Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DBNL Gene

protein-coding   GIFtS: 56
GCID: GC07P044084

Drebrin-Like

  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
drebrin-like1 2     HIP552 5
Cervical Mucin-Associated Protein2 3     ABP12
Cervical SH3P72 3     drebrin-F2
HIP-552 3     Drebrin-Like Protein2
SH3P72 3     Src Homology 3 Domain-Containing Protein HIP-552
HPK1-Interacting Protein Of 55 KDa2 3     CMAP3
SH3 Domain-Containing Protein 72 3     Drebrin-F3

External Ids:    HGNC: 26961   Entrez Gene: 289882   Ensembl: ENSG000001362797   OMIM: 6101065   UniProtKB: Q9UJU63   

Export aliases for DBNL gene to outside databases

Previous GC identifers: GC07U990153 GC07P043857 GC07P044050 GC07P043969


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for DBNL Gene:
DBNL (drebrin-like) is a protein-coding gene. GO annotations related to this gene include actin binding and protein domain specific binding. An important paralog of this gene is DBN1.

UniProtKB/Swiss-Prot: DBNL_HUMAN, Q9UJU6
Function: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis.
Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in
neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and
promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By
similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key
component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin
cytoskeleton to gene activation and endocytic processes

Gene Wiki entry for DBNL (Drebrin-like) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000007.13  NC_018918.2  NT_007819.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DBNL gene promoter:
         Pax-5   AP-1   HTF   ATF-2   CUTL1   c-Jun   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DBNL promoter sequence
   Search Chromatin IP Primers for DBNL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DBNL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p13   Ensembl cytogenetic band:  7p13   HGNC cytogenetic band: 7p13

DBNL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBNL gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P044084:  view genomic region     (about GC identifiers)

Start:
44,084,239 bp from pter      End:
44,109,055 bp from pter
Size:
24,817 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 44,123,733-44,140,805     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DBNL_HUMAN, Q9UJU6 (See protein sequence)
Recommended Name: Drebrin-like protein  
Size: 430 amino acids; 48207 Da
Subunit: Interacts with SHANK2, SHANK3 and SYN1. Interacts with FGD1 and DNM1. Interacts with ANKRD54. Interacts
with COBL. Interacts with WASL and WIPF1 (By similarity). Interacts with MAP4K1 and PRAM1
1 PDB 3D structure from and Proteopedia for DBNL:
1X67 (3D)    
Secondary accessions: A4D2I9 P84070 Q6IAI8 Q96F30 Q96K74 Q9HBN8 Q9NR72
Alternative splicing: 3 isoforms:  Q9UJU6-1   Q9UJU6-2   Q9UJU6-3   (No experimental confirmation available. Contains a phosphoserine at position 232)

Explore the universe of human proteins at neXtProt for DBNL: NX_Q9UJU6

Explore proteomics data for DBNL at MOPED

Post-translational modifications: 

  • Degraded by caspases during apoptosis1
  • Ubiquitination2 at Lys164
  • Modification sites at PhosphoSitePlus

  • See DBNL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001014436.1  NP_001116428.1  NP_001271242.1  NP_001271244.1  NP_054782.2  

    ENSEMBL proteins: 
     ENSP00000411701   ENSP00000416421   ENSP00000403372   ENSP00000415173   ENSP00000392113  
     ENSP00000418006   ENSP00000410681   ENSP00000418978   ENSP00000405343   ENSP00000418301  
     ENSP00000400817   ENSP00000417653   ENSP00000415395   ENSP00000419992   ENSP00000390397  
     ENSP00000398931   ENSP00000397855   ENSP00000417749  
    Reactome Protein details: Q9UJU6

    DBNL Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for DBNL
    OriGene Protein Over-expression Lysate for DBNL
    OriGene MassSpec for DBNL
    OriGene Custom Protein Services for DBNL
    GenScript Custom Purified and Recombinant Proteins Services for DBNL
    Novus Biologicals DBNL Proteins
    Novus Biologicals DBNL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DBNL

