DCAF10 Gene
protein-coding GIFtS: 44
GCID: GC09P037800
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|
DDB1 and CUL4 associated factor 10(Previous name: WD repeat domain 32 )
(Previous symbol: WDR32)
| |
Aliases
for DCAF10 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| DDB1 And CUL4 Associated Factor 101 2 | | FLJ232011 | | WDR321 2 3 | | MGC107651 | | WD Repeat Domain 321 2 | | DDB1- And CUL4-Associated Factor 102 | | WD Repeat-Containing Protein 322 3 | | |
Export aliases for DCAF10 gene to outside databasesPrevious GC identifers: GC09P037793 GC09P037753 |
Summaries
for DCAF10 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
|
Genomic Views
for DCAF10 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_008413.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for DCAF10
Other transcription factors
Search SABiosciences Chromatin IP Primers for DCAF10
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF10 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9p13.2 Ensembl cytogenetic band: 9p13.2 HGNC cytogenetic band: 9p13.2DCAF10 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P037800: view genomic region
(about GC identifiers)
Start:
|
37,800,499 bp from pter |
End:
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37,867,666 bp from pter |
Size:
|
67,168 bases |
Orientation:
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plus strand |
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Proteins
for DCAF10 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82 (See
protein sequence)Recommended Name: DDB1- and CUL4-associated factor 10 Size: 559 amino acids; 60582 Da
Subunit: Interacts with DDB1
Sequence caution: Sequence=AAI08687.1; Type=Erroneous initiation; Sequence=BAB15574.1; Type=Erroneous initiation;Sequence=BAC11043.1; Type=Erroneous initiation;
Secondary accessions: A4VCJ5 Q32NE2 Q8N2Q5 Q96ET5 Q9BTQ5 Q9H5P6Alternative splicing: 2 isoforms: Q5QP82-1 Q5QP82-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DCAF10: NX_Q5QP82
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5QP82
DCAF10 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077321.3
ENSEMBL proteins: ENSP00000366953 ENSP00000242323
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0080008 | Cul4-RING ubiquitin ligase complex |
IDA | 16949367 |
DCAF10 for ontologies About GeneDecksing
DCAF10 Antibody Products:
Assay Products for DCAF10: |
Protein
Domains /
Families
for DCAF10 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DCAF10 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5QP82ProtoNet protein and cluster: Q5QP82 UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82Similarity: Belongs to the WD repeat DCAF10 familySimilarity: Contains 7 WD repeats |
Function
for DCAF10 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: DCAF10 (NM_024345) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAF10 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF10 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF10 |
3 GenomeRNAi human phenotypes for DCAF10:
|
Pathways & Interactions
for DCAF10 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCAF10
STRING Interaction
Network Preview (showing 5 interactants - click image to see 21)
5/24 Interacting proteins for DCAF10 (Q5QP823 ENSP000003669534) via UniProtKB, MINT, STRING, and/or I2D (see all 24) About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016567 | protein ubiquitination |
IEA | -- |
DCAF10 for ontologies About GeneDecksing
|
Drugs & Compounds
for DCAF10 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for DCAF10
Search CenterWatch for drugs/clinical trials and news about DCAF10 / DCA10
|
Transcripts
for DCAF10 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DCAF10 gene: NM_024345.3 Unigene Cluster for DCAF10: DDB1 and CUL4 associated factor 10 Hs.118394 [show with all ESTs]Unigene Representative Sequence: NM_0243455 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377724 ENST00000461549 ENST00000483167 ENST00000478453 ENST00000242323(uc010mlz.3 uc004aao.3 uc004aap.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF10 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF10 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DCAF10 (NM_024345) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DCAF10 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF10 |
Additional cDNA sequence: AK023620.1 AK026854.1 AK074532.1 AK309712.1 AK315756.1 BC003520.1 BC011959.1 BC108686.1 BC139834.1 24/27 DOTS entries (see all 27): DT.97770540 DT.97840892 DT.100754517 DT.91724311 DT.121192742 DT.445659 DT.102832930 DT.100891183 DT.121192550 DT.452246 DT.95341413 DT.121643351 DT.121192827 DT.409006 DT.100754519 DT.121192549 DT.121192528 DT.121192653 DT.95168046 DT.121192770 DT.121631911 DT.100754514 DT.121192571 DT.121192787 24/112 AceView cDNA sequences (see all 112): AI368140 CD299973 AI028736 AI338426 AA938632 AI250686 AA468836 AK074532 Z44041 BC011959 NM_024345 BM423996 F09983 BM472469 BC003520 AI085446 BE886956 BU194027 BU684386 AA302573 BM842485 BX430914 AA648750 AW051217
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DCAF10 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for DCAF10
|
Expression
for DCAF10 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DCAF10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGAAACGCC
About this image
See DCAF10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DCAF10
SOURCE GeneReport for Unigene cluster: Hs.118394
SABiosciences Custom PCR Arrays for DCAF10
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAF10
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DCAF10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAF10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAF10 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF10 |
Orthologs
for DCAF10 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DCAF10 gene from 6/20 species (see all 20) About this table
ENSEMBL Gene Tree for DCAF10 (if available)
TreeFam Gene Tree for DCAF10 (if available) |
Paralogs
for DCAF10 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DCAF10 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DCAF10 (37800499 - 37867666 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DCAF10
1 CNV: 2127 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAF10 |
|
Disorders
/ Diseases
for DCAF10 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for DCAF10 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DCAF10 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with DCAF10) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
- Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
- An interaction network of the mammalian COP9 signalos ome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. (PubMed id 19295130)1 Olma M.H....Pintard L. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
- Large-scale proteomics analysis of the human kinome. (PubMed id 19369195)2 Oppermann F.S.... Daub H. (2009)
|
External Searches for DCAF10 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DCAF10 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DCAF10 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DCAF10 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DCAF10 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for DCAF10 gene:
Search GeneIP for patents involving DCAF10
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DCAF10 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for DCAF10 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DCAF10 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DCAF10 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for DCAF10 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF10 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DCAF10 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DCAF10 | | OriGene Custom Protein Services for DCAF10 | | | OriGene Custom Immunoassay Development | | |
| |
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 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DCAF10 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DCAF10 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF10 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DCAF10 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DCAF10 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DCAF10 |
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 |  |  |  | |
| | | | Search Tocris compounds for DCAF10 |
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 | | | DCAF10 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DCAF10 |
|  |  |  | | | | ThermoFisher Antibody for DCAF10 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DCAF10 |
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