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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DBX2 Gene

protein-coding GIFtS: 43
GCID: GC12M045408

developing brain homeobox 2

Search for DBX2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Developing Brain Homeobox 2¹ ²
Developing Brain Homeobox Protein 2² ³
FLJ16139¹
Homeobox Protein DBX2²

External Ids:	HGNC: 33186¹	Entrez Gene: 440097²	Ensembl: ENSG00000185610⁷	UniProtKB: Q6ZNG2³

Export aliases for DBX2 gene to outside databases

Previous GC identifers: GC12M043697 GC12M042436

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for DBX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DBX2 gene promoter:
POU2F2 (Oct-2.1) Oct-B1 oct-B3 oct-B2 POU2F2 YY1 PPAR-gamma1 POU2F1 POU2F1a PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DBX2 promoter sequence

Search SABiosciences Chromatin IP Primers for DBX2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DBX2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12 Ensembl cytogenetic band: 12q12 HGNC cytogenetic band: 12q12

DBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBX2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M045408: view genomic region (about GC identifiers)

Start:	45,408,455 bp from pter	End:	45,444,882 bp from pter
Size:	36,428 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DBX2_HUMAN, Q6ZNG2 (See protein sequence)

Recommended Name: Homeobox protein DBX2

Size: 339 amino acids; 36555 Da

Subcellular location: Nucleus (By similarity)

Explore the universe of human proteins at neXtProt for DBX2: NX_Q6ZNG2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6ZNG2

DBX2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001004329.2

ENSEMBL proteins:

ENSP00000331470

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

DBX2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DBX2 for domains About GeneDecksing

5 InterPro domains/families:

IPR020479 Homeobox_metazoa

IPR000047 HTH_motif

IPR017970 Homeobox_CS

IPR001356 Homeodomain

IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry Q6ZNG2

ProtoNet protein and cluster: Q6ZNG2

1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: DBX2_HUMAN, Q6ZNG2

Similarity: Belongs to the H2.0 homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000976	transcription regulatory region sequence-specific DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--

DBX2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DBX2:

Decreased POU5F1-GFP protein e

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DBX2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DBX2
Search CenterWatch for drugs/clinical trials and news about DBX2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for DBX2 gene:

NM_001004329.2

Unigene Cluster for DBX2:

Developing brain homeobox 2

Hs.302764 [show with all ESTs]

Unigene Representative Sequence: AK131230

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000332700(uc001rok.1)

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Additional cDNA sequence: AK131230.1

1 DOTS entry:

DT.40192261

3 AceView cDNA sequences:

AK131230 BF939451 NM_001004329

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DBX2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTTTTACT

About this image

DBX2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

V0 Neural Progenitor Domain

V0 Neural Progenitor Cells

Selective marker (cell-identifying gene)

Motor Neurons

Spinal Cord

V1 Neural Progenitor Domain

V1 Neural Progenitor Cells

Motor Neurons

Spinal Cord

V2 Neural Progenitor Domain

V2 Neural Progenitor Cells

Motor Neurons

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DBX2 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.302764

SABiosciences Custom PCR Arrays for DBX2

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DBX2 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DBX2¹	developing brain homeobox 2	78.14(n) 78.69(a)		417801 XM_416044.3 XP_416044.3
lizard (Anolis carolinensis)	Reptilia	DBX2⁶	--	84(a)	1 ↔ 1	5(53952563-53955723)
zebrafish (Danio rerio)	Actinopterygii	dbx2⁶ dbx1b⁶	developing brain homeobox 1b	41(a) 31(a)	1 ↔ 1 possible ortholog	Zv9_scaffold3556(4519-13947) 25(14768244-14771154)
fruit fly (Drosophila melanogaster)	Insecta	Dbx⁶	Dbx	11(a)	1 → many	3L(1921307-1933603)

ENSEMBL Gene Tree for DBX2 (if available)
TreeFam Gene Tree for DBX2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DBX2 gene

HLX² DBX1² HHEX²

9 SIMAP similar genes for DBX2 using alignment to 1 protein entry: DBX2_HUMAN:

HMX2 HOXB1 HOXC13 MEOX1 DLX3 HLX

HOXA4 DUX2 DBX1

DBX2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1224446^1,2	C,F,O,A,H	--	45408068(-)	`AGAAGA/CTTTAC`	1	--	ds500¹		18		MN EA NA WA CSA	779
rs71459292^1,2	C,F	--	45408187(+)	`AGATTC/ACAAGA`	1	--	ds500¹		4		NA	126
rs142062905^1,2		--	45408225(+)	`TCCCAC/TTTATT`	1	--	ds500¹		0	--	--	--	--
rs150102957^1,2		--	45408293(+)	`GGTAAA/CAGGAA`	1	--	ds500¹		0	--	--	--	--
rs58216694^1,2	C	--	45408316(+)	`TTACCG/ATCTAC`	1	--	ds500¹		1		WA	2
rs74392113^1,2	F	--	45408365(+)	`CCACCC/GTAAAT`	1	--	ds500¹		1		WA	118
rs187311682^1,2		--	45408396(+)	`CATAGA/GAAGTA`	1	--	ds500¹		0	--	--	--	--
rs191845352^1,2		--	45408482(+)	`TTTTAA/GCTTTT`	1	--	ds500¹		0	--	--	--	--
rs73275560^1,2	C	--	45408511(+)	`CCATTC/GCCCAC`	1	--	ds500¹		2		WA	120
rs1224445^1,2	C,F,O,A,H	--	45408606(-)	`TACGAG/ATAGAA`	1	--	ut3¹		29		MN NS EA NA WA CSA	2857

HapMap Linkage Disequilibrium report for DBX2 (45408455 - 45444882 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DBX2
1 Indel: 45054

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DBX2 for disorders About MalaCards

DBX2 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: DBX2 (1 document)

Export disorders for DBX2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DBX2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with DBX2)

Utopia: connect your pdf to the dynamic
world of online information

Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PubMed id 11239429)^{1, 3} Pierani A....Jessell T.M. (2001)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 440097	HGNC: 33186	AceView: FLJ16139	Ensembl:ENSG00000185610	euGenes: HUgn440097
ECgene: DBX2	H-InvDB: DBX2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DBX2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DBX2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DBX2 gene:
Search GeneIP for patents involving DBX2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBX2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DBX2

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DBX2 gene at Home site.

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DBX2 Gene

developing brain homeobox 2

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DBX2 Gene

developing brain homeobox 2

Aliasesfor DBX2 gene

Summariesfor DBX2 gene

Genomic Viewsfor DBX2 gene

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Protein Domains /Familiesfor DBX2 gene

Functionfor DBX2 gene

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Genome Databases showing DBX2 gene

Other Databases showing DBX2 gene

Specialized Databases showing DBX2 gene

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for DBX2 gene

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for DBX2 gene

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for DBX2 gene

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for DBX2 gene

Protein Domains /
Families
for DBX2 gene

Function
for DBX2 gene

Pathways & Interactions
for DBX2 gene

Drugs & Compounds
for DBX2 gene

Transcripts
for DBX2 gene

Expression
for DBX2 gene

Orthologs
for DBX2 gene

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for DBX2 gene

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for DBX2 gene

Disorders / Diseases
for DBX2 gene

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for DBX2 gene

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for DBX2 gene

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for DBX2 gene