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Aliases for DBNDD1 Gene

Aliases for DBNDD1 Gene

  • Dysbindin Domain Containing 1 2 3 5
  • Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 1 2

External Ids for DBNDD1 Gene

Previous GeneCards Identifiers for DBNDD1 Gene

  • GC16M088599
  • GC16M090071
  • GC16M075763

Summaries for DBNDD1 Gene

GeneCards Summary for DBNDD1 Gene

DBNDD1 (Dysbindin Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBNDD1 Gene

Genomics for DBNDD1 Gene

Regulatory Elements for DBNDD1 Gene

Enhancers for DBNDD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F090018 1.4 FANTOM5 ENCODE 23.4 -1.0 -975 5.3 PKNOX1 CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 FOS DBNDD1 DEF8 PRDM7 GAS8 FAM157C ENSG00000261172 URAHP GAS8-AS1 TUBB3 ENSG00000283182
GH16F089993 1.4 Ensembl ENCODE 19.4 +24.9 24884 3.5 PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 SLC30A9 CBX5 ZNF416 ZNF207 AFG3L1P MC1R ENSG00000259877 SPG7 DBNDD1 GAS8 SNORD68 CDK10 ENSG00000268218 ZNF778
GH16F089439 1.7 FANTOM5 Ensembl ENCODE 14.5 +571.9 571931 17.2 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 SPG7 AFG3L1P RPL13 MC1R LOC101927863 DBNDD1 ENSG00000259877 URAHP ENSG00000268218 ENSG00000260279
GH16F089956 1.6 FANTOM5 Ensembl ENCODE 14.9 +62.4 62360 2.7 ATF1 PKNOX1 ARID4B SIN3A DMAP1 ZNF48 YY1 SLC30A9 ZNF143 FOS DEF8 DBNDD1 CDK10 CENPBD1 GAS8-AS1 ENSG00000261317
GH16F090007 1.1 Ensembl ENCODE 16.5 +11.2 11231 2.2 KLF17 YBX1 ZNF2 RARA GLIS2 ZNF143 KLF7 EGR2 CBFB CEBPB DEF8 DBNDD1 URAHP TUBB3 CENPBD1 VPS9D1-AS1 GAS8 PIR44838
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DBNDD1 on UCSC Golden Path with GeneCards custom track

Promoters for DBNDD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000512437 831 1801 ELF3 ZNF76 KLF17 ARID4B NFXL1 ZNF2 GLIS2 ZNF366 FOS KLF7

Genomic Location for DBNDD1 Gene

Chromosome:
16
Start:
90,004,865 bp from pter
End:
90,020,131 bp from pter
Size:
15,267 bases
Orientation:
Minus strand

Genomic View for DBNDD1 Gene

Genes around DBNDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBNDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBNDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBNDD1 Gene

Proteins for DBNDD1 Gene

  • Protein details for DBNDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9R9-DBND1_HUMAN
    Recommended name:
    Dysbindin domain-containing protein 1
    Protein Accession:
    Q9H9R9
    Secondary Accessions:
    • B4DQS3
    • Q69YT2
    • Q9BW25

    Protein attributes for DBNDD1 Gene

    Size:
    158 amino acids
    Molecular mass:
    17042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DBNDD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBNDD1 Gene

Post-translational modifications for DBNDD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBNDD1 Gene

No data available for DME Specific Peptides for DBNDD1 Gene

Domains & Families for DBNDD1 Gene

Protein Domains for DBNDD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DBNDD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9R9

UniProtKB/Swiss-Prot:

DBND1_HUMAN :
  • Belongs to the dysbindin family.
Family:
  • Belongs to the dysbindin family.
genes like me logo Genes that share domains with DBNDD1: view

No data available for Gene Families for DBNDD1 Gene

Function for DBNDD1 Gene

genes like me logo Genes that share phenotypes with DBNDD1: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DBNDD1 Gene

Localization for DBNDD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBNDD1 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DBNDD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DBNDD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DBNDD1 Gene

Pathways & Interactions for DBNDD1 Gene

SuperPathways for DBNDD1 Gene

No Data Available

Interacting Proteins for DBNDD1 Gene

Gene Ontology (GO) - Biological Process for DBNDD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DBNDD1 Gene

