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Aliases for DCAF7 Gene

Aliases for DCAF7 Gene

  • DDB1 And CUL4 Associated Factor 7 2 3 5
  • Seven-WD-Repeat Protein Of The AN11 Family-1 2 3
  • WD Repeat-Containing Protein An11 Homolog 3 4
  • WD Repeat-Containing Protein 68 3 4
  • Human Anthocyanin 2 3
  • WDR68 3 4
  • HAN11 3 4
  • WD Repeat Domain 68 2
  • SWAN-1 3
  • AN11 3

External Ids for DCAF7 Gene

Previous HGNC Symbols for DCAF7 Gene

  • WDR68

Previous GeneCards Identifiers for DCAF7 Gene

  • GC17P058983
  • GC17P061627
  • GC17P056994

Summaries for DCAF7 Gene

Entrez Gene Summary for DCAF7 Gene

  • This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for DCAF7 Gene

DCAF7 (DDB1 And CUL4 Associated Factor 7) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Chaperonin-mediated protein folding.

UniProtKB/Swiss-Prot for DCAF7 Gene

  • Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Wiki entry for DCAF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF7 Gene

Genomics for DCAF7 Gene

Regulatory Elements for DCAF7 Gene

Promoters for DCAF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCAF7 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCAF7 Gene

Chromosome:
17
Start:
63,550,435 bp from pter
End:
63,594,279 bp from pter
Size:
43,845 bases
Orientation:
Plus strand

Genomic View for DCAF7 Gene

Genes around DCAF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF7 Gene

Proteins for DCAF7 Gene

  • Protein details for DCAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61962-DCAF7_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 7
    Protein Accession:
    P61962
    Secondary Accessions:
    • B4E039
    • D3DU14
    • O15491
    • Q9DAE4

    Protein attributes for DCAF7 Gene

    Size:
    342 amino acids
    Molecular mass:
    38926 Da
    Quaternary structure:
    • Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703. Interacts with human adenovirus 5 E1A protein (PubMed:23864635).

    Alternative splice isoforms for DCAF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF7 Gene

Proteomics data for DCAF7 Gene at MOPED

Post-translational modifications for DCAF7 Gene

  • Ubiquitination at Lys 30, Lys 73, Lys 81, and Lys 167
  • Modification sites at PhosphoSitePlus

Other Protein References for DCAF7 Gene

No data available for DME Specific Peptides for DCAF7 Gene

Domains & Families for DCAF7 Gene

Protein Domains for DCAF7 Gene

Suggested Antigen Peptide Sequences for DCAF7 Gene

Graphical View of Domain Structure for InterPro Entry

P61962

UniProtKB/Swiss-Prot:

DCAF7_HUMAN :
  • Belongs to the WD repeat DCAF7 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat DCAF7 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF7: view

Function for DCAF7 Gene

Molecular function for DCAF7 Gene

UniProtKB/Swiss-Prot Function:
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes for DCAF7 Gene

genes like me logo Genes that share phenotypes with DCAF7: view

Animal Model Products

miRNA for DCAF7 Gene

miRTarBase miRNAs that target DCAF7

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF7 Gene

Localization for DCAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF7 Gene

Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF7 Gene COMPARTMENTS Subcellular localization image for DCAF7 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0016363 nuclear matrix IDA 21328542
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF7: view

Pathways & Interactions for DCAF7 Gene

genes like me logo Genes that share pathways with DCAF7: view

UniProtKB/Swiss-Prot P61962-DCAF7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF7 Gene

None

No data available for SIGNOR curated interactions for DCAF7 Gene

Drugs & Compounds for DCAF7 Gene

(1) Additional Compounds for DCAF7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DCAF7: view

Transcripts for DCAF7 Gene

mRNA/cDNA for DCAF7 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF7 Gene

DDB1 and CUL4 associated factor 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF7 Gene

No ASD Table

Relevant External Links for DCAF7 Gene

GeneLoc Exon Structure for
DCAF7
ECgene alternative splicing isoforms for
DCAF7

Expression for DCAF7 Gene

mRNA expression in normal human tissues for DCAF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCAF7 Gene

