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Aliases for DCAF7 Gene

Aliases for DCAF7 Gene

  • DDB1 And CUL4 Associated Factor 7 2 3
  • Seven-WD-Repeat Protein Of The AN11 Family-1 2 3
  • WD Repeat-Containing Protein An11 Homolog 3 4
  • WD Repeat-Containing Protein 68 3 4
  • Human Anthocyanin 2 3
  • WDR68 3 4
  • HAN11 3 4
  • DDB1- And CUL4-Associated Factor 7 3
  • WD Repeat Domain 68 2
  • SWAN-1 3
  • AN11 3

External Ids for DCAF7 Gene

Previous Symbols for DCAF7 Gene

  • WDR68

Summaries for DCAF7 Gene

Entrez Gene Summary for DCAF7 Gene

  • This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants, fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

GeneCards Summary for DCAF7 Gene

DCAF7 (DDB1 And CUL4 Associated Factor 7) is a Protein Coding gene. Among its related pathways are TNF-alpha/NF-kB Signaling Pathway.

UniProtKB/Swiss-Prot for DCAF7 Gene

  • Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Wiki entry for DCAF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF7 Gene

Genomics for DCAF7 Gene

Genomic Location for DCAF7 Gene

Start:
63,550,435 bp from pter
End:
63,594,279 bp from pter
Size:
43,845 bases
Orientation:
Plus strand

Genomic View for DCAF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF7 Gene

No data available for Regulatory Elements for DCAF7 Gene

Proteins for DCAF7 Gene

  • Protein details for DCAF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61962-DCAF7_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 7
    Protein Accession:
    P61962
    Secondary Accessions:
    • B4E039
    • D3DU14
    • O15491
    • Q9DAE4

    Protein attributes for DCAF7 Gene

    Size:
    342 amino acids
    Molecular mass:
    38926 Da
    Quaternary structure:
    • Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703.

    Alternative splice isoforms for DCAF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF7 Gene

Proteomics data for DCAF7 Gene at MOPED

Post-translational modifications for DCAF7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys30, Lys73, Lys81, and Lys167

Other Protein References for DCAF7 Gene

No data available for DME Specific Peptides for DCAF7 Gene

Domains for DCAF7 Gene

Gene Families for DCAF7 Gene

HGNC:
  • WDR :WD repeat domain containing
  • DCAF :DDB1 and CUL4 associated factors

Protein Domains for DCAF7 Gene

UniProtKB/Swiss-Prot:

DCAF7_HUMAN
Family:
  • Belongs to the WD repeat DCAF7 family.:
    • P61962
Similarity:
  • Contains 7 WD repeats.:
    • P61962
genes like me logo Genes that share domains with DCAF7: view

Function for DCAF7 Gene

Molecular function for DCAF7 Gene

UniProtKB/Swiss-Prot Function: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 14593110
genes like me logo Genes that share ontologies with DCAF7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF7 Gene

Localization for DCAF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF7 Gene

Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF7 Gene COMPARTMENTS Subcellular localization image for DCAF7 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm TAS 9192870
GO:0016363 nuclear matrix IDA 21328542
GO:0043234 protein complex IDA 21328542
genes like me logo Genes that share ontologies with DCAF7: view

Pathways for DCAF7 Gene

genes like me logo Genes that share pathways with DCAF7: view

Pathways by source for DCAF7 Gene

1 BioSystems pathway for DCAF7 Gene

UniProtKB/Swiss-Prot P61962-DCAF7_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF7: view

Compounds for DCAF7 Gene

(1) Novoseek inferred chemical compound relationships for DCAF7 Gene

Compound -log(P) Hits PubMed IDs
mdv 1 85.5 1
genes like me logo Genes that share compounds with DCAF7: view

Transcripts for DCAF7 Gene

mRNA/cDNA for DCAF7 Gene

(2) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF7 Gene

DDB1 and CUL4 associated factor 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF7 Gene

No ASD Table

Relevant External Links for DCAF7 Gene

GeneLoc Exon Structure for
DCAF7
ECgene alternative splicing isoforms for
DCAF7

Expression for DCAF7 Gene

mRNA expression in normal human tissues for DCAF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DCAF7 Gene

