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Aliases for DBNDD2 Gene

Aliases for DBNDD2 Gene

  • Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 2 2 3
  • HSMNP1 3 4 6
  • Casein Kinase-1 Binding Protein 3 4
  • C20orf35 3 4
  • CK1BP 3 4
  • Dysbindin Domain-Containing Protein 2 3
  • Chromosome 20 Open Reading Frame 35 2
  • SCF Apoptosis Response Protein 1 3

External Ids for DBNDD2 Gene

Previous Symbols for DBNDD2 Gene

  • C20orf35

Summaries for DBNDD2 Gene

GeneCards Summary for DBNDD2 Gene

DBNDD2 (Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is DTNBP1.

UniProtKB/Swiss-Prot for DBNDD2 Gene

  • May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).

Gene Wiki entry for DBNDD2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBNDD2 Gene

Genomics for DBNDD2 Gene

Genomic Location for DBNDD2 Gene

Start:
45,405,993 bp from pter
End:
45,410,610 bp from pter
Size:
4,618 bases
Orientation:
Plus strand

Genomic View for DBNDD2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DBNDD2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBNDD2 Gene

Regulatory Elements for DBNDD2 Gene

Proteins for DBNDD2 Gene

  • Protein details for DBNDD2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQY9-DBND2_HUMAN
    Recommended name:
    Dysbindin domain-containing protein 2
    Protein Accession:
    Q9BQY9
    Secondary Accessions:
    • Q331S6
    • Q5QPV4
    • Q5QPV6
    • Q9BQZ0
    • Q9BVL1
    • Q9H1F6
    • Q9NWZ0
    • Q9NY07
    • Q9NZ31

    Protein attributes for DBNDD2 Gene

    Size:
    259 amino acids
    Molecular mass:
    27671 Da
    Quaternary structure:
    • Monomer. Interacts with CSNK1D and CSNK1E.

    Alternative splice isoforms for DBNDD2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBNDD2 Gene

Proteomics data for DBNDD2 Gene at MOPED

Post-translational modifications for DBNDD2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DBNDD2 Gene

Domains for DBNDD2 Gene

Protein Domains for DBNDD2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DBND2_HUMAN
Family:
  • Belongs to the dysbindin family.:
    • Q9BQY9
genes like me logo Genes that share domains with DBNDD2: view

No data available for Gene Families for DBNDD2 Gene

Function for DBNDD2 Gene

Molecular function for DBNDD2 Gene

UniProtKB/Swiss-Prot Function: May modulate the activity of casein kinase-1. Inhibits CSNK1D autophosphorylation (in vitro).

Gene Ontology (GO) - Molecular Function for DBNDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16618118
genes like me logo Genes that share ontologies with DBNDD2: view

miRNA for DBNDD2 Gene

miRTarBase miRNAs that target DBNDD2

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DBNDD2 Gene

Localization for DBNDD2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBNDD2 Gene COMPARTMENTS Subcellular localization image for DBNDD2 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for DBNDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DBNDD2: view

Pathways for DBNDD2 Gene

SuperPathways for DBNDD2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DBNDD2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA 16618118
genes like me logo Genes that share ontologies with DBNDD2: view

No data available for Pathways by source for DBNDD2 Gene

Transcripts for DBNDD2 Gene

Unigene Clusters for DBNDD2 Gene

Dysbindin (dystrobrevin binding protein 1) domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DBNDD2 Gene

No ASD Table

Relevant External Links for DBNDD2 Gene

GeneLoc Exon Structure for
DBNDD2
ECgene alternative splicing isoforms for
DBNDD2

Expression for DBNDD2 Gene

mRNA expression in normal human tissues for DBNDD2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBNDD2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.6) and Brain - Substantia nigra (4.4).

SOURCE GeneReport for Unigene cluster for DBNDD2 Gene Hs.730643

mRNA Expression by UniProt/SwissProt for DBNDD2 Gene

Q9BQY9-DBND2_HUMAN
Tissue specificity: Detected in brain.
genes like me logo Genes that share expressions with DBNDD2: view

Orthologs for DBNDD2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DBNDD2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBNDD2 36
  • 98.97 (n)
  • 98.07 (a)
DBNDD2 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DBNDD2 36
  • 85.42 (n)
  • 87.5 (a)
DBNDD2 37
  • 69 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBNDD2 36
  • 88.05 (n)
  • 88.05 (a)
DBNDD2 37
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbndd2 36
  • 80.8 (n)
  • 79.11 (a)
Dbndd2 16
Dbndd2 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DBNDD2 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbndd2 36
  • 80.59 (n)
  • 81.01 (a)
chicken
(Gallus gallus)
Aves DBNDD2 36
  • 60.75 (n)
  • 52.63 (a)
DBNDD2 37
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBNDD2 37
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC53635 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10760 36
zebrafish
(Danio rerio)
Actinopterygii DBNDD2 37
  • 30 (a)
OneToOne
corn
(Zea mays)
Liliopsida Zm.17524 36
Species with no ortholog for DBNDD2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBNDD2 Gene

ENSEMBL:
Gene Tree for DBNDD2 (if available)
TreeFam:
Gene Tree for DBNDD2 (if available)

Paralogs for DBNDD2 Gene

Paralogs for DBNDD2 Gene

Selected SIMAP similar genes for DBNDD2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DBNDD2: view

Variants for DBNDD2 Gene

Relevant External Links for DBNDD2 Gene

HapMap Linkage Disequilibrium report
DBNDD2

No data available for Sequence variations from dbSNP and Humsavar and Structural Variations from Database of Genomic Variants (DGV) for DBNDD2 Gene

Disorders for DBNDD2 Gene

No disorders were found for DBNDD2 Gene.

No data available for UniProtKB/Swiss-Prot for DBNDD2 Gene

Publications for DBNDD2 Gene

  1. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The human orthologue of a novel apoptosis response gene induced during rat myelomonocytic stem cell apoptosis maps to 20q13.12. (PMID: 16305340) Lucas T. … Jansen B. (Stem Cells Dev. 2005) 3 4

Products for DBNDD2 Gene

Sources for DBNDD2 Gene

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