Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DCAF17 Gene

Aliases for DCAF17 Gene

  • DDB1 And CUL4 Associated Factor 17 2 3
  • C2orf37 3 4
  • DDB1- And CUL4-Associated Factor 17 3
  • Chromosome 2 Open Reading Frame 37 2
  • Woodhouse-Sakati Syndrome 2
  • C20orf37 6

External Ids for DCAF17 Gene

Previous Symbols for DCAF17 Gene

  • C2orf37

Summaries for DCAF17 Gene

Entrez Gene Summary for DCAF17 Gene

  • This gene encodes a nuclear transmembrane protein that associates with cullin 4A/damaged DNA binding protein 1 ubiquitin ligase complex. Mutations in this gene are associated with Woodhouse-Sakati syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

GeneCards Summary for DCAF17 Gene

DCAF17 (DDB1 And CUL4 Associated Factor 17) is a Protein Coding gene. Diseases associated with DCAF17 include woodhouse-sakati syndrome and hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome.

UniProtKB/Swiss-Prot for DCAF17 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Wiki entry for DCAF17 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF17 Gene

Genomics for DCAF17 Gene

Genomic Location for DCAF17 Gene

Start:
171,434,217 bp from pter
End:
171,485,052 bp from pter
Size:
50,836 bases
Orientation:
Plus strand

Genomic View for DCAF17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF17 Gene

No data available for Regulatory Elements for DCAF17 Gene

Proteins for DCAF17 Gene

  • Protein details for DCAF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5H9S7-DCA17_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 17
    Protein Accession:
    Q5H9S7
    Secondary Accessions:
    • B2RTW5
    • Q53TN3
    • Q9H908

    Protein attributes for DCAF17 Gene

    Size:
    520 amino acids
    Molecular mass:
    58778 Da
    Quaternary structure:
    • Interacts with DDB1, CUL4A and CUL4B.

    Alternative splice isoforms for DCAF17 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF17 Gene

Proteomics data for DCAF17 Gene at MOPED

Post-translational modifications for DCAF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF17 Gene

No data available for DME Specific Peptides for DCAF17 Gene

Domains for DCAF17 Gene

Gene Families for DCAF17 Gene

HGNC:
  • DCAF :DDB1 and CUL4 associated factors

Protein Domains for DCAF17 Gene

ProtoNet:
genes like me logo Genes that share domains with DCAF17: view

No data available for UniProtKB/Swiss-Prot for DCAF17 Gene

Function for DCAF17 Gene

Molecular function for DCAF17 Gene

UniProtKB/Swiss-Prot Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

miRNA for DCAF17 Gene

miRTarBase miRNAs that target DCAF17

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF17 Gene

Localization for DCAF17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF17 Gene

Membrane; Multi-pass membrane protein. Nucleus, nucleolus. Note=According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF17 Gene COMPARTMENTS Subcellular localization image for DCAF17 gene
Compartment Confidence
nucleus 5
mitochondrion 2
cytosol 1
extracellular 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCAF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IEA --
GO:0016021 integral component of membrane IEA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF17: view

Pathways for DCAF17 Gene

SuperPathways for DCAF17 Gene

No Data Available

UniProtKB/Swiss-Prot Q5H9S7-DCA17_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF17: view

No data available for Pathways by source for DCAF17 Gene

Transcripts for DCAF17 Gene

Unigene Clusters for DCAF17 Gene

DDB1 and CUL4 associated factor 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF17 Gene

No ASD Table

Relevant External Links for DCAF17 Gene

GeneLoc Exon Structure for
DCAF17
ECgene alternative splicing isoforms for
DCAF17

Expression for DCAF17 Gene

mRNA expression in normal human tissues for DCAF17 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DCAF17 Gene

SOURCE GeneReport for Unigene cluster for DCAF17 Gene Hs.659439

mRNA Expression by UniProt/SwissProt for DCAF17 Gene

Q5H9S7-DCA17_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with DCAF17: view

Orthologs for DCAF17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DCAF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF17 36
  • 99.68 (n)
  • 99.42 (a)
DCAF17 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCAF17 36
  • 88.84 (n)
  • 86.25 (a)
DCAF17 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF17 36
  • 93.9 (n)
  • 92.87 (a)
DCAF17 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf17 36
  • 89.64 (n)
  • 90.93 (a)
Dcaf17 16
Dcaf17 37
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAF17 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF17 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf17 36
  • 89.43 (n)
  • 91.12 (a)
chicken
(Gallus gallus)
Aves DCAF17 36
  • 74.4 (n)
  • 74.85 (a)
DCAF17 37
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF17 37
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf17 36
  • 66.87 (n)
  • 64.8 (a)
zebrafish
(Danio rerio)
Actinopterygii dcaf17 36
  • 59.27 (n)
  • 52.02 (a)
dcaf17 37
  • 49 (a)
OneToOne
Species with no ortholog for DCAF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF17 Gene

ENSEMBL:
Gene Tree for DCAF17 (if available)
TreeFam:
Gene Tree for DCAF17 (if available)

Paralogs for DCAF17 Gene

genes like me logo Genes that share paralogs with DCAF17: view

No data available for Paralogs for DCAF17 Gene

Variants for DCAF17 Gene

Sequence variations from dbSNP and Humsavar for DCAF17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs888428 -- 171,483,454(-) AGAAT(A/G)CAGAA utr-variant-3-prime, nc-transcript-variant
rs997666 -- 171,452,567(+) TCTCA(C/T)GTCAC intron-variant
rs1185477 -- 171,462,586(-) GAAAG(C/T)GCCTA intron-variant
rs1476111 -- 171,452,100(-) CCTTC(C/G)AAAGG intron-variant
rs1558936 -- 171,471,940(-) cctct(C/T)ggcct intron-variant

Relevant External Links for DCAF17 Gene

HapMap Linkage Disequilibrium report
DCAF17
Human Gene Mutation Database (HGMD)
DCAF17

No data available for Structural Variations from Database of Genomic Variants (DGV) for DCAF17 Gene

Disorders for DCAF17 Gene

(1) OMIM Diseases for DCAF17 Gene (612515)

UniProtKB/Swiss-Prot

DCA17_HUMAN
  • Woodhouse-Sakati syndrome (WoSaS) [MIM:241080]: Rare autosomal recessive disorder characterized by hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome. {ECO:0000269 PubMed:19026396}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for DCAF17 Gene

genes like me logo Genes that share disorders with DCAF17: view

Publications for DCAF17 Gene

  1. Mutations in C2orf37, encoding a nucleolar protein, cause hypogonadism, alopecia, diabetes mellitus, mental retardation, and extrapyramidal syndrome. (PMID: 19026396) Alazami A.M. … Alkuraya F.S. (Am. J. Hum. Genet. 2008) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4
  4. DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. (PMID: 17588513) Lee J. … Zhou P. (Mol. Cell 2007) 3
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3

Products for DCAF17 Gene

Sources for DCAF17 Gene

Back to Top

Content