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DBH Gene

protein-coding GIFtS: 68

GC09P135491

dopamine beta-hydroxylase (dopamine beta-monooxygenase)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DBM ^¹, ²
EC 1.14.17.1 ^³

Descriptions
Dopamine beta-monooxygenase ^³
dopamine beta hydroxylase ^²
dopamine beta-hydroxylase (dopamine beta-monooxygenase) ^²

External Ids
HGNC: 2689¹
Entrez Gene: 1621²
UniProtKB: P09172³
Ensembl: ENSG00000123454⁷

Search outside databases for aliases for DBH gene

Previous GC identifers: GC09P127576 GC09P128007 GC09P129926 GC09P131843 GC09P133531

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DBH:

The protein encoded by this gene is an oxidoreductase belonging to the copper type II,

ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic

sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and

membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.

[provided by RefSeq]

UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172

Function: Conversion of dopamine to noradrenaline

Gene Wiki entry for DBH (Dopamine_beta_hydroxylase)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DBH gene

Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34

DBH Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P135491: (about GC identifiers)

Start:	135,491,306 bp from pter
End:	135,514,287 bp from pter
Size:	22,982 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_035014.4

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172 (See protein sequence)

Recommended Name: Dopamine beta-hydroxylase

Size: 617 amino acids; 69065 Da

Cofactor: Binds 1 PQQ per subunit

Cofactor: Binds 2 copper ions per subunit

Subunit: Homotetramer composed of two non-covalently bound disulfide-linked dimers

Subcellular location: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle

lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen

Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane

protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II

membrane protein (Potential)

Secondary accessions: Q5T381 Q96AG2

REFSEQ proteins: NP_000778.3

ENSEMBL proteins:

ENSP00000376776 ENSP00000263611 ENSP00000360947

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (Dopamine beta Hydroxylase)
	Human Recombinant Proteins from Abnova (DBH)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/8 Gene Ontology (GO) cellular component terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	NAS	14718574
GO:0005624	membrane fraction	TAS	3443096
GO:0005625	soluble fraction	TAS	3443096
GO:0005737	cytoplasm	TAS	3443096
GO:0016020	membrane	IEA	--

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Antibodies for DBH:

	Invitrogen Antibodies for DBH
	Millipore Mono- and Polyclonal Antibodies for the study of DBH
	Sigma-Aldrich Antibodies for DBH
	R&D Systems Antibodies for DBH (Dopamine beta-Hydroxylase)
	Antibodies from Abcam (Dopamine beta Hydroxylase), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DBH)
	Novus Biologicals Antibodies for DBH

Assays for DBH:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P09172

ProtoNet protein and cluster: P09172

3 Blocks protein families:

IPB000323 Copper type II

IPB000945 Dopamine-beta-monooxygenase signature

IPB005018 DOMON domain

UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172

Similarity: Belongs to the copper type II ascorbate-dependent monooxygenase family

Similarity: Contains 1 DOMON domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DBH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DBH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000787

Applied Biosystems Silencer® siRNAs for DBH

Sigma-Aldrich siRNA and siRNA Panels for DBH

Sigma-Aldrich shRNA for DBH

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000787
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000787
untagged cDNA clones in CMV expression vector (see all 3): NM_000787

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000787

UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172

Function: Conversion of dopamine to noradrenaline

Catalytic activity: 3,4-dihydroxyphenethylamine + ascorbate + O(2) = noradrenaline +

dehydroascorbate + H(2)O

Induction: Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal

medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids

Enzyme Number (IUBMB): EC 1.14.17.1

Genatlas biochemistry entry for DBH:

dopamine beta-hydroxylase,copper dependent (dopamine beta-monooxygenase),catecholamine

production,induced by cAMP through AP1 proteins,FOS and JUN with a polymorphism (nt 910) not

associated with susceptibility to schizophrenia

12 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dbh):

	behavior/neurological	digestive/alimentary	endocrine/exocrine gland	growth/size
homeostasis/metabolism	lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	nervous system
touch/vibrissae	vision/eye