     
    Search eBioscience for Proteins for DBNL 

    DBNL Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for DBNL
    OriGene Custom Antibody Services for DBNL
    Novus Biologicals DBNL Antibodies
    Abcam antibodies for DBNL
    Cloud-Clone Corp. Antibodies for DBNL
    ThermoFisher Antibodies for DBNL
    LSBio Antibodies in human, mouse, rat for DBNL

    DBNL Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DBNL
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DBNL
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DBNL
    Cloud-Clone Corp. CLIAs for DBNL
    Search eBioscience for ELISAs for DBNL 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR002108 Actin-bd_cofilin/tropomyosin
     IPR001452 SH3_domain

    Graphical View of Domain Structure for InterPro Entry Q9UJU6

    ProtoNet protein and cluster: Q9UJU6

    2 Blocks protein domains:
    IPB001452 SH3 domain signature
    IPB002108 Actin-binding


    UniProtKB/Swiss-Prot: DBNL_HUMAN, Q9UJU6
    Domain: The SH3 domain mediates interaction with SHANK2, SHANK3 and PRAM1
    Similarity: Belongs to the ABP1 family
    Similarity: Contains 1 ADF-H domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with DBNL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DBNL_HUMAN, Q9UJU6
    Function: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis.
    Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in
    neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and
    promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By
    similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key
    component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin
    cytoskeleton to gene activation and endocytic processes

         Genatlas biochemistry entry for DBNL:
    drebrin (actin-binding protein)-like

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding ISS--
    GO:0005515protein binding IPI16189514
    GO:0008022protein C-terminus binding IEA--
    GO:0008047enzyme activator activity TAS10567356
    GO:0019904protein domain specific binding IEA--
         
    Find genes that share ontologies with DBNL           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dbnl):
     behavior/neurological  cardiovascular system  growth/size/body  hematopoietic system  homeostasis/metabolism 
     immune system  integument  mortality/aging  nervous system  reproductive system 
     respiratory system 

    Find genes that share phenotypes with DBNL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dbnltm1Jwnd for DBNL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DBNL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DBNL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DBNL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DBNL

    miRNA
    Products:
        
    miRTarBase miRNAs that target DBNL:
    hsa-mir-3187-3p (MIRT052809), hsa-mir-222-3p (MIRT046641), hsa-mir-26b-5p (MIRT028810), hsa-mir-193b-3p (MIRT041370), hsa-let-7b-5p (MIRT051893), hsa-mir-7-5p (MIRT025775), hsa-mir-124-3p (MIRT022629)

    Block miRNA regulation of human, mouse, rat DBNL using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DBNL:
    hsa-miR-345 hsa-miR-9 hsa-miR-133a hsa-miR-1208 hsa-miR-133b hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidDBNL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DBNL
    Predesigned siRNA for gene silencing in human, mouse, rat DBNL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DBNL

    Clone
    Products:
         
    OriGene clones in human, mouse for DBNL (see all 19)
    OriGene ORF clones in mouse, rat for DBNL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DBNL (NM_001122956)
    Sino Biological Human cDNA Clone for DBNL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBNL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBNL

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DBNL
    Browse ESI BIO Cell Lines and PureStem Progenitors for DBNL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBNL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DBNL_HUMAN, Q9UJU6: Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, ruffle (By
    similarity). Cytoplasm, cell cortex (By similarity). Cytoplasm, cytosol (By similarity). Cell junction, synapse
    (By similarity). Cell projection (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side
    (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic
    side (By similarity). Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity).
    Cell projection, podosome (By similarity). Note=Detected in neuron cell body and cell projections, such as
    neurites. Colocalizes with cytosolic dynamin in hippocampus neurons (By similarity). Cortical actin cytoskeleton.
    Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots
    and podosome rosettes (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    plasma membrane5
    cytosol4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0001726ruffle ISS--
    GO:0002102podosome ISS--
    GO:0005622intracellular ----
    GO:0005737cytoplasm ISS--

