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DCAF8 Gene

protein-coding   GIFtS: 47
GCID: GC01M160185

DDB1 And CUL4 Associated Factor 8

(Previous name: WD repeat domain 42A)
(Previous symbol: WDR42A)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DDB1 And CUL4 Associated Factor 81 2
WDR42A1 2 3
WD Repeat Domain 42A1 2
H3262 3
WD Repeat-Containing Protein 42A2 3
DDB1- And CUL4-Associated Factor 82

External Ids:    HGNC: 248911   Entrez Gene: 507172   Ensembl: ENSG000001327167   UniProtKB: Q5TAQ93   

Export aliases for DCAF8 gene to outside databases

Previous GC identifers: GC01M158453 GC01M131542


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCAF8 Gene:
This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular
complex. Multiple alternatively spliced transcript variants have been found for this gene. (provided by RefSeq,
Jul 2009)

GeneCards Summary for DCAF8 Gene:
DCAF8 (DDB1 and CUL4 associated factor 8) is a protein-coding gene. Diseases associated with DCAF8 include neural tube defects, and herpes simplex. An important paralog of this gene is ENSG00000258465.

UniProtKB/Swiss-Prot: DCAF8_HUMAN, Q5TAQ9
Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DCAF8
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCAF8 promoter sequence
   Search Chromatin IP Primers for DCAF8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCAF8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22-q23   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q22-q23

DCAF8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF8 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M160185:  view genomic region     (about GC identifiers)

Start:
160,185,505 bp from pter      End:
160,254,920 bp from pter
Size:
69,416 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DCAF8

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DCAF8_HUMAN, Q5TAQ9 (See protein sequence)
Recommended Name: DDB1- and CUL4-associated factor 8  
Size: 597 amino acids; 66852 Da
Subunit: Interacts with DDB1, CUL4A and CUL4B
Sequence caution: Sequence=AAA16607.1; Type=Frameshift; Positions=117, 123;
1 PDB 3D structure from and Proteopedia for DCAF8:
3I8E (3D)    
Secondary accessions: D3DVE6 Q12839 Q4QQI6 Q53F14 Q66K50 Q68CS7 Q96E00
Alternative splicing: 2 isoforms:  Q5TAQ9-1   Q5TAQ9-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCAF8: NX_Q5TAQ9

Explore proteomics data for DCAF8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys236, Lys363, Lys438
  • Modification sites at PhosphoSitePlus

  • See DCAF8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056541.2  
    ENSEMBL proteins: 
     ENSP00000357052   ENSP00000318227   ENSP00000357053   ENSP00000477386   ENSP00000476539  
     ENSP00000476407   ENSP00000477255   ENSP00000477464   ENSP00000476351   ENSP00000413688  
     ENSP00000477012   ENSP00000411875   ENSP00000384118   ENSP00000409434   ENSP00000476284  

    DCAF8 Human Recombinant Protein Products:

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    Novus Biologicals DCAF8 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCAF8

    DCAF8 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Search for Antibodies for DCAF8 at Abcam
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    LSBio Antibodies in human, mouse, rat for DCAF8

    DCAF8 Assay Products:

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    Cloud-Clone Corp. ELISAs for DCAF8
    Cloud-Clone Corp. CLIAs for DCAF8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5TAQ9

    ProtoNet protein and cluster: Q5TAQ9

    UniProtKB/Swiss-Prot: DCAF8_HUMAN, Q5TAQ9
    Similarity: Belongs to the WD repeat DCAF8 family
    Similarity: Contains 7 WD repeats


    DCAF8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCAF8_HUMAN, Q5TAQ9
    Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
         
    DCAF8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCAF8
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    miRNA
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    miRTarBase miRNAs that target DCAF8:
    hsa-mir-130b-3p (MIRT020276), hsa-mir-937-3p (MIRT036637), hsa-let-7g-5p (MIRT046555), hsa-mir-21-5p (MIRT031024), hsa-mir-93-5p (MIRT028104), hsa-mir-877-3p (MIRT037018), hsa-mir-296-3p (MIRT038497), hsa-mir-26b-5p (MIRT030174), hsa-let-7e-5p (MIRT051435), hsa-mir-19b-3p (MIRT031233)

    Block miRNA regulation of human, mouse, rat DCAF8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF8 (see all 77):
    hsa-miR-15a hsa-miR-106a hsa-miR-759 hsa-miR-519a hsa-miR-3142 hsa-miR-93 hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidDCAF8 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DCAF8

