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Aliases for DCAF8L2 Gene

Aliases for DCAF8L2 Gene

  • DDB1 And CUL4 Associated Factor 8-Like 2 2 3
  • WD Repeat-Containing Protein 42C 3 4
  • WD Repeat Domain 42C 2 3
  • WDR42C 3 4
  • DDB1- And CUL4-Associated Factor 8-Like Protein 2 3

External Ids for DCAF8L2 Gene

Previous HGNC Symbols for DCAF8L2 Gene

  • WDR42C

Previous GeneCards Identifiers for DCAF8L2 Gene

  • GC0XP027662
  • GC0XP027764
  • GC0XP025504

Summaries for DCAF8L2 Gene

GeneCards Summary for DCAF8L2 Gene

DCAF8L2 (DDB1 And CUL4 Associated Factor 8-Like 2) is a Protein Coding gene. An important paralog of this gene is DCAF8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF8L2 Gene

Genomics for DCAF8L2 Gene

Genomic Location for DCAF8L2 Gene

Start:
27,590,382 bp from pter
End:
27,748,821 bp from pter
Size:
158,440 bases
Orientation:
Plus strand

Genomic View for DCAF8L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF8L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF8L2 Gene

No data available for Regulatory Elements for DCAF8L2 Gene

Proteins for DCAF8L2 Gene

  • Protein details for DCAF8L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7V8-DC8L2_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 8-like protein 2
    Protein Accession:
    P0C7V8
    Secondary Accessions:
    • B2RXH9
    • J3KT06

    Protein attributes for DCAF8L2 Gene

    Size:
    631 amino acids
    Molecular mass:
    71191 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF8L2 Gene

Proteomics data for DCAF8L2 Gene at MOPED

Post-translational modifications for DCAF8L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF8L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF8L2 Gene

Domains for DCAF8L2 Gene

Gene Families for DCAF8L2 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for DCAF8L2 Gene

Suggested Antigen Peptide Sequences for DCAF8L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7V8

UniProtKB/Swiss-Prot:

DC8L2_HUMAN :
  • P0C7V8
Family:
  • Belongs to the WD repeat DCAF8 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF8L2: view

Function for DCAF8L2 Gene

Gene Ontology (GO) - Molecular Function for DCAF8L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF8L2: view

Phenotypes for DCAF8L2 Gene

GenomeRNAi human phenotypes for DCAF8L2:
genes like me logo Genes that share phenotypes with DCAF8L2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF8L2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DCAF8L2 Gene

Localization for DCAF8L2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DCAF8L2 Gene

Pathways for DCAF8L2 Gene

SuperPathways for DCAF8L2 Gene

No Data Available

Interacting Proteins for DCAF8L2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000462745%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000301764%0d%0a
Selected Interacting proteins: ENSP00000462745 for DCAF8L2 Gene via STRING

Gene Ontology (GO) - Biological Process for DCAF8L2 Gene

None

No data available for Pathways by source for DCAF8L2 Gene

Transcripts for DCAF8L2 Gene

mRNA/cDNA for DCAF8L2 Gene

(1) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF8L2 Gene

DDB1 and CUL4 associated factor 8-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF8L2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DCAF8L2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF8L2 Gene

No ASD Table

Relevant External Links for DCAF8L2 Gene

GeneLoc Exon Structure for
DCAF8L2
ECgene alternative splicing isoforms for
DCAF8L2

Expression for DCAF8L2 Gene

mRNA expression in normal human tissues for DCAF8L2 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF8L2 Gene

This gene is overexpressed in Testis (51.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF8L2 Gene

SOURCE GeneReport for Unigene cluster for DCAF8L2 Gene Hs.720885

genes like me logo Genes that share expressions with DCAF8L2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DCAF8L2 Gene

Orthologs for DCAF8L2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF8L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF8L2 35
  • 98.31 (n)
  • 98.1 (a)
DCAF8L2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 69 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pet2 36
  • 47 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 66 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii DCAF8 36
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8001 36
  • 26 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G35140 35
  • 49.25 (n)
  • 44.66 (a)
rice
(Oryza sativa)
Liliopsida Os10g0544500 35
  • 48.34 (n)
  • 40.66 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9303 36
  • 49 (a)
OneToMany
Species with no ortholog for DCAF8L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF8L2 Gene

ENSEMBL:
Gene Tree for DCAF8L2 (if available)
TreeFam:
Gene Tree for DCAF8L2 (if available)

Paralogs for DCAF8L2 Gene

Paralogs for DCAF8L2 Gene

Selected SIMAP similar genes for DCAF8L2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAF8L2: view

Variants for DCAF8L2 Gene

Sequence variations from dbSNP and Humsavar for DCAF8L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1811385 -- 27,747,972(-) GTGGT(A/T)ACAAG reference, synonymous-codon
rs5926894 -- 27,745,661(+) ATTTA(C/T)CTTGC upstream-variant-2KB
rs5926895 - 27,747,928(+) TCTTC(A/G)CCATT reference, missense
rs7880663 -- 27,745,467(+) CATTC(C/T)CACTT upstream-variant-2KB
rs16987980 -- 27,749,318(+) GCCGC(A/T)CACAC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DCAF8L2 Gene

Variant ID Type Subtype PubMed ID
nsv526948 CNV Gain 19592680
nsv521729 CNV Gain 19592680
nsv508756 CNV Insertion 20534489

Relevant External Links for DCAF8L2 Gene

HapMap Linkage Disequilibrium report
DCAF8L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF8L2 Gene

Disorders for DCAF8L2 Gene

No disorders were found for DCAF8L2 Gene.

No data available for UniProtKB/Swiss-Prot for DCAF8L2 Gene

Publications for DCAF8L2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for DCAF8L2 Gene

Sources for DCAF8L2 Gene

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