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Aliases for DCANP1 Gene

Aliases for DCANP1 Gene

  • Dendritic Cell Associated Nuclear Protein 2 3 5
  • Dendritic Cell Nuclear Protein 1 2 3
  • C5orf20 3 4
  • DCNP1 3 4
  • Dendritic Cell-Associated Nuclear Protein 4
  • Chromosome 5 Open Reading Frame 20 2
  • Dendritic Cell Nuclear Protein-1 4

External Ids for DCANP1 Gene

Previous HGNC Symbols for DCANP1 Gene

  • C5orf20

Summaries for DCANP1 Gene

Entrez Gene Summary for DCANP1 Gene

  • This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]

GeneCards Summary for DCANP1 Gene

DCANP1 (Dendritic Cell Associated Nuclear Protein) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCANP1 Gene

  • Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.

Additional gene information for DCANP1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCANP1 Gene

Genomics for DCANP1 Gene

Regulatory Elements for DCANP1 Gene

Enhancers for DCANP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H135353 0.8 ENCODE dbSUPER 11.8 +91.7 91747 4 NFIC JUND REST RCOR1 NR2F2 ENSG00000270021 H2AFY DCANP1 PIR34891 GC05M135339
GH05H135357 0.6 dbSUPER 11.8 +87.2 87190 4 ZFHX2 PRDM6 ZNF585B ZIC2 PRDM1 NR2F2 EGR2 ENSG00000270021 H2AFY DCANP1 TXNDC15 JADE2 PIR34891 GC05M135339
GH05H135132 1.7 FANTOM5 ENCODE dbSUPER 2.4 +312.6 312567 3 HDGF PKNOX1 ARNT ARID4B DMAP1 YY1 ZNF766 CBX5 MXD4 ZC3H11A DCANP1 PITX1 LOC105379188 C5orf66-AS2
GH05H135433 1.5 VISTA Ensembl ENCODE 0.4 +12.4 12423 3 BCOR ELF3 TBP TFAP4 ARID4B ZMYM3 ZBTB40 POLR2A ADNP SMARCA5 ENSG00000249639 H2AFY NEUROG1 ENSG00000270021 DCANP1
GH05H135436 1.1 Ensembl ENCODE 0.4 +8.9 8943 3 PKNOX1 NFIB SIN3A ZNF766 RUNX3 IKZF2 ZBTB11 HDAC8 ZNF592 NFIC TXNDC15 H2AFY ENSG00000249639 JADE2 DCANP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCANP1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCANP1 Gene

Chromosome:
5
Start:
135,444,214 bp from pter
End:
135,447,348 bp from pter
Size:
3,135 bases
Orientation:
Minus strand

Genomic View for DCANP1 Gene

Genes around DCANP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCANP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCANP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCANP1 Gene

Proteins for DCANP1 Gene

  • Protein details for DCANP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TF63-DCNP1_HUMAN
    Recommended name:
    Dendritic cell nuclear protein 1
    Protein Accession:
    Q8TF63

    Protein attributes for DCANP1 Gene

    Size:
    244 amino acids
    Molecular mass:
    26704 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCANP1 Gene

Post-translational modifications for DCANP1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCANP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCANP1 Gene

Domains & Families for DCANP1 Gene

Gene Families for DCANP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DCANP1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for DCANP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCANP1: view

No data available for UniProtKB/Swiss-Prot for DCANP1 Gene

Function for DCANP1 Gene

Molecular function for DCANP1 Gene

UniProtKB/Swiss-Prot Function:
Binds with and transactivates the corticotropin-releasing hormone (CRH) promoter.