    Gene Editing
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCAF8 (NM_015726)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCAF8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF8

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF8


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005777peroxisome ----
    GO:0080008Cul4-RING ubiquitin ligase complex IDA16949367

    DCAF8 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: DCAF8_HUMAN, Q5TAQ9
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCAF8
    Interactions:

        Search GeneGlobe Interaction Network for DCAF8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCAF8 (Q5TAQ91, 2, 3 ENSP000003182274) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    KPNA1P522941, 2, ENSP000003437014EBI-740686,EBI-358383 MINT-8328646 MINT-8328661 STRING: ENSP00000343701
    MDFIQ997501, 2, 3, ENSP000002303214EBI-740686,EBI-724076 MINT-67377 I2D: score=5 STRING: ENSP00000230321
    DDB1Q165313, ENSP000003017644I2D: score=2 STRING: ENSP00000301764
    GTPBP3Q969Y23, ENSP000003516444I2D: score=5 STRING: ENSP00000351644
    CUL4AQ136193, ENSP000003645894I2D: score=1 STRING: ENSP00000364589
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    DCAF8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCAF8



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCAF8 gene: 
    NM_015726.3  

    Unigene Cluster for DCAF8:

    DDB1 and CUL4 associated factor 8
    Hs.632447  [show with all ESTs]
    Unigene Representative Sequence: NR_028103
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
    ENST00000368073(uc001fvn.2 uc009wth.2 uc001fvr.2) ENST00000326837(uc001fvo.2)
    ENST00000368074(uc010pjb.1 uc010pjc.1) ENST00000477163 ENST00000473382
    ENST00000476033 ENST00000461888 ENST00000490368 ENST00000497354 ENST00000481831
    ENST00000466253 ENST00000610139 ENST00000475733(uc001fvq.4 uc001fvp.4)
    ENST00000447377 ENST00000495887 ENST00000440682 ENST00000407642 ENST00000419626

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DCAF8 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF8 (see all 77):
    hsa-miR-15a hsa-miR-106a hsa-miR-759 hsa-miR-519a hsa-miR-3142 hsa-miR-93 hsa-miR-92b hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidDCAF8 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DCAF8
    Predesigned siRNA for gene silencing in human, mouse, rat DCAF8
    Clone
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    OriGene clones in human, mouse for DCAF8 (see all 6)
    OriGene ORF clones in mouse, rat for DCAF8
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCAF8 (NM_015726)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCAF8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF8
    Primer
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    OriGene qPCR primer pairs and template standards for DCAF8
    OriGene qSTAR qPCR primer pairs in human, mouse for DCAF8
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCAF8
      QuantiTect SYBR Green Assays in human, mouse, rat DCAF8
      QuantiFast Probe-based Assays in human, mouse, rat DCAF8

    Additional mRNA sequence: 

    AK093176.1 AK223475.1 AK303188.1 AK312690.1 BC013107.1 BC080597.1 BC098245.1 BC098271.1 
    BC099709.1 BC099846.1 BC111063.1 CR749801.1 NR_028103.1 NR_028104.1 NR_028105.1 NR_028106.1 
    U06631.1 

    Selected DOTS entries (see all 35):

    DT.92051950  DT.100717839  DT.100832270  DT.92437277  DT.95116105  DT.121410933  DT.92437269  DT.100743160 
    DT.75169508  DT.121410755  DT.87015963  DT.451997  DT.70104362  DT.100797017  DT.121410772  DT.100797018 
    DT.92437273  DT.95150538  DT.101982429  DT.95150536  DT.95359769  DT.121410851  DT.121410890  DT.40263756 

    8 AceView cDNA sequences:

    N45176 BF439213 BF060954 H59420 AA937174 N39328 H02445 H60073 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCAF8 (see all 29)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                -     -     -     -     -     -     -                       -                                                               
    SP4:                                -     -     -     -     -     -     -     -                 -                                                               
    SP5:                                            -     -     -     -     -                       -                                                               

    ExUns: 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
    SP1:                                                  -     -     -     -     -     -                 -                           
    SP2:                                                  -           -           -     -                                             
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for DCAF8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCAF8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCTGGAA
    DCAF8 Expression
    About this image


