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DBI Gene

protein-coding GIFtS: 68

GC02P119840

diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ACBD1 ^¹, ²
ACBP ^¹, ², ³
CCK-RP ^²
EP ^², ³
Endozepine ^³
MGC70414 ^²
endozepine ^²

Descriptions
Diazepam-binding inhibitor ^³
GABA receptor modulator ^²
acyl coenzyme A binding protein ^²
acyl-Coenzyme A binding domain containing 1 ^²
cholecystokinin-releasing peptide, trypsin-sensitive ^²
diazepam binding inhibitor ^²
diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein) ^²

External Ids
HGNC: 2690¹
Entrez Gene: 1622²
UniProtKB: P07108³
Ensembl: ENSG00000155368⁷

Search outside databases for aliases for DBI gene

Previous GC identifers: GC02P117330 GC02P118045 GC02P120031 GC02P120219 GC02P120220

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DBI:

This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is

involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which

modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain

synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain

consisting of seven contiguous residues that constitute the hydrophobic binding site for medium-

and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the

feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in

addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three

pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants

encoding different isoforms have been described for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108

Function: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as

an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the

benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore

possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor

Gene Wiki entry for DBI (Diazepam_binding_inhibitor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DBI gene

Entrez Gene cytogenetic band: 2q12-q21 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q12-q21

DBI Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P119840: (about GC identifiers)

Start:	119,840,974 bp from pter
End:	119,846,592 bp from pter
Size:	5,619 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_022135.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108 (See protein sequence)

Recommended Name: Acyl-CoA-binding protein

Size: 87 amino acids; 10044 Da

Subunit: Monomer

PDB structure from and Proteopedia :

2CB8 (3D)

2FJ9 (3D)

Secondary accessions: P08869 Q53SQ7 Q6IB48 Q9UCI8

Alternative splicing: 2 isoforms: P07108-1 P07108-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001073331.1 NP_001073332.1 NP_065438.1

ENSEMBL proteins:

ENSP00000348116 ENSP00000386003 ENSP00000311117 ENSP00000386486 ENSP00000376815

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Diazepam Binding Inhibitor)
	Human Recombinant Proteins from Abnova (DBI)

OriGene Purified Recombinant Human Protein: DBI

Antibodies for DBI:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DBI
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (Diazepam Binding Inhibitor), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DBI)
	Novus Biologicals Antibody for DBI

Assays for DBI:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P07108

ProtoNet protein and cluster: P07108

1 Blocks protein family: IPB000582 Acyl-coA-binding protein

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108

Similarity: Belongs to the ACBP family

Similarity: Contains 1 ACB (acyl-CoA-binding) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DBI)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DBI)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_020548

Applied Biosystems Silencer® siRNAs for DBI

Sigma-Aldrich siRNA for DBI

Sigma-Aldrich shRNA for DBI

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DBI
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001079862
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001079862
untagged cDNA clones in CMV expression vector (see all 3): NM_001079862

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_020548

UniProtKB/Swiss-Prot: ACBP_HUMAN, P07108

Function: Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as

an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the

benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore

possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor

Genatlas biochemistry entry for DBI:

diazepam binding inhibitor (?GABA receptor modulator),endozepine

1 MGI phenotypic allele

for Dbi (no phenotypes)

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000062	acyl-CoA binding	IEA	--
GO:0008289	lipid binding	IEA	--
GO:0030156	benzodiazepine receptor binding	TAS	3020548

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

5/21 Interacting proteins for DBI (P07108² ENSP00000311117³) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PPCDC	Q96CD2²	MINT-63420
TSPO	ENSP00000338004³	STRING (score=.914)
GH1	ENSP00000312673³	STRING (score=.899)
HTR2C	ENSP00000276198³	STRING (score=.899)
IRS1	ENSP00000304895³	STRING (score=.899)

About this table

1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006810	transport	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DBI
7 Novoseek chemical compound relationships for DBI gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
acyl-coa	90.78	98	7702576 (6), 17044054 (4), 14527695 (3), 9022045 (2) (see all 39)
fatty acid	53.98	9	19088433 (1), 10721891 (1), 17044054 (1), 2266965 (1) (see all 7)
benzodiazepine	51.54	6	9022045 (1), 9817074 (1), 16908521 (1), 8634149 (1)
sterol	47.97	4	16055366 (1), 10412765 (1), 12518025 (1), 10331663 (1)
lipid	37.70	10	12479581 (2), 15102341 (1), 18242688 (1), 16055366 (1) (see all 6)
hydrogen	0.00	2	10966822 (2)
cholesterol	0.00	6	12518025 (4), 19088433 (1), 9219899 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DBI)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DBI)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_020548

Sigma-Aldrich siRNA for DBI

Sigma-Aldrich shRNA for DBI

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001079862 NM_001079863 NM_020548

