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Aliases for DCAF4 Gene

Aliases for DCAF4 Gene

  • DDB1 And CUL4 Associated Factor 4 2 3
  • WD Repeat-Containing Protein 21A 3 4
  • WD Repeat Domain 21A 2 3
  • WDR21A 3 4
  • WDR21 3 4
  • DDB1- And CUL4-Associated Factor 4 3
  • WD Repeat Domain 21 2

External Ids for DCAF4 Gene

Previous HGNC Symbols for DCAF4 Gene

  • WDR21
  • WDR21A

Previous GeneCards Identifiers for DCAF4 Gene

  • GC14P072464
  • GC14P073393
  • GC14P053559

Summaries for DCAF4 Gene

Entrez Gene Summary for DCAF4 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF4 Gene

DCAF4 (DDB1 And CUL4 Associated Factor 4) is a Protein Coding gene. An important paralog of this gene is DCAF4L1.

UniProtKB/Swiss-Prot for DCAF4 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF4 Gene

Genomics for DCAF4 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAF4 Gene

72,926,332 bp from pter
72,962,103 bp from pter
35,772 bases
Plus strand

Genomic View for DCAF4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF4 Gene

No data available for Regulatory Elements for DCAF4 Gene

Proteins for DCAF4 Gene

  • Protein details for DCAF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 4
    Protein Accession:
    Secondary Accessions:
    • B4DUT6
    • G3V522
    • Q86U31
    • Q8IV10
    • Q96K22
    • Q9Y4P5

    Protein attributes for DCAF4 Gene

    495 amino acids
    Molecular mass:
    55694 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.

    Three dimensional structures from OCA and Proteopedia for DCAF4 Gene

    Alternative splice isoforms for DCAF4 Gene


neXtProt entry for DCAF4 Gene

Proteomics data for DCAF4 Gene at MOPED

Post-translational modifications for DCAF4 Gene

  • Ubiquitination at Lys460
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DCAF4 Gene

Domains for DCAF4 Gene

Protein Domains for DCAF4 Gene

Suggested Antigen Peptide Sequences for DCAF4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 2 WD repeats.
  • Contains 2 WD repeats.
genes like me logo Genes that share domains with DCAF4: view

Function for DCAF4 Gene

Molecular function for DCAF4 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF4: view

Animal Model Products

miRNA for DCAF4 Gene

miRTarBase miRNAs that target DCAF4

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF4 Gene

Localization for DCAF4 Gene

Subcellular locations from

Jensen Localization Image for DCAF4 Gene COMPARTMENTS Subcellular localization image for DCAF4 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF4: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF4 Gene

Pathways for DCAF4 Gene

SuperPathways for DCAF4 Gene

No Data Available

UniProtKB/Swiss-Prot Q8WV16-DCAF4_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF4: view

No data available for Pathways by source for DCAF4 Gene

Drugs for DCAF4 Gene

(1) PharmGKB related drug/compound annotations for DCAF4 Gene

Drug/compound Annotation
corticosteroids Clinical Annotation
genes like me logo Genes that share compounds with DCAF4: view

Transcripts for DCAF4 Gene

Unigene Clusters for DCAF4 Gene

DDB1 and CUL4 associated factor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18
SP1: - - -
SP2: - - - -
SP3: -
SP4: - - - - - - - - -

Relevant External Links for DCAF4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF4 Gene

mRNA expression in normal human tissues for DCAF4 Gene

SOURCE GeneReport for Unigene cluster for DCAF4 Gene Hs.331491

genes like me logo Genes that share expressions with DCAF4: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for DCAF4 Gene

Orthologs for DCAF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DCAF4 35
  • 84.45 (n)
  • 81.54 (a)
WDR21A 36
  • 81 (a)
(Canis familiaris)
Mammalia DCAF4 35
  • 86.95 (n)
  • 87.42 (a)
-- 36
  • 87 (a)
(Mus musculus)
Mammalia Dcaf4 35
  • 83.44 (n)
  • 81.97 (a)
Dcaf4 16
Dcaf4 36
  • 77 (a)
(Pan troglodytes)
Mammalia DCAF4 35
  • 99.53 (n)
  • 99.39 (a)
DCAF4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Dcaf4 35
  • 83.23 (n)
  • 82.39 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 68 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 48 (a)
-- 36
  • 41 (a)
(Gallus gallus)
Aves DCAF4 35
  • 69.11 (n)
  • 69.4 (a)
-- 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf4 35
  • 59.18 (n)
  • 52.48 (a)
(Danio rerio)
Actinopterygii wdr21 35
  • 61.45 (n)
  • 59.88 (a)
wdr21 36
  • 58 (a)
Species with no ortholog for DCAF4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF4 Gene

Gene Tree for DCAF4 (if available)
Gene Tree for DCAF4 (if available)

Paralogs for DCAF4 Gene

Paralogs for DCAF4 Gene

(2) SIMAP similar genes for DCAF4 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DCAF4: view

Variants for DCAF4 Gene

Sequence variations from dbSNP and Humsavar for DCAF4 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1110058 -- 72,957,584(-) AAATC(C/G)ACTTA intron-variant
rs2098321 -- 72,927,414(-) AGATC(A/G)TGCCA intron-variant
rs2098322 -- 72,926,576(-) ATCGA(C/T)GCCAG intron-variant, upstream-variant-2KB
rs2240980 -- 72,942,975(+) TGCCC(C/G)CACCC intron-variant
rs2240981 -- 72,943,490(+) TGCAG(C/T)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF4 Gene

Variant ID Type Subtype PubMed ID
esv274200 CNV Insertion 20981092

Relevant External Links for DCAF4 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF4 Gene

Disorders for DCAF4 Gene

No disorders were found for DCAF4 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for DCAF4 Gene

Publications for DCAF4 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4
  4. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for DCAF4 Gene

Sources for DCAF4 Gene

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