Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DCAF6 Gene

protein-coding   GIFtS: 51
GCID: GC01P167905

DDB1 And CUL4 Associated Factor 6

(Previous name: IQ motif and WD repeats 1)
(Previous symbol: IQWD1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
DDB1 And CUL4 Associated Factor 61 2     ARCAP2 3
IQWD11 2 3 5     IQ Motif And WD Repeat-Containing Protein 12 3
NRIP2 3 5     1200006M05Rik2
IQ Motif And WD Repeats 11 2     MSTP0552
Androgen Receptor Complex-Associated Protein2 3     PC3262
Nuclear Receptor Interaction Protein2 3     DDB1- And CUL4-Associated Factor 62

External Ids:    HGNC: 300021   Entrez Gene: 558272   Ensembl: ENSG000001431647   OMIM: 6104945   UniProtKB: Q58WW23   

Export aliases for DCAF6 gene to outside databases

Previous GC identifers: GC01P166173 GC01P139151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DCAF6 Gene:
DCAF6 (DDB1 and CUL4 associated factor 6) is a protein-coding gene. Diseases associated with DCAF6 include essential hypertension, and hypertension. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is ENSG00000258465.

UniProtKB/Swiss-Prot: DCAF6_HUMAN, Q58WW2
Function: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear
receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DCAF6
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCAF6 promoter sequence
   Search Chromatin IP Primers for DCAF6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCAF6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q24.2   Ensembl cytogenetic band:  1q24.2   HGNC cytogenetic band: 1q23.3

DCAF6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF6 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P167905:  view genomic region     (about GC identifiers)

Start:
167,905,021 bp from pter      End:
168,045,081 bp from pter
Size:
140,061 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DCAF6_HUMAN, Q58WW2 (See protein sequence)
Recommended Name: DDB1- and CUL4-associated factor 6  
Size: 860 amino acids; 96292 Da
Subunit: Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A
and CUL4B
1 PDB 3D structure from and Proteopedia for DCAF6:
3I7O (3D)    
Secondary accessions: A2A295 B4DNB8 Q7L8I0 Q8IXH3 Q8TB19
Alternative splicing: 4 isoforms:  Q58WW2-1   Q58WW2-2   Q58WW2-3   Q58WW2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCAF6: NX_Q58WW2

Explore proteomics data for DCAF6 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys575, Lys694
  • Modification sites at PhosphoSitePlus

  • See DCAF6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001017977.1  NP_001185885.1  NP_001185886.1  NP_060912.2  

    ENSEMBL proteins: 
     ENSP00000356817   ENSP00000432304   ENSP00000311949   ENSP00000356814   ENSP00000396238  

    DCAF6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for DCAF6
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DCAF6
    GenScript Custom Purified and Recombinant Proteins Services for DCAF6
    Novus Biologicals DCAF6 Protein
    Novus Biologicals DCAF6 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCAF6

    DCAF6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DCAF6
    Novus Biologicals DCAF6 Antibodies
    Abcam antibodies for DCAF6
    Cloud-Clone Corp. Antibodies for DCAF6
    ThermoFisher Antibodies for DCAF6
    LSBio Antibodies in human, mouse, rat for DCAF6

    DCAF6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DCAF6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DCAF6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DCAF6
    Cloud-Clone Corp. CLIAs for DCAF6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR000048 IQ_motif_EF-hand-BS
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q58WW2

    ProtoNet protein and cluster: Q58WW2

    UniProtKB/Swiss-Prot: DCAF6_HUMAN, Q58WW2
    Similarity: Contains 1 IQ domain
    Similarity: Contains 7 WD repeats


    DCAF6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCAF6_HUMAN, Q58WW2
    Function: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear
    receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0030374ligand-dependent nuclear receptor transcription coactivator activity IDA15784617
         
    DCAF6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCAF6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCAF6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DCAF6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCAF6

    miRNA
    Products:
        
    miRTarBase miRNAs that target DCAF6:
    hsa-mir-100-5p (MIRT048430), hsa-let-7e-5p (MIRT051512)

