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Aliases for DCAF7 Gene

Aliases for DCAF7 Gene

  • DDB1 And CUL4 Associated Factor 7 2 3 5
  • Seven-WD-Repeat Protein Of The AN11 Family-1 2 3
  • WD Repeat-Containing Protein An11 Homolog 3 4
  • WD Repeat-Containing Protein 68 3 4
  • Human Anthocyanin 2 3
  • WDR68 3 4
  • HAN11 3 4
  • DDB1- And CUL4-Associated Factor 7 3
  • WD Repeat Domain 68 2
  • SWAN-1 3
  • AN11 3

External Ids for DCAF7 Gene

Previous HGNC Symbols for DCAF7 Gene

  • WDR68

Previous GeneCards Identifiers for DCAF7 Gene

  • GC17P058983
  • GC17P061627
  • GC17P056994

Summaries for DCAF7 Gene

Entrez Gene Summary for DCAF7 Gene

  • This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for DCAF7 Gene

DCAF7 (DDB1 And CUL4 Associated Factor 7) is a Protein Coding gene. Among its related pathways are Chaperonin-mediated protein folding and Metabolism of proteins.

UniProtKB/Swiss-Prot for DCAF7 Gene

  • Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Wiki entry for DCAF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF7 Gene

Genomics for DCAF7 Gene

Regulatory Elements for DCAF7 Gene

Enhancers for DCAF7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F063517 1.4 Ensembl ENCODE 12 -33.2 -33151 0.5 ELF3 ARID4B THRB ZNF48 ZSCAN9 RAD21 RARA GLIS2 ETV6 FOS DCAF7 ACE LOC342541 CYB561 RNU6-288P KCNH6 ACE3P
GH17F063571 1.1 Ensembl ENCODE 11.9 +21.7 21661 1.0 SIX4 ATF1 TAL1 JUN ZMYM3 ZBTB40 ZNF664 GATA3 GATA2 RCOR1 DCAF7 TACO1 CYB561 GC17M063565 GC17M063574 RNU6-288P
GH17F063579 0.6 ENCODE 11.6 +29.5 29464 1.2 HDGF ELF3 MLX ZFP64 ARID4B DMAP1 THRB ZNF48 RAD21 RARA TACO1 DCAF7 CYB561 ACE LOC342541 GC17M063574 RNU6-288P PIR51747
GH17F063484 0.6 ENCODE 11.3 -65.6 -65551 0.1 CTCF MAZ ZNF687 NFYB RAD21 CYB561 DCAF7 TACO1 ENSG00000264813 ACE3P
GH17F063600 0.6 ENCODE 11.2 +50.8 50842 2.5 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC POLG2 DDX42 CEP95 MAP3K3 CSH2 ENSG00000263501 ENSG00000259333 LOC100419888 TRMT112P3 LOC101927877
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DCAF7 on UCSC Golden Path with GeneCards custom track

Promoters for DCAF7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001350932 465 3001 PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for DCAF7 Gene

Chromosome:
17
Start:
63,550,435 bp from pter
End:
63,594,279 bp from pter
Size:
43,845 bases
Orientation:
Plus strand

Genomic View for DCAF7 Gene

Genes around DCAF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF7 Gene

Proteins for DCAF7 Gene

  • Protein details for DCAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61962-DCAF7_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 7
    Protein Accession:
    P61962
    Secondary Accessions:
    • B4E039
    • D3DU14
    • O15491
    • Q9DAE4

    Protein attributes for DCAF7 Gene

    Size:
    342 amino acids
    Molecular mass:
    38926 Da
    Quaternary structure:
    • Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703. Interacts with human adenovirus 5 E1A protein (PubMed:23864635).

    Alternative splice isoforms for DCAF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF7 Gene

Post-translational modifications for DCAF7 Gene

  • Ubiquitination at Lys 30, Lys 73, Lys 81, and Lys 167
  • Modification sites at PhosphoSitePlus

Other Protein References for DCAF7 Gene

No data available for DME Specific Peptides for DCAF7 Gene

Domains & Families for DCAF7 Gene

Protein Domains for DCAF7 Gene

Suggested Antigen Peptide Sequences for DCAF7 Gene

Graphical View of Domain Structure for InterPro Entry

P61962

UniProtKB/Swiss-Prot:

DCAF7_HUMAN :
  • Belongs to the WD repeat DCAF7 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat DCAF7 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF7: view

Function for DCAF7 Gene

Molecular function for DCAF7 Gene

UniProtKB/Swiss-Prot Function:
Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14593110
genes like me logo Genes that share ontologies with DCAF7: view
genes like me logo Genes that share phenotypes with DCAF7: view

