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Aliases for DBN1 Gene

Aliases for DBN1 Gene

  • Drebrin 1 2 3 5
  • Developmentally-Regulated Brain Protein 3 4
  • D0S117E 3 4
  • Drebrin E2 3
  • Drebrin E 3
  • Drebrin-1 3

External Ids for DBN1 Gene

Previous HGNC Symbols for DBN1 Gene

  • D0S117E

Previous GeneCards Identifiers for DBN1 Gene

  • GC05M177180
  • GC05M177726
  • GC05M176819
  • GC05M176865
  • GC05M176867
  • GC05M176816
  • GC05M176883
  • GC05M171803

Summaries for DBN1 Gene

Entrez Gene Summary for DBN1 Gene

  • The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DBN1 Gene

DBN1 (Drebrin 1) is a Protein Coding gene. Diseases associated with DBN1 include Alzheimer Disease. Among its related pathways are Signaling in Gap Junctions and Neuroscience. GO annotations related to this gene include actin binding and profilin binding. An important paralog of this gene is CTTN.

UniProtKB/Swiss-Prot for DBN1 Gene

  • Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.

Gene Wiki entry for DBN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBN1 Gene

Genomics for DBN1 Gene

Regulatory Elements for DBN1 Gene

Enhancers for DBN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DBN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DBN1 Gene

Chromosome:
5
Start:
177,456,608 bp from pter
End:
177,480,336 bp from pter
Size:
23,729 bases
Orientation:
Minus strand

Genomic View for DBN1 Gene

Genes around DBN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBN1 Gene

Proteins for DBN1 Gene

  • Protein details for DBN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16643-DREB_HUMAN
    Recommended name:
    Drebrin
    Protein Accession:
    Q16643
    Secondary Accessions:
    • A8MV58
    • B2RBG0
    • Q9UFZ5

    Protein attributes for DBN1 Gene

    Size:
    649 amino acids
    Molecular mass:
    71429 Da
    Quaternary structure:
    • Interacts with RUFY3 (By similarity). Binds F-actin. Interacts with CXCR4; this interaction is enhanced by antigenic stimulation (PubMed:20215400).

    Alternative splice isoforms for DBN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBN1 Gene

Proteomics data for DBN1 Gene at MOPED

Post-translational modifications for DBN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DBN1 (DBN1)

No data available for DME Specific Peptides for DBN1 Gene

Domains & Families for DBN1 Gene

Protein Domains for DBN1 Gene

Suggested Antigen Peptide Sequences for DBN1 Gene

Graphical View of Domain Structure for InterPro Entry

Q16643

UniProtKB/Swiss-Prot:

DREB_HUMAN :
  • Contains 1 ADF-H domain.
Domain:
  • Contains 1 ADF-H domain.
genes like me logo Genes that share domains with DBN1: view

No data available for Gene Families for DBN1 Gene

Function for DBN1 Gene

Molecular function for DBN1 Gene

GENATLAS Biochemistry:
drebrin,actin binding protein involved in neuronal growth,developmentally regulated,embryonic isoforms E1,E2
UniProtKB/Swiss-Prot Function:
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites. Required for actin polymerization at immunological synapses (IS) and for CXCR4 recruitment to IS.
genes like me logo Genes that share phenotypes with DBN1: view

Animal Models for DBN1 Gene

MGI Knock Outs for DBN1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBN1 Gene

Localization for DBN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBN1 Gene

Cytoplasm. Cytoplasm, cell cortex. Cell junction. Cell projection. Cell projection, growth cone. Note=In the absence of antigen, evenly distributed throughout subcortical regions of the T-cell membrane and cytoplasm. In the presence of antigen, distributes to the immunological synapse forming at the T cell-APC contact area, where it localizes at the peripheral and distal supramolecular activation clusters (SMAC) (PubMed:20215400). Colocalized with DBN1, RUFY3 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250 UniProtKB:Q9QXS6, ECO:0000269 PubMed:20215400}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBN1 Gene COMPARTMENTS Subcellular localization image for DBN1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for DBN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane IDA --
GO:0005921 gap junction IEA --
GO:0030425 dendrite NAS 12009525
GO:0030426 growth cone ISS --
genes like me logo Genes that share ontologies with DBN1: view

Pathways & Interactions for DBN1 Gene

genes like me logo Genes that share pathways with DBN1: view

Pathways by source for DBN1 Gene

2 Cell Signaling Technology pathways for DBN1 Gene
1 Qiagen pathway for DBN1 Gene

Gene Ontology (GO) - Biological Process for DBN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010644 cell communication by electrical coupling IEA --
GO:0032507 maintenance of protein location in cell IEA --
GO:0048168 regulation of neuronal synaptic plasticity NAS 12009525
GO:0050773 regulation of dendrite development NAS 12009525
genes like me logo Genes that share ontologies with DBN1: view

No data available for SIGNOR curated interactions for DBN1 Gene

Drugs & Compounds for DBN1 Gene

(2) Drugs for DBN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for DBN1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DBN1: view

Transcripts for DBN1 Gene

Unigene Clusters for DBN1 Gene

Drebrin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DBN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
SP1: - - -
SP2: - - - - -
SP3: - - - - -
SP4: -
SP5:
SP6: - -

