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DBX2 Gene

protein-coding GIFtS: 41

GC12M043697

developing brain homeobox 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ16139 ^¹, ²

Descriptions
Developing brain homeobox protein 2 ^³
developing brain homeobox 2 ^²

External Ids
HGNC: 33186¹
Entrez Gene: 440097²
UniProtKB: Q6ZNG2³
Ensembl: ENSG00000185610⁷

Search outside databases for aliases for DBX2 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DBX2 gene

Entrez Gene cytogenetic band: 12q12 Ensembl cytogenetic band: 12q12 HGNC cytogenetic band: 12q12

DBX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M043697: (about GC identifiers)

Start:	43,694,806 bp from pter
End:	43,731,149 bp from pter
Size:	36,344 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000012.10 NT_029419.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DBX2_HUMAN, Q6ZNG2 (See protein sequence)

Recommended Name: Homeobox protein DBX2

Size: 339 amino acids; 36523 Da

Subcellular location: Nucleus (By similarity)

REFSEQ proteins: NP_001004329.2

ENSEMBL proteins:

ENSP00000331470

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (dbx2)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for DBX2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DBX2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (dbx2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for DBX2

Assays for DBX2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q6ZNG2

ProtoNet protein and cluster: Q6ZNG2

1 Blocks protein family: IPB000047 Lambda and other repressor helix-turn-helix signature

UniProtKB/Swiss-Prot: DBX2_HUMAN, Q6ZNG2

Similarity: Belongs to the H2.0 homeobox family

Similarity: Contains 1 homeobox DNA-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DBX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DBX2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001004329

Applied Biosystems Silencer® siRNAs for DBX2

Sigma-Aldrich siRNA for DBX2

Sigma-Aldrich shRNA for DBX2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001004329
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001004329
untagged cDNA clone in CMV expression vector: NM_001004329

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001004329

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DBX2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DBX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DBX2)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001004329

Sigma-Aldrich siRNA for DBX2

Sigma-Aldrich shRNA for DBX2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001004329

REFSEQ mRNAs for DBX2 gene:

NM_001004329.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001004329

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001004329
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001004329
                                 untagged cDNA clone in CMV expression vector: NM_001004329

Additional cDNA sequence: AK131230.1

1 DOTS entry:

DT.40192261

3 AceView cDNA sequences:

BF939451 AK131230 NM_001004329

highest scoring ESTs for DBX2:

AK131230 AA639179 BF939451 BX100473 DA142616 DB174848 DB482771 H16300 NM_001004329 DB301295

Unigene Cluster for DBX2:

Developing brain homeobox 2

Hs.302764 [show with all ESTs]

Unigene Representative Sequence: AK131230

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000332700

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DBX2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DBX2

¹ Data from GNF BioGPS
About these images

About these images

CGAP SAGE TAG: ATCTTTTACT

SOURCE GeneReport for Unigene cluster: Hs.302764

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for DBX2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	DBX2¹	--	developing brain homeobox 2	98.82(n) 98.82(a)	466963 XM_522363.2 XP_522363.2
cow (Bos taurus)	DBX2¹	--	developing brain homeobox 2	87.67(n) 86.09(a)	510669 NM_001075461.1 NP_001068929.1
rat (Rattus norvegicus)	Dbx2¹	--	developing brain homeobox 2	79.51(n) 77.39(a)	541457 XM_001053826.1 XP_001053826.1
mouse (Mus musculus)	Dbx2^{1, 5}	15 (71.10 cM)⁵	developing brain homeobox 2^{1, 5}	79.09(n)¹ 76.75(a)¹	223843¹ NM_207533.2¹ NP_997416.2¹ AI846217⁵ AK034882⁵ (see all 9)
chicken (Gallus gallus)	DBX2¹	--	developing brain homeobox 2	78.14(n) 78.69(a)	417801 XM_416044.2 XP_416044.2

About this table Species with no ortholog for DBX2

ENSEMBL Gene Tree for DBX2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DBX2 gene

