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Aliases for DCAF12 Gene

Aliases for DCAF12 Gene

  • DDB1 And CUL4 Associated Factor 12 2 3 5
  • KIAA1892 2 3 4
  • Testis Cancer Centrosome-Related Protein 3 4
  • Centrosome-Related Protein TCC52 3 4
  • WD Repeat-Containing Protein 40A 3 4
  • Cancer/Testis Antigen 102 2 3
  • WD Repeat Domain 40A 2 3
  • WDR40A 3 4
  • TCC52 3 4
  • DDB1- And CUL4-Associated Factor 12 3
  • CT102 3

External Ids for DCAF12 Gene

Previous HGNC Symbols for DCAF12 Gene

  • KIAA1892
  • WDR40A

Summaries for DCAF12 Gene

Entrez Gene Summary for DCAF12 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF12 Gene

DCAF12 (DDB1 And CUL4 Associated Factor 12) is a Protein Coding gene. An important paralog of this gene is DCAF12L2.

UniProtKB/Swiss-Prot for DCAF12 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF12 Gene

Genomics for DCAF12 Gene

Regulatory Elements for DCAF12 Gene

Enhancers for DCAF12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G034157 1.3 Ensembl ENCODE 13.3 -31.3 -31329 1.6 ATF1 FOXA2 PKNOX1 ZNF2 ZNF48 ZNF121 ZNF766 FOS SP3 SP5 IMPDH1P1 DCAF12 ENSG00000228352 UBAP1 GC09P034251 PIR62533
GH09G034185 1.2 Ensembl ENCODE 12 -59.1 -59140 2.6 FEZF1 BRCA1 ZNF2 YY1 ZNF121 GATA2 FOS SP3 JUNB TSHZ1 NUDT2 UBAP1 IMPDH1P1 DCAF12 RPL35AP2 LOC114224
GH09G034071 1.2 Ensembl ENCODE 11.1 +54.3 54306 3.0 HNRNPUL1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 ZNF121 ZNF143 FOS UBAP2 RNU4ATAC11P DCAF12 IMPDH1P1 SNORD121A ENSG00000260947 UBE2R2 ENSG00000228352 RN7SKP114
GH09G034191 1.1 Ensembl ENCODE 12 -64.3 -64331 1.2 TBP FOXA2 ARID4B FEZF1 RAD21 YY1 ZNF335 CREM THAP11 ZHX2 IMPDH1P1 DCAF12 ENSG00000228352 KIF24 GC09P034248 GC09M034194
GH09G034341 1.2 Ensembl ENCODE dbSUPER 10 -216.4 -216428 5.0 NFIA CEBPG ZIC2 NR2F2 YY1 OSR2 JUND ATF3 HNF4A SMAD4 NUDT2 KIAA1161 C9orf24 RNU2-50P FAM219A DNAI1 IMPDH1P1 DCAF12 ENSG00000230729 RPP25L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCAF12 on UCSC Golden Path with GeneCards custom track

Promoters for DCAF12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for DCAF12 Gene

34,086,383 bp from pter
34,127,399 bp from pter
41,017 bases
Minus strand

Genomic View for DCAF12 Gene

Genes around DCAF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF12 Gene

Proteins for DCAF12 Gene

  • Protein details for DCAF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    DDB1- and CUL4-associated factor 12
    Protein Accession:
    Secondary Accessions:
    • A8KA70
    • D3DRL6
    • Q5T6E9
    • Q5T6F1
    • Q6P3V0
    • Q7L4F8
    • Q96PZ5
    • Q9NXA9
    • Q9UFJ1

    Protein attributes for DCAF12 Gene

    453 amino acids
    Molecular mass:
    50517 Da
    Quaternary structure:
    • Interacts with DDB1.
    • Sequence=BAA91106.1; Type=Frameshift; Positions=27; Evidence={ECO:0000305}; Sequence=BAB67785.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15300.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCAF12 Gene

neXtProt entry for DCAF12 Gene

Post-translational modifications for DCAF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF12 Gene

No data available for DME Specific Peptides for DCAF12 Gene

Domains & Families for DCAF12 Gene

Protein Domains for DCAF12 Gene

Suggested Antigen Peptide Sequences for DCAF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat DCAF12 family.
  • Belongs to the WD repeat DCAF12 family.
genes like me logo Genes that share domains with DCAF12: view

Function for DCAF12 Gene

Molecular function for DCAF12 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
genes like me logo Genes that share phenotypes with DCAF12: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF12 Gene

