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Aliases & Descriptions for DBP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DABP 1, 2 | | TAXREB302 3 |
| | | Descriptions |
|---|
| Albumin D box-binding protein 3 | | Albumin D-element-binding protein 3 | | D site of albumin promoter (albumin D-box) binding protein 2 |
|
| | Search outside databases for aliases for DBP genePrevious GC identifers: GC19M049778 GC19M049501 GC19M053809 |
Summaries for DBP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for DBP: DBP is a member of the PAR bZIP (proline and acidic amino acid-rich basic leucine zipper) transcription factor family (Khatib et al., 1994 [PubMed 7835883]).[supplied by OMIM] UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586Function: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulationGene Wiki entry for DBP |
Genomic Location for DBP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DBP gene 
Entrez Gene cytogenetic band: 19q13.3 Ensembl cytogenetic band: 19q13.33 HGNC chromosome: 19DBP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M053825:
(about GC identifiers)
Start:
|
53,825,659 bp from pter |
End:
|
53,832,435 bp from pter |
Size:
|
6,777 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for DBP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586 (See
protein sequence)Recommended Name: D site-binding protein Size: 325 amino acids; 34349 Da
Subunit: Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF
Subcellular location: NucleusREFSEQ proteins: NP_001343.2
ENSEMBL proteins: ENSP00000222122
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: DBP 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- | About this table
Antibodies for DBP: Assays for DBP: | Protein
Domains/ Families for DBP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q10586
ProtoNet protein and cluster: Q10586 UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586Similarity: Belongs to the bZIP family. PAR subfamilySimilarity: Contains 1 bZIP domain | Gene Function for DBP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001352
Applied Biosystems Silencer® siRNAs for DBP
Sigma-Aldrich siRNA for DBP  Sigma-Aldrich shRNA for DBP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001352                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001352                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001352 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001352
UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586Function: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker component clock. May affect circadian period and sleep regulationGenatlas biochemistry entry for DBP:albumin promoter (D site) binding protein,accumulating according to a robust circadian rythm in liver and kidney5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Dbp):
4 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003700 | transcription factor activity |
IEA | -- | | GO:0003702 | RNA polymerase II transcription factor activity |
TAS | 8786133 | | GO:0043565 | sequence-specific DNA binding |
IEA | -- | | GO:0046983 | protein dimerization activity |
IEA | -- | About this table | Pathways & Interactions for DBP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for DBP 
1 Interacting protein for DBP (ENSP000002221223) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for DBP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for DBP 1 Novoseek chemical compound relationship for DBP gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| leucine |
43.89 |
3 |
15169930 (1), 1386162 (1) |
About this table
|
Transcripts for DBP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001352
Sigma-Aldrich siRNA for DBP  Sigma-Aldrich shRNA for DBP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001352 REFSEQ mRNAs for DBP gene: NM_001352.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001352               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001352                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001352                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001352  Additional cDNA sequence: AF245447.1 AK000599.1 AK074601.1 AK122735.1 AK297787.1 AK300541.1 AL136701.1 BC006161.1 BC010671.1 CR614720.1 D28468.1 EF107108.1 24/38 DOTS entries (see all 38
): DT.100803883 DT.95162273 DT.100770536 DT.91790903 DT.115995 DT.100785328 DT.97822422 DT.100780604 DT.91777742 DT.100730344 DT.100780605 DT.121411886 DT.99961873 DT.97857593 DT.100766101 DT.121412109 DT.91984522 DT.40253235 DT.92429390 DT.97859980 DT.121412172 DT.95162274 DT.121411863 DT.100837254 24/172 AceView cDNA sequences (see all 172
):AI818293 NM_001352 BM666583 CR616380 U79283 BM930012 BC011965 BG034689 BM551849 CR590812 BQ447949 BM785887 BM929342 BQ183025 CB242774 AI471218 CR604569 BM722740 BU628945 BM021389 CD674357 CD367793 BU622524 BM763856
highest scoring ESTs for DBP:AA018974 AL555115 BC011965 BF036033 BG034689 BG500217 BG766155 BI549618 BI757543 BI758403 Unigene Clusters for DBP: D site of albumin promoter (albumin D-box) binding protein Hs.414480 [show with all ESTs], Hs.528006 [show with all ESTs]Unigene Representative Sequences: AB208807, EF107108
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for DBP
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | |   | |   | |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for DBP
1 Ensembl transcript including schematic representation: ENST00000222122
|
Expression for DBP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DBP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DBP
1 / 2 / 3 5 probe-sets matching DBP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.414480 Hs.528006
Expression variation in blood from EXPOLDB for DBP UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586Tissue specificity: Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral tissues, with a strong circadian rhythmicity |
Orthologs for DBP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DBP gene from 3 species
About this table Species with no ortholog for DBP
ENSEMBL Gene Tree for DBP | Paralogs for DBP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for DBP gene
- TEF2 HLF2
|
SNPs/Variants for DBP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DBP (up to first 250kb)
|
Disorders & Mutations for DBP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 124097
Genetic Association Database: DBP Human Genome Epidemiology Navigator: DBP (159 documents)
|
Medical News for DBP(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DBP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/57 PubMed articles for DBP gene (see all 57
):- Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PubMed id 7835883)1, 2, 3, 4 Khatib Z.A....Look A.T. (1994)
- Genomic structure of the human D-site binding protein (DBP) gene. (PubMed id 8786133)1, 3, 4 Shutler G.... Mueller C.R. (1996)
- Vitamin D-binding protein gene polymorphism association with IA-2 autoantibodies in type 1 diabetes. (PubMed id 15820770)3, 6 Ongagna J.C....Belcourt A. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Association of molecular variants, haplotypes, and linkage disequilibrium within the human vitamin D-binding protein (DBP) gene with postmenopausal bone mineral density. (PubMed id 12968673)3, 6 Ezura Y....Emi M. (2003)
- No association of vitamin D-binding protein gene polymorphisms in Japanese patients with MS. (PubMed id 12044990)3, 6 Niino M....Tashiro K. (2002)
- Vitamin D binding protein gene and genetic susceptibility to type 2 diabetes mellitus in a Polish population. (PubMed id 12062854)3, 6 Malecki M.T....Sieradzki J. (2002)
- Variations in the vitamin D-binding protein (Gc locus) and risk of type 2 diabetes mellitus in French Caucasians. (PubMed id 11230793)3, 6 Ye W.Z....Velho G. (2001)
- The ins and outs of circadian timekeeping. (PubMed id 10508692)3, 4 Brown S.A. and Schibler U. (1999)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)3, 4 Yu W....Gibbs R.A. (1997)
|
Search for DBP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DBP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DBP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DBP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for DBP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for DBP:

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Incremental update: 13 Oct 2009
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