Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DBI Gene

Aliases for DBI Gene

  • Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein) 2 3
  • Endozepine 2 3 4
  • Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-Coenzyme A Binding Protein) 2 3
  • Diazepam-Binding Inhibitor 3 4
  • ACBP 3 4
  • EP 3 4
  • Cholecystokinin-Releasing Peptide, Trypsin-Sensitive 3
  • Acyl-Coenzyme A Binding Domain Containing 1 3
  • Acyl Coenzyme A Binding Protein 3
  • Acyl-CoA-Binding Protein 3
  • GABA Receptor Modulator 3
  • CCK-RP 3
  • ACBD1 3

External Ids for DBI Gene

Summaries for DBI Gene

Entrez Gene Summary for DBI Gene

  • This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DBI Gene

DBI (Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein)) is a Protein Coding gene. Diseases associated with DBI include withdrawal disorder and alcoholic pancreatitis. Among its related pathways are Regulation of Cholesterol Biosynthesis by SREBP (SREBF) and Benzodiazepine Pathway, Pharmacodynamics. GO annotations related to this gene include lipid binding and benzodiazepine receptor binding. An important paralog of this gene is ACBD7.

UniProtKB/Swiss-Prot for DBI Gene

  • Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor

Gene Wiki entry for DBI Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBI Gene

Genomics for DBI Gene

Genomic Location for DBI Gene

Start:
119,366,921 bp from pter
End:
119,372,560 bp from pter
Size:
5,640 bases
Orientation:
Plus strand

Genomic View for DBI Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DBI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBI Gene

Regulatory Elements for DBI Gene

Proteins for DBI Gene

  • Protein details for DBI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07108-ACBP_HUMAN
    Recommended name:
    Acyl-CoA-binding protein
    Protein Accession:
    P07108
    Secondary Accessions:
    • B8ZWD2
    • B8ZWD6
    • B8ZWD7
    • P08869
    • Q4VWZ6
    • Q53SQ7
    • Q6IB48
    • Q9UCI8

    Protein attributes for DBI Gene

    Size:
    87 amino acids
    Molecular mass:
    10044 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DBI Gene

    Alternative splice isoforms for DBI Gene

neXtProt entry for DBI Gene

Proteomics data for DBI Gene at MOPED

Post-translational modifications for DBI Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys55 and Lys77

No data available for DME Specific Peptides for DBI Gene

Domains for DBI Gene

UniProtKB/Swiss-Prot:

ACBP_HUMAN
Domain:
  • Contains 1 ACB (acyl-CoA-binding) domain.:
    • P07108
Family:
  • Belongs to the ACBP family.:
    • P07108
genes like me logo Genes that share domains with DBI: view

No data available for Gene Families for DBI Gene

Function for DBI Gene

Molecular function for DBI Gene

GENATLAS Biochemistry: diazepam binding inhibitor (?GABA receptor modulator),endozepine
UniProtKB/Swiss-Prot Function: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor

Gene Ontology (GO) - Molecular Function for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000062 fatty-acyl-CoA binding --
GO:0008289 lipid binding IEA --
GO:0030156 benzodiazepine receptor binding TAS 3020548
GO:0036042 long-chain fatty acyl-CoA binding IDA 21079819
GO:0046983 protein dimerization activity IDA 21079819
genes like me logo Genes that share ontologies with DBI: view
genes like me logo Genes that share phenotypes with DBI: view

Animal Models for DBI Gene

MGI Knock Outs for DBI:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DBI Gene

Localization for DBI Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBI Gene

Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBI Gene COMPARTMENTS Subcellular localization image for DBI gene
Compartment Confidence
endoplasmic reticulum 5
golgi apparatus 5
cytosol 3
mitochondrion 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005794 Golgi apparatus IEA --
GO:0070062 extracellular exosome IDA 20458337
GO:0097038 perinuclear endoplasmic reticulum IDA 21698759
genes like me logo Genes that share ontologies with DBI: view

Pathways for DBI Gene

genes like me logo Genes that share pathways with DBI: view

Pathways by source for DBI Gene

1 BioSystems pathway for DBI Gene
1 PharmGKB pathway for DBI Gene
1 KEGG pathway for DBI Gene

Gene Ontology (GO) - Biological Process for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001662 behavioral fear response IEA --
GO:0001942 hair follicle development IEA --
GO:0006641 triglyceride metabolic process IEA --
GO:0006810 transport IEA --
GO:0007611 learning or memory IEA --
genes like me logo Genes that share ontologies with DBI: view

Compounds for DBI Gene

(32) HMDB Compounds for DBI Gene

Compound Synonyms Cas Number PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate Coenzyme A
10018-95-8
(2E)-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-CoA
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate Coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
38795-33-4

(2) Drugbank Compounds for DBI Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Coenzyme A
85-61-0 target
Hexadecanal
  • 16-Hexadecanal
629-80-1 target

(9) Novoseek inferred chemical compound relationships for DBI Gene

Compound -log(P) Hits PubMed IDs
acyl-coa 90.8 61
diazepam 62.9 7
fatty acid 54 8
benzodiazepine 50.5 4
sterol 46.3 4
genes like me logo Genes that share compounds with DBI: view

