Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DCAF7 Gene

protein-coding   GIFtS: 52
GCID: GC17P061627

DDB1 And CUL4 Associated Factor 7

(Previous name: WD repeat domain 68)
(Previous symbol: WDR68)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DDB1 And CUL4 Associated Factor 71 2     WD Repeat-Containing Protein An11 Homolog2 3
WDR681 2 3     WD Repeat Domain 681
Human Anthocyanin1 2     AN112
Seven-WD-Repeat Protein Of The AN11 Family-11 2     SWAN-12
HAN112 3     DDB1- And CUL4-Associated Factor 72
WD Repeat-Containing Protein 682 3     

External Ids:    HGNC: 309151   Entrez Gene: 102382   Ensembl: ENSG000001364857   OMIM: 6059735   UniProtKB: P619623   

Export aliases for DCAF7 gene to outside databases

Previous GC identifers: GC17P058983 GC17P056994


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DCAF7 Gene:
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby
enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for
protein complexes involved in kinase signaling. This highly conserved gene is present in eukaryotic plants,
fungi, and animals. The ortholog of this gene was first identified in plants as a key regulator of anthocyanin
biosynthesis and flower pigmentation. Alternative splicing results in multiple transcript variants. (provided by
RefSeq, Feb 2014)

GeneCards Summary for DCAF7 Gene:
DCAF7 (DDB1 and CUL4 associated factor 7) is a protein-coding gene. Diseases associated with DCAF7 include campomelic dysplasia, and epidermodysplasia verruciformis.

UniProtKB/Swiss-Prot: DCAF7_HUMAN, P61962
Function: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of
the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the
first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could
be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3
ubiquitin-protein ligase complex

Gene Wiki entry for DCAF7 (WDR68) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DCAF7
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCAF7 promoter sequence
   Search Chromatin IP Primers for DCAF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCAF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q23.3   Ensembl cytogenetic band:  17q23.3   HGNC cytogenetic band: 17q23.3

DCAF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF7 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P061627:  view genomic region     (about GC identifiers)

Start:
61,627,822 bp from pter      End:
61,671,641 bp from pter
Size:
43,820 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DCAF7_HUMAN, P61962 (See protein sequence)
Recommended Name: DDB1- and CUL4-associated factor 7  
Size: 342 amino acids; 38926 Da
Subunit: Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703
Secondary accessions: D3DU14 O15491 Q9DAE4

Explore the universe of human proteins at neXtProt for DCAF7: NX_P61962

Explore proteomics data for DCAF7 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys30, Lys73, Lys81, Lys167
  • Modification sites at PhosphoSitePlus

  • See DCAF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005819.3  
    ENSEMBL proteins: 
     ENSP00000403920   ENSP00000402312   ENSP00000308344  

    DCAF7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DCAF7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DCAF7
    GenScript Custom Purified and Recombinant Proteins Services for DCAF7
    Novus Biologicals DCAF7 Proteins
    Novus Biologicals DCAF7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DCAF7
    Cloud-Clone Corp. Proteins for DCAF7

    DCAF7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DCAF7
    Novus Biologicals DCAF7 Antibodies
    Abcam antibodies for DCAF7
    Cloud-Clone Corp. Antibodies for DCAF7
    Search ThermoFisher Antibodies for DCAF7
    LSBio Antibodies in human, mouse, rat for DCAF7

    DCAF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DCAF7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DCAF7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCAF7
    Cloud-Clone Corp. CLIAs for DCAF7


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry P61962

    ProtoNet protein and cluster: P61962

    UniProtKB/Swiss-Prot: DCAF7_HUMAN, P61962
    Similarity: Belongs to the WD repeat DCAF7 family
    Similarity: Contains 4 WD repeats


    DCAF7 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCAF7_HUMAN, P61962
    Function: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of
    the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the
    first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could
    be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3
    ubiquitin-protein ligase complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI14593110
         
