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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DCAF8L1 Gene

protein-coding GIFtS: 37
GCID: GC0XM027996

DDB1 and CUL4 associated factor 8-like 1

(Previous name: WD repeat domain 42B )
(Previous symbol: WDR42B)

Explore 3 diseases affiliated with
DCAF8L1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DDB1 And CUL4 Associated Factor 8-Like 1¹ ²
WDR42B¹ ² ³
WD Repeat Domain 42B¹ ²
WD Repeat-Containing Protein 42B² ³
DDB1- And CUL4-Associated Factor 8-Like Protein 1²

External Ids:	HGNC: 31810¹	Entrez Gene: 139425²	Ensembl: ENSG00000226372⁷	UniProtKB: A6NGE4³

Export aliases for DCAF8L1 gene to outside databases

Previous GC identifers: GC0XM027907 GC0XM025736

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCAF8L1:

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately

40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate the formation of

heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes,

including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent

an intronless retrocopy of a related multi-exon gene located on chromosome 1. However, the CDS of this intronless gene

remains intact, it is conserved in other primate species, it is known to be transcribed, and it is therefore thought

to encode a functional protein. (provided by RefSeq, May 2010)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_167197.1

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for DCAF8L1
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF8L1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp21.3 Ensembl cytogenetic band: Xp21.3 HGNC cytogenetic band: Xp22.11

DCAF8L1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF8L1 gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM027996: view genomic region (about GC identifiers)

Start:	27,996,110 bp from pter	End:	27,999,566 bp from pter
Size:	3,457 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: DC8L1_HUMAN, A6NGE4 (See protein sequence)

Recommended Name: DDB1- and CUL4-associated factor 8-like protein 1

Size: 600 amino acids; 67373 Da

Secondary accessions: B3KXX1

Explore the universe of human proteins at neXtProt for DCAF8L1: NX_A6NGE4

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_A6NGE4

DCAF8L1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001017930.1

ENSEMBL proteins:

ENSP00000405222

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DCAF8L1 for domains About GeneDecksing

3 InterPro domains/families:

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry A6NGE4

ProtoNet protein and cluster: A6NGE4

UniProtKB/Swiss-Prot: DC8L1_HUMAN, A6NGE4

Similarity: Belongs to the WD repeat DCAF8 family

Similarity: Contains 7 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for DCAF8L1:

Proliferating cells

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DCAF8L1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for DCAF8L1 gene:

NM_001017930.1

Unigene Cluster for DCAF8L1:

DDB1 and CUL4 associated factor 8-like 1

Hs.447365 [show with all ESTs]

Unigene Representative Sequence: AK128123

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000441525(uc004dbx.1)

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Additional cDNA sequence: AK128123.1

1 DOTS entry:

DT.101961017

2 AceView cDNA sequences:

AK128123 BU570685

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DCAF8L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GATTGCTTAA

About this image
See DCAF8L1 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.447365

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF8L1 gene from 5/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	47(a)	1 → many	GL343637.1(289026-317879)
zebrafish (Danio rerio)	Actinopterygii	si:dkey-75g22.6⁶	si:dkey-75g22.6	50(a)	1 → many	2(37704438-37725422)
fruit fly (Drosophila melanogaster)	Insecta	CG8001⁶	--	23(a)	1 → many	3L(1756159-1759208)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT4G38480⁶ AT4G35140⁶ (see all 3)	WD repeat-containing protein 42A (see all 3)	30(a) 30(a) (see all 3)	many ↔ many many ↔ many (see all 3)	4(18003916-18006140) 4(16723714-16726636)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	WD domain, G-beta repeat domain containing protein... WD domain, G-beta repeat domain containing protein... (see all 3)	35(a) 28(a) (see all 3)	many ↔ many many ↔ many (see all 3)	3(9892357-9895569) 10(21182045-21185175)

ENSEMBL Gene Tree for DCAF8L1 (if available)
TreeFam Gene Tree for DCAF8L1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DCAF8L1 gene

DCAF5² ENSG00000258465² DCAF8² WDTC1² DCAF8L2² DCAF6²

3 SIMAP similar genes for DCAF8L1 using alignment to 1 protein entry: DC8L1_HUMAN:

DCAF8L2 WDR42C DCAF8

DCAF8L1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6653789^1,2	C,H,	--	27995616(+)	`ACATTT/CTCCCC`	1	--	ds500¹		5		NS EA CSA	411
rs73542697^1,2	C,	--	27995966(+)	`GGTTGT/CTGCGA`	1	--	ds500¹		2		WA CSA	3
rs149811412^1,2		--	27996064(+)	`GTGTTA/GGGGAA`	1	--	ds500¹		0	--	--	--	--
rs113759644^1,2	C,	--	27996073(+)	`AAAAGA/GTGATC`	1	--	ds500¹		1		CSA	1
rs190937563^1,2		--	27996148(+)	`TTTAAC/TATCTA`	1	--	ut3¹		0	--	--	--	--
rs182641406^1,2		--	27996194(+)	`ATTTTC/TAAAAC`	1	--	ut3¹		0	--	--	--	--
rs73628870^1,2	C,	--	27996301(+)	`TTTTAT/CTGCAA`	1	--	ut3¹		1		WA	2
rs145254507^1,2		--	27996427(+)	`TTTTCA/GAAACA`	1	--	ut3¹		0	--	--	--	--
rs62590483^1,2	C,	--	27996524(+)	`ATAAAT/CAATTT`	1	--	ut3¹		1		NA	2
rs186442107^1,2		--	27996734(+)	`TTTAGC/TTCTTA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DCAF8L1 (27996110 - 27999566 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DCAF8L1
1 CNV: 3265
Locus Specific Mutation Databases (LSDB): DCAF8L1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DCAF8L1 for disorders About GeneDecksing

3 diseases for DCAF8L1: About MalaCards

plasmacytoma prostate cancer prostatitis

Export disorders for DCAF8L1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DCAF8L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DCAF8L1)

Utopia: connect your pdf to the dynamic
world of online information

Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)¹ Kerns S.L....Rosenstein B.S. (2010)
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)¹ Jin J.... Walter J.C. (2006)
The DNA sequence of the human X chromosome. (PubMed id 15772651)² Ross M.T.... Bentley D.R. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 139425	HGNC: 31810	AceView: WDR42B	Ensembl:ENSG00000226372	euGenes: HUgn139425
ECgene: DCAF8L1	H-InvDB: DCAF8L1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DCAF8L1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DCAF8L1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DCAF8L1 gene:
Search GeneIP for patents involving DCAF8L1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DCAF8L1 gene at Home site.

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DCAF8L1 Gene

DDB1 and CUL4 associated factor 8-like 1

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DCAF8L1 Gene

DDB1 and CUL4 associated factor 8-like 1

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