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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DBN1 Gene

protein-coding   GIFtS: 56
GCID: GC05M176883

drebrin 1


(Previous symbol: D0S117E)
 Explore 12 diseases affiliated with
DBN1 via our new
 Human Malady Compendium 
Biological research products
for DBN1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Drebrin 11 2     Drebrin E2
D0S117E1 2 3     Drebrin E22
Developmentally-Regulated Brain Protein2 3     Drebrin-11
Drebrin1     

External Ids:    HGNC: 26951   Entrez Gene: 16272   Ensembl: ENSG000001137587   OMIM: 1266605   UniProtKB: Q166433   

Export aliases for DBN1 gene to outside databases

Previous GC identifers: GC05M177180 GC05M177726 GC05M176819 GC05M176865 GC05M176867 GC05M176816 GC05M171803


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DBN1:
The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of
neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A
decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the
pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different
protein isoforms have been described for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643
Function: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites,
respectively

Gene Wiki entry for DBN1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_023133.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DBN1 gene promoter:
         GCNF-1   GCNF   GCNF-2   E47   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDBN1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DBN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DBN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.3   Ensembl cytogenetic band:  5q35.3   HGNC cytogenetic band: 5q35.3

DBN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBN1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M176883:  view genomic region     (about GC identifiers)

Start:
176,883,609 bp from pter      End:
176,901,402 bp from pter
Size:
17,794 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643 (See protein sequence)
Recommended Name: Drebrin  
Size: 649 amino acids; 71429 Da
Subunit: Binds F-actin
Subcellular location: Cytoplasm
Secondary accessions: B2RBG0 Q9UFZ5
Alternative splicing: 2 isoforms:  Q16643-1   Q16643-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DBN1: NX_Q16643

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16643

  • DBN1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_004386.2  NP_543157.1  

    ENSEMBL proteins: 
     ENSP00000308532   ENSP00000292385   ENSP00000377195   ENSP00000423208   ENSP00000422854  
     ENSP00000425546   ENSP00000421465   ENSP00000377193  

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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DBN1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm NAS12009525
    GO:0005886plasma membrane IEA--
    GO:0005921gap junction IEA--
    GO:0015629actin cytoskeleton ISS--


    DBN1 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    DBN1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002108 Actin-bd_cofilin/tropomyosin

    Graphical View of Domain Structure for InterPro Entry Q16643

    ProtoNet protein and cluster: Q16643

    1 Blocks protein family: IPB002108 Actin-binding

    UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643
    Similarity: Contains 1 ADF-H domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643
    Function: Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites,
    respectively

         Genatlas biochemistry entry for DBN1:
    drebrin,actin binding protein involved in neuronal growth,developmentally regulated,embryonic isoforms E1,E2

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    hsa-miR-4307 hsa-miR-517a hsa-miR-517c hsa-miR-1260b hsa-miR-218 hsa-miR-3167 hsa-miR-3649 hsa-miR-520g
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding NAS12761245
    GO:0005522profilin binding ISS--


    DBN1 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Dbn1tm1.1Shira for DBN1
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dbn1):
     adipose tissue  behavior/neurological  growth/size  hematopoietic system  homeostasis/metabolism 
     no phenotypic analysis 

    DBN1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Neuroscience
    Neuroscience1.00
    2Cytoskeletal Signaling
    Cytoskeletal Signaling1.00
    3Signaling in Gap Junctions
    Signaling in Gap Junctions1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DBN1
        Signaling in Gap Junctions

    2 Cell Signaling Technology (CST) Pathways for DBN1
        Neuroscience
    Cytoskeletal Signaling



    DBN1 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DBN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/45 Interacting proteins for DBN1 (Q166432, 3 ENSP000002923854) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TPT1P136932, 3, ENSP000003683504MINT-8275171 I2D: score=2 STRING: ENSP00000368350
    BAK1Q166112, 3MINT-8249245 I2D: score=2 
    BTRCQ9Y2972, 3MINT-8249707 I2D: score=2 
    CDK2AP2O759562, 3MINT-8251175 I2D: score=2 
    DUSP23Q9BVJ72, 3MINT-8254622 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007015actin filament organization ISS--
    GO:0007399nervous system development ----
    GO:0010643cell communication by chemical coupling IEA--
    GO:0010644cell communication by electrical coupling IEA--
    GO:0032507maintenance of protein location in cell IEA--