    DCAF7 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCAF7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCAF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCAF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCAF7

    miRNA
    Products:
        
    miRTarBase miRNAs that target DCAF7:
    hsa-mir-326 (MIRT043645), hsa-mir-155-5p (MIRT005255), hsa-mir-18a-5p (MIRT050673), hsa-mir-7-5p (MIRT025855), hsa-mir-193b-3p (MIRT016519), hsa-mir-222-3p (MIRT046679), hsa-mir-1229-3p (MIRT036382), hsa-mir-760 (MIRT036725), hsa-let-7b-5p (MIRT051938), hsa-mir-16-5p (MIRT031778), hsa-let-7c-5p (MIRT051762), hsa-mir-26a-5p (MIRT050075), hsa-mir-19b-3p (MIRT031255)

    Block miRNA regulation of human, mouse, rat DCAF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF7 (see all 136):
    hsa-miR-194* hsa-miR-193a-3p hsa-miR-128 hsa-miR-1260b hsa-miR-519a hsa-miR-3622b-3p hsa-miR-200b hsa-miR-520b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DCAF7
    Predesigned siRNA for gene silencing in human, mouse, rat DCAF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DCAF7

    Clone
    Products:
         
    OriGene clones in human, mouse for DCAF7 (see all 6)
    OriGene ORF clones in mouse, rat for DCAF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCAF7 (NM_005828)
    Sino Biological Human cDNA Clone for DCAF7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCAF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DCAF7
    Browse ESI BIO Cell Lines and PureStem Progenitors for DCAF7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DCAF7_HUMAN, P61962: Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from
    the nucleus to cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3
    extracellular1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm TAS9192870
    GO:0016363nuclear matrix IDA--
    GO:0043234protein complex IDA--

    DCAF7 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DCAF7 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    1 BioSystems Pathway for DCAF7
        TNF-alpha/NF-kB Signaling Pathway



    UniProtKB/Swiss-Prot: DCAF7_HUMAN, P61962
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCAF7
    Interactions:

        GeneGlobe Interaction Network for DCAF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCAF7 (P619621, 2, 3 ENSP000003083444) via UniProtKB, MINT, STRING, and/or I2D (see all 72)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIPK2Q9H2X61, 2, 3EBI-359808,EBI-348345 MINT-8084976 MINT-8085254 MINT-8085171 MINT-8088896 MINT-8085240 MINT-8085226 MINT-8084962 MINT-8084992 MINT-8084886 MINT-8084902 MINT-8085008 I2D: score=1 
    MAP3K1Q132331, 2, 3, ENSP000003824234EBI-359808,EBI-49776 MINT-8085204 MINT-8085171 MINT-8088896 MINT-8085134 MINT-48280 MINT-8085187 MINT-47978 MINT-8085083 I2D: score=3 STRING: ENSP00000382423
    DYRK1AQ136271, 2, 3, ENSP000003819324EBI-359808,EBI-1053596 MINT-8085026 MINT-8085104 MINT-8085187 I2D: score=2 STRING: ENSP00000381932
    YWHAGP619812, 3, ENSP000003063304MINT-50816 I2D: score=3 STRING: ENSP00000306330
    SFNP319472, 3MINT-3976171 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0016567protein ubiquitination IEA--

    DCAF7 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCAF7

    1 Novoseek inferred chemical compound relationship for DCAF7 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mdv 1 85.5 1 16272155 (1)



    DCAF7 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DCAF7 gene (2 alternative transcripts): 
    NM_005828.4  NM_001003725.1  

    Unigene Cluster for DCAF7:

    DDB1 and CUL4 associated factor 7
    Hs.410596  [show with all ESTs]
    Unigene Representative Sequence: NM_005828
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000577702(uc002jbb.3) ENST00000582103 ENST00000415273 ENST00000582274
    ENST00000585252 ENST00000580091 ENST00000431926 ENST00000310827(uc002jbc.3 uc010wpn.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DCAF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF7 (see all 136):
    hsa-miR-194* hsa-miR-193a-3p hsa-miR-128 hsa-miR-1260b hsa-miR-519a hsa-miR-3622b-3p hsa-miR-200b hsa-miR-520b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DCAF7
    Predesigned siRNA for gene silencing in human, mouse, rat DCAF7
    Clone
    Products:
         
