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Aliases for DBI Gene

Aliases for DBI Gene

  • Diazepam Binding Inhibitor, Acyl-CoA Binding Protein 2 3 5
  • Endozepine 2 3 4
  • Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-Coenzyme A Binding Protein) 2 3
  • Diazepam-Binding Inhibitor 3 4
  • ACBP 3 4
  • EP 3 4
  • Diazepam Binding Inhibitor (GABA Receptor Modulator, Acyl-CoA Binding Protein) 3
  • Cholecystokinin-Releasing Peptide, Trypsin-Sensitive 3
  • Acyl-Coenzyme A Binding Domain Containing 1 3
  • Acyl Coenzyme A Binding Protein 3
  • Acyl-CoA-Binding Protein 3
  • GABA Receptor Modulator 3
  • CCK-RP 3
  • ACBD1 3

External Ids for DBI Gene

Previous GeneCards Identifiers for DBI Gene

  • GC02P117330
  • GC02P118045
  • GC02P120031
  • GC02P120219
  • GC02P120220
  • GC02P119840
  • GC02P120124
  • GC02P112449

Summaries for DBI Gene

Entrez Gene Summary for DBI Gene

  • This gene encodes diazepam binding inhibitor, a protein that is regulated by hormones and is involved in lipid metabolism and the displacement of beta-carbolines and benzodiazepines, which modulate signal transduction at type A gamma-aminobutyric acid receptors located in brain synapses. The protein is conserved from yeast to mammals, with the most highly conserved domain consisting of seven contiguous residues that constitute the hydrophobic binding site for medium- and long-chain acyl-Coenzyme A esters. Diazepam binding inhibitor is also known to mediate the feedback regulation of pancreatic secretion and the postprandial release of cholecystokinin, in addition to its role as a mediator in corticotropin-dependent adrenal steroidogenesis. Three pseudogenes located on chromosomes 6, 8 and 16 have been identified. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for DBI Gene

DBI (Diazepam Binding Inhibitor, Acyl-CoA Binding Protein) is a Protein Coding gene. Diseases associated with DBI include Hepatic Coma. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. GO annotations related to this gene include protein dimerization activity and fatty-acyl-CoA binding. An important paralog of this gene is ACBD7.

UniProtKB/Swiss-Prot for DBI Gene

  • Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Gene Wiki entry for DBI Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBI Gene

Genomics for DBI Gene

Regulatory Elements for DBI Gene

Enhancers for DBI Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G119387 1.2 Ensembl ENCODE 20.3 +20.8 20838 1.5 HDAC1 ELF3 RAD21 RARA YY1 ZNF766 EGR1 SCRT2 FOS RELB DBI ENSG00000231013 C2orf76 TMEM37 SCTR STEAP3 PIR46529
GH02G119419 2 FANTOM5 Ensembl ENCODE dbSUPER 7.2 +61.2 61176 16.7 HDGF PKNOX1 FOXA2 MLX ARID4B ZNF2 ZBTB7B YY1 SLC30A9 ZNF143 SCTR ENSG00000231013 CFAP221 TMEM37 DBI STEAP3 PIR46529
GH02G119407 1.3 Ensembl ENCODE dbSUPER 8.4 +41.5 41487 1.6 ZSCAN5A CTCF PKNOX1 TEAD4 ARID4B DNMT3B ZNF2 RAD21 TEAD3 ZNF316 ENSG00000231013 TMEM37 SCTR DBI PIR46529
GH02G119355 0.9 FANTOM5 Ensembl 11.7 -10.8 -10821 0.6 ZNF146 MTA2 CBX5 IKZF1 RELB IKZF2 EP300 DBI C2orf76 LOC105373581
GH02G119401 1.1 ENCODE dbSUPER 9.4 +36.1 36052 2.4 ELF3 RAD21 YY1 THAP11 CEBPB ELF1 NR2F2 KAT8 PPARGC1A ATF4 ENSG00000231013 TMEM37 STEAP3 SCTR DBI PIR46529
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DBI on UCSC Golden Path with GeneCards custom track

Promoters for DBI Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000122364 79 2401 HDGF FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766

Genomic Location for DBI Gene

Chromosome:
2
Start:
119,366,921 bp from pter
End:
119,372,560 bp from pter
Size:
5,640 bases
Orientation:
Plus strand

Genomic View for DBI Gene

Genes around DBI on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBI Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBI Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBI Gene

Proteins for DBI Gene

  • Protein details for DBI Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P07108-ACBP_HUMAN
    Recommended name:
    Acyl-CoA-binding protein
    Protein Accession:
    P07108
    Secondary Accessions:
    • B8ZWD2
    • B8ZWD6
    • B8ZWD7
    • P08869
    • Q4VWZ6
    • Q53SQ7
    • Q6IB48
    • Q9UCI8

    Protein attributes for DBI Gene

    Size:
    87 amino acids
    Molecular mass:
    10044 Da
    Quaternary structure:
    • Monomer.

