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DBNDD1 Gene

protein-coding   GIFtS: 41
GCID: GC16M090071

Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing...

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 11 2
Dysbindin Domain-Containing Protein 12

External Ids:    HGNC: 284551   Entrez Gene: 790072   Ensembl: ENSG000000032497   UniProtKB: Q9H9R93   

Export aliases for DBNDD1 gene to outside databases

Previous GC identifers: GC16M088599 GC16M075763


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DBNDD1 Gene:
DBNDD1 (dysbindin (dystrobrevin binding protein 1) domain containing 1) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the DBNDD1 gene promoter:
         GR   SREBP-1a   SREBP-1c   GR-beta   GR-alpha   LCR-F1   SREBP-1b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDBNDD1 promoter sequence
   Search Chromatin IP Primers for DBNDD1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DBNDD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

DBNDD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBNDD1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M090071:  view genomic region     (about GC identifiers)

Start:
90,071,273 bp from pter      End:
90,086,536 bp from pter
Size:
15,264 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DBNDD1

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DBND1_HUMAN, Q9H9R9 (See protein sequence)
Recommended Name: Dysbindin domain-containing protein 1  
Size: 158 amino acids; 17042 Da
Secondary accessions: B4DQS3 Q69YT2 Q9BW25
Alternative splicing: 3 isoforms:  Q9H9R9-1   Q9H9R9-2   Q9H9R9-3   

Explore the universe of human proteins at neXtProt for DBNDD1: NX_Q9H9R9

Explore proteomics data for DBNDD1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DBNDD1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001036075.1  NP_001275637.1  NP_001275638.1  NP_076948.2  

    ENSEMBL proteins: 
     ENSP00000306407   ENSP00000002501   ENSP00000376699   ENSP00000457625   ENSP00000456573  

    DBNDD1 Human Recombinant Protein Products:

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    ProSpec Recombinant Protein for DBNDD1
    Cloud-Clone Corp. Proteins for DBNDD1

     
    Search eBioscience for Proteins for DBNDD1 

     
    antibodies-online proteins for DBNDD1 (7 products) 

     
    Search antibodies-online for peptides for DBNDD1

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    Search antibodies-online for antibodies for DBNDD1 

    DBNDD1 Assay Products:

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    Cloud-Clone Corp. ELISAs for DBNDD1
    Cloud-Clone Corp. CLIAs for DBNDD1
    Search eBioscience for ELISAs for DBNDD1 
    antibodies-online kits for DBNDD1 (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR007531 Dysbindin

    Graphical View of Domain Structure for InterPro Entry Q9H9R9

    ProtoNet protein and cluster: Q9H9R9

    UniProtKB/Swiss-Prot: DBND1_HUMAN, Q9H9R9
    Similarity: Belongs to the dysbindin family


    Find genes that share domains with DBNDD1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DBNDD1

    miRNA
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    Block miRNA regulation of human, mouse, rat DBNDD1 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate DBNDD1:
    hsa-miR-4303 hsa-miR-4252 hsa-miR-4260 hsa-miR-218 hsa-miR-636
    SwitchGear 3'UTR luciferase reporter plasmidDBNDD1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DBNDD1

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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DBNDD1 (NM_001042610)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBNDD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBNDD1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBNDD1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DBNDD1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DBNDD1
    Interactions:

        Search GeneGlobe Interaction Network for DBNDD1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DBNDD1 (DBND1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DBNDD1 gene (4 alternative transcripts): 
    NM_001042610.2  NM_001288708.1  NM_001288709.1  NM_024043.3  

    Unigene Cluster for DBNDD1:

    Dysbindin (dystrobrevin binding protein 1) domain containing 1
    Hs.301394  [show with all ESTs]
    Unigene Representative Sequence: AK096507
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000304733(uc002fqe.1) ENST00000002501(uc002fqf.1 uc002fqg.1)
    ENST00000392973 ENST00000568838 ENST00000568662 ENST00000568330
    miRNA
    Products:
         
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    5 qRT-PCR Assays for microRNAs that regulate DBNDD1:
    hsa-miR-4303 hsa-miR-4252 hsa-miR-4260 hsa-miR-218 hsa-miR-636
    SwitchGear 3'UTR luciferase reporter plasmidDBNDD1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DBNDD1
    Predesigned siRNA for gene silencing in human, mouse, rat DBNDD1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DBNDD1 (NM_001042610)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBNDD1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBNDD1
    Primer
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    OriGene qPCR primer pairs and template standards for DBNDD1
    OriGene qSTAR qPCR primer pairs in human, mouse for DBNDD1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBNDD1
      QuantiTect SYBR Green Assays in human, mouse, rat DBNDD1
      QuantiFast Probe-based Assays in human, mouse, rat DBNDD1

    Additional mRNA sequence: 

    AK022644.1 AK090696.1 AK090965.1 AK096507.1 AK298932.1 AK308737.1 AL713678.1 BC000700.2 

    10 DOTS entries:

    DT.100782491  DT.100782490  DT.214910  DT.120721037  DT.100782494  DT.97759896  DT.92425551  DT.120720949 
    DT.92425552  DT.92425549 

    Selected AceView cDNA sequences (see all 119):

