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Aliases for DCBLD1 Gene

Aliases for DCBLD1 Gene

  • Discoidin, CUB And LCCL Domain Containing 1 2 3 5
  • Discoidin, CUB And LCCL Domain-Containing Protein 1 3
  • DJ94G16.1 3

External Ids for DCBLD1 Gene

Previous GeneCards Identifiers for DCBLD1 Gene

  • GC06P117803
  • GC06P117849
  • GC06P117910
  • GC06P115384

Summaries for DCBLD1 Gene

GeneCards Summary for DCBLD1 Gene

DCBLD1 (Discoidin, CUB And LCCL Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include oligosaccharide binding. An important paralog of this gene is DCBLD2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCBLD1 Gene

Genomics for DCBLD1 Gene

Regulatory Elements for DCBLD1 Gene

Enhancers for DCBLD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F117490 0.9 FANTOM5 Ensembl ENCODE 34.9 +41.1 41113 9.1 TAL1 JUN ZMYM3 ZNF316 EED FOS NR2F6 MAFK NR2F1 JUNB DCBLD1 RNU6-253P ENSG00000226181 PIR41328
GH06F117481 0.8 FANTOM5 ENCODE 24.8 +29.0 29014 3.5 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF263 SP3 DCBLD1 RPL29P4 RNU6-253P PIR41328
GH06F117478 0.8 ENCODE 23.3 +24.7 24747 1.1 MLX ARID4B DMAP1 ZNF143 SP5 JUNB MXD4 MIER2 REST PPARG DCBLD1 RNU6-253P PIR41328
GH06F117534 0.6 ENCODE 23.3 +81.6 81554 0.8 RAD21 NR2F2 DCBLD1 ENSG00000226181 RNU6-253P PIR41328 ENSG00000282218
GH06F117505 0.9 Ensembl ENCODE 23 +52.3 52317 1.8 ELF3 SIN3A ARID4B DMAP1 ZNF48 RARA THAP11 SP5 KAT8 SSRP1 DCBLD1 ENSG00000226181 RNU6-253P NUS1 PIR41328
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DCBLD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCBLD1 Gene

Chromosome:
6
Start:
117,453,817 bp from pter
End:
117,569,858 bp from pter
Size:
116,042 bases
Orientation:
Plus strand

Genomic View for DCBLD1 Gene

Genes around DCBLD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCBLD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCBLD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCBLD1 Gene

Proteins for DCBLD1 Gene

  • Protein details for DCBLD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8Z6-DCBD1_HUMAN
    Recommended name:
    Discoidin, CUB and LCCL domain-containing protein 1
    Protein Accession:
    Q8N8Z6
    Secondary Accessions:
    • Q5H992
    • Q8IYK5
    • Q8N7L9
    • Q96NH2

    Protein attributes for DCBLD1 Gene

    Size:
    715 amino acids
    Molecular mass:
    77920 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC04663.1; Type=Frameshift; Positions=483; Evidence={ECO:0000305}; Sequence=BAC05258.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCBLD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCBLD1 Gene

Post-translational modifications for DCBLD1 Gene

  • Glycosylation at Asn 64, Asn 124, Asn 277, Asn 351, Asn 418, and Asn 455
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCBLD1 Gene

Domains & Families for DCBLD1 Gene

Suggested Antigen Peptide Sequences for DCBLD1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8Z6

UniProtKB/Swiss-Prot:

DCBD1_HUMAN :
  • Contains 1 CUB domain.
Domain:
  • Contains 1 CUB domain.
  • Contains 1 F5/8 type C domain.
  • Contains 1 LCCL domain.
genes like me logo Genes that share domains with DCBLD1: view

No data available for Gene Families for DCBLD1 Gene

Function for DCBLD1 Gene

Gene Ontology (GO) - Molecular Function for DCBLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070492 oligosaccharide binding IBA --
genes like me logo Genes that share ontologies with DCBLD1: view
genes like me logo Genes that share phenotypes with DCBLD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DCBLD1

miRNA for DCBLD1 Gene

miRTarBase miRNAs that target DCBLD1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCBLD1 Gene

