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Aliases for DCAF11 Gene

Aliases for DCAF11 Gene

  • DDB1 And CUL4 Associated Factor 11 2 3
  • WDR23 3 4 6
  • WD Repeat-Containing Protein 23 3 4
  • WD Repeat Domain 23 2 3
  • DDB1- And CUL4-Associated Factor 11 3
  • PRO2389 3
  • GL014 3

External Ids for DCAF11 Gene

Previous Symbols for DCAF11 Gene

  • WDR23

Summaries for DCAF11 Gene

Entrez Gene Summary for DCAF11 Gene

  • This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

GeneCards Summary for DCAF11 Gene

DCAF11 (DDB1 And CUL4 Associated Factor 11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCAF11 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF11 Gene

Genomics for DCAF11 Gene

Genomic Location for DCAF11 Gene

Start:
24,114,195 bp from pter
End:
24,125,242 bp from pter
Size:
11,048 bases
Orientation:
Plus strand

Genomic View for DCAF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DCAF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF11 Gene

No data available for Regulatory Elements for DCAF11 Gene

Proteins for DCAF11 Gene

  • Protein details for DCAF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TEB1-DCA11_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 11
    Protein Accession:
    Q8TEB1
    Secondary Accessions:
    • B3KQ83
    • D3DS56
    • Q5D039
    • Q86U00
    • Q86U39
    • Q8NDN2
    • Q9H2J0
    • Q9H3A3
    • Q9H5C9

    Protein attributes for DCAF11 Gene

    Size:
    546 amino acids
    Molecular mass:
    61670 Da
    Quaternary structure:
    • Interacts with DDB1 and CUL4A.
    SequenceCaution:
    • Sequence=AAG35498.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAG44727.1; Type=Frameshift; Positions=514, 516, 519, 535; Evidence={ECO:0000305}; Sequence=BAB15698.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCAF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF11 Gene

Proteomics data for DCAF11 Gene at MOPED

Post-translational modifications for DCAF11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DCAF11 Gene

Domains for DCAF11 Gene

Gene Families for DCAF11 Gene

HGNC:
  • WDR :WD repeat domain containing
  • DCAF :DDB1 and CUL4 associated factors

UniProtKB/Swiss-Prot:

DCA11_HUMAN
Similarity:
  • Contains 7 WD repeats.:
    • Q8TEB1
genes like me logo Genes that share domains with DCAF11: view

Function for DCAF11 Gene

Molecular function for DCAF11 Gene

UniProtKB/Swiss-Prot Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

Gene Ontology (GO) - Molecular Function for DCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22190034
genes like me logo Genes that share ontologies with DCAF11: view

miRNA for DCAF11 Gene

miRTarBase miRNAs that target DCAF11

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DCAF11 Gene

Localization for DCAF11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF11 Gene COMPARTMENTS Subcellular localization image for DCAF11 gene
Compartment Confidence
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF11: view

Pathways for DCAF11 Gene

SuperPathways for DCAF11 Gene

No Data Available

UniProtKB/Swiss-Prot Q8TEB1-DCA11_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for DCAF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF11: view

No data available for Pathways by source for DCAF11 Gene

Transcripts for DCAF11 Gene

Unigene Clusters for DCAF11 Gene

DDB1 and CUL4 associated factor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF11 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
SP1: - - - - - - - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - - - - - - - -
SP6:
SP7:
SP8:
SP9: - - - - - - - - - - - - -
SP10: - - - - - - -
SP11: - - -
SP12: - - - -
SP13: -
SP14: - - -
SP15:
SP16: - - - - -
SP17: - - - - - - - - - -
SP18: - - -
SP19: - - - - -
SP20:
SP21: - -
SP22: - - -
SP23: - - - - -
SP24: - - - - - - - - -
SP25: - -

ExUns: 9d ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6:
SP7: -
SP8: -
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:
SP24:
SP25:

Relevant External Links for DCAF11 Gene

GeneLoc Exon Structure for
DCAF11
ECgene alternative splicing isoforms for
DCAF11

Expression for DCAF11 Gene

mRNA expression in normal human tissues for DCAF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DCAF11 Gene

SOURCE GeneReport for Unigene cluster for DCAF11 Gene Hs.525251

genes like me logo Genes that share expressions with DCAF11: view

Orthologs for DCAF11 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DCAF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF11 36
  • 99.63 (n)
  • 100 (a)
DCAF11 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DCAF11 36
  • 92.19 (n)
  • 94.87 (a)
WDR23 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DCAF11 36
  • 92.74 (n)
  • 95.79 (a)
DCAF11 37
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dcaf11 36
  • 89.67 (n)
  • 93.95 (a)
Dcaf11 16
Dcaf11 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAF11 37
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dcaf11 36
  • 89.98 (n)
  • 94.52 (a)
lizard
(Anolis carolinensis)
Reptilia DCAF11 37
  • 78 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia wdr23-prov 36
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf11 36
  • 69.36 (n)
  • 75.57 (a)
Str.3946 36
zebrafish
(Danio rerio)
Actinopterygii dcaf11 36
  • 66.32 (n)
  • 69.52 (a)
dcaf11 37
  • 64 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG9945 36
  • 46.24 (n)
  • 38 (a)
CG9945 37
  • 32 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea wdr-23 36
  • 50.28 (n)
  • 44.38 (a)
wdr-23 37
  • 32 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os05g0144100 36
  • 53.1 (n)
  • 49.04 (a)
Species with no ortholog for DCAF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DCAF11 Gene

ENSEMBL:
Gene Tree for DCAF11 (if available)
TreeFam:
Gene Tree for DCAF11 (if available)

Paralogs for DCAF11 Gene

No data available for Paralogs for DCAF11 Gene

Variants for DCAF11 Gene

Sequence variations from dbSNP and Humsavar for DCAF11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs762093 -- 24,122,709(-) ATGCA(C/G)TGGCT intron-variant
rs1134334 -- 24,124,905(+) cggat(A/G)tggtg utr-variant-3-prime, nc-transcript-variant
rs1134340 -- 24,125,004(+) caaga(C/T)catgc utr-variant-3-prime, nc-transcript-variant
rs2277479 -- 24,118,295(+) AAGGG(A/G)AGACT intron-variant
rs2277480 -- 24,118,306(+) CCACA(A/G)GTACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF11 Gene

Variant ID Type Subtype PubMed ID
nsv901498 CNV Loss 21882294

Relevant External Links for DCAF11 Gene

HapMap Linkage Disequilibrium report
DCAF11
Human Gene Mutation Database (HGMD)
DCAF11

Disorders for DCAF11 Gene

No disorders were found for DCAF11 Gene.

No data available for UniProtKB/Swiss-Prot for DCAF11 Gene

Publications for DCAF11 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4
  2. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PMID: 16964240) Angers S. … Zheng N. (Nature 2006) 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DCAF11 Gene

Sources for DCAF11 Gene

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