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004497	monooxygenase activity	IEA	--
GO:0004500	dopamine beta-monooxygenase activity	IEA	--
GO:0005507	copper ion binding	IEA	--
GO:0031418	L-ascorbic acid binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for DBH (Your Favorite Gene powered by Ingenuity)

Tyrosine Metabolism

GeneDecks DBH for the pathways selected above

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UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172

Pathway: Catecholamine biosynthesis; norepinephrine biosynthesis; norepinephrine from dopamine:

step 1/1

Gene Network Central^TM Interacting Genes and Proteins Network for DBH

5/51 Interacting proteins for DBH (ENSP00000263611³ P09172²) via UniProtKB, MINT, and/or STRING (see all 51 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITSN1	Q15811²	MINT-2843945
COMT	ENSP00000207636³	STRING (score=.983)
PNMT	ENSP00000269582³	STRING (score=.981)
DDC	ENSP00000339928³	STRING (score=.975)
SLC18A2	ENSP00000298472³	STRING (score=.967)

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5 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006548	histidine catabolic process	IEA	--
GO:0007268	synaptic transmission	TAS	2880016
GO:0009987	cellular process	IEA	--
GO:0042423	catecholamine biosynthetic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for DBH:

Inhibitor

Browse Tocris compounds for DBH
10/56 Novoseek chemical compound relationships for DBH gene (see all 56 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
1,3-dibromo-5,5-dimethylhydantoin	88.65	52	11929677 (5), 11933844 (4), 11929673 (3), 11683121 (3) (see all 10)
peptidylglycine	84.79	23	16344970 (2), 7540562 (1), 18399242 (1), 16504568 (1) (see all 21)
catecholamine	79.73	91	8789282 (3), 7961964 (3), 8434878 (2), 17131588 (2) (see all 48)
nepicastat	78.65	5	9283721 (4), 10197057 (1)
tyrosine	73.01	219	8910734 (4), 8789282 (4), 8783042 (3), 7777160 (3) (see all 99)
dops	67.99	2	17017570 (1), 1449487 (1)
l-amino acid	65.07	17	9532591 (1), 1684618 (1), 1353277 (1), 8436980 (1) (see all 12)
vanillylmandelic acid	63.25	7	7842240 (2), 15702409 (1), 16952582 (1), 1950338 (1) (see all 5)
dmpd	61.02	5	1785690 (4)
copper	54.36	51	9839952 (3), 19178946 (3), 7546340 (2), 7864832 (2) (see all 34)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DBH)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DBH)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000787

Sigma-Aldrich siRNA and siRNA Panels for DBH

Sigma-Aldrich shRNA for DBH

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000787

REFSEQ mRNAs for DBH gene:

NM_000787.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000787

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000787
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000787
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_000787

Additional cDNA sequence:

BC017174.2 CR596213.1 X13255.1 X13256.1 Y00096.1

11 DOTS entries:

DT.208811 DT.92429503 DT.92429501 DT.97835491 DT.100652745 DT.99968007 DT.100638282 DT.100738899

DT.100738900 DT.100769572 DT.97822508

24/3637 AceView cDNA sequences (see all 3637 ):

AA384240 BM554601 BE251943 BU931937 BG338966 BI261608 BQ925047 BM747072

CB105166 BU856394 CD370170 BU541995 BQ942874 BM557936 BQ061426 CB121193

BM739325 BE297116 CD366491 BE796389 BG820885 BQ876535 CA422504 BG288914

highest scoring ESTs for DBH:

X13255 AL515786 AL517920 AL526131 AW872875 BC017174 BE260752 BF206759 BF311996 BF314790

Unigene Cluster for DBH:

Dopamine beta-hydroxylase (dopamine beta-monooxygenase)

Hs.591890 [show with all ESTs]

Unigene Representative Sequence: NM_000787

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000393056 ENST00000263611 ENST00000371880

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DBH expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DBH

¹ / ² / ³

3 probe-sets matching DBH gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
32943_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X13255	1.00	1.00	1.00	1
206450_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000787	0.60	1.00	0.82	1
206450_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DBH for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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CGAP SAGE TAG: CTGGGCCGGG

SOURCE GeneReport for Unigene cluster: Hs.591890
Expression variation in blood from EXPOLDB for DBH

