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DBNDD1 Gene

protein-coding   GIFtS: 41

GC16M088599
dysbindin (dystrobrevin binding protein 1) domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for DBNDD1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FLJ12582 1, 2
MGC3101 1, 2
Descriptions
dysbindin (dystrobrevin binding protein 1) domain
containing 1 2
External Ids
HGNC: 284551
Entrez Gene: 790072
UniProtKB: Q9H9R93
Ensembl: ENSG000000032497
Search outside databases for aliases for DBNDD1 gene

Summaries
for DBNDD1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for DBNDD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DBNDD1 gene  

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

DBNDD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M088599:     (about GC identifiers)

Start:
 88,598,780 bp from pter
End:
 88,613,438 bp from pter
Size:
 14,659 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000016.8  NT_010542.15  

Proteins
for DBNDD1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: DBND1_HUMAN, Q9H9R9 (See protein sequence)
Recommended Name: Dysbindin domain-containing protein 1  
Size: 158 amino acids; 17042 Da
Secondary accessions: B4DQS3 Q69YT2 Q9BW25
Alternative splicing: 3 isoforms:  Q9H9R9-1   Q9H9R9-2   Q9H9R9-3   

REFSEQ proteins (2 alternative transcripts): 
NP_001036075.1  NP_076948.2  


ENSEMBL proteins: 
ENSP00000002501 ENSP00000306407 ENSP00000376699 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (MGC3101)
              OriGene Purified Recombinant Human Protein: DBNDD1 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
About this table

Antibodies for DBNDD1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for DBNDD1

Assays for DBNDD1: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for DBNDD1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR007531 Dysbindin


   GeneDecks  DBNDD1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9H9R9

ProtoNet protein and cluster: Q9H9R9

UniProtKB/Swiss-Prot: DBND1_HUMAN, Q9H9R9
Similarity: Belongs to the dysbindin family

Gene Function
for DBNDD1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (DBNDD1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001042610

              Applied Biosystems Silencer® siRNAs for DBNDD1

              Sigma-Aldrich siRNA for DBNDD1  
                     Sigma-Aldrich shRNA for DBNDD1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001042610
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001042610
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001042610 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_024043

1 MGI phenotypic allele for Dbndd1 (no phenotypes)

1 Gene Ontology (GO) molecular function term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IEA--
About this table

Pathways & Interactions
for DBNDD1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


  --

Drugs & Compounds
for DBNDD1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DBNDD1

Transcripts
for DBNDD1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (DBNDD1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001042610

              Sigma-Aldrich siRNA for DBNDD1  
                     Sigma-Aldrich shRNA for DBNDD1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_001042610  NM_024043  

REFSEQ mRNAs for DBNDD1 gene (2 alternative transcripts): 

NM_001042610.1   NM_024043.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_001042610  NM_024043  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001042610
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001042610
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001042610 

Additional cDNA sequence: 

AK022644.1 AK090696.1 AK090965.1 AK096507.1 AK298932.1 AK308737.1 AL713678.1 BC000700.2 
CR594535.1 

10 DOTS entries:

DT.100782491  DT.100782490  DT.214910  DT.100782494  DT.120721037  DT.97759896  DT.120720949  DT.92425551 
DT.92425552  DT.92425549 

24/119 AceView cDNA sequences (see all 119 ):

BQ893562 AK090696 AL713678 CR594535 BC000700 AA991580 AW613841 BG113111 
AI087811 AK096507 BI094047 BM715499 BU183018 AW630072 AX746579 CD676065 
BX279734 AA806459 NM_024043 BM712235 BF196967 AL524473 AA936822 CA313956 

highest scoring ESTs for DBNDD1:

AK022644 AK090696 AK090965 AL558279 AW014575 BC000700 BE254402 BG338979 BI598804 BQ068914 

Unigene Cluster for DBNDD1:

Dysbindin (dystrobrevin binding protein 1) domain containing 1
Hs.301394  [show with all ESTs]
Unigene Representative Sequence: AK096507


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DBNDD1 (see all 6 )

