Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCC Gene

Aliases for DCC Gene

  • DCC Netrin 1 Receptor 2 3 5
  • Immunoglobulin Superfamily DCC Subclass Member 1 3 4
  • Deleted In Colorectal Carcinoma 2 3
  • Colorectal Cancer Suppressor 3 4
  • Tumor Suppressor Protein DCC 3 4
  • IGDCC1 3 4
  • Immunoglobulin Superfamily, DCC Subclass, Member 1 3
  • Deleted In Colorectal Cancer Protein 3
  • Putative Colorectal Tumor Suppressor 3
  • Colorectal Tumor Suppressor 3
  • Immunoglobulin Superfamily 2
  • DCC Subclass 2
  • Member 1 2
  • NTN1R1 3
  • CRC18 3
  • CRCR1 3
  • MRMV1 3

External Ids for DCC Gene

Previous GeneCards Identifiers for DCC Gene

  • GC18P050053
  • GC18P049802
  • GC18P048119
  • GC18P048121
  • GC18P046722

Summaries for DCC Gene

Entrez Gene Summary for DCC Gene

  • This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]

GeneCards Summary for DCC Gene

DCC (DCC Netrin 1 Receptor) is a Protein Coding gene. Diseases associated with DCC include mirror movements 1 and colorectal cancer. Among its related pathways are Integrated Pancreatic Cancer Pathway and Developmental Biology. GO annotations related to this gene include identical protein binding and transmembrane signaling receptor activity. An important paralog of this gene is IGDCC3.

UniProtKB/Swiss-Prot for DCC Gene

  • Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Gene Wiki entry for DCC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCC Gene

Genomics for DCC Gene

Regulatory Elements for DCC Gene

Genomic Location for DCC Gene

Chromosome:
18
Start:
52,340,172 bp from pter
End:
53,535,903 bp from pter
Size:
1,195,732 bases
Orientation:
Plus strand

Genomic View for DCC Gene

Genes around DCC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCC Gene

Proteins for DCC Gene

  • Protein details for DCC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P43146-DCC_HUMAN
    Recommended name:
    Netrin receptor DCC
    Protein Accession:
    P43146

    Protein attributes for DCC Gene

    Size:
    1447 amino acids
    Molecular mass:
    158457 Da
    Quaternary structure:
    • Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with DSCAM. Interacts with PTK2/FAK1 and MAPK1. Interacts with NTN1 (By similarity). Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity).
    Miscellaneous:
    • Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and hematogenous metastatic tumor dissemination.
    SequenceCaution:
    • Sequence=AAA52175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAA52177.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA52179.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAA52180.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCC Gene

neXtProt entry for DCC Gene

Proteomics data for DCC Gene at MOPED

Post-translational modifications for DCC Gene

  • Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
  • Glycosylation at Asn 94, Asn 299, Asn 318, Asn 478, Asn 628, and Asn 702
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DCC Gene

Domains & Families for DCC Gene

Suggested Antigen Peptide Sequences for DCC Gene

Graphical View of Domain Structure for InterPro Entry

P43146

UniProtKB/Swiss-Prot:

DCC_HUMAN :
  • Contains 6 fibronectin type-III domains.
  • Belongs to the immunoglobulin superfamily. DCC family.
Domain:
  • Contains 6 fibronectin type-III domains.
  • Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. DCC family.
genes like me logo Genes that share domains with DCC: view

Function for DCC Gene

Molecular function for DCC Gene

GENATLAS Biochemistry:
netrin-1 receptor,expressed on spinal commissural axons and processing netrin-1 binding activity,inducing attraction in axon guidance through its cytoplasmic tail,inducing apoptosis in the absence of its ligand,homolog of C elegans UNC-40
UniProtKB/Swiss-Prot Function:
Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
genes like me logo Genes that share phenotypes with DCC: view

Human Phenotype Ontology for DCC Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DCC Gene

MGI Knock Outs for DCC:

Animal Model Products

  • Taconic Biosciences Mouse Models for DCC

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for DCC Gene

Localization for DCC Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCC Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCC Gene COMPARTMENTS Subcellular localization image for DCC gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 1
extracellular 1
lysosome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DCC Gene

Pathways & Interactions for DCC Gene

genes like me logo Genes that share pathways with DCC: view

Gene Ontology (GO) - Biological Process for DCC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0006915 apoptotic process TAS 9796814
GO:0012501 programmed cell death TAS --
GO:0021965 spinal cord ventral commissure morphogenesis IEA --
GO:0033564 anterior/posterior axon guidance IEA --
genes like me logo Genes that share ontologies with DCC: view

