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Aliases for DCAKD Gene

Aliases for DCAKD Gene

  • Dephospho-CoA Kinase Domain Containing 2 3 5
  • EC 63

External Ids for DCAKD Gene

Previous GeneCards Identifiers for DCAKD Gene

  • GC17M040457
  • GC17M043100
  • GC17M038864

Summaries for DCAKD Gene

GeneCards Summary for DCAKD Gene

DCAKD (Dephospho-CoA Kinase Domain Containing) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include dephospho-CoA kinase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAKD Gene

Genomics for DCAKD Gene

Regulatory Elements for DCAKD Gene

Enhancers for DCAKD Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCAKD on UCSC Golden Path with GeneCards custom track

Promoters for DCAKD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCAKD on UCSC Golden Path with GeneCards custom track

Genomic Location for DCAKD Gene

45,023,338 bp from pter
45,061,141 bp from pter
37,804 bases
Minus strand

Genomic View for DCAKD Gene

Genes around DCAKD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAKD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAKD Gene

Proteins for DCAKD Gene

  • Protein details for DCAKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dephospho-CoA kinase domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A8K3Z0
    • D3DX60
    • D3DX62
    • Q9BR71
    • Q9H5W1

    Protein attributes for DCAKD Gene

    231 amino acids
    Molecular mass:
    26550 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCAKD Gene


neXtProt entry for DCAKD Gene

Proteomics data for DCAKD Gene at MOPED

Selected DME Specific Peptides for DCAKD Gene

Post-translational modifications for DCAKD Gene

  • Ubiquitination at Lys 67, Lys 168, and Lys 186
  • Modification sites at PhosphoSitePlus

Domains & Families for DCAKD Gene

Protein Domains for DCAKD Gene

Suggested Antigen Peptide Sequences for DCAKD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DPCK (dephospho-CoA kinase) domain.
  • Belongs to the CoaE family.
  • Contains 1 DPCK (dephospho-CoA kinase) domain.
  • Belongs to the CoaE family.
genes like me logo Genes that share domains with DCAKD: view

No data available for Gene Families for DCAKD Gene

Function for DCAKD Gene

Enzyme Numbers (IUBMB) for DCAKD Gene

genes like me logo Genes that share phenotypes with DCAKD: view

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAKD Gene

Localization for DCAKD Gene

Subcellular locations from

Jensen Localization Image for DCAKD Gene COMPARTMENTS Subcellular localization image for DCAKD gene
Compartment Confidence
cytosol 3
mitochondrion 3
endoplasmic reticulum 1
extracellular 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCAKD Gene

Pathways & Interactions for DCAKD Gene

genes like me logo Genes that share pathways with DCAKD: view

Pathways by source for DCAKD Gene

1 BioSystems pathway for DCAKD Gene

Interacting Proteins for DCAKD Gene

Gene Ontology (GO) - Biological Process for DCAKD Gene


No data available for SIGNOR curated interactions for DCAKD Gene

Drugs & Compounds for DCAKD Gene

No Compound Related Data Available

Transcripts for DCAKD Gene

Unigene Clusters for DCAKD Gene

Dephospho-CoA kinase domain containing:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAKD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for DCAKD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAKD Gene

mRNA expression in normal human tissues for DCAKD Gene

Protein differential expression in normal tissues from HIPED for DCAKD Gene

This gene is overexpressed in Nasal epithelium (27.3) and Bone (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAKD Gene

SOURCE GeneReport for Unigene cluster for DCAKD Gene Hs.463148

genes like me logo Genes that share expression patterns with DCAKD: view

Protein tissue co-expression partners for DCAKD Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAKD Gene

Orthologs for DCAKD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAKD Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCAKD 35
  • 89.55 (n)
  • 94.03 (a)
  • 90 (a)
(Canis familiaris)
Mammalia DCAKD 35
  • 87.92 (n)
  • 92.2 (a)
  • 91 (a)
(Mus musculus)
Mammalia Dcakd 35
  • 86.09 (n)
  • 91.74 (a)
Dcakd 16
Dcakd 36
  • 91 (a)
(Pan troglodytes)
Mammalia DCAKD 35
  • 99.13 (n)
  • 98.7 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dcakd 35
  • 87 (n)
  • 91.28 (a)
(Monodelphis domestica)
Mammalia DCAKD 36
  • 65 (a)
(Gallus gallus)
Aves DCAKD 35
  • 67.13 (n)
  • 62.67 (a)
  • 61 (a)
(Anolis carolinensis)
Reptilia DCAKD 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcakd 35
  • 60.55 (n)
  • 58.72 (a)
Str.7183 35
(Danio rerio)
Actinopterygii dcakd 35
  • 61.42 (n)
  • 56.94 (a)
dcakd 36
  • 53 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004425 35
  • 51.16 (n)
  • 43.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dpck 35
  • 55.19 (n)
  • 46.11 (a)
Dpck 36
  • 38 (a)
(Caenorhabditis elegans)
Secernentea T05G5.5 35
  • 48.27 (n)
  • 39.62 (a)
T05G5.5 36
  • 34 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL110C 35
  • 53.46 (n)
  • 40.55 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18711g 35
  • 46.45 (n)
  • 41.2 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB5 35
  • 46.32 (n)
  • 41.78 (a)
CAB5 36
  • 34 (a)
CAB5 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ATCOAE 35
  • 46.36 (n)
  • 40.47 (a)
(Oryza sativa)
Liliopsida Os01g0360600 35
  • 50.09 (n)
  • 45.99 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00369 35
  • 53.41 (n)
  • 43.27 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC14G10.01 35
  • 48.33 (n)
  • 46.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 41 (a)
Species with no ortholog for DCAKD:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAKD Gene

Gene Tree for DCAKD (if available)
Gene Tree for DCAKD (if available)

Paralogs for DCAKD Gene

(1) SIMAP similar genes for DCAKD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAKD: view

No data available for Paralogs for DCAKD Gene

Variants for DCAKD Gene

Sequence variations from dbSNP and Humsavar for DCAKD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs17850104 - 45,034,252(+) TGGCG(A/T)TGAGC reference, missense
rs12568 -- 45,023,463(-) CCTAC(G/T)AGACT utr-variant-3-prime
rs708381 -- 45,025,220(-) AGGAG(A/G)TATTT intron-variant
rs730953 -- 45,024,918(+) GCCTC(A/C)CACCC intron-variant
rs4315379 -- 45,051,201(+) TAAAG(C/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAKD Gene

Variant ID Type Subtype PubMed ID
nsv833457 CNV Loss 17160897
nsv527788 CNV Loss 19592680
nsv908289 CNV Loss 21882294
esv2674469 CNV Deletion 23128226
esv2438788 CNV Deletion 19546169
esv1217416 CNV Deletion 17803354

Variation tolerance for DCAKD Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAKD Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAKD Gene

Disorders for DCAKD Gene

Relevant External Links for DCAKD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCAKD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAKD Gene

Publications for DCAKD Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DCAKD Gene

Sources for DCAKD Gene