V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

DBP Gene

protein-coding   GIFtS: 56

GC19M053825
D site of albumin promoter (albumin D-box) binding protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
DABP 1, 2
TAXREB302 3
Descriptions
Albumin D box-binding protein 3
Albumin D-element-binding protein 3
D site of albumin promoter (albumin D-box) binding protein 2
External Ids
HGNC: 26971
Entrez Gene: 16282
UniProtKB: Q105863
Ensembl: ENSG000001055167
Search outside databases for aliases for DBP gene

Previous GC identifers: GC19M049778 GC19M049501 GC19M053809

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DBP:
DBP is a member of the PAR bZIP (proline and acidic amino acid-rich basic leucine zipper)
transcription factor family (Khatib et al., 1994 [PubMed 7835883]).[supplied by OMIM]

UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586
Function: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3'
found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for
circadian rhythm generation, but modulates important clock output genes. May be a direct target
for regulation by the circadian pacemaker component clock. May affect circadian period and sleep
regulation

Gene Wiki entry for DBP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DBP gene  

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC chromosome: 19

DBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M053825:     (about GC identifiers)

Start:
53,825,659 bp from pter
End:
53,832,435 bp from pter
Size:
6,777 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586 (See protein sequence)
Recommended Name: D site-binding protein  
Size: 325 amino acids; 34349 Da
Subunit: Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF
Subcellular location: Nucleus

REFSEQ proteins: NP_001343.2  

ENSEMBL proteins: 
ENSP00000222122 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (D Box Binding Protein)
Human Recombinant Proteins from Abnova (DBP)
              OriGene Purified Recombinant Human Protein: DBP 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
About this table

Antibodies for DBP: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for DBP
Browse R&D Systems for Antibodies
Antibodies from Abcam (D Box Binding Protein), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (DBP)
Novus Biologicals Antibodies for DBP

Assays for DBP: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro domains/families:
 IPR004827 TF_bZIP
 IPR011700 bZIP_2


   GeneDecks  DBP for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q10586

ProtoNet protein and cluster: Q10586

UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586
Similarity: Belongs to the bZIP family. PAR subfamily
Similarity: Contains 1 bZIP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (DBP)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (DBP)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001352

              Applied Biosystems Silencer® siRNAs for DBP

              Sigma-Aldrich siRNA for DBP  
                     Sigma-Aldrich shRNA for DBP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001352
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001352
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001352 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001352

UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586
Function: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3'
found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for
circadian rhythm generation, but modulates important clock output genes. May be a direct target
for regulation by the circadian pacemaker component clock. May affect circadian period and sleep
regulation

Genatlas biochemistry entry for DBP:
albumin promoter (D site) binding protein,accumulating according to a robust circadian rythm in
liver and kidney

5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dbp):

behavior/neurologicalhomeostasis/metabolismlife span-post-weaning/agingnervous systemno phenotypic analysis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003700 transcription factor activity IEA--
GO:0003702 RNA polymerase II transcription factor activity TAS8786133
GO:0043565 sequence-specific DNA binding IEA--
GO:0046983 protein dimerization activity IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


 Gene Network CentralTM Interacting Genes and Proteins Network for  DBP 


1 Interacting protein for DBP (ENSP000002221223) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
SH3BP5ENSP000002536883STRING (score=.722)
About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006350 transcription IEA--
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS8786133
GO:0042127 regulation of cell proliferation IEA--
GO:0048511 rhythmic process IEA--
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DBP
1 Novoseek chemical compound relationship for DBP gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
leucine 43.89 3 15169930 (1), 1386162 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (DBP)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (DBP)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001352

              Sigma-Aldrich siRNA for DBP  
                     Sigma-Aldrich shRNA for DBP  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001352  

REFSEQ mRNAs for DBP gene: 

NM_001352.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001352  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001352
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001352
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001352 

Additional cDNA sequence: 

AF245447.1 AK000599.1 AK074601.1 AK122735.1 AK297787.1 AK300541.1 AL136701.1 BC006161.1 
BC010671.1 CR614720.1 D28468.1 EF107108.1 

24/38 DOTS entries (see all 38 ):

DT.100803883  DT.95162273  DT.100770536  DT.91790903  DT.115995  DT.100785328  DT.97822422  DT.100780604 
DT.91777742  DT.100730344  DT.100780605  DT.121411886  DT.99961873  DT.97857593  DT.100766101  DT.121412109 
DT.91984522  DT.40253235  DT.92429390  DT.97859980  DT.121412172  DT.95162274  DT.121411863  DT.100837254 

24/172 AceView cDNA sequences (see all 172 ):

AI818293 NM_001352 BM666583 CR616380 U79283 BM930012 BC011965 BG034689 
BM551849 CR590812 BQ447949 BM785887 BM929342 BQ183025 CB242774 AI471218 
CR604569 BM722740 BU628945 BM021389 CD674357 CD367793 BU622524 BM763856 

highest scoring ESTs for DBP:

