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Aliases for DCAF8 Gene

Aliases for DCAF8 Gene

  • DDB1 And CUL4 Associated Factor 8 2 3
  • WD Repeat-Containing Protein 42A 3 4
  • WD Repeat Domain 42A 2 3
  • WDR42A 3 4
  • H326 3 4
  • DDB1- And CUL4-Associated Factor 8 3
  • GAN2 3

External Ids for DCAF8 Gene

Previous HGNC Symbols for DCAF8 Gene

  • WDR42A

Previous GeneCards Identifiers for DCAF8 Gene

  • GC01M158453
  • GC01M160185
  • GC01M131542

Summaries for DCAF8 Gene

Entrez Gene Summary for DCAF8 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF8 Gene

DCAF8 (DDB1 And CUL4 Associated Factor 8) is a Protein Coding gene. Diseases associated with DCAF8 include giant axonal neuropathy 2, autosomal dominant and autosomal dominant charcot-marie-tooth disease type 2 with giant axons. An important paralog of this gene is DCAF8L1.

UniProtKB/Swiss-Prot for DCAF8 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF8 Gene

Genomics for DCAF8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAF8 Gene

Start:
160,215,715 bp from pter
End:
160,262,560 bp from pter
Size:
46,846 bases
Orientation:
Minus strand

Genomic View for DCAF8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF8 Gene

No data available for Regulatory Elements for DCAF8 Gene

Proteins for DCAF8 Gene

  • Protein details for DCAF8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5TAQ9-DCAF8_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 8
    Protein Accession:
    Q5TAQ9
    Secondary Accessions:
    • D3DVE6
    • Q12839
    • Q4QQI6
    • Q53F14
    • Q66K50
    • Q68CS7
    • Q96E00

    Protein attributes for DCAF8 Gene

    Size:
    597 amino acids
    Molecular mass:
    66852 Da
    Quaternary structure:
    • Interacts with DDB1, CUL4A and CUL4B. Interacts with KPNA1, KPNB1 and XPO1.
    SequenceCaution:
    • Sequence=AAA16607.1; Type=Frameshift; Positions=117, 123; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCAF8 Gene

    Alternative splice isoforms for DCAF8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF8 Gene

Proteomics data for DCAF8 Gene at MOPED

Post-translational modifications for DCAF8 Gene

  • Ubiquitination at Lys236, Lys363, and Lys438
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DCAF8 Gene

Domains for DCAF8 Gene

Gene Families for DCAF8 Gene

HGNC:
  • DCAF :DDB1 and CUL4 associated factors
  • WDR :WD repeat domain containing

Protein Domains for DCAF8 Gene

Suggested Antigen Peptide Sequences for DCAF8 Gene

Graphical View of Domain Structure for InterPro Entry

Q5TAQ9

UniProtKB/Swiss-Prot:

DCAF8_HUMAN :
  • Q5TAQ9
Family:
  • Belongs to the WD repeat DCAF8 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF8: view

Function for DCAF8 Gene

Molecular function for DCAF8 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DCAF8: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF8 Gene

Localization for DCAF8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF8 Gene

Nucleus. Cytoplasm. Note=It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent. {ECO:0000269 PubMed:22500989}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF8 Gene COMPARTMENTS Subcellular localization image for DCAF8 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 22500989
GO:0005737 cytoplasm IDA 22500989
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF8: view

Pathways for DCAF8 Gene

SuperPathways for DCAF8 Gene

No Data Available

UniProtKB/Swiss-Prot Q5TAQ9-DCAF8_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF8: view

No data available for Pathways by source for DCAF8 Gene

Transcripts for DCAF8 Gene

mRNA/cDNA for DCAF8 Gene

(17) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(18) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF8 Gene

DDB1 and CUL4 associated factor 8:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF8 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d · 3e · 3f ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g · 6h · 6i ^
SP1:
SP2:
SP3: - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - - - - - - -
SP8: - - - - -
SP9: - - - -
SP10: - - - - -
SP11: - - - - - -
SP12: - - - - - - -
SP13: - - - - -
SP14:
SP15: - - - - - - - - - - -
SP16: - - - - - - - - -
SP17: - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - - - -
SP20: - - - - -
SP21: - - - - - -
SP22: - - - - - -
SP23: -
SP24:
SP25:
SP26:
SP27: - -
SP28:
SP29: -

