DBN1 Gene

Aliases
for DBN1 gene

Previous GC identifers: GC05M177180 GC05M177726 GC05M176819 GC05M176865 GC05M176867 GC05M176816 GC05M171803

Summaries
for DBN1 gene

Genomic Views
for DBN1 gene

RefSeq DNA sequence:

NC_000005.9  NC_018916.1  NT_023133.13  

SwitchGear Promoter luciferase reporter plasmid: DBN1 promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DBN1

DBN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176883:  view genomic region     (about GC identifiers)

Proteins
for DBN1 gene

Explore the universe of human proteins at neXtProt for DBN1: NX_Q16643

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: DBN1 OriGene Custom Protein Services for DBN1
	GenScript Custom Purified and Recombinant Proteins Services for DBN1
	Novus Biologicals DBN1 Protein Novus Biologicals DBN1 Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DBN1

Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DBN1
	R&D Systems Antibodies for DBN1 (Drebrin 1)
	Cell Signaling Technology (CST) Antibodies for DBN1
	Browse OriGene Antibodies OriGene Custom Antibody Services for DBN1
	GenScript Custom Superior Antibodies Services for DBN1
	Novus Biologicals DBN1 Antibodies
	Search for Antibodies for DBN1 at Abcam
	Uscn Antibodies for DBN1
	ThermoFisher Antibody for DBN1

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DBN1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DBN1

Protein Domains /
Families
for DBN1 gene

ProtoNet protein and cluster: Q16643

Function
for DBN1 gene

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DBN1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DBN1
		8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate DBN1 (see all 34):
		hsa-miR-4307 hsa-miR-517a hsa-miR-517c hsa-miR-1260b hsa-miR-218 hsa-miR-3167 hsa-miR-3649 hsa-miR-520g
		SwitchGear 3'UTR luciferase reporter plasmid: DBN1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DBN1 (see all 7) OriGene shRNA RFP: DBN1 OriGene siRNA: DBN1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DBN1

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for DBN1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DBN1 (see all 6) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DBN1 (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DBN1 (NM_004395)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBN1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBN1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DBN1
		Search LifeMap BioReagents cell lines for DBN1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBN1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

(inferred from 3 alleles) (MGI details for Dbn1)

Pathways & Interactions
for DBN1 gene

	Super-pathway	contained gene-specific pathways
1	Neuroscience	Neuroscience 1.00
2	Cytoskeletal Signaling	Cytoskeletal Signaling 1.00
3	Signaling in Gap Junctions	Signaling in Gap Junctions 1.00

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DBN1

Signaling in Gap Junctions

2 Cell Signaling Technology (CST) Pathways for DBN1

	Neuroscience
	Cytoskeletal Signaling

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

Drugs & Compounds
for DBN1 gene

Transcripts
for DBN1 gene

Expression
for DBN1 gene

DBN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAATAAATG

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DBN1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DBN1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DBN1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DBN1

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBN1

Orthologs
for DBN1 gene

Paralogs
for DBN1 gene

Paralogs for DBN1 gene

DBNL²  CTTN²  HCLS1²  

1 SIMAP similar gene for DBN1 using alignment to 8 protein entries:     DREB_HUMAN (see all proteins):

DBNL

DBN1 for paralogs           About GeneDecksing

Genomic Variants
for DBN1 gene

10/312 NCBI SNPs in DBN1 are shown (see all 312)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs796532761,2	C,	--	176883553(+)	GAGGTG/ACTGCG	5	--	ds5001 int1		2		WA	120
rs680144371,2	C	--	176883675(+)	AAAAA-/AAA       AAAAAAAAAA	7	--	ds5001 ut31 int1		1		NA	2
rs1921558671,2		--	176883757(+)	GAGGGA/GCCACC	5	--	ut31 ds5001 int1		0	--	--	--	--
rs10613791,2	C,F,H	--	176883864(-)	CCCAGC/TTGGGG	2	--	ut31 ese3		6		MN NS	1198
rs728151091,2	C,	--	176883990(+)	ATCTGA/GAGCCC	2	--	ut31		0	--	--	--	--
rs1894180851,2		--	176883998(+)	CCCTGC/GACAGA	2	--	ut31		0	--	--	--	--
rs1474158821,2		--	176884036(+)	ACATAA/GAACTA	2	--	ut31		0	--	--	--	--
rs1118346171,2	F	--	176884161(+)	ACCAGG/AGAAGG	2	--	ut31		1		CSA	4
rs2003346981,2		--	176884533(+)	AGTTAA/GGGACC	2	--	int1		0	--	--	--	--
rs798530901,2	C,F,	--	176884641(+)	ATCATC/TCAGCC	2	--	int1		2		WA EU	711

HapMap Linkage Disequilibrium report for DBN1 (176883609 - 176901402 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DBN1
     3 CNVs: 53135 51643 30224

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DBN1

DNA2.0 Custom Variant and Variant Library Synthesis for DBN1

Disorders / Diseases
for DBN1 gene

12 diseases for DBN1

5 Novoseek disease relationships for DBN1 gene    About this table

Publications
for DBN1 gene

PubMed articles for DBN1 gene, integrated from 9 sources (see all 108): (articles sorted by number of sources associating them with DBN1)

Utopia: connect your pdf to the dynamic world of online information

1. Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene. (PubMed id 8216329)^{1, 2, 3, 9} Toda M.... Uyemura K. (1993)
2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
6. Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. (PubMed id 12761245)^{1, 9} Peitsch W.K....Franke W.W. (2003)
7. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. (PubMed id 12009525)^{1, 9} Shim K.S. and Lubec G. (2002)
8. The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review. (PubMed id 7608104)^{1, 9} Shirao T. (1995)
9. Dynamics of the actin-binding protein drebrin in motile cells and definition of a juxtanuclear drebrin-enriched zone. (PubMed id 16780834)^{1, 9} Peitsch W.K....Franke W.W. (2006)
10. Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. (PubMed id 10604653)^{1, 9} Peitsch W.K....Franke W.W. (1999)

External Searches for DBN1 gene

Genome Databases showing DBN1 gene

Other Databases showing DBN1 gene

Specialized Databases showing DBN1 gene

Products
for DBN1 gene