Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DBI Gene

protein-coding   GIFtS: 69
GCID: GC02P120124

Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA...

(Previous names: diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding
Protein)1 2
     CCK-RP2
Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-Coenzyme A
Binding Protein)1 2
     Acyl Coenzyme A Binding Protein2
endozepine1 2     Acyl-CoA-Binding Protein2
Diazepam-Binding Inhibitor2 3     Acyl-Coenzyme A Binding Domain Containing 12
ACBP2 3     Cholecystokinin-Releasing Peptide, Trypsin-Sensitive2
EP2 3     GABA Receptor Modulator2
ACBD12     Endozepine3

External Ids:    HGNC: 26901   Entrez Gene: 16222   Ensembl: ENSG000001553687   OMIM: 1259505   UniProtKB: P071083   
ORGUL members:         

Export aliases for DBI gene to outside databases

Previous GC identifers: GC02P117330 GC02P118045 GC02P120031 GC02P120219 GC02P120220 GC02P119840 GC02P112449


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DBI Gene:
This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid
metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at
type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to
mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the
hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also
known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin,
in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes
located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms
have been described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DBI Gene:
DBI (diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)) is a protein-coding gene. Diseases associated with DBI include alcoholic pancreatitis, and hepatic encephalopathy. GO annotations related to this gene include lipid binding and benzodiazepine receptor binding. An important paralog of this gene is ACBD7.

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108
Function: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an
intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD)
recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a
neuropeptide to modulate the action of the GABA receptor

Gene Wiki entry for DBI (Diazepam binding inhibitor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005403.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the DBI gene promoter:
         PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDBI promoter sequence
   Search Chromatin IP Primers for DBI

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DBI


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12-q21   Ensembl cytogenetic band:  2q14.2   HGNC cytogenetic band: 2q12-q21

DBI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBI gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P120124:  view genomic region     (about GC identifiers)

Start:
120,124,497 bp from pter      End:
120,130,126 bp from pter
Size:
5,630 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108 (See protein sequence)
Recommended Name: Acyl-CoA-binding protein  
Size: 87 amino acids; 10044 Da
Subunit: Monomer
2 PDB 3D structures from and Proteopedia for DBI:
2CB8 (3D)        2FJ9 (3D)    
Secondary accessions: B8ZWD2 B8ZWD6 B8ZWD7 P08869 Q4VWZ6 Q53SQ7 Q6IB48 Q9UCI8
Alternative promoter usage, Alternative splicing: 6 isoforms:  P07108-1   P07108-2   P07108-3   P07108-4   P07108-5   P07108-6   (Predominantly expressed in adipose tissue and hippocampus)

Explore the universe of human proteins at neXtProt for DBI: NX_P07108

Explore proteomics data for DBI at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys55, Lys77
  • Modification sites at PhosphoSitePlus

  • See DBI Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (11 alternative transcripts): 
    NP_001073331.1  NP_001073332.1  NP_001171488.1  NP_001171512.1  NP_001171513.1  NP_001171514.1  NP_001269562.1  NP_001269563.1  
    NP_001269564.1  NP_001269565.1  NP_065438.1  

    ENSEMBL proteins: 
     ENSP00000348116   ENSP00000386486   ENSP00000311117   ENSP00000376815   ENSP00000442917  
     ENSP00000440698   ENSP00000439012  

    DBI Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DBI
    OriGene Protein Over-expression Lysate for DBI
    OriGene MassSpec for DBI
    OriGene Custom Protein Services for DBI
    GenScript Custom Purified and Recombinant Proteins Services for DBI
    Novus Biologicals DBI Proteins
    Novus Biologicals DBI Lysates
    Sino Biological Recombinant Protein for DBI
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DBI
    Cloud-Clone Corp. Proteins for DBI

    DBI Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for DBI
    OriGene Custom Antibody Services for DBI
    Novus Biologicals DBI Antibodies
    Abcam antibodies for DBI
    Cloud-Clone Corp. Antibodies for DBI
    ThermoFisher Antibodies for DBI
    LSBio Antibodies in human, mouse, rat for DBI

    DBI Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DBI
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DBI
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DBI
    Cloud-Clone Corp. CLIAs for DBI


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR022408 Acyl-CoA-binding_prot_CS
     IPR014352 FERM/acyl-CoA-bd_prot_3-hlx
     IPR000582 Acyl-CoA-binding_protein