ExUns: 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17a · 17b · 17c ^ 18a · 18b ^ 19a · 19b ^ 20a · 20b
SP1: - - - - - - -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24: - -
SP25: -
SP26: - -
SP27:
SP28:
SP29:

Relevant External Links for DCAF8 Gene

GeneLoc Exon Structure for
DCAF8
ECgene alternative splicing isoforms for
DCAF8

Expression for DCAF8 Gene

mRNA expression in normal human tissues for DCAF8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DCAF8 Gene

This gene is overexpressed in Lung (15.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF8 Gene

SOURCE GeneReport for Unigene cluster for DCAF8 Gene Hs.632447

genes like me logo Genes that share expressions with DCAF8: view

Expression partners for DCAF8 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAF8 Gene

Orthologs for DCAF8 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCAF8 35
  • 94.08 (n)
  • 98.82 (a)
-- 36
  • 99 (a)
OneToMany
dog
(Canis familiaris)
Mammalia DCAF8 35
  • 93.29 (n)
  • 98.66 (a)
-- 36
  • 99 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dcaf8 35
  • 91.69 (n)
  • 96.78 (a)
Dcaf8 16
Dcaf8 36
  • 97 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia DCAF8 35
  • 99.78 (n)
  • 100 (a)
DCAF8 36
  • 100 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dcaf8 35
  • 92.16 (n)
  • 97.97 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves DCAF8 35
  • 79.31 (n)
  • 89.66 (a)
-- 36
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf8 35
  • 76.3 (n)
  • 84.2 (a)
Str.4021 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25402 35
zebrafish
(Danio rerio)
Actinopterygii LOC100007924 35
  • 65.07 (n)
  • 64.96 (a)
DCAF8 36
  • 63 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG8001 36
  • 29 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G45620 35
  • 48.48 (n)
  • 42 (a)
rice
(Oryza sativa)
Liliopsida Os03g0286800 35
  • 52.17 (n)
  • 46.05 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9303 36
  • 56 (a)
OneToMany
Species with no ortholog for DCAF8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF8 Gene

ENSEMBL:
Gene Tree for DCAF8 (if available)
TreeFam:
Gene Tree for DCAF8 (if available)

Paralogs for DCAF8 Gene

Paralogs for DCAF8 Gene

genes like me logo Genes that share paralogs with DCAF8: view

Variants for DCAF8 Gene

Sequence variations from dbSNP and Humsavar for DCAF8 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2696 -- 160,216,884(-) GAGGG(C/G)AGAAG utr-variant-3-prime, nc-transcript-variant
rs750936 -- 160,237,740(+) TTGCT(A/G)TATTG intron-variant
rs756311 -- 160,235,050(-) AATTA(A/T)TTTAT intron-variant
rs947492 -- 160,246,738(-) TCCCA(A/G)TGTGC intron-variant
rs947493 -- 160,246,404(-) CTTAC(C/T)TTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF8 Gene

Variant ID Type Subtype PubMed ID
esv2664173 CNV Deletion 23128226
nsv3210 CNV Loss 18451855

Relevant External Links for DCAF8 Gene

HapMap Linkage Disequilibrium report
DCAF8
Human Gene Mutation Database (HGMD)
DCAF8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF8 Gene

Disorders for DCAF8 Gene

UniProtKB/Swiss-Prot

DCAF8_HUMAN
  • Giant axonal neuropathy 2, autosomal dominant (GAN2) [MIM:610100]: An autosomal dominant peripheral axonal neuropathy characterized by onset of distal sensory impairment with lower extremity muscle weakness and atrophy after the second decade. Clinical features include foot deformities apparent in childhood, and cardiomyopathy in severely affected individuals. Sural nerve biopsy shows giant axonal swelling with neurofilament accumulation. {ECO:0000269 PubMed:24500646}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with DCAF8: view

No data available for OMIM , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DCAF8 Gene

Publications for DCAF8 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4
  2. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4
  3. Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. (PMID: 11401431) Doudney K. … Stanier P. (Genomics 2001) 2 3
  4. Characterization of nuclear import and export signals determining the subcellular localization of WD repeat-containing protein 42A (WDR42A). (PMID: 22500989) Wu F. … Zheng C. (FEBS Lett. 2012) 3 4
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 3 4

Products for DCAF8 Gene

Sources for DCAF8 Gene

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