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Aliases for DCAF4L2 Gene

Aliases for DCAF4L2 Gene

  • DDB1 And CUL4 Associated Factor 4-Like 2 2 3
  • WD Repeat-Containing Protein 21C 3 4
  • WD Repeat Domain 21C 2 3
  • WDR21C 3 4
  • DDB1- And CUL4-Associated Factor 4-Like Protein 2 3

External Ids for DCAF4L2 Gene

Previous HGNC Symbols for DCAF4L2 Gene

  • WDR21C

Previous GeneCards Identifiers for DCAF4L2 Gene

  • GC08M088954
  • GC08M084093
  • GC08M088882

Summaries for DCAF4L2 Gene

GeneCards Summary for DCAF4L2 Gene

DCAF4L2 (DDB1 And CUL4 Associated Factor 4-Like 2) is a Protein Coding gene. An important paralog of this gene is DCAF4L1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4L2 Gene

Genomics for DCAF4L2 Gene

Genomic Location for DCAF4L2 Gene

Start:
87,870,743 bp from pter
End:
87,874,068 bp from pter
Size:
3,326 bases
Orientation:
Minus strand

Genomic View for DCAF4L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF4L2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4L2 Gene

No data available for Regulatory Elements for DCAF4L2 Gene

Proteins for DCAF4L2 Gene

  • Protein details for DCAF4L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NA75-DC4L2_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 4-like protein 2
    Protein Accession:
    Q8NA75
    Secondary Accessions:

    Protein attributes for DCAF4L2 Gene

    Size:
    395 amino acids
    Molecular mass:
    43747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF4L2 Gene

Proteomics data for DCAF4L2 Gene at MOPED

Post-translational modifications for DCAF4L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF4L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF4L2 Gene

Domains for DCAF4L2 Gene

Gene Families for DCAF4L2 Gene

HGNC:
  • WDR :WD repeat domain containing

Protein Domains for DCAF4L2 Gene

Suggested Antigen Peptide Sequences for DCAF4L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NA75

UniProtKB/Swiss-Prot:

DC4L2_HUMAN :
  • Q8NA75
Similarity:
  • Contains 2 WD repeats.
genes like me logo Genes that share domains with DCAF4L2: view

Function for DCAF4L2 Gene

Gene Ontology (GO) - Molecular Function for DCAF4L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF4L2: view

miRNA for DCAF4L2 Gene

miRTarBase miRNAs that target DCAF4L2

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF4L2 Gene

Localization for DCAF4L2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF4L2 Gene COMPARTMENTS Subcellular localization image for DCAF4L2 gene
Compartment Confidence
peroxisome 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCAF4L2 Gene

Pathways for DCAF4L2 Gene

SuperPathways for DCAF4L2 Gene

No Data Available

Interacting Proteins for DCAF4L2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000316496%0d%0a9606.ENSP00000319664%0d%0a9606.ENSP00000301764%0d%0a
Selected Interacting proteins: ENSP00000316496 for DCAF4L2 Gene via STRING

Gene Ontology (GO) - Biological Process for DCAF4L2 Gene

None

No data available for Pathways by source for DCAF4L2 Gene

Transcripts for DCAF4L2 Gene

mRNA/cDNA for DCAF4L2 Gene

(11) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF4L2 Gene

DDB1 and CUL4 associated factor 4-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4L2 Gene

No ASD Table

Relevant External Links for DCAF4L2 Gene

GeneLoc Exon Structure for
DCAF4L2
ECgene alternative splicing isoforms for
DCAF4L2

Expression for DCAF4L2 Gene

mRNA expression in normal human tissues for DCAF4L2 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF4L2 Gene

This gene is overexpressed in Testis (50.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DCAF4L2 Gene

SOURCE GeneReport for Unigene cluster for DCAF4L2 Gene Hs.371738

genes like me logo Genes that share expressions with DCAF4L2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DCAF4L2 Gene

Orthologs for DCAF4L2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4L2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF4L2 35
  • 98.99 (n)
  • 97.72 (a)
cow
(Bos Taurus)
Mammalia WDR21A 36
  • 57 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 60 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dcaf4 36
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 49 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii wdr21 36
  • 51 (a)
OneToMany
Species with no ortholog for DCAF4L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4L2 Gene

ENSEMBL:
Gene Tree for DCAF4L2 (if available)
TreeFam:
Gene Tree for DCAF4L2 (if available)

Paralogs for DCAF4L2 Gene

Paralogs for DCAF4L2 Gene

Selected SIMAP similar genes for DCAF4L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCAF4L2: view

Variants for DCAF4L2 Gene

Sequence variations from dbSNP and Humsavar for DCAF4L2 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1182764 -- 87,874,961(-) ggagg(C/T)ggagc upstream-variant-2KB
rs10107694 -- 87,870,344(+) AGTAT(A/C)ATGCA downstream-variant-500B
rs11784027 -- 87,875,154(+) caggc(A/G)tgagc upstream-variant-2KB
rs13278530 -- 87,875,306(+) ctccc(C/G)ggttc upstream-variant-2KB
rs16874282 -- 87,870,873(+) CCGCA(C/G)CTAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DCAF4L2 Gene

Variant ID Type Subtype PubMed ID
nsv465734 CNV Gain 19166990
nsv831384 CNV Gain 17160897
nsv891168 CNV Loss 21882294
nsv891169 CNV Gain 21882294
nsv831385 CNV Loss 17160897

Relevant External Links for DCAF4L2 Gene

HapMap Linkage Disequilibrium report
DCAF4L2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF4L2 Gene

Disorders for DCAF4L2 Gene

No disorders were found for DCAF4L2 Gene.

No data available for UniProtKB/Swiss-Prot for DCAF4L2 Gene

Publications for DCAF4L2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study. (PMID: 23512105) Beaty T.H. … Ruczinski I. (Hum. Genet. 2013) 3
  4. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DCAF4L2 Gene

Sources for DCAF4L2 Gene

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