Localization for DCAF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF12 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF12 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for DCAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18957058
GO:0005813 centrosome IDA 18957058
GO:0005815 microtubule organizing center IEA --
GO:0005856 cytoskeleton IEA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF12: view

Pathways & Interactions for DCAF12 Gene

SuperPathways for DCAF12 Gene

No Data Available

UniProtKB/Swiss-Prot Q5T6F0-DCA12_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF12: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF12 Gene

Drugs & Compounds for DCAF12 Gene

No Compound Related Data Available

Transcripts for DCAF12 Gene

Unigene Clusters for DCAF12 Gene

DDB1 and CUL4 associated factor 12:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF12 Gene

No ASD Table

Relevant External Links for DCAF12 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DCAF12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF12 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF12 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for DCAF12 Gene

This gene is overexpressed in Synovial fluid (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCAF12 Gene

Protein tissue co-expression partners for DCAF12 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF12 Gene:


SOURCE GeneReport for Unigene cluster for DCAF12 Gene:


mRNA Expression by UniProt/SwissProt for DCAF12 Gene:

Tissue specificity: Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis.

Evidence on tissue expression from TISSUES for DCAF12 Gene

  • Nervous system(4.9)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with DCAF12: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF12 Gene

Orthologs for DCAF12 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF12 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DCAF12 34 35
  • 99.77 (n)
(Canis familiaris)
Mammalia DCAF12 34 35
  • 94.19 (n)
(Bos Taurus)
Mammalia DCAF12 34 35
  • 93.89 (n)
(Mus musculus)
Mammalia Dcaf12 34 16 35
  • 91.61 (n)
(Monodelphis domestica)
Mammalia DCAF12 35
  • 89 (a)
(Rattus norvegicus)
Mammalia LOC682812 34
  • 83.22 (n)
(Ornithorhynchus anatinus)
Mammalia DCAF12 35
  • 74 (a)
(Gallus gallus)
Aves DCAF12 34 35
  • 80.5 (n)
(Anolis carolinensis)
Reptilia DCAF12 35
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf12 34
  • 73.69 (n)
MGC76023 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3728 34
(Danio rerio)
Actinopterygii dcaf12 34 35
  • 68.83 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002260 34
  • 51.74 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3313 34 35
  • 51.2 (n)
Species where no ortholog for DCAF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF12 Gene

Gene Tree for DCAF12 (if available)
Gene Tree for DCAF12 (if available)

Paralogs for DCAF12 Gene

Paralogs for DCAF12 Gene

(2) SIMAP similar genes for DCAF12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCAF12: view

Variants for DCAF12 Gene

Sequence variations from dbSNP and Humsavar for DCAF12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000004023 -- 34,099,265(+) GGAGT(A/C)TTGCT intron-variant
rs1000014640 -- 34,112,143(+) AACTC(-/AA)AAAAA intron-variant
rs1000056595 -- 34,099,522(+) CCACC(A/G)CGCCT intron-variant
rs1000108798 -- 34,103,231(+) ATGTT(G/T)TAAGC intron-variant
rs1000132983 -- 34,109,921(+) CATTG(C/T)AGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF12 Gene

Variant ID Type Subtype PubMed ID
dgv1336e199 CNV deletion 23128226
esv1229280 CNV insertion 17803354
esv2676427 CNV deletion 23128226
esv3573225 CNV loss 25503493
esv3573226 CNV loss 25503493
esv3620335 CNV gain 21293372
esv3620345 CNV gain 21293372
esv3620346 CNV loss 21293372
nsv1023129 CNV gain 25217958
nsv1030732 CNV gain 25217958
nsv1110012 CNV deletion 24896259
nsv1125318 OTHER inversion 24896259
nsv509300 CNV insertion 20534489
nsv520467 CNV gain 19592680
nsv614154 CNV loss 21841781
nsv6525 CNV deletion 18451855
nsv819806 CNV gain 19587683

Variation tolerance for DCAF12 Gene

Residual Variation Intolerance Score: 47.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.42; 85.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF12 Gene

Disorders for DCAF12 Gene

Relevant External Links for DCAF12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DCAF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF12 Gene

Publications for DCAF12 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 3 4 64
  3. Novel centrosome protein, TCC52, is a cancer-testis antigen. (PMID: 18957058) Li S. … He D. (Cancer Sci. 2008) 3 4 64
  4. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4 64
  5. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 3 64

Products for DCAF12 Gene

Sources for DCAF12 Gene

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