Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DBI Gene

protein-coding GIFtS: 63
GCID: GC02P120124

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA...

(Previous names: diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme...)

Explore 19 diseases affiliated with
DBI via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein)¹ ²		Acyl Coenzyme A Binding Protein²
ACBP¹ ² ³		Acyl-CoA-Binding Protein²
ACBD1¹ ²		Acyl-Coenzyme A Binding Domain Containing 1²
Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-Coenzyme A Binding Protein)¹ ²		Cholecystokinin-Releasing Peptide, Trypsin-Sensitive²
Diazepam-Binding Inhibitor² ³		Endozepine³
EP² ³		GABA Receptor Modulator²
CCK-RP²		Endozepine³

External Ids:	HGNC: 2690¹	Entrez Gene: 1622²	Ensembl: ENSG00000155368⁷	OMIM: 125950⁵	UniProtKB: P07108³

Export aliases for DBI gene to outside databases

Previous GC identifers: GC02P117330 GC02P118045 GC02P120031 GC02P120219 GC02P120220 GC02P119840 GC02P112449

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DBI:

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid

metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A

gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the

most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for

medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback

regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a

mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have

been identified. Multiple transcript variants encoding different isoforms have been described for this gene. (provided

by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108

Function: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular

carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site

located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to

modulate the action of the GABA receptor

Gene Wiki entry for DBI (Diazepam binding inhibitor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DBI gene promoter:
PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DBI promoter sequence

Search SABiosciences Chromatin IP Primers for DBI

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DBI

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q21 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q12-q21

DBI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBI gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P120124: view genomic region (about GC identifiers)

Start:	120,124,497 bp from pter	End:	120,130,126 bp from pter
Size:	5,630 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108 (See protein sequence)

Recommended Name: Acyl-CoA-binding protein

Size: 87 amino acids; 10044 Da

Subunit: Monomer

Subcellular location: Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding

2 PDB 3D structures from and Proteopedia for DBI:

2CB8 (3D)

2FJ9 (3D)

Secondary accessions: B8ZWD2 B8ZWD6 B8ZWD7 P08869 Q4VWZ6 Q53SQ7 Q6IB48 Q9UCI8

Alternative promoter usage, Alternative splicing: 6 isoforms: P07108-1 P07108-2 P07108-3 P07108-4 P07108-5 P07108-6 (Predominantly expressed in adipose tissue and hippocampus)

Explore the universe of human proteins at neXtProt for DBI: NX_P07108

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P07108

DBI Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (7 alternative transcripts):

NP_001073331.1 NP_001073332.1 NP_001171488.1 NP_001171512.1 NP_001171513.1 NP_001171514.1 NP_065438.1

ENSEMBL proteins:

ENSP00000348116 ENSP00000386486 ENSP00000311117 ENSP00000376815 ENSP00000442917

ENSP00000440698 ENSP00000439012

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: DBI OriGene Protein Over-expression Lysate: DBI OriGene Custom Protein Services for DBI
	GenScript Custom Purified and Recombinant Proteins Services for DBI
	Novus Biologicals DBI Proteins Novus Biologicals DBI Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for DBI
	Uscn Proteins for DBI

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005794	Golgi apparatus	IEA	--

DBI for ontologies About GeneDecksing

DBI Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies OriGene Custom Antibody Services for DBI
	GenScript Custom Superior Antibodies Services for DBI
	Novus Biologicals DBI Antibodies
	Search for Antibodies for DBI at Abcam
	Uscn Antibodies for DBI
	ThermoFisher Antibodies for DBI

Assay Products for DBI:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DBI
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DBI

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DBI for domains About GeneDecksing

3 InterPro domains/families:

IPR022408 Acyl-CoA-binding_prot_CS

IPR014352 FERM/acyl-CoA-bd_prot_3-hlx

IPR000582 Acyl-CoA-binding_protein

Graphical View of Domain Structure for InterPro Entry P07108

ProtoNet protein and cluster: P07108

1 Blocks protein family: IPB000582 Acyl-coA-binding protein

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108

Similarity: Belongs to the ACBP family

Similarity: Contains 1 ACB (acyl-CoA-binding) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108

