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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DBNDD2 Gene

protein-coding   GIFtS: 43
GCID: GC20P044034

Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing...

(Previous name: chromosome 20 open reading frame 35)
(Previous symbol: C20orf35)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 21 2     CK1BP2 3
C20orf351 2 3     Chromosome 20 Open Reading Frame 351
HSMNP12 3 5     Dysbindin Domain-Containing Protein 22
Casein Kinase-1 Binding Protein2 3     SCF Apoptosis Response Protein 12

External Ids:    HGNC: 158811   Entrez Gene: 558612   Ensembl: ENSG000002442747   OMIM: 6114535   UniProtKB: Q9BQY93   

Export aliases for DBNDD2 gene to outside databases

Previous GC identifers: GC20P043426 GC20P043468 GC20P040776


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DBNDD2 Gene: 
DBNDD2 (dysbindin (dystrobrevin binding protein 1) domain containing 2) is a protein-coding gene. Diseases associated with DBNDD2 include intrahepatic cholangiocarcinoma, and cholangiocarcinoma. GO annotations related to this gene include protein binding. An important paralog of this gene is DTNBP1.

UniProtKB/Swiss-Prot: DBND2_HUMAN, Q9BQY9
Function: May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro)

Gene Wiki entry for DBNDD2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NT_011362.10  NC_018931.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DBNDD2 gene promoter:
         CRE-BP1   ATF-2   Lmo2   Nkx2-5   STAT5A   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DBNDD2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DBNDD2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

DBNDD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBNDD2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P044034:  view genomic region     (about GC identifiers)

Start:
44,034,633 bp from pter      End:
44,039,250 bp from pter
Size:
4,618 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DBND2_HUMAN, Q9BQY9 (See protein sequence)
Recommended Name: Dysbindin domain-containing protein 2  
Size: 259 amino acids; 27671 Da
Subunit: Monomer. Interacts with CSNK1D and CSNK1E
Secondary accessions: Q331S6 Q5QPV4 Q5QPV6 Q9BQZ0 Q9BVL1 Q9H1F6 Q9NWZ0 Q9NY07 Q9NZ31
Alternative splicing: 4 isoforms:  Q9BQY9-1   Q9BQY9-2   Q9BQY9-3   Q9BQY9-4   

Explore the universe of human proteins at neXtProt for DBNDD2: NX_Q9BQY9

Explore proteomics data for DBNDD2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BQY9

  • DBNDD2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DBNDD2 Protein Expression
    REFSEQ proteins (9 alternative transcripts): 
    NP_001041686.1  NP_001041687.1  NP_001041688.1  NP_001041689.1  NP_001041690.2  NP_001041691.2  NP_001184068.1  NP_001184069.1  
    NP_060948.3  

    ENSEMBL proteins: 
     ENSP00000361808   ENSP00000361807   ENSP00000349822   ENSP00000361805   ENSP00000361802  
     ENSP00000354250   ENSP00000361797   ENSP00000361795   ENSP00000414161  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    DBNDD2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR007531 Dysbindin

    Graphical View of Domain Structure for InterPro Entry Q9BQY9

    ProtoNet protein and cluster: Q9BQY9

    UniProtKB/Swiss-Prot: DBND2_HUMAN, Q9BQY9
    Similarity: Belongs to the dysbindin family


    DBNDD2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DBND2_HUMAN, Q9BQY9
    Function: May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16618118
         
    DBNDD2 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DBNDD2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DBNDD2 (Q9BQY92, 3 ENSP000003498224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CALCOCO2Q131372, 3, ENSP000002589474MINT-67062 I2D: score=3 STRING: ENSP00000258947
    PLEKHA5Q9HAU03I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006469negative regulation of protein kinase activity IDA16618118

    DBNDD2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DBNDD2 (DBND2)

    Search CenterWatch for drugs/clinical trials and news about DBNDD2 / DBND2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DBNDD2 gene (9 alternative transcripts): 
    NM_001048221.2  NM_001048222.2  NM_001048223.2  NM_001048224.2  NM_001048225.2  NM_001048226.2  NM_001197139.1  NM_001197140.1  
    NM_018478.3  

    Unigene Cluster for DBNDD2:

