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DCAF11 Gene

protein-coding   GIFtS: 47
GCID: GC14P024583

DDB1 And CUL4 Associated Factor 11

(Previous name: WD repeat domain 23)
(Previous symbol: WDR23)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DDB1 And CUL4 Associated Factor 111 2
WDR231 2 3 5
WD Repeat Domain 231 2
WD Repeat-Containing Protein 232 3
PRO23892
DDB1- And CUL4-Associated Factor 112

External Ids:    HGNC: 202581   Entrez Gene: 803442   Ensembl: ENSG000001008977   OMIM: 6133175   UniProtKB: Q8TEB13   

Export aliases for DCAF11 gene to outside databases

Previous GC identifers: GC14P023655 GC14P004699


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DCAF11 Gene:
This gene encodes a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular
complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8
conjugates. Multiple alternatively spliced transcript variants have been found for this gene. (provided by
RefSeq, Jul 2009)

GeneCards Summary for DCAF11 Gene:
DCAF11 (DDB1 and CUL4 associated factor 11) is a protein-coding gene. Diseases associated with DCAF11 include hiv-1.

UniProtKB/Swiss-Prot: DCA11_HUMAN, Q8TEB1
Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for DCAF11
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCAF11 promoter sequence
   Search Chromatin IP Primers for DCAF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DCAF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DCAF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF11 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P024583:  view genomic region     (about GC identifiers)

Start:
24,583,404 bp from pter      End:
24,594,451 bp from pter
Size:
11,048 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DCAF11

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DCA11_HUMAN, Q8TEB1 (See protein sequence)
Recommended Name: DDB1- and CUL4-associated factor 11  
Size: 546 amino acids; 61670 Da
Subunit: Interacts with DDB1 and CUL4A
Sequence caution: Sequence=AAG35498.1; Type=Erroneous initiation; Sequence=AAG44727.1; Type=Frameshift;
Positions=514, 516, 519, 535; Sequence=BAB15698.1; Type=Erroneous initiation;
Secondary accessions: B3KQ83 D3DS56 Q5D039 Q86U00 Q86U39 Q8NDN2 Q9H2J0 Q9H3A3 Q9H5C9
Alternative splicing: 3 isoforms:  Q8TEB1-1   Q8TEB1-2   Q8TEB1-3   

Explore the universe of human proteins at neXtProt for DCAF11: NX_Q8TEB1

Explore proteomics data for DCAF11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DCAF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001156956.1  NP_079506.3  NP_852002.1  

    ENSEMBL proteins: 
     ENSP00000453470   ENSP00000452898   ENSP00000454044   ENSP00000453074   ENSP00000453916  
     ENSP00000415556   ENSP00000453462   ENSP00000453381   ENSP00000453208   ENSP00000453132  
     ENSP00000453587   ENSP00000453678   ENSP00000453290   ENSP00000453814   ENSP00000453803  
     ENSP00000453632   ENSP00000453505   ENSP00000454129   ENSP00000454139   ENSP00000323680  
     ENSP00000453805   ENSP00000453550   ENSP00000453832   ENSP00000453826   ENSP00000452915  
     ENSP00000453035   ENSP00000380146   ENSP00000453184   ENSP00000380142   ENSP00000453115  

    DCAF11 Human Recombinant Protein Products:

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    Novus Biologicals DCAF11 Protein
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    DCAF11 Assay Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    5 InterPro protein domains:
     IPR017399 WD_repeat_p23
     IPR001680 WD40_repeat
     IPR020472 G-protein_beta_WD-40_rep
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TEB1

    ProtoNet protein and cluster: Q8TEB1

    UniProtKB/Swiss-Prot: DCA11_HUMAN, Q8TEB1
    Similarity: Contains 7 WD repeats


    DCAF11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCA11_HUMAN, Q8TEB1
    Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI--
         
    DCAF11 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DCAF11
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DCAF11

    miRNA
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    miRTarBase miRNAs that target DCAF11:
    hsa-mir-346 (MIRT042700), hsa-mir-320a (MIRT044841)

    Block miRNA regulation of human, mouse, rat DCAF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF11 (see all 30):
    hsa-miR-1321 hsa-miR-185* hsa-miR-1260b hsa-miR-575 hsa-miR-765 hsa-miR-449a hsa-miR-609 hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidDCAF11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DCAF11