    Graphical View of Domain Structure for InterPro Entry P07108

    ProtoNet protein and cluster: P07108

    1 Blocks protein domain: IPB000582 Acyl-coA-binding protein

    UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108
    Similarity: Belongs to the ACBP family
    Similarity: Contains 1 ACB (acyl-CoA-binding) domain


    DBI for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACBP_HUMAN, P07108
    Function: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an
    intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD)
    recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a
    neuropeptide to modulate the action of the GABA receptor

         Genatlas biochemistry entry for DBI:
    diazepam binding inhibitor (?GABA receptor modulator),endozepine

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000062fatty-acyl-CoA binding IEA--
    GO:0008289lipid binding IEA--
    GO:0030156benzodiazepine receptor binding TAS3020548
         
    DBI for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Dbi):
     adipose tissue  behavior/neurological  growth/size/body  homeostasis/metabolism  integument 
     liver/biliary system  mortality/aging  normal 

    DBI for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DBI: Dbitm1Smdp Dbitm1Kier Dbitm2.2Smdp

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DBI
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DBI

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DBI
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DBI

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DBI using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DBI (see all 20):
    hsa-miR-548j hsa-miR-3910 hsa-miR-495 hsa-miR-548i hsa-miR-606 hsa-miR-7-1* hsa-miR-548x hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidDBI 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DBI
    Predesigned siRNA for gene silencing in human, mouse, rat DBI

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DBI

    Clone
    Products:
         
    OriGene clones in human, mouse for DBI (see all 32)
    OriGene ORF clones in mouse, rat for DBI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): DBI (NM_020548)
    Sino Biological Human cDNA Clone for DBI
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBI

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DBI
    Browse ESI BIO Cell Lines and PureStem Progenitors for DBI 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBI


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ACBP_HUMAN, P07108: Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand
    binding
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    golgi apparatus5
    cytosol3
    mitochondrion2
    nucleus2
    peroxisome2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--
    GO:0005783endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0070062extracellular vesicular exosome IDA--

    DBI for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DBI About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Cholesterol Biosynthesis by SREBP (SREBF)
    SREBP signalling0.31
    2PPAR signaling pathway
    PPAR signaling pathway
    3Benzodiazepine Pathway, Pharmacodynamics
    Benzodiazepine Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for DBI
        SREBP signalling


    1 PharmGKB Pathway for DBI
        Benzodiazepine Pathway, Pharmacodynamics

    1 Kegg Pathway  (Kegg details for DBI):
        PPAR signaling pathway


    DBI for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DBI
    Interactions:

        Search GeneGlobe Interaction Network for DBI

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for DBI (P071082, 3 ENSP000003111174) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAD23AP547252, 3, ENSP000003213654MINT-8267951 I2D: score=2 STRING: ENSP00000321365
    DUSP23Q9BVJ72, 3MINT-8254611 I2D: score=2 
    GSK3BP498412, 3MINT-8257064 I2D: score=2 
    MAP1LC3BQ9GZQ82, 3MINT-8259532 I2D: score=2 
    NSFL1CQ9UNZ22, 3MINT-8264204 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001942hair follicle development IEA--
    GO:0006641triglyceride metabolic process IEA--
    GO:0006810transport IEA--
    GO:0043588skin development ----

    DBI for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DBI (ACBP)

    Selected HMDB Compounds for DBI (see all 32)    About this table
    CompoundSynonyms CAS #PubMed Ids
    (2E)-Decenoyl-CoA(E)-S-2-decenoate Coenzyme A (see all 15)10018-95-8--
    (2E)-Dodecenoyl-CoA2-trans-Dodecenoyl-Coenzyme A (see all 4)1066-12-2--
    (2E)-Hexadecenoyl-CoAtrans-2-Hexadecenoyl-CoA (see all 4)4460-95-1--
    (2E)-Octenoyl-CoA(E)-S-2-octenoate Coenzyme A (see all 16)10018-94-7--
    (2E)-Tetradecenoyl-CoA(2E)-Tetradecenoyl-Coenzyme A (see all 8)38795-33-4--
    2-Methylbutyryl-CoA2-methylbutanoyl-CoA (see all 11)6712-02-3--
    2-Methylhexanoyl-CoA2-Methylhexanoyl-CoEnzyme A (see all 5)----
    3Z-dodecenoyl-CoAS-[2-[3-[[(2R)-4-[[[(2R,3R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-dodec-3-enethioate (see all 4)2152-91-2--
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Acrylyl-CoAAcryloyl coenzyme A (see all 14)5776-58-9--