Localization for DCBLD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCBLD1 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCBLD1 Gene COMPARTMENTS Subcellular localization image for DCBLD1 gene
Compartment Confidence
plasma membrane 3
cytosol 2
peroxisome 2
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for DCBLD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DCBLD1: view

Pathways & Interactions for DCBLD1 Gene

SuperPathways for DCBLD1 Gene

No Data Available

Interacting Proteins for DCBLD1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296955%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000300289%0d%0a
Selected Interacting proteins: Q8N8Z6-DCBD1_HUMAN ENSP00000296955 for DCBLD1 Gene via MINT STRING IID

Gene Ontology (GO) - Biological Process for DCBLD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCBLD1 Gene

Drugs & Compounds for DCBLD1 Gene

(2) Drugs for DCBLD1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2690
Irinotecan Approved, Investigational Pharma Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1080
genes like me logo Genes that share compounds with DCBLD1: view

Transcripts for DCBLD1 Gene

Unigene Clusters for DCBLD1 Gene

Discoidin, CUB and LCCL domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCBLD1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b
SP1: - - -
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for DCBLD1 Gene

GeneLoc Exon Structure for
DCBLD1
ECgene alternative splicing isoforms for
DCBLD1

Expression for DCBLD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCBLD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCBLD1 Gene

This gene is overexpressed in Liver (55.2) and Testis (13.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCBLD1 Gene



Protein tissue co-expression partners for DCBLD1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCBLD1 Gene:

DCBLD1

SOURCE GeneReport for Unigene cluster for DCBLD1 Gene:

Hs.658304
genes like me logo Genes that share expression patterns with DCBLD1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCBLD1 Gene

Orthologs for DCBLD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCBLD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCBLD1 34 35
  • 99.73 (n)
cow
(Bos Taurus)
Mammalia DCBLD1 34 35
  • 87.71 (n)
mouse
(Mus musculus)
Mammalia Dcbld1 34 16 35
  • 84.38 (n)
rat
(Rattus norvegicus)
Mammalia Dcbld1 34
  • 83.12 (n)
dog
(Canis familiaris)
Mammalia DCBLD1 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCBLD1 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCBLD1 35
  • 48 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCBLD1 34 35
  • 71.45 (n)
lizard
(Anolis carolinensis)
Reptilia DCBLD1 35
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcbld1 34
  • 62.85 (n)
zebrafish
(Danio rerio)
Actinopterygii dcbld1 35
  • 32 (a)
OneToOne
Species where no ortholog for DCBLD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCBLD1 Gene

ENSEMBL:
Gene Tree for DCBLD1 (if available)
TreeFam:
Gene Tree for DCBLD1 (if available)

Paralogs for DCBLD1 Gene

Paralogs for DCBLD1 Gene

(3) SIMAP similar genes for DCBLD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DCBLD1: view

Variants for DCBLD1 Gene

Sequence variations from dbSNP and Humsavar for DCBLD1 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1015130 -- 117,506,330(-) CAACA(A/G)CAGTG intron-variant
rs10457315 -- 117,550,385(+) CTTTT(C/T)TGGTG intron-variant
rs1045855 -- 117,561,046(-) CTGTC(C/T)GGTGT intron-variant, utr-variant-3-prime
rs10484301 -- 117,520,966(-) GCTAA(A/G)ATACA intron-variant
rs10563012 -- 117,529,281(+) CAAGA(-/TAT)TATAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCBLD1 Gene

Variant ID Type Subtype PubMed ID
esv2668460 CNV deletion 23128226
esv2732613 CNV deletion 23290073
esv3610496 CNV loss 21293372
esv3610497 CNV loss 21293372
nsv1133382 CNV tandem duplication 24896259
nsv477000 CNV novel sequence insertion 20440878
nsv507356 OTHER sequence alteration 20534489

Variation tolerance for DCBLD1 Gene

Residual Variation Intolerance Score: 18.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.82; 79.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCBLD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCBLD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCBLD1 Gene

Disorders for DCBLD1 Gene

Relevant External Links for DCBLD1

Genetic Association Database (GAD)
DCBLD1
Human Genome Epidemiology (HuGE) Navigator
DCBLD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCBLD1

No disorders were found for DCBLD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCBLD1 Gene

Publications for DCBLD1 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for DCBLD1 Gene

Sources for DCBLD1 Gene

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