No data available for SIGNOR curated interactions for DCC Gene

Drugs & Compounds for DCC Gene

No Compound Related Data Available

Transcripts for DCC Gene

Unigene Clusters for DCC Gene

Deleted in colorectal carcinoma:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCC Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22 ^ 23 ^ 24 ^
SP1: -
SP2: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29
SP1:
SP2:

Relevant External Links for DCC Gene

GeneLoc Exon Structure for
DCC
ECgene alternative splicing isoforms for
DCC

Expression for DCC Gene

mRNA expression in normal human tissues for DCC Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DCC Gene

This gene is overexpressed in Testis (x18.0) and Brain - Nucleus accumbens (basal ganglia) (x4.8).

Protein differential expression in normal tissues from HIPED for DCC Gene

This gene is overexpressed in Fetal Brain (62.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCC Gene



SOURCE GeneReport for Unigene cluster for DCC Gene Hs.162025

mRNA Expression by UniProt/SwissProt for DCC Gene

P43146-DCC_HUMAN
Tissue specificity: Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
genes like me logo Genes that share expression patterns with DCC: view

Protein tissue co-expression partners for DCC Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for DCC Gene

This gene was present in the common ancestor of animals.

Orthologs for DCC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCC 35
  • 99.59 (n)
  • 99.86 (a)
DCC 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCC 35
  • 90.92 (n)
  • 96.68 (a)
dog
(Canis familiaris)
Mammalia DCC 35
  • 93.01 (n)
  • 97.53 (a)
DCC 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcc 36
  • 96 (a)
OneToOne
Dcc 16
Dcc 35
  • 89.68 (n)
  • 96.48 (a)
oppossum
(Monodelphis domestica)
Mammalia DCC 36
  • 92 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dcc 35
  • 89.53 (n)
  • 96.54 (a)
lizard
(Anolis carolinensis)
Reptilia DCC 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dcca-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dcc 35
  • 75.71 (n)
  • 82.63 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01100973.1 36
  • 78 (a)
OneToMany
DCC (2 of 2) 36
  • 62 (a)
OneToMany
dcc 35
  • 66.24 (n)
  • 73.13 (a)
fruit fly
(Drosophila melanogaster)
Insecta fra 36
  • 30 (a)
OneToMany
fra 37
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-40 37
  • 33 (a)
unc-40 35
  • 46.82 (n)
  • 36.34 (a)
unc-40 36
  • 30 (a)
OneToMany
Species with no ortholog for DCC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCC Gene

ENSEMBL:
Gene Tree for DCC (if available)
TreeFam:
Gene Tree for DCC (if available)

Paralogs for DCC Gene

Paralogs for DCC Gene

genes like me logo Genes that share paralogs with DCC: view

Variants for DCC Gene

Sequence variations from dbSNP and Humsavar for DCC Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
VAR_003909 A esophageal carcinoma
rs2229080 - 52,906,232(+) TCAGC(C/G)GACTC reference, missense
VAR_003911 A colorectal carcinoma
rs984274 - 53,410,565(-) ATACA(C/T)AGTAT reference, missense
VAR_035511 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for DCC Gene

