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Aliases for DCANP1 Gene

Aliases for DCANP1 Gene

  • Dendritic Cell-Associated Nuclear Protein 2 3 4 5
  • Dendritic Cell Nuclear Protein-1 3 4
  • C5orf20 3 4
  • DCNP1 3 4
  • Chromosome 5 Open Reading Frame 20 2
  • Dendritic Cell Nuclear Protein 1 2

External Ids for DCANP1 Gene

Previous HGNC Symbols for DCANP1 Gene

  • C5orf20

Summaries for DCANP1 Gene

Entrez Gene Summary for DCANP1 Gene

  • This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCANP1 Gene

DCANP1 (Dendritic Cell-Associated Nuclear Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCANP1 Gene

  • Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCANP1 Gene

Genomics for DCANP1 Gene

Genomic Location for DCANP1 Gene

Chromosome:
5
Start:
135,444,214 bp from pter
End:
135,447,348 bp from pter
Size:
3,135 bases
Orientation:
Minus strand

Genomic View for DCANP1 Gene

Genes around DCANP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCANP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCANP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCANP1 Gene

No data available for Regulatory Elements for DCANP1 Gene

Proteins for DCANP1 Gene

  • Protein details for DCANP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF63-DCNP1_HUMAN
    Recommended name:
    Dendritic cell nuclear protein 1
    Protein Accession:
    Q8TF63

    Protein attributes for DCANP1 Gene

    Size:
    244 amino acids
    Molecular mass:
    26704 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCANP1 Gene

Proteomics data for DCANP1 Gene at MOPED

Post-translational modifications for DCANP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCANP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCANP1 Gene

Domains & Families for DCANP1 Gene

Protein Domains for DCANP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DCANP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCANP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DCANP1 Gene

Function for DCANP1 Gene

Molecular function for DCANP1 Gene

UniProtKB/Swiss-Prot Function:
Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCANP1 Gene

Localization for DCANP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCANP1 Gene

Nucleus. Cytoplasm. Note=Particularly on the periphery. Colocalizes with corticotropin-releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus. {ECO:0000269 PubMed:20693543}.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DCANP1 Gene

Pathways & Interactions for DCANP1 Gene

SuperPathways for DCANP1 Gene

No Data Available

Interacting Proteins for DCANP1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000421871%0d%0a9606.ENSP00000230321%0d%0a
Selected Interacting proteins: Q8TF63-DCNP1_HUMAN ENSP00000421871 for DCANP1 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DCANP1: view

No data available for Pathways by source and SIGNOR curated interactions for DCANP1 Gene

Drugs & Compounds for DCANP1 Gene

No Compound Related Data Available

Transcripts for DCANP1 Gene

mRNA/cDNA for DCANP1 Gene

(1) REFSEQ mRNAs :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DCANP1 Gene

No ASD Table

Relevant External Links for DCANP1 Gene

GeneLoc Exon Structure for
DCANP1
ECgene alternative splicing isoforms for
DCANP1

Expression for DCANP1 Gene

Protein differential expression in normal tissues from HIPED for DCANP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCANP1 Gene



mRNA Expression by UniProt/SwissProt for DCANP1 Gene

Q8TF63-DCNP1_HUMAN
Tissue specificity: Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells. Expressed in paraventricular nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly expressed in paraventricular nucleus of depressed patients compared to controls. Not expressed in monocytes and B-cells.

Protein tissue co-expression partners for DCANP1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DCANP1 Gene

Orthologs for DCANP1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DCANP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf20 35
  • 98.36 (n)
  • 96.31 (a)
Species with no ortholog for DCANP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCANP1 Gene

ENSEMBL:
Gene Tree for DCANP1 (if available)
TreeFam:
Gene Tree for DCANP1 (if available)

Paralogs for DCANP1 Gene

No data available for Paralogs for DCANP1 Gene

Variants for DCANP1 Gene

Sequence variations from dbSNP and Humsavar for DCANP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1031844 - 135,446,886(+) CAAGG(G/T)TTTGT reference, missense
rs12520809 - 135,446,820(+) AAGAT(C/G/T)GGAGT reference, missense
rs744247 -- 135,445,710(+) CCTTC(C/T)TCCAG utr-variant-3-prime
rs1031843 -- 135,446,868(+) TCGCA(C/G)GACCC reference, missense
rs874157 -- 135,443,772(-) GTGCT(G/T)GCAGC downstream-variant-500B

Variation tolerance for DCANP1 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCANP1 Gene

HapMap Linkage Disequilibrium report
DCANP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCANP1 Gene

Disorders for DCANP1 Gene

Relevant External Links for DCANP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCANP1

No disorders were found for DCANP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCANP1 Gene

Publications for DCANP1 Gene

  1. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. (PMID: 11798177) Masuda M. … Nishimura Y. (Biochem. Biophys. Res. Commun. 2002) 2 3 4 23 67
  2. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. (PMID: 20693543) Zhou T. … Swaab D.F. (Brain 2010) 2 3
  3. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E. … Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Lack of association between dendritic cell nuclear protein-1 gene and major depressive disorder in the Han Chinese population. (PMID: 23619526) Li H. … Xu Z.Q. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2013) 3

Products for DCANP1 Gene

Sources for DCANP1 Gene

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