    Three dimensional structures from OCA and Proteopedia for DBI Gene

    Alternative splice isoforms for DBI Gene

neXtProt entry for DBI Gene

Post-translational modifications for DBI Gene

  • Ubiquitination at isoforms=2, 3, 4, 555 and Lys77
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DBI Gene

Domains & Families for DBI Gene

Graphical View of Domain Structure for InterPro Entry

P07108

UniProtKB/Swiss-Prot:

ACBP_HUMAN :
  • Belongs to the ACBP family.
Family:
  • Belongs to the ACBP family.
genes like me logo Genes that share domains with DBI: view

No data available for Gene Families for DBI Gene

Function for DBI Gene

Molecular function for DBI Gene

GENATLAS Biochemistry:
diazepam binding inhibitor (?GABA receptor modulator),endozepine
UniProtKB/Swiss-Prot Function:
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor.

Gene Ontology (GO) - Molecular Function for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008289 lipid binding IEA --
GO:0030156 benzodiazepine receptor binding TAS 3020548
GO:0036042 long-chain fatty acyl-CoA binding IDA 21079819
GO:0046983 protein dimerization activity IDA 21079819
genes like me logo Genes that share ontologies with DBI: view
genes like me logo Genes that share phenotypes with DBI: view

Animal Models for DBI Gene

MGI Knock Outs for DBI:

Animal Model Products

  • Taconic Biosciences Mouse Models for DBI

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for DBI

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DBI Gene

Localization for DBI Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBI Gene

Endoplasmic reticulum. Golgi apparatus. Note=Golgi localization is dependent on ligand binding (PubMed:17953517). {ECO:0000269 PubMed:17953517}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBI gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 5
golgi apparatus 5
cytosol 4
nucleus 3
mitochondrion 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005788 endoplasmic reticulum lumen TAS --
GO:0005794 Golgi apparatus IEA --
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DBI: view

Pathways & Interactions for DBI Gene

genes like me logo Genes that share pathways with DBI: view

SIGNOR curated interactions for DBI Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DBI Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006637 acyl-CoA metabolic process TAS --
GO:0006810 transport IEA --
GO:0018345 NOT protein palmitoylation IDA 21079819
GO:0035338 long-chain fatty-acyl-CoA biosynthetic process TAS --
GO:0036151 phosphatidylcholine acyl-chain remodeling IDA 21079819
genes like me logo Genes that share ontologies with DBI: view

Drugs & Compounds for DBI Gene

(5) Drugs for DBI Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Hexadecanal Experimental Pharma Target 0
Propionyl-CoA Experimental Pharma 0
Coenzyme A Nutra Target 0

(38) Additional Compounds for DBI Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with DBI: view

Transcripts for DBI Gene

Unigene Clusters for DBI Gene

Diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein):
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for DBI

Alternative Splicing Database (ASD) splice patterns (SP) for DBI Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - - - -
SP6: -
SP7: - - - - -
SP8: - -

Relevant External Links for DBI Gene

GeneLoc Exon Structure for
DBI
ECgene alternative splicing isoforms for
DBI

Expression for DBI Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBI Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DBI Gene

This gene is overexpressed in Oral epithelium (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DBI Gene



Protein tissue co-expression partners for DBI Gene

NURSA nuclear receptor signaling pathways regulating expression of DBI Gene:

DBI

SOURCE GeneReport for Unigene cluster for DBI Gene:

Hs.78888

mRNA Expression by UniProt/SwissProt for DBI Gene:

P07108-ACBP_HUMAN
Tissue specificity: Isoform 1 is ubiquitous, with a moderate expression level. Isoform 2 is ubiquitous with high level in liver and adipose tissue. Isoform 3 is ubiquitous with strong expression in adipose tissue and heart.