    Find genes that share ontologies with DBNL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DBNL About    
    See pathways by source

    SuperPathContained pathways About
    1Apoptotic cleavage of cellular proteins
    Apoptotic cleavage of cellular proteins0.74
    Caspase-mediated cleavage of cytoskeletal proteins0.00
    Apoptotic execution phase0.74
    2TCR signaling in naive CD4+ T cells
    TCR signaling in naive CD4+ T cells0.64
    3CDK-mediated phosphorylation and removal of Cdc6
    Apoptosis0.38
    4B cell receptor signaling pathway (KEGG)
    TCR Signaling Pathway0.36
    5JNK signaling in the CD4+ TCR pathway
    JNK signaling in the CD4+ TCR pathway


    Find genes that share SuperPaths with DBNL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for DBNL
        TCR Signaling Pathway
    TCR signaling in naive CD4+ T cells
    JNK signaling in the CD4+ TCR pathway


    1 Reactome Pathway for DBNL
        Caspase-mediated cleavage of cytoskeletal proteins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DBNL
    Interactions:

        GeneGlobe Interaction Network for DBNL

    Selected Interacting proteins for DBNL (Q9UJU61, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 113)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002376immune system process IEA--
    GO:0006897endocytosis IEA--
    GO:0006915apoptotic process TAS--
    GO:0006921cellular component disassembly involved in execution phase of apoptosis TAS--
    GO:0007257activation of JUN kinase activity TAS10567356

    Find genes that share ontologies with DBNL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DBNL



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DBNL gene (5 alternative transcripts): 
    NM_001014436.2  NM_001122956.1  NM_001284313.1  NM_001284315.1  NM_014063.6  

    Unigene Cluster for DBNL:

    Drebrin-like
    Hs.436500  [show with all ESTs]
    Unigene Representative Sequence: NM_001122956
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000448521 ENST00000456905 ENST00000458579 ENST00000439983 ENST00000440166
    ENST00000441840 ENST00000464762 ENST00000439815 ENST00000498733 ENST00000452943
    ENST00000485932 ENST00000429716 ENST00000468694 ENST00000441904 ENST00000494774(uc003tjo.4 uc003tjq.4 uc003tjp.4 uc011kbm.2 uc011kbo.2 uc011kbp.2 uc011kbq.2 uc011kbn.2 uc011kbr.2 uc011kbs.2)
    ENST00000411855 ENST00000423561 ENST00000497184
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DBNL using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate DBNL:
    hsa-miR-345 hsa-miR-9 hsa-miR-133a hsa-miR-1208 hsa-miR-133b hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidDBNL 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DBNL
    Predesigned siRNA for gene silencing in human, mouse, rat DBNL
    Clone
    Products:
         
    OriGene clones in human, mouse for DBNL (see all 19)
    OriGene ORF clones in mouse, rat for DBNL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DBNL (NM_001122956)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBNL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBNL
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DBNL
    OriGene qSTAR qPCR primer pairs in human, mouse for DBNL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBNL
      QuantiTect SYBR Green Assays in human, mouse, rat DBNL
      QuantiFast Probe-based Assays in human, mouse, rat DBNL

    Additional mRNA sequence: 

    AF077353.1 AF151364.1 AF197060.1 AF218020.3 AF250287.1 AK027367.1 AK293151.1 AK293279.1 
    AK293340.1 AK293698.1 AK296778.1 AK298102.1 AK300630.1 AK302037.1 BC011677.2 BC031687.1 
    CR457167.1 

    Selected DOTS entries (see all 30):

    DT.100753359  DT.100766319  DT.100828795  DT.216295  DT.410016  DT.100828797  DT.121041177  DT.121040879 
    DT.100828798  DT.100828803  DT.121041104  DT.101984853  DT.100828799  DT.92451241  DT.100031036  DT.100828804 
    DT.101984852  DT.121040919  DT.121041081  DT.100828808  DT.121041117  DT.91912582  DT.100828806  DT.102830948 