Function: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular

carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site

located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to

modulate the action of the GABA receptor

Genatlas biochemistry entry for DBI:

diazepam binding inhibitor (?GABA receptor modulator),endozepine

miRNA Products:		OriGene 3'-UTR Clone (see all 3): DBI Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DBI
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate DBI (see all 20):
		hsa-miR-548j hsa-miR-3910 hsa-miR-495 hsa-miR-548i hsa-miR-606 hsa-miR-7-1* hsa-miR-548x hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DBI 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DBI (see all 7) OriGene shRNA RFP: DBI OriGene siRNA: DBI
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DBI

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DBI

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DBI (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DBI (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): DBI (NM_020548)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBI
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBI

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DBI
		Search LifeMap BioReagents cell lines for DBI

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBI

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000062	fatty-acyl-CoA binding	IEA	--
GO:0008289	lipid binding	IEA	--
GO:0030156	benzodiazepine receptor binding	TAS	3020548

DBI for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Dbi^tm1Smdp for DBI
     6 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dbi):

behavior/neurological	growth/size	homeostasis/metabolism	integument	liver/biliary system
mortality/aging

DBI for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PPAR signaling pathway

PPAR signaling pathway

1.00

Benzodiazepine Pathway, Pharmacodynamics

Benzodiazepine Pathway, Pharmacodynamics

1.00

Regulation of Cholesterol Biosynthesis by SREBP (SREBF)

SREBP signalling

0.46

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for DBI

SREBP signalling

1 PharmGKB Pathway for DBI

Benzodiazepine Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for DBI):

PPAR signaling pathway

DBI for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DBI

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/14 Interacting proteins for DBI (P07108^{2, 3} ENSP00000311117⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RAD23A	P54725²^,³, ENSP00000321365⁴	MINT-8267951 I2D: score=2 STRING: ENSP00000321365
DUSP23	Q9BVJ7²^,³	MINT-8254611 I2D: score=2
GSK3B	P49841²^,³	MINT-8257064 I2D: score=2
MAP1LC3B	Q9GZQ8²^,³	MINT-8259532 I2D: score=2
NSFL1C	Q9UNZ2²^,³	MINT-8264204 I2D: score=2

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001942	hair follicle development	IEA	--
GO:0006641	triglyceride metabolic process	IEA	--
GO:0006810	transport	IEA	--
GO:0043588	skin development	IEA	--

DBI for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DBI for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DBI

10/32 HMDB Compounds for DBI (see all 32) About this table

Compound	Synonyms	CAS #	PubMed Ids
(2E)-Decenoyl-CoA	(E)-S-2-decenoate Coenzyme A (see all 15)	10018-95-8	--
(2E)-Dodecenoyl-CoA	2-trans-Dodecenoyl-Coenzyme A (see all 4)	1066-12-2	--
(2E)-Hexadecenoyl-CoA	trans-2-Hexadecenoyl-CoA (see all 4)	4460-95-1	--
(2E)-Octenoyl-CoA	(E)-S-2-octenoate Coenzyme A (see all 16)	10018-94-7	--
(2E)-Tetradecenoyl-CoA	(2E)-Tetradecenoyl-Coenzyme A (see all 8)	38795-33-4	--
2-Methylbutyryl-CoA	2-methylbutanoyl-CoA (see all 11)	6712-02-3	--
2-Methylhexanoyl-CoA	2-Methylhexanoyl-CoEnzyme A (see all 5)	--	--
3Z-dodecenoyl-CoA	S-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)	2152-91-2	--
Acetyl-CoA	S-Acetyl coenzyme A (see all 13)	72-89-9	--
Acrylyl-CoA	Acryloyl coenzyme A (see all 14)	5776-58-9	--

2 DrugBank Compounds for DBI About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Coenzyme A	--	85-61-0	target	--	17139284 17016423 10592235
Hexadecanal	16-Hexadecanal (see all 7)	629-80-1	target	--	17139284 17016423 10592235

9 Novoseek chemical compound relationships for DBI gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
acyl-coa	90.8	101	7702576 (6), 17044054 (4), 14527695 (3), 9022045 (2) (see all 41)
diazepam	62.9	9	9022045 (1), 9817074 (1), 7789980 (1), 14755437 (1) (see all 7)
fatty acid	54	10	19088433 (1), 10721891 (1), 17044054 (1), 2266965 (1) (see all 8)
benzodiazepine	50.5	6	9022045 (1), 9817074 (1), 16908521 (1), 8634149 (1)
sterol	46.3	4	16055366 (1), 10412765 (1), 12518025 (1), 10331663 (1)
lipid	37.6	12	20511713 (2), 12479581 (2), 15102341 (1), 18242688 (1) (see all 7)
cholesterol	2.9	7	12518025 (4), 19088433 (1), 9219899 (1), 20511713 (1)
hydrogen	0	2	10966822 (2)
gaba	0	4	9022045 (1), 14755437 (1)