Transcripts for DBI Gene

Unigene Clusters for DBI Gene

Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DBI Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - - - -
SP8: - -

Relevant External Links for DBI Gene

GeneLoc Exon Structure for
DBI
ECgene alternative splicing isoforms for
DBI

Expression for DBI Gene

mRNA expression in normal human tissues for DBI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DBI Gene

SOURCE GeneReport for Unigene cluster for DBI Gene Hs.78888

mRNA Expression by UniProt/SwissProt for DBI Gene

P07108-ACBP_HUMAN
Tissue specificity: Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.
genes like me logo Genes that share expressions with DBI: view

Orthologs for DBI Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DBI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBI 36
  • 100 (n)
  • 100 (a)
DBI 37
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DBI 36
  • 91.57 (n)
  • 93.1 (a)
DBI 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBI 37
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dbi 36
  • 82.38 (n)
  • 78.16 (a)
Dbi 16
Dbi 37
  • 51 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DBI 37
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dbi 36
  • 82.38 (n)
  • 78.16 (a)
chicken
(Gallus gallus)
Aves DBI 36
  • 74.71 (n)
  • 75.86 (a)
DBI 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBI 37
  • 80 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2125 36
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75740 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3079 36
zebrafish
(Danio rerio)
Actinopterygii dbi 36
  • 73.95 (n)
  • 79.31 (a)
dbi 37
  • 78 (a)
OneToOne
zgc77734 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007460 36
  • 63.75 (n)
  • 58.75 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15829 37
  • 40 (a)
ManyToMany
CG5804 37
  • 43 (a)
ManyToMany
CG8498 37
  • 52 (a)
ManyToMany
CG8628 37
  • 46 (a)
ManyToMany
CG8629 37
  • 46 (a)
ManyToMany
Dbi 36
  • 57.36 (n)
  • 51.16 (a)
Dbi 37
  • 50 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acbp-1 36
  • 63.41 (n)
  • 56.1 (a)
acbp-1 37
  • 53 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL188W 36
  • 57.61 (n)
  • 45.68 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACB1 36
  • 57.61 (n)
  • 50.62 (a)
ACB1 37
  • 47 (a)
OneToMany
ACB1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05643g 36
  • 56.59 (n)
  • 48.84 (a)
corn
(Zea mays)
Liliopsida Zm.7156 36
wheat
(Triticum aestivum)
Liliopsida Ta.1334 36
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1539.06 36
  • 57.32 (n)
  • 59.76 (a)
Species with no ortholog for DBI:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DBI Gene

ENSEMBL:
Gene Tree for DBI (if available)
TreeFam:
Gene Tree for DBI (if available)

Paralogs for DBI Gene

Paralogs for DBI Gene

Selected SIMAP similar genes for DBI Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DBI: view

Variants for DBI Gene

Sequence variations from dbSNP and Humsavar for DBI Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs956309 -- 119,370,906(+) GGGCA(C/T)GTGTG intron-variant
rs1050698 -- 119,372,446(+) TGCTC(A/C)CCATA utr-variant-3-prime, nc-transcript-variant
rs1803481 -- 119,372,278(+) TTACA(C/T)CAACA missense, reference, nc-transcript-variant
rs1803482 -- 119,372,380(+) TTTTT(A/T)TCTAA utr-variant-3-prime, nc-transcript-variant
rs2289944 -- 119,372,815(-) TCCCC(A/G)TCAGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DBI Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV Gain 19166990
nsv874960 CNV Gain 21882294
nsv508862 CNV Insertion 20534489

Relevant External Links for DBI Gene

HapMap Linkage Disequilibrium report
DBI
Human Gene Mutation Database (HGMD)
DBI

Disorders for DBI Gene

(2) University of Copenhagen DISEASES for DBI Gene

(2) Novoseek inferred disease relationships for DBI Gene

Disease -log(P) Hits PubMed IDs
fatty liver 30.5 1
insulin resistance 0 1

Relevant External Links for DBI

Genetic Association Database (GAD)
DBI
Human Genome Epidemiology (HuGE) Navigator
DBI
genes like me logo Genes that share disorders with DBI: view

No data available for UniProtKB/Swiss-Prot for DBI Gene

Publications for DBI Gene

  1. Identification of new acyl-CoA binding protein transcripts in human and mouse. (PMID: 16055366) Nitz I. … Burwinkel B. (Int. J. Biochem. Cell Biol. 2005) 3 4 23
  2. Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations. (PMID: 17262885) Fisher E. … DAPring F. (Mol Nutr Food Res 2007) 3 23 49
  3. High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. (PMID: 17044054) Taskinen J.P. … Wierenga R.K. (Proteins 2007) 3 4 23
  4. ACBP knockdown leads to down-regulation of genes encoding rate-limiting enzymes in cholesterol and fatty acid metabolism. (PMID: 20511713) Vock C. … DAPring F. (Cell. Physiol. Biochem. 2010) 3 23
  5. New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene. (PMID: 1440058) Todd S. … Naylor S.L. (Somat. Cell Mol. Genet. 1992) 2 3

Products for DBI Gene

Sources for DBI Gene

Back to Top

Content