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DBNDD2 Gene

protein-coding   GIFtS: 44

GC20P043468
dysbindin (dystrobrevin binding protein 1) domain containing 2
(Previous name: chromosome 20 open reading frame 35 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C20orf35)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
C20orf35 2, 3
CK1BP 2
HSMNP1 1, 2, 3, 5
OTTHUMP00000031115 2
OTTHUMP00000031116 2
OTTHUMP00000031117 2
OTTHUMP00000031118 2
OTTHUMP00000031119 2
OTTHUMP00000031120 2
Descriptions
SCF apoptosis response protein 1 2
casein kinase-1 binding protein 2
chromosome 20 open reading frame 35 1
dysbindin (dystrobrevin binding protein 1) domain
containing 2 2
External Ids
HGNC: 158811
Entrez Gene: 558612
UniProtKB: Q9BQY93
Ensembl: ENSG000002040707
Search outside databases for aliases for DBNDD2 gene

Previous GC identifer: GC20P043426

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for DBNDD2
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DBNDD2 gene  

Entrez Gene cytogenetic band: 20q13.12   Ensembl cytogenetic band:  20q13.12   HGNC cytogenetic band: 20q13.12

DBNDD2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P043468:     (about GC identifiers)

Start:
43,468,085 bp from pter
End:
43,472,664 bp from pter
Size:
4,580 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000020.9  NT_011362.9  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DBND2_HUMAN, Q9BQY9 (See protein sequence)
Recommended Name: Dysbindin domain-containing protein 2  
Size: 261 amino acids; 27856 Da
Secondary accessions: Q9BQZ0 Q9BVL1 Q9H1F6 Q9NWZ0 Q9NY07 Q9NZ31
Alternative splicing: 2 isoforms:  Q9BQY9-1   Q9BQY9-2   

REFSEQ proteins (6 alternative transcripts): 
NP_001041686.1  NP_001041687.1  NP_001041688.1  NP_001041689.1  NP_001041690.1  NP_001041691.1  


ENSEMBL proteins: 
ENSP00000361802 ENSP00000361807 ENSP00000361797 ENSP00000354250 ENSP00000349822 ENSP00000361808 
ENSP00000361795 ENSP00000361805 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (C20orf35)
              OriGene Purified Recombinant Human Protein: DBNDD2 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
About this table

Antibodies for DBNDD2: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
Browse Abnova for Monoclonal and Polyclonal Antibodies
Search Novus for antibodies for DBNDD2

Assays for DBNDD2: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

1 InterPro domain/family:
 IPR007531 Dysbindin


   GeneDecks  DBNDD2 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9BQY9

ProtoNet protein and cluster: Q9BQY9

UniProtKB/Swiss-Prot: DBND2_HUMAN, Q9BQY9
Similarity: Belongs to the dysbindin family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (DBNDD2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_001048221

              Applied Biosystems Silencer® siRNAs for DBNDD2

              Sigma-Aldrich siRNA for DBNDD2  
                     Sigma-Aldrich shRNA for DBNDD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for DBNDD2
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001048221
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001048221
                                 untagged cDNA clones in CMV expression vector (see all 7): AL591714 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_001048225

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



1 Interacting protein for DBNDD2 (Q9BQY92) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
CALCOCO2Q131372MINT-67062
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DBNDD2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (DBNDD2)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 7): NM_001048221

              Sigma-Aldrich siRNA for DBNDD2  
                     Sigma-Aldrich shRNA for DBNDD2  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001048221  NM_001048222  NM_001048223  NM_001048224  NM_001048225  NM_001048226  

REFSEQ mRNAs for DBNDD2 gene (6 alternative transcripts): 

NM_001048221.1   NM_001048222.1   NM_001048223.1   NM_001048224.1   NM_001048225.1   NM_001048226.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001048222  NM_001048223  NM_001048224  NM_001048226  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_001048221
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_001048221
                                 untagged cDNA clones in CMV expression vector (see all 7): AL591714 

Additional cDNA sequence: 

