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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DCAF12 Gene

protein-coding GIFtS: 45
GCID: GC09M034079

DDB1 and CUL4 associated factor 12

(Previous names: KIAA1892, WD repeat domain 40A )
(Previous symbols: KIAA1892, WDR40A)

Explore 1 disease affiliated with
DCAF12 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
DDB1 And CUL4 Associated Factor 12¹ ²		Testis Cancer Centrosome-Related Protein² ³
KIAA1892¹ ² ³		WD Repeat-Containing Protein 40A² ³
TCC52¹ ² ³		DKFZP434O125¹
WDR40A¹ ² ³		MGC1058¹
CT102¹ ²		Cancer/Testis Antigen 102²
WD Repeat Domain 40A¹ ²		DDB1- And CUL4-Associated Factor 12²
Centrosome-Related Protein TCC52² ³

External Ids:	HGNC: 19911¹	Entrez Gene: 25853²	Ensembl: ENSG00000198876⁷	UniProtKB: Q5T6F0³

Export aliases for DCAF12 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DCAF12:

This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex

that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates.

(provided by RefSeq, Jul 2009)

UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0

Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NC_018920.1 NT_008413.18

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for DCAF12
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DCAF12 promoter sequence

Search SABiosciences Chromatin IP Primers for DCAF12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF12

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3 Ensembl cytogenetic band: 9p13.3 HGNC cytogenetic band: 9p11.2

DCAF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF12 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M034079: view genomic region (about GC identifiers)

Start:	34,086,381 bp from pter	End:	34,127,397 bp from pter
Size:	41,017 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0 (See protein sequence)

Recommended Name: DDB1- and CUL4-associated factor 12

Size: 453 amino acids; 50517 Da

Subunit: Interacts with DDB1

Subcellular location: Cytoplasm. Cytoplasm, cytoskeleton, centrosome

Sequence caution: Sequence=BAA91106.1; Type=Frameshift; Positions=27; Sequence=BAB67785.1; Type=Erroneous initiation;

Sequence=CAI15300.1; Type=Erroneous gene model prediction; Sequence=CAI15302.1; Type=Erroneous gene model prediction;

1 PDB 3D structure from and Proteopedia for DCAF12:

3I7P (3D)

Secondary accessions: A8KA70 D3DRL6 Q5T6E9 Q5T6F1 Q6P3V0 Q7L4F8 Q96PZ5 Q9NXA9 Q9UFJ1

Explore the universe of human proteins at neXtProt for DCAF12: NX_Q5T6F0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5T6F0

DCAF12 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_056212.1

ENSEMBL proteins:

ENSP00000355114 ENSP00000380187 ENSP00000415833

Human Recombinant Protein Products for DCAF12:

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	Uscn Proteins for DCAF12

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18957058
GO:0005813	centrosome	IDA	18957058
GO:0080008	Cul4-RING ubiquitin ligase complex	IDA	16949367

DCAF12 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DCAF12 for domains About GeneDecksing

4 InterPro domains/families:

IPR019775 WD40_repeat_CS

IPR001680 WD40_repeat

IPR017986 WD40_repeat_dom

IPR015943 WD40/YVTN_repeat-like_dom

Graphical View of Domain Structure for InterPro Entry Q5T6F0

ProtoNet protein and cluster: Q5T6F0

UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0

Similarity: Belongs to the WD repeat DCAF12 family

Similarity: Contains 4 WD repeats

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DCA12_HUMAN, Q5T6F0

Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DCAF12

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		hsa-miR-520e hsa-miR-3938 hsa-miR-300 hsa-miR-146a hsa-miR-138-2* hsa-miR-371-5p hsa-miR-208b hsa-miR-508-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DCAF12 3' UTR sequence

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0

Pathway: Protein modification; protein ubiquitination

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DCAF12

STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

5/27 Interacting proteins for DCAF12 (Q5T6F0³ ENSP00000355114⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 27)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDB1	Q16531³, ENSP00000301764⁴	I2D: score=1 STRING: ENSP00000301764
CUL4A	Q13619³, ENSP00000364589⁴	I2D: score=1 STRING: ENSP00000364589
BMPR1B	O00238³, ENSP00000264568⁴	I2D: score=3 STRING: ENSP00000264568
TGFBR1	P36897³, ENSP00000364133⁴	I2D: score=4 STRING: ENSP00000364133
AXIN2	Q9Y2T1³	I2D: score=1

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016567	protein ubiquitination	IEA	--

DCAF12 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DCAF12
Search CenterWatch for drugs/clinical trials and news about DCAF12 / DCA12

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DCAF12 gene:

NM_015397.3

Unigene Clusters for DCAF12:

DDB1 and CUL4 associated factor 12

Hs.493750 [show with all ESTs], Hs.741270 [show with all ESTs]

Unigene Representative Sequences: BM477163, NM_015397

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000361264(uc003ztt.2) ENST00000466402 ENST00000396990 ENST00000450964

ENST00000463286

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		hsa-miR-520e hsa-miR-3938 hsa-miR-300 hsa-miR-146a hsa-miR-138-2* hsa-miR-371-5p hsa-miR-208b hsa-miR-508-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DCAF12 3' UTR sequence