Search CenterWatch for drugs/clinical trials and news about DBI / ACBP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DBI gene (7 alternative transcripts):

NM_001079862.1 NM_001079863.1 NM_001178017.1 NM_001178041.1 NM_001178042.1 NM_001178043.1 NM_020548.6

Unigene Cluster for DBI:

Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)

Hs.78888 [show with all ESTs]

Unigene Representative Sequence: BQ278412

10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000355857(uc002tlv.3) ENST00000492375 ENST00000409094 ENST00000311521(uc002tlw.3 uc010yyo.2)

ENST00000460901 ENST00000393103(uc002tlx.3) ENST00000475783 ENST00000535617(uc010yyj.2 uc010yyk.2)

ENST00000542275(uc021vnj.1) ENST00000535757(uc010yyi.2 uc010yyh.2 uc010yyl.2 uc010yym.2 uc010yyn.2)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): DBI Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DBI
		8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate DBI (see all 20):
		hsa-miR-548j hsa-miR-3910 hsa-miR-495 hsa-miR-548i hsa-miR-606 hsa-miR-7-1* hsa-miR-548x hsa-miR-548d-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DBI 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DBI (see all 7) OriGene shRNA RFP: DBI OriGene siRNA: DBI
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DBI

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DBI (see all 10) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DBI (see all 7) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 7): DBI (NM_020548)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBI
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBI

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DBI Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DBI
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DBI
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DBI

Additional cDNA sequence:

AM000001.1 BC006466.1 BC062996.1 CR456956.1 FM213122.1 FM213123.1 FM213124.1 FM213125.1

FM213126.1 FM213127.1 FM213128.1 FM213129.1 FM213130.1 FM213131.1 FM213132.1 M14200.1

M15887.1

18 DOTS entries:

DT.101956652 DT.449558 DT.92450395 DT.100797944 DT.121021264 DT.100725618 DT.95160934 DT.100038465

DT.100797941 DT.65287453 DT.100797929 DT.121021232 DT.121021245 DT.121021246 DT.95160922 DT.97855414

DT.121021256 DT.92450393

24/460 AceView cDNA sequences (see all 460):

BE311986 CB156646 BC006466 BE763933 BU729387 BQ648466 CA395869 N27298

BG252719 AA306540 W57985 BC062996 BM760243 BU787569 BM509960 AU102640

BQ645457 BM005729 CB149770 AI355375 AA401480 CD365144 BQ940531 AA316877

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DBI (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e
SP1:									-		-		-				-				-
SP2:									-		-		-				-				-
SP3:													-				-				-
SP4:									-		-		-		-		-				-
SP5:													-		-		-				-

ECgene alternative splicing isoforms for DBI

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DBI expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTTTATCCT

About this image

DBI expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DBI Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DBI

SOURCE GeneReport for Unigene cluster: Hs.78888

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108

Tissue specificity: Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level

in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart

SABiosciences Custom PCR Arrays for DBI

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DBI Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DBI
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DBI
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DBI

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBI

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DBI gene from 9/29 species (see all 29) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DBI¹	diazepam binding inhibitor (GABA receptor modulator, more	74.03(n) 75.58(a)		395263 NM_204576.1 NP_989907.1
lizard (Anolis carolinensis)	Reptilia	DBI⁶	--	80(a)	1 ↔ 1	GL343497.1(169418-174828)
African clawed frog (Xenopus laevis)	Amphibia	Xl.2125²	Xenopus laevis transcribed sequence with moderate similarity more	78.34(n)		BI442833.1
zebrafish (Danio rerio)	Actinopterygii	zgc77734²	hypothetical protein MGC77734	73.78(n)		393831 BC062845.1
fruit fly (Drosophila melanogaster)	Insecta	Dbi¹	Diazepam-binding inhibitor	58.44(n) 53.09(a)		38784 NM_168192.2 NP_729218.1
worm (Caenorhabditis elegans)	Secernentea	acbp-1¹	Protein ACBP-1	63.79(n) 56.79(a)		172071 NM_059011.4 NP_491412.1
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	ACB1(YGR037C)⁴ ACB1¹	Acyl-CoA-binding protein, transports newly synthesized more⁴ Acb1p¹	58.33(n)¹ 51.25(a)¹		7(559994-559731)⁴ 852925^{1, 4} NP_011551.3¹ NP_011551.1⁴
thale cress (Arabidopsis thaliana)	eudicotyledons	ACBP6⁶	acyl-CoA-binding protein 6	43(a)	1 → many	1(11410875-11412204)
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	acyl CoA binding protein, putative, expressed (see all 3)	45(a) 43(a) (see all 3)	many ↔ many many ↔ many (see all 3)	8(3697315-3699556) 6(859906-861570)