    OriGene clones in human, mouse for DCAF7 (see all 6)
    OriGene ORF clones in mouse, rat for DCAF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DCAF7 (NM_005828)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCAF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DCAF7
    OriGene qSTAR qPCR primer pairs in human, mouse for DCAF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCAF7
      QuantiTect SYBR Green Assays in human, mouse, rat DCAF7
      QuantiFast Probe-based Assays in human, mouse, rat DCAF7

    Additional mRNA sequence: 

    AK025925.1 AK026008.1 AK294925.1 AK303212.1 AL832440.1 BC024682.1 BC027489.1 BX648608.1 
    NR_073585.1 U94747.1 

    18 DOTS entries:

    DT.100815195  DT.91885918  DT.95356936  DT.100815191  DT.75190975  DT.95356919  DT.100815185  DT.75134367 
    DT.100815188  DT.120993088  DT.100815182  DT.101963255  DT.91888139  DT.92001378  DT.95258584  DT.120992980 
    DT.40263021  DT.95073172 

    11 AceView cDNA sequences:

    AA769995 AA719279 AW204667 AA770084 AA770023 H49384 BM992733 AK130672 
    AA658438 H49195 AW975100 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DCAF7 expression in normal human tissues (normalized intensities)      DCAF7 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCACCTGAA
    DCAF7 Expression
    About this image


    DCAF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    DCAF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCAF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.410596
        Custom PCR Arrays for DCAF7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DCAF7
    OriGene qSTAR qPCR primer pairs in human, mouse for DCAF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCAF7
    QuantiTect SYBR Green Assays in human, mouse, rat DCAF7
    QuantiFast Probe-based Assays in human, mouse, rat DCAF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCAF7 gene from Selected species (see all 24)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcaf71 , 5 DDB1 and CUL4 associated factor 71, 5 92.01(n)1
    100(a)1
      11 (68.89 cM)5
    718331  NM_027946.31  NP_082222.11 
     1060368725 
    chicken
    (Gallus gallus)
    Aves DCAF71 DDB1 and CUL4 associated factor 7 87.04(n)
    100(a)
      771554  NM_001079504.1  NP_001072972.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCAF76
    DDB1 and CUL4 associated factor 7
    42(a)
    1 ↔ 1
    6(60958040-60973446)
    African clawed frog
    (Xenopus laevis)
    Amphibia cg14614-prov2 WD-repeat protein 82.47(n)    BC044040.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj83g062 wufj83g06 82.77(n)   337565  BC053157.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG146141 CG14614 72.06(n)
    86.18(a)
      33131  NM_134617.4  NP_608461.1 
    worm
    (Caenorhabditis elegans)
    Secernentea swan-21 swan-2 60.9(n)
    64.48(a)
      179875  NM_074016.5  NP_506417.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YPL247C)4 Putative protein of unknown function; green fluorescent more   --   16(84196-82625) 855829  NP_015077.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATAN111 ATAN11 61.59(n)
    62.73(a)
      837849  NM_101162.3  NP_172751.1 
    rice
    (Oryza sativa)
    Liliopsida Os.109532 Transcribed sequence with moderate similarity to protein more 76.56(n)    CB659317.1 


    ENSEMBL Gene Tree for DCAF7 (if available)
    TreeFam Gene Tree for DCAF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DCAF7 (see all 919)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs750239671,2
    C,F--56992273(+) GCACCA/GCCACC 2 -- us2k11Minor allele frequency- G:0.07WA 118
    rs784163721,2
    F--56992433(+) TCTAAT/CAAAAA 2 -- us2k11Minor allele frequency- C:0.12WA 118
    rs353382341,2
    C,H--56992481(+) AATTTC/TCTCCC 2 -- us2k12Minor allele frequency- T:0.01NS NA 172
    rs1875068031,2
    --56992484(+) TTCCTA/CCCCCC 2 -- us2k10--------
    rs1433250311,2
    --56992527(+) ATTTTG/TTATTA 2 -- us2k10--------
    rs1924238321,2
    --56992644(+) CGGGCA/GCCTGT 2 -- us2k10--------
    rs1833738261,2
    --56992777(+) AAAATA/CAAATA 2 -- us2k10--------
    rs1888515021,2
    --56992788(+) AAATTA/TAAAAA 2 -- us2k10--------
    rs1124425091,2
    C,F--56992816(+) CCAGAT/AGCGGT 2 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1925887731,2
    --56992839(+) TAATCA/CCAACA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCAF7 (61627822 - 61671641 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DCAF7:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv908683CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCAF7
    DNA2.0 Custom Variant and Variant Library Synthesis for DCAF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605973    OMIM disorders: --