    DBN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DBN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DBN1
    4 Novoseek chemical compound relationships for DBN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutamate 21.6 6 16368245 (3), 17590478 (1), 19339553 (1)
    nmda 19.1 3 16368245 (3)
    retinoic acid 4.57 1 8078100 (1)
    calcium 0 2 19948240 (2)

    Search CenterWatch for drugs/clinical trials and news about DBN1 / DREB 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DBN1 gene (2 alternative transcripts): 
    NM_004395.3  NM_080881.2  

    Unigene Cluster for DBN1:

    Drebrin 1
    Hs.130316  [show with all ESTs]
    Unigene Representative Sequence: NM_080881
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309007(uc011dga.1 uc003mgy.2 uc010jkn.1) ENST00000292385(uc003mgx.2)
    ENST00000472831 ENST00000393565(uc003mgz.1) ENST00000512501 ENST00000467054
    ENST00000477391 ENST00000471767 ENST00000506117 ENST00000514833 ENST00000505550
    ENST00000393563

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    8/34 QIAGEN miScript miRNA Assays for microRNAs that regulate DBN1 (see all 34):
    hsa-miR-4307 hsa-miR-517a hsa-miR-517c hsa-miR-1260b hsa-miR-218 hsa-miR-3167 hsa-miR-3649 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidDBN1 3' UTR sequence
    Inhib. RNA
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    Additional cDNA sequence: 

    AK094125.1 AK225523.1 AK295295.1 AK314645.1 AL110225.1 BC000283.1 BC007281.1 BC007567.1 
    BC114553.1 D17530.1 U00802.1 

    22 DOTS entries:

    DT.456300  DT.100662726  DT.100817464  DT.97844144  DT.100027314  DT.95171424  DT.100817454  DT.100817469 
    DT.100657865  DT.100687880  DT.100817461  DT.120810927  DT.97791817  DT.100817471  DT.100733779  DT.100817467 
    DT.120810907  DT.120810958  DT.95171422  DT.95171430  DT.100663063  DT.99992448 

    24/255 AceView cDNA sequences (see all 255):

    AI637966 BQ881944 BF338628 BM918417 BP872369 BI829141 BM837519 T08014 
    BQ057914 AI904931 BQ918816 AA903534 BE797393 AU141639 BQ950648 BM558409 
    BX952568 AA853109 BI831134 BF515686 T28437 AK094125 BF924338 BQ954237 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for DBN1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17a · 17b · 17c
    SP1:                          -                                         -           -                                                   
    SP2:        -     -           -                                         -           -                                                   
    SP3:        -     -           -                                         -           -                                                   
    SP4:                                                                                -                                                   
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for DBN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DBN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAATAAATG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See DBN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DBN1

    SOURCE GeneReport for Unigene cluster: Hs.130316

    UniProtKB/Swiss-Prot: DREB_HUMAN, Q16643
    Tissue specificity: Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas

        SABiosciences Expression via Pathway-Focused PCR Array including DBN1: 
              Gap Junctions in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DBN1 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dbn11 , 5 drebrin 11, 5 86.06(n)1
    89.2(a)1
      13 (30.06 cM)5
    563201  NM_001177372.11  NP_001170843.11 
     554734295 
    chicken
    (Gallus gallus)
    Aves DBN11 drebrin 1 71.54(n)
    69.22(a)
      396496  NM_205499.1  NP_990830.1 
    lizard
    (Anolis carolinensis)
    Reptilia DBN16
    --
    --
    57(a)
    36(a)
    1 ↔ 1
    possible ortholog
    2(145751040-145768750)
    GL344264.1(21842-46080)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.243192 Xenopus laevis transcribed sequence with weak similarity more 73.73(n)    BX852608.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5611531 drebrin-like 66.28(n)
    64.91(a)
      561153  XM_001920031.3  XP_001920066.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG100836
    --
    18(a)
    1 → many
    3L(13476633-13479380)
    worm
    (Caenorhabditis elegans)
    Secernentea K08E3.46
    Protein K08E3.4
    14(a)
    1 → many
    III(13759344-13761968)


    ENSEMBL Gene Tree for DBN1 (if available)
    TreeFam Gene Tree for DBN1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DBN1 gene
    DBNL2  CTTN2  HCLS12  
    1 SIMAP similar gene for DBN1 using alignment to 8 protein entries:     DREB_HUMAN (see all proteins):
    DBNL

