DCAF4L1 Gene
protein-coding GIFtS: 37
GCID: GC04P041983
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DDB1 and CUL4 associated factor 4-like 1(Previous name: WD repeat domain 21B )
(Previous symbol: WDR21B)
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Aliases
for DCAF4L1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DDB1 And CUL4 Associated Factor 4-Like 11 2 | | WDR21B1 2 3 | | WD Repeat Domain 21B1 2 | | WD Repeat-Containing Protein 21B2 3 | | DDB1- And CUL4-Associated Factor 4-Like Protein 12 |
Export aliases for DCAF4L1 gene to outside databasesPrevious GC identifers: GC04P041679 GC04P041305 |
Summaries
for DCAF4L1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for DCAF4L1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006238.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DCAF4L1
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCAF4L1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF4L1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p13 Ensembl cytogenetic band: 4p13 HGNC cytogenetic band: 4p13DCAF4L1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P041983: view genomic region
(about GC identifiers)
Start:
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41,983,713 bp from pter |
End:
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41,988,484 bp from pter |
Size:
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4,772 bases |
Orientation:
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plus strand |
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Proteins
for DCAF4L1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DC4L1_HUMAN, Q3SXM0 (See
protein sequence)Recommended Name: DDB1- and CUL4-associated factor 4-like protein 1 Size: 396 amino acids; 44264 Da
Sequence caution: Sequence=AAH35027.1; Type=Erroneous initiation;
Secondary accessions: B3KVI3 Q3ZCW8 Q499Y5 Q9UFI0Explore the universe of human proteins at neXtProt for DCAF4L1: NX_Q3SXM0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3SXM0
DCAF4L1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001025126.2
ENSEMBL proteins: ENSP00000327796
Human Recombinant Protein Products:
DCAF4L1 Antibody Products:
Assay Products for DCAF4L1: |
Protein
Domains /
Families
for DCAF4L1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCAF4L1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3SXM0ProtoNet protein and cluster: Q3SXM0 UniProtKB/Swiss-Prot: DC4L1_HUMAN, Q3SXM0Similarity: Contains 2 WD repeats |
Function
for DCAF4L1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF4L1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF4L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for DCAF4L1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF4L1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF4L1 |
|
Pathways & Interactions
for DCAF4L1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCAF4L1
|
Drugs & Compounds
for DCAF4L1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCAF4L1
Search CenterWatch for drugs/clinical trials and news about DCAF4L1 / DC4L1
|
Transcripts
for DCAF4L1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCAF4L1 gene: NM_001029955.3 Unigene Cluster for DCAF4L1: DDB1 and CUL4 associated factor 4-like 1 Hs.213307 [show with all ESTs]Unigene Representative Sequence: NM_0010299551 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000333141(uc003gwk.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF4L1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF4L1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCAF4L1 (NM_001029955) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAF4L1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF4L1 |
Additional cDNA sequence: AK122914.1 BC035027.1 BC052943.1 BC104224.1 BC104225.1 2 DOTS entries: DT.40302320 DT.40230833 17 AceView cDNA sequences: AL045268 AA884411 AL045282 AI916962 AW292317 BU561160 BQ432632 AK122914 BC035027 BC052943 BQ441622 AI962648 BI463947 AI825047 BG718392 AL122070 CD358409
GeneLoc Exon Structure
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Expression
for DCAF4L1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCAF4L1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGTTTATAT
About this image
See DCAF4L1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCAF4L1
SOURCE GeneReport for Unigene cluster: Hs.213307
SABiosciences Custom PCR Arrays for DCAF4L1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAF4L1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DCAF4L1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAF4L1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAF4L1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF4L1 |
Orthologs
for DCAF4L1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for DCAF4L1 gene from 5/13 species (see all 13) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DCAF46 |
Uncharacterized protein |
48(a) |
1 → many |
5(28634148-28646448) |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
47(a) |
1 → many |
1(38838975-38849503) |
zebrafish
(Danio rerio) |
Actinopterygii |
wdr216 |
WD repeat domain 21 |
52(a) |
1 → many |
16(4127039-4130635) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT5G173706 |
transducin/WD40 domain-containing protein |
15(a) |
1 → many |
5(5721636-5724719) |
rice
(Oryza sativa) |
Liliopsida |
-- |
WD-40 repeat family protein, putative, expressed |
15(a) |
1 → many |
7(431084-436658) |
Species with no ortholog for DCAF4L1
ENSEMBL Gene Tree for DCAF4L1 (if available)
TreeFam Gene Tree for DCAF4L1 (if available) |
Paralogs
for DCAF4L1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DCAF4L1 gene
- DCAF4L22 DCAF42
2 SIMAP similar genes for DCAF4L1 using alignment to 2 protein entries: DC4L1_HUMAN (see all proteins):DCAF4 DCAF4L2
DCAF4L1 for paralogs About GeneDecksing
|
Genomic Variants
for DCAF4L1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAF4L1 |
|
Disorders
/ Diseases
for DCAF4L1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DCAF4L1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCAF4L1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DCAF4L1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for DCAF4L1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing DCAF4L1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCAF4L1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCAF4L1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCAF4L1 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for DCAF4L1 gene:
Search GeneIP for patents involving DCAF4L1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCAF4L1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | | | DCAF4L1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF4L1 |
|  |  |  | | | | Search ThermoFisher Antibodies for DCAF4L1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF4L1 |
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