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Aliases for DCAKD Gene

Aliases for DCAKD Gene

  • Dephospho-CoA Kinase Domain Containing 2 3
  • EC 2.7.1.24 63

External Ids for DCAKD Gene

Previous GeneCards Identifiers for DCAKD Gene

  • GC17M040457
  • GC17M043100
  • GC17M038864

Summaries for DCAKD Gene

GeneCards Summary for DCAKD Gene

DCAKD (Dephospho-CoA Kinase Domain Containing) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include dephospho-CoA kinase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAKD Gene

Genomics for DCAKD Gene

Regulatory Elements for DCAKD Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAKD Gene

Start:
45,023,338 bp from pter
End:
45,061,130 bp from pter
Size:
37,793 bases
Orientation:
Minus strand

Genomic View for DCAKD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAKD Gene

Proteins for DCAKD Gene

  • Protein details for DCAKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVC6-DCAKD_HUMAN
    Recommended name:
    Dephospho-CoA kinase domain-containing protein
    Protein Accession:
    Q8WVC6
    Secondary Accessions:
    • A8K3Z0
    • D3DX60
    • D3DX62
    • Q9BR71
    • Q9H5W1

    Protein attributes for DCAKD Gene

    Size:
    231 amino acids
    Molecular mass:
    26550 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCAKD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAKD Gene

Proteomics data for DCAKD Gene at MOPED

Selected DME Specific Peptides for DCAKD Gene

Post-translational modifications for DCAKD Gene

  • Ubiquitination at Lys67, Lys168, and Lys186
  • Modification sites at PhosphoSitePlus

Domains for DCAKD Gene

Protein Domains for DCAKD Gene

Suggested Antigen Peptide Sequences for DCAKD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVC6

UniProtKB/Swiss-Prot:

DCAKD_HUMAN :
  • Q8WVC6
Domain:
  • Contains 1 DPCK (dephospho-CoA kinase) domain.
Family:
  • Belongs to the CoaE family.
genes like me logo Genes that share domains with DCAKD: view

No data available for Gene Families for DCAKD Gene

Function for DCAKD Gene

Enzyme Numbers (IUBMB) for DCAKD Gene

Gene Ontology (GO) - Molecular Function for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004140 dephospho-CoA kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DCAKD: view

Animal Model Products

CRISPR Products

miRNA for DCAKD Gene

miRTarBase miRNAs that target DCAKD

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAKD Gene

Localization for DCAKD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAKD Gene COMPARTMENTS Subcellular localization image for DCAKD gene
Compartment Confidence
cytosol 3
mitochondrion 2
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DCAKD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAKD Gene

Pathways for DCAKD Gene

genes like me logo Genes that share pathways with DCAKD: view

Pathways by source for DCAKD Gene

1 BioSystems pathway for DCAKD Gene

Interacting Proteins for DCAKD Gene

Gene Ontology (GO) - Biological Process for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015937 coenzyme A biosynthetic process IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DCAKD: view

Transcripts for DCAKD Gene

Unigene Clusters for DCAKD Gene

Dephospho-CoA kinase domain containing:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAKD

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAKD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for DCAKD Gene

GeneLoc Exon Structure for
DCAKD
ECgene alternative splicing isoforms for
DCAKD

Expression for DCAKD Gene

mRNA expression in normal human tissues for DCAKD Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAKD Gene

SOURCE GeneReport for Unigene cluster for DCAKD Gene Hs.463148

genes like me logo Genes that share expressions with DCAKD: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAKD Gene

Orthologs for DCAKD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAKD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAKD 35
  • 99.13 (n)
  • 98.7 (a)
DCAKD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCAKD 35
  • 89.55 (n)
  • 94.03 (a)
DCAKD 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAKD 35
  • 87.92 (n)
  • 92.2 (a)
DCAKD 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcakd 35
  • 86.09 (n)
  • 91.74 (a)
Dcakd 16
Dcakd 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAKD 36
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcakd 35
  • 87 (n)
  • 91.28 (a)
chicken
(Gallus gallus)
Aves DCAKD 35
  • 67.13 (n)
  • 62.67 (a)
DCAKD 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAKD 36
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcakd 35
  • 60.55 (n)
  • 58.72 (a)
Str.7183 35
zebrafish
(Danio rerio)
Actinopterygii dcakd 35
  • 61.42 (n)
  • 56.94 (a)
dcakd 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004425 35
  • 51.16 (n)
  • 43.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dpck 35
  • 55.19 (n)
  • 46.11 (a)
Dpck 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea T05G5.5 35
  • 48.27 (n)
  • 39.62 (a)
T05G5.5 36
  • 34 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL110C 35
  • 53.46 (n)
  • 40.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB5 35
  • 46.32 (n)
  • 41.78 (a)
CAB5 36
  • 34 (a)
OneToOne
CAB5 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18711g 35
  • 46.45 (n)
  • 41.2 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATCOAE 35
  • 46.36 (n)
  • 40.47 (a)
rice
(Oryza sativa)
Liliopsida Os01g0360600 35
  • 50.09 (n)
  • 45.99 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00369 35
  • 53.41 (n)
  • 43.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC14G10.01 35
  • 48.33 (n)
  • 46.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
OneToOne
Species with no ortholog for DCAKD:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAKD Gene

ENSEMBL:
Gene Tree for DCAKD (if available)
TreeFam:
Gene Tree for DCAKD (if available)

Paralogs for DCAKD Gene

Selected SIMAP similar genes for DCAKD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAKD: view

No data available for Paralogs for DCAKD Gene

Variants for DCAKD Gene

Sequence variations from dbSNP and Humsavar for DCAKD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs12568 -- 45,023,463(-) CCTAC(G/T)AGACT utr-variant-3-prime
rs708381 -- 45,025,220(-) AGGAG(A/G)TATTT intron-variant
rs730953 -- 45,024,918(+) GCCTC(A/C)CACCC intron-variant
rs3837839 -- 45,024,340(+) GTGTG(G/T)GGAGG utr-variant-3-prime
rs4315379 -- 45,051,201(+) TAAAG(C/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAKD Gene

Variant ID Type Subtype PubMed ID
nsv833457 CNV Loss 17160897
nsv527788 CNV Loss 19592680
nsv908289 CNV Loss 21882294
esv2674469 CNV Deletion 23128226
esv2438788 CNV Deletion 19546169
esv1217416 CNV Deletion 17803354

Relevant External Links for DCAKD Gene

HapMap Linkage Disequilibrium report
DCAKD
Human Gene Mutation Database (HGMD)
DCAKD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAKD Gene

Disorders for DCAKD Gene

Relevant External Links for DCAKD

Genetic Association Database (GAD)
DCAKD
Human Genome Epidemiology (HuGE) Navigator
DCAKD
genes like me logo Genes that share disorders with DCAKD: view

No data available for UniProtKB/Swiss-Prot for DCAKD Gene

Publications for DCAKD Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3

Products for DCAKD Gene

Sources for DCAKD Gene

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