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Aliases for DCAF13 Gene

Aliases for DCAF13 Gene

  • DDB1 And CUL4 Associated Factor 13 2 3
  • WD Repeat And SOF Domain-Containing Protein 1 3 4
  • WD Repeats And SOF1 Domain Containing 2 3
  • WDSOF1 3 4
  • DDB1- And CUL4-Associated Factor 13 3
  • HSPC064 3
  • GM83 3

External Ids for DCAF13 Gene

Previous HGNC Symbols for DCAF13 Gene

  • WDSOF1

Previous GeneCards Identifiers for DCAF13 Gene

  • GC08P104500
  • GC08P099627
  • GC08P104426

Summaries for DCAF13 Gene

GeneCards Summary for DCAF13 Gene

DCAF13 (DDB1 And CUL4 Associated Factor 13) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCAF13 Gene

  • Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF13 Gene

Genomics for DCAF13 Gene

Genomic Location for DCAF13 Gene

Start:
103,414,714 bp from pter
End:
103,443,453 bp from pter
Size:
28,740 bases
Orientation:
Plus strand

Genomic View for DCAF13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF13 Gene

No data available for Regulatory Elements for DCAF13 Gene

Proteins for DCAF13 Gene

  • Protein details for DCAF13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NV06-DCA13_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 13
    Protein Accession:
    Q9NV06
    Secondary Accessions:
    • Q3MII9
    • Q8NCH8
    • Q8TC51
    • Q96JY7
    • Q9NZX3

    Protein attributes for DCAF13 Gene

    Size:
    445 amino acids
    Molecular mass:
    51402 Da
    Quaternary structure:
    • Interacts with DDB1.
    SequenceCaution:
    • Sequence=AAH26067.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI01811.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI12043.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB55377.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11163.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DCAF13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF13 Gene

Proteomics data for DCAF13 Gene at MOPED

Post-translational modifications for DCAF13 Gene

  • Ubiquitination at Lys49, Lys56, Lys304, Lys359, and Lys398
  • Modification sites at PhosphoSitePlus

Other Protein References for DCAF13 Gene

No data available for DME Specific Peptides for DCAF13 Gene

Domains for DCAF13 Gene

Gene Families for DCAF13 Gene

HGNC:
  • DCAF :DDB1 and CUL4 associated factors
  • WDR :WD repeat domain containing

Protein Domains for DCAF13 Gene

Suggested Antigen Peptide Sequences for DCAF13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NV06

UniProtKB/Swiss-Prot:

DCA13_HUMAN :
  • Q9NV06
Family:
  • Belongs to the WD repeat DCAF13/WDSOF1 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF13: view

Function for DCAF13 Gene

Molecular function for DCAF13 Gene

UniProtKB/Swiss-Prot Function: Possible role in ribosomal RNA processing (By similarity). May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DCAF13: view
genes like me logo Genes that share phenotypes with DCAF13: view

miRNA for DCAF13 Gene

miRTarBase miRNAs that target DCAF13

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF13 Gene

Localization for DCAF13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF13 Gene

Nucleus, nucleolus. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component. {ECO:0000269 PubMed:24754225}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF13 Gene COMPARTMENTS Subcellular localization image for DCAF13 gene
Compartment Confidence
mitochondrion 2
nucleus 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DCAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005730 nucleolus IBA --
GO:0030529 ribonucleoprotein complex --
GO:0032040 small-subunit processome IBA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF13: view

Pathways for DCAF13 Gene

SuperPathways for DCAF13 Gene

No Data Available

UniProtKB/Swiss-Prot Q9NV06-DCA13_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA --
GO:0006364 rRNA processing --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF13: view

No data available for Pathways by source for DCAF13 Gene

Transcripts for DCAF13 Gene

Unigene Clusters for DCAF13 Gene

DDB1 and CUL4 associated factor 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF13 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11
SP1:
SP2:
SP3: -
SP4: -
SP5: - - - - -
SP6:

Relevant External Links for DCAF13 Gene

GeneLoc Exon Structure for
DCAF13
ECgene alternative splicing isoforms for
DCAF13

Expression for DCAF13 Gene

mRNA expression in normal human tissues for DCAF13 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF13 Gene

SOURCE GeneReport for Unigene cluster for DCAF13 Gene Hs.532265

genes like me logo Genes that share expressions with DCAF13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAF13 Gene

Orthologs for DCAF13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF13 35
  • 98.65 (n)
  • 97.33 (a)
DCAF13 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCAF13 35
  • 92.08 (n)
  • 95.02 (a)
DCAF13 36
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF13 35
  • 93.03 (n)
  • 96.85 (a)
DCAF13 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf13 35
  • 89.27 (n)
  • 93.1 (a)
Dcaf13 16
Dcaf13 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAF13 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 79 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dcaf13 35
  • 89.2 (n)
  • 92.64 (a)
chicken
(Gallus gallus)
Aves DCAF13 35
  • 80.23 (n)
  • 88.74 (a)
DCAF13 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF13 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf13 35
  • 73.64 (n)
  • 80 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
dcaf13 35
  • 68.51 (n)
  • 74.25 (a)
dcaf13 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010305 35
  • 53.79 (n)
  • 52.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7275 35
  • 57.47 (n)
  • 58.62 (a)
CG7275 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ZK430.7 35
  • 54.26 (n)
  • 49.88 (a)
ZK430.7 36
  • 47 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL157C 35
  • 53.19 (n)
  • 48.96 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SOF1 35
  • 55.58 (n)
  • 48.27 (a)
SOF1 36
  • 44 (a)
OneToOne
SOF1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F15598g 35
  • 54.04 (n)
  • 46.19 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.4249 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G28450 35
  • 54.34 (n)
  • 48.37 (a)
rice
(Oryza sativa)
Liliopsida Os.1228 35
Os01g0238900 35
  • 57.2 (n)
  • 55.11 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01595 35
  • 47.67 (n)
  • 44.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1A4.07c 35
  • 52.32 (n)
  • 47.52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3711 36
  • 63 (a)
OneToOne
Species with no ortholog for DCAF13:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAF13 Gene

ENSEMBL:
Gene Tree for DCAF13 (if available)
TreeFam:
Gene Tree for DCAF13 (if available)

Paralogs for DCAF13 Gene

Pseudogenes.org Pseudogenes for DCAF13 Gene

genes like me logo Genes that share paralogs with DCAF13: view

No data available for Paralogs for DCAF13 Gene

Variants for DCAF13 Gene

Sequence variations from dbSNP and Humsavar for DCAF13 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1954 -- 103,441,608(-) TCGAC(A/G)AGCTT reference, missense
rs751725 -- 103,436,854(+) AAATT(A/G)TGATA intron-variant
rs893044 -- 103,436,870(+) ATGAT(C/T)ATGGT intron-variant
rs975440 -- 103,435,425(+) TTGGT(A/G)TATAT intron-variant
rs1370005 -- 103,432,781(-) CATTC(A/C)TGATA intron-variant

Relevant External Links for DCAF13 Gene

HapMap Linkage Disequilibrium report
DCAF13
Human Gene Mutation Database (HGMD)
DCAF13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DCAF13 Gene

Disorders for DCAF13 Gene

Relevant External Links for DCAF13

Genetic Association Database (GAD)
DCAF13
Human Genome Epidemiology (HuGE) Navigator
DCAF13
genes like me logo Genes that share disorders with DCAF13: view

No data available for UniProtKB/Swiss-Prot for DCAF13 Gene

Publications for DCAF13 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4
  4. Identification of non-synonymous polymorphisms in the WDSOF1 gene as novel susceptibility markers for low bone mineral density in Japanese postmenopausal women. (PMID: 20601284) Urano T. … Inoue S. (Bone 2010) 3 48
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for DCAF13 Gene

Sources for DCAF13 Gene

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