    DCAF8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    DCAF8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCAF8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632447
        Custom PCR Arrays for DCAF8
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DCAF8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCAF8 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcaf81 , 5 DDB1 and CUL4 associated factor 81, 5 91.69(n)1
    96.78(a)1
      1 (79.54 cM)5
    981931  NM_153555.21  NP_705783.11 
     1721480155 
    chicken
    (Gallus gallus)
    Aves DCAF81 DDB1 and CUL4 associated factor 8 79.31(n)
    89.66(a)
      429253  XM_426809.4  XP_426809.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    69(a)
    1 → many
    GL343637.1(289026-317879)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.254022 Xenopus laevis transcribed sequence with weak similarity more 83.6(n)    BJ037522.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000079241 DDB1- and CUL4-associated factor 8-like 65.07(n)
    64.96(a)
      100007924  XM_001346226.3  XP_001346262.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG80016
    --
    29(a)
    1 → many
    3L(1756159-1759208)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G456201 AT3G45620 48.48(n)
    42(a)
      823704  NM_001203085.1  NP_001190014.1 
    rice
    (Oryza sativa)
    Liliopsida Os03g02868001 Os03g0286800 52.17(n)
    46.05(a)
      4332480  NM_001056310.1  NP_001049775.1 


    ENSEMBL Gene Tree for DCAF8 (if available)
    TreeFam Gene Tree for DCAF8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCAF8 gene
    ENSG000002584652  DCAF8L22  WDTC12  DCAF62  DCAF8L12  
    5 SIMAP similar genes for DCAF8 using alignment to 12 protein entries:     DCAF8_HUMAN (see all proteins):
    PEX19    DCAF8L1    KIAA1651    DCAF8L2    FAM138C

    DCAF8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCAF8 (see all 851)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1388120171,2
    C--131541726(+) GCCCC-/TATCTT 3 -- ds50010--------
    rs1420612771,2
    --131541738(+) TGCTCG/TTCTGT 3 -- ds50010--------
    rs1131430731,2
    C--131541801(+) TGCAAA/C/GTAACT 3 -- ds50011CSA 1
    rs46562521,2
    C,F,H--131541900(+) GGGCTG/AGGAAA 3 -- ds500119Minor allele frequency- A:0.08NS EA NA 2362
    rs1921128581,2
    --131541956(+) ACTGAA/GCTAAA 3 -- ds50010--------
    rs1180143301,2
    C,F--131542150(+) CAGTCG/AGGAGA 3 -- ut31 nc-transcript-variant1Minor allele frequency- A:0.02EA 120
    rs1462603781,2
    C--131542172(+) ACTGGA/GAGAAA 3 -- ut31 nc-transcript-variant0--------
    rs591024011,2
    C--131542276(+) CCTCAG/AGGAGT 3 -- ut31 nc-transcript-variant3Minor allele frequency- A:0.03WA EA 240
    rs1849397091,2
    --131542324(+) GAAAAA/GGGGCA 3 -- ut31 nc-transcript-variant0--------
    rs2002277751,2
    --131542331(+) GGCAG-/GAG   
      GAAGAA
    GTATC
    3 -- cds1 nc-transcript-variant0--------

    HapMap Linkage Disequilibrium report for DCAF8 (160185505 - 160254920 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DCAF8:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664173CNV Deletion23128226
    nsv3210CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCAF8
    DNA2.0 Custom Variant and Variant Library Synthesis for DCAF8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    8 diseases for DCAF8:    
    About MalaCards
    neural tube defects    herpes simplex    tonsillitis    thyroiditis
    cerebritis    malaria    endotheliitis    prostatitis


    DCAF8 for disorders           About GeneDecksing


    Export disorders for DCAF8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCAF8 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with DCAF8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1, 2 Weimann M.... Stelzl U. (Nat. Methods 2013)
    2. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (Mol. Cell 2006)
    3. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PubMed id 16964240)1, 2 Angers S.... Zheng N. (Nature 2006)
    4. Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. (PubMed id 11401431)1, 3 Doudney K....Stanier P. (Genomics 2001)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    7. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    8. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    9. Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A). (PubMed id 22500989)1 Wu F....Zheng C. (FEBS Lett. 2012)
    10. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 50717 HGNC: 24891 AceView: WDR42A Ensembl:ENSG00000132716 euGenes: HUgn50717
    ECgene: DCAF8 H-InvDB: DCAF8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCAF8 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCAF8 gene:
    Search GeneIP for patents involving DCAF8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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