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Aliases for DBP Gene

Aliases for DBP Gene

  • D-Box Binding PAR BZIP Transcription Factor 2 3
  • D Site Of Albumin Promoter (Albumin D-Box) Binding Protein 2 3 5
  • Tax-Responsive Enhancer Element-Binding Protein 302 3 4
  • Albumin D-Element-Binding Protein 3 4
  • Albumin D Box-Binding Protein 3 4
  • TaxREB302 3 4
  • DABP 3

External Ids for DBP Gene

Previous GeneCards Identifiers for DBP Gene

  • GC19M049778
  • GC19M049501
  • GC19M053809
  • GC19M053825
  • GC19M049133
  • GC19M045513

Summaries for DBP Gene

Entrez Gene Summary for DBP Gene

  • The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythm genes. [provided by RefSeq, Jul 2014]

GeneCards Summary for DBP Gene

DBP (D-Box Binding PAR BZIP Transcription Factor) is a Protein Coding gene. Among its related pathways are BMAL1-CLOCK,NPAS2 activates circadian gene expression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is TEF.

UniProtKB/Swiss-Prot for DBP Gene

  • This transcriptional activator recognizes and binds to the sequence 5-RTTAYGTAAY-3 found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

Gene Wiki entry for DBP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBP Gene

Genomics for DBP Gene

Regulatory Elements for DBP Gene

Promoters for DBP Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DBP on UCSC Golden Path with GeneCards custom track

Genomic Location for DBP Gene

Chromosome:
19
Start:
48,630,030 bp from pter
End:
48,637,550 bp from pter
Size:
7,521 bases
Orientation:
Minus strand

Genomic View for DBP Gene

Genes around DBP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBP Gene

Proteins for DBP Gene

  • Protein details for DBP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q10586-DBP_HUMAN
    Recommended name:
    D site-binding protein
    Protein Accession:
    Q10586
    Secondary Accessions:
    • A2I2P4

    Protein attributes for DBP Gene

    Size:
    325 amino acids
    Molecular mass:
    34349 Da
    Quaternary structure:
    • Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF.

neXtProt entry for DBP Gene

Proteomics data for DBP Gene at MOPED

Post-translational modifications for DBP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBP Gene

No data available for DME Specific Peptides for DBP Gene

Domains & Families for DBP Gene

Gene Families for DBP Gene

Protein Domains for DBP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DBP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q10586

UniProtKB/Swiss-Prot:

DBP_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. PAR subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. PAR subfamily.
genes like me logo Genes that share domains with DBP: view

Function for DBP Gene

Molecular function for DBP Gene

GENATLAS Biochemistry:
albumin promoter (D site) binding protein,accumulating according to a robust circadian rythm in liver and kidney
UniProtKB/Swiss-Prot Function:
This transcriptional activator recognizes and binds to the sequence 5-RTTAYGTAAY-3 found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulation.

Gene Ontology (GO) - Molecular Function for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 20093779
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA,IDA 20093779
genes like me logo Genes that share ontologies with DBP: view
genes like me logo Genes that share phenotypes with DBP: view

Animal Models for DBP Gene

MGI Knock Outs for DBP:

Animal Model Products

miRNA for DBP Gene

miRTarBase miRNAs that target DBP

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBP Gene

Localization for DBP Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBP Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBP Gene COMPARTMENTS Subcellular localization image for DBP gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for DBP Gene

Pathways & Interactions for DBP Gene

genes like me logo Genes that share pathways with DBP: view

Pathways by source for DBP Gene

Gene Ontology (GO) - Biological Process for DBP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA,IDA 20093779
genes like me logo Genes that share ontologies with DBP: view

No data available for SIGNOR curated interactions for DBP Gene

Drugs & Compounds for DBP Gene

(22) Drugs for DBP Gene - From: Novoseek and ClinicalTrials

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Doxazosin Approved Pharma 54
Valsartan Approved, Investigational Pharma Antagonist Angiotensin II AT1 receptor antagonist, High affinity, selective AT1 antagonist 268
Ergocalciferol Approved Nutra 923
Adrenergic Agents Pharma 4204
Adrenergic alpha-1 Receptor Antagonists Pharma 405
genes like me logo Genes that share compounds with DBP: view

