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Aliases for DBNL Gene

Aliases for DBNL Gene

  • Drebrin-Like 2 3
  • HPK1-Interacting Protein Of 55 KDa 3 4
  • Cervical Mucin-Associated Protein 3 4
  • SH3 Domain-Containing Protein 7 3 4
  • Cervical SH3P7 3 4
  • Drebrin-F 3 4
  • HIP-55 3 4
  • HIP55 3 6
  • SH3P7 3 4
  • Src Homology 3 Domain-Containing Protein HIP-55 3
  • Drebrin-Like Protein 3
  • CMAP 4
  • ABP1 3

External Ids for DBNL Gene

Previous GeneCards Identifiers for DBNL Gene

  • GC07U990153
  • GC07P043857
  • GC07P044050
  • GC07P044084
  • GC07P043969

Summaries for DBNL Gene

GeneCards Summary for DBNL Gene

DBNL (Drebrin-Like) is a Protein Coding gene. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and B cell receptor signaling pathway (KEGG). GO annotations related to this gene include actin binding and protein domain specific binding. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot for DBNL Gene

  • Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Gene Wiki entry for DBNL Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBNL Gene

Genomics for DBNL Gene

Regulatory Elements for DBNL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DBNL Gene

Start:
44,044,640 bp from pter
End:
44,069,456 bp from pter
Size:
24,817 bases
Orientation:
Plus strand

Genomic View for DBNL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DBNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBNL Gene

Proteins for DBNL Gene

  • Protein details for DBNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJU6-DBNL_HUMAN
    Recommended name:
    Drebrin-like protein
    Protein Accession:
    Q9UJU6
    Secondary Accessions:
    • A4D2I9
    • B4DDP6
    • B4DEM2
    • C9J7P1
    • P84070
    • Q6IAI8
    • Q96F30
    • Q96K74
    • Q9HBN8
    • Q9NR72

    Protein attributes for DBNL Gene

    Size:
    430 amino acids
    Molecular mass:
    48207 Da
    Quaternary structure:
    • Interacts with SHANK2, SHANK3 and SYN1. Interacts with FGD1 and DNM1. Interacts with ANKRD54. Interacts with COBL. Interacts with WASL and WIPF1 (By similarity). Interacts with MAP4K1 and PRAM1.

    Three dimensional structures from OCA and Proteopedia for DBNL Gene

    Alternative splice isoforms for DBNL Gene

neXtProt entry for DBNL Gene

Proteomics data for DBNL Gene at MOPED

Post-translational modifications for DBNL Gene

No data available for DME Specific Peptides for DBNL Gene

Domains for DBNL Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJU6

UniProtKB/Swiss-Prot:

DBNL_HUMAN :
  • Q9UJU6
Domain:
  • The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1
  • Contains 1 ADF-H domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the ABP1 family.
genes like me logo Genes that share domains with DBNL: view

No data available for Gene Families for DBNL Gene

Function for DBNL Gene

Molecular function for DBNL Gene

GENATLAS Biochemistry: drebrin (actin-binding protein)-like
UniProtKB/Swiss-Prot Function: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Gene Ontology (GO) - Molecular Function for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IEA --
GO:0008047 enzyme activator activity TAS 10567356
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with DBNL: view
genes like me logo Genes that share phenotypes with DBNL: view

Animal Models for DBNL Gene

MGI Knock Outs for DBNL:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DBNL Gene

Localization for DBNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBNL Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Cell junction, synapse. Cell projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBNL Gene COMPARTMENTS Subcellular localization image for DBNL gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
plasma membrane 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0001726 ruffle ISS --
GO:0002102 podosome ISS --
GO:0005622 intracellular --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with DBNL: view

Pathways for DBNL Gene

genes like me logo Genes that share pathways with DBNL: view

Gene Ontology (GO) - Biological Process for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006897 endocytosis --
GO:0006898 receptor-mediated endocytosis IEA --
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
genes like me logo Genes that share ontologies with DBNL: view

Transcripts for DBNL Gene

Unigene Clusters for DBNL Gene

Drebrin-like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DBNL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBNL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - - - - -
SP9: - - -
SP10: -
SP11: - -

ExUns: 13c · 13d · 13e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DBNL Gene

GeneLoc Exon Structure for
DBNL
ECgene alternative splicing isoforms for
DBNL

Expression for DBNL Gene

mRNA expression in normal human tissues for DBNL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBNL Gene

This gene is overexpressed in Whole Blood (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DBNL Gene

SOURCE GeneReport for Unigene cluster for DBNL Gene Hs.436500

genes like me logo Genes that share expressions with DBNL: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DBNL Gene

Orthologs for DBNL Gene

This gene was present in the common ancestor of animals.

