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DBP Gene

protein-coding   GIFtS: 55
GCID: GC19M049133

D Site Of Albumin Promoter (Albumin D-Box) Binding Protein

Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
D Site Of Albumin Promoter (Albumin D-Box) Binding Protein1 2     DABP2
Albumin D Box-Binding Protein2 3     D Site-Binding Protein2
Albumin D-Element-Binding Protein2 3     taxREB3022
Tax-Responsive Enhancer Element-Binding Protein 3022 3     TaxREB3023

External Ids:    HGNC: 26971   Entrez Gene: 16282   Ensembl: ENSG000001055167   OMIM: 1240975   UniProtKB: Q105863   

Export aliases for DBP gene to outside databases

Previous GC identifers: GC19M049778 GC19M049501 GC19M053809 GC19M053825 GC19M045513


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DBP Gene:
The protein encoded by this gene is a member of the PAR bZIP transcription factor family and binds to specific
sequences in the promoters of several genes, such as albumin, CYP2A4, and CYP2A5. The encoded protein can bind
DNA as a homo- or heterodimer and is involved in the regulation of some circadian rhythym genes. (provided by
RefSeq, Jan 2012)

GeneCards Summary for DBP Gene:
DBP (D site of albumin promoter (albumin D-box) binding protein) is a protein-coding gene. Diseases associated with DBP include graves disease 3, and gonadal dysgenesis, xx type. GO annotations related to this gene include RNA polymerase II regulatory region sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is TEF.

UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586
Function: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the
promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but
modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker
component clock. May affect circadian period and sleep regulation

Gene Wiki entry for DBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DBP gene promoter:
         COUP-TF1   CREB   ATF-2   deltaCREB   COUP   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDBP promoter sequence
   Search Chromatin IP Primers for DBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.3   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.33

DBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049133:  view genomic region     (about GC identifiers)

Start:
49,133,287 bp from pter      End:
49,140,695 bp from pter
Size:
7,409 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586 (See protein sequence)
Recommended Name: D site-binding protein  
Size: 325 amino acids; 34349 Da
Subunit: Binds DNA as a homodimer or a heterodimer. Can form a heterodimer with TEF
Secondary accessions: A2I2P4

Explore the universe of human proteins at neXtProt for DBP: NX_Q10586

Explore proteomics data for DBP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001343.2  
    ENSEMBL proteins: 
     ENSP00000222122   ENSP00000469426   ENSP00000471220   ENSP00000469291  
    Reactome Protein details: Q10586

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry Q10586

    ProtoNet protein and cluster: Q10586

    UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586
    Similarity: Belongs to the bZIP family. PAR subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    DBP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DBP_HUMAN, Q10586
    Function: This transcriptional activator recognizes and binds to the sequence 5'-RTTAYGTAAY-3' found in the
    promoter of genes such as albumin, CYP2A4 and CYP2A5. It is not essential for circadian rhythm generation, but
    modulates important clock output genes. May be a direct target for regulation by the circadian pacemaker
    component clock. May affect circadian period and sleep regulation

         Genatlas biochemistry entry for DBP:
    albumin promoter (D site) binding protein,accumulating according to a robust circadian rythm in liver and kidney

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000977RNA polymerase II regulatory region sequence-specific DNA binding IDA--
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0043565sequence-specific DNA binding ----
         
    DBP for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DBP:
     Decreased G3BP1 protein expres  Increased S DNA content 

         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dbp):
     behavior/neurological  homeostasis/metabolism  mortality/aging  nervous system  no phenotypic analysis 

    DBP for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dbptm2Schb for DBP

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DBP

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    5 qRT-PCR Assays for microRNAs that regulate DBP:
    hsa-miR-1321 hsa-miR-513c hsa-miR-514b-5p hsa-miR-486-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidDBP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DBP

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    GenScript: all cDNA clones in your preferred vector: DBP (NM_001352)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBP

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DBP_HUMAN, Q10586: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    DBP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DBP About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Circadian Clock
    Circadian Clock0.66
    BMAL1-CLOCK/NPAS2 Activates Circadian Expression0.66

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for DBP
        BMAL1:CLOCK,NPAS2 activates circadian gene expression