SOURCE GeneReport for Unigene cluster for DCAF7 Gene Hs.410596

genes like me logo Genes that share expressions with DCAF7: view

Orthologs for DCAF7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF7 36
  • 99.61 (n)
  • 100 (a)
DCAF7 37
  • 42 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCAF7 36
  • 92.69 (n)
  • 100 (a)
WDR68 37
  • 42 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF7 36
  • 93.86 (n)
  • 100 (a)
DCAF7 37
  • 42 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf7 36
  • 92.01 (n)
  • 100 (a)
Dcaf7 16
Dcaf7 37
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAF7 37
  • 42 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf7 36
  • 92.4 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves DCAF7 36
  • 87.04 (n)
  • 100 (a)
DCAF7 37
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF7 37
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia cg14614-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf7 36
  • 82.36 (n)
  • 99.71 (a)
MGC75622 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11031 36
zebrafish
(Danio rerio)
Actinopterygii dcaf7 36
  • 82.55 (n)
  • 97.95 (a)
dcaf7 37
  • 42 (a)
OneToOne
wufj83g06 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000678 36
  • 72.98 (n)
  • 86.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14614 36
  • 72.06 (n)
  • 86.18 (a)
CG14614 37
  • 36 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea swan-1 37
  • 20 (a)
OneToMany
swan-2 36
  • 60.9 (n)
  • 64.48 (a)
swan-2 37
  • 18 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 8 (a)
OneToOne
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.9226 36
soybean
(Glycine max)
eudicotyledons Gma.16640 36
thale cress
(Arabidopsis thaliana)
eudicotyledons ATAN11 36
  • 61.59 (n)
  • 62.73 (a)
rice
(Oryza sativa)
Liliopsida Os.10953 36
Os02g0524600 36
  • 61.7 (n)
  • 62.73 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6823 36
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5071 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4534 37
  • 36 (a)
OneToOne
Species with no ortholog for DCAF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DCAF7 Gene

ENSEMBL:
Gene Tree for DCAF7 (if available)
TreeFam:
Gene Tree for DCAF7 (if available)

Paralogs for DCAF7 Gene

No data available for Paralogs for DCAF7 Gene

Variants for DCAF7 Gene

Sequence variations from dbSNP and Humsavar for DCAF7 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2413 -- 63,594,162(-) TTTAC(G/T)TAGGA utr-variant-3-prime, intron-variant
rs14608 -- 63,594,174(-) AATTA(A/G)GTTTA utr-variant-3-prime, intron-variant
rs1060593 -- 63,581,795(+) GCACC(A/T)TTCTA intron-variant
rs1136324 -- 63,592,322(+) ATGGC(A/G)TGAAC utr-variant-3-prime, intron-variant
rs2292422 -- 63,585,249(+) CCTGT(C/T)GCCAG reference, synonymous-codon, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF7 Gene

Variant ID Type Subtype PubMed ID
nsv908683 CNV Loss 21882294

Relevant External Links for DCAF7 Gene

HapMap Linkage Disequilibrium report
DCAF7

Disorders for DCAF7 Gene

No disorders were found for DCAF7 Gene.

No data available for UniProtKB/Swiss-Prot for DCAF7 Gene

Publications for DCAF7 Gene

  1. HAN11 binds mDia1 and controls GLI1 transcriptional activity. (PMID: 16887337) Morita K. … Watt F.M. (J. Dermatol. Sci. 2006) 3 4 23
  2. The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals. (PMID: 9192870) de Vetten N. … Koes R. (Genes Dev. 1997) 2 3 4
  3. Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. (PMID: 14593110) Skurat A.V. … Dietrich A.D. (J. Biol. Chem. 2004) 3 4
  4. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4
  5. ZNF703 gene amplification at 8p12 specifies luminal B breast cancer. (PMID: 21328542) Sircoulomb F. … Ginestier C. (EMBO Mol. Med. 2011) 3 4

Products for DCAF7 Gene

Sources for DCAF7 Gene

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