for DCC

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23	^	24	^
SP1:																																													-
SP2:																																			-

ExUns:	25	^	26	^	27	^	28	^	29
SP1:
SP2:

About this scheme

ECgene alternative splicing isoforms for DCC

1 Ensembl transcript including schematic representation:

ENST00000304775

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DCC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DCC

¹ / ² / ³

4 probe-sets matching DCC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32890_at²^{, 3}	U95-A	1	0.88	1.00	0.02	0.32	X76132	0.80	1.00	0.91	1
80344_at*²^{, 3}	U95-E	1	--	--	1.00	1.00	AI990787	0.20	1.00	0.72	1
206939_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_005215	0.60	1.00	0.82	1
206939_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GTAACAAAAA

SOURCE GeneReport for Unigene cluster: Hs.579550
Expression variation in blood from EXPOLDB for DCC
UniProtKB/Swiss-Prot: DCC_HUMAN, P43146
Tissue specificity: Found in axons of the central and peripheral nervous system and in
differentiated cell types of the intestine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DCC gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DCC¹	--	deleted in colorectal carcinoma	92.36(n) 96.65(a)	483976 XM_541094.2 XP_541094.2
chimpanzee (Pan troglodytes)	DCC¹	--	deleted in colorectal carcinoma	99.59(n) 99.86(a)	455425 XM_512137.2 XP_512137.2
cow (Bos taurus)	DCC¹	--	deleted in colorectal carcinoma	90.48(n) 96.38(a)	537176 XM_617332.3 XP_617332.3
rat (Rattus norvegicus)	Dcc¹	--	deleted in colorectal carcinoma	89.53(n) 96.54(a)	25311 NM_012841.1 NP_036973.1
mouse (Mus musculus)	Dcc^{1, 5}	18 (45.00 cM)⁵	deleted in colorectal carcinoma^{1, 5}	89.68(n)¹ 96.48(a)¹	13176¹ NM_007831.3¹ NP_031857.2¹ AK021125⁵ AK043657⁵ (see all 13)

About this table Species with no ortholog for DCC

ENSEMBL Gene Tree for DCC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DCC gene

BOC² CDON² NEO1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/8235 NCBI SNPs in DCC are shown (see all 8235 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 2605)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs934345^1,2	A,C,F,H,O	48118859(+)	`TTAAAG/CAGCAT`	1	--	ng5¹		16	EA NA EU WA	1412
	rs2229080^1,2	A,C,F,H,O	48686600(+)	`TCAGCC/GGACTC`	1	R/G	mis¹ ese³		18	MN EA NA EU WA	1518
	rs984274^1,2	C,F,H,O	49190933(-)	`ATACAT/CAGTAT`	1	V/M	mis¹ ese³		13	EU EA WA MN NA	1086
	rs2270954^1,2	C,F,H	49311296(+)	`TAGTCC/ATGGGC`	1	--	ut3¹		13	EA EU WA	2756
	rs16954714^1,2	C,F,H	48118630(+)	`CAGATC/GTGAGC`	1	--	ng5¹		11	NA EU EA WA	980
	rs9951523^1,2	C,F,H	48121222(+)	`CCTTGC/TTCAGC`	1	F/L	mis¹ ese³		8	EU EA WA	834
	rs17753970^1,2	C,F,H	48119269(+)	`CTCACG/ACCTTT`	1	--	ng5¹		11	NA EU EA WA	974
	rs2278339^1,2	F,H	49120193(-)	`CCGATA/CATATA`	1	I/M	mis¹		4	EU EA WA	406
	rs16954718^1,2	F,H	48120267(+)	`AAACAC/GGGTCG`	1	--	ng5¹		7	NA EU EA WA	550
	rs17747321^1,2	F,H	48120781(+)	`CATCTC/GCTCTT`	1	--	ut5¹		7	NA EU EA WA	562

About this table

HapMap Linkage Disequilibrium images for DCC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 120470

UniProtKB/Swiss-Prot: DCC_HUMAN, P43146

Colorectal tumors that lost their capacity to differentiate into mucus producing cells

uniformly lack DCC expression. Inactivation of DCC due to allelic deletion and/or point mutations

may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas

Genatlas disease: DCC

colorectal carcinoma,deleted in (see TSG18A) in endometrial carcinoma with lymph node

metastasis,and in pancreatic carcinomas

Human Gene Mutation Database: DCC
Genetic Association Database: DCC
Human Genome Epidemiology Navigator: DCC (11 documents)
Tumor Gene Database: DCC
Breast Cancer Gene Database: DCC