Animal Model Products

miRNA for DCAF7 Gene

miRTarBase miRNAs that target DCAF7

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF7 Gene

Localization for DCAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF7 Gene

Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF7 Gene COMPARTMENTS Subcellular localization image for DCAF7 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,TAS 9192870
GO:0016363 nuclear matrix IDA 21328542
GO:0043234 protein complex IDA 21328542
genes like me logo Genes that share ontologies with DCAF7: view

Pathways & Interactions for DCAF7 Gene

genes like me logo Genes that share pathways with DCAF7: view

UniProtKB/Swiss-Prot P61962-DCAF7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF7: view

No data available for SIGNOR curated interactions for DCAF7 Gene

Drugs & Compounds for DCAF7 Gene

(1) Additional Compounds for DCAF7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DCAF7: view

Transcripts for DCAF7 Gene

mRNA/cDNA for DCAF7 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF7 Gene

DDB1 and CUL4 associated factor 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF7 Gene

No ASD Table

Relevant External Links for DCAF7 Gene

GeneLoc Exon Structure for
DCAF7
ECgene alternative splicing isoforms for
DCAF7

Expression for DCAF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCAF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCAF7 Gene

This gene is overexpressed in Bone (17.9), Peripheral blood mononuclear cells (9.2), and Breast (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DCAF7 Gene



Protein tissue co-expression partners for DCAF7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAF7 Gene:

DCAF7

SOURCE GeneReport for Unigene cluster for DCAF7 Gene:

Hs.410596
genes like me logo Genes that share expression patterns with DCAF7: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAF7 Gene

Orthologs for DCAF7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF7 34 35
  • 99.61 (n)
dog
(Canis familiaris)
Mammalia DCAF7 34 35
  • 93.86 (n)
cow
(Bos Taurus)
Mammalia DCAF7 34
  • 92.69 (n)
WDR68 35
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf7 34
  • 92.4 (n)
mouse
(Mus musculus)
Mammalia Dcaf7 34 16 35
  • 92.01 (n)
oppossum
(Monodelphis domestica)
Mammalia DCAF7 35
  • 42 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF7 34 35
  • 87.04 (n)
lizard
(Anolis carolinensis)
Reptilia DCAF7 35
  • 42 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf7 34
  • 82.36 (n)
MGC75622 34
African clawed frog
(Xenopus laevis)
Amphibia cg14614-prov 34
zebrafish
(Danio rerio)
Actinopterygii dcaf7 34 35
  • 82.55 (n)
wufj83g06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11031 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000678 34
  • 72.98 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14614 34 35
  • 72.06 (n)
worm
(Caenorhabditis elegans)
Secernentea swan-2 34 35
  • 60.9 (n)
swan-1 35
  • 20 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 8 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ATAN11 34
  • 61.59 (n)
soybean
(Glycine max)
eudicotyledons Gma.16640 34
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9226 34
rice
(Oryza sativa)
Liliopsida Os02g0524600 34
  • 61.7 (n)
Os.10953 34
wheat
(Triticum aestivum)
Liliopsida Ta.6823 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4534 35
  • 36 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5071 34
Species where no ortholog for DCAF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DCAF7 Gene

ENSEMBL:
Gene Tree for DCAF7 (if available)
TreeFam:
Gene Tree for DCAF7 (if available)

Paralogs for DCAF7 Gene

No data available for Paralogs for DCAF7 Gene

Variants for DCAF7 Gene

Sequence variations from dbSNP and Humsavar for DCAF7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs10546974 -- 63,559,337(+) TACAT(-/AC)ATATA intron-variant
rs1060593 -- 63,581,795(+) GCACC(A/T)TTCTA intron-variant
rs10637227 -- 63,559,377(+) ATGTG(-/TA)TATAT intron-variant
rs10637228 -- 63,559,399(+) ATATG(-/TA)TATAT intron-variant
rs10643199 -- 63,559,439(+) GTGTG(-/TA)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF7 Gene

Variant ID Type Subtype PubMed ID
nsv1134665 CNV deletion 24896259
nsv952355 CNV deletion 24416366

Variation tolerance for DCAF7 Gene

Gene Damage Index Score: 0.04; 0.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF7 Gene

Disorders for DCAF7 Gene

Relevant External Links for DCAF7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF7

No disorders were found for DCAF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF7 Gene

Publications for DCAF7 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 3 4 64
  2. HAN11 binds mDia1 and controls GLI1 transcriptional activity. (PMID: 16887337) Morita K. … Watt F.M. (J. Dermatol. Sci. 2006) 3 4 22 64
  3. The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals. (PMID: 9192870) de Vetten N. … Koes R. (Genes Dev. 1997) 2 3 4 64
  4. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. (PMID: 21328542) Sircoulomb F. … Ginestier C. (EMBO Mol. Med. 2011) 3 4 64
  5. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. (PMID: 20940704) Ritterhoff S. … Schmitz M.L. (EMBO J. 2010) 2 3 64

Products for DCAF7 Gene

Sources for DCAF7 Gene

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