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Aliases for DCAF11 Gene

Aliases for DCAF11 Gene

  • DDB1 And CUL4 Associated Factor 11 2 3 5
  • WD Repeat-Containing Protein 23 3 4
  • WD Repeat Domain 23 2 3
  • WDR23 3 4
  • DDB1- And CUL4-Associated Factor 11 3
  • PRO2389 3
  • GL014 3

External Ids for DCAF11 Gene

Previous HGNC Symbols for DCAF11 Gene

  • WDR23

Previous GeneCards Identifiers for DCAF11 Gene

  • GC14P023655
  • GC14P024583
  • GC14P004699

Summaries for DCAF11 Gene

Entrez Gene Summary for DCAF11 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF11 Gene

DCAF11 (DDB1 And CUL4 Associated Factor 11) is a Protein Coding gene. An important paralog of this gene is ENSG00000259371.

UniProtKB/Swiss-Prot for DCAF11 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF11 Gene

Genomics for DCAF11 Gene

Regulatory Elements for DCAF11 Gene

Enhancers for DCAF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G024091 1.7 Ensembl ENCODE dbSUPER 11.4 -20.5 -20549 6.5 MLX AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 SP3 RNA5SP383 KHNYN CARMIL3 C14orf119 NYNRIN NRL DCAF11 TM9SF1 IPO4 IRF9
GH14G024090 0.8 ENCODE dbSUPER 11.4 -23.9 -23909 0.2 ZGPAT ZNF792 MAFK EZH2 NRL DCAF11 CARMIL3 IRF9 IPO4 TM9SF1 TSSK4 PCK2 CPNE6
GH14G024086 0.4 FANTOM5 11.4 -27.5 -27460 0.2 TEAD3 NRL CARMIL3 DCAF11 IRF9 IPO4 TM9SF1 TSSK4 PCK2 CPNE6
GH14G024240 1.7 FANTOM5 ENCODE dbSUPER 1.8 +128.0 128046 3.8 PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 KHNYN RNA5SP383 LOC102724814 NYNRIN ENSG00000259321 TGM1 IRF9 TINF2 PSME1 RNF31
GH14G024270 1.5 FANTOM5 ENCODE 1.4 +158.6 158631 5.4 HDGF PKNOX1 MLX ARNT CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 DHRS1 TINF2 LTB4R KHNYN NEDD8-MDP1 NEDD8 NOP9 GMPR2 MDP1 ENSG00000254692
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DCAF11 on UCSC Golden Path with GeneCards custom track

Promoters for DCAF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066828 506 2600 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for DCAF11 Gene

Chromosome:
14
Start:
24,114,195 bp from pter
End:
24,125,242 bp from pter
Size:
11,048 bases
Orientation:
Plus strand

Genomic View for DCAF11 Gene

Genes around DCAF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF11 Gene

Proteins for DCAF11 Gene

  • Protein details for DCAF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEB1-DCA11_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 11
    Protein Accession:
    Q8TEB1
    Secondary Accessions:
    • B3KQ83
    • D3DS56
    • Q5D039
    • Q86U00
    • Q86U39
    • Q8NDN2
    • Q9H2J0
    • Q9H3A3
    • Q9H5C9

    Protein attributes for DCAF11 Gene

    Size:
    546 amino acids
    Molecular mass:
    61670 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.
    SequenceCaution:
    • Sequence=AAG35498.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG44727.1; Type=Frameshift; Positions=514, 516, 519, 535; Evidence={ECO:0000305}; Sequence=BAB15698.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCAF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF11 Gene

Post-translational modifications for DCAF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DCAF11 Gene

Domains & Families for DCAF11 Gene

Suggested Antigen Peptide Sequences for DCAF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DCAF11: view

No data available for UniProtKB/Swiss-Prot for DCAF11 Gene

Function for DCAF11 Gene

Molecular function for DCAF11 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with DCAF11: view
genes like me logo Genes that share phenotypes with DCAF11: view

Animal Models for DCAF11 Gene

MGI Knock Outs for DCAF11:

Animal Model Products

CRISPR Products

miRNA for DCAF11 Gene

miRTarBase miRNAs that target DCAF11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCAF11 Gene

Localization for DCAF11 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DCAF11 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS,IDA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF11 Gene