    Selected AceView cDNA sequences (see all 527):

    AW571830 BG676427 BM810093 BM751546 BQ053514 BQ690891 BQ881240 BM808785 
    BG180312 BQ671230 BQ059925 BQ650216 CR606615 BM547379 AK126142 BU147065 
    BG177219 BG740854 CR626558 BQ063383 BQ670258 BQ300275 AF077353 CB153716 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DBNL (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ·
    SP1:                          -     -           -                 -                       -     -                 -                                             
    SP2:                          -     -           -                 -                       -     -                                                               
    SP3:                          -     -           -                 -                       -     -                 -                                             
    SP4:                                                              -                                               -                                             
    SP5:                                -           -                 -                       -     -                                                               

    ExUns: 13c · 13d · 13e
    SP1:                  
    SP2:                  
    SP3:                  
    SP4:                  
    SP5:                  


    ECgene alternative splicing isoforms for DBNL

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DBNL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCCTCCACG
    DBNL Expression
    About this image


    DBNL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Lung (Respiratory System)
     
     Esophagus (Gastrointestinal Tract)
    DBNL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DBNL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436500
        Custom PCR Arrays for DBNL
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DBNL
    OriGene qSTAR qPCR primer pairs in human, mouse for DBNL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBNL
    QuantiTect SYBR Green Assays in human, mouse, rat DBNL
    QuantiFast Probe-based Assays in human, mouse, rat DBNL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBNL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DBNL gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dbnl1 , 5 drebrin-like1, 5 84.06(n)1
    86.37(a)1
      11 (3.87 cM)5
    131691  NM_001146308.11  NP_001139780.11 
     57884885 
    chicken
    (Gallus gallus)
    Aves DBNL1 drebrin-like 73.27(n)
    70.56(a)
      425994  XM_423673.4  XP_423673.3 
    lizard
    (Anolis carolinensis)
    Reptilia DBNL6
    drebrin-like
    61(a)
    1 ↔ 1
    GL343238.1(166229-185991)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044296.12   -- 78(n)    BC044296.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb34f022 Transcribed sequence with weak similarity to protein more 76.99(n)    57040107 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100831 CG10083 58.24(n)
    48.66(a)
      39520  NM_140400.2  NP_648657.1 
    worm
    (Caenorhabditis elegans)
    Secernentea K08E3.41 K08E3.4 49.89(n)
    40(a)
      176813  NM_067439.4  NP_499840.1 


    ENSEMBL Gene Tree for DBNL (if available)
    TreeFam Gene Tree for DBNL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DBNL gene
    DBN12  HCLS12  CTTN2  
    6 SIMAP similar genes for DBNL using alignment to 15 protein entries:     DBNL_HUMAN (see all proteins):
    DBN1    SH3GL1    SH3GL2    ARHGEF7    HCLS1    CTTN

    Find genes that share paralogs with DBNL           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DBNL (see all 422)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1134302371,2
    C--44084421(+) ACTGGG/TGGGCG 3 -- spd10--------
    rs1117115901,2
    C--44084422(+) CTGGTC/GGGCGG 3 -- int10--------
    rs69443861,2
    C,F--44084486(+) GCGAGC/TGGGGG 3 -- int15Minor allele frequency- T:0.15CSA WA NA EA 362
    rs69645991,2
    C,F,A--44084526(+) AGCGGT/CGCCCA 3 -- int15Minor allele frequency- C:0.15CSA WA NA EA 362
    rs1916493201,2
    --44084608(+) CCTTGC/TCCCGC 3 -- int10--------
    rs1463499431,2
    --44084747(+) GCTTCG/TCCAGG 3 -- int10--------
    rs117634681,2
    C,H--44084842(+) TTTGCA/GAACGC 3 -- int15Minor allele frequency- G:0.09NA WA EA 362
    rs1396965681,2
    --44084908(+) CCCTGC/GCCTGG 3 -- int10--------
    rs793360041,2
    C,F--44084950(+) TTCTTG/AGCTGT 3 -- int16Minor allele frequency- A:0.15CSA WA NA EA 364
    rs567363161,2
    C,F--44085131(+) TTTACT/CGACCA 3 -- int17Minor allele frequency- C:0.47WA NA EA 366

