DCAF15 Gene
protein-coding GIFtS: 38
GCID: GC19P014063
|
|
DDB1 and CUL4 associated factor 15(Previous name: chromosome 19 open reading frame 72 )
(Previous symbol: C19orf72)
| |
Aliases
for DCAF15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DDB1 And CUL4 Associated Factor 151 2 | | C19orf721 2 3 | | MGC994811 | | Chromosome 19 Open Reading Frame 721 | | DDB1- And CUL4-Associated Factor 152 |
Export aliases for DCAF15 gene to outside databasesPrevious GC identifers: GC19P013927 GC19P013634 |
Summaries
for DCAF15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DCA15_HUMAN, Q66K64Function: May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase
|
Genomic Views
for DCAF15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DCAF15
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCAF15
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF15 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.12 Ensembl cytogenetic band: 19p13.12 HGNC cytogenetic band: 19p13.12DCAF15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P014063: view genomic region
(about GC identifiers)
Start:
|
14,063,304 bp from pter |
End:
|
14,072,256 bp from pter |
Size:
|
8,953 bases |
Orientation:
|
plus strand |
|
Proteins
for DCAF15 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCA15_HUMAN, Q66K64 (See
protein sequence)Recommended Name: DDB1- and CUL4-associated factor 15 Size: 600 amino acids; 66463 Da
Subunit: Interacts with DDB1 and CUL4A
Sequence caution: Sequence=AAH13280.2; Type=Frameshift; Positions=89;
Secondary accessions: B3KS86 Q96DW0 Q9BU31Explore the universe of human proteins at neXtProt for DCAF15: NX_Q66K64
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q66K64
DCAF15 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612362.2
ENSEMBL proteins: ENSP00000254337 ENSP00000466932 ENSP00000466048 ENSP00000468330
Human Recombinant Protein Products:
DCAF15 Antibody Products:
Assay Products for DCAF15: |
Protein
Domains /
Families
for DCAF15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q66K64 |
Function
for DCAF15 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DCA15_HUMAN, Q66K64Function: May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DCAF15 (NM_138353) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAF15 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF15 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF15 |
|
Pathways & Interactions
for DCAF15 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: DCA15_HUMAN, Q66K64Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCAF15
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for DCAF15 (Q66K643 ENSP000002543374) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- |
DCAF15 for ontologies About GeneDecksing
|
Drugs & Compounds
for DCAF15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCAF15
Search CenterWatch for drugs/clinical trials and news about DCAF15 / DCA15
|
Transcripts
for DCAF15 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCAF15 gene: NM_138353.2 Unigene Cluster for DCAF15: DDB1 and CUL4 associated factor 15 Hs.443636 [show with all ESTs]Unigene Representative Sequence: BC0805756 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000254337(uc002mxt.3 uc002mxu.3) ENST00000591802 ENST00000585468
ENST00000587307 ENST00000588523 ENST00000591385
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF15 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF15 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCAF15 (NM_138353) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAF15 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF15 |
Additional cDNA sequence: AK093072.1 BC002926.2 BC013280.2 BC018894.2 BC018895.2 BC068994.1 BC080575.1 11 DOTS entries: DT.95280368 DT.121473932 DT.100782445 DT.121473881 DT.444643 DT.425198 DT.95280373 DT.206207 DT.86843890 DT.95280375 DT.97763790 24/185 AceView cDNA sequences (see all 185): BM692362 AA723270 CD366712 BC013280 AA732167 AI363375 AI809878 AI357352 BU501846 BX096234 AI149532 BF055149 AW206903 AA425837 AA588460 AA490821 BQ711555 AI870400 BC002926 AI660129 AA904938 AA287256 AI474315 AI184147
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for DCAF15 (see all 7) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12a | · | 12b | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DCAF15
|
Expression
for DCAF15 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCAF15 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATAAATGT
About this image
See DCAF15 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCAF15
SOURCE GeneReport for Unigene cluster: Hs.443636
SABiosciences Custom PCR Arrays for DCAF15
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAF15
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCAF15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAF15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAF15 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF15 |
Orthologs
for DCAF15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DCAF15 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Dcaf151 , 5 |
DDB1 and CUL4 associated factor 151, 5 |
86.06(n)1
90.83(a)1 |
|
8 (40.30 cM)5
2121231 NM_172502.31 NP_766090.21
840970725 |
lizard
(Anolis carolinensis) |
Reptilia |
DCAF156 |
-- |
78(a) |
1 ↔ 1 |
2(76943471-76982308) |
African clawed frog
(Xenopus laevis) |
Amphibia |
CD361601.12 |
-- |
77.56(n) |
|
CD361601.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
570457192 |
-- |
72.65(n) |
|
57045719 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG63256 |
-- |
14(a) |
1 ↔ 1 |
3R(6228689-6233007) |
ENSEMBL Gene Tree for DCAF15 (if available)
TreeFam Gene Tree for DCAF15 (if available) |
Paralogs
for DCAF15 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DCAF15 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCAF15 (14063304 - 14072256 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DCAF15
1 Indel: 58861 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAF15 |
|
Disorders
/ Diseases
for DCAF15 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DCAF15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCAF15 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DCAF15) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- An interaction network of the mammalian COP9 signalos ome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for DCAF15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCAF15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCAF15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCAF15 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCAF15 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCAF15 gene:
Search GeneIP for patents involving DCAF15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCAF15 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DCAF15 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCAF15 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAF15 | | | OriGene Protein Over-expression Lysate for DCAF15 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DCAF15 | | OriGene 3'-UTR Clone for DCAF15 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF15 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF15 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCAF15 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAF15 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF15 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCAF15 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAF15 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAF15 |
| |
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| |  |  |  |  | | | | |
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 | | | DCAF15 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF15 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF15 |
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