Variant ID Type Subtype PubMed ID
esv275550 CNV Loss 21479260
esv22158 CNV Loss 19812545
esv1534314 CNV Insertion 17803354
nsv833657 CNV Loss 17160897
nsv2308 CNV Insertion 18451855
esv272016 CNV Insertion 20981092
nsv521063 CNV Loss 19592680
esv2672905 CNV Deletion 23128226
esv267489 CNV Insertion 20981092
nsv515816 CNV Gain 19592680
nsv458076 CNV Gain 19166990
esv2717105 CNV Deletion 23290073
nsv909650 CNV Loss 21882294
esv270128 CNV Insertion 20981092
esv273444 CNV Insertion 20981092
esv2657510 CNV Deletion 23128226
nsv458079 CNV Loss 19166990
nsv516994 CNV Loss 19592680
nsv521932 CNV Loss 19592680
esv2717107 CNV Deletion 23290073
esv2938 CNV Deletion 18987735
esv2717108 CNV Deletion 23290073
esv273869 CNV Insertion 20981092
esv269222 CNV Insertion 20981092
esv2717109 CNV Deletion 23290073
esv2717110 CNV Deletion 23290073
esv2592738 CNV Deletion 19546169
esv2108318 CNV Deletion 18987734
esv23617 CNV Loss 19812545
esv1007284 CNV Loss 20482838
nsv828236 CNV Loss 20364138
esv2717111 CNV Deletion 23290073
esv6032 CNV Loss 19470904
esv2675658 CNV Deletion 23128226
nsv131400 CNV Loss 16902084
esv2518546 CNV Deletion 19546169
nsv2309 CNV Insertion 18451855
esv2251611 CNV Deletion 18987734
esv2717112 CNV Deletion 23290073
esv4836 CNV Deletion 18987735
esv9355 CNV Loss 19470904
nsv130811 CNV Loss 16902084
nsv458080 CNV Loss 19166990
nsv909651 CNV Gain 21882294
esv275215 CNV Loss 21479260
esv2666866 CNV Deletion 23128226
esv1388943 CNV Deletion 17803354
nsv528217 CNV Loss 19592680
esv2717113 CNV Deletion 23290073
esv2252212 CNV Deletion 18987734
esv2717114 CNV Deletion 23290073
esv1146191 CNV Insertion 17803354
esv2717115 CNV Deletion 23290073
nsv909652 CNV Gain 21882294
esv2653679 CNV Deletion 19546169
nsv828237 CNV Gain 20364138
nsv828238 CNV Loss 20364138
esv1010861 CNV Loss 20482838
nsv507872 CNV Insertion 20534489
esv2496857 CNV Deletion 19546169
esv2111490 CNV Deletion 18987734
esv4954 CNV Deletion 18987735
esv7831 CNV Loss 19470904
esv995021 CNV Deletion 20482838
esv1682692 CNV Deletion 17803354
esv2717116 CNV Deletion 23290073
esv2717118 CNV Deletion 23290073
nsv507873 CNV Insertion 20534489
esv2675439 CNV Deletion 23128226
nsv510457 CNV Loss 20534489
esv268292 CNV Insertion 20981092
esv274482 CNV Insertion 20981092
esv1008613 CNV Insertion 20482838
nsv510741 CNV Loss 20534489
nsv2311 CNV Insertion 18451855

Variation tolerance for DCC Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.80; 96.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCC Gene

HapMap Linkage Disequilibrium report
DCC
Human Gene Mutation Database (HGMD)
DCC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCC Gene

Disorders for DCC Gene

MalaCards: The human disease database

(6) MalaCards diseases for DCC Gene - From: OMIM, ClinVar, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
mirror movements 1
  • congenital mirror movements
colorectal cancer
  • colorectal cancer, somatic
esophageal cancer
  • esophageal cancer, somatic
ureter adenocarcinoma
  • adenocarcinoma of ureter
gastric squamous cell carcinoma
  • squamous cell carcinoma of stomach
- elite association - COSMIC cancer census association via MalaCards
Search DCC in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DCC_HUMAN
  • Mirror movements 1 (MRMV1) [MIM:157600]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. {ECO:0000269 PubMed:20431009}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for DCC Gene

colorectal carcinoma,deleted in (see TSG18A) in endometrial carcinoma with lymph node metastasis,and in pancreatic carcinomas

Relevant External Links for DCC

Genetic Association Database (GAD)
DCC
Human Genome Epidemiology (HuGE) Navigator
DCC
Tumor Gene Database (TGDB):
DCC
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCC
genes like me logo Genes that share disorders with DCC: view

Publications for DCC Gene

  1. Identification of a chromosome 18q gene that is altered in colorectal cancers. (PMID: 2294591) Fearon E.R. … Vogelstein B. (Science 1990) 2 3 4 67
  2. Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor. (PMID: 24400119) Haddick P.C. … Gonzalez L.C. (PLoS ONE 2014) 2 3
  3. Misregulation of the dependence receptor DCC and its upstream lincRNA, LOC100287225, in colorectal cancer. (PMID: 26429648) Kazemzadeh M. … Shokoohi B. (Tumori 2015) 3
  4. A Floor-Plate Extracellular Protein-Protein Interaction Screen Identifies Draxin as a Secreted Netrin-1 Antagonist. (PMID: 26190107) Gao X. … SAPllner C. (Cell Rep 2015) 3
  5. Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer). (PMID: 25575591) Deming P.B. … Howe A.K. (J. Biol. Chem. 2015) 3

Products for DCC Gene

Sources for DCC Gene

Back to Top

Content