    HapMap Linkage Disequilibrium report for DBNL (44084239 - 44109055 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DBNL:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv887996CNV Loss21882294
    nsv470210CNV Loss18288195
    nsv830980CNV Loss17160897
    nsv428165CNV Gain18775914
    nsv8082CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DBNL
    DNA2.0 Custom Variant and Variant Library Synthesis for DBNL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610106    OMIM disorders: --


    Find genes that share disorders with DBNL           About GenesLikeMe


    Export disorders for DBNL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DBNL gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with DBNL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis. (PubMed id 11689006)1, 2, 9 Chen Y.-R.... Tan T.-H. (Biochem. Biophys. Res. Commun. 2001)
    2. Recruitment of the actin-binding protein HIP-55 to the immunological synapse regulates T cell receptor signaling and endocytosis. (PubMed id 14729663)1, 2, 9 Le Bras S....Deckert M. (J. Biol. Chem. 2004)
    3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    6. PRAM-1 potentiates arsenic trioxide-induced JNK activation. (PubMed id 15637062)1, 2 Denis F.M.... Lutz P.G. (J. Biol. Chem. 2005)
    7. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    8. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PubMed id 15144186)1, 2 Brill L.M....Peters E.C. (Anal. Chem. 2004)
    9. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 28988 HGNC: 2696 AceView: DBNL Ensembl:ENSG00000136279 euGenes: HUgn28988
    ECgene: DBNL H-InvDB: DBNL

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DBNL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DBNL gene:
    Search GeneIP for patents involving DBNL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DBNL   OriGene RNAi products in human, mouse, rat for DBNL  
     OriGene qPCR primer pairs and template standards for DBNL   OriGene Protein Over-expression Lysate for DBNL  
     OriGene MassSpec something-or-other for DBNL   OriGene clones in human, mouse for DBNL  
     OriGene qSTAR qPCR primer pairs in human, mouse for DBNL   OriGene Purified Protein for DBNL  
     OriGene ORF clones in mouse, rat for DBNL   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DBNL   OriGene Custom Protein Services for DBNL  

     
     
     Block miRNA regulation of human, mouse, rat DBNL using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DBNL
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DBNL Predesigned siRNA for gene silencing in human, mouse, rat DBNL
     QuantiFast Probe-based Assays in human, mouse, rat DBNL QuantiTect SYBR Green Assays in human, mouse, rat DBNL
     Custom PCR Arrays for DBNL Search Chromatin IP Primers for DBNL
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBNL  GeneGlobe Interaction Network for DBNL
     Regulatory tfbs in DBNL promoter
     GenScript Custom Purified and Recombinant Proteins Services for DBNL GenScript cDNA clones with any tag delivered in your preferred vector for DBNL
     GenScript Custom Assay Services for DBNL GenScript Custom overexpressing Cell Line Services for DBNL
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DBNL
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DBNL
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DBNL antibodies
     DBNL proteins
     DBNL lysates
     Antibodies for DBNL
     See all of Abcam's Antibodies, Kits and Proteins for DBNL
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DBNL
     Antibodies for DBNL
     ELISAs for DBNL
     CLIAs for DBNL



     Browse ESI BIO Cell Lines and PureStem Progenitors for DBNL
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBNL
     SwitchGear 3'UTR luciferase reporter plasmids for DBNL
     SwitchGear Promoter luciferase reporter plasmids for DBNL
     ThermoFisher Antibodies for DBNL
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBNL
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DBNL
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DBNL
     LSBio Antibodies in human, mouse, rat for DBNL
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DBNL
      Search eBioscience for proteins for DBNL
      Search eBioscience for elisas for DBNL
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DBNL gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4