(Possibly Related Articles in Doctor's Guide)
About This Section

Molecules That Guide Nerve Growth May Help Repair Damaged Spinal Nerves

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/62 PubMed articles for DCC gene (see all 62 ):

Identification of a chromosome 18q gene that is altered in colorectal cancers. (PubMed id 2294591)^{2, 3, 4} Fearon E.R....Vogelstein B. (1990)
Genotype phenotype correlations in Israeli colorectal cancer patients. (PubMed id 15523694)^{3, 6} Starinsky S....Friedman E. (2005)
No association between the Arg201Gly polymorphism of the DCC gene and colorectal cancer. (PubMed id 15646429)^{3, 6} de Jong M.M....Kleibeuker J.H. (2004)
The deleted in colorectal carcinoma (DCC) gene 201 R --> G polymorphism: no evidence for genetic association with autoimmune disease. (PubMed id 14571268)^{3, 6} Hall R.J....Merriman T.R. (2003)
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. (PubMed id 9334332)^{3, 4} Hu G....Fearon E.R. (1997)
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor. (PubMed id 8861902)^{3, 4} Keino-Masu K.... Tessier-Lavigne M. (1996)
Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. (PubMed id 8187090)^{3, 4} Miyake S.... Yuasa Y. (1994)
The DCC gene product in cellular differentiation and colorectal tumorigenesis. (PubMed id 7926722)^{3, 4} Hedrick L....Vogelstein B. (1994)
The DCC gene: structural analysis and mutations in colorectal carcinomas. (PubMed id 8188295)^{3, 4} Cho K.R.... Vogelstein B. (1994)
Scrambled exons. (PubMed id 1991322)^{3, 4} Nigro J.M.... Vogelstein B. (1991)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1630	HGNC: 2701	AceView: DCC	Ensembl:ENSG00000187323	euGenes: HUgn1630
ECgene: DCC	H-InvDB: DCC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DCC	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DCC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DCC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DCC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DCC		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DCC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Search for Antibodies
	Chimera RNAi (DCC)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (DCC)
	Antibodies (DCC)

Search OriGene for DCC

Search Tocris compounds for DCC

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for DCC

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
DCC Gene at Home site.
Version 2.41.1
server4.xennexinc.com

DCC Gene

protein-coding GIFtS: 69

Aliases &
Descriptions
for DCC

Summaries
for DCC

Genomic Location
for DCC

Proteins
for DCC

Protein Domains/
Families
for DCC

Gene Function
for DCC

Pathways & Interactions
for DCC

Drugs & Compounds
for DCC

Transcripts
for DCC

Expression
for DCC

Orthologs
for DCC

Paralogs
for DCC

SNPs/Variants
for DCC

Disorders & Mutations
for DCC

Medical News
for DCC

Publications
for DCC

Search for DCC

Genome Databases showing DCC

Other Databases showing DCC

Specialized Databases showing DCC

Licensable Technologies
for DCC

Services
for DCC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DCC Gene

protein-coding GIFtS: 69

Aliases & Descriptionsfor DCC

Summariesfor DCC

Genomic Locationfor DCC

Proteinsfor DCC

Protein Domains/Familiesfor DCC

Gene Functionfor DCC

Pathways & Interactionsfor DCC

Drugs & Compoundsfor DCC

Transcriptsfor DCC

Expression for DCC

Orthologsfor DCC

Paralogsfor DCC

SNPs/Variantsfor DCC

Disorders & Mutationsfor DCC

Medical Newsfor DCC

Publicationsfor DCC

Search for DCC

Genome Databases showing DCC

Other Databases showing DCC

Specialized Databases showing DCC

Licensable Technologiesfor DCC

Servicesfor DCC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DCC

Summaries
for DCC

Genomic Location
for DCC

Proteins
for DCC

Protein Domains/
Families
for DCC

Gene Function
for DCC

Pathways & Interactions
for DCC

Drugs & Compounds
for DCC

Transcripts
for DCC

Expression
for DCC

Orthologs
for DCC

Paralogs
for DCC

SNPs/Variants
for DCC

Disorders & Mutations
for DCC

Medical News
for DCC

Publications
for DCC

Licensable Technologies
for DCC

Services
for DCC