Aliases for DCAF6 Gene
External Ids for DCAF6 Gene
Previous HGNC Symbols for DCAF6 Gene
Previous GeneCards Identifiers for DCAF6 Gene
The protein encoded by this gene is a ligand-dependent coactivator of nuclear receptors, including nuclear receptor subfamily 3 group C member 1 (NR3C1), glucocorticoid receptor (GR), and androgen receptor (AR). The encoded protein and DNA damage binding protein 2 (DDB2) may act as tumor promoters and tumor suppressors, respectively, by regulating the level of androgen receptor in prostate tissues. In addition, this protein can act with glucocorticoid receptor to promote human papillomavirus gene expression. [provided by RefSeq, Mar 2017]
GeneCards Summary for DCAF6 Gene
DCAF6 (DDB1 And CUL4 Associated Factor 6) is a Protein Coding gene. Diseases associated with DCAF6 include Male Reproductive Organ Cancer. GO annotations related to this gene include ligand-dependent nuclear receptor transcription coactivator activity. An important paralog of this gene is DCAF8.
UniProtKB/Swiss-Prot for DCAF6 Gene
Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.