Transcripts for DBP Gene

Unigene Clusters for DBP Gene

D site of albumin promoter (albumin D-box) binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DBP Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
SP1: - - -
SP2: -
SP3:
SP4: -
SP5: - - - -

Relevant External Links for DBP Gene

GeneLoc Exon Structure for
DBP
ECgene alternative splicing isoforms for
DBP

Expression for DBP Gene

mRNA expression in normal human tissues for DBP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DBP Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DBP Gene



SOURCE GeneReport for Unigene cluster for DBP Gene Hs.414480

mRNA Expression by UniProt/SwissProt for DBP Gene

Q10586-DBP_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity.
genes like me logo Genes that share expression patterns with DBP: view

Protein tissue co-expression partners for DBP Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DBP Gene

Orthologs for DBP Gene

This gene was present in the common ancestor of animals.

Orthologs for DBP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CA11 36
  • 100 (a)
OneToOne
DBP 35
  • 99.38 (n)
  • 100 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia DBP 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbp 36
  • 93 (a)
OneToOne
Dbp 16
Dbp 35
  • 85.74 (n)
  • 92.62 (a)
dog
(Canis familiaris)
Mammalia DBP 36
  • 95 (a)
OneToOne
DBP 35
  • 90.67 (n)
  • 95.08 (a)
cow
(Bos Taurus)
Mammalia DBP 36
  • 95 (a)
OneToOne
DBP 35
  • 89.95 (n)
  • 95.08 (a)
rat
(Rattus norvegicus)
Mammalia Dbp 35
  • 85.85 (n)
  • 92.31 (a)
lizard
(Anolis carolinensis)
Reptilia DBP 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbp 35
  • 65.03 (n)
  • 63.4 (a)
zebrafish
(Danio rerio)
Actinopterygii dbpb 36
  • 35 (a)
OneToMany
dbpa 36
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gt 36
  • 12 (a)
OneToMany
CG7786 36
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ces-2 36
  • 22 (a)
OneToMany
atf-8 36
  • 16 (a)
OneToMany
Species with no ortholog for DBP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DBP Gene

ENSEMBL:
Gene Tree for DBP (if available)
TreeFam:
Gene Tree for DBP (if available)

Paralogs for DBP Gene

Paralogs for DBP Gene

(2) SIMAP similar genes for DBP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DBP: view

Variants for DBP Gene

Sequence variations from dbSNP and Humsavar for DBP Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs386551 -- 48,635,029(+) AACAA(C/G)ATCCC intron-variant, nc-transcript-variant
rs547348 -- 48,633,222(+) GATTA(A/C)ACGAG intron-variant, downstream-variant-500B
rs550455 -- 48,633,258(+) GTCTT(C/T)ATAAA intron-variant, downstream-variant-500B
rs3745734 -- 48,631,131(+) GCAGC(C/G)GGGCC intron-variant
rs4801771 -- 48,632,285(+) ATGAG(C/T)GCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBP Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
dgv3966n71 CNV Loss 21882294
nsv912225 CNV Loss 21882294
dgv3967n71 CNV Loss 21882294

Variation tolerance for DBP Gene

Residual Variation Intolerance Score: 61.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.12; 22.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBP Gene

HapMap Linkage Disequilibrium report
DBP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBP Gene

Disorders for DBP Gene

Relevant External Links for DBP

Genetic Association Database (GAD)
DBP
Human Genome Epidemiology (HuGE) Navigator
DBP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBP

No disorders were found for DBP Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBP Gene

Publications for DBP Gene

  1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PMID: 7835883) Khatib Z.A. … Look A.T. (Genomics 1994) 2 3 4 23 67
  2. A promoter in the novel exon of hPPARgamma directs the circadian expression of PPARgamma. (PMID: 20093779) Takahashi S. … Katayama S. (J. Atheroscler. Thromb. 2010) 3 23
  3. Genomic structure of the human D-site binding protein (DBP) gene. (PMID: 8786133) Shutler G. … Mueller C.R. (Genomics 1996) 3 23
  4. Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). (PMID: 1535333) Szpirer C. … Szpirer J. (Genomics 1992) 2 3
  5. Upregulation of D site of albumin promoter binding protein in the brain of patients with intractable epilepsy. (PMID: 25503293) Yuan J. … Chen Y. (Mol Med Rep 2015) 3

Products for DBP Gene

Sources for DBP Gene

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