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DCAKD Gene

protein-coding GIFtS: 51

GC17M040457

dephospho-CoA kinase domain containing
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
FLJ22955 ^¹, ²

Descriptions
dephospho-CoA kinase domain containing ^²

External Ids
HGNC: 26238¹
Entrez Gene: 79877²
UniProtKB: Q8WVC6³
Ensembl: ENSG00000172992⁷

Search outside databases for aliases for DCAKD gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DCAKD gene

Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31

DCAKD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M040457: (about GC identifiers)

Start:	40,456,238 bp from pter
End:	40,493,912 bp from pter
Size:	37,675 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010783.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DCAKD_HUMAN, Q8WVC6 (See protein sequence)

Recommended Name: Dephospho-CoA kinase domain-containing protein

Size: 231 amino acids; 26550 Da

Secondary accessions: A8K3Z0 Q9BR71 Q9H5W1

Alternative splicing: 2 isoforms: Q8WVC6-1 Q8WVC6-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001122103.1 NP_079095.3

ENSEMBL proteins:

ENSP00000308515 ENSP00000341504

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DCAKD)
	Human Recombinant Proteins from Abnova (DCAKD)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for DCAKD:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DCAKD
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DCAKD), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DCAKD)
	Novus Biologicals Antibodies for DCAKD

Assays for DCAKD:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q8WVC6

ProtoNet protein and cluster: Q8WVC6

1 Blocks protein family: IPB001977 Dephospho-CoA kinase

UniProtKB/Swiss-Prot: DCAKD_HUMAN, Q8WVC6

Similarity: Belongs to the coaE family

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DCAKD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DCAKD)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024819

Applied Biosystems Silencer® siRNAs for DCAKD

Sigma-Aldrich siRNA for DCAKD

Sigma-Aldrich shRNA Panels and shRNA for DCAKD

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001128631
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001128631
untagged cDNA clones in CMV expression vector (see all 2): NM_001128631

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_024819

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005524	ATP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for DCAKD (ENSP00000341504³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
--	ENSP00000353103³	STRING (score=.73)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DCAKD

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DCAKD)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DCAKD)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_024819

Sigma-Aldrich siRNA for DCAKD

Sigma-Aldrich shRNA Panels and shRNA for DCAKD

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001128631 NM_024819

REFSEQ mRNAs for DCAKD gene (2 alternative transcripts):

NM_001128631.1 NM_024819.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001128631 NM_024819

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001128631
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001128631
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001128631

Additional cDNA sequence:

AK026608.1 AK290755.1 BC006472.1 BC006546.2 BC018132.2 BC033299.1

12 DOTS entries:

DT.446140 DT.95102987 DT.92423080 DT.100782259 DT.97805778 DT.100825424 DT.120953438 DT.40261782

DT.40275492 DT.91688209 DT.92423083 DT.91986485

24/93 AceView cDNA sequences (see all 93 ):

BM141882 BX333265 BM128029 BX342453 BU168354 BI093355 BM127765 AK026608

BC033299 BM142189 W65474 CK819136 BX109987 BC018132 BF347569 W65425

BG036192 BM471581 BC006472 BQ896393 CD388079 AW247053 BQ771961 CB215317

highest scoring ESTs for DCAKD:

AW247053 BC006472 BC006546 BF115235 BM127765 BM127947 BM128029 BM128272 BM141882 BM142189

Unigene Cluster for DCAKD:

Dephospho-CoA kinase domain containing

Hs.463148 [show with all ESTs]

Unigene Representative Sequence: NM_024819

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DCAKD (see all 6 )

ExUns:	1a	·	1b	^	2a	·	2b	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	·	8c
SP1:									-		-						-
SP2:											-						-
SP3:					-		-		-		-						-
SP4:									-		-
SP5:																	-

About this scheme

ECgene alternative splicing isoforms for DCAKD

2 Ensembl transcripts including schematic representations:

ENST00000310604 ENST00000342350

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DCAKD expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DCAKD

¹ / ² / ³

8 probe-sets matching DCAKD gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
85330_at²^{, 3}	U95-D	1	0.94	1.00	0.67	0.87	AI939621	0.60	1.00	0.82	1
62943_at²^{, 3}	U95-C	1	0.31	1.00	0.92	1.14	W87582	0.20	1.00	0.72	1
221224_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024819	0.60	1.00	0.82	1
224522_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC006472	0.80	1.00	0.91	1
221225_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_024819	0.60	1.00	0.82	1
221224_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224522_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221225_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DCAKD for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AGCCCAGGAA

SOURCE GeneReport for Unigene cluster: Hs.463148

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DCAKD gene from 5/20 species (see all 20 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DCAKD¹	--	dephospho-CoA kinase domain containing	87.46(n) 90.21(a)	490930 XM_548053.2 XP_548053.2
chimpanzee (Pan troglodytes)	DCAKD¹	--	dephospho-CoA kinase domain containing	98.85(n) 98.27(a)	468392 XM_001144011.1 XP_001144011.1
cow (Bos taurus)	DCAKD¹	--	dephospho-CoA kinase domain containing	88.65(n) 90.83(a)	508778 XM_001255369.1 XP_001255370.1
rat (Rattus norvegicus)	Dcakd¹	--	dephospho-CoA kinase domain containing	87.19(n) 90.83(a)	360639 NM_001007724.1 NP_001007725.1
mouse (Mus musculus)	Dcakd^{1, 5}	11⁵	dephospho-CoA kinase domain containing^{1, 5}	86.17(n)¹ 91.27(a)¹	68087¹ NM_026551.3¹ NP_080827.2¹ AA003954⁵ AI849483⁵ (see all 24)

