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Aliases for DBNL Gene

Aliases for DBNL Gene

  • Drebrin Like 2 3 5
  • HPK1-Interacting Protein Of 55 KDa 2 3 4
  • Cervical Mucin-Associated Protein 3 4
  • SH3 Domain-Containing Protein 7 3 4
  • Actin-Binding Protein 1 2 3
  • Cervical SH3P7 3 4
  • Drebrin-F 3 4
  • HIP-55 3 4
  • SH3P7 3 4
  • Src Homology 3 Domain-Containing Protein HIP-55 3
  • Drebrin-Like Protein 3
  • Drebrin-Like 2
  • HIP55 3
  • ABP1 3
  • CMAP 4

External Ids for DBNL Gene

Previous GeneCards Identifiers for DBNL Gene

  • GC07U990153
  • GC07P043857
  • GC07P044050
  • GC07P044084
  • GC07P043969

Summaries for DBNL Gene

GeneCards Summary for DBNL Gene

DBNL (Drebrin Like) is a Protein Coding gene. Among its related pathways are Protein-protein interactions at synapses and Innate Immune System. GO annotations related to this gene include actin binding and protein C-terminus binding. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot for DBNL Gene

  • Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Gene Wiki entry for DBNL Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBNL Gene

Genomics for DBNL Gene

Regulatory Elements for DBNL Gene

Enhancers for DBNL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G044043 1.7 FANTOM5 ENCODE dbSUPER 7.4 +1.1 1125 4.1 HDGF HNRNPUL1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 POLM RASA4CP ENSG00000241057 ENSG00000239556 DBNL STK17A MIR6837
GH07G043903 1.3 ENCODE dbSUPER 5.4 -139.1 -139078 3.6 FOXA2 MLX AGO1 ARID4B SIN3A DMAP1 YY1 FOS SP3 SP5 ENSG00000239556 URGCP POLM RASA4CP DBNL URGCP-MRPS24 MRPS24
GH07G043925 1.1 ENCODE 5 -117.9 -117893 2.2 HDGF PKNOX1 MLX CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 DDX56 POLM SPDYE1 TUBG1P ENSG00000272768 POLD2 RASA4CP DBNL UBE2D4 PIR62464
GH07G043567 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.8 -473.9 -473921 6.6 ATF1 WRNIP1 ZNF766 ELK1 FOS JUNB REST TBX21 ZNF592 CREB3 COA1 LUARIS BLVRA STK17A DBNL
GH07G044064 1 Ensembl ENCODE 4.8 +21.0 21003 1.6 CTCF PKNOX1 AGO1 TEAD4 CEBPG RBBP5 RAD21 ZIC2 ZNF664 HIC1 POLM LINC00957 DBNL ENSG00000239775 PGAM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DBNL on UCSC Golden Path with GeneCards custom track

Promoters for DBNL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000211775 260 1401 HDGF HNRNPUL1 PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143

Genomic Location for DBNL Gene

Chromosome:
7
Start:
44,044,640 bp from pter
End:
44,069,456 bp from pter
Size:
24,817 bases
Orientation:
Plus strand

Genomic View for DBNL Gene

Genes around DBNL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBNL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBNL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBNL Gene

Proteins for DBNL Gene

  • Protein details for DBNL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UJU6-DBNL_HUMAN
    Recommended name:
    Drebrin-like protein
    Protein Accession:
    Q9UJU6
    Secondary Accessions:
    • A4D2I9
    • B4DDP6
    • B4DEM2
    • C9J7P1
    • P84070
    • Q6IAI8
    • Q96F30
    • Q96K74
    • Q9HBN8
    • Q9NR72

    Protein attributes for DBNL Gene

    Size:
    430 amino acids
    Molecular mass:
    48207 Da
    Quaternary structure:
    • Interacts with SHANK2, SHANK3 and SYN1. Interacts with FGD1 and DNM1. Interacts with ANKRD54. Interacts with COBL. Interacts with WASL and WIPF1 (By similarity). Interacts with MAP4K1 and PRAM1.

    Three dimensional structures from OCA and Proteopedia for DBNL Gene

    Alternative splice isoforms for DBNL Gene

neXtProt entry for DBNL Gene

Post-translational modifications for DBNL Gene

No data available for DME Specific Peptides for DBNL Gene

Domains & Families for DBNL Gene

Graphical View of Domain Structure for InterPro Entry

Q9UJU6

UniProtKB/Swiss-Prot:

DBNL_HUMAN :
  • The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.
  • Belongs to the ABP1 family.
Domain:
  • The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1.
Family:
  • Belongs to the ABP1 family.
genes like me logo Genes that share domains with DBNL: view

No data available for Gene Families for DBNL Gene

Function for DBNL Gene

Molecular function for DBNL Gene

GENATLAS Biochemistry:
drebrin (actin-binding protein)-like
UniProtKB/Swiss-Prot Function:
Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes.

