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Aliases for DCAF12 Gene

Aliases for DCAF12 Gene

  • DDB1 And CUL4 Associated Factor 12 2 3
  • KIAA1892 2 3 4
  • Testis Cancer Centrosome-Related Protein 3 4
  • Centrosome-Related Protein TCC52 3 4
  • WD Repeat-Containing Protein 40A 3 4
  • Cancer/Testis Antigen 102 2 3
  • WD Repeat Domain 40A 2 3
  • WDR40A 3 4
  • TCC52 3 4
  • CT102 3

External Ids for DCAF12 Gene

Previous HGNC Symbols for DCAF12 Gene

  • KIAA1892
  • WDR40A

Summaries for DCAF12 Gene

Entrez Gene Summary for DCAF12 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF12 Gene

DCAF12 (DDB1 And CUL4 Associated Factor 12) is a Protein Coding gene. An important paralog of this gene is DCAF12L1.

UniProtKB/Swiss-Prot for DCAF12 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF12 Gene

Genomics for DCAF12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DCAF12 Gene

Chromosome:
9
Start:
34,086,383 bp from pter
End:
34,127,399 bp from pter
Size:
41,017 bases
Orientation:
Minus strand

Genomic View for DCAF12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF12 Gene

No data available for Regulatory Elements for DCAF12 Gene

Proteins for DCAF12 Gene

  • Protein details for DCAF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T6F0-DCA12_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 12
    Protein Accession:
    Q5T6F0
    Secondary Accessions:
    • A8KA70
    • D3DRL6
    • Q5T6E9
    • Q5T6F1
    • Q6P3V0
    • Q7L4F8
    • Q96PZ5
    • Q9NXA9
    • Q9UFJ1

    Protein attributes for DCAF12 Gene

    Size:
    453 amino acids
    Molecular mass:
    50517 Da
    Quaternary structure:
    • Interacts with DDB1.
    SequenceCaution:
    • Sequence=BAA91106.1; Type=Frameshift; Positions=27; Evidence={ECO:0000305}; Sequence=BAB67785.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI15300.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15302.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DCAF12 Gene

neXtProt entry for DCAF12 Gene

Proteomics data for DCAF12 Gene at MOPED

Post-translational modifications for DCAF12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DCAF12 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for DCAF12

No data available for DME Specific Peptides for DCAF12 Gene

Domains & Families for DCAF12 Gene

Protein Domains for DCAF12 Gene

Suggested Antigen Peptide Sequences for DCAF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T6F0

UniProtKB/Swiss-Prot:

DCA12_HUMAN :
  • Belongs to the WD repeat DCAF12 family.
  • Contains 6 WD repeats.
Family:
  • Belongs to the WD repeat DCAF12 family.
Similarity:
  • Contains 6 WD repeats.
genes like me logo Genes that share domains with DCAF12: view

Function for DCAF12 Gene

Molecular function for DCAF12 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with DCAF12: view

Phenotypes for DCAF12 Gene

genes like me logo Genes that share phenotypes with DCAF12: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF12

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for DCAF12 Gene

Localization for DCAF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DCAF12 Gene

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF12 Gene COMPARTMENTS Subcellular localization image for DCAF12 gene
Compartment Confidence
cytoskeleton 5

Gene Ontology (GO) - Cellular Components for DCAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18957058
GO:0005813 centrosome IDA 18957058
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF12: view

Pathways & Interactions for DCAF12 Gene

SuperPathways for DCAF12 Gene

No Data Available

UniProtKB/Swiss-Prot Q5T6F0-DCA12_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for DCAF12 Gene

Gene Ontology (GO) - Biological Process for DCAF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF12: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF12 Gene

Drugs & Compounds for DCAF12 Gene

No Compound Related Data Available

Transcripts for DCAF12 Gene

Unigene Clusters for DCAF12 Gene

DDB1 and CUL4 associated factor 12:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DCAF12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF12 Gene

No ASD Table

Relevant External Links for DCAF12 Gene

GeneLoc Exon Structure for
DCAF12
ECgene alternative splicing isoforms for
DCAF12

Expression for DCAF12 Gene

mRNA expression in normal human tissues for DCAF12 Gene

mRNA differential expression in normal tissues according to GTEx for DCAF12 Gene

This gene is overexpressed in Whole Blood (x9.0).

