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DCAF12 Gene

protein-coding   GIFtS: 47
GCID: GC09M034079

DDB1 And CUL4 Associated Factor 12

(Previous names: KIAA1892, WD repeat domain 40A)
(Previous symbols: KIAA1892, WDR40A)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DDB1 And CUL4 Associated Factor 121 2     Testis Cancer Centrosome-Related Protein2 3
KIAA18921 2 3     TCC522 3
WDR40A1 2 3     WD Repeat-Containing Protein 40A2 3
WD Repeat Domain 40A1 2     CT1022
Cancer/Testis Antigen 1021 2     DDB1- And CUL4-Associated Factor 122
Centrosome-Related Protein TCC522 3     

External Ids:    HGNC: 199111   Entrez Gene: 258532   Ensembl: ENSG000001988767   UniProtKB: Q5T6F03   

Export aliases for DCAF12 gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCAF12 Gene:
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular
complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8
conjugates. (provided by RefSeq, Jul 2009)

GeneCards Summary for DCAF12 Gene:
DCAF12 (DDB1 and CUL4 associated factor 12) is a protein-coding gene. An important paralog of this gene is DCAF12L1.

UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0
Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NT_008413.19  NC_018920.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DCAF12
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCAF12 promoter sequence
   Search Chromatin IP Primers for DCAF12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCAF12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.3   Ensembl cytogenetic band:  9p13.3   HGNC cytogenetic band: 9p11.2

DCAF12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF12 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M034079:  view genomic region     (about GC identifiers)

Start:
34,086,381 bp from pter      End:
34,127,397 bp from pter
Size:
41,017 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0 (See protein sequence)
Recommended Name: DDB1- and CUL4-associated factor 12  
Size: 453 amino acids; 50517 Da
Subunit: Interacts with DDB1
Sequence caution: Sequence=BAA91106.1; Type=Frameshift; Positions=27; Sequence=BAB67785.1; Type=Erroneous
initiation; Sequence=CAI15300.1; Type=Erroneous gene model prediction; Sequence=CAI15302.1; Type=Erroneous gene
model prediction;
1 PDB 3D structure from and Proteopedia for DCAF12:
3I7P (3D)    
Secondary accessions: A8KA70 D3DRL6 Q5T6E9 Q5T6F1 Q6P3V0 Q7L4F8 Q96PZ5 Q9NXA9 Q9UFJ1

Explore the universe of human proteins at neXtProt for DCAF12: NX_Q5T6F0

Explore proteomics data for DCAF12 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DCAF12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056212.1  
    ENSEMBL proteins: 
     ENSP00000355114   ENSP00000380187   ENSP00000415833  

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    antibodies-online proteins for DCAF12 (2 products) 

     
    antibodies-online peptides for DCAF12

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5T6F0

    ProtoNet protein and cluster: Q5T6F0

    UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0
    Similarity: Belongs to the WD repeat DCAF12 family
    Similarity: Contains 4 WD repeats


    Find genes that share domains with DCAF12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCA12_HUMAN, Q5T6F0
    Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with DCAF12           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DCAF12

    miRNA
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    miRTarBase miRNAs that target DCAF12:
    hsa-mir-29c-3p (MIRT020403), hsa-mir-7-5p (MIRT025714), hsa-mir-128-3p (MIRT021915), hsa-mir-92a-3p (MIRT048996), hsa-mir-30b-5p (MIRT023421), hsa-mir-615-3p (MIRT039612)

    Block miRNA regulation of human, mouse, rat DCAF12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF12 (see all 78):
    hsa-miR-520e hsa-miR-3938 hsa-miR-300 hsa-miR-146a hsa-miR-138-2* hsa-miR-371-5p hsa-miR-208b hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidDCAF12 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat DCAF12

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DCA12_HUMAN, Q5T6F0: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18957058
    GO:0005813centrosome IDA18957058
    GO:0080008Cul4-RING ubiquitin ligase complex IDA16949367

    Find genes that share ontologies with DCAF12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCAF12
    Interactions:

        Search GeneGlobe Interaction Network for DCAF12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCAF12 (Q5T6F03 ENSP000003551144) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    CUL4AQ136193, ENSP000003645894I2D: score=1 STRING: ENSP00000364589
    BMPR1BO002383, ENSP000002645684I2D: score=3 STRING: ENSP00000264568
    TGFBR1P368973, ENSP000003641334I2D: score=4 STRING: ENSP00000364133
    AXIN2Q9Y2T13I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    Find genes that share ontologies with DCAF12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCAF12 (DCA12)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DCAF12 gene: 
    NM_015397.3  

    Unigene Cluster for DCAF12:

    DDB1 and CUL4 associated factor 12
    Hs.493750  [show with all ESTs]
    Unigene Representative Sequence: BM477163
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361264(uc003ztt.2) ENST00000466402 ENST00000396990 ENST00000450964
    ENST00000463286
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DCAF12 (see all 78):
    hsa-miR-520e hsa-miR-3938 hsa-miR-300 hsa-miR-146a hsa-miR-138-2* hsa-miR-371-5p hsa-miR-208b hsa-miR-508-5p
    SwitchGear 3'UTR luciferase reporter plasmidDCAF12 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat DCAF12