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for DBH gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DBH¹	--	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	81.57(n) 76.07(a)	448806 XM_850508.1 XP_855601.1
chimpanzee (Pan troglodytes)	DBH¹	--	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	99.14(n) 99.19(a)	464827 XM_520341.2 XP_520341.2
cow (Bos taurus)	DBH¹	--	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	85.58(n) 84.7(a)	280758 NM_180995.2 NP_851338.1
rat (Rattus norvegicus)	Dbh¹	--	dopamine beta-hydroxylase (dopamine beta-monooxygenase)	78.67(n) 77.8(a)	25699 NM_013158.1 NP_037290.1
mouse (Mus musculus)	Dbh^{1, 5}	2 (15.50 cM)⁵	dopamine beta hydroxylase^{1, 5}	80.38(n)¹ 80.93(a)¹	13166¹ NM_138942.3¹ NP_620392.2¹ AK132245⁵ AL954801⁵ (see all 9)

About this table Species with no ortholog for DBH

ENSEMBL Gene Tree for DBH

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for DBH gene

MOXD2² MOXD1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172

Polymorphism: There are two main alleles of DBH: DBH-A with Ala-318 and DBH-B with Ser-318

10/307 NCBI SNPs in DBH are shown (see all 307 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 201)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1611114^1,2	A,C,F,H,O	135490024(+)	`ACGTTT/CGTGCA`	1	--	ng5¹		7	EA NA WA	514
	rs1611115^1,2	A,C,F,H	135490336(+)	`ACTTGC/TGGGAG`	1	--	ng5¹		10	NA EU EA WA	1238
	rs5324^1,2	C,F,H,O	135498479(+)	`AACCCG/AACCGC`	1	N/D	mis¹ ese³		9	MN NA EU EA WA	824
	rs6271^1,2	C,F,H,O	135512095(+)	`TCAACC/TGCGAC`	1	R/C	mis¹ ese³		17	MN NA EU EA WA	1654
	rs129915^1,2	A,C,F,H	135514739(+)	`GAGCCA/GCTCCG`	1	--	ng3¹		7	EA EU WA	2106
	rs129882^1,2	A,C,F,H	135513490(+)	`CTGCAC/TGCCCA`	1	--	ut3¹ ese³		13	MN EA NA EU WA	1236
	rs129883^1,2	A,C,F,H	135514632(+)	`GGGAAC/GTCACG`	1	--	ng3¹		8	EU EA WA	834
	rs5320^1,2	C,F,H	135497294(+)	`CAGACG/ACGTGC`	1	T/A	mis¹ ese³		11	MN EU EA WA NA	1244
	rs5321^1,2	C,F,H	135497380(+)	`CCAAAG/CGGCTT`	1	N/K	mis¹ ese³		10	MN EU EA WA	1064
	rs3025431^1,2	F,H	135514424(+)	`CCCCTT/GCCTGC`	1	--	ng3¹		4	EU EA WA	372

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HapMap Linkage Disequilibrium images for DBH (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 609312

UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172

Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine

deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in

autonomic and cardiovascular function, but apparently only subtle signs, if any, of central

nervous system dysfunction

10/72 Novoseek disease relationships for DBH gene (see all 72 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pure autonomic failure	77.32	9	17017570 (1), 9773098 (1), 16966943 (1), 9886450 (1) (see all 8)
hypotension orthostatic	66.77	7	17017570 (1), 8529034 (1), 15495941 (1), 17214596 (1) (see all 7)
menkes disease	65.65	3	15702409 (1), 12594858 (1), 8434878 (1)
attention-deficit hyperactivity disorder	64.50	11	16876143 (2), 15088079 (1), 17187001 (1), 10334470 (1) (see all 9)
dystonia hereditary	60.02	1	1677923 (1)
dysautonomia familial	58.91	3	16966943 (1), 9886450 (1)
occipital horn syndrome	56.62	1	12594858 (1)
autonomic disorder	54.44	8	12833405 (2), 2300263 (1), 12438171 (1)
torsion dystonia	53.62	7	2215959 (2), 1677923 (1), 11571351 (1)
multiple system atrophy	50.59	4	17017570 (1), 9773098 (1), 9886450 (1), 18368300 (1)

