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Aliases for DBI Gene

Aliases for DBI Gene

  • Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein) 2 3 5
  • Endozepine 2 3 4
  • Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-Coenzyme A Binding Protein) 2 3
  • Diazepam-Binding Inhibitor 3 4
  • ACBP 3 4
  • EP 3 4
  • Cholecystokinin-Releasing Peptide, Trypsin-Sensitive 3
  • Acyl-Coenzyme A Binding Domain Containing 1 3
  • Acyl Coenzyme A Binding Protein 3
  • GABA Receptor Modulator 3
  • CCK-RP 3
  • ACBD1 3

External Ids for DBI Gene

Previous GeneCards Identifiers for DBI Gene

  • GC02P117330
  • GC02P118045
  • GC02P120031
  • GC02P120219
  • GC02P120220
  • GC02P119840
  • GC02P120124
  • GC02P112449

Summaries for DBI Gene

Entrez Gene Summary for DBI Gene

  • This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DBI Gene

DBI (Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein)) is a Protein Coding gene. Diseases associated with DBI include hepatic coma. Among its related pathways are PPAR signaling pathway and Regulation of cholesterol biosynthesis by SREBP (SREBF). GO annotations related to this gene include protein dimerization activity and fatty-acyl-CoA binding. An important paralog of this gene is ACBD5.

UniProtKB/Swiss-Prot for DBI Gene

  • Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Gene Wiki entry for DBI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBI Gene

Genomics for DBI Gene

Regulatory Elements for DBI Gene

Promoters for DBI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DBI on UCSC Golden Path with GeneCards custom track

Genomic Location for DBI Gene

Chromosome:
2
Start:
119,366,921 bp from pter
End:
119,372,560 bp from pter
Size:
5,640 bases
Orientation:
Plus strand

Genomic View for DBI Gene

Genes around DBI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBI Gene

Proteins for DBI Gene

  • Protein details for DBI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07108-ACBP_HUMAN
    Recommended name:
    Acyl-CoA-binding protein
    Protein Accession:
    P07108
    Secondary Accessions:
    • B8ZWD2
    • B8ZWD6
    • B8ZWD7
    • P08869
    • Q4VWZ6
    • Q53SQ7
    • Q6IB48
    • Q9UCI8

    Protein attributes for DBI Gene

    Size:
    87 amino acids
    Molecular mass:
    10044 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DBI Gene

    Alternative splice isoforms for DBI Gene

neXtProt entry for DBI Gene

Proteomics data for DBI Gene at MOPED

Post-translational modifications for DBI Gene

  • Ubiquitination at Lys 55 and Lys 77
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for DBI Gene

Domains & Families for DBI Gene

Graphical View of Domain Structure for InterPro Entry

P07108

UniProtKB/Swiss-Prot:

ACBP_HUMAN :
  • Contains 1 ACB (acyl-CoA-binding) domain.
  • Belongs to the ACBP family.
Domain:
  • Contains 1 ACB (acyl-CoA-binding) domain.
Family:
  • Belongs to the ACBP family.
genes like me logo Genes that share domains with DBI: view

No data available for Gene Families for DBI Gene

Function for DBI Gene

Molecular function for DBI Gene

GENATLAS Biochemistry:
diazepam binding inhibitor (?GABA receptor modulator),endozepine
UniProtKB/Swiss-Prot Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Gene Ontology (GO) - Molecular Function for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030156 benzodiazepine receptor binding TAS 3020548
genes like me logo Genes that share ontologies with DBI: view
genes like me logo Genes that share phenotypes with DBI: view

Animal Models for DBI Gene

MGI Knock Outs for DBI:

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DBI Gene

Localization for DBI Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBI Gene

Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding (PubMed:17953517). {ECO:0000269 PubMed:17953517}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBI Gene COMPARTMENTS Subcellular localization image for DBI gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
golgi apparatus 5
cytosol 3
mitochondrion 3
nucleus 2

Gene Ontology (GO) - Cellular Components for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0097038 perinuclear endoplasmic reticulum IDA 21698759
genes like me logo Genes that share ontologies with DBI: view

Pathways & Interactions for DBI Gene

genes like me logo Genes that share pathways with DBI: view

Pathways by source for DBI Gene

1 BioSystems pathway for DBI Gene
1 PharmGKB pathway for DBI Gene
1 KEGG pathway for DBI Gene

SIGNOR curated interactions for DBI Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DBI Gene

None

Drugs & Compounds for DBI Gene

(5) Drugs for DBI Gene - From: DrugBank, Novoseek, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexadecanal Experimental Pharma Target 0
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra Target 0

(38) Additional Compounds for DBI Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with DBI: view

Transcripts for DBI Gene

Unigene Clusters for DBI Gene

Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DBI Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - - - -
SP8: - -

Relevant External Links for DBI Gene

GeneLoc Exon Structure for
DBI
ECgene alternative splicing isoforms for
DBI

Expression for DBI Gene

mRNA expression in normal human tissues for DBI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DBI Gene