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): DCAF11 (NM_025230)
    Sino Biological Human cDNA Clone for DCAF11
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF11

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0080008Cul4-RING ubiquitin ligase complex IDA16949367

    DCAF11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: DCA11_HUMAN, Q8TEB1
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DCAF11
    Interactions:

        Search GeneGlobe Interaction Network for DCAF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DCAF11 (Q8TEB11, 3 ENSP000003236804) via UniProtKB, MINT, STRING, and/or I2D (see all 41)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    COPS5Q929053, ENSP000003505124I2D: score=2 STRING: ENSP00000350512
    PARP11Q9NR213, ENSP000002288204I2D: score=2 STRING: ENSP00000228820
    DDB1Q165313, ENSP000003017644I2D: score=3 STRING: ENSP00000301764
    COPS6Q7L5N13, ENSP000003041024I2D: score=2 STRING: ENSP00000304102
    CUL4AQ136193, ENSP000003645894I2D: score=1 STRING: ENSP00000364589
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    DCAF11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DCAF11 (DCA11)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DCAF11 gene (3 alternative transcripts): 
    NM_001163484.1  NM_025230.4  NM_181357.2  

    Unigene Cluster for DCAF11:

    DDB1 and CUL4 associated factor 11
    Hs.525251  [show with all ESTs]
    Unigene Representative Sequence: NM_025230
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 38):
    ENST00000559017 ENST00000561056 ENST00000559115 ENST00000558215 ENST00000557809
    ENST00000557810 ENST00000561375 ENST00000446197(uc001wlv.3 uc001wlw.3 uc001wlz.3 uc001wly.3 uc010tny.2 uc001wmc.3 uc001wmb.4 uc001wma.4)
    ENST00000557802 ENST00000559796 ENST00000560713 ENST00000560901 ENST00000559382
    ENST00000561001 ENST00000559396 ENST00000560457 ENST00000558706 ENST00000561016

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DCAF11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DCAF11 (see all 30):
    hsa-miR-1321 hsa-miR-185* hsa-miR-1260b hsa-miR-575 hsa-miR-765 hsa-miR-449a hsa-miR-609 hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidDCAF11 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DCAF11
    Predesigned siRNA for gene silencing in human, mouse, rat DCAF11
    Clone
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    OriGene clones in human, mouse for DCAF11 (see all 19)
    OriGene ORF clones in mouse, rat for DCAF11
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DCAF11 (NM_025230)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DCAF11
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF11
    Primer
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    OriGene qPCR primer pairs and template standards for DCAF11
    OriGene qSTAR qPCR primer pairs in human, mouse for DCAF11
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DCAF11
      QuantiTect SYBR Green Assays in human, mouse, rat DCAF11
      QuantiFast Probe-based Assays in human, mouse, rat DCAF11

    Additional mRNA sequence: 

    AB209073.1 AF130070.1 AF267858.1 AF283773.2 AK027223.1 AK057636.1 AK074296.1 AK094478.1 
    AK292797.1 AK296742.1 AK307849.1 AL833831.1 BC008858.2 BC067132.1 BX161405.1 BX247970.1 
    BX648224.1 NR_028099.1 NR_028100.1 

    Selected DOTS entries (see all 44):

    DT.100800736  DT.100803170  DT.312352  DT.117168  DT.92410643  DT.100866229  DT.92464285  DT.100866220 
    DT.100866231  DT.92464288  DT.120792065  DT.91850921  DT.100866221  DT.95361584  DT.100775953  DT.95320451 
    DT.91860627  DT.100866236  DT.120792296  DT.120792127  DT.100769101  DT.120792179  DT.120792297  DT.95361582 

    Selected AceView cDNA sequences (see all 382):

    BP345759 BU167583 BM474303 BM451597 AL599515 BX326501 CB164358 BM716221 
    BU784666 F09253 BU188056 BQ574746 F25446 BE275544 BX161405 AF283773 
    BM846447 BU173185 CB994436 BQ894832 AK074296 AW003607 BX463696 AI684379 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DCAF11 (see all 25)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d · 2e ^ 3a · 3b · 3c ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c ·
    SP1:                    -     -     -     -     -     -     -     -     -                                                                                       
    SP2:                                                  -     -                                                                                                   
    SP3:                                                                    -           -     -                                                                     
    SP4:                                                                                -                                                                           
    SP5:                    -     -     -     -     -     -     -     -                 -                                                                           

