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Aliases for DCAF13 Gene

Aliases for DCAF13 Gene

  • DDB1 And CUL4 Associated Factor 13 2 3 5
  • WD Repeat And SOF Domain-Containing Protein 1 3 4
  • WD Repeats And SOF1 Domain Containing 2 3
  • WDSOF1 3 4
  • DDB1- And CUL4-Associated Factor 13 3
  • HSPC064 3
  • GM83 3

External Ids for DCAF13 Gene

Previous HGNC Symbols for DCAF13 Gene

  • WDSOF1

Previous GeneCards Identifiers for DCAF13 Gene

  • GC08P104500
  • GC08P099627
  • GC08P104426

Summaries for DCAF13 Gene

GeneCards Summary for DCAF13 Gene

DCAF13 (DDB1 And CUL4 Associated Factor 13) is a Protein Coding gene. Diseases associated with DCAF13 include Parainfluenza Virus Type 3 and Spastic Paraplegia 8, Autosomal Dominant. Among its related pathways are rRNA processing in the nucleus and cytosol and Gene Expression. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for DCAF13 Gene

  • Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF13 Gene

Genomics for DCAF13 Gene

Regulatory Elements for DCAF13 Gene

Enhancers for DCAF13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G103444 1 Ensembl ENCODE 26.7 +30.8 30846 1.9 CTCF MXI1 PKNOX1 JUN SIN3A CEBPG BMI1 ZBTB40 FOSL2 NFE2 DCAF13 SLC25A32 RNU6-1011P ENSG00000266289 ENSG00000261670
GH08G103371 1.5 Ensembl ENCODE dbSUPER 15.5 -42.3 -42254 2.7 PKNOX1 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF48 ZBTB7B ZNF143 FOS DCAF13 BAALC-AS1 FZD6 LINC01181 CTHRC1 SLC25A32 ENSG00000266289
GH08G103413 1.2 ENCODE 15.4 +0.5 483 3.2 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D DCAF13 FZD6 SLC25A32
GH08G102803 1.5 ENCODE dbSUPER 11.5 -607.0 -606952 7.6 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 UBR5 KLF10 FZD6 SLC25A32 DCAF13 ENSG00000272037 LOC401472 AZIN1 ENSG00000253385
GH08G103405 1 Ensembl ENCODE 14.6 -8.1 -8129 1.6 CTCF MXI1 RB1 BACH1 MAX CEBPG RAD21 YY1 GATA3 POLR2A DCAF13 FZD6 CTHRC1 RNU6-1011P LINC01181 SLC25A32 PIR39755
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCAF13 on UCSC Golden Path with GeneCards custom track

Promoters for DCAF13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000228353 486 2801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21

Genomic Location for DCAF13 Gene

Chromosome:
8
Start:
103,414,714 bp from pter
End:
103,443,453 bp from pter
Size:
28,740 bases
Orientation:
Plus strand

Genomic View for DCAF13 Gene

Genes around DCAF13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF13 Gene

Proteins for DCAF13 Gene

  • Protein details for DCAF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV06-DCA13_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 13
    Protein Accession:
    Q9NV06
    Secondary Accessions:
    • Q3MII9
    • Q8NCH8
    • Q8TC51
    • Q96JY7
    • Q9NZX3

    Protein attributes for DCAF13 Gene

    Size:
    445 amino acids
    Molecular mass:
    51402 Da
    Quaternary structure:
    • Interacts with DDB1 (PubMed:16949367). Interacts with ESR1 and LATS1 (PubMed:28068668).
    SequenceCaution:
    • Sequence=AAH26067.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI01811.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI12043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB55377.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11163.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCAF13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF13 Gene

Post-translational modifications for DCAF13 Gene

  • Ubiquitination at Lys49, Lys56, isoforms=304, Lys359, and Lys398
  • Modification sites at PhosphoSitePlus

Other Protein References for DCAF13 Gene

No data available for DME Specific Peptides for DCAF13 Gene

Domains & Families for DCAF13 Gene

Suggested Antigen Peptide Sequences for DCAF13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV06

UniProtKB/Swiss-Prot:

DCA13_HUMAN :
  • Belongs to the WD repeat DCAF13/WDSOF1 family.
Family:
  • Belongs to the WD repeat DCAF13/WDSOF1 family.
genes like me logo Genes that share domains with DCAF13: view

Function for DCAF13 Gene

Molecular function for DCAF13 Gene

UniProtKB/Swiss-Prot Function:
Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0030331 estrogen receptor binding IPI 28068668
genes like me logo Genes that share ontologies with DCAF13: view
genes like me logo Genes that share phenotypes with DCAF13: view

Animal Model Products

CRISPR Products

miRNA for DCAF13 Gene

miRTarBase miRNAs that target DCAF13

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF13 Gene

Localization for DCAF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF13 Gene

Nucleus, nucleolus. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component. {ECO:0000269 PubMed:24754225}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF13 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
mitochondrion 2

Gene Ontology (GO) - Cellular Components for DCAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005813 centrosome IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with DCAF13: view

