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Aliases for DCAF11 Gene

Aliases for DCAF11 Gene

  • DDB1 And CUL4 Associated Factor 11 2 3 5
  • WD Repeat-Containing Protein 23 3 4
  • WD Repeat Domain 23 2 3
  • WDR23 3 4
  • PRO2389 3
  • GL014 3

External Ids for DCAF11 Gene

Previous HGNC Symbols for DCAF11 Gene

  • WDR23

Previous GeneCards Identifiers for DCAF11 Gene

  • GC14P023655
  • GC14P024583
  • GC14P004699

Summaries for DCAF11 Gene

Entrez Gene Summary for DCAF11 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF11 Gene

DCAF11 (DDB1 And CUL4 Associated Factor 11) is a Protein Coding gene. An important paralog of this gene is ENSG00000259371.

UniProtKB/Swiss-Prot for DCAF11 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF11 Gene

Genomics for DCAF11 Gene

Regulatory Elements for DCAF11 Gene

Enhancers for DCAF11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DCAF11 on UCSC Golden Path with GeneCards custom track

Promoters for DCAF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DCAF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for DCAF11 Gene

Chromosome:
14
Start:
24,114,195 bp from pter
End:
24,125,242 bp from pter
Size:
11,048 bases
Orientation:
Plus strand

Genomic View for DCAF11 Gene

Genes around DCAF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF11 Gene

Proteins for DCAF11 Gene

  • Protein details for DCAF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEB1-DCA11_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 11
    Protein Accession:
    Q8TEB1
    Secondary Accessions:
    • B3KQ83
    • D3DS56
    • Q5D039
    • Q86U00
    • Q86U39
    • Q8NDN2
    • Q9H2J0
    • Q9H3A3
    • Q9H5C9

    Protein attributes for DCAF11 Gene

    Size:
    546 amino acids
    Molecular mass:
    61670 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.
    SequenceCaution:
    • Sequence=AAG35498.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG44727.1; Type=Frameshift; Positions=514, 516, 519, 535; Evidence={ECO:0000305}; Sequence=BAB15698.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCAF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF11 Gene

Proteomics data for DCAF11 Gene at MOPED

Post-translational modifications for DCAF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DCAF11 Gene

Domains & Families for DCAF11 Gene

Suggested Antigen Peptide Sequences for DCAF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TEB1

UniProtKB/Swiss-Prot:

DCA11_HUMAN :
  • Contains 7 WD repeats.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF11: view

Function for DCAF11 Gene

Molecular function for DCAF11 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Phenotypes for DCAF11 Gene

genes like me logo Genes that share phenotypes with DCAF11: view

Animal Models for DCAF11 Gene

MGI Knock Outs for DCAF11:

Animal Model Products

CRISPR Products

miRNA for DCAF11 Gene

miRTarBase miRNAs that target DCAF11

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCAF11 Gene

Localization for DCAF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF11 Gene COMPARTMENTS Subcellular localization image for DCAF11 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF11 Gene

Pathways & Interactions for DCAF11 Gene

SuperPathways for DCAF11 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TEB1-DCA11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DCAF11 Gene

Drugs & Compounds for DCAF11 Gene

No Compound Related Data Available

Transcripts for DCAF11 Gene

Unigene Clusters for DCAF11 Gene

DDB1 and CUL4 associated factor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
SP1: - - - - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - -
SP13: -
SP14: - - -
SP15:
SP16: - - - - -
SP17: - - - - - - - - - -
SP18: - - -
SP19: - - - - -
SP20:
SP21: - -
SP22: - - -
SP23: - - - - -
SP24: - - - - - - - - -
SP25: - -

ExUns: 9d ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for DCAF11 Gene

GeneLoc Exon Structure for
DCAF11
ECgene alternative splicing isoforms for
DCAF11

Expression for DCAF11 Gene

mRNA expression in normal human tissues for DCAF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCAF11 Gene

This gene is overexpressed in Gallbladder (16.7), Blymphocyte (9.8), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF11 Gene



SOURCE GeneReport for Unigene cluster for DCAF11 Gene Hs.525251

genes like me logo Genes that share expression patterns with DCAF11: view

Protein tissue co-expression partners for DCAF11 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAF11 Gene

Orthologs for DCAF11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DCAF11 35
  • 92.19 (n)
  • 94.87 (a)
WDR23 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF11 35
  • 92.74 (n)
  • 95.79 (a)
DCAF11 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf11 35
  • 89.67 (n)
  • 93.95 (a)
Dcaf11 16
Dcaf11 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DCAF11 35
  • 99.63 (n)
  • 100 (a)
DCAF11 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf11 35
  • 89.98 (n)
  • 94.52 (a)
oppossum
(Monodelphis domestica)
Mammalia DCAF11 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF11 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf11 35
  • 69.36 (n)
  • 75.57 (a)
Str.3946 35
African clawed frog
(Xenopus laevis)
Amphibia wdr23-prov 35
zebrafish
(Danio rerio)
Actinopterygii dcaf11 35
  • 66.32 (n)
  • 69.52 (a)
dcaf11 36
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9945 35
  • 46.24 (n)
  • 38 (a)
CG9945 36
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea wdr-23 35
  • 50.28 (n)
  • 44.38 (a)
wdr-23 36
  • 32 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os05g0144100 35
  • 53.1 (n)
  • 49.04 (a)
Species with no ortholog for DCAF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAF11 Gene

ENSEMBL:
Gene Tree for DCAF11 (if available)
TreeFam:
Gene Tree for DCAF11 (if available)

Paralogs for DCAF11 Gene

Paralogs for DCAF11 Gene

genes like me logo Genes that share paralogs with DCAF11: view

Variants for DCAF11 Gene

Sequence variations from dbSNP and Humsavar for DCAF11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3825584 - 24,118,430(+) TTTCC(A/G)TAAAT nc-transcript-variant, reference, missense
rs7141186 -- 24,124,035(+) GCTCA(A/G)TGTCT nc-transcript-variant, utr-variant-3-prime
rs762093 -- 24,122,709(-) ATGCA(C/G)TGGCT intron-variant
rs3742499 -- 24,117,624(+) AGTGG(C/T)CCTCT intron-variant
rs8009511 -- 24,124,771(+) gcacg(A/G)tggtt nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DCAF11 Gene

Variant ID Type Subtype PubMed ID
nsv901498 CNV Loss 21882294

Variation tolerance for DCAF11 Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.83; 91.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF11 Gene

Human Gene Mutation Database (HGMD)
DCAF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF11 Gene

Disorders for DCAF11 Gene

Relevant External Links for DCAF11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF11

No disorders were found for DCAF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF11 Gene

Publications for DCAF11 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 3 4 67
  2. Reversible oxidation of phosphatase and tensin homolog (PTEN) alters its interactions with signaling and regulatory proteins. (PMID: 26561776) Verrastro I. … Pitt A.R. (Free Radic. Biol. Med. 2016) 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3

Products for DCAF11 Gene

Sources for DCAF11 Gene

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