    Additional mRNA sequence: BC127177.1 

    4 DOTS entries:

    DT.456182  DT.100708325  DT.121203710  DT.100757767 

    Selected AceView cDNA sequences (see all 322):

    BU158633 CD366727 BU625360 AA835632 AW594242 AA383244 T89856 AA676565 
    BI965998 BM750613 BM978464 AA740245 BI834589 BI966162 CF528666 AA832256 
    BQ425196 BQ423694 AI680758 CA447119 AW731634 BU626038 AA676535 AA745488 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCAF12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCAAAGATAA
    DCAF12 Expression
    About this image

    DCAF12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCAF12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.493750

    UniProtKB/Swiss-Prot: DCA12_HUMAN, Q5T6F0
    Tissue specificity: Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in
    normal testis

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DCAF12 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcaf121 , 5 DDB1 and CUL4 associated factor 121, 5 91.61(n)1
    98.45(a)1
      4 (21.32 cM)5
    689701  NM_026893.31  NP_081169.21 
     412913005 
    chicken
    (Gallus gallus)
    Aves DCAF121 DDB1 and CUL4 associated factor 12 80.5(n)
    91.27(a)
      427396  NM_001031444.1  NP_001026615.1 
    lizard
    (Anolis carolinensis)
    Reptilia DCAF126
    DDB1 and CUL4 associated factor 12
    92(a)
    1 ↔ 1
    GL343372.1(914088-924597)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.37282 Xenopus laevis transcribed sequence with moderate similarity to protein pirT17338 (H.sapiens) T17338 hypothetical protein DKFZp434O125.1 - human (fragment) less 79.27(n)    CF286017.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dcaf121 DDB1 and CUL4 associated factor 12 68.83(n)
    77.35(a)
      570671  NM_001077580.1  NP_001071048.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG33131 CG3313 51.2(n)
    43.75(a)
      41460  NM_001275566.1  NP_001262495.1 


    ENSEMBL Gene Tree for DCAF12 (if available)
    TreeFam Gene Tree for DCAF12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DCAF12 gene
    DCAF12L12  DCAF12L22  
    2 SIMAP similar genes for DCAF12 using alignment to 1 protein entry:     DCA12_HUMAN:
    DCAF12L2    DCAF12L1

    Find genes that share paralogs with DCAF12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCAF12 (see all 896)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358520351,2
    C--34060266(+) AAAAA-/A/A   
       AAAAA
    GAGAA
    1 -- int11NA 2
    rs734910381,2
    C,F--34086024(+) AATATC/TCTATT 1 -- ds50012Minor allele frequency- T:0.10WA 120
    rs1860999791,2
    --34086160(+) TCCACC/TCTCAG 1 -- ds50010--------
    rs1910992201,2
    --34086490(+) AAGAGC/GGTCTA 1 -- ut310--------
    rs1821175241,2
    --34086577(+) AGAACA/TAAGAA 1 -- ut310--------
    rs1173177271,2
    C,F--34086760(+) CTCTCC/TTCTCC 1 -- ut311Minor allele frequency- T:0.02EA 120
    rs768392191,2
    C--34086795(+) GAATAC/TATATA 1 -- ut310--------
    rs1486383831,2
    --34086798(+) TATATA/GTATAA 1 -- ut310--------
    rs744588891,2
    C,F--34086859(+) GAGAAC/GAAGTT 1 -- ut311Minor allele frequency- G:0.05EA 120
    rs1877791511,2
    --34086975(+) TGTTAC/TCTTTG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DCAF12 (34086381 - 34127397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for DCAF12:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1336e199CNV Deletion23128226
    esv2676427CNV Deletion23128226
    nsv509300CNV Insertion20534489
    esv1229280CNV Insertion17803354
    nsv6525CNV Loss18451855
    nsv893030CNV Gain21882294
    nsv893033CNV Gain21882294
    nsv520467CNV Gain19592680
    nsv893028CNV Gain21882294
    nsv819806CNV Gain19587683

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCAF12 gene, integrated from 10 sources (see all 23):
    (articles sorted by number of sources associating them with DCAF12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PubMed id 11572484)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2001)
    2. Novel centrosome protein, TCC52, is a cancer-testis antigen. (PubMed id 18957058)1, 2 Li S.... He D. (Cancer Sci. 2008)
    3. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (Mol. Cell 2006)
    4. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PubMed id 16964240)1, 2 Angers S.... Zheng N. (Nature 2006)
    5. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (Genome Res. 1997)
    6. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    10. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (Cell 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
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    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25853 HGNC: 19911 AceView: WDR40A Ensembl:ENSG00000198876 euGenes: HUgn25853
    ECgene: DCAF12 H-InvDB: DCAF12

    (According to HUGE)
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    HUGE: KIAA1892

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DCAF12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCAF12 gene:
    Search GeneIP for patents involving DCAF12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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