This gene is overexpressed in Oral epithelium (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DBI Gene



SOURCE GeneReport for Unigene cluster for DBI Gene Hs.78888

mRNA Expression by UniProt/SwissProt for DBI Gene

P07108-ACBP_HUMAN
Tissue specificity: Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.
genes like me logo Genes that share expression patterns with DBI: view

Protein tissue co-expression partners for DBI Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DBI Gene

Orthologs for DBI Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DBI Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DBI 35
  • 91.57 (n)
  • 93.1 (a)
DBI 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbi 35
  • 82.38 (n)
  • 78.16 (a)
Dbi 16
Dbi 36
  • 51 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DBI 35
  • 100 (n)
  • 100 (a)
DBI 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbi 35
  • 82.38 (n)
  • 78.16 (a)
dog
(Canis familiaris)
Mammalia DBI 36
  • 59 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DBI 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBI 35
  • 74.71 (n)
  • 75.86 (a)
DBI 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBI 36
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75740 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2125 35
zebrafish
(Danio rerio)
Actinopterygii dbi 35
  • 73.95 (n)
  • 79.31 (a)
zgc77734 35
dbi 36
  • 78 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3079 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007460 35
  • 63.75 (n)
  • 58.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta Dbi 35
  • 57.36 (n)
  • 51.16 (a)
CG15829 36
  • 40 (a)
ManyToMany
CG5804 36
  • 43 (a)
ManyToMany
CG8498 36
  • 52 (a)
ManyToMany
CG8628 36
  • 46 (a)
ManyToMany
CG8629 36
  • 46 (a)
ManyToMany
Dbi 36
  • 50 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acbp-1 35
  • 63.41 (n)
  • 56.1 (a)
acbp-1 36
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL188W 35
  • 57.61 (n)
  • 45.68 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05643g 35
  • 56.59 (n)
  • 48.84 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACB1 35
  • 57.61 (n)
  • 50.62 (a)
ACB1 36
  • 47 (a)
OneToMany
ACB1 38
wheat
(Triticum aestivum)
Liliopsida Ta.1334 35
corn
(Zea mays)
Liliopsida Zm.7156 35
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1539.06 35
  • 57.32 (n)
  • 59.76 (a)
Species with no ortholog for DBI:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DBI Gene

ENSEMBL:
Gene Tree for DBI (if available)
TreeFam:
Gene Tree for DBI (if available)

Paralogs for DBI Gene

Paralogs for DBI Gene

(7) SIMAP similar genes for DBI Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DBI: view

Variants for DBI Gene

Sequence variations from dbSNP and Humsavar for DBI Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_048160 -
rs8192506 - 119,372,265(+) ATGCC(A/G)TGAAA nc-transcript-variant, reference, missense
rs8192507 - 119,372,310(+) AATAC(A/G)GGATA nc-transcript-variant, reference, missense
rs1050698 -- 119,372,446(+) TGCTC(A/C)CCATA nc-transcript-variant, utr-variant-3-prime
rs956309 -- 119,370,906(+) GGGCA(C/T)GTGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBI Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
nsv874960 CNV Gain 21882294
nsv508862 CNV Insertion 20534489

Variation tolerance for DBI Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBI Gene

HapMap Linkage Disequilibrium report
DBI
Human Gene Mutation Database (HGMD)
DBI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBI Gene

Disorders for DBI Gene

MalaCards: The human disease database

(1) MalaCards diseases for DBI Gene - From: DISEASES

Disorder Aliases PubMed IDs
hepatic coma
  • hepatocerebral intoxication
- elite association - COSMIC cancer census association via MalaCards
Search DBI in MalaCards View complete list of genes associated with diseases

Relevant External Links for DBI

Genetic Association Database (GAD)
DBI
Human Genome Epidemiology (HuGE) Navigator
DBI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBI
genes like me logo Genes that share disorders with DBI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DBI Gene

Publications for DBI Gene

  1. High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. (PMID: 17044054) Taskinen J.P. … Wierenga R.K. (Proteins 2007) 3 4 23 67
  2. ACBP knockdown leads to down-regulation of genes encoding rate-limiting enzymes in cholesterol and fatty acid metabolism. (PMID: 20511713) Vock C. … DAPring F. (Cell. Physiol. Biochem. 2010) 3 23
  3. Transcriptional regulation of HMG-CoA synthase and HMG-CoA reductase genes by human ACBP. (PMID: 19088433) Vock C. … Nitz I. (Cell. Physiol. Biochem. 2008) 3 23
  4. Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations. (PMID: 17262885) Fisher E. … DAPring F. (Mol Nutr Food Res 2007) 3 23
  5. Acyl coenzyme A-binding protein augments bid-induced mitochondrial damage and cell death by activating mu-calpain. (PMID: 16908521) Shulga N. … Pastorino J.G. (J. Biol. Chem. 2006) 3 23

Products for DBI Gene

Sources for DBI Gene

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