Pathways & Interactions for DCAF13 Gene

genes like me logo Genes that share pathways with DCAF13: view

UniProtKB/Swiss-Prot Q9NV06-DCA13_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing TAS --
GO:0016567 protein ubiquitination IEA --
GO:0042254 ribosome biogenesis IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DCAF13: view

No data available for SIGNOR curated interactions for DCAF13 Gene

Transcripts for DCAF13 Gene

Unigene Clusters for DCAF13 Gene

DDB1 and CUL4 associated factor 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF13 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1:
SP2:
SP3: -
SP4: -
SP5: - - - - -
SP6:

Relevant External Links for DCAF13 Gene

GeneLoc Exon Structure for
DCAF13
ECgene alternative splicing isoforms for
DCAF13

Expression for DCAF13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF13 Gene

Protein differential expression in normal tissues from HIPED for DCAF13 Gene

This gene is overexpressed in Lung (34.7), Peripheral blood mononuclear cells (7.3), and Pancreatic juice (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCAF13 Gene



Protein tissue co-expression partners for DCAF13 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF13 Gene:

DCAF13

SOURCE GeneReport for Unigene cluster for DCAF13 Gene:

Hs.532265

Evidence on tissue expression from TISSUES for DCAF13 Gene

  • Nervous system(4.6)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with DCAF13: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF13 Gene

Orthologs for DCAF13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF13 34 35
  • 98.65 (n)
dog
(Canis familiaris)
Mammalia DCAF13 34 35
  • 93.03 (n)
cow
(Bos Taurus)
Mammalia DCAF13 34 35
  • 92.08 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 90 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Dcaf13 34 16 35
  • 89.27 (n)
rat
(Rattus norvegicus)
Mammalia Dcaf13 34
  • 89.2 (n)
oppossum
(Monodelphis domestica)
Mammalia DCAF13 35
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF13 34 35
  • 80.23 (n)
lizard
(Anolis carolinensis)
Reptilia DCAF13 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf13 34
  • 73.64 (n)
zebrafish
(Danio rerio)
Actinopterygii dcaf13 34 35
  • 68.51 (n)
-- 34
fruit fly
(Drosophila melanogaster)
Insecta CG7275 34 35
  • 57.47 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010305 34
  • 53.79 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK430.7 34 35
  • 54.26 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOF1 34 35 37
  • 55.58 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15598g 34
  • 54.04 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL157C 34
  • 53.19 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G28450 34
  • 54.34 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4249 34
rice
(Oryza sativa)
Liliopsida Os01g0238900 34
  • 57.2 (n)
Os.1228 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3711 35
  • 63 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1A4.07c 34
  • 52.32 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU01595 34
  • 47.67 (n)
Species where no ortholog for DCAF13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAF13 Gene

ENSEMBL:
Gene Tree for DCAF13 (if available)
TreeFam:
Gene Tree for DCAF13 (if available)

Paralogs for DCAF13 Gene

Pseudogenes.org Pseudogenes for DCAF13 Gene

genes like me logo Genes that share paralogs with DCAF13: view

No data available for Paralogs for DCAF13 Gene

Variants for DCAF13 Gene

Sequence variations from dbSNP and Humsavar for DCAF13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000085552 -- 103,436,177(+) TCTTT(G/T)TCCTG intron-variant
rs1000097637 -- 103,441,955(+) AGAGA(C/G)AGGGT intron-variant
rs1000137960 -- 103,435,902(+) AGAGT(A/G)CACTT intron-variant
rs1000173092 -- 103,440,613(+) CGTAT(C/T)TCTTG intron-variant
rs1000220078 -- 103,418,703(+) ATAAC(A/G)CCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF13 Gene

Variant ID Type Subtype PubMed ID
dgv7279n100 CNV gain 25217958
esv3891453 CNV gain 25118596
nsv1117844 CNV deletion 24896259
nsv1147216 CNV insertion 26484159
nsv611832 CNV loss 21841781

Variation tolerance for DCAF13 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.04; 92.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF13 Gene

Human Gene Mutation Database (HGMD)
DCAF13
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF13 Gene

Disorders for DCAF13 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DCAF13 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
parainfluenza virus type 3
  • human parainfluenza virus type 3
spastic paraplegia 8, autosomal dominant
  • hereditary spastic paraplegia 8
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DCAF13

Genetic Association Database (GAD)
DCAF13
Human Genome Epidemiology (HuGE) Navigator
DCAF13
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF13
genes like me logo Genes that share disorders with DCAF13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DCAF13 Gene

Publications for DCAF13 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 3 4 64
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4 64
  3. The Hippo kinases LATS1 and 2 control human breast cell fate via crosstalk with ERalpha. (PMID: 28068668) Britschgi A. … Bentires-Alj M. (Nature 2017) 3 4 64
  4. Identification of non-synonymous polymorphisms in the WDSOF1 gene as novel susceptibility markers for low bone mineral density in Japanese postmenopausal women. (PMID: 20601284) Urano T. … Inoue S. (Bone 2010) 3 46 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for DCAF13 Gene

Sources for DCAF13 Gene

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