Protein differential expression in normal tissues from HIPED for DCAF12 Gene

This gene is overexpressed in Synovial fluid (63.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF12 Gene



SOURCE GeneReport for Unigene cluster for DCAF12 Gene Hs.493750

mRNA Expression by UniProt/SwissProt for DCAF12 Gene

Q5T6F0-DCA12_HUMAN
Tissue specificity: Highly expressed in lung cancer tissues and some cancer cell lines. Restricted expression in normal testis.
genes like me logo Genes that share expression patterns with DCAF12: view

Protein tissue co-expression partners for DCAF12 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DCAF12 Gene

Orthologs for DCAF12 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCAF12 35
  • 93.89 (n)
  • 98.01 (a)
DCAF12 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF12 35
  • 94.19 (n)
  • 99.34 (a)
DCAF12 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf12 35
  • 91.61 (n)
  • 98.45 (a)
Dcaf12 16
Dcaf12 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCAF12 35
  • 99.77 (n)
  • 99.31 (a)
DCAF12 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC682812 35
  • 83.22 (n)
  • 88.29 (a)
oppossum
(Monodelphis domestica)
Mammalia DCAF12 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF12 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF12 35
  • 80.5 (n)
  • 91.27 (a)
DCAF12 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF12 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf12 35
  • 73.69 (n)
  • 80.04 (a)
MGC76023 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.3728 35
zebrafish
(Danio rerio)
Actinopterygii dcaf12 35
  • 68.83 (n)
  • 77.35 (a)
dcaf12 36
  • 70 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002260 35
  • 51.74 (n)
  • 47.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3313 35
  • 51.2 (n)
  • 43.75 (a)
CG3313 36
  • 38 (a)
OneToMany
Species with no ortholog for DCAF12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF12 Gene

ENSEMBL:
Gene Tree for DCAF12 (if available)
TreeFam:
Gene Tree for DCAF12 (if available)

Paralogs for DCAF12 Gene

Paralogs for DCAF12 Gene

(2) SIMAP similar genes for DCAF12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DCAF12: view

Variants for DCAF12 Gene

Sequence variations from dbSNP and Humsavar for DCAF12 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1378 -- 34,107,506(-) GACCG(A/G)GAGCC synonymous-codon, reference, utr-variant-5-prime
rs1052656 -- 34,087,362(-) CCCCC(A/G)TGGCT utr-variant-3-prime
rs1052694 -- 34,086,582(-) GATTT(C/T)TTAGT utr-variant-3-prime
rs1980886 -- 34,101,103(-) CAGAG(C/T)CAGAA intron-variant
rs1980887 -- 34,100,919(-) GCTCA(C/T)GCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF12 Gene

Variant ID Type Subtype PubMed ID
nsv893028 CNV Gain 21882294
nsv520467 CNV Gain 19592680
nsv893030 CNV Gain 21882294
nsv893033 CNV Gain 21882294
nsv6525 CNV Loss 18451855
nsv819806 CNV Gain 19587683
dgv1336e199 CNV Deletion 23128226
nsv509300 CNV Insertion 20534489
esv2676427 CNV Deletion 23128226
esv1229280 CNV Insertion 17803354

Variation tolerance for DCAF12 Gene

Residual Variation Intolerance Score: 47.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.42; 85.61% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF12 Gene

HapMap Linkage Disequilibrium report
DCAF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF12 Gene

Disorders for DCAF12 Gene

Relevant External Links for DCAF12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF12
genes like me logo Genes that share disorders with DCAF12: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF12 Gene

Publications for DCAF12 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 67
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T. … Ohara O. (DNA Res. 2001) 2 67
  3. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 67
  4. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 67
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 67

Products for DCAF12 Gene

Sources for DCAF12 Gene

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