    DBN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/312 NCBI SNPs in DBN1 are shown (see all 312    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs796532761,2
    C,--176883553(+) GAGGTG/ACTGCG 5 -- ds5001 int12Minor allele frequency- A:0.04WA 120
    rs680144371,2
    C--176883675(+) AAAAA-/AAA   
       AAAAA
    AAAAA
    7 -- ds5001 ut31 int11Minor allele frequency- AAAAAAAA:0.00NA 2
    rs1921558671,2
    --176883757(+) GAGGGA/GCCACC 5 -- ut31 ds5001 int10--------
    rs10613791,2
    C,F,H--176883864(-) CCCAGC/TTGGGG 2 -- ut31 ese36Minor allele frequency- T:0.01MN NS 1198
    rs728151091,2
    C,--176883990(+) ATCTGA/GAGCCC 2 -- ut310--------
    rs1894180851,2
    --176883998(+) CCCTGC/GACAGA 2 -- ut310--------
    rs1474158821,2
    --176884036(+) ACATAA/GAACTA 2 -- ut310--------
    rs1118346171,2
    F--176884161(+) ACCAGG/AGAAGG 2 -- ut311Minor allele frequency- A:0.50CSA 4
    rs2003346981,2
    --176884533(+) AGTTAA/GGGACC 2 -- int10--------
    rs798530901,2
    C,F,--176884641(+) ATCATC/TCAGCC 2 -- int12Minor allele frequency- T:0.01WA EU 711

    HapMap Linkage Disequilibrium report for DBN1 (176883609 - 176901402 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for DBN1
         3 CNVs: 53135 51643 30224

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DBN1 for disorders           About GeneDecksing

    OMIM gene information: 126660    OMIM disorders: --

    12 diseases for DBN1:    About MalaCards
    alzheimer's disease    mantle cell lymphoma    acute lymphoblastic leukemia    down syndrome
    lymphoblastic leukemia    neuronitis    bipolar disorder    dementia
    schizophrenia    leukemia    cerebritis    neuroblastoma

    2 diseases from the University of Copenhagen DISEASES database for DBN1:
    Down syndrome     Alzheimer's disease

    5 Novoseek disease relationships for DBN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 55 8 12009525 (2), 20183806 (1), 15484828 (1), 15140563 (1) (see all 5)
    alzheimers disease 47.2 11 12009525 (2), 8838578 (2), 20183806 (1), 15484828 (1) (see all 7)
    encephalopathy 14.7 1 11771761 (1)
    schizophrenia 0 2 16402129 (1)
    dementia 0 1 10374754 (1)


    Export disorders for DBN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DBN1 gene, integrated from 9 sources (see all 108):
    (articles sorted by number of sources associating them with DBN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of cDNA encoding human drebrin E and chromosomal mapping of its gene. (PubMed id 8216329)1, 2, 3, 9 Toda M.... Uyemura K. (1993)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    6. Cell biological and biochemical characterization of drebrin complexes in mesangial cells and podocytes of renal glomeruli. (PubMed id 12761245)1, 9 Peitsch W.K....Franke W.W. (2003)
    7. Drebrin, a dendritic spine protein, is manifold decreased in brains of patients with Alzheimer's disease and Down syndrome. (PubMed id 12009525)1, 9 Shim K.S. and Lubec G. (2002)
    8. The roles of microfilament-associated proteins, drebrins, in brain morphogenesis: a review. (PubMed id 7608104)1, 9 Shirao T. (1995)
    9. Dynamics of the actin-binding protein drebrin in motile cells and definition of a juxtanuclear drebrin-enriched zone. (PubMed id 16780834)1, 9 Peitsch W.K....Franke W.W. (2006)
    10. Drebrin is a widespread actin-associating protein enriched at junctional plaques, defining a specific microfilament anchorage system in polar epithelial cells. (PubMed id 10604653)1, 9 Peitsch W.K....Franke W.W. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1627 HGNC: 2695 AceView: DBN1 Ensembl:ENSG00000113758 euGenes: HUgn1627
    ECgene: DBN1 H-InvDB: DBN1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DBN1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DBN1 gene:
    Search GeneIP for patents involving DBN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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