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Aliases for DCAF4L1 Gene

Aliases for DCAF4L1 Gene

  • DDB1 And CUL4 Associated Factor 4-Like 1 2 3
  • WD Repeat-Containing Protein 21B 3 4
  • WD Repeat Domain 21B 2 3
  • WDR21B 3 4

External Ids for DCAF4L1 Gene

Previous HGNC Symbols for DCAF4L1 Gene

  • WDR21B

Previous GeneCards Identifiers for DCAF4L1 Gene

  • GC04P041679
  • GC04P041305

Summaries for DCAF4L1 Gene

GeneCards Summary for DCAF4L1 Gene

DCAF4L1 (DDB1 And CUL4 Associated Factor 4-Like 1) is a Protein Coding gene. An important paralog of this gene is DCAF4.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4L1 Gene

Genomics for DCAF4L1 Gene

Genomic Location for DCAF4L1 Gene

Chromosome:
4
Start:
41,981,696 bp from pter
End:
41,986,467 bp from pter
Size:
4,772 bases
Orientation:
Plus strand

Genomic View for DCAF4L1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4L1 Gene

No data available for Regulatory Elements for DCAF4L1 Gene

Proteins for DCAF4L1 Gene

  • Protein details for DCAF4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SXM0-DC4L1_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 4-like protein 1
    Protein Accession:
    Q3SXM0
    Secondary Accessions:
    • B3KVI3
    • Q3ZCW8
    • Q499Y5
    • Q9UFI0

    Protein attributes for DCAF4L1 Gene

    Size:
    396 amino acids
    Molecular mass:
    44264 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH35027.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DCAF4L1 Gene

Proteomics data for DCAF4L1 Gene at MOPED

Post-translational modifications for DCAF4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF4L1 Gene

Domains & Families for DCAF4L1 Gene

Gene Families for DCAF4L1 Gene

Protein Domains for DCAF4L1 Gene

Suggested Antigen Peptide Sequences for DCAF4L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3SXM0

UniProtKB/Swiss-Prot:

DC4L1_HUMAN :
  • Contains 2 WD repeats.
Similarity:
  • Contains 2 WD repeats.
genes like me logo Genes that share domains with DCAF4L1: view

Function for DCAF4L1 Gene

Gene Ontology (GO) - Molecular Function for DCAF4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF4L1: view
genes like me logo Genes that share phenotypes with DCAF4L1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF4L1

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4L1 Gene

Localization for DCAF4L1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DCAF4L1 Gene

Pathways & Interactions for DCAF4L1 Gene

SuperPathways for DCAF4L1 Gene

No Data Available

Interacting Proteins for DCAF4L1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000327796%0d%0a9606.ENSP00000301764%0d%0a9606.ENSP00000304102%0d%0a9606.ENSP00000364589%0d%0a
Selected Interacting proteins: ENSP00000327796 for DCAF4L1 Gene via STRING

Gene Ontology (GO) - Biological Process for DCAF4L1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCAF4L1 Gene

Drugs & Compounds for DCAF4L1 Gene

No Compound Related Data Available

Transcripts for DCAF4L1 Gene

mRNA/cDNA for DCAF4L1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF4L1 Gene

DDB1 and CUL4 associated factor 4-like 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF4L1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4L1 Gene

No ASD Table

Relevant External Links for DCAF4L1 Gene

GeneLoc Exon Structure for
DCAF4L1
ECgene alternative splicing isoforms for
DCAF4L1

Expression for DCAF4L1 Gene

mRNA expression in normal human tissues for DCAF4L1 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF4L1 Gene

This gene is overexpressed in Testis (x28.2).

Protein differential expression in normal tissues from HIPED for DCAF4L1 Gene

This gene is overexpressed in Testis (40.5) and Ovary (25.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DCAF4L1 Gene



SOURCE GeneReport for Unigene cluster for DCAF4L1 Gene Hs.213307

genes like me logo Genes that share expression patterns with DCAF4L1: view

Protein tissue co-expression partners for DCAF4L1 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for DCAF4L1 Gene

Orthologs for DCAF4L1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4L1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF4L1 35
  • 99.41 (n)
  • 99.24 (a)
DCAF4L1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR21A 36
  • 61 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 51 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dcaf4 36
  • 55 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 34 (a)
ManyToMany
-- 36
  • 34 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 48 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 46 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii wdr21 36
  • 52 (a)
OneToMany
Species with no ortholog for DCAF4L1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4L1 Gene

ENSEMBL:
Gene Tree for DCAF4L1 (if available)
TreeFam:
Gene Tree for DCAF4L1 (if available)

Paralogs for DCAF4L1 Gene

Paralogs for DCAF4L1 Gene

(2) SIMAP similar genes for DCAF4L1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DCAF4L1: view

Variants for DCAF4L1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DCAF4L1 Gene

Variant ID Type Subtype PubMed ID
dgv5529n71 CNV Loss 21882294
nsv878960 CNV Loss 21882294
dgv5530n71 CNV Loss 21882294
dgv5531n71 CNV Loss 21882294
dgv5532n71 CNV Loss 21882294

Variation tolerance for DCAF4L1 Gene

Residual Variation Intolerance Score: 28.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF4L1 Gene

HapMap Linkage Disequilibrium report
DCAF4L1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DCAF4L1 Gene

Disorders for DCAF4L1 Gene

Relevant External Links for DCAF4L1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF4L1
genes like me logo Genes that share disorders with DCAF4L1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF4L1 Gene

Publications for DCAF4L1 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 67
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for DCAF4L1 Gene

Sources for DCAF4L1 Gene

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