DCAKD Gene
protein-coding GIFtS: 50
GCID: GC17M043100
|
|
dephospho-CoA kinase domain containing
| |
Aliases
for DCAKD gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dephospho-CoA Kinase Domain Containing1 2 | | FLJ229551 | | Dephospho-CoA Kinase Domain-Containing Protein2 | | EC 2.7.1.248 |
Export aliases for DCAKD gene to outside databasesPrevious GC identifers: GC17M040457 GC17M038864 |
Summaries
for DCAKD gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DCAKD gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DCAKD gene promoter:
c-Fos AP-1 MAZR Cart-1 AP-4 IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCAKD
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAKD |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31DCAKD Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M043100: view genomic region
(about GC identifiers)
Start:
|
43,100,706 bp from pter |
End:
|
43,138,473 bp from pter |
Size:
|
37,768 bases |
Orientation:
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minus strand |
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Proteins
for DCAKD gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCAKD_HUMAN, Q8WVC6 (See
protein sequence)Recommended Name: Dephospho-CoA kinase domain-containing protein Size: 231 amino acids; 26550 Da
Secondary accessions: A8K3Z0 D3DX60 D3DX62 Q9BR71 Q9H5W1Alternative splicing: 2 isoforms: Q8WVC6-1 Q8WVC6-2 Explore the universe of human proteins at neXtProt for DCAKD: NX_Q8WVC6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVC6
2 DME Specific Peptides for DCAKD (Q8WVC6)
DCAKD Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001122103.1 NP_079095.3
ENSEMBL proteins: ENSP00000413483 ENSP00000341504 ENSP00000467913 ENSP00000468809 ENSP00000308515
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
DCAKD for ontologies About GeneDecksing
DCAKD Antibody Products:
Assay Products for DCAKD: |
Protein
Domains /
Families
for DCAKD gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCAKD for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WVC6ProtoNet protein and cluster: Q8WVC6 1 Blocks protein family: IPB001977 Dephospho-CoA kinase
UniProtKB/Swiss-Prot: DCAKD_HUMAN, Q8WVC6Similarity: Belongs to the CoaE familySimilarity: Contains 1 DPCK (dephospho-CoA kinase) domain |
Function
for DCAKD gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 2.7.1.242
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAKD (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAKD (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): DCAKD (NM_001128631) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAKD | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAKD |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAKD |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004140 | dephospho-CoA kinase activity |
IEA | -- | | GO:0005524 | ATP binding |
IEA | -- |
DCAKD for ontologies About GeneDecksing
|
Pathways & Interactions
for DCAKD gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Integrated Breast Cancer Pathway | |
1  BioSystems Pathway for DCAKD
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCAKD
STRING Interaction
Network Preview (showing 5 interactants - click image to see 6)
5/32 Interacting proteins for DCAKD (Q8WVC63 ENSP000003415044) via UniProtKB, MINT, STRING, and/or I2D (see all 32)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0015937 | coenzyme A biosynthetic process |
IEA | -- |
DCAKD for ontologies About GeneDecksing
|
Drugs & Compounds
for DCAKD gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCAKD
Search CenterWatch for drugs/clinical trials and news about DCAKD
|
Transcripts
for DCAKD gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCAKD gene (2 alternative transcripts): NM_001128631.1 NM_024819.4 Unigene Cluster for DCAKD: Dephospho-CoA kinase domain containing Hs.463148 [show with all ESTs]Unigene Representative Sequence: NM_0248197 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000452796(uc002ihx.2 uc010daa.1) ENST00000342350(uc010dab.1)
ENST00000588499 ENST00000593094 ENST00000592902 ENST00000588295 ENST00000310604(uc002ihy.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAKD (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAKD (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): DCAKD (NM_001128631) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAKD | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAKD |
Additional cDNA sequence: AK026608.1 AK290755.1 BC006472.1 BC006546.2 BC018132.2 BC033299.1 11 DOTS entries: DT.446140 DT.95102987 DT.92423080 DT.100782259 DT.97805778 DT.100825424 DT.120953438 DT.40275492 DT.92423083 DT.91688209 DT.91986485 24/93 AceView cDNA sequences (see all 93): BX333265 BM141882 BC018132 BM128029 BX342453 BI093355 BX109987 BU168354 BC033299 CK819136 BM142189 W65474 AK026608 BM127765 BF347569 CD388079 BE907883 BM547488 BM784413 CB215317 BF796387 BC006546 BX352722 BM047820
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DCAKD (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|
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| SP1: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for DCAKD
|
Expression
for DCAKD gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCAKD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGCCCAGGAA
About this image
See DCAKD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCAKD
SOURCE GeneReport for Unigene cluster: Hs.463148
SABiosciences Custom PCR Arrays for DCAKD
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAKD
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCAKD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAKD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAKD | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAKD |
Orthologs
for DCAKD gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for DCAKD gene from 11/33 species (see all 33) About this table
ENSEMBL Gene Tree for DCAKD (if available)
TreeFam Gene Tree for DCAKD (if available) |
Paralogs
for DCAKD gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DCAKD gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCAKD (43100706 - 43138473 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DCAKD
1 CNV: 102466
1 Indel: 25853 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAKD |
|
Disorders
/ Diseases
for DCAKD gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DCAKD for disorders About GeneDecksing
3  diseases for DCAKD: About MalaCardspneumonia tuberculosis mycobacterium tuberculosis
Human Genome Epidemiology (HuGE) Navigator: DCAKD (2 documents)
Export disorders for DCAKD gene to outside databases
|
Publications
for DCAKD gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCAKD gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with DCAKD) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Large-scale analysis of the human ubiquitin-related p roteome. (PubMed id 16196087)1 Matsumoto M....Nakayama K.I. (2005)
|
External Searches for DCAKD gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCAKD gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCAKD gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCAKD gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCAKD | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCAKD gene:
Search GeneIP for patents involving DCAKD
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCAKD gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DCAKD | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCAKD | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAKD | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DCAKD | | OriGene 3'-UTR Clone for DCAKD | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAKD | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAKD | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DCAKD | | OriGene Custom Protein Services for DCAKD | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCAKD | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAKD | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAKD | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCAKD | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAKD | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAKD |
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 |  |  |  | |
| | | | Search Tocris compounds for DCAKD |
| |  |  |  |  | | | | |
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 | | | DCAKD Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAKD |
|  |  |  | | | | Search ThermoFisher Antibodies for DCAKD |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAKD |
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