    2 DrugBank Compounds for DBI    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Coenzyme A-- 85-61-0target--17139284 17016423 10592235
    Hexadecanal16-Hexadecanal (see all 7)629-80-1target--17139284 17016423 10592235

    9 Novoseek inferred chemical compound relationships for DBI gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acyl-coa 90.8 101 7702576 (6), 17044054 (4), 14527695 (3), 9022045 (2) (see all 41)
    diazepam 62.9 9 9022045 (1), 9817074 (1), 7789980 (1), 14755437 (1) (see all 7)
    fatty acid 54 10 19088433 (1), 10721891 (1), 17044054 (1), 2266965 (1) (see all 8)
    benzodiazepine 50.5 6 9022045 (1), 9817074 (1), 16908521 (1), 8634149 (1)
    sterol 46.3 4 16055366 (1), 10412765 (1), 12518025 (1), 10331663 (1)
    lipid 37.6 12 20511713 (2), 12479581 (2), 15102341 (1), 18242688 (1) (see all 7)
    cholesterol 2.9 7 12518025 (4), 19088433 (1), 9219899 (1), 20511713 (1)
    hydrogen 0 2 10966822 (2)
    gaba 0 4 9022045 (1), 14755437 (1)



    DBI for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DBI gene (11 alternative transcripts): 
    NM_001079862.2  NM_001079863.1  NM_001178017.1  NM_001178041.2  NM_001178042.2  NM_001178043.2  NM_001282633.1  NM_001282634.1  
    NM_001282635.1  NM_001282636.1  NM_020548.7  

    Unigene Cluster for DBI:

    Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
    Hs.78888  [show with all ESTs]
    Unigene Representative Sequence: BQ278412
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355857(uc002tlv.3) ENST00000492375 ENST00000409094 ENST00000311521(uc002tlw.3 uc010yyo.2)
    ENST00000460901 ENST00000393103(uc002tlx.3) ENST00000475783 ENST00000535617(uc010yyj.2 uc010yyk.2)
    ENST00000542275(uc021vnj.1) ENST00000535757(uc010yyi.2 uc010yyh.2 uc010yyl.2 uc010yym.2 uc010yyn.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DBI using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DBI (see all 20):
    hsa-miR-548j hsa-miR-3910 hsa-miR-495 hsa-miR-548i hsa-miR-606 hsa-miR-7-1* hsa-miR-548x hsa-miR-548d-5p
    SwitchGear 3'UTR luciferase reporter plasmidDBI 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DBI
    Predesigned siRNA for gene silencing in human, mouse, rat DBI
    Clone
    Products:
         
    OriGene clones in human, mouse for DBI (see all 32)
    OriGene ORF clones in mouse, rat for DBI
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 7): DBI (NM_020548)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DBI
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBI
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DBI
    OriGene qSTAR qPCR primer pairs in human, mouse for DBI
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBI
      QuantiTect SYBR Green Assays in human, mouse, rat DBI
      QuantiFast Probe-based Assays in human, mouse, rat DBI

    Additional mRNA sequence: 

    AM000001.1 BC006466.1 BC062996.1 CR456956.1 FM213122.1 FM213123.1 FM213124.1 FM213125.1 
    FM213126.1 FM213127.1 FM213128.1 FM213129.1 FM213130.1 FM213131.1 FM213132.1 M14200.1 
    M15887.1 

    18 DOTS entries:

    DT.101956652  DT.449558  DT.92450395  DT.100797944  DT.121021264  DT.100725618  DT.95160934  DT.100038465 
    DT.100797941  DT.65287453  DT.100797929  DT.121021232  DT.121021245  DT.121021246  DT.95160922  DT.97855414 
    DT.121021256  DT.92450393 

    Selected AceView cDNA sequences (see all 460):

    AL134498 BM663648 BQ921181 M14200 BQ648124 AW951430 N80938 CB115400 
    BM764994 AI241865 CB106858 H38184 CA426141 AI309996 H87336 AA335647 
    BU738062 AA377281 AA679856 CB156514 F01699 AA700003 AA557174 CB124252 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DBI (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
    SP1:                          -     -     -           -           -                                       
    SP2:                          -     -     -           -           -                                       
    SP3:                                      -           -           -                                       
    SP4:                          -     -     -     -     -           -                                       
    SP5:                                      -     -     -           -                                       