    Block miRNA regulation of human, mouse, rat DCAF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF6 (see all 13):
    hsa-miR-495 hsa-miR-640 hsa-miR-3607-3p hsa-miR-92a hsa-miR-589* hsa-miR-3065-5p hsa-miR-367 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidDCAF6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DCAF6
    Predesigned siRNA for gene silencing in human, mouse, rat DCAF6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DCAF6

    Clone
    Products:
         
    OriGene clones in human, mouse for DCAF6 (see all 18)
    OriGene ORF clones in mouse, rat for DCAF6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): DCAF6 (NM_018442)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCAF6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DCAF6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DCAF6
    Browse ESI BIO Cell Lines and PureStem Progenitors for DCAF6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DCAF6_HUMAN, Q58WW2: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15784617
    GO:0080008Cul4-RING ubiquitin ligase complex IDA16949367

    DCAF6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



    UniProtKB/Swiss-Prot: DCAF6_HUMAN, Q58WW2
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCAF6
    Interactions:

        Search GeneGlobe Interaction Network for DCAF6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCAF6 (Q58WW22, 3 ENSP000003568174) via UniProtKB, MINT, STRING, and/or I2D (see all 40)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q12, 3, ENSP000003633904MINT-6503550 I2D: score=1 STRING: ENSP00000363390
    SMURF2Q9HAU42, 3, ENSP000002624354MINT-6503860 MINT-6503980 I2D: score=1 STRING: ENSP00000262435
    ACVR1Q047713, ENSP000002636404I2D: score=2 STRING: ENSP00000263640
    SMAD2Q157963, ENSP000002621604I2D: score=2 STRING: ENSP00000262160
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IGI15784617

    DCAF6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCAF6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DCAF6 gene (4 alternative transcripts): 
    NM_001017977.2  NM_001198956.1  NM_001198957.1  NM_018442.3  

    Unigene Cluster for DCAF6:

    DDB1 and CUL4 associated factor 6
    Hs.435741  [show with all ESTs]
    Unigene Representative Sequence: NM_001198956
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000450548 ENST00000470919 ENST00000367843(uc001gev.3 uc001gew.3 uc001gey.3)
    ENST00000470721 ENST00000312263 ENST00000367840(uc001gex.3 uc010plk.2)
    ENST00000455334 ENST00000491067 ENST00000460432 ENST00000489398(uc001gez.3)
    ENST00000478668 ENST00000432587
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DCAF6 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF6 (see all 13):
    hsa-miR-495 hsa-miR-640 hsa-miR-3607-3p hsa-miR-92a hsa-miR-589* hsa-miR-3065-5p hsa-miR-367 hsa-miR-25
    SwitchGear 3'UTR luciferase reporter plasmidDCAF6 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DCAF6
    Predesigned siRNA for gene silencing in human, mouse, rat DCAF6
    Clone
    Products:
         
    OriGene clones in human, mouse for DCAF6 (see all 18)
    OriGene ORF clones in mouse, rat for DCAF6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): DCAF6 (NM_018442)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCAF6
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DCAF6
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DCAF6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCAF6
      QuantiTect SYBR Green Assays in human, mouse, rat DCAF6
      QuantiFast Probe-based Assays in human, mouse, rat DCAF6

    Additional mRNA sequence: 

    AF116725.1 AF124434.1 AF150734.1 AK000984.1 AK093970.1 AK226181.1 AK297847.1 AL136738.1 
    AY766164.1 BC025262.1 DQ768089.1 

    Selected DOTS entries (see all 27):

    DT.454289  DT.99944657  DT.75106765  DT.91940623  DT.100010113  DT.100816543  DT.121423881  DT.97846546 
    DT.40132096  DT.121423916  DT.100816545  DT.75125490  DT.100816541  DT.40270297  DT.100816547  DT.121070287 
    DT.121423809  DT.121423822  DT.121423912  DT.92326395  DT.95328832  DT.95328833  DT.95351749  DT.100858317 