    DBP for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DBP: 
              Circadian Rhythms in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for DBP (Q105863 ENSP000002221224) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CLOCKO155163, ENSP000003087414I2D: score=2 STRING: ENSP00000308741
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    HLFQ165343, ENSP000002260674I2D: score=3 STRING: ENSP00000226067
    EP300Q094723, ENSP000002632534I2D: score=2 STRING: ENSP00000263253
    TEFQ105873, ENSP000002663044I2D: score=3 STRING: ENSP00000266304
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter TAS8786133
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IDA--
    GO:0048511rhythmic process IEA--

    DBP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DBP

    1 Novoseek inferred chemical compound relationship for DBP gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 46.6 4 15169930 (1), 1386162 (1)



    DBP for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DBP gene: 
    NM_001352.4  

    Unigene Cluster for DBP:

    D site of albumin promoter (albumin D-box) binding protein
    Hs.414480  [show with all ESTs]
    Unigene Representative Sequence: AB208807
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000222122(uc002pjx.4 uc002pjy.2 uc010elz.1) ENST00000599385
    ENST00000594723 ENST00000593500 ENST00000601104
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate DBP:
    hsa-miR-1321 hsa-miR-513c hsa-miR-514b-5p hsa-miR-486-3p hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidDBP 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DBP
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    GenScript: all cDNA clones in your preferred vector: DBP (NM_001352)
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    Primer
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    OriGene qPCR primer pairs and template standards for DBP
    OriGene qSTAR qPCR primer pairs in human, mouse for DBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBP
      QuantiTect SYBR Green Assays in human, mouse, rat DBP
      QuantiFast Probe-based Assays in human, mouse, rat DBP

    Additional mRNA sequence: 

    AB208807.1 AK310025.1 BC011965.1 BT006836.1 U06936.1 U79283.1 

    12 DOTS entries:

    DT.100803883  DT.95162273  DT.100770536  DT.100780604  DT.100780605  DT.91984522  DT.97859980  DT.100837254 
    DT.40253235  DT.100774496  DT.121412155  DT.75199549 

    Selected AceView cDNA sequences (see all 172):

    CR604569 AU106739 BU526861 BM977412 BM929342 BM718624 BU617851 BM785887 
    CR621936 BM708885 CD367793 CR616380 BM551849 CR614226 AI471218 BM930012 
    NM_001352 CA450328 BM722740 CK904258 BM693068 BQ109568 CA396884 F26608 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DBP    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b · 6c
    SP1:                                -     -     -                           
    SP2:                                            -                           
    SP3:                                                                        
    SP4:        -                                                               
    SP5:                          -     -     -     -                           


    ECgene alternative splicing isoforms for DBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DBP expression in normal human tissues (normalized intensities)      DBP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGGCAA
    DBP Expression
    About this image


    DBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Cerebral Cortex
             Olfactory Bulb   
    DBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.414480

    UniProtKB/Swiss-Prot: DBP_HUMAN, Q10586
    Tissue specificity: Ubiquitously expressed. Expressed in the suprachiasmatic nuclei (SCN) and in most peripheral
    tissues, with a strong circadian rhythmicity

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DBP: 
              Circadian Rhythms in human mouse rat
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DBP gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dbp1 , 5 D site albumin promoter binding protein1, 5 85.74(n)1
    92.62(a)1
      7 (29.45 cM)5
    131701  NM_016974.31  NP_058670.21 
     457050885 
    lizard
    (Anolis carolinensis)
    Reptilia DBP6
    D site of albumin promoter (albumin D-box) binding...
    61(a)
    1 ↔ 1
    GL343279.1(887480-909720)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dbp1 D site of albumin promoter (albumin D-box) binding more 65.03(n)
    63.4(a)
      100494503  XM_002938278.2  XP_002938324.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dbpa6
    dbpb6
    D site of albumin promoter (albumin D-box) binding...
    D site of albumin promoter (albumin D-box) binding...
    38(a)
    35(a)
    many → 1
    many → 1
    19(10799651-10818906) ENSDARG00000063014
    16(15351114-15364896) ENSDARG00000057652
    fruit fly
    (Drosophila melanogaster)
    Insecta CG77866
    gt6
    giant
    27(a)
    12(a)
    many → 1
    many → 1
    2R(12121863-12122441)
    X(2321140-2322996)
    worm
    (Caenorhabditis elegans)
    Secernentea ces-26
    atf-86
    Protein ATF-8 (atf-8) mRNA, complete cds
    22(a)
    16(a)
    many → 1
    many → 1
    I(14961501-14965355) WBGene00000469
    V(6105675-6107531) WBGene00017535