    AA991580 BG113111 AK096507 BI094047 BM715499 CR594535 CD676065 AW630072 
    BQ893562 BC000700 AX746579 AK090696 AL713678 AA806459 AW613841 BM712235 
    NM_024043 AI087811 BF196967 BU183018 BX279734 AA936822 CD676335 BQ898846 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DBNDD1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
    SP1:                                      -                                 
    SP2:        -     -     -     -           -                                 
    SP3:              -     -     -           -                                 
    SP4:                    -     -           -                                 
    SP5:                                      -                                 


    ECgene alternative splicing isoforms for DBNDD1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DBNDD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DBNDD1 Expression
    About this image


    DBNDD1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Mature B-Cells Peripheral Blood
    DBNDD1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DBNDD1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301394
        Custom PCR Arrays for DBNDD1
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBNDD1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DBNDD1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dbndd11 , 5 dysbindin (dystrobrevin binding protein 1) domain containing more1, 5 72.84(n)1
    68.78(a)1
      8 (72.10 cM)5
    721851  NM_028146.41  NP_082422.31 
     1235047185 
    chicken
    (Gallus gallus)
    Aves DBNDD11 dysbindin (dystrobrevin binding protein 1) domain containing more 69.39(n)
    67.35(a)
      415857  XM_001232717.3  XP_001232718.2 
    lizard
    (Anolis carolinensis)
    Reptilia DBNDD16
    dysbindin (dystrobrevin binding protein 1) domain ...
    61(a)
    1 ↔ 1
    GL343866.1(144965-147965)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dbndd11 dysbindin (dystrobrevin binding protein 1) domain containing more 69.23(n)
    76.07(a)
      100486728  XM_002933663.2  XP_002933709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii DBNDD16
    dysbindin (dystrobrevin binding protein 1) domain ...
    42(a)
    1 ↔ 1
    25(38154243-38164768) ENSDARG00000090108


    ENSEMBL Gene Tree for DBNDD1 (if available)
    TreeFam Gene Tree for DBNDD1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DBNDD1 gene
    1 SIMAP similar gene for DBNDD1 using alignment to 3 protein entries:     DBND1_HUMAN (see all proteins):
    MGC3101

    Find genes that share paralogs with DBNDD1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DBNDD1 (see all 496)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs116438531,2
    C,F,A,H--90070808(+) TGGCCT/CGGGCC 2 -- int16Minor allele frequency- C:0.43NA WA 14
    rs100481061,2
    C,F,A,H--90070813(+) CGGGCC/TACCTT 2 -- int14Minor allele frequency- T:0.30NA 10
    rs557172231,2
    C--90070832(+) CGTGGG/AGCGGG 2 -- int11Minor allele frequency- A:0.50WA 2
    rs1135546141,2
    C,F--90070863(+) TGGCCC/TGGGCT 2 -- int12Minor allele frequency- T:0.50NA WA 4
    rs116400641,2
    C,H--90070868(+) CGGGCC/TACCTT 2 -- int10--------
    rs343990751,2
    C--90070889(+) TGGGGC/TGGGAC 2 -- int11Minor allele frequency- T:0.50NA 2
    rs1137831931,2
    C,F--90070901(+) TCTGTG/AACTCC 2 -- int12Minor allele frequency- A:0.50NA WA 4
    rs344319891,2
    C--90070919(+) GGCCCA/GGGCCA 2 -- int12Minor allele frequency- G:0.33NA CSA 3
    rs1132394361,2
    C,F--90070923(+) CAGGCC/TACCTT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1490260971,2
    C--90070945(+) TGGGGC/TGGGAC 2 -- int10--------

    HapMap Linkage Disequilibrium report for DBNDD1 (90071273 - 90086536 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DBNDD1 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1095561CNV Deletion17803354
    esv1361959CNV Deletion17803354
    dgv3009n71CNV Loss21882294
    nsv907445CNV Loss21882294
    nsv907429CNV Loss21882294
    dgv3017n71CNV Loss21882294
    dgv3016n71CNV Loss21882294
    dgv3015n71CNV Loss21882294
    nsv482951CNV Loss15286789
    nsv457626CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DBNDD1
    DNA2.0 Custom Variant and Variant Library Synthesis for DBNDD1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with DBNDD1           About GenesLikeMe

    Genetic Association Database (GAD): DBNDD1

    Export disorders for DBNDD1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DBNDD1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with DBNDD1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association study of tanning phenotype in a population of European ancestry. (PubMed id 19340012)1, 4 Nan H....Han J. (J. Invest. Dermatol. 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Variation in the dysbindin gene and normal cognitive function in three independent population samples. (PubMed id 19077176)1 Luciano M....Payton A. (Genes Brain Behav. 2009)
    5. TRIM32 is an E3 ubiquitin ligase for dysbindin. (PubMed id 19349376)1 Locke M.... Blake D.J. (Hum. Mol. Genet. 2009)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    8. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H.... Kim N.S. (Mamm. Genome 2005)
    9. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (Nature 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 79007 HGNC: 28455 AceView: MGC3101 Ensembl:ENSG00000003249 euGenes: HUgn79007
    ECgene: DBNDD1 H-InvDB: DBNDD1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DBNDD1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DBNDD1 gene:
    Search GeneIP for patents involving DBNDD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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