AA018974 AL555115 BC011965 BF036033 BG034689 BG500217 BG766155 BI549618 BI757543 BI758403 

Unigene Clusters for DBP:

D site of albumin promoter (albumin D-box) binding protein
Hs.414480  [show with all ESTs], Hs.528006  [show with all ESTs]
Unigene Representative Sequences: AB208807, EF107108


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DBP

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1:                                -     -     -                           
SP2:                                            -                           
SP3:                                                                        
SP4:        -                                                               
SP5:                          -     -     -     -                           

About this scheme

ECgene alternative splicing isoforms for DBP

1 Ensembl transcript including schematic representation:
ENST00000222122  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DBP expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for DBP

1 / 2 / 3

5 probe-sets matching DBP gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
40274_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 U48213 0.20 1.00 0.72 1

209783_at2, 3 U133-A 1 1.00 1.00 -- -- D28468 0.40 0.67 0.55 1

209782_s_at2, 3 U133-A 1 1.00 1.00 -- -- U79283 0.80 1.00 0.91 1

209783_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

209782_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  DBP for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene clusters: Hs.414480 Hs.528006

Expression variation in blood from EXPOLDB for DBP

UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586
Tissue specificity: Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in
most peripheral tissues, with a strong circadian rhythmicity

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for DBP gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
cow
(Bos taurus)
DBP1   -- D site of albumin promoter (albumin D-box) binding more 89.95(n)
95.08(a)
503577  NM_001037445.1  NP_001032522.1 
rat
(Rattus norvegicus)
Dbp1   -- D site of albumin promoter (albumin D-box) binding more 85.85(n)
92.31(a)
24309  NM_012543.1  NP_036675.1 
mouse
(Mus musculus)
Dbp1, 5 7 (23.00 cM)5
D site albumin promoter binding protein1, 5 85.44(n)1
92.31(a)1
131701  NM_016974.11  NP_058670.11 
 AK1402435  AK1782885  (see all 14)
About this table        Species with no ortholog for DBP

ENSEMBL Gene Tree for DBP
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for DBP gene
TEF2  HLF2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/30 NCBI SNPs in DBP are shown (see all 30 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 24)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 19 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs10570201,2
C53832121(-) TGACTG/CGCAGG 1 -- ut51 ese35Minor allele frequency- C:0.00MN CSAM EA 408
rs3865511,2
A,C,F,H53830098(+) AACAAG/CATCCC 1 -- int110Minor allele frequency- C:0.41MN EU EA WA NA 1085
--
rs5504551,2
A,C,F,H53828327(+) GTCTTT/CATAAA 1 -- int16Minor allele frequency- C:0.47EA NA EU 346
rs37457341,2
F,H53826200(+) GCAGCG/CGGGCC 1 -- int15Minor allele frequency- C:0.17EA EU WA 1888
--
rs5473481,2
H53828291(+) gattaC/Aacgag 1 -- int14Minor allele frequency- A:0.00EU EA WA 416
--
rs81107851,2
A53827602(+) gtgctA/Gggatt 1 -- int10--------
rs126085441,2
C53828463(+) TGGCTA/GTGGGG 1 -- int10--------
--
rs48017711,2
C53827354(+) atgagC/Tgccac 1 -- int10--------
--
rs359827541,2
--53832164(+) GCCCA-/GGGGCG 1 -- ut510--------
--
rs561008791,2
--53828599(+) TCTTCA/GAGGGT 1 R/X non10--------
About this table

HapMap Linkage Disequilibrium images for DBP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 124097

Genetic Association Database: DBP
Human Genome Epidemiology Navigator: DBP (159 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/57 PubMed articles for DBP gene (see all 57 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1628 HGNC: 2697 AceView: DBP Ensembl:ENSG00000105516 euGenes: HUgn1628
ECgene: DBP H-InvDB: DBP
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for DBP:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for DBP-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for DBP Antibodies for DBP
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for DBP Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
 Antibodies   Primer Pairs  
 Cell Culture Products   ELISAs  
 Flow Cytometry Kits   Protease Activity Assays & Reagents  
 Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
 Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
 Recombinant & Natural Proteins  

 Recombinant Proteins (DBP)
 Antibodies (DBP)
 Chimera RNAi (DBP)
 Custom Service for Mouse Mab
 Custom Service for Rabbit Pab from Full-length Protein
  
 Search for Antibodies & Assays

 Recombinant Proteins
(D Box Binding Protein)
 Antibodies (D Box Binding Protein)
 Tagged/untagged cDNA clones
 Validated SYBR primer pairs
 Purified proteins from HEK293T cells
 Western blot validated antibodies
 shRNA in GFP-retroviral vector
 Search Tocris compounds for DBP




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for DBP

GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

Random Gene From GIFtS : about GIFtS

Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science



The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
DBP Gene at Home site.
Version 2.41.1
server5.xennexinc.com