DBH Gene
protein-coding GIFtS: 68
GCID: GC09P136501
|
|
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
| |
Aliases
for DBH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Dopamine Beta-Hydroxylase (Dopamine Beta-Monooxygenase)1 2 | | DBM1 2 | | EC 1.14.17.13 8 | | Dopamine Beta-Hydroxylase2 | | Dopamine Beta-Monooxygenase3 |
Export aliases for DBH gene to outside databasesPrevious GC identifers: GC09P127576 GC09P128007 GC09P129926 GC09P131843 GC09P133531 GC09P135491 GC09P106002 |
Summaries
for DBH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DBH:
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependentmonooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and convertsdopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence,respectively, of a signal peptide. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172Function: Conversion of dopamine to noradrenaline
Gene Wiki entry for DBH (Dopamine beta hydroxylase)
|
Genomic Views
for DBH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000009.11 NC_018920.1 NT_035014.4
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DBH gene promoter:
AML1a AP-2alpha isoform 3 AP-2alpha isoform 2 Tal-1beta STAT3 AP-2alpha isoform 4 AP-2alpha ITF-2 AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for DBH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DBH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q34 Ensembl cytogenetic band: 9q34.2 HGNC cytogenetic band: 9q34DBH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P136501: view genomic region
(about GC identifiers)
Start:
|
136,501,482 bp from pter |
End:
|
136,524,466 bp from pter |
Size:
|
22,985 bases |
Orientation:
|
plus strand |
|
Proteins
for DBH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172 (See
protein sequence)Recommended Name: Dopamine beta-hydroxylase Size: 617 amino acids; 69065 Da
Cofactor: Binds 1 PQQ per subunit
Cofactor: Binds 2 copper ions per subunit
Subunit: Homotetramer composed of two non-covalently bound disulfide-linked dimers
Subcellular location: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmicvesicle, secretory vesicle, chromaffin granule lumen
Subcellular location: Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein.Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein (Potential)
Sequence caution: Sequence=AAH17174.1; Type=Erroneous initiation; Sequence=CAA31631.1; Type=Erroneous initiation;Sequence=CAA31632.1; Type=Erroneous initiation; Sequence=CAA68285.1; Type=Erroneous initiation;
Secondary accessions: Q5T381 Q96AG2Explore the universe of human proteins at neXtProt for DBH: NX_P09172
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P09172
4/16 DME Specific Peptides for DBH (P09172) (see all 16)
DBH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_000778.3
ENSEMBL proteins: ENSP00000376776 ENSP00000263611 Reactome Protein details: P09172
Human Recombinant Protein Products:
Gene Ontology (GO): 5/19 cellular component terms (GO ID links to tree view) (see all 19): About this table
DBH for ontologies About GeneDecksing
DBH Antibody Products:
Assay Products for DBH: |
Protein
Domains /
Families
for DBH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DBH for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P09172ProtoNet protein and cluster: P09172 3 Blocks protein families: IPB000323 Copper type II IPB000945 Dopamine-beta-monooxygenase signature IPB005018 DOMON domain
UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172Similarity: Belongs to the copper type II ascorbate-dependent monooxygenase familySimilarity: Contains 1 DOMON domain |
Function
for DBH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172Function: Conversion of dopamine to noradrenalineCatalytic activity: 3,4-dihydroxyphenethylamine + ascorbate + O(2) = noradrenaline + dehydroascorbate + H(2)OInduction: Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla).Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids Genatlas biochemistry entry for DBH:dopamine beta-hydroxylase,copper dependent (dopamine beta-monooxygenase),catecholamine production,induced by cAMPthrough AP1 proteins,FOS and JUN with a polymorphism (nt 910) not associated with susceptibility to schizophrenia
Enzyme Number (IUBMB): EC 1.14.17.11 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DBH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DBH (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: DBH (NM_000787) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DBH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBH |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
DBH for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Dbhtm1Rpa for DBH
9 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Dbh):
DBH for phenotypes About GeneDecksing
|
Pathways & Interactions
for DBH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Tyrosine metabolism | | | 2 | Metabolism | | | 3 | Regulation of thyroid hormone activity | | | 4 | Neuroscience | | | 5 | Metabolism of amino acids and derivatives | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for DBH
1 
Cell Signaling Technology (CST) Pathway for DBH
1  GeneGo (Thomson Reuters) Pathway for DBH
2  BioSystems Pathways for DBH
4 
Reactome Pathways for DBH
1  PharmGKB Pathway for DBH
2 
Kegg Pathways (Kegg details for DBH):
UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172Pathway: Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1
DBH for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DBH
