Aliases for DBI Gene
External Ids for DBI Gene
Previous GeneCards Identifiers for DBI Gene
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for DBI Gene
DBI (Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein)) is a Protein Coding gene. Diseases associated with DBI include Hepatic Coma. Among its related pathways are Benzodiazepine Pathway, Pharmacodynamics and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include protein dimerization activity and fatty-acyl-CoA binding. An important paralog of this gene is ACBD5.
UniProtKB/Swiss-Prot for DBI Gene
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.