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Aliases for DCAF4 Gene

Aliases for DCAF4 Gene

  • DDB1 And CUL4 Associated Factor 4 2 3 5
  • WD Repeat-Containing Protein 21A 3 4
  • WD Repeat Domain 21A 2 3
  • WDR21A 3 4
  • WDR21 3 4
  • DDB1- And CUL4-Associated Factor 4 3
  • WD Repeat Domain 21 2

External Ids for DCAF4 Gene

Previous HGNC Symbols for DCAF4 Gene

  • WDR21
  • WDR21A

Previous GeneCards Identifiers for DCAF4 Gene

  • GC14P072464
  • GC14P073393
  • GC14P053559

Summaries for DCAF4 Gene

Entrez Gene Summary for DCAF4 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF4 Gene

DCAF4 (DDB1 And CUL4 Associated Factor 4) is a Protein Coding gene. An important paralog of this gene is DCAF4L1.

UniProtKB/Swiss-Prot for DCAF4 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4 Gene

Genomics for DCAF4 Gene

Regulatory Elements for DCAF4 Gene

Enhancers for DCAF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F072924 0.4 ENCODE 20.3 -0.1 -89 3.6 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 FOS DCAF4 LOC100420966 PSEN1 LOC101928123 RBM25 ELMSAN1 ZFYVE1 HEATR4 DPF3
GH14F072891 0.2 ENCODE 17.4 -32.7 -32735 3.9 ATF1 PKNOX1 ARID4B SIN3A ZNF2 YY1 GLIS2 FOS ZNF263 YY2 DCAF4 PSEN1 ACOT2 DPF3 LOC101928123 ENSG00000206751 GC14M072854
GH14F072903 1.4 FANTOM5 Ensembl ENCODE 16.1 -20.3 -20312 5.2 ATF1 PKNOX1 CREB3L1 WRNIP1 ZNF121 ELK1 ZNF143 FOS KLF13 DEK DCAF4 ELMSAN1 PSEN1 LOC100420966 LOC101928123 DPF3 PAPLN
GH14F072948 0.6 ENCODE 12.4 +22.4 22376 0.2 CTCF ZNF654 TRIM22 ZNF384 REST ATF2 RAD21 ZNF143 SMC3 NBN DCAF4 DPF3 LOC100420966 RPL36P3
GH14F073007 0.6 ENCODE 12.2 +82.4 82370 1.6 HDGF TBX21 YY1 IKZF1 ZNF26 HNF4G ZBTB33 MLLT1 CREM NFE2L2 RBM25 ELMSAN1 DCAF4 LOC100420966 PSEN1 GC14M073010 RPS12P1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DCAF4 on UCSC Golden Path with GeneCards custom track

Promoters for DCAF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000420618 368 2201 HDGF PKNOX1 ATF1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF48

Genomic Location for DCAF4 Gene

Chromosome:
14
Start:
72,926,332 bp from pter
End:
72,962,098 bp from pter
Size:
35,767 bases
Orientation:
Plus strand

Genomic View for DCAF4 Gene

Genes around DCAF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4 Gene

Proteins for DCAF4 Gene

  • Protein details for DCAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WV16-DCAF4_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 4
    Protein Accession:
    Q8WV16
    Secondary Accessions:
    • B4DUT6
    • G3V522
    • Q86U31
    • Q8IV10
    • Q96K22
    • Q9Y4P5

    Protein attributes for DCAF4 Gene

    Size:
    495 amino acids
    Molecular mass:
    55694 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.

