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Aliases for DCAKD Gene

Aliases for DCAKD Gene

  • Dephospho-CoA Kinase Domain Containing 2 3 5
  • EC 58

External Ids for DCAKD Gene

Previous GeneCards Identifiers for DCAKD Gene

  • GC17M040457
  • GC17M043100
  • GC17M038864

Summaries for DCAKD Gene

GeneCards Summary for DCAKD Gene

DCAKD (Dephospho-CoA Kinase Domain Containing) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include dephospho-CoA kinase activity.

Additional gene information for DCAKD Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAKD Gene

Genomics for DCAKD Gene

Regulatory Elements for DCAKD Gene

Enhancers for DCAKD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H045089 1.8 FANTOM5 Ensembl ENCODE dbSUPER 34.9 -31.1 -31065 4.6 TBP FOXA2 ZSCAN4 ARID4B SIN3A RAD21 RARA YY1 ZNF121 FOS DCAKD PLCD3 GFAP NMT1 ACBD4 HEXIM1 HIGD1B ADAM11 ENSG00000200888 MIR6784
GH17H045020 1.5 Ensembl ENCODE dbSUPER 27.3 +39.7 39717 2.5 ATF1 ZFP64 ARID4B SIN3A DMAP1 ZNF143 ZNF207 ATF7 PAF1 SP5 DCAKD NMT1 C1QL1 GFAP FAM187A EFTUD2 CCDC103 KIF18B HEXIM2 ENSG00000224505
GH17H045049 1.3 ENCODE dbSUPER 31 +9.8 9787 3 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3 SP5 DCAKD ENSG00000262372 UBTF ASB16-AS1 SLC25A39 NMT1 GC17M045043
GH17H045143 1.8 FANTOM5 ENCODE dbSUPER 21.9 -86.8 -86806 9.6 MLX FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 SP3 NFYC ENSG00000262372 UBTF ASB16-AS1 TMUB2 ENSG00000224505 LINC02210 HEXIM1 EFTUD2 MAP3K14-AS1 ENSG00000260793
GH17H045042 1.5 Ensembl ENCODE dbSUPER 25.9 +15.0 15049 6.8 HDGF PKNOX1 ZNF493 ZFP64 SIN3A ZNF121 FOS ZNF202 ZC3H11A REST UBTF ENSG00000262372 ASB16-AS1 TMUB2 DCAKD ENSG00000224505 ENSG00000266918 GPATCH8 LINC02210 PLCD3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCAKD on UCSC Golden Path with GeneCards custom track

Promoters for DCAKD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for DCAKD Gene

Genomic Locations for DCAKD Gene
37,804 bases
Minus strand

Genomic View for DCAKD Gene

Genes around DCAKD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAKD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAKD Gene

Proteins for DCAKD Gene

  • Protein details for DCAKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dephospho-CoA kinase domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A8K3Z0
    • D3DX60
    • D3DX62
    • Q9BR71
    • Q9H5W1

    Protein attributes for DCAKD Gene

    231 amino acids
    Molecular mass:
    26550 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCAKD Gene


neXtProt entry for DCAKD Gene

Selected DME Specific Peptides for DCAKD Gene


Post-translational modifications for DCAKD Gene

  • Ubiquitination at posLast=6767, posLast=168168, and isoforms=186
  • Modification sites at PhosphoSitePlus

Domains & Families for DCAKD Gene

Gene Families for DCAKD Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for DCAKD Gene

Suggested Antigen Peptide Sequences for DCAKD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CoaE family.
  • Belongs to the CoaE family.
genes like me logo Genes that share domains with DCAKD: view

Function for DCAKD Gene

Enzyme Numbers (IUBMB) for DCAKD Gene

Phenotypes From GWAS Catalog for DCAKD Gene

Gene Ontology (GO) - Molecular Function for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004140 dephospho-CoA kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DCAKD: view
genes like me logo Genes that share phenotypes with DCAKD: view

Animal Model Products

Clone Products

  • Addgene plasmids for DCAKD

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAKD Gene

Localization for DCAKD Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAKD gene
Compartment Confidence
mitochondrion 3
cytosol 3
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DCAKD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAKD Gene