    Selected AceView cDNA sequences (see all 339):

    CB133882 AA626631 AI635143 AW069858 BM504525 BE504075 BE747286 CB528433 
    BQ221011 AA479515 BQ009829 BF195785 AA553594 BM726957 AI004624 AA371349 
    CA388643 BF063974 CB049183 CB160497 CA310484 AI082201 AA347779 BM477718 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCAF6 (see all 21)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^
    SP1:                          -                       -     -     -                 -                                                                 -     -   
    SP2:                          -                       -     -     -                 -                                                                 -         
    SP3:                                                                                                                                                            
    SP4:                                                  -     -     -                 -                                                                           
    SP5:                                                                                                                                                  -     -   

    ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c
    SP1:  -     -     -                 -                                                     -           -                 -                           
    SP2:                                                                                                                                                
    SP3:                                                                                      -           -                 -                           
    SP4:                                                                                                                                                
    SP5:  -     -     -     -     -     -                                                                                                               


    ECgene alternative splicing isoforms for DCAF6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DCAF6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGTTGCTT
    DCAF6 Expression
    About this image

    DCAF6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCAF6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.435741

    UniProtKB/Swiss-Prot: DCAF6_HUMAN, Q58WW2
    Tissue specificity: Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart,
    prostate, and adrenal gland

        Custom PCR Arrays for DCAF6
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DCAF6
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCAF6
    QuantiTect SYBR Green Assays in human, mouse, rat DCAF6
    QuantiFast Probe-based Assays in human, mouse, rat DCAF6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DCAF6 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcaf61 , 5 DDB1 and CUL4 associated factor 61, 5 88.59(n)1
    89.37(a)1
      1 (72.67 cM)5
    741061  NM_028759.11  NP_083035.11 
     1653295115 
    chicken
    (Gallus gallus)
    Aves DCAF61 DDB1 and CUL4 associated factor 6 77.9(n)
    81.68(a)
      418438  XM_416649.4  XP_416649.4 
    lizard
    (Anolis carolinensis)
    Reptilia DCAF66
    DDB1 and CUL4 associated factor 6
    76(a)
    1 ↔ 1
    3(163953859-164003640)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.110072 Transcribed sequence with moderate similarity to protein more 79.45(n)    BX777999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dcaf61 ddb1 and cul4 associated factor 6 63.18(n)
    67.69(a)
      564498  NM_001145090.1  NP_001138562.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0009811 AgaP_AGAP000981 50.39(n)
    49.68(a)
      1270478  XM_309177.5  XP_309177.5 


    ENSEMBL Gene Tree for DCAF6 (if available)
    TreeFam Gene Tree for DCAF6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DCAF6 gene
    ENSG000002584652  DCAF82  DCAF8L22  WDTC12  DCAF8L12  
    1 SIMAP similar gene for DCAF6 using alignment to 2 protein entries:     DCAF6_HUMAN (see all proteins):
    IQWD1

    DCAF6 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DCAF6
    PGOHUM00000246705


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DCAF6 (see all 2776)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1447293271,2
    --167908379(+) AGTAGA/GCCTTT 4 -- int10--------
    rs1880265331,2
    --167908503(+) ACTTTA/CCCTCC 4 -- int10--------
    rs718682961,2
    C--167908603(+) ATATC-/CATCATGT 4 -- int10--------
    rs1155956681,2
    F--167908641(+) TGTGGC/TGATAA 4 -- int11Minor allele frequency- T:0.04WA 118
    rs1385349581,2
    --167908899(+) GGGAGA/GCTGAG 4 -- int10--------
    rs1114920341,2
    F--167908913(+) GGAGAG/ATAGCT 4 -- int11Minor allele frequency- A:0.50CSA 2
    rs1446222381,2
    C--167909000(+) GCGTC-/ATAAA 
     TAAATAA
    ATAAA
    4 -- cds10--------
    rs1471848111,2
    --167909028(+) AAAGTA/GTGGTA 4 -- int10--------
    rs589737381,2
    C,F--167909093(+) GAAATA/GGATTC 4 -- int12Minor allele frequency- G:0.11WA 120
    rs1406238961,2
    C--167909137(+) GATTGC/TCTATC 4 -- int10--------