REFSEQ mRNAs for DBI gene (3 alternative transcripts):

NM_001079862.1 NM_001079863.1 NM_020548.5

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001079862 NM_001079863 NM_020548

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001079862
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001079862
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001079862

Additional cDNA sequence:

AM000001.1 BC006466.1 BC062996.1 CR456956.1 FM213122.1 FM213123.1 FM213124.1 FM213125.1

FM213126.1 FM213127.1 FM213128.1 FM213129.1 FM213130.1 FM213131.1 FM213132.1 M14200.1

M15887.1

18 DOTS entries:

DT.101956652 DT.449558 DT.92450395 DT.100797944 DT.121021264 DT.100725618 DT.95160934 DT.100038465

DT.100797941 DT.65287453 DT.100797929 DT.121021232 DT.121021245 DT.121021246 DT.95160922 DT.97855414

DT.121021256 DT.92450393

24/460 AceView cDNA sequences (see all 460 ):

CA426141 AA400296 AA978357 BP371076 H87336 AI309996 BI825918 CF527852

AA401480 CB120064 CD677422 BQ648309 AW327842 CB106011 CB119098 BG031972

AV715821 BM772690 AA355351 BQ648466 BQ940531 AI242184 AA378453 CB124252

highest scoring ESTs for DBI:

AA070950 AA070951 AA099590 AA165593 AA229022 AA229711 AA229737 AA230067 AA306540 AA313190

Unigene Cluster for DBI:

Diazepam binding inhibitor (GABA receptor modulator, acyl-Coenzyme A binding protein)

Hs.78888 [show with all ESTs]

Unigene Representative Sequence: BQ278412

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DBI (see all 8 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	·	2c	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d	·	7e
SP1:									-		-		-				-				-
SP2:									-		-		-				-				-
SP3:													-				-				-
SP4:									-		-		-		-		-				-
SP5:													-		-		-				-

About this scheme

ECgene alternative splicing isoforms for DBI

5 Ensembl transcripts including schematic representations:

ENST00000355857 ENST00000401684 ENST00000311521 ENST00000409094 ENST00000393103

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DBI expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DBI

¹ / ² / ³

7 probe-sets matching DBI gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
37692_at²^{, 3}	U95-A	2	1.00	0.94	1.00	1.00	AI557240	0.80	1.00	0.91	1
211070_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC006466	0.80	1.00	0.91	1
202428_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_020548	0.60	1.00	0.82	1
209389_x_at²^{, 3}	U133-A	2	1.00	0.95	--	--	M15887	0.80	1.00	0.91	1
211070_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
202428_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209389_x_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

GeneDecks DBI for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTTTATCCT

SOURCE GeneReport for Unigene cluster: Hs.78888
Expression variation in blood from EXPOLDB for DBI

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DBI gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DBI¹	--	diazepam binding inhibitor (GABA receptor modulator, more	89.15(n) 82.56(a)	476115 XM_844244.1 XP_849337.1
chimpanzee (Pan troglodytes)	DBI¹	--	diazepam binding inhibitor (GABA receptor modulator, more	99.36(n) 98.08(a)	459574 XM_001156427.1 XP_001156427.1
cow (Bos taurus)	DBI¹	--	diazepam binding inhibitor (GABA receptor modulator, more	90.31(n) 90.7(a)	768330 XM_864209.1 XP_869302.1
rat (Rattus norvegicus)	Dbi¹	--	diazepam binding inhibitor (GABA receptor modulator, more	81.4(n) 75.58(a)	25045 NM_031853.3 NP_114054.1
mouse (Mus musculus)	Dbi^{1, 5}	1⁵	diazepam binding inhibitor^{1, 5}	79.21(n)¹ 73.12(a)¹	13167¹ NM_001037999.1¹ NP_001033088.1¹ AA068307⁵ AF220221⁵ (see all 20)