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GeneTests: DBH

Dopamine Beta-Hydroxylase Deficiency

Human Gene Mutation Database: DBH
Genetic Association Database: DBH
Human Genome Epidemiology Navigator: DBH (64 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/542 PubMed articles for DBH gene (see all 542 ):

No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH). (PubMed id 10490716)^{1, 3, 4, 6} Williams H.J....Owen M.J. (1999)
Expression of human dopamine beta-hydroxylase in Drosophila Schneider 2 cells. (PubMed id 8546710)^{1, 3, 4} Li B....Barnett J. (1996)
Association of dopamine beta-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese. (PubMed id 16097364)^{1, 3, 6} Abe M....Nakura J. (2005)
Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study. (PubMed id 12555232)^{1, 3, 6} Yamamoto K....Joober R. (2003)
Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression. (PubMed id 11904129)^{1, 3, 6} Cubells J.F....Gelernter J. (2002)
Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency. (PubMed id 11857564)^{1, 3, 4} Kim C.-H.... Kim K.-S. (2002)
Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch. (PubMed id 15077009)^{1, 3, 6} Johnstone E.C....Walton R.T. (2004)
Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy. (PubMed id 12833405)^{1, 3, 6} Cho S....Kim K.S. (2003)
No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia. (PubMed id 12960750)^{1, 3, 6} Jonsson E.G....Sedvall G.C. (2003)
Polymorphisms in the DBH and DRD2 gene regions and smoking behavior. (PubMed id 16032443)^{1, 3, 6} Freire M.T....Bau C.H. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1621	HGNC: 2689	AceView: DBHandRPL7AandSURF2	Ensembl:ENSG00000123454	euGenes: HUgn1621
ECgene: DBH	H-InvDB: DBH

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
GeneReviews	http://www.genetests.org/query?gene=DBH
Wikipedia	http://en.wikipedia.org/wiki/Dopamine_beta_hydroxylase

Licensable Technologies for DBH
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DBH:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DBH-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DBH		Antibodies for DBH
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DBH		Small molecules for DBH
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Recombinant Proteins (Dopamine beta Hydroxylase)
	Antibodies (Dopamine beta Hydroxylase)

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Antibodies for DBH

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
DBH Gene at Home site.
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DBH Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for DBH

Summaries
for DBH

Genomic Location
for DBH

Proteins
for DBH

Protein Domains/
Families
for DBH

Gene Function
for DBH

Pathways & Interactions
for DBH

Drugs & Compounds
for DBH

Transcripts
for DBH

Expression
for DBH

Orthologs
for DBH

Paralogs
for DBH

SNPs/Variants
for DBH

Disorders & Mutations
for DBH

Medical News
for DBH

Publications
for DBH

Search for DBH

Genome Databases showing DBH

Other Databases showing DBH

Specialized Databases showing DBH

Licensable Technologies
for DBH

Services
for DBH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DBH Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor DBH

Summariesfor DBH

Genomic Locationfor DBH

Proteinsfor DBH

Protein Domains/Familiesfor DBH

Gene Functionfor DBH

Pathways & Interactionsfor DBH

Drugs & Compoundsfor DBH

Transcriptsfor DBH

Expression for DBH

Orthologsfor DBH

Paralogsfor DBH

SNPs/Variantsfor DBH

Disorders & Mutationsfor DBH

Medical Newsfor DBH

Publicationsfor DBH

Search for DBH

Genome Databases showing DBH

Other Databases showing DBH

Specialized Databases showing DBH

Licensable Technologiesfor DBH

Servicesfor DBH

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DBH

Summaries
for DBH

Genomic Location
for DBH

Proteins
for DBH

Protein Domains/
Families
for DBH

Gene Function
for DBH

Pathways & Interactions
for DBH

Drugs & Compounds
for DBH

Transcripts
for DBH

Expression
for DBH

Orthologs
for DBH

Paralogs
for DBH

SNPs/Variants
for DBH

Disorders & Mutations
for DBH

Medical News
for DBH

Publications
for DBH

Licensable Technologies
for DBH

Services
for DBH