Gene Ontology (GO) - Molecular Function for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding ISS --
GO:0005515 protein binding IPI 16189514
GO:0008022 protein C-terminus binding IEA --
GO:0008047 enzyme activator activity TAS 10567356
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with DBNL: view
genes like me logo Genes that share phenotypes with DBNL: view

Animal Models for DBNL Gene

MGI Knock Outs for DBNL:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBNL Gene

Localization for DBNL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBNL Gene

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle. Cytoplasm, cell cortex. Cytoplasm, cytosol. Cell junction, synapse. Cell projection. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome. Early endosome. Note=Detected in neuron cell body and cell projections, such as neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton. Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes (By similarity). {ECO:0000250 UniProtKB:Q62418}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBNL gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
plasma membrane 3
nucleus 3
golgi apparatus 3
endosome 3

Gene Ontology (GO) - Cellular Components for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0001726 ruffle ISS --
GO:0002102 podosome ISS --
GO:0005576 extracellular region TAS --
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with DBNL: view

Pathways & Interactions for DBNL Gene

genes like me logo Genes that share pathways with DBNL: view

SIGNOR curated interactions for DBNL Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DBNL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002250 adaptive immune response IEA --
GO:0002376 immune system process IEA --
GO:0006810 transport IEA --
GO:0006897 endocytosis IEA --
GO:0006898 receptor-mediated endocytosis IEA --
genes like me logo Genes that share ontologies with DBNL: view

Drugs & Compounds for DBNL Gene

No Compound Related Data Available

Transcripts for DBNL Gene

Unigene Clusters for DBNL Gene

Drebrin-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBNL Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ·
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - - - - -
SP9: - - -
SP10: -
SP11: - -

ExUns: 13c · 13d · 13e
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for DBNL Gene

GeneLoc Exon Structure for
DBNL
ECgene alternative splicing isoforms for
DBNL

Expression for DBNL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBNL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBNL Gene

This gene is overexpressed in Whole Blood (x7.0).

Protein differential expression in normal tissues from HIPED for DBNL Gene

This gene is overexpressed in Lymph node (10.2), Peripheral blood mononuclear cells (10.2), and Bone marrow stromal cell (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DBNL Gene



Protein tissue co-expression partners for DBNL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DBNL Gene:

DBNL

SOURCE GeneReport for Unigene cluster for DBNL Gene:

Hs.436500

Evidence on tissue expression from TISSUES for DBNL Gene

  • Nervous system(5)
  • Blood(4.7)
  • Eye(4.3)
  • Liver(4.2)
  • Lung(3.6)
  • Spleen(3.4)
  • Intestine(3.2)
  • Skin(3.2)
  • Kidney(2.9)
  • Lymph node(2.2)
genes like me logo Genes that share expression patterns with DBNL: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBNL Gene

Orthologs for DBNL Gene

This gene was present in the common ancestor of animals.

Orthologs for DBNL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBNL 34 35
  • 99.39 (n)
cow
(Bos Taurus)
Mammalia DBNL 34 35
  • 88.26 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 87 (a)
OneToMany
DBNL 34
  • 85.3 (n)
-- 35
  • 62 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Dbnl 34
  • 84.49 (n)
mouse
(Mus musculus)
Mammalia Dbnl 34 16 35
  • 84.06 (n)
oppossum
(Monodelphis domestica)
Mammalia DBNL 35
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBNL 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBNL 34 35
  • 73.27 (n)
lizard
(Anolis carolinensis)
Reptilia DBNL 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbnl 34
  • 66.27 (n)
zebrafish
(Danio rerio)
Actinopterygii dbnlb 34 35
  • 67.15 (n)
dbnla 35
  • 47 (a)
OneToMany
wufb34f02 34
fruit fly
(Drosophila melanogaster)
Insecta CG10083 34 35
  • 58.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012240 34
  • 49.45 (n)
worm
(Caenorhabditis elegans)
Secernentea K08E3.4 34 35
  • 49.89 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3471 35
  • 35 (a)
OneToMany
Species where no ortholog for DBNL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DBNL Gene

ENSEMBL:
Gene Tree for DBNL (if available)
TreeFam:
Gene Tree for DBNL (if available)

Paralogs for DBNL Gene

Paralogs for DBNL Gene

genes like me logo Genes that share paralogs with DBNL: view

Variants for DBNL Gene

Sequence variations from dbSNP and Humsavar for DBNL Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000009538 -- 44,044,189(+) AGCGG(G/T)GTGAT intron-variant, upstream-variant-2KB
rs1000281497 -- 44,058,075(+) GCAGG(A/G)GATTA intron-variant
rs1000435799 -- 44,047,242(+) CTCGG(A/C/T)GCTTG intron-variant
rs1000901391 -- 44,053,607(+) AATGT(C/T)TTGGA intron-variant
rs1001477237 -- 44,050,759(+) CTTGG(A/C)CAGCA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DBNL Gene

Variant ID Type Subtype PubMed ID
nsv428165 CNV gain 18775914
nsv470210 CNV loss 18288195
nsv8082 CNV gain 18304495
nsv830980 CNV loss 17160897
nsv966788 CNV duplication 23825009

Variation tolerance for DBNL Gene

Residual Variation Intolerance Score: 66.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.86; 34.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBNL Gene

Human Gene Mutation Database (HGMD)
DBNL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBNL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBNL Gene

Disorders for DBNL Gene

Relevant External Links for DBNL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBNL

No disorders were found for DBNL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBNL Gene

Publications for DBNL Gene

  1. Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. (PMID: 14729663) Le Bras S. … Deckert M. (J. Biol. Chem. 2004) 3 4 22 64
  2. Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. (PMID: 11689006) Chen Y.-R. … Tan T.-H. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 64
  3. NMR solution structures of actin depolymerizing factor homology domains. (PMID: 19768801) Goroncy A.K. … Yokoyama S. (Protein Sci. 2009) 4 22 64
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for DBNL Gene

Sources for DBNL Gene

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