    Three dimensional structures from OCA and Proteopedia for DCAF4 Gene

    Alternative splice isoforms for DCAF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF4 Gene

Post-translational modifications for DCAF4 Gene

  • Ubiquitination at Lys 460
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DCAF4 Gene

Domains & Families for DCAF4 Gene

Protein Domains for DCAF4 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WV16

UniProtKB/Swiss-Prot:

DCAF4_HUMAN :
  • Contains 2 WD repeats.
Similarity:
  • Contains 2 WD repeats.
genes like me logo Genes that share domains with DCAF4: view

Function for DCAF4 Gene

Molecular function for DCAF4 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes for DCAF4 Gene

genes like me logo Genes that share phenotypes with DCAF4: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4 Gene

Localization for DCAF4 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF4 Gene COMPARTMENTS Subcellular localization image for DCAF4 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF4 Gene

Pathways & Interactions for DCAF4 Gene

SuperPathways for DCAF4 Gene

No Data Available

UniProtKB/Swiss-Prot Q8WV16-DCAF4_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF4: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF4 Gene

Drugs & Compounds for DCAF4 Gene

(1) Drugs for DCAF4 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
corticosteroids Pharma 0
genes like me logo Genes that share compounds with DCAF4: view

Transcripts for DCAF4 Gene

Unigene Clusters for DCAF4 Gene

DDB1 and CUL4 associated factor 4:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - -
SP5:
SP6:
SP7:

Relevant External Links for DCAF4 Gene

GeneLoc Exon Structure for
DCAF4
ECgene alternative splicing isoforms for
DCAF4

Expression for DCAF4 Gene

mRNA expression in normal human tissues for DCAF4 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF4 Gene:

DCAF4

SOURCE GeneReport for Unigene cluster for DCAF4 Gene:

Hs.331491
genes like me logo Genes that share expression patterns with DCAF4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DCAF4 Gene

Orthologs for DCAF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF4 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
OneToMany
DCAF4 34
  • 86.95 (n)
cow
(Bos Taurus)
Mammalia DCAF4 34
  • 84.45 (n)
WDR21A 35
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dcaf4 34 16 35
  • 83.44 (n)
rat
(Rattus norvegicus)
Mammalia Dcaf4 34
  • 83.23 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 68 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 48 (a)
ManyToMany
-- 35
  • 41 (a)
ManyToMany
chicken
(Gallus gallus)
Aves DCAF4 34
  • 69.11 (n)
-- 35
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf4 34
  • 59.18 (n)
zebrafish
(Danio rerio)
Actinopterygii wdr21 34 35
  • 61.45 (n)
Species where no ortholog for DCAF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4 Gene

ENSEMBL:
Gene Tree for DCAF4 (if available)
TreeFam:
Gene Tree for DCAF4 (if available)

Paralogs for DCAF4 Gene

Paralogs for DCAF4 Gene

(2) SIMAP similar genes for DCAF4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCAF4: view

Variants for DCAF4 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF4 Gene

DCAF4_HUMAN-Q8WV16
An intronic G-to-A transition (rs2535913) has been associated with leukocyte telomere length. The minor A allele is associated with shorter telomeres and lower expression in lymphoblastoid cells and in sun-exposed skin (PubMed:25624462).

Sequence variations from dbSNP and Humsavar for DCAF4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2535913 Uncertain significance 72,948,525(-) TTAGC(C/T)CTCTG intron-variant
rs10130567 -- 72,955,220(+) GAGAT(C/G)GAATG intron-variant
rs10134292 -- 72,934,488(+) TTTCG(C/T)CATGT intron-variant, upstream-variant-2KB
rs10148121 -- 72,935,344(+) CCGCC(A/T)CCTGG intron-variant
rs10149638 -- 72,953,732(+) aaaaa(A/T)atata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF4 Gene

Variant ID Type Subtype PubMed ID
esv3353836 CNV insertion 20981092
esv3892560 CNV gain 25118596
nsv1035460 CNV gain 25217958
nsv1048734 CNV gain 25217958
nsv1049819 CNV gain 25217958

Variation tolerance for DCAF4 Gene

Residual Variation Intolerance Score: 89.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.00; 84.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF4 Gene

Human Gene Mutation Database (HGMD)
DCAF4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF4

Disorders for DCAF4 Gene

Relevant External Links for DCAF4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF4

No disorders were found for DCAF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF4 Gene

Publications for DCAF4 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 3 4 64
  2. DCAF4, a novel gene associated with leucocyte telomere length. (PMID: 25624462) Mangino M. … Aviv A. (J. Med. Genet. 2015) 3 4 64
  3. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DCAF4 Gene

Sources for DCAF4 Gene

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