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Aliases for DCAF8L2 Gene

Aliases for DCAF8L2 Gene

  • DDB1 And CUL4 Associated Factor 8-Like 2 2 3 5
  • WD Repeat-Containing Protein 42C 3 4
  • WD Repeat Domain 42C 2 3
  • WDR42C 3 4

External Ids for DCAF8L2 Gene

Previous HGNC Symbols for DCAF8L2 Gene

  • WDR42C

Previous GeneCards Identifiers for DCAF8L2 Gene

  • GC0XP027662
  • GC0XP027764
  • GC0XP025504

Summaries for DCAF8L2 Gene

GeneCards Summary for DCAF8L2 Gene

DCAF8L2 (DDB1 And CUL4 Associated Factor 8-Like 2) is a Protein Coding gene. An important paralog of this gene is WDTC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF8L2 Gene

Genomics for DCAF8L2 Gene

Regulatory Elements for DCAF8L2 Gene

Enhancers for DCAF8L2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCAF8L2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCAF8L2 Gene

27,590,382 bp from pter
27,748,821 bp from pter
158,440 bases
Plus strand

Genomic View for DCAF8L2 Gene

Genes around DCAF8L2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF8L2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF8L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF8L2 Gene

Proteins for DCAF8L2 Gene

  • Protein details for DCAF8L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 8-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RXH9
    • J3KT06

    Protein attributes for DCAF8L2 Gene

    631 amino acids
    Molecular mass:
    71191 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF8L2 Gene

Proteomics data for DCAF8L2 Gene at MOPED

Post-translational modifications for DCAF8L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF8L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF8L2 Gene

Domains & Families for DCAF8L2 Gene

Gene Families for DCAF8L2 Gene

Protein Domains for DCAF8L2 Gene

Suggested Antigen Peptide Sequences for DCAF8L2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat DCAF8 family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat DCAF8 family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF8L2: view

Function for DCAF8L2 Gene

Phenotypes for DCAF8L2 Gene

genes like me logo Genes that share phenotypes with DCAF8L2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DCAF8L2 Gene

Localization for DCAF8L2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DCAF8L2 Gene

Pathways & Interactions for DCAF8L2 Gene

SuperPathways for DCAF8L2 Gene

No Data Available

Interacting Proteins for DCAF8L2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000462745 for DCAF8L2 Gene via STRING

Gene Ontology (GO) - Biological Process for DCAF8L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCAF8L2 Gene

Drugs & Compounds for DCAF8L2 Gene

No Compound Related Data Available

Transcripts for DCAF8L2 Gene

mRNA/cDNA for DCAF8L2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF8L2 Gene

DDB1 and CUL4 associated factor 8-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF8L2 Gene

No ASD Table

Relevant External Links for DCAF8L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF8L2 Gene

mRNA expression in normal human tissues for DCAF8L2 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF8L2 Gene

This gene is overexpressed in Testis (x51.4).

Protein differential expression in normal tissues from HIPED for DCAF8L2 Gene

This gene is overexpressed in Ovary (49.9) and Testis (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DCAF8L2 Gene

SOURCE GeneReport for Unigene cluster for DCAF8L2 Gene Hs.720885

genes like me logo Genes that share expression patterns with DCAF8L2: view

Protein tissue co-expression partners for DCAF8L2 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DCAF8L2 Gene

Orthologs for DCAF8L2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF8L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF8L2 35
  • 98.31 (n)
  • 98.1 (a)
DCAF8L2 36
  • 98 (a)
(Canis familiaris)
Mammalia -- 36
  • 69 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
(Mus musculus)
Mammalia Pet2 36
  • 47 (a)
(Gallus gallus)
Aves -- 36
  • 66 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
(Danio rerio)
Actinopterygii DCAF8 36
  • 52 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8001 36
  • 26 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35140 35
  • 49.25 (n)
  • 44.66 (a)
(Oryza sativa)
Liliopsida Os10g0544500 35
  • 48.34 (n)
  • 40.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9303 36
  • 49 (a)
Species with no ortholog for DCAF8L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF8L2 Gene

Gene Tree for DCAF8L2 (if available)
Gene Tree for DCAF8L2 (if available)

Paralogs for DCAF8L2 Gene

Paralogs for DCAF8L2 Gene

(2) SIMAP similar genes for DCAF8L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAF8L2: view

Variants for DCAF8L2 Gene

Sequence variations from dbSNP and Humsavar for DCAF8L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs5926895 - 27,747,928(+) TCTTC(A/G)CCATT reference, missense
rs748021210 -- 27,747,048(+) GTGAC(C/T)GGAGA reference, synonymous-codon
rs748152249 -- 27,747,356(+) TCCAC(A/G)AGGCA reference, missense
rs748326978 -- 27,747,687(+) GTACT(G/T)AACTT reference, synonymous-codon
rs748449236 -- 27,747,862(+) CCCAC(A/G)AGTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DCAF8L2 Gene

Variant ID Type Subtype PubMed ID
nsv526948 CNV Gain 19592680
nsv521729 CNV Gain 19592680
nsv508756 CNV Insertion 20534489

Variation tolerance for DCAF8L2 Gene

Residual Variation Intolerance Score: 73.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.04; 80.23% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DCAF8L2 Gene

Disorders for DCAF8L2 Gene

Relevant External Links for DCAF8L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCAF8L2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF8L2 Gene

Publications for DCAF8L2 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DCAF8L2 Gene

Sources for DCAF8L2 Gene