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Aliases for DCAKD Gene

Aliases for DCAKD Gene

  • Dephospho-CoA Kinase Domain Containing 2 3 5
  • EC 61

External Ids for DCAKD Gene

Previous GeneCards Identifiers for DCAKD Gene

  • GC17M040457
  • GC17M043100
  • GC17M038864

Summaries for DCAKD Gene

GeneCards Summary for DCAKD Gene

DCAKD (Dephospho-CoA Kinase Domain Containing) is a Protein Coding gene. Among its related pathways are Integrated Breast Cancer Pathway. GO annotations related to this gene include dephospho-CoA kinase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAKD Gene

Genomics for DCAKD Gene

Regulatory Elements for DCAKD Gene

Enhancers for DCAKD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F045089 1.8 FANTOM5 Ensembl ENCODE 34.9 -31.1 -31065 4.6 HDGF PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 DCAKD PLCD3 GFAP NMT1 ACBD4 HEXIM1 GPATCH8 ENSG00000224911 LOC102724391 EFTUD2
GH17F045143 1.6 FANTOM5 ENCODE 23.7 -86.8 -86806 9.6 CREB3L1 MLX YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 LOC102724391 ASB16-AS1 ENSG00000224505 EFTUD2 CRHR1-IT1 DCAKD ENSG00000260793 HEXIM1 ENSG00000267788 RN7SL405P
GH17F045042 1.4 Ensembl ENCODE 25.8 +15.0 15049 6.8 HDGF PKNOX1 MLX ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 LOC102724391 ASB16-AS1 DCAKD ENSG00000224505 GPATCH8 EFTUD2 ENSG00000266918 CRHR1-IT1 PLCD3 GJC1
GH17F045049 1.1 ENCODE 31 +9.8 9787 3.0 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 KLF13 ZNF263 DCAKD SLC25A39 NMT1 GC17M045043
GH17F045020 1.2 Ensembl ENCODE 27.3 +39.7 39717 2.5 ATF1 CREB3L1 ZFP64 ARID4B DMAP1 ZNF48 ZNF143 PAF1 ZNF263 SP5 DCAKD NMT1 C1QL1 GFAP ENSG00000224911 CCDC103 EFTUD2 FAM187A KIF18B HEXIM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCAKD on UCSC Golden Path with GeneCards custom track

Promoters for DCAKD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DCAKD Gene

45,023,338 bp from pter
45,061,141 bp from pter
37,804 bases
Minus strand

Genomic View for DCAKD Gene

Genes around DCAKD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAKD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAKD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAKD Gene

Proteins for DCAKD Gene

  • Protein details for DCAKD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dephospho-CoA kinase domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A8K3Z0
    • D3DX60
    • D3DX62
    • Q9BR71
    • Q9H5W1

    Protein attributes for DCAKD Gene

    231 amino acids
    Molecular mass:
    26550 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DCAKD Gene


neXtProt entry for DCAKD Gene

Selected DME Specific Peptides for DCAKD Gene


Post-translational modifications for DCAKD Gene

  • Ubiquitination at Lys 67, Lys 168, and Lys 186
  • Modification sites at PhosphoSitePlus

Domains & Families for DCAKD Gene

Protein Domains for DCAKD Gene

Suggested Antigen Peptide Sequences for DCAKD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DPCK (dephospho-CoA kinase) domain.
  • Belongs to the CoaE family.
  • Contains 1 DPCK (dephospho-CoA kinase) domain.
  • Belongs to the CoaE family.
genes like me logo Genes that share domains with DCAKD: view

No data available for Gene Families for DCAKD Gene

Function for DCAKD Gene

Enzyme Numbers (IUBMB) for DCAKD Gene

Gene Ontology (GO) - Molecular Function for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004140 dephospho-CoA kinase activity IBA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DCAKD: view
genes like me logo Genes that share phenotypes with DCAKD: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAKD Gene

Localization for DCAKD Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAKD gene
Compartment Confidence
mitochondrion 3
cytosol 3
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DCAKD: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAKD Gene