About this table Species with no ortholog for DCAKD

ENSEMBL Gene Tree for DCAKD

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DCAKD gene

COASY²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/199 NCBI SNPs in DCAKD are shown (see all 199 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 45)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs7225329^1,2	A,C,F,H	40456908(+)	`GGCCAT/CAATGG`	2	--	ut3¹ ese³		5		MN EU EA WA	596
--	rs12568^1,2	C,F,H	40456357(-)	`CCTACT/GAGACT`	2	--	ut3¹ ese³		6		MN EU EA WA	784
	rs7225735^1,2	A,C,F	40456807(+)	`AGTATA/CAAAAA`	2	--	ut3¹		1		MN	184
	rs7220212^1,2	A,C	40456092(+)	`TCCCAC/GAAAGG`	1	--	ng5¹		0	--	--	--	--
--	rs9899209^1,2	C	40457112(+)	`CTTGAC/TCTCAA`	2	--	ut3¹		0	--	--	--	--
	rs11871625^1,2	C	40455855(+)	`CTAGAC/TTCAGC`	1	--	ng5¹		0	--	--	--	--
	rs9900173^1,2	A,C,F,H	40467214(+)	`TCGCCG/ATTCTC`	2	N/N	syn¹		8		EU EA WA	838
	rs708381^1,2	A,C,F,H,O	40458114(-)	`AGGAGG/ATATTT`	1	--	int¹		12		NA MN EU EA WA	2610
	rs9915259^1,2	A,C,F,H	40473703(+)	`TTCTAT/CTGTGC`	1	--	int¹		8		EU EA WA	838
--	rs4793179^1,2	A,C,F,H	40476603(+)	`cttgtT/Ccgaat`	1	--	int¹		3		EU EA	300

About this table

HapMap Linkage Disequilibrium images for DCAKD (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

3 PubMed articles for DCAKD gene:

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 79877	HGNC: 26238	AceView: FLJ22955	Ensembl:ENSG00000172992	euGenes: HUgn79877
ECgene: DCAKD	H-InvDB: DCAKD

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for DCAKD
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DCAKD:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DCAKD-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DCAKD		Antibodies for DCAKD
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DCAKD		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (DCAKD)
	Antibodies (DCAKD)
	Chimera RNAi (DCAKD)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Antibodies for DCAKD

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DCAKD Gene

protein-coding GIFtS: 51

Aliases &
Descriptions
for DCAKD

Summaries
for DCAKD

Genomic Location
for DCAKD

Proteins
for DCAKD

Protein Domains/
Families
for DCAKD

Gene Function
for DCAKD

Pathways & Interactions
for DCAKD

Drugs & Compounds
for DCAKD

Transcripts
for DCAKD

Expression
for DCAKD

Orthologs
for DCAKD

Paralogs
for DCAKD

SNPs/Variants
for DCAKD

Disorders & Mutations
for DCAKD

Medical News
for DCAKD

Publications
for DCAKD

Search for DCAKD

Genome Databases showing DCAKD

Other Databases showing DCAKD

Specialized Databases showing DCAKD

Licensable Technologies
for DCAKD

Services
for DCAKD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DCAKD Gene

protein-coding GIFtS: 51

Aliases & Descriptionsfor DCAKD

Summariesfor DCAKD

Genomic Locationfor DCAKD

Proteinsfor DCAKD

Protein Domains/Familiesfor DCAKD

Gene Functionfor DCAKD

Pathways & Interactionsfor DCAKD

Drugs & Compoundsfor DCAKD

Transcriptsfor DCAKD

Expression for DCAKD

Orthologsfor DCAKD

Paralogsfor DCAKD

SNPs/Variantsfor DCAKD

Disorders & Mutationsfor DCAKD

Medical Newsfor DCAKD

Publicationsfor DCAKD

Search for DCAKD

Genome Databases showing DCAKD

Other Databases showing DCAKD

Specialized Databases showing DCAKD

Licensable Technologiesfor DCAKD

Servicesfor DCAKD

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DCAKD

Summaries
for DCAKD

Genomic Location
for DCAKD

Proteins
for DCAKD

Protein Domains/
Families
for DCAKD

Gene Function
for DCAKD

Pathways & Interactions
for DCAKD

Drugs & Compounds
for DCAKD

Transcripts
for DCAKD

Expression
for DCAKD

Orthologs
for DCAKD

Paralogs
for DCAKD

SNPs/Variants
for DCAKD

Disorders & Mutations
for DCAKD

Medical News
for DCAKD

Publications
for DCAKD

Licensable Technologies
for DCAKD

Services
for DCAKD