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Aliases for DBX2 Gene

Aliases for DBX2 Gene

  • Developing Brain Homeobox 2 2 3
  • Developing Brain Homeobox Protein 2 4

External Ids for DBX2 Gene

Previous GeneCards Identifiers for DBX2 Gene

  • GC12M043697
  • GC12M045408
  • GC12M042436

Summaries for DBX2 Gene

GeneCards Summary for DBX2 Gene

DBX2 (Developing Brain Homeobox 2) is a Protein Coding gene. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region sequence-specific DNA binding. An important paralog of this gene is HHEX.

Gene Wiki entry for DBX2 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBX2 Gene

Genomics for DBX2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DBX2 Gene

45,014,672 bp from pter
45,051,099 bp from pter
36,428 bases
Minus strand

Genomic View for DBX2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DBX2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBX2 Gene

Proteins for DBX2 Gene

  • Protein details for DBX2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein DBX2
    Protein Accession:
    Secondary Accessions:

    Protein attributes for DBX2 Gene

    339 amino acids
    Molecular mass:
    36555 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DBX2 Gene

Proteomics data for DBX2 Gene at MOPED

Post-translational modifications for DBX2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBX2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DBX2 Gene

Domains for DBX2 Gene

Gene Families for DBX2 Gene

  • NKL :Homeoboxes / ANTP class : NKL subclass

Suggested Antigen Peptide Sequences for DBX2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q6ZNG2
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the H2.0 homeobox family.
genes like me logo Genes that share domains with DBX2: view

Function for DBX2 Gene

Gene Ontology (GO) - Molecular Function for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with DBX2: view

Phenotypes for DBX2 Gene

GenomeRNAi human phenotypes for DBX2:
genes like me logo Genes that share phenotypes with DBX2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DBX2 Gene

Localization for DBX2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBX2 Gene

Subcellular locations from

Jensen Localization Image for DBX2 Gene COMPARTMENTS Subcellular localization image for DBX2 gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DBX2: view

Pathways for DBX2 Gene

SuperPathways for DBX2 Gene

No Data Available

Interacting Proteins for DBX2 Gene

Gene Ontology (GO) - Biological Process for DBX2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with DBX2: view

No data available for Pathways by source for DBX2 Gene

Transcripts for DBX2 Gene

mRNA/cDNA for DBX2 Gene

(3) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DBX2 Gene

Developing brain homeobox 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DBX2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DBX2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBX2 Gene

No ASD Table

Relevant External Links for DBX2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DBX2 Gene

mRNA expression in normal human tissues for DBX2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBX2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.0), Brain - Substantia nigra (5.1), Brain - Hypothalamus (4.4), and Brain - Amygdala (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DBX2 Gene

SOURCE GeneReport for Unigene cluster for DBX2 Gene Hs.302764

genes like me logo Genes that share expressions with DBX2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DBX2 Gene

Orthologs for DBX2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DBX2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DBX2 35
  • 98.82 (n)
  • 98.82 (a)
DBX2 36
  • 99 (a)
(Bos Taurus)
Mammalia DBX2 35
  • 86.88 (n)
  • 85.21 (a)
DBX2 36
  • 85 (a)
(Canis familiaris)
Mammalia DBX2 36
  • 91 (a)
(Mus musculus)
Mammalia Dbx2 35
  • 79.19 (n)
  • 76.75 (a)
Dbx2 16
Dbx2 36
  • 64 (a)
(Monodelphis domestica)
Mammalia DBX2 36
  • 68 (a)
(Rattus norvegicus)
Mammalia Dbx2 35
  • 79.51 (n)
  • 77.39 (a)
(Gallus gallus)
Aves DBX2 35
  • 77.74 (n)
  • 78.18 (a)
DBX2 36
  • 65 (a)
(Anolis carolinensis)
Reptilia DBX2 36
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dbx2 35
  • 63.73 (n)
  • 61.11 (a)
(Danio rerio)
Actinopterygii dbx2 36
  • 43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dbx 36
  • 13 (a)
Species with no ortholog for DBX2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBX2 Gene

Gene Tree for DBX2 (if available)
Gene Tree for DBX2 (if available)

Paralogs for DBX2 Gene

Paralogs for DBX2 Gene

Selected SIMAP similar genes for DBX2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DBX2: view

Variants for DBX2 Gene

Sequence variations from dbSNP and Humsavar for DBX2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs978696 -- 45,025,243(-) AGGAC(C/T)TCCTA intron-variant
rs1004593 -- 45,027,698(+) ACACA(A/G)AATTG intron-variant
rs1224442 -- 45,016,292(-) GGGGC(C/T)GTCTG synonymous-codon, reference
rs1224443 -- 45,015,676(-) AATGA(A/G)CCTAA utr-variant-3-prime
rs1224444 -- 45,014,925(-) ACTCC(A/G)CTAGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DBX2 Gene

Variant ID Type Subtype PubMed ID
esv2745836 CNV Deletion 23290073
esv2745837 CNV Deletion 23290073
esv2745838 CNV Deletion 23290073
esv270692 CNV Insertion 20981092
esv273643 CNV Insertion 20981092
esv1002864 CNV Insertion 20482838
esv1534356 CNV Insertion 17803354
esv2745839 CNV Deletion 23290073
esv2404363 CNV Deletion 18987734
esv2745840 CNV Deletion 23290073

Relevant External Links for DBX2 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBX2 Gene

Disorders for DBX2 Gene

Relevant External Links for DBX2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DBX2: view

No data available for UniProtKB/Swiss-Prot for DBX2 Gene

Publications for DBX2 Gene

  1. Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PMID: 11239429) Pierani A. … Jessell T.M. (Neuron 2001) 2 3
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4

Products for DBX2 Gene

Sources for DBX2 Gene

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