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Aliases for DCAF5 Gene

Aliases for DCAF5 Gene

  • DDB1 And CUL4 Associated Factor 5 2 3
  • WD Repeat-Containing Protein 22 3 4
  • WDR22 3 4
  • BCRG2 3 4
  • BCRP2 3 4
  • Breakpoint Cluster Region Protein, Uterine Leiomyoma, 2 3
  • Breakpoint Cluster Region Protein 2 4
  • WD Repeat Domain 22 2
  • D14S1461E 3
  • KIAA1824 4

External Ids for DCAF5 Gene

Previous HGNC Symbols for DCAF5 Gene

  • WDR22

Previous GeneCards Identifiers for DCAF5 Gene

  • GC14M068588
  • GC14M069517
  • GC14M049688

Summaries for DCAF5 Gene

GeneCards Summary for DCAF5 Gene

DCAF5 (DDB1 And CUL4 Associated Factor 5) is a Protein Coding gene. Diseases associated with DCAF5 include leiomyoma.

UniProtKB/Swiss-Prot for DCAF5 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF5 Gene

Genomics for DCAF5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAF5 Gene

Chromosome:
14
Start:
69,050,881 bp from pter
End:
69,153,393 bp from pter
Size:
102,513 bases
Orientation:
Minus strand

Genomic View for DCAF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF5 Gene

No data available for Regulatory Elements for DCAF5 Gene

Proteins for DCAF5 Gene

  • Protein details for DCAF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JK2-DCAF5_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 5
    Protein Accession:
    Q96JK2
    Secondary Accessions:
    • B2RN31
    • G3V4J7
    • O60559
    • Q8N3V3
    • Q8N3V5

    Protein attributes for DCAF5 Gene

    Size:
    942 amino acids
    Molecular mass:
    103963 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.
    SequenceCaution:
    • Sequence=AAC08965.1; Type=Frameshift; Positions=772, 809, 812, 817, 836, 844, 858; Evidence={ECO:0000305}; Sequence=BAB47453.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCAF5 Gene

    Alternative splice isoforms for DCAF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF5 Gene

Proteomics data for DCAF5 Gene at MOPED

Post-translational modifications for DCAF5 Gene

  • Ubiquitination at Lys 209 and Lys 678
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCAF5 Gene

Domains & Families for DCAF5 Gene

Protein Domains for DCAF5 Gene

Suggested Antigen Peptide Sequences for DCAF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q96JK2

UniProtKB/Swiss-Prot:

DCAF5_HUMAN :
  • Contains 6 WD repeats.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with DCAF5: view

Function for DCAF5 Gene

Molecular function for DCAF5 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF5: view
genes like me logo Genes that share phenotypes with DCAF5: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF5 Gene

Localization for DCAF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF5 Gene COMPARTMENTS Subcellular localization image for DCAF5 gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF5 Gene

Pathways & Interactions for DCAF5 Gene

SuperPathways for DCAF5 Gene

No Data Available

UniProtKB/Swiss-Prot Q96JK2-DCAF5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF5: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF5 Gene

Drugs & Compounds for DCAF5 Gene

No Compound Related Data Available

Transcripts for DCAF5 Gene

Unigene Clusters for DCAF5 Gene

DDB1 and CUL4 associated factor 5:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for DCAF5 Gene

GeneLoc Exon Structure for
DCAF5
ECgene alternative splicing isoforms for
DCAF5

Expression for DCAF5 Gene

mRNA expression in normal human tissues for DCAF5 Gene

Protein differential expression in normal tissues from HIPED for DCAF5 Gene

This gene is overexpressed in Adrenal (26.6) and Lung (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF5 Gene



SOURCE GeneReport for Unigene cluster for DCAF5 Gene Hs.509780

mRNA Expression by UniProt/SwissProt for DCAF5 Gene

Q96JK2-DCAF5_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DCAF5: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for DCAF5 Gene

Orthologs for DCAF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCAF5 35
  • 90.14 (n)
  • 93.13 (a)
DCAF5 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF5 35
  • 91.96 (n)
  • 94.58 (a)
DCAF5 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf5 35
  • 89.04 (n)
  • 91.38 (a)
Dcaf5 16
Dcaf5 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCAF5 35
  • 99.65 (n)
  • 99.79 (a)
DCAF5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf5 35
  • 89.79 (n)
  • 92.23 (a)
oppossum
(Monodelphis domestica)
Mammalia DCAF5 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF5 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF5 35
  • 72.45 (n)
  • 76.03 (a)
DCAF5 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
OneToMany
-- 36
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf5 35
  • 65.52 (n)
  • 65.97 (a)
zebrafish
(Danio rerio)
Actinopterygii dcaf5 35
  • 64.56 (n)
  • 71.72 (a)
dcaf5 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42233 36
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R11D1.1 36
  • 25 (a)
OneToOne
Species with no ortholog for DCAF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAF5 Gene

ENSEMBL:
Gene Tree for DCAF5 (if available)
TreeFam:
Gene Tree for DCAF5 (if available)

Paralogs for DCAF5 Gene

(2) SIMAP similar genes for DCAF5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCAF5: view

No data available for Paralogs for DCAF5 Gene

Variants for DCAF5 Gene

Sequence variations from dbSNP and Humsavar for DCAF5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs925817 -- 69,097,585(-) aaaaa(A/T)aaTAA intron-variant
rs963175 -- 69,120,367(-) atccc(A/T)acact intron-variant
rs1018315 -- 69,127,829(+) AAAAC(A/T)AAACA intron-variant
rs1105625 -- 69,082,287(-) AGGCA(A/G)TGAAA intron-variant
rs1127817 -- 69,055,137(-) CTCTG(C/T)GGCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DCAF5 Gene

Variant ID Type Subtype PubMed ID
nsv832823 CNV Loss 17160897
nsv1331 CNV Insertion 18451855
esv2663736 CNV Deletion 23128226

Variation tolerance for DCAF5 Gene

Residual Variation Intolerance Score: 4.48% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF5 Gene

HapMap Linkage Disequilibrium report
DCAF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF5 Gene

Disorders for DCAF5 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DCAF5 Gene - From: GeneCards

Disorder Aliases PubMed IDs
leiomyoma
  • leiomyomatous neoplasm
- elite association
Search DCAF5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DCAF5

Genetic Association Database (GAD)
DCAF5
Human Genome Epidemiology (HuGE) Navigator
DCAF5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF5
genes like me logo Genes that share disorders with DCAF5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCAF5 Gene

Publications for DCAF5 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 67
  2. A high-resolution metric HAPPY map of human chromosome 14. (PMID: 9521877) Dear P.H. … Piper M.B. (Genomics 1998) 2 67
  3. Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. (PMID: 9740667) Lynch R.A. … Menon A.G. (Genomics 1998) 2 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 67

Products for DCAF5 Gene

Sources for DCAF5 Gene

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