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Aliases for DCAF16 Gene

Aliases for DCAF16 Gene

  • DDB1 And CUL4 Associated Factor 16 2 3
  • C4orf30 3 4
  • Chromosome 4 Open Reading Frame 30 2

External Ids for DCAF16 Gene

Previous HGNC Symbols for DCAF16 Gene

  • C4orf30

Previous GeneCards Identifiers for DCAF16 Gene

  • GC04M017412
  • GC04M017157

Summaries for DCAF16 Gene

GeneCards Summary for DCAF16 Gene

DCAF16 (DDB1 And CUL4 Associated Factor 16) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCAF16 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF16 Gene

Genomics for DCAF16 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAF16 Gene

Chromosome:
4
Start:
17,800,655 bp from pter
End:
17,810,769 bp from pter
Size:
10,115 bases
Orientation:
Minus strand

Genomic View for DCAF16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF16 Gene

No data available for Regulatory Elements for DCAF16 Gene

Proteins for DCAF16 Gene

  • Protein details for DCAF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXF7-DCA16_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 16
    Protein Accession:
    Q9NXF7
    Secondary Accessions:
    • B3KPB7

    Protein attributes for DCAF16 Gene

    Size:
    216 amino acids
    Molecular mass:
    24193 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.

neXtProt entry for DCAF16 Gene

Proteomics data for DCAF16 Gene at MOPED

Post-translational modifications for DCAF16 Gene

  • Ubiquitination at Lys 79 and Lys 150
  • Modification sites at PhosphoSitePlus

Other Protein References for DCAF16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF16 Gene

Domains & Families for DCAF16 Gene

Gene Families for DCAF16 Gene

Protein Domains for DCAF16 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DCAF16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF16: view

No data available for UniProtKB/Swiss-Prot for DCAF16 Gene

Function for DCAF16 Gene

Molecular function for DCAF16 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with DCAF16: view
genes like me logo Genes that share phenotypes with DCAF16: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF16 Gene

Localization for DCAF16 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF16 Gene COMPARTMENTS Subcellular localization image for DCAF16 gene
Compartment Confidence
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF16 Gene

Pathways & Interactions for DCAF16 Gene

SuperPathways for DCAF16 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NXF7-DCA16_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF16: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF16 Gene

Drugs & Compounds for DCAF16 Gene

No Compound Related Data Available

Transcripts for DCAF16 Gene

Unigene Clusters for DCAF16 Gene

DDB1 and CUL4 associated factor 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF16

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7:

Relevant External Links for DCAF16 Gene

GeneLoc Exon Structure for
DCAF16
ECgene alternative splicing isoforms for
DCAF16

Expression for DCAF16 Gene

mRNA expression in normal human tissues for DCAF16 Gene

Protein differential expression in normal tissues from HIPED for DCAF16 Gene

This gene is overexpressed in Ovary (39.8), Testis (10.4), NK cells (8.2), and CD8 Tcells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF16 Gene



SOURCE GeneReport for Unigene cluster for DCAF16 Gene Hs.614787

genes like me logo Genes that share expression patterns with DCAF16: view

Protein tissue co-expression partners for DCAF16 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAF16 Gene

Orthologs for DCAF16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DCAF16 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DCAF16 35
  • 92.28 (n)
  • 94.44 (a)
cow
(Bos Taurus)
Mammalia DCAF16 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCAF16 36
  • 100 (a)
OneToOne
Species with no ortholog for DCAF16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCAF16 Gene

ENSEMBL:
Gene Tree for DCAF16 (if available)
TreeFam:
Gene Tree for DCAF16 (if available)

Paralogs for DCAF16 Gene

No data available for Paralogs for DCAF16 Gene

Variants for DCAF16 Gene

Sequence variations from dbSNP and Humsavar for DCAF16 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
VAR_034917 -
VAR_034918 -

Structural Variations from Database of Genomic Variants (DGV) for DCAF16 Gene

Variant ID Type Subtype PubMed ID
nsv878721 CNV Loss 21882294
esv2645526 CNV Deletion 19546169

Variation tolerance for DCAF16 Gene

Residual Variation Intolerance Score: 48.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.89; 59.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF16 Gene

HapMap Linkage Disequilibrium report
DCAF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF16 Gene

Disorders for DCAF16 Gene

Relevant External Links for DCAF16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF16
genes like me logo Genes that share disorders with DCAF16: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF16 Gene

Publications for DCAF16 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 67
  4. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M. … Stelzl U. (Nat. Methods 2013) 67
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 67

Products for DCAF16 Gene

Sources for DCAF16 Gene

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