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Aliases for DCAF4 Gene

Aliases for DCAF4 Gene

  • DDB1 And CUL4 Associated Factor 4 2 3
  • WD Repeat-Containing Protein 21A 3 4
  • WD Repeat Domain 21A 2 3
  • WDR21A 3 4
  • WDR21 3 4
  • WD Repeat Domain 21 2

External Ids for DCAF4 Gene

Previous HGNC Symbols for DCAF4 Gene

  • WDR21
  • WDR21A

Previous GeneCards Identifiers for DCAF4 Gene

  • GC14P072464
  • GC14P073393
  • GC14P053559

Summaries for DCAF4 Gene

Entrez Gene Summary for DCAF4 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF4 Gene

DCAF4 (DDB1 And CUL4 Associated Factor 4) is a Protein Coding gene. An important paralog of this gene is DCAF4L1.

UniProtKB/Swiss-Prot for DCAF4 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4 Gene

Genomics for DCAF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAF4 Gene

72,926,332 bp from pter
72,962,098 bp from pter
35,767 bases
Plus strand

Genomic View for DCAF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4 Gene

No data available for Regulatory Elements for DCAF4 Gene

Proteins for DCAF4 Gene

  • Protein details for DCAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 4
    Protein Accession:
    Secondary Accessions:
    • B4DUT6
    • G3V522
    • Q86U31
    • Q8IV10
    • Q96K22
    • Q9Y4P5

    Protein attributes for DCAF4 Gene

    495 amino acids
    Molecular mass:
    55694 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.

    Three dimensional structures from OCA and Proteopedia for DCAF4 Gene

    Alternative splice isoforms for DCAF4 Gene


neXtProt entry for DCAF4 Gene

Proteomics data for DCAF4 Gene at MOPED

Post-translational modifications for DCAF4 Gene

  • Ubiquitination at Lys 460
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCAF4 Gene

Domains & Families for DCAF4 Gene

Protein Domains for DCAF4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 WD repeats.
  • Contains 2 WD repeats.
genes like me logo Genes that share domains with DCAF4: view

Function for DCAF4 Gene

Molecular function for DCAF4 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF4: view

Phenotypes for DCAF4 Gene

GenomeRNAi human phenotypes for DCAF4:
genes like me logo Genes that share phenotypes with DCAF4: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4 Gene

Localization for DCAF4 Gene

Subcellular locations from

Jensen Localization Image for DCAF4 Gene COMPARTMENTS Subcellular localization image for DCAF4 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF4 Gene

Pathways & Interactions for DCAF4 Gene

SuperPathways for DCAF4 Gene

No Data Available

UniProtKB/Swiss-Prot Q8WV16-DCAF4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF4: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF4 Gene

Drugs & Compounds for DCAF4 Gene

(1) Drugs for DCAF4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
corticosteroids Pharma 0
genes like me logo Genes that share compounds with DCAF4: view

Transcripts for DCAF4 Gene

Unigene Clusters for DCAF4 Gene

DDB1 and CUL4 associated factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - -

Relevant External Links for DCAF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF4 Gene

mRNA expression in normal human tissues for DCAF4 Gene

SOURCE GeneReport for Unigene cluster for DCAF4 Gene Hs.331491

genes like me logo Genes that share expression patterns with DCAF4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DCAF4 Gene

Orthologs for DCAF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCAF4 35
  • 84.45 (n)
  • 81.54 (a)
WDR21A 36
  • 81 (a)
(Canis familiaris)
Mammalia DCAF4 35
  • 86.95 (n)
  • 87.42 (a)
-- 36
  • 87 (a)
(Mus musculus)
Mammalia Dcaf4 35
  • 83.44 (n)
  • 81.97 (a)
Dcaf4 16
Dcaf4 36
  • 77 (a)
(Pan troglodytes)
Mammalia DCAF4 35
  • 99.53 (n)
  • 99.39 (a)
DCAF4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dcaf4 35
  • 83.23 (n)
  • 82.39 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
-- 36
  • 41 (a)
(Gallus gallus)
Aves DCAF4 35
  • 69.11 (n)
  • 69.4 (a)
-- 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf4 35
  • 59.18 (n)
  • 52.48 (a)
(Danio rerio)
Actinopterygii wdr21 35
  • 61.45 (n)
  • 59.88 (a)
wdr21 36
  • 58 (a)
Species with no ortholog for DCAF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4 Gene

Gene Tree for DCAF4 (if available)
Gene Tree for DCAF4 (if available)

Paralogs for DCAF4 Gene

Paralogs for DCAF4 Gene

(2) SIMAP similar genes for DCAF4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCAF4: view

Variants for DCAF4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF4 Gene

An intronic G-to-A transition (rs2535913) has been associated with leukocyte telomere length. The minor A allele is associated with shorter telomeres and lower expression in lymphoblastoid cells and in sun-exposed skin (PubMed:25624462).

Sequence variations from dbSNP and Humsavar for DCAF4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2572 -- 72,959,582(-) CTCAC(A/G)AACTG utr-variant-3-prime, intron-variant, nc-transcript-variant
rs741227 -- 72,942,063(+) GGGGA(C/T)GTAGG intron-variant
rs887936 -- 72,939,960(-) GGAAC(A/G)GGTCT intron-variant
rs1076458 -- 72,927,170(+) CGGGG(A/G)CTTCA intron-variant
rs1079560 -- 72,926,849(-) GCAGG(G/T)CTCAG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for DCAF4 Gene

Variant ID Type Subtype PubMed ID
esv274200 CNV Insertion 20981092

Variation tolerance for DCAF4 Gene

Residual Variation Intolerance Score: 89.84% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for DCAF4 Gene

Relevant External Links for DCAF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DCAF4: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF4 Gene

Publications for DCAF4 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. DCAF4, a novel gene associated with leucocyte telomere length. (PMID: 25624462) Mangino M. … Aviv A. (J. Med. Genet. 2015) 67
  4. Association between WDR21A polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients. (PMID: 22366774) Cho S.H. … Park C.S. (Pharmacogenet. Genomics 2012) 67
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 67

Products for DCAF4 Gene

Sources for DCAF4 Gene

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