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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DCAF10 Gene

protein-coding   GIFtS: 44
GCID: GC09P037800

DDB1 And CUL4 Associated Factor 10

(Previous name: WD repeat domain 32)
(Previous symbol: WDR32)
  Search for DCAF10
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
DDB1 And CUL4 Associated Factor 101 2
WDR321 2 3
WD Repeat Domain 321 2
WD Repeat-Containing Protein 322 3
DDB1- And CUL4-Associated Factor 102

External Ids:    HGNC: 236861   Entrez Gene: 792692   Ensembl: ENSG000001227417   UniProtKB: Q5QP823   

Export aliases for DCAF10 gene to outside databases

Previous GC identifers: GC09P037793 GC09P037753


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DCAF10 Gene: 
DCAF10 (DDB1 and CUL4 associated factor 10) is a protein-coding gene.

UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82
Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NT_008413.18  NC_018920.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for DCAF10
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDCAF10 promoter sequence
   Search SABiosciences Chromatin IP Primers for DCAF10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DCAF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9p13.2   Ensembl cytogenetic band:  9p13.2   HGNC cytogenetic band: 9p13.2

DCAF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DCAF10 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P037800:  view genomic region     (about GC identifiers)

Start:
37,800,499 bp from pter      End:
37,867,666 bp from pter
Size:
67,168 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82 (See protein sequence)
Recommended Name: DDB1- and CUL4-associated factor 10  
Size: 559 amino acids; 60582 Da
Subunit: Interacts with DDB1
Sequence caution: Sequence=AAI08687.1; Type=Erroneous initiation; Sequence=BAB15574.1; Type=Erroneous initiation;
Sequence=BAC11043.1; Type=Erroneous initiation;
Secondary accessions: A4VCJ5 Q32NE2 Q8N2Q5 Q96ET5 Q9BTQ5 Q9H5P6
Alternative splicing: 2 isoforms:  Q5QP82-1   Q5QP82-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DCAF10: NX_Q5QP82

Explore proteomics data for DCAF10 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5QP82

  • DCAF10 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DCAF10 Protein Expression
    REFSEQ proteins: NP_077321.3  
    ENSEMBL proteins: 
     ENSP00000366953   ENSP00000242323  

    Human Recombinant Protein Products for DCAF10: 
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DCAF10 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0080008Cul4-RING ubiquitin ligase complex IDA16949367

    DCAF10 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    DCAF: DDB1 and CUL4 associated factors
    WDR: WD repeat domain containing

    4 InterPro protein domains:
     IPR019775 WD40_repeat_CS
     IPR001680 WD40_repeat
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q5QP82

    ProtoNet protein and cluster: Q5QP82

    UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82
    Similarity: Belongs to the WD repeat DCAF10 family
    Similarity: Contains 7 WD repeats


    DCAF10 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DCA10_HUMAN, Q5QP82
    Function: May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    DCAF10 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DCAF10:
     G0/1 arrest  Increased G1 DNA content  Increased cell size 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DCAF10 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: DCA10_HUMAN, Q5QP82
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DCAF10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/24 Interacting proteins for DCAF10 (Q5QP823 ENSP000003669534) via UniProtKB, MINT, STRING, and/or I2D (see all 24)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLX4Q8IY923, ENSP000002940084I2D: score=2 STRING: ENSP00000294008
    DDB1Q165313, ENSP000003017644I2D: score=1 STRING: ENSP00000301764
    CUL4AQ136193, ENSP000003645894I2D: score=1 STRING: ENSP00000364589
    PAK7Q9P2863I2D: score=5 
    PLK1P533503I2D: score=4 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination IEA--

    DCAF10 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DCAF10 (DCA10)

    Search CenterWatch for drugs/clinical trials and news about DCAF10 / DCA10

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DCAF10 gene: 
    NM_024345.3  

    Unigene Cluster for DCAF10:

    DDB1 and CUL4 associated factor 10
    Hs.118394  [show with all ESTs]
    Unigene Representative Sequence: NM_024345
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377724 ENST00000461549 ENST00000483167 ENST00000478453 ENST00000242323(uc010mlz.3 uc004aao.3 uc004aap.3)

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    8/98 QIAGEN miScript miRNA Assays for microRNAs that regulate DCAF10 (see all 98):
    hsa-miR-124* hsa-miR-579 hsa-miR-607 hsa-miR-300 hsa-miR-15a hsa-miR-4272 hsa-miR-134 hsa-miR-485-3p
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    Additional mRNA sequence: 

    AK023620.1 AK026854.1 AK074532.1 AK309712.1 AK315756.1 BC003520.1 BC011959.1 BC108686.1 
    BC139834.1 

    24/27 DOTS entries (see all 27):