DBX1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/257 NCBI SNPs in DBX2 are shown (see all 257 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 104)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1224445^1,2	A,C,F,H,O	43694873(-)	`TACGAG/ATAGAA`	1	--	ut3¹		10		MN EU EA WA NA	924
	rs1224446^1,2	A,C,F,O	43694335(-)	`AGAAGA/CTTTAC`	1	--	ng5¹		5		MN EA NA	400
	rs2731038^1,2	A,C,F,H	43703933(-)	`AGAGCG/ATGCTG`	1	V/M	mis¹		8		EU EA WA	836
	rs1224444^1,2	A,C,F,O	43694975(-)	`ACTCCG/ACTAGA`	1	--	ut3¹		6		MN NA	508
	rs4140696^1,2	A,C,F	43731523(-)	`ACTGCC/TTGGGC`	1	--	ng3¹		2		NA	182
	rs17600173^1,2	F,H	43695116(+)	`TTGTTT/GCATTT`	1	--	ut3¹		7		NA EU EA WA	562
--	rs6582528^1,2	A,C	43733095(+)	`agttgA/Gttttc`	1	--	ng3¹		0	--	--	--	--
	rs1224443^1,2	F,H	43695726(-)	`AATGAA/GCCTAA`	1	--	ut3¹		4		EU EA WA	410
	rs35799097^1,2	F	43731992(+)	`AATACG/ATTTTG`	1	--	ng3¹		2		NA	182
	rs1224442^1,2	C,F,H	43696342(-)	`GGGGCC/TGTCTG`	1	A/A	syn¹		5		MN EU EA WA	602

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HapMap Linkage Disequilibrium images for DBX2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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2 PubMed articles for DBX2 gene:

Control of interneuron fate in the developing spinal cord by the progenitor homeodomain protein Dbx1. (PubMed id 11239429)^{2, 3} Pierani A....Jessell T.M. (2001)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)⁴ Ota T....Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 440097	HGNC: 33186	AceView: FLJ16139	Ensembl:ENSG00000185610	euGenes: HUgn440097
ECgene: DBX2	H-InvDB: DBX2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for DBX2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DBX2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DBX2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DBX2		Antibodies for DBX2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DBX2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for DBX2

Search Tocris compounds for DBX2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for DBX2

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DBX2 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for DBX2

Summaries
for DBX2

Genomic Location
for DBX2

Proteins
for DBX2

Protein Domains/
Families
for DBX2

Gene Function
for DBX2

Pathways & Interactions
for DBX2

Drugs & Compounds
for DBX2

Transcripts
for DBX2

Expression
for DBX2

Orthologs
for DBX2

Paralogs
for DBX2

SNPs/Variants
for DBX2

Disorders & Mutations
for DBX2

Medical News
for DBX2

Publications
for DBX2

Search for DBX2

Genome Databases showing DBX2

Other Databases showing DBX2

Specialized Databases showing DBX2

Licensable Technologies
for DBX2

Services
for DBX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DBX2 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor DBX2

Summariesfor DBX2

Genomic Locationfor DBX2

Proteinsfor DBX2

Protein Domains/Familiesfor DBX2

Gene Functionfor DBX2

Pathways & Interactionsfor DBX2

Drugs & Compoundsfor DBX2

Transcriptsfor DBX2

Expression for DBX2

Orthologsfor DBX2

Paralogsfor DBX2

SNPs/Variantsfor DBX2

Disorders & Mutationsfor DBX2

Medical Newsfor DBX2

Publicationsfor DBX2

Search for DBX2

Genome Databases showing DBX2

Other Databases showing DBX2

Specialized Databases showing DBX2

Licensable Technologiesfor DBX2

Servicesfor DBX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DBX2

Summaries
for DBX2

Genomic Location
for DBX2

Proteins
for DBX2

Protein Domains/
Families
for DBX2

Gene Function
for DBX2

Pathways & Interactions
for DBX2

Drugs & Compounds
for DBX2

Transcripts
for DBX2

Expression
for DBX2

Orthologs
for DBX2

Paralogs
for DBX2

SNPs/Variants
for DBX2

Disorders & Mutations
for DBX2

Medical News
for DBX2

Publications
for DBX2

Licensable Technologies
for DBX2

Services
for DBX2