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Aliases for DBP Gene

Aliases for DBP Gene

  • D Site Of Albumin Promoter (Albumin D-Box) Binding Protein 2 3
  • Tax-Responsive Enhancer Element-Binding Protein 302 3 4
  • Albumin D-Element-Binding Protein 3 4
  • Albumin D Box-Binding Protein 3 4
  • TaxREB302 3 4
  • D Site-Binding Protein 3
  • DABP 3

External Ids for DBP Gene

Summaries for DBP Gene

Entrez Gene Summary for DBP Gene

  • The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

GeneCards Summary for DBP Gene

DBP (D Site Of Albumin Promoter (Albumin D-Box) Binding Protein) is a Protein Coding gene. Diseases associated with DBP include hemophilia b and graves disease. Among its related pathways are Circadian Clock and Circadian Clock. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is TEF.

UniProtKB/Swiss-Prot for DBP Gene

  • This transcriptional activator recognizes and binds to the sequence 5-RTTAYGTAAY-3 found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation

Gene Wiki entry for DBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBP Gene

Genomics for DBP Gene

Genomic Location for DBP Gene

Start:
48,630,030 bp from pter
End:
48,637,438 bp from pter
Size:
7,409 bases
Orientation:
Minus strand

Genomic View for DBP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBP Gene

Regulatory Elements for DBP Gene

Proteins for DBP Gene

  • Protein details for DBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10586-DBP_HUMAN
    Recommended name:
    D site-binding protein
    Protein Accession:
    Q10586
    Secondary Accessions:
    • A2I2P4

    Protein attributes for DBP Gene

    Size:
    325 amino acids
    Molecular mass:
    34349 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF

neXtProt entry for DBP Gene

Proteomics data for DBP Gene at MOPED

Post-translational modifications for DBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for DBP Gene

Domains for DBP Gene

Protein Domains for DBP Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DBP_HUMAN
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • Q10586
Family:
  • Belongs to the bZIP family. PAR subfamily.:
    • Q10586
genes like me logo Genes that share domains with DBP: view

No data available for Gene Families for DBP Gene

Function for DBP Gene

Molecular function for DBP Gene

GENATLAS Biochemistry: albumin promoter (D site) binding protein,accumulating according to a robust circadian rythm in liver and kidney
UniProtKB/Swiss-Prot Function: This transcriptional activator recognizes and binds to the sequence 5-RTTAYGTAAY-3 found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation

Gene Ontology (GO) - Molecular Function for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 20093779
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 20093779
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with DBP: view
genes like me logo Genes that share phenotypes with DBP: view

Animal Models for DBP Gene

MGI Knock Outs for DBP:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DBP Gene

Localization for DBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBP Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBP Gene COMPARTMENTS Subcellular localization image for DBP gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DBP: view

Pathways for DBP Gene

genes like me logo Genes that share pathways with DBP: view

Pathways by source for DBP Gene

Gene Ontology (GO) - Biological Process for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS 8786133
GO:0007623 circadian rhythm TAS --
genes like me logo Genes that share ontologies with DBP: view

Compounds for DBP Gene

(1) Novoseek inferred chemical compound relationships for DBP Gene

Compound -log(P) Hits PubMed IDs
leucine 46.6 2
genes like me logo Genes that share compounds with DBP: view

Transcripts for DBP Gene

Unigene Clusters for DBP Gene

D site of albumin promoter (albumin D-box) binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DBP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3:
SP4: -
SP5: - - - -

Relevant External Links for DBP Gene

GeneLoc Exon Structure for
DBP
ECgene alternative splicing isoforms for
DBP

Expression for DBP Gene

mRNA expression in normal human tissues for DBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DBP Gene

SOURCE GeneReport for Unigene cluster for DBP Gene Hs.414480

mRNA Expression by UniProt/SwissProt for DBP Gene

Q10586-DBP_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity
genes like me logo Genes that share expressions with DBP: view

Orthologs for DBP Gene

This gene was present in the common ancestor of animals.

Orthologs for DBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA11 37
  • 100 (a)
OneToOne
DBP 36
  • 99.38 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia DBP 36
  • 89.95 (n)
  • 95.08 (a)
DBP 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBP 36
  • 90.67 (n)
  • 95.08 (a)
DBP 37
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbp 36
  • 85.74 (n)
  • 92.62 (a)
Dbp 16
Dbp 37
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBP 37
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbp 36
  • 85.85 (n)
  • 92.31 (a)
lizard
(Anolis carolinensis)
Reptilia DBP 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbp 36
  • 65.03 (n)
  • 63.4 (a)
zebrafish
(Danio rerio)
Actinopterygii dbpa 37
  • 38 (a)
OneToMany
dbpb 37
  • 35 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7786 37
  • 27 (a)
OneToMany
gt 37
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea atf-8 37
  • 16 (a)
OneToMany
ces-2 37
  • 22 (a)
OneToMany
Species with no ortholog for DBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DBP Gene

ENSEMBL:
Gene Tree for DBP (if available)
TreeFam:
Gene Tree for DBP (if available)

Paralogs for DBP Gene

Paralogs for DBP Gene

Selected SIMAP similar genes for DBP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DBP: view

Variants for DBP Gene

Sequence variations from dbSNP and Humsavar for DBP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs386551 -- 48,635,029(+) AACAA(C/G)ATCCC intron-variant, nc-transcript-variant
rs547348 -- 48,633,222(+) GATTA(A/C)ACGAG intron-variant, downstream-variant-500B
rs550455 -- 48,633,258(+) GTCTT(C/T)ATAAA intron-variant, downstream-variant-500B
rs3745734 -- 48,631,131(+) GCAGC(C/G)GGGCC intron-variant
rs3905524 -- 48,633,269(+) CCTCA(A/G)GCCCC intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DBP Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294

Relevant External Links for DBP Gene

HapMap Linkage Disequilibrium report
DBP

Disorders for DBP Gene

Relevant External Links for DBP

Genetic Association Database (GAD)
DBP
Human Genome Epidemiology (HuGE) Navigator
DBP
genes like me logo Genes that share disorders with DBP: view

No data available for UniProtKB/Swiss-Prot for DBP Gene

Publications for DBP Gene

  1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PMID: 7835883) Khatib Z.A. … Look A.T. (Genomics 1994) 2 3 4 23
  2. Genomic structure of the human D-site binding protein (DBP) gene. (PMID: 8786133) Shutler G. … Mueller C.R. (Genomics 1996) 3 4 23
  3. A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma. (PMID: 20093779) Takahashi S. … Katayama S. (J. Atheroscler. Thromb. 2010) 3 23
  4. Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). (PMID: 1535333) Szpirer C. … Szpirer J. (Genomics 1992) 2 3
  5. Cloning of a cDNA encoding a DNA-binding protein TAXREB302 that is specific for the tax-responsive enhancer of HTLV-I. (PMID: 8482542) Nyunoya H. … Shimotohno K. (Gene 1993) 3 4

Products for DBP Gene

Sources for DBP Gene

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