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DBT Gene

protein-coding GIFtS: 66

GC01M100371

dihydrolipoamide branched chain transacylase E2
(Previous name: dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
BCATE2 ^², ³, ⁵
E2 ^², ³
E2B ^²
EC 2.3.1.168 ^³
MGC9061 ^²
OTTHUMP00000012596 ^²

Descriptions
BCKAD E2 subunit ^², ³
Dihydrolipoamide branched chain transacylase ^², ³
Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase ^², ³
E2 component of branched chain alpha-keto acid dehydrogenase complex ^²
branched chain acyltransferase, E2 component ^²
dihydrolipoamide branched chain transacylase (E2 component of branched chain keto acid dehydrogenase complex; maple syrup urine disease) ^¹
dihydrolipoamide branched chain transacylase E2 ^²
dihydrolipoyl transacylase ^²
lipoamide acyltransferase component of mitochondrial branched-chain alpha-keto acid dehydrogenase complex ^²
mitochondrial branched chain alpha-keto acid dehydrogenase transacylase subunit (E2b) ^²

External Ids
HGNC: 2698¹
Entrez Gene: 1629²
UniProtKB: P11182³
Ensembl: ENSG00000137992⁷

Search outside databases for aliases for DBT gene

Previous GC identifers: GC01M101450 GC01M099840 GC01M099950 GC01M100122

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DBT:

The branched-chain alpha-keto acid dehydrogenase complex (BCKD) is an inner-mitochondrial enzyme

complex involved in the breakdown of the branched-chain amino acids isoleucine, leucine, and

valine. The BCKD complex is thought to be composed of a core of 24 transacylase (E2) subunits, and

associated decarboxylase (E1), dehydrogenase (E3), and regulatory subunits. This gene encodes the

transacylase (E2) subunit. Mutations in this gene result in maple syrup urine disease, type 2.

Alternatively spliced transcript variants have been described, but their biological validity has

not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: ODB2_HUMAN, P11182

Function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of

alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:

branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide

dehydrogenase (E3)

Gene Wiki entry for DBT

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DBT gene

Entrez Gene cytogenetic band: 1p31 Ensembl cytogenetic band: 1p21.2 HGNC cytogenetic band: 1p31

DBT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M100371: (about GC identifiers)

Start:	100,425,066 bp from pter
End:	100,487,997 bp from pter
Size:	62,932 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ODB2_HUMAN, P11182 (See protein sequence)

Recommended Name: Lipoamide acyltransferase component of branched-chain alpha-keto acid

dehydrogenase complex, mitochondrial precursor

Size: 482 amino acids; 53487 Da

Cofactor: Binds 1 lipoyl cofactor covalently

Subunit: Forms a 24-polypeptide structural core with octahedral symmetry

Subcellular location: Mitochondrion matrix

Miscellaneous: The catalytic function of this enzyme is to accept, and to transfer to coenzyme A,

acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component

PDB structures from and Proteopedia :

1K8M (3D)

1K8O (3D)

1ZWV (3D)

2COO (3D)

Secondary accessions: Q5VVL8

REFSEQ proteins: NP_001909.2

ENSEMBL proteins:

ENSP00000359151 ENSP00000359150

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DBT)
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: DBT

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	TAS	1429740
GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	TAS	1429740
GO:0042645	mitochondrial nucleoid	IDA	18063578

About this table

Antibodies for DBT:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DBT
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DBT), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DBT)
	Novus Biologicals Antibody for DBT

Assays for DBT:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11182

ProtoNet protein and cluster: P11182

4 Blocks protein families:

IPB000089 Biotin/lipoyl attachment

IPB001078 Catalytic domain of components of various dehydrogenase complexes

IPB003016 2-oxo acid dehydrogenase

IPB004167 E3 binding domain

UniProtKB/Swiss-Prot: ODB2_HUMAN, P11182

Similarity: Belongs to the 2-oxoacid dehydrogenase family

Similarity: Contains 1 lipoyl-binding domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DBT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001918

Applied Biosystems Silencer® siRNAs for DBT

Sigma-Aldrich siRNA and siRNA Panels for DBT

Sigma-Aldrich shRNA for DBT

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DBT
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001918
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001918
untagged cDNA clones in CMV expression vector (see all 2): NM_001918

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001918

UniProtKB/Swiss-Prot: ODB2_HUMAN, P11182

Function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of

alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:

branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide

dehydrogenase (E3)

Catalytic activity: 2-methylpropanoyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme

N(6)-(S-(2-methylpropanoyl)dihydrolipoyl)lysine

Enzyme Number (IUBMB): EC 2.3.1.168

Genatlas biochemistry entry for DBT:

branched chain keto acid dehydrogenase complex,E2 component (dihydrolipoamide branched chain

transacylase),inner mitochondrial membrane

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dbt):

behavior/neurological	homeostasis/metabolism	lethality-postnatal	life span-post-weaning/aging	renal/urinary system
respiratory system	skin/coat/nails

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IEA	--
GO:0008415	acyltransferase activity	IEA	--
GO:0016740	transferase activity	IEA	--
GO:0031405	lipoic acid binding	IEA	--
GO:0043754	dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/9 Sigma-Aldrich "Your Favorite Gene" Pathways for DBT (Your Favorite Gene powered by Ingenuity) (see all 9 )

Glycine, Serine and Threonine Metabolism
Butanoate Metabolism
Tyrosine Metabolism
Lysine Degradation
Valine, Leucine and Isoleucine Degradation

GeneDecks DBT for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for DBT

5/27 Interacting proteins for DBT (ENSP00000359151³ P11182²) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
TNFRSF1B	P20333²	MINT-49375
BCKDHB	ENSP00000318351³	STRING (score=.999)
DLD	ENSP00000205402³	STRING (score=.998)
PDHB	ENSP00000307241³	STRING (score=.984)
PDHA1	ENSP00000348062³	STRING (score=.966)

About this table

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008152	metabolic process	IEA	--
GO:0046949	acyl-CoA biosynthetic process	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DBT
10 Novoseek chemical compound relationships for DBT gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
dihydrolipoamide	82.26	10	17314104 (1), 18206651 (1), 18533943 (1), 2004553 (1) (see all 6)
lysophospholipid	70.46	2	15944408 (1)
mcat	63.56	2	17604051 (1), 16112872 (1)
arachidonic acid	56.04	7	1799879 (1), 1915836 (1), 15052324 (1), 1641397 (1) (see all 7)
phospholipid	51.89	4	15052324 (1), 19416646 (1), 8463317 (1), 11525380 (1)
fatty acid	47.64	3	16112872 (1), 11525380 (1), 15944408 (1)
pyruvate	41.50	9	9242632 (2), 9619647 (1), 18206651 (1), 2010537 (1) (see all 5)
lysophosphatidylcholine	36.70	1	7931340 (1)
lipid	0.00	1	10101262 (1)
calcium	0.00	1	9525960 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DBT)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001918

Sigma-Aldrich siRNA and siRNA Panels for DBT

Sigma-Aldrich shRNA for DBT

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001918

REFSEQ mRNAs for DBT gene:

NM_001918.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001918

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001918
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001918
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001918

Additional cDNA sequence:

AK024946.1 AK303941.1 AK313191.1 BC016675.1 BC030002.1 BT007372.1 J03208.1 M19301.1

M27093.1 X57677.1 X66785.1

10 DOTS entries:

DT.203263 DT.412512 DT.100729322 DT.100809024 DT.300636 DT.40226816 DT.91756865 DT.92066752

DT.97793134 DT.99980376

24/68 AceView cDNA sequences (see all 68 ):

CD251695 CF139042 BM542879 AA872542 AL041514 BC016675 BP372275 BU156508

C01073 BC030002 AL041515 BE897186 AL598493 BM452811 CD652199 BP353059

AA423895 AA386388 X57677 BG477803 CD655295 BI258905 X66785 AI744652

highest scoring ESTs for DBT:

M19301 AL598493 BC016675 BC030002 BE897186 BG399461 BI460289 BI597861 BM452811 BT007372

Unigene Cluster for DBT:

Dihydrolipoamide branched chain transacylase E2

Hs.709187 [show with all ESTs]

Unigene Representative Sequence: NM_001918

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for DBT

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10	^	11
SP1:																	-				-
SP2:

About this scheme

ECgene alternative splicing isoforms for DBT

2 Ensembl transcripts including schematic representations:

ENST00000370132 ENST00000370131

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DBT expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DBT

¹ / ² / ³

15 probe-sets matching DBT gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
86425_at²^{, 3}	U95-E	1	1.00	1.00	0.76	0.82	AI632010	0.40	1.00	0.76	1
37862_at²^{, 3}	U95-A	1	1.00	1.00	-0.03	0.40	M19301	1.00	1.00	1.00	1
51919_at²^{, 3}	U95-C	1	1.00	1.00	0.64	1.20	AI367373	0.40	1.00	0.76	1
205371_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M27093	0.80	1.00	0.91	1
244687_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI632010	0.40	1.00	0.76	1
205369_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	J03208	0.80	1.00	0.91	1
231919_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK024946	0.20	1.00	0.72	1
211196_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M19301	1.00	1.00	1.00	1
205370_x_at²^{, 3}	U133-A	26	1.00	0.67	--	--	NM_001918	0.60	1.00	0.82	1
205371_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
244687_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205369_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
231919_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211196_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205370_x_at²	U133Plus2	26	1.00	0.67	--	--	--	--	--	--	--

