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Aliases for DCAF16 Gene

Aliases for DCAF16 Gene

  • DDB1 And CUL4 Associated Factor 16 2 3
  • C4orf30 3 4
  • DDB1- And CUL4-Associated Factor 16 3
  • Chromosome 4 Open Reading Frame 30 2

External Ids for DCAF16 Gene

Previous Symbols for DCAF16 Gene

  • C4orf30

Summaries for DCAF16 Gene

GeneCards Summary for DCAF16 Gene

DCAF16 (DDB1 And CUL4 Associated Factor 16) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCAF16 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF16 Gene

Genomics for DCAF16 Gene

Genomic Location for DCAF16 Gene

17,800,655 bp from pter
17,810,763 bp from pter
10,109 bases
Minus strand

Genomic View for DCAF16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF16 Gene

No data available for Regulatory Elements for DCAF16 Gene

Proteins for DCAF16 Gene

  • Protein details for DCAF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 16
    Protein Accession:
    Secondary Accessions:
    • B3KPB7

    Protein attributes for DCAF16 Gene

    216 amino acids
    Molecular mass:
    24193 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.

neXtProt entry for DCAF16 Gene

Proteomics data for DCAF16 Gene at MOPED

Post-translational modifications for DCAF16 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys79 and Lys150

Other Protein References for DCAF16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DCAF16 Gene

Domains for DCAF16 Gene

Gene Families for DCAF16 Gene

  • DCAF :DDB1 and CUL4 associated factors

Protein Domains for DCAF16 Gene

genes like me logo Genes that share domains with DCAF16: view

No data available for UniProtKB/Swiss-Prot for DCAF16 Gene

Function for DCAF16 Gene

Molecular function for DCAF16 Gene

UniProtKB/Swiss-Prot Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with DCAF16: view

Phenotypes for DCAF16 Gene

GenomeRNAi human phenotypes for DCAF16:
genes like me logo Genes that share phenotypes with DCAF16: view

miRNA for DCAF16 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF16 Gene

Localization for DCAF16 Gene

Subcellular locations from

Jensen Localization Image for DCAF16 Gene COMPARTMENTS Subcellular localization image for DCAF16 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF16: view

Pathways for DCAF16 Gene

SuperPathways for DCAF16 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NXF7-DCA16_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF16: view

No data available for Pathways by source for DCAF16 Gene

Transcripts for DCAF16 Gene

Unigene Clusters for DCAF16 Gene

DDB1 and CUL4 associated factor 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF16 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c · 4d · 4e · 4f
SP1: -
SP2: - -
SP3: - - -
SP4: - - -
SP5: - - -
SP6: - - - -

Relevant External Links for DCAF16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF16 Gene

mRNA expression in normal human tissues for DCAF16 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF16 Gene

SOURCE GeneReport for Unigene cluster for DCAF16 Gene Hs.614787

genes like me logo Genes that share expressions with DCAF16: view

Orthologs for DCAF16 Gene

This gene was present in the common ancestor of mammals.

Orthologs for DCAF16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF16 37
  • 100 (a)
(Bos Taurus)
Mammalia DCAF16 37
  • 95 (a)
(Canis familiaris)
Mammalia DCAF16 36
  • 92.28 (n)
  • 94.44 (a)
Species with no ortholog for DCAF16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCAF16 Gene

Gene Tree for DCAF16 (if available)
Gene Tree for DCAF16 (if available)

Paralogs for DCAF16 Gene

No data available for Paralogs for DCAF16 Gene

Variants for DCAF16 Gene

Sequence variations from dbSNP and Humsavar for DCAF16 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1135724 -- 17,805,382(-) ttaat(A/G)tactg intron-variant
rs1304452 -- 17,808,159(-) GTTTC(C/T)TTTAT intron-variant
rs2286539 -- 17,808,632(-) TATTT(C/T)GGTTA intron-variant
rs2286540 -- 17,807,915(-) AGAAA(C/T)ACTCA intron-variant
rs3178753 -- 17,803,224(-) AACAC(A/G)GTGAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DCAF16 Gene

Variant ID Type Subtype PubMed ID
nsv878721 CNV Loss 21882294
esv2645526 CNV Deletion 19546169

Relevant External Links for DCAF16 Gene

HapMap Linkage Disequilibrium report

Disorders for DCAF16 Gene

No disorders were found for DCAF16 Gene.

No data available for UniProtKB/Swiss-Prot for DCAF16 Gene

Publications for DCAF16 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4
  4. An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PMID: 19295130) Olma M.H. … Pintard L. (J. Cell. Sci. 2009) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for DCAF16 Gene

Sources for DCAF16 Gene

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