    HapMap Linkage Disequilibrium report for DCAF6 (167905021 - 168045081 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for DCAF6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv996972CNV Deletion20482838
    esv1732326CNV Deletion17803354
    esv2672177CNV Deletion23128226
    esv2312150CNV Deletion18987734
    esv2719228CNV Deletion23290073
    esv2497978CNV Deletion19546169
    esv32660CNV Loss17666407
    esv8761CNV Loss19470904
    nsv872525CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCAF6
    DNA2.0 Custom Variant and Variant Library Synthesis for DCAF6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610494    OMIM disorders: --

    8 diseases for DCAF6:    About MalaCards
    essential hypertension    hypertension    t-cell leukemia    schizophrenia
    prostatitis    prostate cancer    leukemia    malaria

    1 disease from the University of Copenhagen DISEASES database for DCAF6:
    Prostate cancer

    DCAF6 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: DCAF6 (0 documents)

    Export disorders for DCAF6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DCAF6 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with DCAF6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors. (PubMed id 15784617)1, 2, 9 Tsai T.C.... Chen S.L. (J. Biol. Chem. 2005)
    2. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (Mol. Cell 2006)
    3. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PubMed id 16964240)1, 2 Angers S.... Zheng N. (Nature 2006)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization. (PubMed id 18673574)1, 9 Han C.P....Kok L.F. (amp 2008)
    6. Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability. (PubMed id 17984071)1, 9 Chen P.H....Chen S.L. (Nucleic Acids Res. 2008)
    7. Identification of androgen-responsive microRNAs and androgen-related genes in breast cancer. (PubMed id 24222117)1 Nakano K....Sasano H. (Anticancer Res. 2013)
    8. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 55827 HGNC: 30002 AceView: IQWD1 Ensembl:ENSG00000143164 euGenes: HUgn55827
    ECgene: DCAF6 H-InvDB: DCAF6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DCAF6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DCAF6 gene:
    Search GeneIP for patents involving DCAF6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DCAF6  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DCAF6  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DCAF6  
     OriGene qSTAR qPCR primer pairs in human, mouse for DCAF6   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DCAF6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DCAF6   OriGene Custom Protein Services for DCAF6  

     
     
     Block miRNA regulation of human, mouse, rat DCAF6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DCAF6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCAF6 Predesigned siRNA for gene silencing in human, mouse, rat DCAF6
     QuantiFast Probe-based Assays in human, mouse, rat DCAF6 QuantiTect SYBR Green Assays in human, mouse, rat DCAF6
     Custom PCR Arrays for DCAF6 Search Chromatin IP Primers for DCAF6
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCAF6  Search GeneGlobe Interaction Network for DCAF6
     Search Regulatory tfbs for DCAF6
     GenScript Custom Purified and Recombinant Proteins Services for DCAF6 GenScript cDNA clones with any tag delivered in your preferred vector for DCAF6
     GenScript Custom Assay Services for DCAF6 GenScript Custom overexpressing Cell Line Services for DCAF6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DCAF6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DCAF6 antibodies
     DCAF6 proteins
     DCAF6 lysates
     Antibodies for DCAF6
     See all of Abcam's Antibodies, Kits and Proteins for DCAF6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DCAF6
     Antibodies for DCAF6
     ELISAs for DCAF6
     CLIAs for DCAF6



     Browse ESI BIO Cell Lines and PureStem Progenitors for DCAF6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF6
     SwitchGear 3'UTR luciferase reporter plasmids for DCAF6
     SwitchGear Promoter luciferase reporter plasmids for DCAF6
     ThermoFisher Antibodies for DCAF6
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat DCAF6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCAF6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DCAF6
     LSBio Antibodies in human, mouse, rat for DCAF6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DCAF6 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4