Transcripts for DBNDD1 Gene

Unigene Clusters for DBNDD1 Gene

Dysbindin (dystrobrevin binding protein 1) domain containing 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBNDD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for DBNDD1 Gene

GeneLoc Exon Structure for
DBNDD1
ECgene alternative splicing isoforms for
DBNDD1

Expression for DBNDD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DBNDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBNDD1 Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBNDD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DBNDD1 Gene:

DBNDD1

SOURCE GeneReport for Unigene cluster for DBNDD1 Gene:

Hs.301394
genes like me logo Genes that share expression patterns with DBNDD1: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DBNDD1 Gene

Orthologs for DBNDD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBNDD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBNDD1 34 35
  • 98.08 (n)
dog
(Canis familiaris)
Mammalia DBNDD1 34 35
  • 82.43 (n)
cow
(Bos Taurus)
Mammalia DBNDD1 34 35
  • 79.39 (n)
rat
(Rattus norvegicus)
Mammalia Dbndd1 34
  • 78.18 (n)
mouse
(Mus musculus)
Mammalia Dbndd1 34 16 35
  • 72.84 (n)
oppossum
(Monodelphis domestica)
Mammalia DBNDD1 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBNDD1 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBNDD1 34 35
  • 69.39 (n)
lizard
(Anolis carolinensis)
Reptilia DBNDD1 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbndd1 34
  • 69.23 (n)
zebrafish
(Danio rerio)
Actinopterygii DBNDD1 35
  • 42 (a)
OneToOne
Species where no ortholog for DBNDD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBNDD1 Gene

ENSEMBL:
Gene Tree for DBNDD1 (if available)
TreeFam:
Gene Tree for DBNDD1 (if available)

Paralogs for DBNDD1 Gene

(1) SIMAP similar genes for DBNDD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DBNDD1: view

No data available for Paralogs for DBNDD1 Gene

Variants for DBNDD1 Gene

Sequence variations from dbSNP and Humsavar for DBNDD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs10048106 -- 90,004,405(+) CGGGC(C/T)ACCTT downstream-variant-500B
rs10852628 -- 90,013,519(+) CATGG(C/T)GTGGA intron-variant
rs11076653 -- 90,007,593(+) GGCAA(C/T)GCTCC intron-variant
rs11076654 -- 90,007,677(+) GCCCA(A/T)TTTAT intron-variant
rs11076655 -- 90,013,930(+) TGGGG(C/T)GGGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBNDD1 Gene

Variant ID Type Subtype PubMed ID
esv3448710 CNV duplication 20981092
esv3582452 CNV loss 25503493
esv3639603 CNV gain 21293372
nsv1062080 CNV loss 25217958
nsv1066499 CNV loss 25217958
nsv1070787 CNV deletion 25765185
nsv428331 CNV gain+loss 18775914
nsv457626 CNV loss 19166990
nsv471119 CNV loss 18288195
nsv471120 CNV gain 18288195
nsv482951 CNV loss 15286789
nsv573799 CNV gain 21841781
nsv573810 CNV loss 21841781
nsv573841 CNV loss 21841781
nsv573842 CNV loss 21841781
nsv952080 CNV deletion 24416366
esv3332179 CNV duplication 20981092
esv2762221 CNV gain+loss 21179565
esv26767 CNV gain 19812545
esv1361959 CNV deletion 17803354
esv1095561 CNV deletion 17803354
dgv3067n100 CNV gain 25217958

Variation tolerance for DBNDD1 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBNDD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBNDD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBNDD1 Gene

Disorders for DBNDD1 Gene

Relevant External Links for DBNDD1

Genetic Association Database (GAD)
DBNDD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBNDD1

No disorders were found for DBNDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBNDD1 Gene

Publications for DBNDD1 Gene

  1. Genome-wide association study of tanning phenotype in a population of European ancestry. (PMID: 19340012) Nan H. … Han J. (J. Invest. Dermatol. 2009) 3 46 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y. … Zou H. (J. Proteomics 2014) 4 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for DBNDD1 Gene

Sources for DBNDD1 Gene

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