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Aliases & Descriptions for DCBLD2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| 1700055P21Rik 2 | | CLCP1 1, 2, 3 | | ESDN 1, 2, 3 |
| | | Descriptions |
|---|
CUB, LCCL and coagulation factor V/VIII-homology domains protein 1 3 | Endothelial and smooth muscle cell-derived neuropilin-like protein 2, 3 | | coagulation factor V/VIII-homology domains protein 1 2 | | discoidin, CUB and LCCL domain containing 2 2 |
|
| | Search outside databases for aliases for DCBLD2 genePrevious GC identifer: GC03M099836 |
Summaries for DCBLD2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for DCBLD2 |
Genomic Location for DCBLD2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DCBLD2 gene 
Entrez Gene cytogenetic band: 3q12.1|3 Ensembl cytogenetic band: 3q12.1 HGNC cytogenetic band: 3q12.2DCBLD2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M099997:
(about GC identifiers)
Start:
|
99,997,504 bp from pter |
End:
|
100,103,223 bp from pter |
Size:
|
105,720 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_005612.15
| Proteins for DCBLD2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DCBD2_HUMAN, Q96PD2 (See
protein sequence)Recommended Name: Discoidin, CUB and LCCL domain-containing protein 2 precursor Size: 775 amino acids; 85035 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q8N6M4 Q8TDX2Alternative splicing: 2 isoforms: Q96PD2-1 Q96PD2-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_563615.3
ENSEMBL proteins: ENSP00000385656 ENSP00000321573 ENSP00000321646
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for DCBLD2: Assays for DCBLD2: | Protein
Domains/ Families for DCBLD2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96PD2
ProtoNet protein and cluster: Q96PD2 2 Blocks protein families: IPB000421 Coagulation factor 5/8 type C domain (FA58C) IPB000859 CUB domain
UniProtKB/Swiss-Prot: DCBD2_HUMAN, Q96PD2Similarity: Contains 1 CUB domainSimilarity: Contains 1 F5/8 type C domainSimilarity: Contains 1 LCCL domain | Gene Function for DCBLD2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080927
Applied Biosystems Silencer® siRNAs for DCBLD2
Sigma-Aldrich siRNA and siRNA Panels for DCBLD2  Sigma-Aldrich shRNA for DCBLD2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080927                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080927                                  untagged cDNA clone in CMV expression vector: NM_080927 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_080927
UniProtKB/Swiss-Prot: DCBD2_HUMAN, Q96PD2Induction: Increased in lung cancers during the process of tumor progression1 Gene Ontology (GO) molecular function term (links to tree view): About this table | Pathways & Interactions for DCBLD2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for DCBLD2 (ENSP000003215733) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for DCBLD2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for DCBLD2
|
Transcripts for DCBLD2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080927
Sigma-Aldrich siRNA and siRNA Panels for DCBLD2  Sigma-Aldrich shRNA for DCBLD2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_080927 REFSEQ mRNAs for DCBLD2 gene: NM_080927.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_080927               OriGene GFP tagged cDNA clone in CMV expression vector: NM_080927                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080927                                  untagged cDNA clone in CMV expression vector: NM_080927  Additional cDNA sequence: AB073146.1 AF104313.1 AF387547.1 AK001362.1 AK056350.1 AK302649.1 BC007117.1 BC016815.1 BC029658.1 BX647140.1 D29810.1 12 DOTS entries: DT.100028579 DT.102833519 DT.95179834 DT.75123629 DT.92056600 DT.99974173 DT.102833520 DT.120914541 DT.40257901 DT.416993 DT.86848429 DT.97765306 24/278 AceView cDNA sequences (see all 278
):AI695876 BU753325 AW138866 AA128681 AI220745 AI802905 AI242761 BU171889 AA782668 BU628593 AA885289 AV682179 AI499115 NM_080927 AI656521 BM468461 BM984345 CB144123 AI379718 BU631293 AF387547 AI654989 BE708542 BU687616
highest scoring ESTs for DCBLD2:AI262981 AI220745 AI433228 AI864669 AW300360 AW611673 BG433690 BG722378 H80005 H85099 Unigene Cluster for DCBLD2: Discoidin, CUB and LCCL domain containing 2 Hs.203691 [show with all ESTs]Unigene Representative Sequence: NM_080927
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DCBLD2
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | ^ | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for DCBLD2
3 Ensembl transcripts including schematic representations: ENST00000404023
ENST00000326840
ENST00000326857
|
Expression for DCBLD2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DCBLD2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DCBLD2
1 / 2 / 3 11 probe-sets matching DCBLD2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TACTGTAGTC
SOURCE GeneReport for Unigene cluster: Hs.203691
Expression variation in blood from EXPOLDB for DCBLD2 UniProtKB/Swiss-Prot: DCBD2_HUMAN, Q96PD2Tissue specificity: Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells |
Orthologs for DCBLD2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DCBLD2 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for DCBLD2
ENSEMBL Gene Tree for DCBLD2 | Paralogs for DCBLD2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for DCBLD2 gene
- DCBLD12 RS12
|
SNPs/Variants for DCBLD2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DCBLD2 (up to first 250kb)
|
Disorders & Mutations for DCBLD2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608698
|
Medical News for DCBLD2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DCBLD2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/11 PubMed articles for DCBLD2 gene (see all 11
):- ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. (PubMed id 11447234)1, 2, 3, 4 Kobuke K.... Tashiro K. (2001)
- Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules. (PubMed id 15951569)3, 4 Zhang Y.... White F.M. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo. (PubMed id 11973641)3, 4 Koshikawa K.... Takahashi T. (2002)
- ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis. (PubMed id 17697260)1, 3 Sadeghi M.M....Rodriguez E.R. (2007)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Epigenetic down-regulation and suppressive role of DCBLD2 in gastric cancer cell proliferation and invasion. (PubMed id 18314483)3 Kim M....Kim Y.S. (2008)
- Phosphoproteomics identified Endofin, DCBLD2, and KIAA0582 as novel tyrosine phosphorylation targets of EGF signaling and Iressa in human cancer cells. (PubMed id 17570516)3 Chen Y....Lim Y.P. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
|
Search for DCBLD2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DCBLD2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DCBLD2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCBLD2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for DCBLD2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for DCBLD2:

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Incremental update: 13 Oct 2009
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