Pathways & Interactions for DCAKD Gene

genes like me logo Genes that share pathways with DCAKD: view

Pathways by source for DCAKD Gene

1 BioSystems pathway for DCAKD Gene

Gene Ontology (GO) - Biological Process for DCAKD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015937 coenzyme A biosynthetic process IBA --
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with DCAKD: view

No data available for SIGNOR curated interactions for DCAKD Gene

Transcripts for DCAKD Gene

Unigene Clusters for DCAKD Gene

Dephospho-CoA kinase domain containing:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAKD Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: - - - -

Relevant External Links for DCAKD Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAKD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCAKD Gene

Protein differential expression in normal tissues from HIPED for DCAKD Gene

This gene is overexpressed in Nasal epithelium (27.3) and Bone (12.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCAKD Gene

Protein tissue co-expression partners for DCAKD Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAKD Gene:


SOURCE GeneReport for Unigene cluster for DCAKD Gene:

genes like me logo Genes that share expression patterns with DCAKD: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAKD Gene

Orthologs for DCAKD Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAKD Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAKD 34 35
  • 99.13 (n)
(Bos Taurus)
Mammalia DCAKD 34 35
  • 89.55 (n)
(Canis familiaris)
Mammalia DCAKD 34 35
  • 87.92 (n)
(Rattus norvegicus)
Mammalia Dcakd 34
  • 87 (n)
(Mus musculus)
Mammalia Dcakd 34 16 35
  • 86.09 (n)
(Monodelphis domestica)
Mammalia DCAKD 35
  • 65 (a)
(Gallus gallus)
Aves DCAKD 34 35
  • 67.13 (n)
(Anolis carolinensis)
Reptilia DCAKD 35
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcakd 34
  • 60.55 (n)
Str.7183 34
(Danio rerio)
Actinopterygii dcakd 34 35
  • 61.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dpck 34 35
  • 55.19 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004425 34
  • 51.16 (n)
(Caenorhabditis elegans)
Secernentea T05G5.5 34 35
  • 48.27 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL110C 34
  • 53.46 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D18711g 34
  • 46.45 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CAB5 34 35 37
  • 46.32 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ATCOAE 34
  • 46.36 (n)
(Oryza sativa)
Liliopsida Os01g0360600 34
  • 50.09 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00369 34
  • 53.41 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPCC14G10.01 34
  • 48.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 41 (a)
Species where no ortholog for DCAKD was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAKD Gene

Gene Tree for DCAKD (if available)
Gene Tree for DCAKD (if available)

Paralogs for DCAKD Gene

(1) SIMAP similar genes for DCAKD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAKD: view

No data available for Paralogs for DCAKD Gene

Variants for DCAKD Gene

Sequence variations from dbSNP and Humsavar for DCAKD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10451271 -- 45,033,786(+) TCCCC(A/G)CTGCA intron-variant, downstream-variant-500B
rs10628158 -- 45,033,181(+) CTCTA(-/AAAAT/AAAATAAAAT)AAAAT intron-variant
rs10714830 -- 45,035,455(+) CAGCC(-/G)TGGGT intron-variant
rs111227883 -- 45,055,296(+) GTTTG(A/C)TGAAC intron-variant
rs111314266 -- 45,050,191(+) ATGCA(C/T)CACCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAKD Gene

Variant ID Type Subtype PubMed ID
nsv527788 CNV loss 19592680
nsv833457 CNV loss 17160897
nsv953902 CNV deletion 24416366
nsv1146669 OTHER inversion 26484159
nsv1144803 CNV deletion 24896259
nsv1072739 CNV deletion 25765185
esv3640657 CNV loss 21293372
esv2674469 CNV deletion 23128226
esv2438788 CNV deletion 19546169
esv1217416 CNV deletion 17803354

Variation tolerance for DCAKD Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAKD Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAKD Gene

Disorders for DCAKD Gene

Relevant External Links for DCAKD

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCAKD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAKD Gene

Publications for DCAKD Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3 64
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3 64

Products for DCAKD Gene

Sources for DCAKD Gene

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