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for DBH (P091722, 3 ENSP000003767764) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
About this table
Gene Ontology (GO): 5/40 biological process terms (GO ID links to tree view) (see all 40): About this table
DBH for ontologies About GeneDecksing
|
Drugs & Compounds
for DBH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DBH for compounds About GeneDecksing
 |
Enzo Life Sciences drugs & compounds for DBH |
 Browse Tocris compounds for DBH
7 HMDB Compounds for DBH About this table
4 DrugBank Compounds for DBH About this table
10/106 Novoseek chemical compound relationships for DBH gene (see all 106) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| dopamine |
89.9 |
1092 |
8143425 (11), 2344453 (6), 1785690 (6), 1688549 (5) (see all 99) |
| 1,3-dibromo-5,5-dimethylhydantoin |
88.6 |
52 |
11929677 (5), 11933844 (4), 11929673 (3), 11683121 (3) (see all 10) |
| peptidylglycine |
84.9 |
24 |
16344970 (2), 7540562 (1), 18399242 (1), 16504568 (1) (see all 22) |
| norepinephrine |
82.2 |
310 |
8369609 (3), 17484728 (3), 20193660 (3), 17625104 (3) (see all 99) |
| catecholamine |
79.3 |
94 |
8789282 (3), 7961964 (3), 8434878 (2), 16614076 (2) (see all 49) |
| nepicastat |
78.3 |
5 |
9283721 (4), 10197057 (1) |
| dl-threo-dihydroxyphenylserine |
73.2 |
1 |
1811317 (1) |
| tyrosine |
72.6 |
224 |
8910734 (4), 8789282 (4), 8783042 (3), 7777160 (3) (see all 99) |
| fusaric acid |
68.2 |
7 |
12417657 (1), 8546710 (1), 10224312 (1), 9220358 (1) |
| dops |
67 |
2 |
17017570 (1), 1449487 (1) |
Search CenterWatch for drugs/clinical trials and news about DBH / DOPO
|
Transcripts
for DBH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DBH gene: NM_000787.3 Unigene Cluster for DBH: Dopamine beta-hydroxylase (dopamine beta-monooxygenase) Hs.591890 [show with all ESTs]Unigene Representative Sequence: NM_0007872 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393056(uc004cel.3) ENST00000263611
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DBH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DBH (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DBH (NM_000787) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DBH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBH |
Additional cDNA sequence: BC017174.2 X13255.1 X13256.1 Y00096.1 11 DOTS entries: DT.208811 DT.92429503 DT.92429501 DT.97835491 DT.100652745 DT.99968007 DT.100638282 DT.100738899 DT.100738900 DT.100769572 DT.97822508 24/3637 AceView cDNA sequences (see all 3637): CA423899 BU539563 AA315319 BU859807 CD107737 BQ073255 AW007719 BQ939949 BE206469 AU099663 BQ681719 BM553121 BM818163 BI856982 AI869994 BM914887 BU164135 BQ947931 BM740968 BG759561 BQ681493 CD364580 BM911178 BM694327
GeneLoc Exon Structure
|
Expression
for DBH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DBH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGGCCGGG
About this image
See DBH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DBH
SOURCE GeneReport for Unigene cluster: Hs.591890
SABiosciences Expression via Pathway-Focused PCR Array including DBH:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DBH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DBH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DBH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DBH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBH |
Orthologs
for DBH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DBH gene from 6/21 species (see all 21) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Dbh1 , 5 |
dopamine beta hydroxylase1, 5 |
80.38(n)1
80.93(a)1 |
|
2 (19.29 cM)5
131661 NM_138942.31 NP_620392.21
271652335 |
chicken
(Gallus gallus) |
Aves |
DBH1 |
dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
73.57(n)
70.12(a) |
|
395549 XM_415429.3 XP_415429.3 |
lizard
(Anolis carolinensis) |
Reptilia |
DBH6 |
-- |
60(a) |
1 ↔ 1 |
GL344411.1(5901-31130) |
zebrafish
(Danio rerio) |
Actinopterygii |
dbh2 |
dopamine beta hydroxylase |
76.25(n) |
|
30505 AF075385.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
Tbh1 , 3 |
dopamine-beta-monooxygenase3
Tyramine beta hydroxylase1 |
40(a)3
52.39(n)1
41.91(a)1 |
|
1 7D23
317181 NM_176711.21 NP_788884.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
H13N06.63
tbh-11 |
Copper type II, ascorbate-dependent
monooxygenase3
Protein TBH-11 |
35(a)3
46.08(n)1
37.25(a)1 |
|
X(15535578-15538710)3
1816391 NM_078161.51 NP_510562.21 |
ENSEMBL Gene Tree for DBH (if available)
TreeFam Gene Tree for DBH (if available) |
Paralogs
for DBH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DBH gene
- PAM2 MOXD12
2 SIMAP similar genes for DBH using alignment to 2 protein entries: DOPO_HUMAN (see all proteins):MOXD2P MOXD1
DBH for paralogs About GeneDecksing
|
Genomic Variants
for DBH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172Polymorphism: There are two main alleles of DBH: DBH-A with Ala-318 and DBH-B with Ser-318
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 9 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DBH (136501482 - 136524466 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DBH: --
Human Gene Mutation Database (HGMD): DBH
Locus Specific Mutation Databases (LSDB): DBH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DBH |
|
Disorders
/ Diseases
for DBH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DBH for disorders About GeneDecksing
OMIM gene information: 609312
OMIM disorders: 223360
UniProtKB/Swiss-Prot: DOPO_HUMAN, P09172
