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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCAF4 Gene

protein-coding   GIFtS: 44
GCID: GC14P073393

DDB1 And CUL4 Associated Factor 4

(Previous names: WD repeat domain 21, WD repeat domain 21A)
(Previous symbols: WDR21, WDR21A)
  Search for DCAF4
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DDB1 And CUL4 Associated Factor 41 2     WD Repeat-Containing Protein 21A2 3
WDR211 2 3     WD Repeat Domain 211
WDR21A1 2 3     DDB1- And CUL4-Associated Factor 42
WD Repeat Domain 21A1 2     

External Ids:    HGNC: 202291   Entrez Gene: 260942   Ensembl: ENSG000001195997   UniProtKB: Q8WV163   

Export aliases for DCAF4 gene to outside databases

Previous GC identifers: GC14P072464 GC14P053559


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCAF4 Gene:
This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular
complex. Multiple alternatively spliced transcript variants have been found for this gene. (provided by RefSeq,
Jul 2009)

GeneCards Summary for DCAF4 Gene: 
DCAF4 (DDB1 and CUL4 associated factor 4) is a protein-coding gene. An important paralog of this gene is DCAF4L1.

UniProtKB/Swiss-Prot: DCAF4_HUMAN, Q8WV16
Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DCAF4
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCAF4 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCAF4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.2   HGNC cytogenetic band: 14q24.3

DCAF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF4 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P073393:  view genomic region     (about GC identifiers)

Start:
73,393,040 bp from pter      End:
73,426,411 bp from pter
Size:
33,372 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCAF4_HUMAN, Q8WV16 (See protein sequence)
Recommended Name: DDB1- and CUL4-associated factor 4  
Size: 495 amino acids; 55694 Da
Subunit: Interacts with DDB1 and CUL4A
1 PDB 3D structure from and Proteopedia for DCAF4:
3I8C (3D)    
Secondary accessions: B4DUT6 G3V522 Q86U31 Q8IV10 Q96K22 Q9Y4P5
Alternative splicing: 5 isoforms:  Q8WV16-1   Q8WV16-2   Q8WV16-3   Q8WV16-4   Q8WV16-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCAF4: NX_Q8WV16

Explore proteomics data for DCAF4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WV16

  • DCAF4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCAF4 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001156980.1  NP_001156981.1  NP_056419.2  NP_851937.1  NP_851938.2  

    ENSEMBL proteins: 
     ENSP00000351147   ENSP00000345176   ENSP00000422270   ENSP00000377781   ENSP00000426178  
     ENSP00000452131   ENSP00000451186  

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    Cloud-Clone Corp. Proteins for DCAF4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0080008Cul4-RING ubiquitin ligase complex IDA16949367

    DCAF4 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    3 InterPro protein domains:
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8WV16

    ProtoNet protein and cluster: Q8WV16

    UniProtKB/Swiss-Prot: DCAF4_HUMAN, Q8WV16
    Similarity: Contains 2 WD repeats


    DCAF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCAF4_HUMAN, Q8WV16
    Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    DCAF4 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: DCAF4_HUMAN, Q8WV16
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCAF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/24 Interacting proteins for DCAF4 (Q8WV163 ENSP000003511474) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=1 STRING: ENSP00000350512
    COPS6Q7L5N13, ENSP000003041024I2D: score=1 STRING: ENSP00000304102
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    CUL4AQ136193, ENSP000003645894I2D: score=1 STRING: ENSP00000364589
    USP7Q930093, ENSP000003435354I2D: score=1 STRING: ENSP00000343535
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    DCAF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCAF4

    Search CenterWatch for drugs/clinical trials and news about DCAF4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCAF4 gene (5 alternative transcripts): 
    NM_001163508.1  NM_001163509.1  NM_015604.3  NM_181340.2  NM_181341.2  

    Unigene Cluster for DCAF4:

    DDB1 and CUL4 associated factor 4
    Hs.331491  [show with all ESTs]
    Unigene Representative Sequence: AL080157
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000358377 ENST00000353777(uc001xni.3) ENST00000509320 ENST00000394234(uc001xnh.3)
    ENST00000509153 ENST00000555042(uc010ttr.2 uc001xnj.3 uc001xng.3 uc010tts.2 uc010ttt.2)
    ENST00000514191 ENST00000505361 ENST00000510612 ENST00000508412 ENST00000514486
    ENST00000553457(uc001xnk.3) ENST00000513337 ENST00000557203 ENST00000555992

    miRNA
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    hsa-miR-558 hsa-miR-3202 hsa-miR-4263 hsa-miR-1299
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK027745.1 AK297571.1 AK297742.1 AK300786.1 AK315499.1 AL080157.1 BC018979.2 BC035901.1 
    BX161489.1 BX247962.1 