ENSEMBL Gene Tree for DBI (if available)
TreeFam Gene Tree for DBI (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DBI gene

ACBD5² ACBD7² ACBD4²

7 SIMAP similar genes for DBI using alignment to 4 protein entries: ACBP_HUMAN (see all proteins):

BRL ACBD7 ACBD4 HCA64 PECI ECI2

ACBD5

DBI for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for DBI
PGOHUM00000248973 PGOHUM00000240066 PGOHUM00000235295 PGOHUM00000243260 PGOHUM00000249578

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11123516^1,2	C,A,H,	--	120122538(+)	`gcccaC/Gatttc`	2	--	us2k¹ int¹		4		NA WA EA	362
rs1900304^1,2	C,F,A,H,	--	120122540(+)	`ccacaT/Gttcca`	2	--	int¹ us2k¹		8		EA NS NA CSA WA	518
rs11692118^1,2	C,F,H	--	120122559(+)	`ggaggC/Ataagg`	6	--	us2k¹ int¹		1		NA	4
rs79158537^1,2	F,	--	120122610(+)	`AGCTGA/TGATTG`	6	--	int¹ us2k¹		3		WA NA EA	358
rs11123517^1,2	C,F,A,H,	--	120122664(+)	`cacgcG/Aaaaat`	6	--	int¹ us2k¹ tfbs³		9		NS EA NA WA	760
rs190309576^1,2		--	120122796(+)	`TTGACC/TGCAAA`	6	--	int¹ us2k¹		0	--	--	--	--
rs182577478^1,2		--	120122807(+)	`TCTGGC/TCCACA`	6	--	us2k¹ int¹		0	--	--	--	--
rs72831290^1,2	C,	--	120122916(+)	`TTTTCG/AAAGAA`	7	--	us2k¹ int¹		2		NA	122
rs11676928^1,2	C,F,H,	--	120123048(+)	`CCTATT/AGCATC`	7	--	us2k¹ int¹		18		NS EA NA WA	2344
rs78487555^1,2	C,	--	120123090(+)	`GACCTA/GCATTA`	7	--	us2k¹ int¹		2		NA	122

HapMap Linkage Disequilibrium report for DBI (120124497 - 120130126 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DBI: --
Human Gene Mutation Database (HGMD): DBI

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DBI

DNA2.0 Custom Variant and Variant Library Synthesis for DBI

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DBI for disorders           About GeneDecksing

OMIM gene information: 125950    OMIM disorders: --

19 diseases for DBI:    About MalaCards

pancreatitis insulin resistance drug dependence anxiety disorder

zellweger syndrome hepatic encephalopathy alcoholic pancreatitis duodenitis

prostate adenocarcinoma alcoholism hepatocellular carcinoma ovarian cancer

adenocarcinoma hepatitis cholesterol prostatitis

schizophrenia melanoma carcinoma

2 Novoseek disease relationships for DBI gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver	30.5	1	12518025 (1)
insulin resistance	0	1	17262885 (1)

Human Genome Epidemiology (HuGE) Navigator: DBI (16 documents)

Export disorders for DBI gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DBI gene, integrated from 9 sources (see all 120):
(articles sorted by number of sources associating them with DBI)