Defects in DBH are the cause of dopamine beta-hydroxylase deficiency (DBH deficiency) [MIM:223360]; also knownas norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits inautonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction
20/86  diseases for DBH (see all 86): About MalaCardsdopamine-beta-hydroxylase activity levels, plasma dopamine beta-hydroxylase deficiency gilles de la tourette syndrome occipital horn syndrome
post-traumatic stress disorder mitral valve prolapse dystonia musculorum deformans attention deficit hyperactivity disorder
manic-depressive illness riley-day syndrome pure autonomic failure torsion dystonia
alcohol withdrawal delirium familial mediterranean fever cocaine abuse cocaine dependence
postural hypotension autonomic neuropathy dysautonomia pre-eclampsia
10/74 Novoseek disease relationships for DBH gene (see all 74) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| pure autonomic failure |
76.6 |
9 |
17017570 (1), 9773098 (1), 16966943 (1), 9886450 (1) (see all 8) |
| menkes disease |
66.9 |
5 |
15702409 (1), 12594858 (1), 8434878 (1), 19234788 (1) |
| hypotension orthostatic |
65.8 |
7 |
17017570 (1), 8529034 (1), 15495941 (1), 17214596 (1) (see all 7) |
| attention-deficit hyperactivity disorder |
65.5 |
12 |
16876143 (2), 15088079 (1), 17187001 (1), 10334470 (1) (see all 10) |
| dystonia hereditary |
57.6 |
1 |
1677923 (1) |
| dysautonomia familial |
57.4 |
3 |
16966943 (1), 9886450 (1) |
| occipital horn syndrome |
55.9 |
1 |
12594858 (1) |
| autonomic disorder |
53.4 |
8 |
12833405 (2), 2300263 (1), 12438171 (1) |
| torsion dystonia |
52.5 |
7 |
2215959 (2), 1677923 (1), 11571351 (1) |
| pheochromocytoma |
50 |
26 |
12651811 (3), 1353277 (2), 9578504 (2), 7602797 (2) (see all 13) |
GeneTests: DBH
Dopamine Beta-Hydroxylase Deficiency
Genetic Association Database (GAD): DBH
Human Genome Epidemiology (HuGE) Navigator: DBH (102 documents)
Export disorders for DBH gene to outside databases
|
Publications
for DBH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DBH gene, integrated from 9 sources (see all 676):
(articles sorted by number of sources associating them with DBH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- No evidence for allelic association between schizophrenia and a functional variant of the human dopamine beta-hydroxylase gene (DBH). (PubMed id 10490716)1, 2, 4, 9 Williams H.J....Owen M.J. (1999)
- Dopamine-beta-hydroxylase in postural tachycardia syndrome. (PubMed id 17625104)1, 7, 9 Garland E.M....Robertson D. (2007)
- Expression of human dopamine beta-hydroxylase in Drosophila Schneider 2 cells. (PubMed id 8546710)1, 2, 9 Li B....Barnett J. (1996)
- Association of dopamine beta-hydroxylase polymorphism with hypertension through interaction with fasting plasma glucose in Japanese. (PubMed id 16097364)1, 4, 9 Abe M....Nakura J. (2005)
- Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study. (PubMed id 12555232)1, 4, 9 Yamamoto K....Joober R. (2003)
- Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression. (PubMed id 11904129)1, 4, 9 Cubells J.F....Gelernter J. (2002)
- Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency. (PubMed id 11857564)1, 2, 9 Kim C.-H.... Kim K.-S. (2002)
- Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+ 1603C --> T) with plasma dopamine beta-hydroxylase activity. (PubMed id 16152569)1, 4, 9 Tang Y....Cubells J.F. (2005)
- No association between a putative functional promoter variant in the dopamine beta-hydroxylase gene and schizophrenia. (PubMed id 12960750)1, 4, 9 Jonsson E.G....Sedvall G.C. (2003)
- Polymorphisms in the DBH and DRD2 gene regions and smoking behavior. (PubMed id 16032443)1, 4, 9 Freire M.T....Bau C.H. (2006)
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External Searches for DBH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing DBH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing DBH gene
(According to HUGE)
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Specialized Databases showing DBH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for DBH | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DBH | | Wikipedia | http://en.wikipedia.org/wiki/Dopamine_beta_hydroxylase |
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About This Section
| Patent Information for DBH gene:
Search GeneIP for patents involving DBH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for DBH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | OriGene Antibodies for DBH | | OriGene shRNA RFP for DBH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DBH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DBH | | | OriGene Protein Over-expression Lysate for DBH | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DBH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DBH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DBH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DBH | | OriGene Custom Protein Services for DBH | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DBH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DBH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DBH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DBH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DBH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DBH |
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| | Antibodies & Assays for DBH |
| | | | Search Tocris compounds for DBH |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBH |
|  |  |  | | | | ThermoFisher Antibody for DBH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DBH |
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