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Aliases for DBX2 Gene

Aliases for DBX2 Gene

  • Developing Brain Homeobox 2 2 3 5
  • Developing Brain Homeobox Protein 2 4

External Ids for DBX2 Gene

Previous GeneCards Identifiers for DBX2 Gene

  • GC12M043697
  • GC12M045408
  • GC12M042436

Summaries for DBX2 Gene

GeneCards Summary for DBX2 Gene

DBX2 (Developing Brain Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is DBX1.

Gene Wiki entry for DBX2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBX2 Gene

Genomics for DBX2 Gene

Regulatory Elements for DBX2 Gene

Enhancers for DBX2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DBX2 on UCSC Golden Path with GeneCards custom track

Promoters for DBX2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DBX2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DBX2 Gene

Chromosome:
12
Start:
45,014,672 bp from pter
End:
45,051,099 bp from pter
Size:
36,428 bases
Orientation:
Minus strand

Genomic View for DBX2 Gene

Genes around DBX2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBX2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBX2 Gene

Proteins for DBX2 Gene

  • Protein details for DBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZNG2-DBX2_HUMAN
    Recommended name:
    Homeobox protein DBX2
    Protein Accession:
    Q6ZNG2

    Protein attributes for DBX2 Gene

    Size:
    339 amino acids
    Molecular mass:
    36555 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DBX2 Gene

Post-translational modifications for DBX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DBX2 Gene

Domains & Families for DBX2 Gene

Gene Families for DBX2 Gene

Suggested Antigen Peptide Sequences for DBX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZNG2

UniProtKB/Swiss-Prot:

DBX2_HUMAN :
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the H2.0 homeobox family.
Domain:
  • Contains 1 homeobox DNA-binding domain.
Family:
  • Belongs to the H2.0 homeobox family.
genes like me logo Genes that share domains with DBX2: view

Function for DBX2 Gene

Gene Ontology (GO) - Molecular Function for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DBX2: view
genes like me logo Genes that share phenotypes with DBX2: view

Animal Model Products

CRISPR Products

miRNA for DBX2 Gene

miRTarBase miRNAs that target DBX2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DBX2 Gene

Localization for DBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBX2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBX2 Gene COMPARTMENTS Subcellular localization image for DBX2 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DBX2: view

Pathways & Interactions for DBX2 Gene

SuperPathways for DBX2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DBX2: view

No data available for Pathways by source and SIGNOR curated interactions for DBX2 Gene

Drugs & Compounds for DBX2 Gene

No Compound Related Data Available

Transcripts for DBX2 Gene

mRNA/cDNA for DBX2 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DBX2 Gene

Developing brain homeobox 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBX2 Gene

No ASD Table

Relevant External Links for DBX2 Gene

GeneLoc Exon Structure for
DBX2
ECgene alternative splicing isoforms for
DBX2

Expression for DBX2 Gene

mRNA expression in normal human tissues for DBX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBX2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.0), Brain - Substantia nigra (x5.1), Brain - Hypothalamus (x4.4), and Brain - Amygdala (x4.2).

Protein differential expression in normal tissues from HIPED for DBX2 Gene

This gene is overexpressed in Breast (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBX2 Gene



Protein tissue co-expression partners for DBX2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DBX2 Gene:

DBX2

SOURCE GeneReport for Unigene cluster for DBX2 Gene:

Hs.302764
genes like me logo Genes that share expression patterns with DBX2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DBX2 Gene

Orthologs for DBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DBX2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DBX2 34
  • 86.88 (n)
  • 85.21 (a)
DBX2 35
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbx2 34
  • 79.19 (n)
  • 76.75 (a)
Dbx2 16
Dbx2 35
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DBX2 34
  • 98.82 (n)
  • 98.82 (a)
DBX2 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbx2 34
  • 79.51 (n)
  • 77.39 (a)
dog
(Canis familiaris)
Mammalia DBX2 35
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DBX2 35
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBX2 34
  • 77.74 (n)
  • 78.18 (a)
DBX2 35
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBX2 35
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbx2 34
  • 63.73 (n)
  • 61.11 (a)
zebrafish
(Danio rerio)
Actinopterygii dbx2 35
  • 43 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Dbx 35
  • 13 (a)
OneToOne
Species where no ortholog for DBX2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBX2 Gene

ENSEMBL:
Gene Tree for DBX2 (if available)
TreeFam:
Gene Tree for DBX2 (if available)

Paralogs for DBX2 Gene

Paralogs for DBX2 Gene

(7) SIMAP similar genes for DBX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DBX2: view

Variants for DBX2 Gene

Sequence variations from dbSNP and Humsavar for DBX2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2731038 - 45,023,883(-) AGAGC(A/C/G/T)TGCTG reference, missense
rs1826711 -- 45,020,191(-) TAGAA(C/T)AGAGA intron-variant
rs7309286 -- 45,050,984(+) CCGGG(C/G)GCCCC utr-variant-5-prime
rs2021513 -- 45,031,227(-) CTCTC(A/T)CACAC intron-variant
rs7315817 -- 45,048,326(+) TTGTG(G/T)TCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBX2 Gene

Variant ID Type Subtype PubMed ID
esv1002864 CNV insertion 20482838
esv1534356 CNV insertion 17803354
esv2404363 CNV deletion 18987734
esv2745836 CNV deletion 23290073
esv2745837 CNV deletion 23290073
esv2745838 CNV deletion 23290073
esv2745839 CNV deletion 23290073
esv2745840 CNV deletion 23290073
esv3580254 CNV loss 25503493
nsv1051285 CNV loss 25217958
nsv1142807 CNV tandem duplication 24896259

Variation tolerance for DBX2 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.84; 47.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBX2 Gene

Human Gene Mutation Database (HGMD)
DBX2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBX2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBX2 Gene

Disorders for DBX2 Gene

Relevant External Links for DBX2

Genetic Association Database (GAD)
DBX2
Human Genome Epidemiology (HuGE) Navigator
DBX2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBX2

No disorders were found for DBX2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBX2 Gene

Publications for DBX2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  2. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PMID: 11239429) Pierani A. … Jessell T.M. (Neuron 2001) 2 3 65
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 65

Products for DBX2 Gene

Sources for DBX2 Gene

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