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Aliases for DCBLD2 Gene

Aliases for DCBLD2 Gene

  • Discoidin, CUB And LCCL Domain Containing 2 2 3 5
  • Endothelial And Smooth Muscle Cell-Derived Neuropilin-Like Protein 3 4
  • CUB, LCCL And Coagulation Factor V/VIII-Homology Domains Protein 1 3 4
  • CLCP1 3 4
  • ESDN 3 4
  • Coagulation Factor V/VIII-Homology Domains Protein 1 3
  • 1700055P21Rik 3

External Ids for DCBLD2 Gene

Previous GeneCards Identifiers for DCBLD2 Gene

  • GC03M099836
  • GC03M099997
  • GC03M098514
  • GC03M095886

Summaries for DCBLD2 Gene

GeneCards Summary for DCBLD2 Gene

DCBLD2 (Discoidin, CUB And LCCL Domain Containing 2) is a Protein Coding gene. Diseases associated with DCBLD2 include X-Linked Nonsyndromic Deafness and Diverticulitis. Among its related pathways are Neuroscience. An important paralog of this gene is NRP2.

Gene Wiki entry for DCBLD2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCBLD2 Gene

Genomics for DCBLD2 Gene

Regulatory Elements for DCBLD2 Gene

Enhancers for DCBLD2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCBLD2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCBLD2 Gene

98,795,941 bp from pter
98,901,689 bp from pter
105,749 bases
Minus strand

Genomic View for DCBLD2 Gene

Genes around DCBLD2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCBLD2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCBLD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCBLD2 Gene

Proteins for DCBLD2 Gene

  • Protein details for DCBLD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Discoidin, CUB and LCCL domain-containing protein 2
    Protein Accession:
    Secondary Accessions:
    • B7WNL1
    • D3DN41
    • Q8N6M4
    • Q8TDX2

    Protein attributes for DCBLD2 Gene

    775 amino acids
    Molecular mass:
    85035 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCBLD2 Gene


neXtProt entry for DCBLD2 Gene

Proteomics data for DCBLD2 Gene at MOPED

Post-translational modifications for DCBLD2 Gene

  • Ubiquitination at Lys 586
  • Glycosylation at Asn 95, Asn 155, Asn 272, Asn 474, Thr 490, Asn 516, and Asn 522
  • Modification sites at PhosphoSitePlus

Other Protein References for DCBLD2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DCBLD2 (DCBLD2)

No data available for DME Specific Peptides for DCBLD2 Gene

Domains & Families for DCBLD2 Gene

Protein Domains for DCBLD2 Gene

Suggested Antigen Peptide Sequences for DCBLD2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 CUB domain.
  • Contains 1 CUB domain.
  • Contains 1 F5/8 type C domain.
  • Contains 1 LCCL domain.
genes like me logo Genes that share domains with DCBLD2: view

No data available for Gene Families for DCBLD2 Gene

Function for DCBLD2 Gene

Molecular function for DCBLD2 Gene

UniProtKB/Swiss-Prot Induction:
Increased in lung cancers during the process of tumor progression.
genes like me logo Genes that share phenotypes with DCBLD2: view

Animal Models for DCBLD2 Gene

MGI Knock Outs for DCBLD2:

Animal Model Products

  • Taconic Biosciences Mouse Models for DCBLD2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCBLD2 Gene

Localization for DCBLD2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCBLD2 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for DCBLD2 Gene COMPARTMENTS Subcellular localization image for DCBLD2 gene
Compartment Confidence
plasma membrane 5
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
endosome 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DCBLD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 11447234
genes like me logo Genes that share ontologies with DCBLD2: view

Pathways & Interactions for DCBLD2 Gene

SuperPathways for DCBLD2 Gene

Superpath Contained pathways
1 Neuroscience
genes like me logo Genes that share pathways with DCBLD2: view

Pathways by source for DCBLD2 Gene

1 Cell Signaling Technology pathway for DCBLD2 Gene

Gene Ontology (GO) - Biological Process for DCBLD2 Gene


No data available for SIGNOR curated interactions for DCBLD2 Gene

Drugs & Compounds for DCBLD2 Gene

No Compound Related Data Available

Transcripts for DCBLD2 Gene

Unigene Clusters for DCBLD2 Gene

Discoidin, CUB and LCCL domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCBLD2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b · 16c
SP1: - - -
SP2: - -
SP4: -