Evidence on tissue expression from TISSUES for DBI Gene

  • Liver(4.9)
  • Nervous system(4.8)
  • Blood(4.3)
  • Kidney(3.3)
  • Intestine(3.1)
  • Heart(2.8)
  • Muscle(2.7)
  • Adrenal gland(2.6)
  • Lung(2.5)
  • Skin(2.5)
  • Spleen(2.5)
  • Gall bladder(2)
  • Lymph node(2)
  • Pancreas(2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with DBI: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBI Gene

Orthologs for DBI Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DBI Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBI 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia DBI 34 35
  • 91.57 (n)
mouse
(Mus musculus)
Mammalia Dbi 34 16 35
  • 82.38 (n)
rat
(Rattus norvegicus)
Mammalia Dbi 34
  • 82.38 (n)
oppossum
(Monodelphis domestica)
Mammalia DBI 35
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBI 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBI 34 35
  • 74.71 (n)
lizard
(Anolis carolinensis)
Reptilia DBI 35
  • 80 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75740 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.2125 34
zebrafish
(Danio rerio)
Actinopterygii dbi 34 35
  • 73.95 (n)
zgc77734 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3079 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP007460 34
  • 63.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta Dbi 34 35
  • 57.36 (n)
CG8498 35
  • 52 (a)
ManyToMany
CG8628 35
  • 46 (a)
ManyToMany
CG8629 35
  • 46 (a)
ManyToMany
CG5804 35
  • 43 (a)
ManyToMany
CG15829 35
  • 40 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea acbp-1 34 35
  • 63.41 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL188W 34
  • 57.61 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ACB1 34 35 37
  • 57.61 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0B05643g 34
  • 56.59 (n)
wheat
(Triticum aestivum)
Liliopsida Ta.1334 34
corn
(Zea mays)
Liliopsida Zm.7156 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1539.06 34
  • 57.32 (n)
Species where no ortholog for DBI was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DBI Gene

ENSEMBL:
Gene Tree for DBI (if available)
TreeFam:
Gene Tree for DBI (if available)

Paralogs for DBI Gene

Paralogs for DBI Gene

(7) SIMAP similar genes for DBI Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DBI: view

Variants for DBI Gene

Sequence variations from dbSNP and Humsavar for DBI Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000068537 -- 119,368,613(+) TATCA(C/T)TGTTG intron-variant, upstream-variant-2KB
rs1000201298 -- 119,366,117(+) CTAAG(A/C)CCCTA intron-variant, upstream-variant-2KB
rs1000445755 -- 119,371,678(+) TCCTT(C/T)CTACT intron-variant
rs1000662734 -- 119,369,959(+) GAGAG(A/G)GCTGT intron-variant
rs1000733822 -- 119,371,420(+) CCTCT(C/G)TCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBI Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV gain 19166990
nsv508862 CNV insertion 20534489
nsv582784 CNV gain 21841781

Variation tolerance for DBI Gene

Residual Variation Intolerance Score: 63.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.49; 77.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBI Gene

Human Gene Mutation Database (HGMD)
DBI
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBI

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBI Gene

Disorders for DBI Gene

MalaCards: The human disease database

(1) MalaCards diseases for DBI Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatic coma
  • hepatocerebral intoxication
- elite association - COSMIC cancer census association via MalaCards
Search DBI in MalaCards View complete list of genes associated with diseases

Relevant External Links for DBI

Genetic Association Database (GAD)
DBI
Human Genome Epidemiology (HuGE) Navigator
DBI
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBI
genes like me logo Genes that share disorders with DBI: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DBI Gene

Publications for DBI Gene

  1. High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand. (PMID: 17044054) Taskinen J.P. … Wierenga R.K. (Proteins 2007) 3 4 22 64
  2. Association of acyl-CoA-binding protein (ACBP) single nucleotide polymorphisms and type 2 diabetes in two German study populations. (PMID: 17262885) Fisher E. … DAPring F. (Mol Nutr Food Res 2007) 3 22 46 64
  3. Identification of new acyl-CoA binding protein transcripts in human and mouse. (PMID: 16055366) Nitz I. … Burwinkel B. (Int. J. Biochem. Cell Biol. 2005) 3 4 22 64
  4. Identification of a novel human Acyl-CoA binding protein isoform with a unique C-terminal domain. (PMID: 21698759) Ludewig A.H. … Doring F. (IUBMB Life 2011) 3 4 64
  5. Specific regulation of low-abundance transcript variants encoding human Acyl-CoA binding protein (ACBP) isoforms. (PMID: 20345851) Nitz I. … Doring F. (J. Cell. Mol. Med. 2011) 3 4 64

Products for DBI Gene

Sources for DBI Gene

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