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Aliases for DCAF10 Gene

Aliases for DCAF10 Gene

  • DDB1 And CUL4 Associated Factor 10 2 3 5
  • WD Repeat-Containing Protein 32 3 4
  • WD Repeat Domain 32 2 3
  • WDR32 3 4
  • DDB1- And CUL4-Associated Factor 10 3

External Ids for DCAF10 Gene

Previous HGNC Symbols for DCAF10 Gene

  • WDR32

Previous GeneCards Identifiers for DCAF10 Gene

  • GC09P037793
  • GC09P037753

Summaries for DCAF10 Gene

GeneCards Summary for DCAF10 Gene

DCAF10 (DDB1 And CUL4 Associated Factor 10) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DCAF10 Gene

  • May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DCAF10 Gene

Genomics for DCAF10 Gene

Regulatory Elements for DCAF10 Gene

Enhancers for DCAF10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F037798 0.8 Ensembl ENCODE 0.8 -1.6 -1574 1.1 GATA3 CEBPB IRF1 EBF1 SLC25A51 DCAF10 LOC105376037
GH09F037799 0.6 ENCODE 0.8 +0.6 627 2.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263 LINC01400 TRMT10B SLC25A51 ZBTB5 DCAF10 EXOSC3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DCAF10 on UCSC Golden Path with GeneCards custom track

Promoters for DCAF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001303353 698 2801 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF263

Genomic Location for DCAF10 Gene

Chromosome:
9
Start:
37,800,502 bp from pter
End:
37,867,669 bp from pter
Size:
67,168 bases
Orientation:
Plus strand

Genomic View for DCAF10 Gene

Genes around DCAF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DCAF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DCAF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DCAF10 Gene

Proteins for DCAF10 Gene

  • Protein details for DCAF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5QP82-DCA10_HUMAN
    Recommended name:
    DDB1- and CUL4-associated factor 10
    Protein Accession:
    Q5QP82
    Secondary Accessions:
    • A4VCJ5
    • Q32NE2
    • Q8N2Q5
    • Q96ET5
    • Q9BTQ5
    • Q9H5P6

    Protein attributes for DCAF10 Gene

    Size:
    559 amino acids
    Molecular mass:
    60582 Da
    Quaternary structure:
    • Interacts with DDB1.
    SequenceCaution:
    • Sequence=AAI08687.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15574.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC11043.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DCAF10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DCAF10 Gene

Post-translational modifications for DCAF10 Gene

  • Ubiquitination at Lys 128, Lys 204, Lys 421, Lys 476, and Lys 502
  • Modification sites at PhosphoSitePlus

Other Protein References for DCAF10 Gene

No data available for DME Specific Peptides for DCAF10 Gene

Domains & Families for DCAF10 Gene

Protein Domains for DCAF10 Gene

Suggested Antigen Peptide Sequences for DCAF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5QP82

UniProtKB/Swiss-Prot:

DCA10_HUMAN :
  • Belongs to the WD repeat DCAF10 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat DCAF10 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with DCAF10: view

Function for DCAF10 Gene

Molecular function for DCAF10 Gene

UniProtKB/Swiss-Prot Function:
May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
genes like me logo Genes that share phenotypes with DCAF10: view

Animal Models for DCAF10 Gene

MGI Knock Outs for DCAF10:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DCAF10 Gene

Localization for DCAF10 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DCAF10 Gene COMPARTMENTS Subcellular localization image for DCAF10 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for DCAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0080008 Cul4-RING E3 ubiquitin ligase complex IDA 16949367
genes like me logo Genes that share ontologies with DCAF10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DCAF10 Gene

Pathways & Interactions for DCAF10 Gene

SuperPathways for DCAF10 Gene

No Data Available

UniProtKB/Swiss-Prot Q5QP82-DCA10_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for DCAF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with DCAF10: view

No data available for Pathways by source and SIGNOR curated interactions for DCAF10 Gene

Transcripts for DCAF10 Gene

Unigene Clusters for DCAF10 Gene

DDB1 and CUL4 associated factor 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DCAF10 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e ^ 8 ^ 9a · 9b · 9c · 9d
SP1: - - - -
SP2: - -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - - - -
SP7: - - -
SP8:

Relevant External Links for DCAF10 Gene

GeneLoc Exon Structure for
DCAF10
ECgene alternative splicing isoforms for
DCAF10

Expression for DCAF10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DCAF10 Gene

Protein differential expression in normal tissues from HIPED for DCAF10 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DCAF10 Gene



Protein tissue co-expression partners for DCAF10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DCAF10 Gene:

DCAF10

SOURCE GeneReport for Unigene cluster for DCAF10 Gene:

Hs.118394
genes like me logo Genes that share expression patterns with DCAF10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DCAF10 Gene

Orthologs for DCAF10 Gene

This gene was present in the common ancestor of animals.

Orthologs for DCAF10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DCAF10 34 35
  • 99.82 (n)
dog
(Canis familiaris)
Mammalia DCAF10 34 35
  • 91 (n)
cow
(Bos Taurus)
Mammalia DCAF10 34 35
  • 89.56 (n)
rat
(Rattus norvegicus)
Mammalia Dcaf10 34
  • 89.35 (n)
mouse
(Mus musculus)
Mammalia Dcaf10 34 16 35
  • 88.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DCAF10 35
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DCAF10 35
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DCAF10 34 35
  • 83.1 (n)
lizard
(Anolis carolinensis)
Reptilia DCAF10 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dcaf10 34
  • 77.55 (n)
Str.16568 34
African clawed frog
(Xenopus laevis)
Amphibia MGC53557 34
zebrafish
(Danio rerio)
Actinopterygii wdr32 34 35
  • 70.2 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000200 34
  • 50.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG1523 35
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for DCAF10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DCAF10 Gene

ENSEMBL:
Gene Tree for DCAF10 (if available)
TreeFam:
Gene Tree for DCAF10 (if available)

Paralogs for DCAF10 Gene

No data available for Paralogs for DCAF10 Gene

Variants for DCAF10 Gene

Sequence variations from dbSNP and Humsavar for DCAF10 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10114515 -- 37,837,520(+) TTACT(A/C)AGCTT intron-variant
rs10115457 -- 37,861,797(+) TGTCA(A/C)GTTCC nc-transcript-variant, utr-variant-3-prime
rs10115555 -- 37,852,965(+) atata(A/T)aaatt intron-variant
rs10116344 -- 37,832,789(+) CAGGA(C/T)TAAGG intron-variant
rs10116821 -- 37,808,709(+) TATAT(A/T)TATAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DCAF10 Gene

Variant ID Type Subtype PubMed ID
esv1381799 CNV insertion 17803354
nsv1125318 OTHER inversion 24896259
nsv469814 CNV gain 16826518
nsv831552 CNV gain 17160897

Variation tolerance for DCAF10 Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DCAF10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DCAF10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DCAF10 Gene

Disorders for DCAF10 Gene

Relevant External Links for DCAF10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DCAF10

No disorders were found for DCAF10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DCAF10 Gene

Publications for DCAF10 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 2 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for DCAF10 Gene

Sources for DCAF10 Gene

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