Relevant External Links for DCBLD2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCBLD2 Gene

mRNA expression in normal human tissues for DCBLD2 Gene

Protein differential expression in normal tissues from HIPED for DCBLD2 Gene

This gene is overexpressed in Liver (44.9) and Amniocyte (22.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCBLD2 Gene

SOURCE GeneReport for Unigene cluster for DCBLD2 Gene Hs.203691

mRNA Expression by UniProt/SwissProt for DCBLD2 Gene

Tissue specificity: Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells.
genes like me logo Genes that share expression patterns with DCBLD2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for DCBLD2 Gene

Orthologs for DCBLD2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCBLD2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCBLD2 35
  • 89.55 (n)
  • 91.48 (a)
  • 91 (a)
(Canis familiaris)
Mammalia DCBLD2 35
  • 91.1 (n)
  • 94.77 (a)
  • 93 (a)
(Mus musculus)
Mammalia Dcbld2 35
  • 85.48 (n)
  • 84.62 (a)
Dcbld2 16
Dcbld2 36
  • 85 (a)
(Pan troglodytes)
Mammalia DCBLD2 35
  • 99.61 (n)
  • 99.61 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Dcbld2 35
  • 85.88 (n)
  • 86.05 (a)
(Monodelphis domestica)
Mammalia DCBLD2 36
  • 83 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
-- 36
  • 71 (a)
(Gallus gallus)
Aves DCBLD2 35
  • 74.51 (n)
  • 76.78 (a)
  • 75 (a)
(Anolis carolinensis)
Reptilia DCBLD2 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcbld2 35
  • 69.15 (n)
  • 71.09 (a)
(Danio rerio)
Actinopterygii dcbld2 36
  • 56 (a)
Species with no ortholog for DCBLD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCBLD2 Gene

Gene Tree for DCBLD2 (if available)
Gene Tree for DCBLD2 (if available)

Paralogs for DCBLD2 Gene

Paralogs for DCBLD2 Gene

(6) SIMAP similar genes for DCBLD2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DCBLD2: view

Variants for DCBLD2 Gene

Sequence variations from dbSNP and Humsavar for DCBLD2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs9838238 - 98,881,541(+) CTACC(C/T)ATTTC intron-variant, reference, missense
rs16840208 - 98,799,533(+) GCTGT(C/T)AGTCC reference, missense
rs1036674 -- 98,887,260(-) CAGAT(A/G)TATTA intron-variant
rs1062196 -- 98,798,169(-) GTCCT(A/G)TATGT utr-variant-3-prime
rs1062197 -- 98,797,916(-) TCCCT(C/T)TTCCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DCBLD2 Gene

Variant ID Type Subtype PubMed ID
nsv877214 CNV Gain 21882294
nsv509842 CNV Loss 20534489
esv2606873 CNV Deletion 19546169

Variation tolerance for DCBLD2 Gene

Residual Variation Intolerance Score: 82% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.62; 65.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCBLD2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCBLD2 Gene

Disorders for DCBLD2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCBLD2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
x-linked nonsyndromic deafness
  • x-linked deafness
  • diverticulitis nos
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DCBLD2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DCBLD2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCBLD2 Gene

Publications for DCBLD2 Gene

  1. ESDN, a novel neuropilin-like membrane protein cloned from vascular cells with the longest secretory signal sequence among eukaryotes, is up-regulated after vascular injury. (PMID: 11447234) Kobuke K. … Tashiro K. (J. Biol. Chem. 2001) 2 3 4 23 67
  2. Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination. (PMID: 19696027) Guo X. … Sadeghi M.M. (J. Biol. Chem. 2009) 3 23
  3. ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis. (PMID: 17697260) Sadeghi M.M. … Rodriguez E.R. (Am. J. Transplant. 2007) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis. (PMID: 25061874) Feng H. … Cheng S.Y. (J. Clin. Invest. 2014) 3

Products for DCBLD2 Gene

Sources for DCBLD2 Gene