Pathways & Interactions for DCAKD Gene

genes like me logo Genes that share pathways with DCAKD: view

Pathways by source for DCAKD Gene

1 BioSystems pathway for DCAKD Gene

Gene Ontology (GO) - Biological Process for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015937 coenzyme A biosynthetic process IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DCAKD: view

No data available for SIGNOR curated interactions for DCAKD Gene

Drugs & Compounds for DCAKD Gene

No Compound Related Data Available

Transcripts for DCAKD Gene

Unigene Clusters for DCAKD Gene

Dephospho-CoA kinase domain containing:
Representative Sequences:

Clone Products

  • Addgene plasmids for DCAKD

Alternative Splicing Database (ASD) splice patterns (SP) for DCAKD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for DCAKD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAKD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAKD Gene

Protein differential expression in normal tissues from HIPED for DCAKD Gene

This gene is overexpressed in Nasal epithelium (27.3) and Bone (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCAKD Gene

Protein tissue co-expression partners for DCAKD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAKD Gene:


SOURCE GeneReport for Unigene cluster for DCAKD Gene:


Evidence on tissue expression from TISSUES for DCAKD Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Pancreas(4.1)
genes like me logo Genes that share expression patterns with DCAKD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAKD Gene

Orthologs for DCAKD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAKD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAKD 33 34
  • 99.13 (n)
(Bos Taurus)
Mammalia DCAKD 33 34
  • 89.55 (n)
(Canis familiaris)
Mammalia DCAKD 33 34
  • 87.92 (n)
(Rattus norvegicus)
Mammalia Dcakd 33
  • 87 (n)
(Mus musculus)
Mammalia Dcakd 33 16 34
  • 86.09 (n)
(Monodelphis domestica)
Mammalia DCAKD 34
  • 65 (a)
(Gallus gallus)
Aves DCAKD 33 34
  • 67.13 (n)
(Anolis carolinensis)
Reptilia DCAKD 34
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcakd 33
  • 60.55 (n)
Str.7183 33
(Danio rerio)
Actinopterygii dcakd 33 34
  • 61.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dpck 33 34
  • 55.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004425 33
  • 51.16 (n)
(Caenorhabditis elegans)
Secernentea T05G5.5 33 34
  • 48.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL110C 33
  • 53.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18711g 33
  • 46.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB5 33 34 36
  • 46.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATCOAE 33
  • 46.36 (n)
(Oryza sativa)
Liliopsida Os01g0360600 33
  • 50.09 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00369 33
  • 53.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC14G10.01 33
  • 48.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
Species where no ortholog for DCAKD was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAKD Gene

Gene Tree for DCAKD (if available)
Gene Tree for DCAKD (if available)

Paralogs for DCAKD Gene

(1) SIMAP similar genes for DCAKD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAKD: view

No data available for Paralogs for DCAKD Gene

Variants for DCAKD Gene

Sequence variations from dbSNP and Humsavar for DCAKD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000027557 -- 45,054,204(+) TACAT(G/T)TACAT intron-variant
rs1000177332 -- 45,057,795(+) CACCT(-/GAG)GTCAG intron-variant
rs1000195666 -- 45,049,187(+) AATCC(C/G)AGCAC intron-variant
rs1000242322 -- 45,056,525(+) TTGGA(G/T)TGCAA intron-variant
rs1000281128 -- 45,037,004(+) GCTTG(A/G)ATGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAKD Gene

Variant ID Type Subtype PubMed ID
nsv953902 CNV deletion 24416366
nsv833457 CNV loss 17160897
nsv527788 CNV loss 19592680
nsv1146669 OTHER inversion 26484159
nsv1144803 CNV deletion 24896259
nsv1072739 CNV deletion 25765185
esv3640657 CNV loss 21293372
esv2674469 CNV deletion 23128226
esv2438788 CNV deletion 19546169
esv1217416 CNV deletion 17803354

Variation tolerance for DCAKD Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAKD Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAKD Gene

Disorders for DCAKD Gene

Relevant External Links for DCAKD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCAKD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAKD Gene

Publications for DCAKD Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 45 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60

Products for DCAKD Gene

  • Addgene plasmids for DCAKD

Sources for DCAKD Gene

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