Relevant External Links for DBN1 Gene

GeneLoc Exon Structure for
DBN1
ECgene alternative splicing isoforms for
DBN1

Expression for DBN1 Gene

mRNA expression in normal human tissues for DBN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DBN1 Gene

This gene is overexpressed in Fetal Brain (18.5), Bone marrow mesenchymal stem cell (10.8), and Bone marrow stromal cell (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DBN1 Gene



SOURCE GeneReport for Unigene cluster for DBN1 Gene Hs.130316

mRNA Expression by UniProt/SwissProt for DBN1 Gene

Q16643-DREB_HUMAN
Tissue specificity: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas. Expressed in peripheral blood lymphocytes, including T-cells (at protein level).
genes like me logo Genes that share expression patterns with DBN1: view

Protein tissue co-expression partners for DBN1 Gene

Primer Products

No data available for mRNA differential expression in normal tissues for DBN1 Gene

Orthologs for DBN1 Gene

This gene was present in the common ancestor of animals.

Orthologs for DBN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DBN1 35
  • 88.94 (n)
  • 91.71 (a)
DBN1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBN1 35
  • 88.59 (n)
  • 91.86 (a)
DBN1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbn1 35
  • 85.63 (n)
  • 88.24 (a)
Dbn1 16
Dbn1 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DBN1 35
  • 99.41 (n)
  • 99.03 (a)
DBN1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbn1 35
  • 85.42 (n)
  • 88.71 (a)
oppossum
(Monodelphis domestica)
Mammalia DBN1 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 17 (a)
ManyToMany
chicken
(Gallus gallus)
Aves DBN1 35
  • 70.88 (n)
  • 68.17 (a)
DBN1 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBN1 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dbn1 35
  • 63.2 (n)
  • 61.58 (a)
Str.17297 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24319 35
zebrafish
(Danio rerio)
Actinopterygii LOC561153 35
  • 64.72 (n)
  • 62 (a)
dbn1 36
  • 49 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG10083 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea K08E3.4 36
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3471 36
  • 23 (a)
OneToMany
Species with no ortholog for DBN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DBN1 Gene

ENSEMBL:
Gene Tree for DBN1 (if available)
TreeFam:
Gene Tree for DBN1 (if available)

Paralogs for DBN1 Gene

Paralogs for DBN1 Gene

(1) SIMAP similar genes for DBN1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with DBN1: view

Variants for DBN1 Gene

Sequence variations from dbSNP and Humsavar for DBN1 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
VAR_035910 A breast cancer sample
VAR_035911 A breast cancer sample
rs2544809 - 177,458,498(+) GTGGA(C/T)CTCCG reference, missense
rs28538572 - 177,458,177(+) CAGGG(A/C/G)CTCCC reference, missense
rs834572 -- 177,464,122(-) tttat(C/T)ttttt intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DBN1 Gene

Variant ID Type Subtype PubMed ID
dgv6379n71 CNV Loss 21882294
nsv471057 CNV Loss 18288195
nsv883163 CNV Loss 21882294
nsv883164 CNV Loss 21882294
dgv733n27 CNV Loss 19166990
dgv6381n71 CNV Loss 21882294
nsv883172 CNV Loss 21882294
dgv6383n71 CNV Loss 21882294
nsv515805 CNV Loss 19592680
nsv883177 CNV Loss 21882294
nsv883178 CNV Loss 21882294
dgv1010e201 CNV Deletion 23290073
esv2731196 CNV Deletion 23290073
nsv329790 CNV Loss 16902084
esv1004774 CNV Deletion 20482838
esv2731198 CNV Deletion 23290073

Variation tolerance for DBN1 Gene

Residual Variation Intolerance Score: 13.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.69; 73.02% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DBN1 Gene

Disorders for DBN1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DBN1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
alzheimer disease
  • alzheimer disease, late-onset
- elite association - COSMIC cancer census association via MalaCards
Search DBN1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DBN1

Genetic Association Database (GAD)
DBN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBN1
genes like me logo Genes that share disorders with DBN1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DBN1 Gene

Publications for DBN1 Gene

  1. Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene. (PMID: 8216329) Toda M. … Uyemura K. (Biochem. Biophys. Res. Commun. 1993) 2 3 4 23 67
  2. Control of cell shape and plasticity during development and disease by the actin-binding protein Drebrin. (PMID: 20183806) Dun X.P. … Chilton J.K. (Histol. Histopathol. 2010) 3 23
  3. F-actin-binding protein drebrin regulates CXCR4 recruitment to the immune synapse. (PMID: 20215400) PAcrez-MartA-nez M. … SA!nchez-Madrid F. (J. Cell. Sci. 2010) 3 23
  4. Decreased drebrin mRNA expression in Alzheimer disease: correlation with tau pathology. (PMID: 18338803) Julien C. … Calon F. (J. Neurosci. Res. 2008) 3 23
  5. Targeting of the F-actin-binding protein drebrin by the microtubule plus-tip protein EB3 is required for neuritogenesis. (PMID: 18806788) Geraldo S. … Gordon-Weeks P.R. (Nat. Cell Biol. 2008) 3 23

Products for DBN1 Gene

Sources for DBN1 Gene

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