About this table Species with no ortholog for DBI

ENSEMBL Gene Tree for DBI

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DBI gene

ACBD7²

Pseudogenes

6 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/34 NCBI SNPs in DBI are shown (see all 34 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 61)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2289948^1,2	A,C,F,H	119846668(-)	`CACTAC/GCAGAG`	3	--	ng3¹		13		EA NA EU WA	2558
	rs2289946^1,2	A,C,F,H	119846807(-)	`TCGGCG/ATGGCT`	3	--	ng3¹		7		NA EU EA WA	558
	rs2289947^1,2	A,C,F	119846731(-)	`ACCTTA/GGGCCA`	3	--	ng3¹		3		EA NA	1678
	rs8192506^1,2	C,F,H	119846311(+)	`ATGCCA/GTGAAA`	3	M/V	mis¹		11		EU EA WA NA	980
	rs8192507^1,2	C,F,H	119846356(+)	`AATACG/AGGATA`	3	R/G	mis¹ ese³		5		EU EA WA NA	484
	rs2289944^1,2	C,F,H	119846861(-)	`TCCCCG/ATCAGA`	3	--	ng3¹		8		EA NA EU WA	2062
	rs6741823^1,2	A,C	119847082(+)	`CTGCAA/GGGAGC`	3	--	ng3¹		0	--	--	--	--
	rs8192508^1,2	H	119846524(+)	`TAAAAC/TGATTA`	3	--	ut3¹		4		EU EA WA	416
	rs1050698^1,2	F	119846492(+)	`TGCTCA/CCCATA`	3	--	ut3¹ ese³		1		MN	184
	rs3769662^1,2	A,C,F,H	119843227(-)	`TAAAAC/TTCACC`	3	--	int¹		3		EU EA	280

About this table

HapMap Linkage Disequilibrium images for DBI (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 125950

2 Novoseek disease relationships for DBI gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fatty liver	33.53	1	12518025 (1)
insulin resistance	0.00	1	17262885 (1)

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1 PharmGKB disease relationship for DBI gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Human Genome Epidemiology Navigator: DBI (7 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/98 PubMed articles for DBI gene (see all 98 ):

High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. (PubMed id 17044054)^{1, 3, 4} Taskinen J.P.... Wierenga R.K. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{3, 4} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
The characterization of two diazepam binding inhibitor (DBI) transcripts in humans. (PubMed id 7534063)^{3, 4} Kolmer M.... Alho H. (1995)
New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and the diazepam binding inhibitor gene. (PubMed id 1440058)^{2, 3} Todd S. and Naylor S.L. (1992)
Bovine and human cDNA sequences encoding a putative benzodiazepine receptor ligand. (PubMed id 2881742)^{3, 4} Webb N.R....Lee D.C. (1987)
Cloning and expression of cDNA for human diazepam binding inhibitor, a natural ligand of an allosteric regulatory site of the gamma- aminobutyric acid type A receptor. (PubMed id 3020548)^{3, 4} Gray P.W.... Costa E. (1986)
Complete amino acid sequences of bovine and human endozepines. Homology with rat diazepam binding inhibitor. (PubMed id 3525533)^{3, 4} Marquardt H.... Shoyab M. (1986)
The transcriptional and translational control of diazepam binding inhibitor expression in rat male germ-line cells. (PubMed id 9022045)^{1, 3} Kolmer M....Alho H. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1622	HGNC: 2690	AceView: DBI	Ensembl:ENSG00000155368	euGenes: HUgn1622
ECgene: DBI	H-InvDB: DBI

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DBI	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DBI
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DBI:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DBI-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DBI		Antibodies for DBI
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DBI		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (DBI)
	Antibodies (DBI)
	Chimera RNAi (DBI)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (Diazepam Binding Inhibitor)
	Antibodies (Diazepam Binding Inhibitor)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for DBI

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for DBI

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
DBI Gene at Home site.
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DBI Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for DBI

Summaries
for DBI

Genomic Location
for DBI

Proteins
for DBI

Protein Domains/
Families
for DBI

Gene Function
for DBI

Pathways & Interactions
for DBI

Drugs & Compounds
for DBI

Transcripts
for DBI

Expression
for DBI

Orthologs
for DBI

Paralogs
for DBI

SNPs/Variants
for DBI

Disorders & Mutations
for DBI

Medical News
for DBI

Publications
for DBI

Search for DBI

Genome Databases showing DBI

Other Databases showing DBI

Specialized Databases showing DBI

Licensable Technologies
for DBI

Services
for DBI

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DBI Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor DBI

Summariesfor DBI

Genomic Locationfor DBI

Proteinsfor DBI

Protein Domains/Familiesfor DBI

Gene Functionfor DBI

Pathways & Interactionsfor DBI

Drugs & Compoundsfor DBI

Transcriptsfor DBI

Expression for DBI

Orthologsfor DBI

Paralogsfor DBI

SNPs/Variantsfor DBI

Disorders & Mutationsfor DBI

Medical Newsfor DBI

Publicationsfor DBI

Search for DBI

Genome Databases showing DBI

Other Databases showing DBI

Specialized Databases showing DBI

Licensable Technologiesfor DBI

Servicesfor DBI

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DBI

Summaries
for DBI

Genomic Location
for DBI

Proteins
for DBI

Protein Domains/
Families
for DBI

Gene Function
for DBI

Pathways & Interactions
for DBI

Drugs & Compounds
for DBI

Transcripts
for DBI

Expression
for DBI

Orthologs
for DBI

Paralogs
for DBI

SNPs/Variants
for DBI

Disorders & Mutations
for DBI

Medical News
for DBI

Publications
for DBI

Licensable Technologies
for DBI

Services
for DBI