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Aliases for DCAF8L1 Gene

Aliases for DCAF8L1 Gene

  • DDB1 And CUL4 Associated Factor 8-Like 1 2 3
  • WD Repeat-Containing Protein 42B 3 4
  • WD Repeat Domain 42B 2 3
  • WDR42B 3 4
  • DDB1- And CUL4-Associated Factor 8-Like Protein 1 3

External Ids for DCAF8L1 Gene

Previous Symbols for DCAF8L1 Gene

  • WDR42B

Summaries for DCAF8L1 Gene

Entrez Gene Summary for DCAF8L1 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate the formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 1. However, the CDS of this intronless gene remains intact, it is conserved in other primate species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]

GeneCards Summary for DCAF8L1 Gene

DCAF8L1 (DDB1 And CUL4 Associated Factor 8-Like 1) is a Protein Coding gene. An important paralog of this gene is DCAF8.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF8L1 Gene

Genomics for DCAF8L1 Gene

Genomic Location for DCAF8L1 Gene

Start:
27,977,993 bp from pter
End:
27,981,449 bp from pter
Size:
3,457 bases
Orientation:
Minus strand

Genomic View for DCAF8L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF8L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF8L1 Gene

No data available for Regulatory Elements for DCAF8L1 Gene

Proteins for DCAF8L1 Gene

  • Protein details for DCAF8L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NGE4-DC8L1_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 8-like protein 1
    Protein Accession:
    A6NGE4
    Secondary Accessions:
    • B3KXX1

    Protein attributes for DCAF8L1 Gene

    Size:
    600 amino acids
    Molecular mass:
    67373 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF8L1 Gene

Proteomics data for DCAF8L1 Gene at MOPED

Post-translational modifications for DCAF8L1 Gene

No Post-translational modifications

Other Protein References for DCAF8L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF8L1 Gene

Domains for DCAF8L1 Gene

Gene Families for DCAF8L1 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for DCAF8L1 Gene

UniProtKB/Swiss-Prot:

DC8L1_HUMAN
Family:
  • Belongs to the WD repeat DCAF8 family.:
    • A6NGE4
Similarity:
  • Contains 7 WD repeats.:
    • A6NGE4
genes like me logo Genes that share domains with DCAF8L1: view

Function for DCAF8L1 Gene

Gene Ontology (GO) - Molecular Function for DCAF8L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF8L1: view

Phenotypes for DCAF8L1 Gene

GenomeRNAi human phenotypes for DCAF8L1:
genes like me logo Genes that share phenotypes with DCAF8L1: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DCAF8L1 Gene

Localization for DCAF8L1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF8L1 Gene COMPARTMENTS Subcellular localization image for DCAF8L1 gene
Compartment Confidence
cytosol 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for DCAF8L1 Gene

Pathways for DCAF8L1 Gene

SuperPathways for DCAF8L1 Gene

No Data Available

Interacting Proteins for DCAF8L1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000405222%0d%0a9606.ENSP00000301764%0d%0a
Selected Interacting proteins: ENSP00000405222 for DCAF8L1 Gene via STRING

Symbol External ID(s) Details
DDB1

Gene Ontology (GO) - Biological Process for DCAF8L1 Gene

None

No data available for Pathways by source for DCAF8L1 Gene

Transcripts for DCAF8L1 Gene

mRNA/cDNA for DCAF8L1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF8L1 Gene

DDB1 and CUL4 associated factor 8-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF8L1 Gene

No ASD Table

Relevant External Links for DCAF8L1 Gene

GeneLoc Exon Structure for
DCAF8L1
ECgene alternative splicing isoforms for
DCAF8L1

Expression for DCAF8L1 Gene

mRNA expression in normal human tissues for DCAF8L1 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF8L1 Gene

This gene is overexpressed in Testis (44.4) and Bladder (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DCAF8L1 Gene

SOURCE GeneReport for Unigene cluster for DCAF8L1 Gene Hs.447365

genes like me logo Genes that share expressions with DCAF8L1: view

Orthologs for DCAF8L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF8L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF8L1 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 66 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Pet2 37
  • 43 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 48 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii DCAF8 37
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8001 37
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9303 37
  • 48 (a)
OneToMany
Species with no ortholog for DCAF8L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF8L1 Gene

ENSEMBL:
Gene Tree for DCAF8L1 (if available)
TreeFam:
Gene Tree for DCAF8L1 (if available)

Paralogs for DCAF8L1 Gene

Paralogs for DCAF8L1 Gene

Selected SIMAP similar genes for DCAF8L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCAF8L1: view

Variants for DCAF8L1 Gene

Sequence variations from dbSNP and Humsavar for DCAF8L1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs5901878 -- 27,979,258(+) AAACT(-/A)AAAAA utr-variant-3-prime
rs6653789 -- 27,977,499(+) ACATT(C/T)TCCCC downstream-variant-500B
rs6653790 -- 27,978,905(+) TGTTT(C/T)CTTTC utr-variant-3-prime
rs12011589 -- 27,983,071(+) gcatg(A/G)ttctt upstream-variant-2KB
rs12014586 -- 27,981,466(+) ACCAA(C/T)CCGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DCAF8L1 Gene

Variant ID Type Subtype PubMed ID
nsv518944 CNV Gain 19592680
nsv6839 CNV Loss 18451855

Relevant External Links for DCAF8L1 Gene

HapMap Linkage Disequilibrium report
DCAF8L1
Locus Specific Mutation Databases (LSDB)
DCAF8L1

Disorders for DCAF8L1 Gene

Relevant External Links for DCAF8L1

Genetic Association Database (GAD)
DCAF8L1
genes like me logo Genes that share disorders with DCAF8L1: view

No data available for UniProtKB/Swiss-Prot for DCAF8L1 Gene

Publications for DCAF8L1 Gene

  1. Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer. (PMID: 20932654) Kerns S.L. … Rosenstein B.S. (Int. J. Radiat. Oncol. Biol. Phys. 2010) 3 49
  2. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk J.B. … O'Connor G.T. (BMC Med. Genet. 2007) 49
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4
  5. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3

Products for DCAF8L1 Gene

Sources for DCAF8L1 Gene

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