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Aliases for DCAF5 Gene

Aliases for DCAF5 Gene

  • DDB1 And CUL4 Associated Factor 5 2 3
  • WDR22 3 4 6
  • BCRP2 3 4 6
  • WD Repeat-Containing Protein 22 3 4
  • D14S1461E 3 6
  • BCRG2 3 4
  • Breakpoint Cluster Region Protein, Uterine Leiomyoma, 2 3
  • Breakpoint Cluster Region Protein 2 4
  • DDB1- And CUL4-Associated Factor 5 3
  • WD Repeat Domain 22 2
  • KIAA1824 4

External Ids for DCAF5 Gene

Previous Symbols for DCAF5 Gene

  • WDR22

Summaries for DCAF5 Gene

GeneCards Summary for DCAF5 Gene

DCAF5 (DDB1 And CUL4 Associated Factor 5) is a Protein Coding gene. Diseases associated with DCAF5 include leiomyoma.

UniProtKB/Swiss-Prot for DCAF5 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF5 Gene

Genomics for DCAF5 Gene

Genomic Location for DCAF5 Gene

Start:
69,050,881 bp from pter
End:
69,153,197 bp from pter
Size:
102,317 bases
Orientation:
Minus strand

Genomic View for DCAF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF5 Gene

No data available for Regulatory Elements for DCAF5 Gene

Proteins for DCAF5 Gene

  • Protein details for DCAF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JK2-DCAF5_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 5
    Protein Accession:
    Q96JK2
    Secondary Accessions:
    • B2RN31
    • G3V4J7
    • O60559
    • Q8N3V3
    • Q8N3V5

    Protein attributes for DCAF5 Gene

    Size:
    942 amino acids
    Molecular mass:
    103963 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.
    SequenceCaution:
    • Sequence=AAC08965.1; Type=Frameshift; Positions=772, 809, 812, 817, 836, 844, 858; Evidence={ECO:0000305}; Sequence=BAB47453.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCAF5 Gene

    Alternative splice isoforms for DCAF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF5 Gene

Proteomics data for DCAF5 Gene at MOPED

Post-translational modifications for DCAF5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys209 and Lys678

No data available for DME Specific Peptides for DCAF5 Gene

Domains for DCAF5 Gene

Gene Families for DCAF5 Gene

HGNC:
  • WDR :WD repeat domain containing
  • DCAF :DDB1 and CUL4 associated factors

Protein Domains for DCAF5 Gene

UniProtKB/Swiss-Prot:

DCAF5_HUMAN
Similarity:
  • Contains 6 WD repeats.:
    • Q96JK2
genes like me logo Genes that share domains with DCAF5: view

Function for DCAF5 Gene

Molecular function for DCAF5 Gene

UniProtKB/Swiss-Prot Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF5: view

Phenotypes for DCAF5 Gene

GenomeRNAi human phenotypes for DCAF5:
genes like me logo Genes that share phenotypes with DCAF5: view

miRNA for DCAF5 Gene

miRTarBase miRNAs that target DCAF5

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF5 Gene

Localization for DCAF5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF5 Gene COMPARTMENTS Subcellular localization image for DCAF5 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytosol 1

Gene Ontology (GO) - Cellular Components for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF5: view

Pathways for DCAF5 Gene

SuperPathways for DCAF5 Gene

No Data Available

UniProtKB/Swiss-Prot Q96JK2-DCAF5_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF5: view

No data available for Pathways by source for DCAF5 Gene

Transcripts for DCAF5 Gene

Unigene Clusters for DCAF5 Gene

DDB1 and CUL4 associated factor 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7 ^ 8
SP1: - - -
SP2: - - -
SP3:
SP4: - -
SP5: -

Relevant External Links for DCAF5 Gene

GeneLoc Exon Structure for
DCAF5
ECgene alternative splicing isoforms for
DCAF5

Expression for DCAF5 Gene

mRNA expression in normal human tissues for DCAF5 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF5 Gene

SOURCE GeneReport for Unigene cluster for DCAF5 Gene Hs.509780

mRNA Expression by UniProt/SwissProt for DCAF5 Gene

Q96JK2-DCAF5_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expressions with DCAF5: view

Orthologs for DCAF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF5 36
  • 99.65 (n)
  • 99.79 (a)
DCAF5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCAF5 36
  • 90.14 (n)
  • 93.13 (a)
DCAF5 37
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF5 36
  • 91.96 (n)
  • 94.58 (a)
DCAF5 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf5 36
  • 89.04 (n)
  • 91.38 (a)
Dcaf5 16
Dcaf5 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAF5 37
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF5 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf5 36
  • 89.79 (n)
  • 92.23 (a)
chicken
(Gallus gallus)
Aves DCAF5 36
  • 72.45 (n)
  • 76.03 (a)
DCAF5 37
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 71 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf5 36
  • 65.52 (n)
  • 65.97 (a)
zebrafish
(Danio rerio)
Actinopterygii dcaf5 36
  • 64.56 (n)
  • 71.72 (a)
dcaf5 37
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG42233 37
  • 31 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R11D1.1 37
  • 25 (a)
OneToOne
Species with no ortholog for DCAF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAF5 Gene

ENSEMBL:
Gene Tree for DCAF5 (if available)
TreeFam:
Gene Tree for DCAF5 (if available)

Paralogs for DCAF5 Gene

Selected SIMAP similar genes for DCAF5 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCAF5: view

No data available for Paralogs for DCAF5 Gene

Variants for DCAF5 Gene

Sequence variations from dbSNP and Humsavar for DCAF5 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs925817 -- 69,097,585(-) aaaaa(A/T)aaTAA intron-variant
rs963175 -- 69,120,367(-) atccc(A/T)acact intron-variant
rs1018315 -- 69,127,829(+) AAAAC(A/T)AAACA intron-variant
rs1105625 -- 69,082,287(-) AGGCA(A/G)TGAAA intron-variant
rs1127817 -- 69,055,137(-) CTCTG(C/T)GGCGC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for DCAF5 Gene

Variant ID Type Subtype PubMed ID
nsv832823 CNV Loss 17160897
nsv1331 CNV Insertion 18451855
esv2663736 CNV Deletion 23128226

Relevant External Links for DCAF5 Gene

HapMap Linkage Disequilibrium report
DCAF5

Disorders for DCAF5 Gene

(1) MalaCards Diseases for DCAF5 Gene

Search for DCAF5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DCAF5 Gene

Relevant External Links for DCAF5

Genetic Association Database (GAD)
DCAF5
Human Genome Epidemiology (HuGE) Navigator
DCAF5
genes like me logo Genes that share disorders with DCAF5: view

No data available for UniProtKB/Swiss-Prot for DCAF5 Gene

Publications for DCAF5 Gene

  1. Genomic and functional map of the chromosome 14 t(12;14) breakpoint cluster region in uterine leiomyoma. (PMID: 9740667) Lynch R.A. … Menon A.G. (Genomics 1998) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11347906) Nagase T. … Ohara O. (DNA Res. 2001) 3 4
  3. A high-resolution metric HAPPY map of human chromosome 14. (PMID: 9521877) Dear P.H. … Piper M.B. (Genomics 1998) 2 3
  4. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4
  5. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4

Products for DCAF5 Gene

Sources for DCAF5 Gene

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