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Aliases for DBR1 Gene

Aliases for DBR1 Gene

  • Debranching RNA Lariats 1 2 3
  • Debranching Enzyme (S. Cerevisiae) Homolog 1 2
  • Debranching Enzyme Homolog 1 (S. Cerevisiae) 2
  • EC 3.1.-.- 4

External Ids for DBR1 Gene

Previous GeneCards Identifiers for DBR1 Gene

  • GC03M134853
  • GC03M138671
  • GC03M139161
  • GC03M139201
  • GC03M139202
  • GC03M139362
  • GC03M137879
  • GC03M135254

Summaries for DBR1 Gene

Entrez Gene Summary for DBR1 Gene

  • The protein encoded by this gene is an RNA lariat debranching enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]

GeneCards Summary for DBR1 Gene

DBR1 (Debranching RNA Lariats 1) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding and hydrolase activity, acting on ester bonds.

UniProtKB/Swiss-Prot for DBR1 Gene

  • Cleaves the 2-5 phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.

Gene Wiki entry for DBR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBR1 Gene

Genomics for DBR1 Gene

Regulatory Elements for DBR1 Gene

Genomic Location for DBR1 Gene

Chromosome:
3
Start:
138,160,988 bp from pter
End:
138,174,949 bp from pter
Size:
13,962 bases
Orientation:
Minus strand

Genomic View for DBR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DBR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBR1 Gene

Proteins for DBR1 Gene

  • Protein details for DBR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UK59-DBR1_HUMAN
    Recommended name:
    Lariat debranching enzyme
    Protein Accession:
    Q9UK59
    Secondary Accessions:
    • Q96GH0
    • Q9NXQ6

    Protein attributes for DBR1 Gene

    Size:
    544 amino acids
    Molecular mass:
    61555 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Cells lacking DBR1 show an inhibition of HIV-1 replication
    SequenceCaution:
    • Sequence=AAD53327.2; Type=Frameshift; Positions=450, 463; Evidence={ECO:0000305};

    Alternative splice isoforms for DBR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBR1 Gene

Proteomics data for DBR1 Gene at MOPED

Post-translational modifications for DBR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DBR1 Gene

Domains & Families for DBR1 Gene

Protein Domains for DBR1 Gene

Suggested Antigen Peptide Sequences for DBR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UK59

UniProtKB/Swiss-Prot:

DBR1_HUMAN :
  • Belongs to the lariat debranching enzyme family.
Family:
  • Belongs to the lariat debranching enzyme family.
genes like me logo Genes that share domains with DBR1: view

No data available for Gene Families for DBR1 Gene

Function for DBR1 Gene

Molecular function for DBR1 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:2435736};
UniProtKB/Swiss-Prot CatalyticActivity:
RNA processing activity that hydrolyzes the 2-5 phosphodiester linkage at the branchpoint of excised intron lariats
UniProtKB/Swiss-Prot Function:
Cleaves the 2-5 phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.

Enzyme Numbers (IUBMB) for DBR1 Gene

Gene Ontology (GO) - Molecular Function for DBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008419 RNA lariat debranching enzyme activity IMP 10982890
GO:0016787 hydrolase activity --
GO:0016788 hydrolase activity, acting on ester bonds --
GO:0044822 poly(A) RNA binding IDA 22658674
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DBR1: view

Animal Model Products

No data available for Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for DBR1 Gene

Localization for DBR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBR1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBR1 Gene COMPARTMENTS Subcellular localization image for DBR1 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for DBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10982890
genes like me logo Genes that share ontologies with DBR1: view

Pathways & Interactions for DBR1 Gene

SuperPathways for DBR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DBR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000375 RNA splicing, via transesterification reactions IMP 10982890
GO:0000398 mRNA splicing, via spliceosome IBA --
GO:0006397 mRNA processing --
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IMP 10982890
genes like me logo Genes that share ontologies with DBR1: view

No data available for Pathways by source and SIGNOR curated interactions for DBR1 Gene

Drugs & Compounds for DBR1 Gene

No Compound Related Data Available

Transcripts for DBR1 Gene

Unigene Clusters for DBR1 Gene

Debranching enzyme homolog 1 (S. cerevisiae):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DBR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBR1 Gene