    ExUns: 9d ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b
    SP1:              -                 -                                             
    SP2:              -                 -                                             
    SP3:              -                 -                                             
    SP4:              -                 -                                             
    SP5:                                                                              


    ECgene alternative splicing isoforms for DCAF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DCAF11 expression in normal human tissues (normalized intensities)      DCAF11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGAGGCAC
    DCAF11 Expression
    About this image


    DCAF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Thyroid (Endocrine System)
     
     Liver (Hepatobiliary System)
     
     Adrenal Gland (Endocrine System)
     
     Kidney (Urinary System)
    DCAF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DCAF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.525251
        Custom PCR Arrays for DCAF11
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DCAF11
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DCAF11 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcaf111 , 5 DDB1 and CUL4 associated factor 111, 5 89.67(n)1
    93.95(a)1
      14 (28.19 cM)5
    281991  NM_133734.31  NP_598495.11 
     555600065 
    lizard
    (Anolis carolinensis)
    Reptilia DCAF116
    DDB1 and CUL4 associated factor 11
    78(a)
    1 ↔ 1
    GL344031.1(42208-55425)
    African clawed frog
    (Xenopus laevis)
    Amphibia wdr23-prov2 WD repeat domain 23 75.22(n)    BC045232.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dcaf111 ddb1 and cul4 associated factor 11 66.32(n)
    69.52(a)
      567578  NM_001031675.1  NP_001026845.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG99451 CG9945 46.24(n)
    38(a)
      37329  NM_166403.1  NP_725981.1 
    worm
    (Caenorhabditis elegans)
    Secernentea wdr-231 wdr-23 50.28(n)
    44.38(a)
      172518  NM_059724.3  NP_492125.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g01441001 Os05g0144100 53.1(n)
    49.04(a)
      4337782  NM_001061157.1  NP_001054622.1 


    ENSEMBL Gene Tree for DCAF11 (if available)
    TreeFam Gene Tree for DCAF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DCAF11 (see all 337)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840457171,2
    --24582753(+) ATGGGC/TGCCCA 5 -- us2k10--------
    rs1877683341,2
    --24582807(+) ATACCA/GGGCAC 5 -- us2k10--------
    rs766299171,2
    F--24582840(+) TTCAAG/CACCGT 5 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1115674881,2
    C,F--24582883(+) CCCTTC/TTAAGC 5 -- us2k11Minor allele frequency- T:0.50WA 2
    rs792542531,2
    C,F--24582996(+) AGAGGC/TCCCAG 5 -- us2k11Minor allele frequency- T:0.09WA 118
    rs1907349251,2
    --24583093(+) GCAGGC/TTGCAG 5 -- us2k10--------
    rs101380061,2
    C,F,H--24583168(+) CGTCCC/TCACCC 5 -- us2k112Minor allele frequency- T:0.04NS EA NA WA 1828
    rs1386621691,2
    --24583169(+) GTCCCA/CACCCA 5 -- us2k10--------
    rs1132149051,2
    C--24583247(+) CAGGAG/-GGGGC 5 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1181469931,2
    C,F--24583250(+) GAGGGG/AGCAGG 5 -- us2k11Minor allele frequency- A:0.01NA 120

    HapMap Linkage Disequilibrium report for DCAF11 (24583404 - 24594451 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for DCAF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901498CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DCAF11
    DNA2.0 Custom Variant and Variant Library Synthesis for DCAF11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613317    OMIM disorders: --

    1 disease for DCAF11:    About MalaCards
    hiv-1


    DCAF11 for disorders           About GeneDecksing


    Export disorders for DCAF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DCAF11 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with DCAF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (Mol. Cell 2006)
    2. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. (PubMed id 16964240)1, 2 Angers S.... Zheng N. (Nature 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)
    6. Vif hijacks CBF-I^ to degrade APOBEC3G and promote HIV-1 infection. (PubMed id 22190037)1 JAoger S....Krogan N.J. (Nature 2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 JAoger S....Krogan N.J. (Nature 2012)
    8. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    9. Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes. (PubMed id 22118674)1 Altun M....Kessler B.M. (amp 2011)
    10. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80344 HGNC: 20258 AceView: WDR23 Ensembl:ENSG00000100897 euGenes: HUgn80344
    ECgene: DCAF11 H-InvDB: DCAF11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DCAF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DCAF11 gene:
    Search GeneIP for patents involving DCAF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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