Orthologs for DBNL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBNL 35
  • 99.39 (n)
  • 99.54 (a)
DBNL 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DBNL 35
  • 88.26 (n)
  • 87.94 (a)
DBNL 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 87 (a)
OneToMany
DBNL 35
  • 85.3 (n)
  • 86.37 (a)
mouse
(Mus musculus)
Mammalia Dbnl 35
  • 84.06 (n)
  • 86.37 (a)
Dbnl 16
Dbnl 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DBNL 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBNL 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbnl 35
  • 84.49 (n)
  • 85.19 (a)
chicken
(Gallus gallus)
Aves DBNL 35
  • 73.27 (n)
  • 70.56 (a)
DBNL 36
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBNL 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbnl 35
  • 66.27 (n)
  • 66.19 (a)
zebrafish
(Danio rerio)
Actinopterygii dbnla 36
  • 47 (a)
OneToMany
dbnlb 35
  • 67.15 (n)
  • 62.44 (a)
dbnlb 36
  • 55 (a)
OneToMany
wufb34f02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012240 35
  • 49.45 (n)
  • 40.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10083 35
  • 58.24 (n)
  • 48.66 (a)
CG10083 36
  • 31 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K08E3.4 35
  • 49.89 (n)
  • 40 (a)
K08E3.4 36
  • 22 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3471 36
  • 35 (a)
OneToMany
Species with no ortholog for DBNL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DBNL Gene

ENSEMBL:
Gene Tree for DBNL (if available)
TreeFam:
Gene Tree for DBNL (if available)

Paralogs for DBNL Gene

Paralogs for DBNL Gene

genes like me logo Genes that share paralogs with DBNL: view

Variants for DBNL Gene

Sequence variations from dbSNP and Humsavar for DBNL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs12511 -- 44,061,403(-) ACCAC(A/C)ATGAT utr-variant-3-prime
rs4377865 -- 44,059,693(+) GAAGG(A/G)GCTGC intron-variant
rs4582459 -- 44,059,266(+) TGCCT(C/T)GAGCA intron-variant
rs4724276 -- 44,045,936(+) ACATC(C/T)TCTGT intron-variant
rs4724277 -- 44,057,211(+) ACTGG(A/C)ACATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBNL Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV Gain 18775914
nsv830980 CNV Loss 17160897
nsv8082 CNV Gain 18304495
nsv887996 CNV Loss 21882294
nsv470210 CNV Loss 18288195

Relevant External Links for DBNL Gene

HapMap Linkage Disequilibrium report
DBNL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBNL Gene

Disorders for DBNL Gene

No disorders were found for DBNL Gene.

No data available for UniProtKB/Swiss-Prot for DBNL Gene

Publications for DBNL Gene

  1. Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. (PMID: 11689006) Chen Y.-R. … Tan T.-H. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  2. Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. (PMID: 14729663) Le Bras S. … Deckert M. (J. Biol. Chem. 2004) 3 4 23
  3. NMR solution structures of actin depolymerizing factor homology domains. (PMID: 19768801) Goroncy A.K. … Yokoyama S. (Protein Sci. 2009) 4 23
  4. SH3P7 is a cytoskeleton adapter protein and is coupled to signal transduction from lymphocyte antigen receptors. (PMID: 9891087) Larbolette O. … Wienands J. (Mol. Cell. Biol. 1999) 3 4
  5. Genetic mapping of eight SH3 domain genes on seven mouse chromosomes. (PMID: 10087302) Lee C.G. … Kozak C.A. (Mamm. Genome 1999) 2 3

Products for DBNL Gene

Sources for DBNL Gene

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