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Aliases & Descriptions for DBN1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases D0S117E 2 , 3 DKFZp434D064 2 drebrin-1 2
Descriptions Developmentally-regulated brain protein 3 drebrin 1 2 drebrin E 2 drebrin E2 2
Search outside databases for aliases for DBN1 genePrevious GC identifers: GC05M177180 GC05M177726 GC05M176819 GC05M176865 GC05M176867
Summaries for DBN1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for DBN1 : The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role inthe process of neuronal growth. It is a member of the drebrin family of proteins that aredevelopmentally regulated in the brain. A decrease in the amount of this protein in the brain hasbeen implicated as a possible contributing factor in the pathogenesis of memory disturbance inAlzheimer's disease. At least two alternative splice variants encoding different proteinisoforms have been described for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643 Function : Drebrins might play some role in cell migration, extension of neuronal processes andplasticity of dendrites, respectively
Gene Wiki entry for DBN1
Genomic Location for DBN1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DBN1 gene Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3 DBN1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure
GeneLoc location for GC05M176816:
(about GC identifiers )
Start:
176,816,220 bp from pter
End:
176,833,271 bp from pter
Size:
17,052 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000005.8 NT_023133.12 Proteins for DBN1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643 (See
protein sequence )Recommended Name: Drebrin Size : 649 amino acids; 71429 Da
Subunit : Binds F-actin
Subcellular location : Cytoplasm
Secondary accessions : B2RBG0 Q9UFZ5Alternative splicing : 2 isoforms : Q16643-1 Q16643-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_004386.2 NP_543157.1 ENSEMBL proteins: ENSP00000292385 ENSP00000377193 ENSP00000377195 ENSP00000308532 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 4 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for DBN1: Assays for DBN1:
Protein
Domains/ Families for DBN1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q16643 ProtoNet protein and cluster: Q16643
1 Blocks protein family : IPB002108 Actin-binding UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643 Similarity : Contains 1 ADF-H domain
Gene Function for DBN1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich , RNAi from
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RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_080881 Applied Biosystems Silencer ® siRNAs for DBN1 Sigma-Aldrich siRNA for DBN1 Sigma-Aldrich shRNA Panels and shRNA for DBN1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004395                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004395                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_004395  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_080881 UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643 Function : Drebrins might play some role in cell migration, extension of neuronal processes andplasticity of dendrites, respectively
Genatlas biochemistry entry for DBN1 :drebrin,actin binding protein involved in neuronal growth,developmentally regulated,embryonicisoforms E1,E2 2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for DBN1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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5/10 Interacting proteins for DBN1 (ENSP00000292385 3 Q16643 1 , 2 ) via UniProtKB, MINT, and/or STRING (see all 10
)About this table 5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
):
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Novoseek and Drugs according to
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PharmGKB )
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Transcripts for DBN1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_080881 Sigma-Aldrich siRNA for DBN1 Sigma-Aldrich shRNA Panels and shRNA for DBN1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_004395 NM_080881
REFSEQ mRNAs for DBN1 gene (2 alternative transcripts): NM_004395.3 NM_080881.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004395 NM_080881
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_004395                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_004395                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_004395  
Additional cDNA sequence: AK094125.1 AK225523.1 AK295295.1 AK314645.1 AL110225.1 BC000283.1 BC007281.1 BC007567.1 BC114553.1 D17530.1 U00802.1
22 DOTS entries : DT.456300 DT.100662726 DT.100817464 DT.97844144 DT.100027314 DT.95171424 DT.100817454 DT.100817469 DT.100687880 DT.100657865 DT.100817461 DT.120810927 DT.97791817 DT.100817471 DT.100733779 DT.100817467 DT.120810907 DT.120810958 DT.95171422 DT.95171430 DT.100663063 DT.99992448
24/255 AceView cDNA sequences (see all 255
):AI637966 BQ954237 BI831134 BF515686 BP872369 BQ881944 BF338628 AK094125 T28437 BF924338 AA903534 BX952568 BM558409 AA853109 BQ918816 BE797393 AU141639 BQ950648 BM837519 BQ057914 BI829141 BM918417 AI904931 T08014
highest scoring ESTs for DBN1 :U00802 AI978592 AK094125 AL134622 AL535268 AL556638 AU099234 AU120589 AU127414 AU129533
Unigene Cluster for DBN1: Drebrin 1 Hs.130316 [show with all ESTs ] Unigene Representative Sequence: NM_080881 GeneLoc Exon Structure 5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DBN1 (see all 6
) ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c SP1 :         -               -     -                   SP2 :   -   -     -               -     -                   SP3 :   -   -     -               -     -                   SP4 :                           -                   SP5 :                                            
About this scheme ECgene alternative splicing isoforms for DBN1 4 Ensembl transcripts including schematic representations : ENST00000292385
ENST00000393563
ENST00000393565
ENST00000309007
Expression for DBN1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DBN1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DBN1 1 / 2 / 3
6 probe-sets matching DBN1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCAATAAATGSOURCE GeneReport for Unigene cluster: Hs.130316 Expression variation in blood from EXPOLDB for DBN1
UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643 Tissue specificity : Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney andpancreas
Orthologs for DBN1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for DBN1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for DBN1 ENSEMBL Gene Tree for DBN1 Paralogs for DBN1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for DBN1 gene HCLS1 2 CTTN 2 DBNL 2
SNPs/Variants for DBN1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for DBN1 (up to first 250kb)
Disorders & Mutations for DBN1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
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Blood group antigen gene mutations by BGMUT ,
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OMIM: 126660 5 Novoseek disease relationships for DBN1 gene
About this table 1 PharmGKB disease relationship for DBN1 gene About this table
Medical News for DBN1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for DBN1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/85 PubMed articles for DBN1 gene (see all 85
): Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene. (PubMed id 8216329) 1, 2, 3, 4 Toda M.... Uyemura K. (1993) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PubMed id 16094384) 3, 4 Tao W.A.... Aebersold R. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935) 3, 4 Beausoleil S.A....Gygi S.P. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801) 3, 4 Gevaert K.... Vandekerckhove J. (2003) Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. (PubMed id 12761245) 1, 3 Peitsch W.K....Franke W.W. (2003) Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. (PubMed id 12009525) 1, 3 Shim K.S. and Lubec G. (2002) The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review. (PubMed id 7608104) 1, 3 Shirao T. (1995)
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Genome Databases showing DBN1
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Specialized Databases showing DBN1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for DBN1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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