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Aliases for DCAF6 Gene

Aliases for DCAF6 Gene

  • DDB1 And CUL4 Associated Factor 6 2 3
  • IQWD1 3 4 6
  • NRIP 3 4 6
  • Androgen Receptor Complex-Associated Protein 3 4
  • IQ Motif And WD Repeat-Containing Protein 1 3 4
  • Nuclear Receptor Interaction Protein 3 4
  • IQ Motif And WD Repeats 1 2 3
  • ARCAP 3 4
  • DDB1- And CUL4-Associated Factor 6 3
  • 1200006M05Rik 3
  • MSTP055 3
  • PC326 3

External Ids for DCAF6 Gene

Previous HGNC Symbols for DCAF6 Gene

  • IQWD1

Previous GeneCards Identifiers for DCAF6 Gene

  • GC01P166173
  • GC01P139151

Summaries for DCAF6 Gene

GeneCards Summary for DCAF6 Gene

DCAF6 (DDB1 And CUL4 Associated Factor 6) is a Protein Coding gene. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is DCAF8.

UniProtKB/Swiss-Prot for DCAF6 Gene

  • Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF6 Gene

Genomics for DCAF6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAF6 Gene

Start:
167,935,783 bp from pter
End:
168,075,843 bp from pter
Size:
140,061 bases
Orientation:
Plus strand

Genomic View for DCAF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF6 Gene

No data available for Regulatory Elements for DCAF6 Gene

Proteins for DCAF6 Gene

  • Protein details for DCAF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q58WW2-DCAF6_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 6
    Protein Accession:
    Q58WW2
    Secondary Accessions:
    • A2A295
    • B4DNB8
    • Q7L8I0
    • Q8IXH3
    • Q8TB19

    Protein attributes for DCAF6 Gene

    Size:
    860 amino acids
    Molecular mass:
    96292 Da
    Quaternary structure:
    • Interacts with the nuclear receptors NR3C1 and AR in the presence of ligand. Interacts with DDB1, CUL4A and CUL4B.

    Three dimensional structures from OCA and Proteopedia for DCAF6 Gene

    Alternative splice isoforms for DCAF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF6 Gene

Proteomics data for DCAF6 Gene at MOPED

Post-translational modifications for DCAF6 Gene

  • Ubiquitination at Lys575 and Lys694
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCAF6 Gene

Domains for DCAF6 Gene

Gene Families for DCAF6 Gene

HGNC:
  • DCAF :DDB1 and CUL4 associated factors
  • WDR :WD repeat domain containing

Protein Domains for DCAF6 Gene

Graphical View of Domain Structure for InterPro Entry

Q58WW2

UniProtKB/Swiss-Prot:

DCAF6_HUMAN :
  • Q58WW2
Domain:
  • Contains 1 IQ domain.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF6: view

Function for DCAF6 Gene

Molecular function for DCAF6 Gene

UniProtKB/Swiss-Prot Function: Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity IDA 15784617
genes like me logo Genes that share ontologies with DCAF6: view

Animal Model Products

CRISPR Products

miRNA for DCAF6 Gene

miRTarBase miRNAs that target DCAF6

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF6 Gene

Localization for DCAF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF6 Gene COMPARTMENTS Subcellular localization image for DCAF6 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DCAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005925 focal adhesion IDA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF6: view

Pathways for DCAF6 Gene

SuperPathways for DCAF6 Gene

No Data Available

UniProtKB/Swiss-Prot Q58WW2-DCAF6_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IGI 15784617
genes like me logo Genes that share ontologies with DCAF6: view

No data available for Pathways by source for DCAF6 Gene

Transcripts for DCAF6 Gene

Unigene Clusters for DCAF6 Gene

DDB1 and CUL4 associated factor 6:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DCAF6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF6 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^
SP1: - - - - - - -
SP2: - - - - - -
SP3:
SP4: - - - -
SP5: - -
SP6: - -
SP7: - -
SP8: -
SP9:
SP10: - - -
SP11: - -
SP12: -
SP13:
SP14: - - - - - - -
SP15: - - - - - -
SP16: - - - - -
SP17: -
SP18:
SP19:
SP20:
SP21:

ExUns: 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b · 22c ^ 23a · 23b ^ 24a · 24b · 24c · 24d ^ 25 ^ 26a · 26b ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c
SP1: - - - - - - -
SP2:
SP3: - - -
SP4:
SP5: - - - - - -
SP6: -
SP7: - -
SP8: - -
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20: -
SP21:

Relevant External Links for DCAF6 Gene

GeneLoc Exon Structure for
DCAF6
ECgene alternative splicing isoforms for
DCAF6

Expression for DCAF6 Gene

mRNA expression in normal human tissues for DCAF6 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF6 Gene

This gene is overexpressed in Muscle - Skeletal (11.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF6 Gene

SOURCE GeneReport for Unigene cluster for DCAF6 Gene Hs.435741

mRNA Expression by UniProt/SwissProt for DCAF6 Gene

Q58WW2-DCAF6_HUMAN
Tissue specificity: Highly expressed in skeletal muscle and testis. Expressed to a lesser degree in heart, prostate, and adrenal gland.
genes like me logo Genes that share expressions with DCAF6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DCAF6 Gene

Orthologs for DCAF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF6 35
  • 99.65 (n)
  • 99.68 (a)
DCAF6 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCAF6 35
  • 91.33 (n)
  • 91.11 (a)
IQWD1 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF6 35
  • 91.92 (n)
  • 92.52 (a)
DCAF6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf6 35
  • 88.59 (n)
  • 89.37 (a)
Dcaf6 16
Dcaf6 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAF6 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF6 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf6 35
  • 88.48 (n)
  • 90.09 (a)
chicken
(Gallus gallus)
Aves DCAF6 35
  • 77.9 (n)
  • 81.68 (a)
DCAF6 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF6 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf6 35
  • 71.95 (n)
  • 78.72 (a)
Str.11007 35
zebrafish
(Danio rerio)
Actinopterygii dcaf6 35
  • 63.18 (n)
  • 67.69 (a)
dcaf6 36
  • 61 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000981 35
  • 50.39 (n)
  • 49.68 (a)
Species with no ortholog for DCAF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF6 Gene

ENSEMBL:
Gene Tree for DCAF6 (if available)
TreeFam:
Gene Tree for DCAF6 (if available)

Paralogs for DCAF6 Gene

Paralogs for DCAF6 Gene

Selected SIMAP similar genes for DCAF6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for DCAF6 Gene

genes like me logo Genes that share paralogs with DCAF6: view

Variants for DCAF6 Gene

Sequence variations from dbSNP and Humsavar for DCAF6 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs10044 -- 168,075,501(-) GTAAA(A/G)AAAAA utr-variant-3-prime
rs10693 -- 168,056,108(-) GAAAG(C/T)GTGAA intron-variant
rs149912 -- 167,988,565(-) GCTCT(A/T)AATAA intron-variant
rs169309 -- 168,064,031(-) AGGGG(A/G)AAAAA intron-variant
rs169310 -- 168,034,741(-) CTTCA(A/C)GTAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF6 Gene

Variant ID Type Subtype PubMed ID
esv32660 CNV Loss 17666407
nsv872525 CNV Gain 21882294
esv2497978 CNV Deletion 19546169
esv2312150 CNV Deletion 18987734
esv8761 CNV Loss 19470904
esv2672177 CNV Deletion 23128226
esv996972 CNV Deletion 20482838
esv1732326 CNV Deletion 17803354
esv2719228 CNV Deletion 23290073

Relevant External Links for DCAF6 Gene

HapMap Linkage Disequilibrium report
DCAF6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF6 Gene

Disorders for DCAF6 Gene

(1) University of Copenhagen DISEASES for DCAF6 Gene

Relevant External Links for DCAF6

Human Genome Epidemiology (HuGE) Navigator
DCAF6
genes like me logo Genes that share disorders with DCAF6: view

No data available for UniProtKB/Swiss-Prot for DCAF6 Gene

Publications for DCAF6 Gene

  1. NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors. (PMID: 15784617) Tsai T.C. … Chen S.L. (J. Biol. Chem. 2005) 3 4 23
  2. Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability. (PMID: 17984071) Chen P.H. … Chen S.L. (Nucleic Acids Res. 2008) 3 23
  3. Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization. (PMID: 18673574) Han C.P. … Kok L.F. (J. Exp. Clin. Cancer Res. 2008) 3 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4

Products for DCAF6 Gene

Sources for DCAF6 Gene

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