GeneDecks DBT for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CTTTTTCTCA

SOURCE GeneReport for Unigene cluster: Hs.709187
Expression variation in blood from EXPOLDB for DBT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DBT gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DBT¹	--	dihydrolipoamide branched chain transacylase E2	91.56(n) 90.66(a)	479929 XM_861633.1 XP_866726.1
chimpanzee (Pan troglodytes)	DBT¹	--	dihydrolipoamide branched chain transacylase E2	93.89(n) 92.54(a)	457056 XM_513591.2 XP_513591.2
cow (Bos taurus)	DBT¹	--	dihydrolipoamide branched chain transacylase E2	91.91(n) 91.91(a)	280759 NM_173905.2 NP_776330.1
rat (Rattus norvegicus)	Dbt¹	--	dihydrolipoamide branched chain transacylase E2	84.3(n) 87.55(a)	29611 XM_342328.3 XP_342329.3
mouse (Mus musculus)	Dbt^{1, 5}	3 (51.20 cM)⁵	dihydrolipoamide branched chain transacylase E2^{1, 5}	84.79(n)¹ 87.55(a)¹	13171¹ NM_010022.2¹ NP_034152.1¹ AA410012⁵ AK075831⁵ (see all 12)

About this table Species with no ortholog for DBT

ENSEMBL Gene Tree for DBT

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DBT gene

PDHX² DLAT²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/296 NCBI SNPs in DBT are shown (see all 296 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 65)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3806236^1,2	A,C,F,H	100488336(+)	`CTGAGG/CGATGA`	1	--	ng3¹		4	EU EA WA	416
	rs3806235^1,2	A,C,F,H	100488042(+)	`AACGCA/GCCTCC`	1	--	ng3¹		7	EU EA WA NA	562
	rs11166414^1,2	A,C,F,H	100433414(+)	`GTGAAG/AGTCTT`	1	--	ut3¹ ese³		4	EU EA WA	418
	rs3806238^1,2	A,C,F,H	100488379(+)	`GTGTAA/GCCGCC`	1	--	ng3¹		7	EU EA WA NA	548
--	rs12021720^1,2	A,C,F,H	100444648(+)	`CTGACC/TCACAG`	1	S/G	mis¹ ese³		13	EU EA WA NA	1248
	rs11166412^1,2	A,C,F,H	100428853(+)	`CTTCTT/CGGAAA`	1	--	ut3¹		11	EU EA WA NA	976
	rs2784174^1,2	A,C,F,H	100431166(-)	`AGGAGT/CGCAGC`	1	--	ut3¹		4	EU EA WA	412
	rs6701655^1,2	A,C,F,H	100429249(+)	`CCTTTC/TACCAT`	1	--	ut3¹		8	EU EA WA NA	616
	rs11166413^1,2	A,C,F,H	100429082(+)	`GTTTCA/GGACTA`	1	--	ut3¹		4	EU EA WA	416
	rs7520551^1,2	A,C,F,H	100488755(+)	`GAGCAG/ACTAGG`	1	--	ng3¹		8	EU EA WA	838

About this table

HapMap Linkage Disequilibrium images for DBT (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 248610 disorders: 248600

UniProtKB/Swiss-Prot: ODB2_HUMAN, P11182

Defects in DBT are the cause of maple syrup urine disease type 2 (MSUD2) [MIM:248600].

MSUD is an autosomal recessive disorder characterized by mental and physical retardation, feeding

problems, and a maple syrup odor to the urine

2 Novoseek disease relationships for DBT gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
maple syrup urine disease	92.99	14	8430702 (2), 14508502 (1), 1943690 (1), 9621512 (1) (see all 8)
tuberculosis	0.00	2	17604051 (1), 16112872 (1)

About this table

Genatlas disease: DBT

maple syrup urine disease

GeneTests: DBT

Maple Syrup Urine Disease

Human Gene Mutation Database: DBT
Genetic Association Database: DBT

(Possibly Related Articles in Doctor's Guide)
About This Section

Borderline Personality Disorder Improves With Intensive Psychotherapy

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/92 PubMed articles for DBT gene (see all 92 ):