    ECgene alternative splicing isoforms for DBI

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DBI expression in normal human tissues (normalized intensities)      DBI embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTATCCT
    DBI Expression
    About this image


    DBI expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 9 entries
             Thalamus
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
    DBI Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DBI Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.78888

    UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108
    Tissue specificity: Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high
    level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart

        Custom PCR Arrays for DBI
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DBI
    OriGene qSTAR qPCR primer pairs in human, mouse for DBI
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBI
    QuantiTect SYBR Green Assays in human, mouse, rat DBI
    QuantiFast Probe-based Assays in human, mouse, rat DBI
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBI

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DBI gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dbi1 , 5 diazepam binding inhibitor1, 5 82.38(n)1
    78.16(a)1
      1 (52.65 cM)5
    131671  NM_007830.41  NP_031856.11 
     1201132805 
    chicken
    (Gallus gallus)
    Aves DBI1 diazepam binding inhibitor (GABA receptor modulator, more 74.71(n)
    75.86(a)
      395263  NM_204576.1  NP_989907.1 
    lizard
    (Anolis carolinensis)
    Reptilia DBI6
    diazepam binding inhibitor (GABA receptor modulato...
    80(a)
    1 ↔ 1
    GL343497.1(169418-174828)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.21252 Xenopus laevis transcribed sequence with moderate similarity more 78.34(n)    BI442833.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc777342 hypothetical protein MGC77734 73.78(n)   393831  BC062845.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dbi1 Diazepam-binding inhibitor 57.36(n)
    51.16(a)
      38784  NM_079228.3  NP_523952.2 
    worm
    (Caenorhabditis elegans)
    Secernentea acbp-11 acbp-1 63.41(n)
    56.1(a)
      172071  NM_059011.5  NP_491412.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ACB1(YGR037C)4
    ACB11
    Acyl-CoA-binding protein, transports newly synthesized more4
    ACB11
    57.61(n)1
    50.62(a)1
      7(559994-559731)4
    8529251, 4  NP_011551.31  NP_011551.14 
    corn
    (Zea mays)
    Liliopsida Zm.71562 Zea mays clone cr1n.pk0144.g12, mRNA sequence 72.93(n)    AF457947.1 


    ENSEMBL Gene Tree for DBI (if available)
    TreeFam Gene Tree for DBI (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DBI gene
    ACBD72  
    7 SIMAP similar genes for DBI using alignment to 4 protein entries:     ACBP_HUMAN (see all proteins):
    BRL    ACBD7    ACBD4    HCA64    PECI    ECI2
    ACBD5

    DBI for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for DBI
    PGOHUM00000248973 PGOHUM00000240066 PGOHUM00000235295 PGOHUM00000243260 PGOHUM00000249578


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DBI (see all 111)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs776001281,2
    C,F--120126271(+) CCAAGC/GCTGAT 7 -- int13Minor allele frequency- G:0.07WA NA EA 358
    rs1469694641,2
    --120126303(+) GGTTTC/TTTGGG 7 -- int10--------
    rs780341201,2
    F--120126342(+) TGTGCC/GTTCCT 7 -- int11Minor allele frequency- G:0.09WA 118
    rs101814961,2
    C,F,H--120126349(+) TCCTGA/GTGATA 7 -- int17Minor allele frequency- G:0.07NS EA WA CSA 524
    rs48497781,2
    H--120126475(+) TGAAAC/TATGGG 7 -- int14Minor allele frequency- T:0.00NS EA 416
    rs1149719711,2
    F--120126601(+) TTTCCG/ACAGTA 7 -- int11Minor allele frequency- A:0.03WA 118
    rs1378975781,2
    --120126669(+) AGTACA/CCAGAA 7 -- int10--------
    rs37696641,2
    C,F,H--120126749(-) ACCTTC/TGCCAT 7 -- int14Minor allele frequency- T:0.19NA WA EA 360
    rs37696631,2
    C,F,A,H--120126753(-) ACTCAC/TCTTCG 7 -- int18Minor allele frequency- T:0.10NS EA NA WA 742
    rs37696621,2
    C,F,A,H--120126757(-) TAAAAC/TTCACC 7 -- int19Minor allele frequency- T:0.14NS EA NA CSA WA 648

    HapMap Linkage Disequilibrium report for DBI (120124497 - 120130126 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DBI:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508862CNV Insertion20534489
    nsv459119CNV Gain19166990
    nsv874960CNV Gain21882294