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Additional cDNA sequence:

AB067479.1 AF131771.1 AK000354.1 AK292935.1 AL117646.1 BC008893.2 BC063823.1 DQ518909.1

10 DOTS entries:

DT.456182 DT.100757767 DT.100708325 DT.92057874 DT.121203710 DT.91719845 DT.100815044 DT.440635

DT.95356002 DT.97774544

24/322 AceView cDNA sequences (see all 322):

AA835632 BQ425196 BQ424510 AI680758 BP374864 CD366727 AL039439 AI247498

BM772534 BU621649 AI431598 AW300712 AW673670 AA740245 BM978464 CR591883

AA383244 CR622703 AA233436 AI620401 AI074601 BU626038 AA418508 BI966162

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DCAF12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCAAAGATAA

About this image
See DCAF12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCAF12

SOURCE GeneReport for Unigene clusters: Hs.493750 Hs.741270

UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0

Tissue specificity: Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal

testis

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DCAF12 gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dcaf12^{1 , 5}	DDB1 and CUL4 associated factor 12^{1, 5}	91.61(n)¹ 98.45(a)¹		4 (21.32 cM)⁵ 68970¹ NM_026893.3¹ NP_081169.2¹ 41291300⁵
chicken (Gallus gallus)	Aves	DCAF12¹	DDB1 and CUL4 associated factor 12	80.5(n) 91.27(a)		427396 NM_001031444.1 NP_001026615.1
lizard (Anolis carolinensis)	Reptilia	DCAF12⁶	--	92(a)	1 ↔ 1	GL343372.1(914101-924597)
African clawed frog (Xenopus laevis)	Amphibia	Xl.3728²	Xenopus laevis transcribed sequence with moderate similarity to protein pirT17338 (H.sapiens) T17338 hypothetical protein DKFZp434O125.1 - human (fragment) less	79.27(n)		CF286017.1
zebrafish (Danio rerio)	Actinopterygii	dcaf12¹	DDB1 and CUL4 associated factor 12	68.83(n) 77.35(a)		570671 NM_001077580.1 NP_001071048.1
fruit fly (Drosophila melanogaster)	Insecta	CG3313¹	CG3313	50.96(n) 43.3(a)		41460 NM_141888.3 NP_650145.1

ENSEMBL Gene Tree for DCAF12 (if available)
TreeFam Gene Tree for DCAF12 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DCAF12 gene

DCAF12L1² DCAF12L2²

2 SIMAP similar genes for DCAF12 using alignment to 1 protein entry: DCA12_HUMAN:

DCAF12L2 DCAF12L1

DCAF12 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs73491038^1,2	C	--	34086024(+)	`AATATC/TCTATT`	1	--	ds500¹		2		WA	120
rs186099979^1,2		--	34086160(+)	`TCCACC/TCTCAG`	1	--	ds500¹		0	--	--	--	--
rs191099220^1,2		--	34086490(+)	`AAGAGC/GGTCTA`	1	--	ut3¹		0	--	--	--	--
rs182117524^1,2		--	34086577(+)	`AGAACA/TAAGAA`	1	--	ut3¹		0	--	--	--	--
rs117317727^1,2	F	--	34086760(+)	`CTCTCC/TTCTCC`	1	--	ut3¹		1		EA	120
rs76839219^1,2	C	--	34086795(+)	`GAATAC/TATATA`	1	--	ut3¹		0	--	--	--	--
rs148638383^1,2		--	34086798(+)	`TATATA/GTATAA`	1	--	ut3¹		0	--	--	--	--
rs74458889^1,2	F	--	34086859(+)	`GAGAAC/GAAGTT`	1	--	ut3¹		1		EA	120
rs187779151^1,2		--	34086975(+)	`TGTTAC/TCTTTG`	1	--	ut3¹		0	--	--	--	--
rs143120526^1,2		--	34087182(+)	`GTGGCG/TTCAAC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DCAF12 (34086381 - 34127397 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for DCAF12
1 CNV: 36949
1 Indel: 59526

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAF12

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DCAF12 for disorders About GeneDecksing

1 disease for DCAF12: About MalaCards

lung cancer

Export disorders for DCAF12 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DCAF12 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with DCAF12)

Utopia: connect your pdf to the dynamic
world of online information

Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)^{1, 2, 3} Nagase T....Ohara O. (2001)
Novel centrosome protein, TCC52, is a cancer-testis antigen. (PubMed id 18957058)^{1, 2} Li S....He D. (2008)
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)^{1, 2} Jin J.... Walter J.C. (2006)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)^{1, 3} Yu W.... Gibbs R.A. (1997)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)
Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)¹ Bennett E.J....Harper J.W. (2010)
An interaction network of the mammalian COP9 signalos ome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)¹ Olma M.H....Pintard L. (2009)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 25853	HGNC: 19911	AceView: WDR40A	Ensembl:ENSG00000198876	euGenes: HUgn25853
ECgene: DCAF12	H-InvDB: DCAF12

(According to HUGE)
About This Section

HUGE: KIAA1892

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DCAF12	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DCAF12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DCAF12 gene:
Search GeneIP for patents involving DCAF12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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DDB1 and CUL4 associated factor 12

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DDB1 and CUL4 associated factor 12

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