    Dysbindin (dystrobrevin binding protein 1) domain containing 2
    Hs.730643  [show with all ESTs]
    Unigene Representative Sequence: AK098015
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000372723(uc002xnz.3) ENST00000372722(uc002xoa.3) ENST00000357275(uc021wei.1 uc021wej.1)
    ENST00000372720(uc002xob.3) ENST00000372717(uc002xoc.3 uc002xod.3)
    ENST00000360981 ENST00000372712 ENST00000372710(uc002xog.3 uc002xof.3)
    ENST00000443296

    miRNA
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    hsa-miR-24-2* hsa-miR-374b* hsa-miR-214 hsa-miR-24-1* hsa-miR-2276 hsa-miR-622 hsa-miR-761
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Additional mRNA sequence: 

    AF220191.1 AJ276469.1 AK000531.1 AK098015.1 AL591565.1 AY113697.1 BC001105.2 BC012818.2 
    NR_003189.2 

    18 DOTS entries:

    DT.100810477  DT.100697234  DT.444894  DT.95364384  DT.120830931  DT.100030231  DT.91756231  DT.100810474 
    DT.95364385  DT.91756220  DT.95316815  DT.97783053  DT.91756228  DT.95364387  DT.97855931  DT.101972588 
    DT.120830963  DT.86839111 

    24/656 AceView cDNA sequences (see all 656):

    AI671046 AA939149 CR625786 BM845210 BM695969 AI640210 CR616955 CR618022 
    CR607560 BI916701 CR595212 CN485088 AI638834 BF128637 BI819820 AI741119 
    BU508479 AI050858 BE301313 BU733851 CA503318 AI149677 CR605916 BM763158 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DBNDD2 expression in normal human tissues (normalized intensities)      DBNDD2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGCCTCCTT
    DBNDD2 Expression
    About this image


    DBNDD2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             Caudate nucleus   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Heart (Cardiovascular System)
     
     Spinal Cord (Nervous System)

    See DBNDD2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DBNDD2

    SOURCE GeneReport for Unigene cluster: Hs.730643

    UniProtKB/Swiss-Prot: DBND2_HUMAN, Q9BQY9
    Tissue specificity: Detected in brain

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DBNDD2 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dbndd21 , 5 dysbindin (dystrobrevin binding protein 1) domain containing more1, 5 84.39(n)1
    85.44(a)1
      2 (85.17 cM)5
    528401  NM_026797.21  NP_081073.11 
     1644861065 
    chicken
    (Gallus gallus)
    Aves DBNDD21 dysbindin (dystrobrevin binding protein 1) domain containing more 60.65(n)
    52.9(a)
      419180  XM_417359.3  XP_417359.2 
    lizard
    (Anolis carolinensis)
    Reptilia DBNDD26
    Uncharacterized protein
    38(a)
    1 ↔ 1
    GL343291.1(1604228-1615168)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC536352 similar to chromosome 20 open reading frame 169 73.25(n)    BC041757.1 
    zebrafish
    (Danio rerio)
    Actinopterygii --
    --
    30(a)
    possible ortholog
    11(7127817-7165162)
    fruit fly
    (Drosophila melanogaster)
    Insecta dysb6
    dysbindin
    8(a)
    1 → many
    3L(18860871-18862319)
    corn
    (Zea mays)
    Liliopsida Zm.175242 Zea mays transcribed sequence with weak similarity more 74.94(n)    CD448014.1 


    ENSEMBL Gene Tree for DBNDD2 (if available)
    TreeFam Gene Tree for DBNDD2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DBNDD2 gene
    DTNBP12  
    1 SIMAP similar gene for DBNDD2 using alignment to 2 protein entries:     DBND2_HUMAN (see all proteins):
    DTNBP1

    DBNDD2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DBNDD2
    DNA2.0 Custom Variant and Variant Library Synthesis for DBNDD2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611453    OMIM disorders: --

    4 diseases for DBNDD2:    About MalaCards
    intrahepatic cholangiocarcinoma    cholangiocarcinoma    parkinson's disease    gastric cancer


    DBNDD2 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Export disorders for DBNDD2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DBNDD2 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with DBNDD2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1. (PubMed id 16618118)1, 2 Yin H.... Kuret J. (2006)
    2. The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12. (PubMed id 16305340)1, 2 Lucas T.... Jansen B. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    7. Identification of genes related to Parkinson's disease using expressed sequence tags. (PubMed id 17213182)1 Kim J.M....Kim N.S. (2006)
    8. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
    9. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    10. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55861 HGNC: 15881 AceView: C20orf35 Ensembl:ENSG00000244274 euGenes: HUgn55861
    ECgene: DBNDD2 H-InvDB: DBNDD2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DBNDD2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DBNDD2 gene:
    Search GeneIP for patents involving DBNDD2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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