Gene Ontology (GO) - Molecular Function for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with DCANP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCANP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCANP1 Gene

Localization for DCANP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCANP1 Gene

Nucleus. Cytoplasm. Note=Particularly on the periphery. Colocalizes with corticotropin-releasing hormone (CRH) in parvocellular neurons in the paraventricular nucleus. {ECO:0000269 PubMed:20693543}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCANP1 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DCANP1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for DCANP1 Gene

Pathways & Interactions for DCANP1 Gene

SuperPathways for DCANP1 Gene

No Data Available

Interacting Proteins for DCANP1 Gene

Selected Interacting proteins: Q8TF63-DCNP1_HUMAN for DCANP1 Gene via IID UniProtKB

Symbol External ID(s) Details
MDFI

Gene Ontology (GO) - Biological Process for DCANP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007356 thorax and anterior abdomen determination IGI 23419067
GO:0021559 trigeminal nerve development IGI 23419067
GO:0021650 vestibulocochlear nerve formation IGI 23419067
genes like me logo Genes that share ontologies with DCANP1: view

No data available for Pathways by source and SIGNOR curated interactions for DCANP1 Gene

Drugs & Compounds for DCANP1 Gene

No Compound Related Data Available

Transcripts for DCANP1 Gene

mRNA/cDNA for DCANP1 Gene

(1) REFSEQ mRNAs :
(19) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for DCANP1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for DCANP1 Gene

No ASD Table

Relevant External Links for DCANP1 Gene

GeneLoc Exon Structure for
DCANP1
ECgene alternative splicing isoforms for
DCANP1

Expression for DCANP1 Gene

Protein differential expression in normal tissues from HIPED for DCANP1 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DCANP1 Gene



Protein tissue co-expression partners for DCANP1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCANP1 Gene:

DCANP1

mRNA Expression by UniProt/SwissProt for DCANP1 Gene:

Q8TF63-DCNP1_HUMAN
Tissue specificity: Expressed in neurons of the paraventricular nucleus, thalamus and occipital cortex and in glial cells (at protein level). Predominantly expressed in dendritic cells. Detected in brain and skeletal muscle. Highly expressed in mature dendritic cells and at a lower level in immature dendritic cells. Expressed in paraventricular nucleus, supraoptic nucleus and nucleus basalis of Meynert. Strongly expressed in paraventricular nucleus of depressed patients compared to controls. Not expressed in monocytes and B-cells.

Evidence on tissue expression from TISSUES for DCANP1 Gene

  • Lung(4)

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCANP1 Gene

Orthologs for DCANP1 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DCANP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C5H5orf20 33
  • 98.36 (n)
Species where no ortholog for DCANP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCANP1 Gene

ENSEMBL:
Gene Tree for DCANP1 (if available)
TreeFam:
Gene Tree for DCANP1 (if available)

Paralogs for DCANP1 Gene

No data available for Paralogs for DCANP1 Gene

Variants for DCANP1 Gene

Sequence variations from dbSNP and Humsavar for DCANP1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000476115 -- 135,447,971(+) GGTCC(C/G)AAGGG upstream-variant-2KB
rs1000516626 -- 135,446,158(+) GTGAA(-/C)TTTCC utr-variant-3-prime
rs1001559869 -- 135,445,565(+) CCCCC(C/T)GTCTG utr-variant-3-prime
rs1001893830 -- 135,444,594(+) GCCCA(C/G)TGCAG utr-variant-3-prime
rs1002367668 -- 135,449,199(+) TTGTT(C/T)GGTGT upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DCANP1 Gene

Variant ID Type Subtype PubMed ID
esv2657420 CNV deletion 23128226

Variation tolerance for DCANP1 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.30; 53.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCANP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCANP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCANP1 Gene

Disorders for DCANP1 Gene

Relevant External Links for DCANP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCANP1

No disorders were found for DCANP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCANP1 Gene

Publications for DCANP1 Gene

  1. Identification and immunocytochemical analysis of DCNP1, a dendritic cell-associated nuclear protein. (PMID: 11798177) Masuda M … Nishimura Y (Biochemical and biophysical research communications 2002) 2 3 4 22 60
  2. Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression. (PMID: 20693543) Zhou T … Swaab DF (Brain : a journal of neurology 2010) 2 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E … Simpson AJ (Proceedings of the National Academy of Sciences of the United States of America 2000) 2 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for DCANP1 Gene

Sources for DCANP1 Gene

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