Pathways & Interactions for DCAF11 Gene

SuperPathways for DCAF11 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TEB1-DCA11_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043687 post-translational protein modification TAS --
genes like me logo Genes that share ontologies with DCAF11: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF11 Gene

Transcripts for DCAF11 Gene

Unigene Clusters for DCAF11 Gene

DDB1 and CUL4 associated factor 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
SP1: - - - - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - -
SP13: -
SP14: - - -
SP15:
SP16: - - - - -
SP17: - - - - - - - - - -
SP18: - - -
SP19: - - - - -
SP20:
SP21: - -
SP22: - - -
SP23: - - - - -
SP24: - - - - - - - - -
SP25: - -

ExUns: 9d ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for DCAF11 Gene

GeneLoc Exon Structure for
DCAF11
ECgene alternative splicing isoforms for
DCAF11

Expression for DCAF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DCAF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DCAF11 Gene

This gene is overexpressed in Gallbladder (16.7), Blymphocyte (9.8), and Pancreas (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCAF11 Gene



Protein tissue co-expression partners for DCAF11 Gene

NURSA nuclear receptor signaling pathways regulating expression of DCAF11 Gene:

DCAF11

SOURCE GeneReport for Unigene cluster for DCAF11 Gene:

Hs.525251

Evidence on tissue expression from TISSUES for DCAF11 Gene

  • Nervous system(5)
  • Liver(4.7)
  • Eye(4.3)
  • Lung(4.3)
  • Kidney(2.7)
  • Skin(2.2)
genes like me logo Genes that share expression patterns with DCAF11: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DCAF11 Gene

Orthologs for DCAF11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF11 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia WDR23 35
  • 95 (a)
OneToOne
DCAF11 34
  • 92.19 (n)
dog
(Canis familiaris)
Mammalia DCAF11 34 35
  • 92.74 (n)
rat
(Rattus norvegicus)
Mammalia Dcaf11 34
  • 89.98 (n)
mouse
(Mus musculus)
Mammalia Dcaf11 34 16 35
  • 89.67 (n)
oppossum
(Monodelphis domestica)
Mammalia DCAF11 35
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DCAF11 35
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf11 34
  • 69.36 (n)
Str.3946 34
African clawed frog
(Xenopus laevis)
Amphibia wdr23-prov 34
zebrafish
(Danio rerio)
Actinopterygii dcaf11 34 35
  • 66.32 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG9945 34 35
  • 46.24 (n)
worm
(Caenorhabditis elegans)
Secernentea wdr-23 34 35
  • 50.28 (n)
rice
(Oryza sativa)
Liliopsida Os05g0144100 34
  • 53.1 (n)
Species where no ortholog for DCAF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAF11 Gene

ENSEMBL:
Gene Tree for DCAF11 (if available)
TreeFam:
Gene Tree for DCAF11 (if available)

Paralogs for DCAF11 Gene

Paralogs for DCAF11 Gene

genes like me logo Genes that share paralogs with DCAF11: view

Variants for DCAF11 Gene

Sequence variations from dbSNP and Humsavar for DCAF11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000079743 -- 24,116,661(+) AATGA(C/T)GTTAG intron-variant, upstream-variant-2KB
rs1000139909 -- 24,113,970(+) AGCCA(G/T)GGCGA intron-variant, upstream-variant-2KB
rs1000679395 -- 24,118,027(+) CCCCT(C/T)ACCCT intron-variant
rs1000748812 -- 24,124,871(+) ACCCA(A/G)TCTCT nc-transcript-variant, utr-variant-3-prime
rs1000951440 -- 24,124,560(+) GTGTT(C/G)ACAGG nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DCAF11 Gene

Variant ID Type Subtype PubMed ID
nsv564057 CNV loss 21841781

Variation tolerance for DCAF11 Gene

Residual Variation Intolerance Score: 52.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.83; 91.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF11 Gene

Human Gene Mutation Database (HGMD)
DCAF11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF11 Gene

Disorders for DCAF11 Gene

Relevant External Links for DCAF11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF11

No disorders were found for DCAF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF11 Gene

Publications for DCAF11 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 3 4 64
  2. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64

Products for DCAF11 Gene

Sources for DCAF11 Gene

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