AF220191.1 AJ276469.1 AK000531.1 AK075264.1 AK172738.1 AK309429.1 AL591565.1 AL591714.1 
AY113697.1 BC001105.2 BC012818.2 BC048286.1 CR595212.1 CR596680.1 CR599811.1 CR600511.1 
CR604473.1 CR605916.1 CR607560.1 CR610357.1 CR616955.1 CR618022.1 CR618346.1 CR622797.1 
CR623013.1 CR623457.1 CR624106.1 CR625786.1 

24/33 DOTS entries (see all 33 ):

DT.415832  DT.97853151  DT.100810477  DT.100697234  DT.444894  DT.100030231  DT.95364384  DT.120830931 
DT.91756231  DT.100810474  DT.120830980  DT.99931902  DT.120830883  DT.95364385  DT.91756220  DT.95316815 
DT.100797177  DT.100797182  DT.102832295  DT.91756228  DT.120830958  DT.92435658  DT.95364387  DT.97855931 

24/656 AceView cDNA sequences (see all 656 ):

BI758096 AL532475 BM761997 BI822128 BU527390 CR600511 AI540683 BQ011749 
CR604473 BP336561 BI518572 CR622797 BM505581 CR596680 BU556476 AA977070 
CA503318 AW341688 AA584422 BU729212 AA737834 AI149677 F04287 BU733851 

highest scoring ESTs for DBNDD2:

AI928870 AA043132 AA199636 AA324861 AA425399 AA425509 AA425852 AA458887 AA459078 AA478016 

Unigene Cluster for DBNDD2:

Dysbindin (dystrobrevin binding protein 1) domain containing 2
Hs.655055  [show with all ESTs]
Unigene Representative Sequence: NM_033542


GeneLoc Exon Structure

8 Ensembl transcripts including schematic representations:
ENST00000372717  ENST00000372722  ENST00000372712  ENST00000360981  ENST00000357275  ENST00000372723  
ENST00000372710  ENST00000372720  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DBNDD2 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for DBNDD2

1 / 2 / 3

3 probe-sets matching DBNDD2 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

57241_at2, 3 U95-B 2 1.00 0.50 1.00 1.00 AI928870 1.00 0.90 0.95 1

218094_s_at2, 3 U133-A 2 1.00 0.50 -- -- NM_018478 0.40 1.00 0.76 1

218094_s_at2 U133Plus2 2 1.00 0.50 -- -- -- -- -- -- --
About this table
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.655055
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for DBNDD2 gene from 5/9 species (see all 9 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
DBNDD21   -- dysbindin (dystrobrevin binding protein 1) domain containing more 88.47(n)
88.68(a)
477243  XM_534435.2  XP_534435.1 
chimpanzee
(Pan troglodytes)
DBNDD21   -- dysbindin (dystrobrevin binding protein 1) domain containing more 98.96(n)
98.14(a)
458281  XM_514676.2  XP_514676.2 
cow
(Bos taurus)
DBNDD21   -- dysbindin (dystrobrevin binding protein 1) domain containing more 85.62(n)
87.5(a)
507590  XM_584231.3  XP_584231.3 
rat
(Rattus norvegicus)
RGD13116421   -- similar to uncharacterized hypothalamus protein HSMNP1 84.39(n)
87.34(a)
499941  XM_575284.2  XP_575284.2 
mouse
(Mus musculus)
Dbndd21, 5 2 (93.00 cM)5
dysbindin (dystrobrevin binding protein 1) domain containing more1, 5 84.39(n)1
85.44(a)1
528401  NM_026797.21  NP_081073.11 
 AI4150185  AI8447285  (see all 20)
About this table        Species with no ortholog for DBNDD2

ENSEMBL Gene Tree for DBNDD2
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for DBNDD2 gene
DTNBP12  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


8 NCBI SNPs in DBNDD2 are shown
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 20 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
--
rs27432741,2
--43472850(+) tcataG/Tagttt 6 -- ng310--------
--
rs588397331,2
--43472699(+) ATCAA-/ACCCAC 6 -- ng310--------
--
rs124809121,2
--43466284(+) gggctG/Taaatt 2 -- ng510--------
--
rs616440311,2
--43472695(+) AGATAC/TCAAAC 6 -- ng310--------
--
rs61247051,2
--43472899(+) tcacaA/Gtgtaa 6 -- ng310--------
--
rs27415981,2
--43473155(-) ACCTCA/TGTCAG 6 -- ng310--------
--
rs27432761,2
--43473156(+) TGACAA/GAGGTC 6 -- ng310--------
rs27432471,2
--43466191(+) TAGTTC/TTTAGA 2 -- ng510--------
About this table
The following additional 216 SNP(s) have been found in Applied Biosystems data source:
(Click for Applied Biosystems TaqMan ® Genotyping Assay)


