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Aliases for DCAF12L2 Gene

Aliases for DCAF12L2 Gene

  • DDB1 And CUL4 Associated Factor 12-Like 2 2 3
  • WD Repeat-Containing Protein 40C 3 4
  • WDR40C 3 4
  • WD Repeat Domain 40C 2

External Ids for DCAF12L2 Gene

Previous HGNC Symbols for DCAF12L2 Gene

  • WDR40C

Previous GeneCards Identifiers for DCAF12L2 Gene

  • GC0XM125127
  • GC0XM125298
  • GC0XM114677

Summaries for DCAF12L2 Gene

Entrez Gene Summary for DCAF12L2 Gene

  • This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 9. However, the CDS of this intronless gene remains intact, it is conserved in other mammalian species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]

GeneCards Summary for DCAF12L2 Gene

DCAF12L2 (DDB1 And CUL4 Associated Factor 12-Like 2) is a Protein Coding gene. An important paralog of this gene is DCAF12L1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF12L2 Gene

Genomics for DCAF12L2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAF12L2 Gene

126,163,499 bp from pter
126,166,097 bp from pter
2,599 bases
Minus strand

Genomic View for DCAF12L2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for DCAF12L2 Gene

No data available for Regulatory Elements for DCAF12L2 Gene

Proteins for DCAF12L2 Gene

  • Protein details for DCAF12L2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 12-like protein 2
    Protein Accession:
    Secondary Accessions:
    • B2RN42

    Protein attributes for DCAF12L2 Gene

    463 amino acids
    Molecular mass:
    50803 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DCAF12L2 Gene

Proteomics data for DCAF12L2 Gene at MOPED

Post-translational modifications for DCAF12L2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF12L2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DCAF12L2

No data available for DME Specific Peptides for DCAF12L2 Gene

Domains & Families for DCAF12L2 Gene

Gene Families for DCAF12L2 Gene

Protein Domains for DCAF12L2 Gene

Suggested Antigen Peptide Sequences for DCAF12L2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat DCAF12 family.
  • Contains 7 WD repeats.
  • Belongs to the WD repeat DCAF12 family.
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF12L2: view

Function for DCAF12L2 Gene

Gene Ontology (GO) - Molecular Function for DCAF12L2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF12L2: view

Phenotypes for DCAF12L2 Gene

GenomeRNAi human phenotypes for DCAF12L2:
genes like me logo Genes that share phenotypes with DCAF12L2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF12L2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF12L2 Gene

Localization for DCAF12L2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for DCAF12L2 Gene

Pathways & Interactions for DCAF12L2 Gene

SuperPathways for DCAF12L2 Gene

No Data Available

Interacting Proteins for DCAF12L2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000353128 for DCAF12L2 Gene via STRING

Gene Ontology (GO) - Biological Process for DCAF12L2 Gene


No data available for Pathways by source and SIGNOR curated interactions for DCAF12L2 Gene

Drugs & Compounds for DCAF12L2 Gene

No Compound Related Data Available

Transcripts for DCAF12L2 Gene

mRNA/cDNA for DCAF12L2 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DCAF12L2 Gene

DDB1 and CUL4 associated factor 12-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF12L2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF12L2 Gene

No ASD Table

Relevant External Links for DCAF12L2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF12L2 Gene

mRNA expression in normal human tissues for DCAF12L2 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF12L2 Gene

This gene is overexpressed in Testis (x6.8) and Brain - Hypothalamus (x5.3).

SOURCE GeneReport for Unigene cluster for DCAF12L2 Gene Hs.181867

genes like me logo Genes that share expression patterns with DCAF12L2: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DCAF12L2 Gene

Orthologs for DCAF12L2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF12L2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LOC100847467 35
  • 81.19 (n)
  • 75.41 (a)
(Canis familiaris)
Mammalia LOC492114 35
  • 88.31 (n)
  • 88.53 (a)
-- 36
  • 85 (a)
-- 36
  • 81 (a)
(Mus musculus)
Mammalia Dcaf12l2 35
  • 80.06 (n)
  • 83.15 (a)
Dcaf12l2 16
Dcaf12l1 36
  • 71 (a)
Dcaf12l2 36
  • 81 (a)
(Pan troglodytes)
Mammalia LOC100613674 35
  • 99.42 (n)
  • 99.57 (a)
DCAF12L2 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Dcaf12l2 35
  • 79.99 (n)
  • 82.94 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3313 36
  • 38 (a)
Species with no ortholog for DCAF12L2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DCAF12L2 Gene

Gene Tree for DCAF12L2 (if available)
Gene Tree for DCAF12L2 (if available)

Paralogs for DCAF12L2 Gene

Paralogs for DCAF12L2 Gene

(2) SIMAP similar genes for DCAF12L2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCAF12L2: view

Variants for DCAF12L2 Gene

Sequence variations from dbSNP and Humsavar for DCAF12L2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3761552 -- 126,164,707(+) CTGCC(A/G)CAGGC reference, synonymous-codon
rs5977933 -- 126,164,500(+) AGGTA(A/C)ACCTG utr-variant-3-prime
rs5977934 -- 126,166,389(+) CGCGC(A/G)GGGTG upstream-variant-2KB
rs6638149 -- 126,166,399(+) GGAGG(C/T)TGGAA upstream-variant-2KB
rs7880872 -- 126,166,153(+) GCGGT(C/G)GTCCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DCAF12L2 Gene

Variant ID Type Subtype PubMed ID
nsv524503 CNV Gain 19592680
nsv519795 CNV Gain 19592680

Variation tolerance for DCAF12L2 Gene

Residual Variation Intolerance Score: 45.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF12L2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF12L2 Gene

Disorders for DCAF12L2 Gene

Relevant External Links for DCAF12L2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DCAF12L2: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF12L2 Gene

Publications for DCAF12L2 Gene

  1. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67
  2. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 67
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for DCAF12L2 Gene

Sources for DCAF12L2 Gene

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