    11 DOTS entries:

    DT.412533  DT.97842484  DT.100791060  DT.100791058  DT.100791056  DT.100791062  DT.120755476  DT.65286008 
    DT.86859093  DT.91841531  DT.40302320 

    24/119 AceView cDNA sequences (see all 119):

    BM468150 BC035901 BX283926 AW167878 BM988680 AI797602 BE250235 BM129489 
    BM973774 C02546 NM_015604 AW438829 AW250072 AI686444 BI963764 BM141687 
    BI915515 BX161489 BM761316 AI038805 BM811013 BP351303 NM_181340 BM824382 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
    SP1:                                      -     -                                   -                                       
    SP2:              -                       -     -                                   -                                       
    SP3:                                                                                -                                       
    SP4:                                -     -     -     -                 -     -     -     -     -                           
    SP5:                                                                                                                        


    ECgene alternative splicing isoforms for DCAF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCAF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTTTGTTCA
    DCAF4 Expression
    About this image


    See DCAF4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCAF4

    SOURCE GeneReport for Unigene cluster: Hs.331491
        SABiosciences Custom PCR Arrays for DCAF4
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DCAF4 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcaf41 , 5 DDB1 and CUL4 associated factor 41, 5 82.93(n)1
    80.97(a)1
      12 (38.75 cM)5
    738281  NM_001165256.11  NP_001158728.11 
     835204665 
    chicken
    (Gallus gallus)
    Aves DCAF41 DDB1 and CUL4 associated factor 4 67.28(n)
    67.28(a)
      423253  XM_421173.3  XP_421173.3 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    56(a)
    1 → many
    1(38835561-38851154)
    zebrafish
    (Danio rerio)
    Actinopterygii wdr212 WD repeat domain 21 73.66(n)   393674  AY423032.1 


    ENSEMBL Gene Tree for DCAF4 (if available)
    TreeFam Gene Tree for DCAF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DCAF4 gene
    DCAF4L12  DCAF4L22  
    2 SIMAP similar genes for DCAF4 using alignment to 4 protein entries:     DCAF4_HUMAN (see all proteins):
    DCAF4L1    DCAF4L2

    DCAF4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/884 SNPs in DCAF4 are shown (see all 884)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1486768751,2
    --73391060(+) CTCAGC/TAGATG 5 -- us2k10--------
    rs1855342591,2
    --73391100(+) CTGAGA/GTTGGA 5 -- us2k10--------
    rs1423385581,2
    C--73391132(+) GCCCAA/GCAAGC 5 -- us2k10--------
    rs1149581271,2
    C,F--73391263(+) TGGCCG/AGCTGC 5 -- us2k11Minor allele frequency- A:0.07WA 118
    rs1900220021,2
    --73391264(+) GGCCGC/GCTGCC 5 -- us2k10--------
    rs1427805431,2
    C--73391302(+) GCCAA-/CTCCTCCT 5 -- us2k10--------
    rs104838511,2
    C,F,H--73391340(+) CTCTTC/TAGTGG 5 -- us2k1 tfbs3105Minor allele frequency- T:0.06NS EA NA PA EU CA WA CSA 6855
    rs1508612171,2
    C--73391404(+) AATTCC/TGCCTC 5 -- us2k10--------
    rs1392433261,2
    C--73391478(+) AAGGAC/TTGTTG 5 -- us2k10--------
    rs1836256831,2
    --73391524(+) TCCACA/GATCTT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for DCAF4 (73393040 - 73426411 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DCAF4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv274200CNV Insertion20981092


    Human Gene Mutation Database (HGMD): DCAF4
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DCAF4 for disorders           About MalaCards

    DCAF4 for disorders           About GeneDecksing


    Export disorders for DCAF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCAF4 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with DCAF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    5. Association between WDR21A polymorphisms and airway re sponsiveness to inhaled corticosteroids in asthmatic patients. (PubMed id 22366774)1 Cho S.H....Park C.S. (2012)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 26094 HGNC: 20229 AceView: WDR21 Ensembl:ENSG00000119599 euGenes: HUgn26094
    ECgene: DCAF4 H-InvDB: DCAF4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCAF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCAF4 gene:
    Search GeneIP for patents involving DCAF4

    GeneCards and IP:
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