 rs2743446 rs2281017 rs2741428 rs2741644 rs6124702 rs6104137 rs6073721
 rs2743264 rs6032143 rs2743418 rs2743429 rs763919 rs2743419 rs2743440
 rs2741640 rs1548226 rs2741643 rs35279519 rs3177110 rs2231619 rs2741592
 rs2741593 rs6032135 rs2743271 rs2741578 rs2743436 rs2741431 rs2743432
 rs2741436 rs2231618 rs6065808 rs2741430 rs2263760 rs2743260 rs6032144
 rs2741582 rs6130816 rs2743426 rs6104151 rs2741581 rs2741632 rs2743435
 rs6073720 rs2741636 rs2743443 rs6032145 rs2231621 rs2741583 rs1060891
 rs2231609 rs2741580 rs2741413 rs6073726 rs6032136 rs3091685 rs2741579
 rs2741429 rs2743415 rs3827039 rs2741633 rs2743272 rs2743270 rs2664583
 rs2743269 rs2741586 rs1028306 rs2741594 rs3761195 rs6073719 rs1810434
 rs2743253 rs2741577 rs2741650 rs2743417 rs2249728 rs2743437 rs2664543
 rs2056938 rs28374281 rs2231613 rs2743438 rs2231627 rs2741625 rs2741624
 rs2743423 rs2231615 rs2743406 rs2741639 rs2741590 rs6032156 rs2245717
 rs2231622 rs2741651 rs2038038 rs2743433 rs2743261 rs2743411 rs6032140
 rs6032139 rs1046612 rs7099 rs2294288 rs2743430 rs2741572 rs2743445
 rs2248637 rs1043974 rs2741418 rs11541733 rs2743229 rs6032138 rs6032171
 rs2741642 rs2741623 rs2743265 rs2741638 rs2741573 rs1127497 rs6032142
 rs760642 rs7265201 rs2743251 rs2741422 rs2741419 rs2231625 rs7264144
 rs2741584 rs2743250 rs2038039 rs2743420 rs2231628 rs7273489 rs2741591
 rs6104150 rs2741646 rs2231616 rs4812893 rs2743267 rs2741420 rs2743414
 rs2741417 rs2743252 rs4812895 rs6017555 rs1028307 rs2743403 rs6032137
 rs2741652 rs760640 rs35320070 rs2743249 rs2743416 rs2743255 rs2247037
 rs2251230 rs6065810 rs2231620 rs2743421 rs6094133 rs6032151 rs2743422
 rs2743439 rs2741616 rs2741426 rs2741571 rs16990058 rs2743428 rs760641
 rs34498991 rs2741637 rs2743425 rs2741424 rs2743427 rs2743434 rs2231617
 rs2741631 rs8123838 rs4812896 rs2903782 rs2252731 rs2256686 rs7098
 rs9653626 rs2741603 rs2741576 rs2741600 rs6032148 rs2741595 rs2741427
 rs7360900 rs2743400 rs7360827 rs2250900 rs2743280 rs2741421 rs2743447
 rs2272806 rs6065811 rs6017556 rs2263759 rs2741414 rs2249094 rs2247619
 rs2741423 rs2741630 rs2741645 rs6032155 rs6032134 rs2743268 rs2231626
 rs2743235 rs2231614 rs2741599 rs707576 rs2743248 rs2231624

HapMap Linkage Disequilibrium images for DBNDD2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 611453

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/14 PubMed articles for DBNDD2 gene (see all 14 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 55861 HGNC: 15881 AceView: C20orf35 Ensembl:ENSG00000204070 euGenes: HUgn55861
ECgene: DBNDD2 H-InvDB: DBNDD2
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for DBNDD2:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for DBNDD2-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for DBNDD2 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for DBNDD2 Browse small molecules at Sigma-Aldrich
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 Search Tocris compounds for DBNDD2




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for DBNDD2

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