    DT.97770540  DT.97840892  DT.100754517  DT.91724311  DT.121192742  DT.445659  DT.102832930  DT.100891183 
    DT.121192550  DT.452246  DT.95341413  DT.121643351  DT.121192827  DT.409006  DT.100754519  DT.121192549 
    DT.121192528  DT.121192653  DT.95168046  DT.121192770  DT.121631911  DT.100754514  DT.121192571  DT.121192787 

    24/112 AceView cDNA sequences (see all 112):

    AA648750 Z44041 AK074532 AA468836 BU194027 BM472469 AI368140 BC011959 
    BU684386 BE393283 BX430914 CD299973 AI338426 AI028736 AW268422 BE886956 
    AI250686 CA412666 NM_024345 AA938632 AA302573 AI085446 F09983 BC003520 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DCAF10 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d
    SP1:                                                              -                 -     -     -                           
    SP2:                                                  -           -                                                         
    SP3:                                -                             -                                                         
    SP4:                                                  -     -     -                                                         
    SP5:        -                                                                                                               


    ECgene alternative splicing isoforms for DCAF10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DCAF10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAAACGCC
    DCAF10 Expression
    About this image


    See DCAF10 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DCAF10

    SOURCE GeneReport for Unigene cluster: Hs.118394
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DCAF10 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dcaf101 , 5 DDB1 and CUL4 associated factor 101, 5 88.75(n)1
    89.77(a)1
      4 (23.87 cM)5
    2424181  NM_153167.21  NP_694807.21 
     453421015 
    chicken
    (Gallus gallus)
    Aves DCAF101 DDB1 and CUL4 associated factor 10 80.87(n)
    86.71(a)
      426804  XM_424415.3  XP_424415.3 
    lizard
    (Anolis carolinensis)
    Reptilia DCAF106
    Uncharacterized protein
    78(a)
    1 ↔ 1
    GL343201.1(3775683-3790930)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC535572 hypothetical protein MGC53557 80.55(n)    BC041284.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wdr321 WD repeat domain 32 66.8(n)
    75.71(a)
      405882  NM_212946.1  NP_998111.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG15236
    --
    25(a)
    1 ↔ 1
    3R(24643064-24645411)


    ENSEMBL Gene Tree for DCAF10 (if available)
    TreeFam Gene Tree for DCAF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1256 SNPs in DCAF10 are shown (see all 1256)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 9 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs734472761,2
    C,F--37798824(+) TCAGTG/TCATAA 1 -- us2k12Minor allele frequency- T:0.07WA 120
    rs1874838491,2
    --37798868(+) ATCCCA/GCAGGA 1 -- us2k10--------
    rs70492131,2
    C,F,A,H--37799031(+) TCACCG/CTCTAT 1 -- us2k128Minor allele frequency- C:0.18NS EA NA WA CSA 2769
    rs1457638911,2
    --37799209(+) CTGTAC/TGGGCA 1 -- us2k10--------
    rs70491611,2
    C,F,A,H--37799238(+) GCCTCA/CTGGAC 1 -- us2k113Minor allele frequency- C:0.21NS EA WA NA CSA 787
    rs19985861,2
    C,F,H--37799265(-) AGTAAC/ACAGGC 1 -- us2k119Minor allele frequency- A:0.02NS EA NA 1946
    rs1485237711,2
    C--37799313(+) GCTAAA/GTAACA 1 -- us2k10--------
    rs1923333811,2
    --37799333(+) TTCGAC/GAGCCT 1 -- us2k10--------
    rs798634881,2
    C,F--37799365(+) GTAGAA/GTATAC 1 -- us2k11Minor allele frequency- G:0.03WA 118
    rs744084801,2
    F--37799374(+) ACGTGC/TTGGCA 1 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for DCAF10 (37800499 - 37867666 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DCAF10:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1381799CNV Insertion17803354
    nsv831552CNV Gain17160897
    nsv469814CNV Gain16826518

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DCAF10 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with DCAF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2 Jin J.... Walter J.C. (2006)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    4. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    8. Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R....Peters J.M. (2010)
    9. Dynamics of cullin-RING ubiquitin ligase network revea led by systematic quantitative proteomics. (PubMed id 21145461)1 Bennett E.J....Harper J.W. (2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79269 HGNC: 23686 AceView: MGC10765 Ensembl:ENSG00000122741 euGenes: HUgn79269
    ECgene: DCAF10 H-InvDB: DCAF10

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DCAF10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DCAF10 gene:
    Search GeneIP for patents involving DCAF10

    GeneCards and IP:
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