Utopia: connect your pdf to the dynamic
world of online information

High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. (PubMed id 17044054)^{1, 2, 9} Taskinen J.P.... Wierenga R.K. (2007)
Identification of new acyl-CoA binding protein transcripts in human and mouse. (PubMed id 16055366)^{1, 2, 9} Nitz I.... Burwinkel B. (2005)
Specific regulation of low-abundance transcript varia nts encoding human Acyl-CoA binding protein (ACBP) isoforms. (PubMed id 20345851)^{1, 2} Nitz I....DAPring F. (2011)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
The characterization of two diazepam binding inhibitor (DBI) transcripts in humans. (PubMed id 7534063)^{1, 2} Kolmer M.... Alho H. (1995)
New chromosomal mapping assignments for argininosucci nate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene. (PubMed id 1440058)^{1, 3} Todd S. and Naylor S.L. (1992)
Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand. (PubMed id 2881742)^{1, 2} Webb N.R....Lee D.C. (1987)
Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma- aminobutyric acid type A receptor. (PubMed id 3020548)^{1, 2} Gray P.W.... Costa E. (1986)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1622	HGNC: 2690	AceView: DBI	Ensembl:ENSG00000155368	euGenes: HUgn1622
ECgene: DBI	Kegg: 1622	H-InvDB: DBI

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DBI	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DBI	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for DBI gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for DBI gene:
Search GeneIP for patents involving DBI

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	Browse OriGene Antibodies		OriGene shRNA RFP for DBI
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DBI		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DBI
	OriGene Protein Over-expression Lysate for DBI		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DBI		OriGene 3'-UTR Clone for DBI
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DBI		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DBI
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for DBI		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for DBI		OriGene Custom Protein Services for DBI
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DBI
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DBI
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DBI
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DBI
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DBI
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DBI

	GenScript Custom Purified and Recombinant Proteins Services for DBI		GenScript cDNA clones with any tag delivered in your preferred vector for DBI
	GenScript Custom Assay Services for DBI		GenScript Custom Superior Antibodies Services for DBI
	GenScript Custom overexpressing Cell Line Services for DBI		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in DBI promoter
	Search Chromatin IP Primers for DBI
	RT² qPCR Primer Assay in human, mouse, rat DBI
	Search GNC Networks for DBI
	SABiosciences Custom PCR Arrays for DBI

Search Tocris compounds for DBI

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DBI antibodies
	DBI proteins
	DBI lysates

	Search for Antibodies for DBI at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for DBI
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for DBI

DBI Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DBI

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBI

	SwitchGear 3'UTR luciferase reporter plasmids for DBI
	SwitchGear Promoter luciferase reporter plasmids for DBI

ThermoFisher Antibodies for DBI

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBI

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes DBI gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

DBI Gene

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA...

Aliases
for DBI gene

Summaries
for DBI gene

Genomic Views
for DBI gene

Proteins
for DBI gene

Protein Domains /
Families
for DBI gene

Function
for DBI gene

Pathways & Interactions
for DBI gene

Drugs & Compounds
for DBI gene

Transcripts
for DBI gene

Expression
for DBI gene

Orthologs
for DBI gene

Paralogs
for DBI gene

Genomic Variants
for DBI gene

Disorders / Diseases
for DBI gene

Publications
for DBI gene

External Searches for DBI gene

Genome Databases showing DBI gene

Other Databases showing DBI gene

Specialized Databases showing DBI gene

Intellectual Property
for DBI gene

Products
for DBI gene

View Random Gene

Advanced Search

Export list of displayed genes

DBI Gene

diazepam binding inhibitor (GABA receptor modulator, acyl-CoA...

Aliasesfor DBI gene

Summariesfor DBI gene

Genomic Viewsfor DBI gene

Proteinsfor DBI gene

Protein Domains /Familiesfor DBI gene

Functionfor DBI gene

Pathways & Interactionsfor DBI gene

Drugs & Compoundsfor DBI gene

Transcriptsfor DBI gene

Expression for DBI gene

Orthologsfor DBI gene

Paralogsfor DBI gene

Genomic Variantsfor DBI gene

Disorders / Diseasesfor DBI gene

Publicationsfor DBI gene

External Searches for DBI gene

Genome Databases showing DBI gene

Other Databases showing DBI gene

Specialized Databases showing DBI gene

Intellectual Propertyfor DBI gene

Productsfor DBI gene

View Random Gene

Aliases
for DBI gene

Summaries
for DBI gene

Genomic Views
for DBI gene

Proteins
for DBI gene

Protein Domains /
Families
for DBI gene

Function
for DBI gene

Pathways & Interactions
for DBI gene

Drugs & Compounds
for DBI gene

Transcripts
for DBI gene

Expression
for DBI gene

Orthologs
for DBI gene

Paralogs
for DBI gene

Genomic Variants
for DBI gene

Disorders / Diseases
for DBI gene

Publications
for DBI gene

Intellectual Property
for DBI gene

Products
for DBI gene