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Aliases for DCBLD2 Gene

Aliases for DCBLD2 Gene

  • Discoidin, CUB And LCCL Domain Containing 2 2 3
  • ESDN 3 4 6
  • Endothelial And Smooth Muscle Cell-Derived Neuropilin-Like Protein 3 4
  • CUB, LCCL And Coagulation Factor V/VIII-Homology Domains Protein 1 3 4
  • CLCP1 3 4
  • Coagulation Factor V/VIII-Homology Domains Protein 1 3
  • Discoidin, CUB And LCCL Domain-Containing Protein 2 3
  • 1700055P21Rik 3

External Ids for DCBLD2 Gene

Previous GeneCards Identifiers for DCBLD2 Gene

  • GC03M099836
  • GC03M099997
  • GC03M098514
  • GC03M095886

Summaries for DCBLD2 Gene

GeneCards Summary for DCBLD2 Gene

DCBLD2 (Discoidin, CUB And LCCL Domain Containing 2) is a Protein Coding gene. Among its related pathways are Neuroscience. An important paralog of this gene is NRP2.

Gene Wiki entry for DCBLD2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCBLD2 Gene

Genomics for DCBLD2 Gene

Regulatory Elements for DCBLD2 Gene

Genomic Location for DCBLD2 Gene

98,795,941 bp from pter
98,901,689 bp from pter
105,749 bases
Minus strand

Genomic View for DCBLD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCBLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCBLD2 Gene

Proteins for DCBLD2 Gene

  • Protein details for DCBLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Discoidin, CUB and LCCL domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B7WNL1
    • D3DN41
    • Q8N6M4
    • Q8TDX2

    Protein attributes for DCBLD2 Gene

    775 amino acids
    Molecular mass:
    85035 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCBLD2 Gene


neXtProt entry for DCBLD2 Gene

Proteomics data for DCBLD2 Gene at MOPED

Post-translational modifications for DCBLD2 Gene

  • Ubiquitination at Lys586
  • Glycosylation at Asn95, Asn155, Asn272, Asn474, Thr490, Asn516, and Asn522
  • Modification sites at PhosphoSitePlus

Other Protein References for DCBLD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCBLD2 Gene

Domains for DCBLD2 Gene

Suggested Antigen Peptide Sequences for DCBLD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q96PD2
  • Contains 1 CUB domain.
  • Contains 1 F5/8 type C domain.
  • Contains 1 LCCL domain.
genes like me logo Genes that share domains with DCBLD2: view

No data available for Gene Families for DCBLD2 Gene

Function for DCBLD2 Gene

Molecular function for DCBLD2 Gene

UniProtKB/Swiss-Prot Induction: Increased in lung cancers during the process of tumor progression

Gene Ontology (GO) - Molecular Function for DCBLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 23770091
genes like me logo Genes that share ontologies with DCBLD2: view

Phenotypes for DCBLD2 Gene

GenomeRNAi human phenotypes for DCBLD2:
genes like me logo Genes that share phenotypes with DCBLD2: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCBLD2 Gene

Localization for DCBLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCBLD2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for DCBLD2 Gene COMPARTMENTS Subcellular localization image for DCBLD2 gene
Compartment Confidence
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
endosome 1
extracellular 1
golgi apparatus 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DCBLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 11447234
GO:0009986 cell surface IDA 11447234
genes like me logo Genes that share ontologies with DCBLD2: view

Pathways for DCBLD2 Gene

SuperPathways for DCBLD2 Gene

Superpath Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with DCBLD2: view

Pathways by source for DCBLD2 Gene

1 Cell Signaling Technology pathway for DCBLD2 Gene

Gene Ontology (GO) - Biological Process for DCBLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0030308 negative regulation of cell growth IDA 11447234
GO:0030522 intracellular receptor signaling pathway NAS 11447234
GO:0042060 wound healing IDA 11447234
genes like me logo Genes that share ontologies with DCBLD2: view

Transcripts for DCBLD2 Gene

Unigene Clusters for DCBLD2 Gene

Discoidin, CUB and LCCL domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCBLD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - -
SP2: - -
SP4: -

Relevant External Links for DCBLD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCBLD2 Gene

mRNA expression in normal human tissues for DCBLD2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCBLD2 Gene

SOURCE GeneReport for Unigene cluster for DCBLD2 Gene Hs.203691

mRNA Expression by UniProt/SwissProt for DCBLD2 Gene

Tissue specificity: Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells.
genes like me logo Genes that share expressions with DCBLD2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DCBLD2 Gene

Orthologs for DCBLD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCBLD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCBLD2 35
  • 99.61 (n)
  • 99.61 (a)
  • 100 (a)
(Bos Taurus)
Mammalia DCBLD2 35
  • 89.55 (n)
  • 91.48 (a)
  • 91 (a)
(Canis familiaris)
Mammalia DCBLD2 35
  • 91.1 (n)
  • 94.77 (a)
  • 93 (a)
(Mus musculus)
Mammalia Dcbld2 35
  • 85.48 (n)
  • 84.62 (a)
Dcbld2 16
Dcbld2 36
  • 85 (a)
(Monodelphis domestica)
Mammalia DCBLD2 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
-- 36
  • 71 (a)
(Rattus norvegicus)
Mammalia Dcbld2 35
  • 85.88 (n)
  • 86.05 (a)
(Gallus gallus)
Aves DCBLD2 35
  • 74.51 (n)
  • 76.78 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia DCBLD2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcbld2 35
  • 69.15 (n)
  • 71.09 (a)
(Danio rerio)
Actinopterygii dcbld2 36
  • 56 (a)
Species with no ortholog for DCBLD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCBLD2 Gene

Gene Tree for DCBLD2 (if available)
Gene Tree for DCBLD2 (if available)

Paralogs for DCBLD2 Gene

Paralogs for DCBLD2 Gene

Selected SIMAP similar genes for DCBLD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DCBLD2: view

Variants for DCBLD2 Gene

Sequence variations from dbSNP and Humsavar for DCBLD2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs8833 -- 98,796,725(+) ATTTA(C/T)AGCAT utr-variant-3-prime
rs278377 -- 98,813,571(-) CCTGA(A/G)CAGCA intron-variant
rs278378 -- 98,812,602(+) TATGA(C/T)AATAA intron-variant
rs278379 -- 98,810,320(-) TTACT(C/T)TCTCA intron-variant
rs278380 -- 98,810,063(+) TCTTT(C/G)TTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCBLD2 Gene

Variant ID Type Subtype PubMed ID
nsv877214 CNV Gain 21882294
nsv509842 CNV Loss 20534489
esv2606873 CNV Deletion 19546169

Relevant External Links for DCBLD2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCBLD2 Gene

Disorders for DCBLD2 Gene

Relevant External Links for DCBLD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DCBLD2: view

No data available for UniProtKB/Swiss-Prot for DCBLD2 Gene

Publications for DCBLD2 Gene

  1. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. (PMID: 11447234) Kobuke K. … Tashiro K. (J. Biol. Chem. 2001) 2 3 4 23
  2. ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis. (PMID: 17697260) Sadeghi M.M. … Rodriguez E.R. (Am. J. Transplant. 2007) 3 23
  3. Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. (PMID: 19696027) Guo X. … Sadeghi M.M. (J. Biol. Chem. 2009) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo. (PMID: 11973641) Koshikawa K. … Takahashi T. (Oncogene 2002) 3 4

Products for DCBLD2 Gene

Sources for DCBLD2 Gene

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