DCAF16 Gene
protein-coding GIFtS: 41
GCID: GC04M017802
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|
DDB1 and CUL4 associated factor 16(Previous name: chromosome 4 open reading frame 30 )
(Previous symbol: C4orf30)
| |
Aliases
for DCAF16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DDB1 And CUL4 Associated Factor 161 2 | | C4orf301 2 3 | | FLJ202801 | | Chromosome 4 Open Reading Frame 301 | | DDB1- And CUL4-Associated Factor 162 |
Export aliases for DCAF16 gene to outside databasesPrevious GC identifers: GC04M017412 GC04M017157 |
Summaries
for DCAF16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DCA16_HUMAN, Q9NXF7Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
|
Genomic Views
for DCAF16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006316.16
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DCAF16
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCAF16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p15.31 Ensembl cytogenetic band: 4p15.31 HGNC cytogenetic band: 4p15.32DCAF16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M017802: view genomic region
(about GC identifiers)
Start:
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17,802,278 bp from pter |
End:
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17,812,381 bp from pter |
Size:
|
10,104 bases |
Orientation:
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minus strand |
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Proteins
for DCAF16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCA16_HUMAN, Q9NXF7 (See
protein sequence)Recommended Name: DDB1- and CUL4-associated factor 16 Size: 216 amino acids; 24193 Da
Subunit: Interacts with DDB1 and CUL4AExplore the universe of human proteins at neXtProt for DCAF16: NX_Q9NXF7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXF7
DCAF16 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060211.3
ENSEMBL proteins: ENSP00000371682 ENSP00000445736
Human Recombinant Protein Products for DCAF16:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0080008 | Cul4-RING ubiquitin ligase complex |
IDA | 16949367 |
DCAF16 for ontologies About GeneDecksing
DCAF16 Antibody Products:
Assay Products for DCAF16: |
Protein
Domains /
Families
for DCAF16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NXF7 |
Function
for DCAF16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DCA16_HUMAN, Q9NXF7Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
DCAF16 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for DCAF16:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF16
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DCAF16 (NM_017741) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAF16 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF16 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF16 |
|
Pathways & Interactions
for DCAF16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: DCA16_HUMAN, Q9NXF7Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCAF16
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/22 Interacting proteins for DCAF16 (Q9NXF71, 3 ENSP000003716824) via UniProtKB, MINT, STRING, and/or I2D (see all 22) About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- |
DCAF16 for ontologies About GeneDecksing
|
Drugs & Compounds
for DCAF16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCAF16
Search CenterWatch for drugs/clinical trials and news about DCAF16 / DCA16
|
Transcripts
for DCAF16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCAF16 gene: NM_017741.3 Unigene Cluster for DCAF16: DDB1 and CUL4 associated factor 16 Hs.614787 [show with all ESTs]Unigene Representative Sequence: NM_0177414 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000382247(uc003gpn.3) ENST00000507768 ENST00000507731 ENST00000536863
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF16
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF16
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCAF16 (NM_017741) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAF16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF16 |
Additional cDNA sequence: AK000287.1 AK056116.1 BC014536.1 BC050697.1 BC068025.1 BC101716.1 BC101718.1 16 DOTS entries: DT.95263485 DT.439477 DT.100775274 DT.121231949 DT.121643961 DT.411980 DT.65285185 DT.100660658 DT.100724766 DT.97763789 DT.100835789 DT.121231897 DT.40312017 DT.86839231 DT.405579 DT.95263484 24/119 AceView cDNA sequences (see all 119): BF475710 BM834212 AW304014 AA347761 BF446389 AK000287 BF224074 BE645684 BU157289 CA443415 AW295611 BQ574204 AI890343 BX117617 AW294072 BU192544 BX954458 BQ438880 BX473060 BC050697 AW268157 BC068025 AA345188 BU616670
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DCAF16 (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | · | 4e | · | 4f |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DCAF16
|
Expression
for DCAF16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCAF16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGCATTTT
About this image
See DCAF16 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCAF16
SOURCE GeneReport for Unigene cluster: Hs.614787
SABiosciences Custom PCR Arrays for DCAF16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAF16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DCAF16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAF16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAF16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF16 |
Orthologs
for DCAF16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for DCAF16 (if available)
TreeFam Gene Tree for DCAF16 (if available) |
Paralogs
for DCAF16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DCAF16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 4 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCAF16 (17802278 - 17812381 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DCAF16
1 CNV: 98637 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for DCAF16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DCAF16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCAF16 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with DCAF16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
|
External Searches for DCAF16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCAF16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCAF16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCAF16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCAF16 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCAF16 gene:
Search GeneIP for patents involving DCAF16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCAF16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DCAF16 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCAF16 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAF16 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DCAF16 | | OriGene 3'-UTR Clone for DCAF16 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF16 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF16 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCAF16 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAF16 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF16 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCAF16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAF16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAF16 |
| |
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| | | | Search Tocris compounds for DCAF16 |
| |  |  |  |  | | | | |
 |
 |
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 | | | DCAF16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF16 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for DCAF16 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF16 |
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