No ASD Table

Relevant External Links for DBR1 Gene

GeneLoc Exon Structure for
DBR1
ECgene alternative splicing isoforms for
DBR1

Expression for DBR1 Gene

mRNA expression in normal human tissues for DBR1 Gene

Protein differential expression in normal tissues from HIPED for DBR1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (24.5), Lymph node (6.2), and Blymphocyte (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DBR1 Gene



SOURCE GeneReport for Unigene cluster for DBR1 Gene Hs.477700

genes like me logo Genes that share expression patterns with DBR1: view

Protein tissue co-expression partners for DBR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DBR1 Gene

Orthologs for DBR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DBR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DBR1 35
  • 89.73 (n)
  • 88.11 (a)
DBR1 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBR1 35
  • 91.18 (n)
  • 90.24 (a)
DBR1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbr1 35
  • 83.68 (n)
  • 86.87 (a)
Dbr1 16
Dbr1 36
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DBR1 35
  • 99.31 (n)
  • 99.44 (a)
DBR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbr1 35
  • 84.37 (n)
  • 85.37 (a)
oppossum
(Monodelphis domestica)
Mammalia DBR1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBR1 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBR1 35
  • 71.88 (n)
  • 74.05 (a)
DBR1 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBR1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbr1 35
  • 66.22 (n)
  • 66.22 (a)
MGC75873 35
zebrafish
(Danio rerio)
Actinopterygii dbr1 35
  • 58.63 (n)
  • 59.32 (a)
wufc08f08 35
dbr1 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7942 37
  • 50 (a)
ldbr 35
  • 56.23 (n)
  • 55.7 (a)
ldbr 36
  • 45 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006805 35
  • 50.61 (n)
  • 47.01 (a)
worm
(Caenorhabditis elegans)
Secernentea dbr-1 37
  • 44 (a)
dbr-1 35
  • 52.31 (n)
  • 47.28 (a)
dbr-1 36
  • 38 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DBR1 36
  • 34 (a)
OneToOne
DBR1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DBR1 35
  • 54.22 (n)
  • 54.87 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2439 35
rice
(Oryza sativa)
Liliopsida Os.33892 35
Os03g0725300 35
  • 53.36 (n)
  • 47.32 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.11880 35
corn
(Zea mays)
Liliopsida Zm.9438 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03409 35
  • 49.29 (n)
  • 46.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dbr1 35
  • 53.99 (n)
  • 51.9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8440 36
  • 57 (a)
OneToOne
Species with no ortholog for DBR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DBR1 Gene

ENSEMBL:
Gene Tree for DBR1 (if available)
TreeFam:
Gene Tree for DBR1 (if available)

Paralogs for DBR1 Gene

No data available for Paralogs for DBR1 Gene

Variants for DBR1 Gene

Sequence variations from dbSNP and Humsavar for DBR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs329379 -- 138,174,902(+) CCACC(G/T)CCTGG utr-variant-5-prime
rs329380 -- 138,175,235(+) TTGTT(G/T)AAAAA upstream-variant-2KB
rs774803 -- 138,176,776(+) AGTGA(A/G)GCCAA upstream-variant-2KB
rs811810 -- 138,176,506(+) TGGAA(A/T)ATTCT upstream-variant-2KB
rs811811 -- 138,171,908(+) AAAGG(C/T)AAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBR1 Gene

Variant ID Type Subtype PubMed ID
nsv428422 CNV Gain+Loss 18775914
dgv1511e1 CNV Complex 17122850
esv2751978 CNV Loss 17911159
dgv1512e1 CNV Complex 17122850
nsv877536 CNV Gain 21882294

Variation tolerance for DBR1 Gene

Residual Variation Intolerance Score: 36.05% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.47; 43.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBR1 Gene

HapMap Linkage Disequilibrium report
DBR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBR1 Gene

Disorders for DBR1 Gene

Relevant External Links for DBR1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBR1
genes like me logo Genes that share disorders with DBR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBR1 Gene

Publications for DBR1 Gene

  1. DBR1 siRNA inhibition of HIV-1 replication. (PMID: 16232320) Ye Y. … Camerini D. (Retrovirology 2005) 23 67
  2. Human RNA lariat debranching enzyme cDNA complements the phenotypes of Saccharomyces cerevisiae dbr1 and Schizosaccharomyces pombe dbr1 mutants. (PMID: 10982890) Kim J.-W. … Nam K. (Nucleic Acids Res. 2000) 2 67
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67

Products for DBR1 Gene

Sources for DBR1 Gene

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