    10 diseases for DCAF7:    About MalaCards
    campomelic dysplasia    epidermodysplasia verruciformis    cockayne syndrome    intrahepatic cholangiocarcinoma
    cholangiocarcinoma    hypoxia    melanoma    malaria
    breast cancer    neuronitis


    DCAF7 for disorders           About GeneDecksing


    Export disorders for DCAF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DCAF7 gene, integrated from 10 sources (see all 69):
    (articles sorted by number of sources associating them with DCAF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The an11 locus controlling flower pigmentation in petunia encodes a novel WD-repeat protein conserved in yeast, plants, and animals. (PubMed id 9192870)1, 2, 3 de Vetten N.... Koes R. (Genes Dev. 1997)
    2. HAN11 binds mDia1 and controls GLI1 transcriptional activity. (PubMed id 16887337)1, 2, 9 Morita K.... Watt F.M. (J. Dermatol. Sci. 2006)
    3. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. (PubMed id 20940704)1, 3 Ritterhoff S....Schmitz M.L. (EMBO J. 2010)
    4. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (Mol. Cell 2006)
    5. Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases. (PubMed id 14593110)1, 2 Skurat A.V. and Dietrich A.D. (J. Biol. Chem. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. OTUB1 modulates c-IAP1 stability to regulate signalling pathways. (PubMed id 23524849)1 Goncharov T....Vucic D. (EMBO J. 2013)
    8. Identification of the hypoxia-inducible factor 2I+ nuclear interactome in melanoma cells reveals master proteins involved in melanoma development. (PubMed id 23275444)1 Steunou A.L....Nieto L. (amp 2013)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 10238 HGNC: 30915 AceView: HAN11.1 Ensembl:ENSG00000136485 euGenes: HUgn10238
    ECgene: DCAF7 H-InvDB: DCAF7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DCAF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DCAF7 gene:
    Search GeneIP for patents involving DCAF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DCAF7  
     OriGene qPCR primer pairs and template standards for DCAF7   OriGene Protein Over-expression Lysate for DCAF7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DCAF7  
     OriGene qSTAR qPCR primer pairs in human, mouse for DCAF7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DCAF7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DCAF7   OriGene Custom Protein Services for DCAF7  

     
     
     Block miRNA regulation of human, mouse, rat DCAF7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DCAF7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCAF7 Predesigned siRNA for gene silencing in human, mouse, rat DCAF7
     QuantiFast Probe-based Assays in human, mouse, rat DCAF7 QuantiTect SYBR Green Assays in human, mouse, rat DCAF7
     Custom PCR Arrays for DCAF7 Search Chromatin IP Primers for DCAF7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCAF7  GeneGlobe Interaction Network for DCAF7
     Search Regulatory tfbs for DCAF7
     GenScript Custom Purified and Recombinant Proteins Services for DCAF7 GenScript cDNA clones with any tag delivered in your preferred vector for DCAF7
     GenScript Custom Assay Services for DCAF7 GenScript Custom overexpressing Cell Line Services for DCAF7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DCAF7
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DCAF7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DCAF7 antibodies
     DCAF7 proteins
     DCAF7 lysates
     Antibodies for DCAF7
     See all of Abcam's Antibodies, Kits and Proteins for DCAF7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DCAF7
     Proteins for DCAF7
     Antibodies for DCAF7
     ELISAs for DCAF7
     CLIAs for DCAF7



     Browse ESI BIO Cell Lines and PureStem Progenitors for DCAF7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF7
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DCAF7
     SwitchGear Promoter luciferase reporter plasmids for DCAF7
     Search ThermoFisher Antibodies for DCAF7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCAF7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCAF7
     LSBio Antibodies in human, mouse, rat for DCAF7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DCAF7 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4