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d
SP1:                                      -                                 
SP2:        -     -     -     -           -                                 
SP3:              -     -     -           -                                 
SP4:                    -     -           -                                 
SP5:                                      -                                 

About this scheme

ECgene alternative splicing isoforms for DBNDD1

3 Ensembl transcripts including schematic representations:
ENST00000002501  ENST00000304733  ENST00000392973  

Expression
for DBNDD1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DBNDD1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for DBNDD1

1 / 2 / 3

3 probe-sets matching DBNDD1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
58379_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AW014575 0.80 1.00 0.91 1

222234_s_at2, 3 U133-A 1 1.00 1.00 -- -- AK022644 0.80 1.00 0.91 1

222234_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  DBNDD1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.301394

Orthologs
for DBNDD1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for DBNDD1 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 DBNDD11   -- dysbindin (dystrobrevin binding protein 1) domain containing more 80(n)
81.87(a)		 489649  XM_546769.2  XP_546769.2 
chimpanzee
(Pan troglodytes)		 DBNDD11   -- dysbindin (dystrobrevin binding protein 1) domain containing more 98.72(n)
96.79(a)		 738515  XM_001144079.1  XP_001144079.1 
cow
(Bos taurus)		 DBNDD11   -- dysbindin (dystrobrevin binding protein 1) domain containing more 79.78(n)
76.67(a)		 518157  XM_596341.3  XP_596341.3 
rat
(Rattus norvegicus)		 Dbndd11   -- dysbindin (dystrobrevin binding protein 1) domain containing more 82.33(n)
81.88(a)		 361437  NM_001014156.1  NP_001014178.1 
mouse
(Mus musculus)		 Dbndd11, 5 8 (67.00 cM)5
 dysbindin (dystrobrevin binding protein 1) domain containing more1, 5 81.56(n)1
80.67(a)1		 721851  NM_028146.21  NP_082422.11 
 AI4154235  AK0131735  (see all 10)
About this table        Species with no ortholog for DBNDD1

ENSEMBL Gene Tree for DBNDD1

Paralogs
for DBNDD1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for DBNDD1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/144 NCBI SNPs in DBNDD1 are shown (see all 144 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 32)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 16 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
--
rs100481061,2
A,C88598314(+) CGGGCC/TACCTT 2 -- ng510--------
rs22410851,2
F,H88599766(-) GAGGCG/AGGTTT 2 -- ut315Minor allele frequency- A:0.06EA EU WA 1918
--
rs116446181,2
A,C88604347(+) tctcgC/Gctcat 2 -- int1 ng310--------
--
rs116438531,2
A,C88598309(+) TGGCCC/TGGGCC 2 -- ng510--------
rs44610721,2
A,C88605162(+) CAGCAC/GCTGCC 2 -- int1 ng310--------
rs118633761,2
C88599009(+) CGGAGA/GGGCAG 2 -- ut310--------
--
rs98888221,2
A88613934(+) GACccC/Gcatgt 1 -- ng310--------
--
rs110766561,2
C88613288(-) GACGCC/GGCCGT 1 -- ut51 ese30--------
--
rs116400641,2
C88598369(+) CGGGCC/TACCTT 2 -- ng510--------
rs43623871,2
C,F,H88602727(+) TCGTCC/TGAGTC 2 S/S syn1 ese34Minor allele frequency- T:0.01EU EA WA 382
About this table

HapMap Linkage Disequilibrium images for DBNDD1 (up to first 250kb)

Disorders & Mutations
for DBNDD1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

   --

Medical News
for DBNDD1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for DBNDD1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

6 PubMed articles for DBNDD1 gene:

Search for DBNDD1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing DBNDD1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 79007 HGNC: 28455 AceView: MGC3101 Ensembl:ENSG00000003249 euGenes: HUgn79007
ECgene: DBNDD1 H-InvDB: DBNDD1

Other Databases showing DBNDD1

(According to HUGE)
About This Section

   --

Specialized Databases showing DBNDD1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for DBNDD1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for DBNDD1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for DBNDD1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for DBNDD1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for DBNDD1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for DBNDD1 Browse small molecules at Sigma-Aldrich
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 Search Novus for antibodies for DBNDD1

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