    Human Gene Mutation Database (HGMD): DBI
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DBI
    DNA2.0 Custom Variant and Variant Library Synthesis for DBI

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 125950    OMIM disorders: --

    20 diseases for DBI:    About MalaCards
    alcoholic pancreatitis    hepatic encephalopathy    drug dependence    zellweger syndrome
    anxiety disorder    pancreatitis    prostate adenocarcinoma    duodenitis
    insulin resistance    type 1 diabetes    schizophrenia    ovarian cancer
    adenocarcinoma    hepatocellular carcinoma    obesity    melanoma
    hepatitis    prostatitis    malaria    cerebritis

    2 diseases from the University of Copenhagen DISEASES database for DBI:
    Withdrawal disorder     Hepatic encephalopathy

    DBI for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DBI gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fatty liver 30.5 1 12518025 (1)
    insulin resistance 0 1 17262885 (1)

    Genetic Association Database (GAD): DBI
    Human Genome Epidemiology (HuGE) Navigator: DBI (16 documents)

    Export disorders for DBI gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DBI gene, integrated from 10 sources (see all 127):
    (articles sorted by number of sources associating them with DBI)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. (PubMed id 17044054)1, 2, 9 Taskinen J.P.... Wierenga R.K. (Proteins 2007)
    2. Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations. (PubMed id 17262885)1, 4, 9 Fisher E....DAPring F. (amp 2007)
    3. Identification of new acyl-CoA binding protein transcripts in human and mouse. (PubMed id 16055366)1, 2, 9 Nitz I.... Burwinkel B. (Int. J. Biochem. Cell Biol. 2005)
    4. Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms. (PubMed id 20345851)1, 2 Nitz I.... Doring F. (J. Cell. Mol. Med. 2011)
    5. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
    6. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (BMC Biol. 2009)
    7. Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacks. (PubMed id 16904689)1, 4 Thoeringer C.K....Keck M.E. (J Psychiatr Res 2007)
    8. Candidate gene association study of type 2 diabetes in a nested case-control study of the EPIC-Potsdam cohort - role of fat assimilation. (PubMed id 17266179)1, 4 Fisher E....DAPring F. (amp 2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1622 HGNC: 2690 AceView: DBI Ensembl:ENSG00000155368 euGenes: HUgn1622
    ECgene: DBI Kegg: 1622 H-InvDB: DBI

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DBI Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DBI Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DBI gene:
    Search GeneIP for patents involving DBI

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DBI   OriGene RNAi products in human, mouse, rat for DBI  
     OriGene qPCR primer pairs and template standards for DBI   OriGene Protein Over-expression Lysate for DBI  
     OriGene MassSpec something-or-other for DBI   OriGene clones in human, mouse for DBI  
     OriGene qSTAR qPCR primer pairs in human, mouse for DBI   OriGene Purified Protein for DBI  
     OriGene ORF clones in mouse, rat for DBI   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DBI   OriGene Custom Protein Services for DBI  

     
     
     Block miRNA regulation of human, mouse, rat DBI using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DBI
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DBI Predesigned siRNA for gene silencing in human, mouse, rat DBI
     QuantiFast Probe-based Assays in human, mouse, rat DBI QuantiTect SYBR Green Assays in human, mouse, rat DBI
     Custom PCR Arrays for DBI Search Chromatin IP Primers for DBI
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBI  Search GeneGlobe Interaction Network for DBI
     Regulatory tfbs in DBI promoter
     GenScript Custom Purified and Recombinant Proteins Services for DBI GenScript cDNA clones with any tag delivered in your preferred vector for DBI
     GenScript Custom Assay Services for DBI GenScript Custom overexpressing Cell Line Services for DBI
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DBI (ACBP)
     Proteins for DBI
     Browse Sino Biological Cell Lysates
     cDNA Clones for DBI
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DBI antibodies
     DBI proteins
     DBI lysates
     Antibodies for DBI
     See all of Abcam's Antibodies, Kits and Proteins for DBI
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DBI
     Proteins for DBI
     Antibodies for DBI
     ELISAs for DBI
     CLIAs for DBI



     Browse ESI BIO Cell Lines and PureStem Progenitors for DBI
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBI
     SwitchGear 3'UTR luciferase reporter plasmids for DBI
     SwitchGear Promoter luciferase reporter plasmids for DBI
     ThermoFisher Antibodies for DBI
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBI
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DBI
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DBI
     LSBio Antibodies in human, mouse, rat for DBI
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DBI gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4