Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DBNDD1 Gene

Aliases for DBNDD1 Gene

  • Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 1 2 3 5

External Ids for DBNDD1 Gene

Previous GeneCards Identifiers for DBNDD1 Gene

  • GC16M088599
  • GC16M090071
  • GC16M075763

Summaries for DBNDD1 Gene

GeneCards Summary for DBNDD1 Gene

DBNDD1 (Dysbindin (Dystrobrevin Binding Protein 1) Domain Containing 1) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBNDD1 Gene

Genomics for DBNDD1 Gene

Regulatory Elements for DBNDD1 Gene

Enhancers for DBNDD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DBNDD1 on UCSC Golden Path with GeneCards custom track

Promoters for DBNDD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DBNDD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DBNDD1 Gene

Chromosome:
16
Start:
90,004,865 bp from pter
End:
90,020,131 bp from pter
Size:
15,267 bases
Orientation:
Minus strand

Genomic View for DBNDD1 Gene

Genes around DBNDD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBNDD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBNDD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBNDD1 Gene

Proteins for DBNDD1 Gene

  • Protein details for DBNDD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H9R9-DBND1_HUMAN
    Recommended name:
    Dysbindin domain-containing protein 1
    Protein Accession:
    Q9H9R9
    Secondary Accessions:
    • B4DQS3
    • Q69YT2
    • Q9BW25

    Protein attributes for DBNDD1 Gene

    Size:
    158 amino acids
    Molecular mass:
    17042 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DBNDD1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBNDD1 Gene

Proteomics data for DBNDD1 Gene at MOPED

Post-translational modifications for DBNDD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBNDD1 Gene

No data available for DME Specific Peptides for DBNDD1 Gene

Domains & Families for DBNDD1 Gene

Protein Domains for DBNDD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DBNDD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H9R9

UniProtKB/Swiss-Prot:

DBND1_HUMAN :
  • Belongs to the dysbindin family.
Family:
  • Belongs to the dysbindin family.
genes like me logo Genes that share domains with DBNDD1: view

No data available for Gene Families for DBNDD1 Gene

Function for DBNDD1 Gene

genes like me logo Genes that share phenotypes with DBNDD1: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DBNDD1 Gene

Localization for DBNDD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBNDD1 Gene COMPARTMENTS Subcellular localization image for DBNDD1 gene
Compartment Confidence
cytosol 3
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DBNDD1 Gene

Pathways & Interactions for DBNDD1 Gene

SuperPathways for DBNDD1 Gene

No Data Available

Interacting Proteins for DBNDD1 Gene

Gene Ontology (GO) - Biological Process for DBNDD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DBNDD1 Gene

Drugs & Compounds for DBNDD1 Gene

No Compound Related Data Available

Transcripts for DBNDD1 Gene

Unigene Clusters for DBNDD1 Gene

Dysbindin (dystrobrevin binding protein 1) domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DBNDD1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1: -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for DBNDD1 Gene

GeneLoc Exon Structure for
DBNDD1
ECgene alternative splicing isoforms for
DBNDD1

Expression for DBNDD1 Gene

mRNA expression in normal human tissues for DBNDD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBNDD1 Gene

This gene is overexpressed in Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x4.7), and Brain - Anterior cingulate cortex (BA24) (x4.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DBNDD1 Gene



SOURCE GeneReport for Unigene cluster for DBNDD1 Gene Hs.301394

genes like me logo Genes that share expression patterns with DBNDD1: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for DBNDD1 Gene

Orthologs for DBNDD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBNDD1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DBNDD1 35
  • 79.39 (n)
  • 76.32 (a)
DBNDD1 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBNDD1 35
  • 82.43 (n)
  • 83.78 (a)
DBNDD1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbndd1 35
  • 72.84 (n)
  • 68.78 (a)
Dbndd1 16
Dbndd1 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DBNDD1 35
  • 98.08 (n)
  • 94.96 (a)
DBNDD1 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbndd1 35
  • 78.18 (n)
  • 75.76 (a)
oppossum
(Monodelphis domestica)
Mammalia DBNDD1 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBNDD1 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBNDD1 35
  • 69.39 (n)
  • 67.35 (a)
DBNDD1 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBNDD1 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbndd1 35
  • 69.23 (n)
  • 76.07 (a)
zebrafish
(Danio rerio)
Actinopterygii DBNDD1 36
  • 42 (a)
OneToOne
Species with no ortholog for DBNDD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBNDD1 Gene

ENSEMBL:
Gene Tree for DBNDD1 (if available)
TreeFam:
Gene Tree for DBNDD1 (if available)

Paralogs for DBNDD1 Gene

(1) SIMAP similar genes for DBNDD1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DBNDD1: view

No data available for Paralogs for DBNDD1 Gene

Variants for DBNDD1 Gene

Sequence variations from dbSNP and Humsavar for DBNDD1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8062608 -- 90,009,624(+) GAGGC(A/T)GCTCC intron-variant
rs4293384 -- 90,016,424(+) GGCGG(A/G)TGCTG intron-variant
rs4362387 -- 90,008,818(+) TCGTC(C/T)GAGTC reference, synonymous-codon
rs4461072 -- 90,011,253(+) CAGCA(C/G)CTGCC intron-variant, upstream-variant-2KB
rs13331975 -- 90,007,779(+) TGTGA(C/T)GGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBNDD1 Gene

Variant ID Type Subtype PubMed ID
nsv428331 CNV Gain+Loss 18775914
dgv3009n71 CNV Loss 21882294
nsv907429 CNV Loss 21882294
dgv3015n71 CNV Loss 21882294
nsv907445 CNV Loss 21882294
nsv457626 CNV Loss 19166990
nsv471119 CNV Loss 18288195
nsv482951 CNV Loss 15286789
nsv471120 CNV Gain 18288195
dgv3016n71 CNV Loss 21882294
dgv3017n71 CNV Loss 21882294
esv26767 CNV Gain 19812545
esv1095561 CNV Deletion 17803354
esv1361959 CNV Deletion 17803354

Variation tolerance for DBNDD1 Gene

Residual Variation Intolerance Score: 33.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.19; 39.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBNDD1 Gene

HapMap Linkage Disequilibrium report
DBNDD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBNDD1 Gene

Disorders for DBNDD1 Gene

Relevant External Links for DBNDD1

Genetic Association Database (GAD)
DBNDD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBNDD1

No disorders were found for DBNDD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBNDD1 Gene

Publications for DBNDD1 Gene

  1. Genome-wide association study of tanning phenotype in a population of European ancestry. (PMID: 19340012) Nan H. … Han J. (J. Invest. Dermatol. 2009) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Variation in the dysbindin gene and normal cognitive function in three independent population samples. (PMID: 19077176) Luciano M. … Payton A. (Genes Brain Behav. 2009) 3
  4. TRIM32 is an E3 ubiquitin ligase for dysbindin. (PMID: 19349376) Locke M. … Blake D.J. (Hum. Mol. Genet. 2009) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for DBNDD1 Gene

Sources for DBNDD1 Gene

Content