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DBX1 Gene

protein-coding   GIFtS: 37

GC11M020135
developing brain homeobox 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for DBX1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Descriptions
Developing brain homeobox protein 1 3
developing brain homeobox 1 2
External Ids
HGNC: 331851
Entrez Gene: 1202372
UniProtKB: A6NMT03
Ensembl: ENSG000001098517
Search outside databases for aliases for DBX1 gene

Summaries
for DBX1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DBX1_HUMAN, A6NMT0
Function: Could have a role in patterning the central nervous system during embryogenesis. Has a
key role in regulating the distinct phenotypic features that distinguish two major classes of
ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile,
neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons,
features that differentiate them from an adjacent set of V1 neurons (By similarity)

Genomic Location
for DBX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DBX1 gene  

Entrez Gene cytogenetic band: 11p15.1   Ensembl cytogenetic band:  11p15.1   HGNC cytogenetic band: 11p15.1

DBX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M020135:     (about GC identifiers)

Start:
 20,134,336 bp from pter
End:
 20,138,446 bp from pter
Size:
 4,111 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000011.8  NT_009237.17  

Proteins
for DBX1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: DBX1_HUMAN, A6NMT0 (See protein sequence)
Recommended Name: Homeobox protein DBX1  
Size: 343 amino acids; 37283 Da
Subcellular location: Nucleus (By similarity)

REFSEQ proteins: NP_001025036.1  

ENSEMBL proteins: 
ENSP00000227256 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (dbx1)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
About this table

Antibodies for DBX1: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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Antibodies from Abcam (dbx1), each with their AbpromiseSM
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Search Novus for antibodies for DBX1

Assays for DBX1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for DBX1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR000047 HTH_lambrepressr
 IPR001356 Homeobox
 IPR017970 Homeobox_CS
 IPR012287 Homeodomain-rel


   GeneDecks  DBX1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry A6NMT0

ProtoNet protein and cluster: A6NMT0

UniProtKB/Swiss-Prot: DBX1_HUMAN, A6NMT0
Similarity: Belongs to the H2.0 homeobox family
Similarity: Contains 1 homeobox DNA-binding domain

Gene Function
for DBX1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (DBX1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001029865

              Applied Biosystems Silencer® siRNAs for DBX1

              Browse siRNA at Sigma-Aldrich  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001029865
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001029865
                                 untagged cDNA clone in CMV expression vector: NM_001029865 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001029865

UniProtKB/Swiss-Prot: DBX1_HUMAN, A6NMT0
Function: Could have a role in patterning the central nervous system during embryogenesis. Has a
key role in regulating the distinct phenotypic features that distinguish two major classes of
ventral interneurons, V0 and V1 neurons. Regulates the transcription factor profile,
neurotransmitter phenotype, intraspinal migratory path and axonal trajectory of V0 neurons,
features that differentiate them from an adjacent set of V1 neurons (By similarity)

3 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Dbx1):

lethality-prenatal/perinatalnervous systemno phenotypic analysis

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity IEA--
GO:0043565 sequence-specific DNA binding IEA--
About this table

Pathways & Interactions
for DBX1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



1 Interacting protein for DBX1 (ENSP000002272563) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
PAX6ENSP000003684243STRING (score=.712)
About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0007275 multicellular organismal development IEA--
About this table

Drugs & Compounds
for DBX1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DBX1

Transcripts
for DBX1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (DBX1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001029865

              Browse siRNA at Sigma-Aldrich  
                     Browse shRNA at Sigma-Aldrich  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001029865  

REFSEQ mRNAs for DBX1 gene: 

NM_001029865.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001029865  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001029865
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001029865
                                 untagged cDNA clone in CMV expression vector: NM_001029865 

1 DOTS entry:

DT.120695908 

highest scoring ESTs for DBX1:

NM_001029865 DY655769 DY655770 

Unigene Cluster for DBX1:

Developing brain homeobox 1
Hs.558604  [show with all ESTs]
Unigene Representative Sequence: NM_001029865


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000227256  

Expression
for DBX1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DBX1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for DBX1

1Data from GNF BioGPS
    About these images

About these images

CGAP SAGE TAG: AAATGGCGGA

SOURCE GeneReport for Unigene cluster: Hs.558604

Orthologs
for DBX1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for DBX1 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LOC4854121   -- similar to developing brain homeobox 1 (predicted) 82.8(n)
81.23(a)		 485412  XM_542531.2  XP_542531.2 
cow
(Bos taurus)		 DBX11   -- developing brain homeobox 1 87.15(n)
88.56(a)		 517514  XM_595686.3  XP_595686.2 
rat
(Rattus norvegicus)		 Dbx11   -- developing brain homeobox 1 84.18(n)
91.04(a)		 292934  NM_001009644.1  NP_001009644.1 
mouse
(Mus musculus)		 Dbx11, 5 7 (22.80 cM)5
 developing brain homeobox 11, 5 84.38(n)1
89.85(a)1		 131721  NM_001005232.11  NP_001005232.11 
 AI4260265  AI6615355  (see all 9)
zebrafish
(Danio rerio)		 AF030285.12   --   -- 72.09(n) 30416  AF030285.1 
About this table        Species with no ortholog for DBX1

ENSEMBL Gene Tree for DBX1

Paralogs
for DBX1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for DBX1 gene
DBX22  

SNPs/Variants
for DBX1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/37 NCBI SNPs in DBX1 are shown (see all 37 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 27)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs108332581,2
A,C,F20139355(+) TAAAAC/GGAGTC 1 -- ng314Minor allele frequency- N:0.01EA NA 216
rs8314631,2
C,F,H20134806(+) TCGGGC/ATGTGT 1 S/A mis1 ese311Minor allele frequency- A:0.01NA EA MN EU WA 864
rs110254171,2
C,F20140411(+) GGAGTT/GAATTG 1 -- ng313Minor allele frequency- G:0.46NA 140
--
rs107324721,2
C,F20139420(+) GGGCTC/GTCCGC 1 -- ng31 tfbs33Minor allele frequency- G:0.12NA 142
rs172324301,2
F20138833(+) TATCGA/GCCGCC 1 -- ng313Minor allele frequency- G:0.02NA 142
rs8314621,2
C,F,H20134786(+) TCGGGT/AGCAGG 1 A/A syn1 ese38Minor allele frequency- A:0.02MN EU EA WA NA 740
rs8314641,2
C,F,H20135293(+) GCCCCG/TCCGAG 1 R/R syn1 ese35Minor allele frequency- T:0.12MN EU EA WA 604
rs8314651,2
C,F,H,O20135461(-) GAGCGC/TTTTAA 1 -- int15Minor allele frequency- T:0.13MN EU EA WA 602
rs107418221,2
C,F,H20137180(+) ATGTTG/ATACGC 1 -- int115Minor allele frequency- A:0.11EU EA WA NA 1398
--
rs110254161,2
A,C20137809(+) GCGTGC/TGCTCA 1 -- int10--------
About this table

HapMap Linkage Disequilibrium images for DBX1 (up to first 250kb)

Disorders & Mutations
for DBX1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for DBX1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for DBX1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

2 PubMed articles for DBX1 gene:

Search for DBX1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing DBX1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 120237 HGNC: 33185 Ensembl:ENSG00000109851 euGenes: HUgn120237 ECgene: DBX1
H-InvDB: DBX1

Other Databases showing DBX1

(According to HUGE)
About This Section

   --

Specialized Databases showing DBX1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for DBX1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for DBX1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for DBX1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for DBX1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


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 Search Novus for antibodies for DBX1

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