Aliases for DBR1 Gene
External Ids for DBR1 Gene
Previous GeneCards Identifiers for DBR1 Gene
The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]
GeneCards Summary for DBR1 Gene
DBR1 (Debranching RNA Lariats 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and hydrolase activity, acting on ester bonds.
UniProtKB/Swiss-Prot for DBR1 Gene
Cleaves the 2-5 phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.