This gene is overexpressed in Bone (17.9), Peripheral blood mononuclear cells (9.2), and Breast (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DCAF7 Gene



SOURCE GeneReport for Unigene cluster for DCAF7 Gene Hs.410596

genes like me logo Genes that share expression patterns with DCAF7: view

Protein tissue co-expression partners for DCAF7 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAF7 Gene

Orthologs for DCAF7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCAF7 35
  • 92.69 (n)
  • 100 (a)
WDR68 36
  • 42 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF7 35
  • 93.86 (n)
  • 100 (a)
DCAF7 36
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf7 35
  • 92.01 (n)
  • 100 (a)
Dcaf7 16
Dcaf7 36
  • 42 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCAF7 35
  • 99.61 (n)
  • 100 (a)
DCAF7 36
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf7 35
  • 92.4 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia DCAF7 36
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF7 35
  • 87.04 (n)
  • 100 (a)
DCAF7 36
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF7 36
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf7 35
  • 82.36 (n)
  • 99.71 (a)
MGC75622 35
African clawed frog
(Xenopus laevis)
Amphibia cg14614-prov 35
zebrafish
(Danio rerio)
Actinopterygii dcaf7 35
  • 82.55 (n)
  • 97.95 (a)
wufj83g06 35
dcaf7 36
  • 42 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11031 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000678 35
  • 72.98 (n)
  • 86.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14614 35
  • 72.06 (n)
  • 86.18 (a)
CG14614 36
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea swan-2 35
  • 60.9 (n)
  • 64.48 (a)
swan-1 36
  • 20 (a)
OneToMany
swan-2 36
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 8 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ATAN11 35
  • 61.59 (n)
  • 62.73 (a)
soybean
(Glycine max)
eudicotyledons Gma.16640 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9226 35
rice
(Oryza sativa)
Liliopsida Os.10953 35
Os02g0524600 35
  • 61.7 (n)
  • 62.73 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6823 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5071 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4534 36
  • 36 (a)
OneToOne
Species with no ortholog for DCAF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DCAF7 Gene

ENSEMBL:
Gene Tree for DCAF7 (if available)
TreeFam:
Gene Tree for DCAF7 (if available)

Paralogs for DCAF7 Gene

No data available for Paralogs for DCAF7 Gene

Variants for DCAF7 Gene

Sequence variations from dbSNP and Humsavar for DCAF7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs14608 -- 63,594,174(-) AATTA(A/G)GTTTA intron-variant, utr-variant-3-prime
rs2413 -- 63,594,162(+) TTTAC(A/C/G/T)TAGGA intron-variant, utr-variant-3-prime
rs1060593 -- 63,581,795(+) GCACC(A/T)TTCTA intron-variant
rs1136324 -- 63,592,322(+) ATGGC(A/G)TGAAC intron-variant, utr-variant-3-prime
rs3817183 -- 63,579,535(+) TAGAA(A/C/T)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF7 Gene

Variant ID Type Subtype PubMed ID
nsv908683 CNV Loss 21882294

Variation tolerance for DCAF7 Gene

Gene Damage Index Score: 0.04; 0.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF7 Gene

HapMap Linkage Disequilibrium report
DCAF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF7 Gene

Disorders for DCAF7 Gene

Relevant External Links for DCAF7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF7

No disorders were found for DCAF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF7 Gene

Publications for DCAF7 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 3 4 67
  2. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. (PMID: 20940704) Ritterhoff S. … Schmitz M.L. (EMBO J. 2010) 2 3
  3. HAN11 binds mDia1 and controls GLI1 transcriptional activity. (PMID: 16887337) Morita K. … Watt F.M. (J. Dermatol. Sci. 2006) 3 23
  4. The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals. (PMID: 9192870) de Vetten N. … Koes R. (Genes Dev. 1997) 2 3
  5. Ski regulates Hippo and TAZ signaling to suppress breast cancer progression. (PMID: 25670202) Rashidian J. … Luo K. (Sci Signal 2015) 3

Products for DCAF7 Gene

Sources for DCAF7 Gene

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