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Aliases for DCAF4L1 Gene

Aliases for DCAF4L1 Gene

  • DDB1 And CUL4 Associated Factor 4 Like 1 2 3 5
  • WD Repeat-Containing Protein 21B 3 4
  • WD Repeat Domain 21B 2 3
  • WDR21B 3 4
  • DDB1- And CUL4-Associated Factor 4-Like Protein 1 3

External Ids for DCAF4L1 Gene

Previous HGNC Symbols for DCAF4L1 Gene

  • WDR21B

Previous GeneCards Identifiers for DCAF4L1 Gene

  • GC04P041679
  • GC04P041305

Summaries for DCAF4L1 Gene

GeneCards Summary for DCAF4L1 Gene

DCAF4L1 (DDB1 And CUL4 Associated Factor 4 Like 1) is a Protein Coding gene. An important paralog of this gene is DCAF4.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4L1 Gene

Genomics for DCAF4L1 Gene

Regulatory Elements for DCAF4L1 Gene

Enhancers for DCAF4L1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G041938 0.8 ENCODE 11 -42.5 -42451 1.4 MAX CEBPG RAD21 IRF9 ZNF316 SCRT2 TRIM24 MAFK GATAD2A HLF DCAF4L1 TMEM33 GC04P041959
GH04G041418 0.8 Ensembl ENCODE dbSUPER 4.8 -563.1 -563134 1.1 LIMCH1 APBB2 DCAF4L1 GC04P041427 GC04P041402
GH04G041419 0.4 dbSUPER 4.4 -561.3 -561333 2.1 ZNF366 LIMCH1 SHISA3 DCAF4L1 GC04P041427 GC04P041402
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCAF4L1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCAF4L1 Gene

41,981,696 bp from pter
41,986,467 bp from pter
4,772 bases
Plus strand

Genomic View for DCAF4L1 Gene

Genes around DCAF4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4L1 Gene

Proteins for DCAF4L1 Gene

  • Protein details for DCAF4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 4-like protein 1
    Protein Accession:
    Secondary Accessions:
    • B3KVI3
    • Q3ZCW8
    • Q499Y5
    • Q9UFI0

    Protein attributes for DCAF4L1 Gene

    396 amino acids
    Molecular mass:
    44264 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH35027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DCAF4L1 Gene

Post-translational modifications for DCAF4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF4L1 Gene

Domains & Families for DCAF4L1 Gene

Gene Families for DCAF4L1 Gene

Protein Domains for DCAF4L1 Gene

Suggested Antigen Peptide Sequences for DCAF4L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF4L1: view

No data available for UniProtKB/Swiss-Prot for DCAF4L1 Gene

Function for DCAF4L1 Gene

genes like me logo Genes that share phenotypes with DCAF4L1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4L1 Gene

Localization for DCAF4L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF4L1 gene
Compartment Confidence
nucleus 2
cytosol 2
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DCAF4L1 Gene

Pathways & Interactions for DCAF4L1 Gene

SuperPathways for DCAF4L1 Gene

No Data Available

Interacting Proteins for DCAF4L1 Gene

Gene Ontology (GO) - Biological Process for DCAF4L1 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCAF4L1 Gene

Drugs & Compounds for DCAF4L1 Gene

No Compound Related Data Available

Transcripts for DCAF4L1 Gene

mRNA/cDNA for DCAF4L1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF4L1 Gene

DDB1 and CUL4 associated factor 4-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4L1 Gene

No ASD Table

Relevant External Links for DCAF4L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF4L1 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF4L1 Gene

This gene is overexpressed in Testis (x28.2).

Protein differential expression in normal tissues from HIPED for DCAF4L1 Gene

This gene is overexpressed in Testis (40.5) and Ovary (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCAF4L1 Gene

Protein tissue co-expression partners for DCAF4L1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAF4L1 Gene:


SOURCE GeneReport for Unigene cluster for DCAF4L1 Gene:

genes like me logo Genes that share expression patterns with DCAF4L1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF4L1 Gene

Orthologs for DCAF4L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF4L1 34 35
  • 99.41 (n)
(Canis familiaris)
Mammalia -- 35
  • 62 (a)
(Bos Taurus)
Mammalia WDR21A 35
  • 61 (a)
(Mus musculus)
Mammalia Dcaf4 35
  • 55 (a)
(Monodelphis domestica)
Mammalia -- 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 34 (a)
-- 35
  • 34 (a)
(Gallus gallus)
Aves -- 35
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 46 (a)
(Danio rerio)
Actinopterygii wdr21 35
  • 52 (a)
Species where no ortholog for DCAF4L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4L1 Gene

Gene Tree for DCAF4L1 (if available)
Gene Tree for DCAF4L1 (if available)

Paralogs for DCAF4L1 Gene

Paralogs for DCAF4L1 Gene

(2) SIMAP similar genes for DCAF4L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAF4L1: view

Variants for DCAF4L1 Gene

Sequence variations from dbSNP and Humsavar for DCAF4L1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000410786 -- 41,981,634(+) ACACA(C/T)CTGTA upstream-variant-2KB
rs1001674645 -- 41,981,027(+) GAGAC(C/T)ATCTG upstream-variant-2KB
rs1001957709 -- 41,981,351(+) TCGGC(A/C)AAGCA upstream-variant-2KB
rs1002522322 -- 41,986,077(+) CACTA(C/G)TGTTT utr-variant-3-prime
rs1002677299 -- 41,979,759(+) GTGGG(A/G)TCAGG upstream-variant-2KB

Variation tolerance for DCAF4L1 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCAF4L1 Gene

Disorders for DCAF4L1 Gene

Relevant External Links for DCAF4L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCAF4L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF4L1 Gene

Publications for DCAF4L1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  4. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for DCAF4L1 Gene

Sources for DCAF4L1 Gene

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