Structure of the gene encoding dihydrolipoyl transacylase (E2) component of human branched chain alpha-keto acid dehydrogenase complex and characterization of an E2 pseudogene. (PubMed id 1429740)^{1, 2, 3, 4} Lau K.S....Chuang D.T. (1992)
The complete cDNA sequence for dihydrolipoyl transacylase (E2) of human branched-chain alpha-keto acid dehydrogenase complex. (PubMed id 1420314)^{1, 2, 3, 4} Lau K.S....Chuang D.T. (1992)
A 17-bp insertion and a Phe215-->Cys missense mutation in the dihydrolipoyl transacylase (E2) mRNA from a thiamine-responsive maple syrup urine disease patient WG-34. (PubMed id 1847055)^{1, 3, 4} Fisher C.W.... Chuang D.T. (1991)
Molecular basis of intermittent maple syrup urine disease: novel mutations in the E2 gene of the branched-chain alpha-keto acid dehydrogenase complex. (PubMed id 9621512)^{1, 3, 4} Tsuruta M.... Indo Y. (1998)
Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex. (PubMed id 11839747)^{1, 3, 4} Chang C.-F.... Huang T.-H. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Differential processing of human and rat E1 alpha precursors of the branched-chain alpha-keto acid dehydrogenase complex caused by an N- terminal proline in the rat sequence. (PubMed id 7918575)^{3, 4} Wynn R.M.... Chuang D.T. (1994)
Construction and nucleotide sequence of a cDNA encoding the full- length preprotein for human branched chain acyltransferase. (PubMed id 2708389)^{3, 4} Danner D.J.... Pruckler J. (1989)
Complete primary structure of the transacylase (E2b) subunit of the human branched chain alpha-keto acid dehydrogenase complex. (PubMed id 2742576)^{3, 4} Nobukuni Y.... Matsuda I. (1989)
Conservation of primary structure in the lipoyl-bearing and dihydrolipoyl dehydrogenase binding domains of mammalian branched- chain alpha-keto acid dehydrogenase complex: molecular cloning of human and bovine transacylase (E2) cDNAs. (PubMed id 2837277)^{3, 4} Lau K.S.... Chuang D.T. (1988)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1629	HGNC: 2698	AceView: DBT	Ensembl:ENSG00000137992	euGenes: HUgn1629
ECgene: DBT	H-InvDB: DBT

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=DBT

Licensable Technologies for DBT
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DBT:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DBT-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DBT		Antibodies for DBT
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DBT		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Search for Recombinant Proteins
	Antibodies (DBT)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (DBT)
	Antibodies (DBT)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for DBT

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for DBT

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
DBT Gene at Home site.
Version 2.41.1
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DBT Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for DBT

Summaries
for DBT

Genomic Location
for DBT

Proteins
for DBT

Protein Domains/
Families
for DBT

Gene Function
for DBT

Pathways & Interactions
for DBT

Drugs & Compounds
for DBT

Transcripts
for DBT

Expression
for DBT

Orthologs
for DBT

Paralogs
for DBT

SNPs/Variants
for DBT

Disorders & Mutations
for DBT

Medical News
for DBT

Publications
for DBT

Search for DBT

Genome Databases showing DBT

Other Databases showing DBT

Specialized Databases showing DBT

Licensable Technologies
for DBT

Services
for DBT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DBT Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor DBT

Summariesfor DBT

Genomic Locationfor DBT

Proteinsfor DBT

Protein Domains/Familiesfor DBT

Gene Functionfor DBT

Pathways & Interactionsfor DBT

Drugs & Compoundsfor DBT

Transcriptsfor DBT

Expression for DBT

Orthologsfor DBT

Paralogsfor DBT

SNPs/Variantsfor DBT

Disorders & Mutationsfor DBT

Medical Newsfor DBT

Publicationsfor DBT

Search for DBT

Genome Databases showing DBT

Other Databases showing DBT

Specialized Databases showing DBT

Licensable Technologiesfor DBT

Servicesfor DBT

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DBT

Summaries
for DBT

Genomic Location
for DBT

Proteins
for DBT

Protein Domains/
Families
for DBT

Gene Function
for DBT

Pathways & Interactions
for DBT

Drugs & Compounds
for DBT

Transcripts
for DBT

Expression
for DBT

Orthologs
for DBT

Paralogs
for DBT

SNPs/Variants
for DBT

Disorders & Mutations
for DBT

Medical News
for DBT

Publications
for DBT

Licensable Technologies
for DBT

Services
for DBT