    ENSEMBL Gene Tree for DBP (if available)
    TreeFam Gene Tree for DBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DBP gene
    TEF2  HLF2  
    2 SIMAP similar genes for DBP using alignment to 3 protein entries:     DBP_HUMAN (see all proteins):
    TEF    HLF

    DBP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DBP (see all 95)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2009678971,2
    --49134220(+) CGCACC/TGATAT 2 S syn10--------
    rs1475399711,2
    C,F--49134235(+) TTCTCC/TTTGAG 2 K syn11Minor allele frequency- T:0.00NA 4442
    rs1415902141,2
    C--49134322(+) GAAGA-/GGGGGG 1 -- int10--------
    rs577463261,2
    C,F--49134371(+) AGAGGA/GAGGGA 1 -- int11Minor allele frequency- G:0.23WA 118
    rs37457341,2
    C,F,H--49134388(+) GCAGCG/CGGGCC 1 -- int113Minor allele frequency- C:0.18EA NS WA NA CSA 2256
    rs1415676611,2
    --49134407(+) ACCAGA/GTCTCT 1 -- int10--------
    rs72528091,2
    C,H--49134417(+) TGCTGG/AGATAG 1 -- int13Minor allele frequency- A:0.00NS NA 230
    rs739448421,2
    C,F--49134529(+) CTTCAA/CGTCTC 1 -- int12Minor allele frequency- C:0.10WA 120
    rs739448431,2
    C--49134556(+) CCCCAG/ACCCTC 1 -- int12Minor allele frequency- A:0.07WA 120
    rs1459175081,2
    --49134673(+) TGCCCC/TGCCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for DBP (49133287 - 49140695 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DBP:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3967n71CNV Loss21882294
    nsv912225CNV Loss21882294
    dgv3966n71CNV Loss21882294
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124097    OMIM disorders: --

    Selected diseases for DBP (see all 27):    About MalaCards
    graves disease 3    gonadal dysgenesis, xx type    d-bifunctional protein deficiency    bipolar i disorder
    hemophilia b    hemophilia    temporal lobe epilepsy    schizoaffective disorder
    gonadal dysgenesis    protein s deficiency    mood disorder    bipolar disorder
    graves' disease    osteoporosis    type 1 diabetes    parkinson's disease
    multiple sclerosis    diabetes mellitus    schizophrenia    obesity


    DBP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): DBP
    Human Genome Epidemiology (HuGE) Navigator: DBP (229 documents)

    Export disorders for DBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DBP gene, integrated from 10 sources (see all 76):
    (articles sorted by number of sources associating them with DBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Chromosomal localization and cDNA cloning of the human DBP and TEF genes. (PubMed id 7835883)1, 2, 3, 9 Khatib Z.A.... Look A.T. (Genomics 1994)
    2. Genomic structure of the human D-site binding protein (DBP) gene. (PubMed id 8786133)1, 2, 9 Shutler G.... Mueller C.R. (Genomics 1996)
    3. Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis. (PubMed id 20007432)1, 4 Simon K.C....Ascherio A. (Mult. Scler. 2010)
    4. Differential association of circadian genes with mood disorders: CRY1 and NPAS2 are associated with unipolar major depression and CLOCK and VIP with bipolar disorder. (PubMed id 20072116)1, 4 Soria V....Urretavizcaya M. (Neuropsychopharmacology 2010)
    5. Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance. (PubMed id 20174623)1, 4 Utge S.J....Paunio T. (PLoS ONE 2010)
    6. PER2 variantion is associated with depression vulnerability. (PubMed id 19693801)1, 4 Lavebratt C....Forsell Y. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    7. Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families. (PubMed id 19543766)1, 4 Xu X.H....Deng H.W. (Osteoporos Int 2010)
    8. Vitamin D binding protein genotype and osteoporosis. (PubMed id 19488670)1, 4 Fang Y....Uitterlinden A.G. (Calcif. Tissue Int. 2009)
    9. Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation. (PubMed id 19302999)1, 4 Fu L....Cole D.E. (Clin. Biochem. 2009)
    10. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. (PubMed id 19839995)1, 4 Mansour H.A....Nimgaonkar V.L. (Bipolar Disord 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1628 HGNC: 2697 AceView: DBP Ensembl:ENSG00000105516 euGenes: HUgn1628
    ECgene: DBP H-InvDB: DBP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DBP gene:
    Search GeneIP for patents involving DBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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